GenomeNet

Database: Pfam
Entry: K_channel_TID
LinkDB: K_channel_TID
Original site: K_channel_TID 
#=GF ID   K_channel_TID
#=GF AC   PF07941.12
#=GF DE   Potassium channel Kv1.4 tandem inactivation domain
#=GF AU   Fenech M;0000-0001-7933-4617
#=GF SE   Pfam-B_7603 (release 14.0)
#=GF GA   25.00 25.00;
#=GF TC   25.30 29.20;
#=GF NC   24.90 24.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   KCNA4
#=GF RN   [1]
#=GF RM   12590144
#=GF RT   Solution structure and function of the "tandem inactivation
#=GF RT   domain" of the neuronal A-type potassium channel Kv1.4. 
#=GF RA   Wissmann R, Bildl W, Oliver D, Beyermann M, Kalbitzer HR,
#=GF RA   Bentrop D, Fakler B; 
#=GF RL   J Biol Chem 2003;278:16142-16150.
#=GF DR   INTERPRO; IPR012897;
#=GF DR   SCOP; 1kn7; sf;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family features the tandem inactivation domain found at the
#=GF CC   N-terminus of the Kv1.4 potassium channel. It is composed of two
#=GF CC   subdomains. Inactivation domain 1 (ID1, residues 1-38) consists
#=GF CC   of a flexible N-terminus anchored at a 5-turn helix, and is
#=GF CC   thought to work by occluding the ion pathway, as is the case
#=GF CC   with a classical ball domain. Inactivation domain 2 (ID2,
#=GF CC   residues 40-50) is a 2.5 turn helix with a high proportion of
#=GF CC   hydrophobic residues that probably serves to attach ID1 to the
#=GF CC   cytoplasmic face of the channel. In this way, it can promote
#=GF CC   rapid access of ID1 to the receptor site in the open channel.
#=GF CC   ID1 and ID2 function together to being about fast inactivation
#=GF CC   of the Kv1.4 channel, which is important for the channel's role
#=GF CC   in short-term plasticity [1].
#=GF SQ   98
#=GS A0A452GZY5_9SAUR/1-77    AC A0A452GZY5.1
#=GS Q5REB6_PONAB/1-74        AC Q5REB6.1
#=GS L5KX80_PTEAL/1-94        AC L5KX80.1
#=GS A0A091HNY4_CALAN/1-77    AC A0A091HNY4.1
#=GS A0A3Q1ELJ4_9TELE/1-97    AC A0A3Q1ELJ4.1
#=GS F7IQA3_CALJA/1-74        AC F7IQA3.1
#=GS A0A3Q1BF32_AMPOC/1-74    AC A0A3Q1BF32.1
#=GS A0A093SXI3_9PASS/1-41    AC A0A093SXI3.1
#=GS A0A402F4W2_9SAUR/1-78    AC A0A402F4W2.1
#=GS A0A099ZUT0_TINGU/1-79    AC A0A099ZUT0.1
#=GS W5PA81_SHEEP/1-93        AC W5PA81.1
#=GS A0A452DMS0_CAPHI/1-93    AC A0A452DMS0.1
#=GS A0A1L8GDL1_XENLA/1-76    AC A0A1L8GDL1.1
#=GS F6S7S9_HORSE/1-75        AC F6S7S9.2
#=GS A0A2Y9FBW1_PHYMC/1-75    AC A0A2Y9FBW1.1
#=GS G3GZ96_CRIGR/1-74        AC G3GZ96.1
#=GS A0A3Q2EET9_CYPVA/1-82    AC A0A3Q2EET9.1
#=GS Q9YGX8_CHICK/1-77        AC Q9YGX8.1
#=GS A0A384A1K8_BALAS/1-75    AC A0A384A1K8.1
#=GS M3XDS9_FELCA/1-74        AC M3XDS9.2
#=GS A0A2Y9P2F2_DELLE/1-76    AC A0A2Y9P2F2.1
#=GS A0A2I4BXL5_9TELE/1-73    AC A0A2I4BXL5.1
#=GS A0A3B3D556_ORYME/1-78    AC A0A3B3D556.1
#=GS K7FXT7_PELSI/1-61        AC K7FXT7.1
#=GS A0A1S3PTF9_SALSA/1-72    AC A0A1S3PTF9.1
#=GS M3ZCS6_XIPMA/1-89        AC M3ZCS6.2
#=GS A0A1U7QF69_MESAU/1-74    AC A0A1U7QF69.1
#=GS A0A4D9EWF5_9SAUR/1-77    AC A0A4D9EWF5.1
#=GS A0A0D9SD86_CHLSB/1-75    AC A0A0D9SD86.1
#=GS F1SGM9_PIG/1-94          AC F1SGM9.2
#=GS A0A3B3QEM8_9TELE/1-77    AC A0A3B3QEM8.1
#=GS A0A0Q3X8Z9_AMAAE/1-73    AC A0A0Q3X8Z9.1
#=GS A0A3L8RZ84_CHLGU/1-73    AC A0A3L8RZ84.1
#=GS A0A340Y953_LIPVE/1-76    AC A0A340Y953.1
#=GS H0XIB5_OTOGA/1-74        AC H0XIB5.1
#=GS A0A3B3YIQ8_9TELE/1-74    AC A0A3B3YIQ8.1
#=GS KCNA4_HUMAN/1-75         AC P22459.2
#=GS H3CW27_TETNG/1-71        AC H3CW27.1
#=GS A0A2D0Q7F2_ICTPU/1-75    AC A0A2D0Q7F2.1
#=GS A0A3P8Z9Z6_ESOLU/1-72    AC A0A3P8Z9Z6.1
#=GS U3KCM9_FICAL/1-76        AC U3KCM9.1
#=GS A0A3P8W1M1_CYNSE/1-78    AC A0A3P8W1M1.1
#=GS A0A060WYH4_ONCMY/1-68    AC A0A060WYH4.1
#=GS G3V6L7_RAT/1-74          AC G3V6L7.1
#=GS A0A3Q7U928_VULVU/1-40    AC A0A3Q7U928.1
#=GS A0A2Y9D873_TRIMA/1-74    AC A0A2Y9D873.1
#=GS A0A452RR53_URSAM/1-74    AC A0A452RR53.1
#=GS G1PSL7_MYOLU/1-76        AC G1PSL7.1
#=GS H2L6Y4_ORYLA/1-92        AC H2L6Y4.2
#=GS A0A2U3WU64_ODORO/1-75    AC A0A2U3WU64.1
#=GS U3I8V1_ANAPP/1-77        AC U3I8V1.2
#=GS G3U8V1_LOXAF/1-74        AC G3U8V1.1
#=GS A0A1S3FGK3_DIPOR/1-75    AC A0A1S3FGK3.1
#=GS A0A091D2U8_FUKDA/86-132  AC A0A091D2U8.1
#=GS A0A3B3VUY3_9TELE/1-77    AC A0A3B3VUY3.1
#=GS F1Q929_DANRE/1-74        AC F1Q929.2
#=GS A0A2U3XCC4_LEPWE/1-74    AC A0A2U3XCC4.1
#=GS A0A401NJ62_SCYTO/1-56    AC A0A401NJ62.1
#=GS F6RH21_ORNAN/1-78        AC F6RH21.1
#=GS A0A093JZ05_STRCA/1-77    AC A0A093JZ05.1
#=GS A0A218UJ52_9PASE/1-77    AC A0A218UJ52.1
#=GS KCNA4_MOUSE/1-74         AC Q61423.2
#=GS KCNA4_BOVIN/1-74         AC Q05037.1
#=GS F6V7J2_XENTR/1-87        AC F6V7J2.1
#=GS R0LGU6_ANAPL/1-77        AC R0LGU6.1
#=GS A0A091GDD7_9AVES/1-77    AC A0A091GDD7.1
#=GS A0A1A6H0M3_NEOLE/1-58    AC A0A1A6H0M3.1
#=GS G3W191_SARHA/1-76        AC G3W191.1
#=GS A0A1S3A7D5_ERIEU/1-74    AC A0A1S3A7D5.1
#=GS A0A1V4JP80_PATFA/1-73    AC A0A1V4JP80.1
#=GS A0A3Q7XMS6_URSAR/1-74    AC A0A3Q7XMS6.1
#=GS A0A060VM96_ONCMY/1-74    AC A0A060VM96.1
#=GS A0A091XHV4_OPIHO/1-77    AC A0A091XHV4.1
#=GS I3N544_ICTTR/1-94        AC I3N544.1
#=GS G5C6P0_HETGA/145-171     AC G5C6P0.1
#=GS I3JEP5_ORENI/1-77        AC I3JEP5.1
#=GS A0A087RKD6_APTFO/1-77    AC A0A087RKD6.1
#=GS A0A2U4CDF3_TURTR/1-76    AC A0A2U4CDF3.1
#=GS A0A3B4WXA1_SERLL/1-80    AC A0A3B4WXA1.1
#=GS A0A3Q2V8V7_HAPBU/1-74    AC A0A3Q2V8V7.1
#=GS A0A1U7RN15_ALLSI/1-92    AC A0A1U7RN15.1
#=GS A0A286XQP5_CAVPO/1-94    AC A0A286XQP5.1
#=GS A0A401SP06_CHIPU/1-68    AC A0A401SP06.1
#=GS A0A2Y9JQR5_ENHLU/1-74    AC A0A2Y9JQR5.1
#=GS KCNA4_MUSPF/1-74         AC Q28527.1
#=GS F7EUZ9_MONDO/1-77        AC F7EUZ9.1
#=GS A0A087XCV7_POEFO/1-88    AC A0A087XCV7.2
#=GS A0A1L8GJ31_XENLA/1-86    AC A0A1L8GJ31.1
#=GS KCNA4_RAT/1-74           AC P15385.1
#=GS KCNA4_RAT/1-74           DR PDB; 1KN7 A; 1-74;
#=GS KCNA4_RAT/1-74           DR PDB; 1ZTO A; 1-37;
#=GS F1PU39_CANLF/1-75        AC F1PU39.2
#=GS W5KF13_ASTMX/1-80        AC W5KF13.2
#=GS G1KA04_ANOCA/1-77        AC G1KA04.2
#=GS A0A093GLW5_DRYPU/1-95    AC A0A093GLW5.1
#=GS F6QDP8_MACMU/1-73        AC F6QDP8.1
#=GS H0Z2W9_TAEGU/1-97        AC H0Z2W9.1
#=GS F1MFZ3_BOVIN/1-75        AC F1MFZ3.1
#=GS A0A3M0JC75_HIRRU/1-77    AC A0A3M0JC75.1
#=GS A0A151MBP3_ALLMI/1-77    AC A0A151MBP3.1
A0A452GZY5_9SAUR/1-77               ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.AS.L..G..G.......G....S...yH....HYH..Q..VQ------sggasssh.........................
Q5REB6_PONAB/1-74                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
L5KX80_PTEAL/1-94                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGSCT--shdpqssrgsrrrrrqrpekkk...........
A0A091HNY4_CALAN/1-77               ........MEVAMVSADSSGCNTHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....NYHqeQ..SRGASSS-h................................
A0A3Q1ELJ4_9TELE/1-97               ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERererqaAAQSRAAAAAAAAEGG...CGAE..............GG.GG.G..G..G.......S....-....-....---..-..--------gggasvggststssgahllnnrqhqsraassse
F7IQA3_CALJA/1-74                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
A0A3Q1BF32_AMPOC/1-74               ........----MVGAD-GGCNSHLPYGY-AQARARERERererqaAAQSRAAAAAAEGGCG...AEGG..............GG.GG.G..G..G.......G....A....S....VG-..-..--------gstststssg.......................
A0A093SXI3_9PASS/1-41               ........MEVAMVSADSSGCNTHMPYGYAAQARARERER......LAHA------------...----..............--.--.-..-..-.......-....-....-....---..-..--------srsgl............................
A0A402F4W2_9SAUR/1-78               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE.............tGA.SG.G..G..G.......P....Y....H....HYH..Q..EQGR----gassssh..........................
A0A099ZUT0_TINGU/1-79               ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAGAGAAa.tAAVE.............aGA.AG.G..G..G.......P....H....H....HYHqeQ..SRGA----ssay.............................
W5PA81_SHEEP/1-93                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......G....A....H....HHH..P..SRGACTS-hdpqssrgsrrrrrqrpekk.............
A0A452DMS0_CAPHI/1-93               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......G....A....H....HHH..P..SRGACTS-hdpqssrgsrrrrrqrpekk.............
A0A1L8GDL1_XENLA/1-76               ........MEVAMVSADSSGCSNHLPYGY-AQARARERER......QAHSRAAAAAAASGEG...GNSG..............GG.AG.V..N..A.......R....R....A....PQN..Q..--------vpeqqeekssq......................
F6S7S9_HORSE/1-75                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GGgS..G..G.......G....S....H....HHH..Q..ARAACAS-h................................
A0A2Y9FBW1_PHYMC/1-75               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......G....A....H....HHH.hQ..LRGACTS-q................................
G3GZ96_CRIGR/1-74                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAGAAAT...AAVE..............GT.GG.S..G..G.......G....P....H....HHH..Q..MRGAYSSH.................................
A0A3Q2EET9_CYPVA/1-82               ........----MVGAD-GGCNSHLPYGY-AQARARERERer.erqVAQTRAAAVAASSEGG...SGAE.............gGA.GG.A..T..Sat...ssG....S....HllnnRQH..Q..PRAA----tsss.............................
Q9YGX8_CHICK/1-77                   ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....HYH..Q..EQGR----gasssh...........................
A0A384A1K8_BALAS/1-75               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......G....A....H....HHH.hQ..LRGACTS-q................................
M3XDS9_FELCA/1-74                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......S....S....H....HHH..Q..SRGACTS-h................................
A0A2Y9P2F2_DELLE/1-76               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....A....H....HHHhhQ..LRGACTS-q................................
A0A2I4BXL5_9TELE/1-73               ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERe...reRQASRAAAAAAAAEGA...EGGG..............GG.GG.G..G..G.......G....P....G....---..-..--------stassgahll.......................
A0A3B3D556_ORYME/1-78               ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERer.erqAAQSRAAAAAAATEGG...SAAE..............GG.GG.G..G..G.......H....-....-....---..-..--------gggsisttttsssah..................
K7FXT7_PELSI/1-61                   ........MEVAMVSAESSGCNSHMPYGYAVQARARERER......LAHSGGAS--------...----..............--.--.-..-..-.......-....-....-....---..-..--------ggggpyhhyhqiqsrgasssh............
A0A1S3PTF9_SALSA/1-72               ........MEFAMIGSD-NGCKTRLPYGY-ARAREREHER......ERQVQQATAAAEGAAT...GEGG..............ES.SG.H..L..L.......N....N....H....QQH..Q..SRTASSS-n................................
M3ZCS6_XIPMA/1-89                   ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERer.erqAAQSRAAAAAAAAAADg.gSCAE.............vGA.GG.P..T..Sat...ssG....AhllnN....RQH..Q..SRARKKQ-rg...............................
A0A1U7QF69_MESAU/1-74               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GT.GG.S..G..G.......G....P....H....HHH..Q..TRGAYSSH.................................
A0A4D9EWF5_9SAUR/1-77               ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.AS.L..G..G.......G....S...yH....HYH..Q..VQ------sggasssh.........................
A0A0D9SD86_CHLSB/1-75               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-hd...............................
F1SGM9_PIG/1-94                     ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....T....H....HHH..Q..SRGACTS-hdpqssrgsrrrrrqrpekkk............
A0A3B3QEM8_9TELE/1-77               ........MEFAMVGAESGGCNSHLPYGY-AQARARERERer..erQVQSRAAAA--AAEAG...STSE..............GQ.CC.T..ShhP.......N....N....H....QLH..Q..SRAASS--ch...............................
A0A0Q3X8Z9_AMAAE/1-73               ........----MVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....HYHqeQ..SRGASSS-h................................
A0A3L8RZ84_CHLGU/1-73               ........----MVSADSSGCNTHMPYGYAAQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AA.G..G..G.......G....P...yH....HYHqeQ..ARGAS---ssh..............................
A0A340Y953_LIPVE/1-76               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......G....A....H....HHHhhQ..LRGACTS-q................................
H0XIB5_OTOGA/1-74                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.P..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
A0A3B3YIQ8_9TELE/1-74               ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERer.erqVAHSRAAAAAAAA---...-AAD..............GG.SG.A..E..G.......G....E....P....EQQ..Q..QHRV----lrerk............................
KCNA4_HUMAN/1-75                    ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-hd...............................
H3CW27_TETNG/1-71                   ........MEFAMVGAD-GGCNSHLPYGY-AQARARERER......ERERQAAQA-GAGVGG...STSS..............SS.SC.A..H..L.......L....N....N....RQH..Q..SRVASS--an...............................
A0A2D0Q7F2_ICTPU/1-75               ........MEFAMVGADSSGCNPHLPYGY-AQARARERERe....rERHSRAAAAAAASEAG...AAGD..............GG.GG.G..G..S.......C....T....H....PYS..Q..PYQTR---tas..............................
A0A3P8Z9Z6_ESOLU/1-72               ........MEFAMIGAD-NGCKTRLPYGY-ARAREREHER......ERQVQQAAAAAEGA--...AS--..............GE.GG.E..S..S.......GhllnN....H....QQH..Q..SRTSS---ssn..............................
U3KCM9_FICAL/1-76                   ........MEVAMVSADSSGCNTHLPYGYAAQARARERER......LAQSRAAAAAAVGGGG...GGGG..............GG.GG.G..G..G.......G....D....H....HYHqeQ..SRGASSSQ.................................
A0A3P8W1M1_CYNSE/1-78               ........----MVGAD-GGCNSHLPYGY-AQARARERERer.erqVAHSRAAAAAAAATVD...GGLS..............AE.GG.A..G..G.......G....G....C....---..-..--------gggtggggsgyenayse................
A0A060WYH4_ONCMY/1-68               ........MEFAMIGSD-NGCKTRLPYGY-ARAREREHERe....rQHQSRTASSSNANNSS...GST-..............--.--.-..-..-.......-....-....-....---..-..--------hhheseqqvlrerkkqr................
G3V6L7_RAT/1-74                     ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GT.GG.S..G..G.......G....P....H....HHH..Q..TRGAYSSH.................................
A0A3Q7U928_VULVU/1-40               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAQSRG----------...----..............--.--.-..-..-.......-....-....-....---..-..--------gf...............................
A0A2Y9D873_TRIMA/1-74               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
A0A452RR53_URSAM/1-74               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
G1PSL7_MYOLU/1-76                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.P..G..G.......G....S....H....HHHhhQ..SRGACTS-h................................
H2L6Y4_ORYLA/1-92                   ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERer.erqAAQSRAAAAAAATDGG...PAAE..............GG.GG.GghG..G.......G....S....I....ST-..-..--------ttsssahllnnrqhqsraassst..........
A0A2U3WU64_ODORO/1-75               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.AG.S..G..G.......G....S....H....HHH..Q..ARGACTS-hd...............................
U3I8V1_ANAPP/1-77                   ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE.............aGA.TG.G..G..G.......P....Y....H....HYHqeQ..SRGASSS-h................................
G3U8V1_LOXAF/1-74                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACI--sq...............................
A0A1S3FGK3_DIPOR/1-75               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....P....H....HHH..Q..TRGACTS-hd...............................
A0A091D2U8_FUKDA/86-132             lntrpqta--------------------------------......---QGAAAAAAVAAAT...AAVE..............GT.GG.S..G..G.......G....S....H....HHH..Q..ARGACS--ah...............................
A0A3B3VUY3_9TELE/1-77               ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERer.erqVAHSRATAAAAAADGG...SGAE.............gGA.GG.P..T..S.......A....T....S....SVL..R..E-------rkkqrg...........................
F1Q929_DANRE/1-74                   ........MEFAMVGADSGGCNTHLPYGY-AQARARERERe....rERHSRAAAAAA-AEAG...AVGE..............GG.GS.T..G..H.......P....H....N....HPH..Q..SRAASS--tn...............................
A0A2U3XCC4_LEPWE/1-74               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.AG.S..G..G.......G....S....H....HHH..Q..ARGACTS-h................................
A0A401NJ62_SCYTO/1-56               ........----MVSVEGGGCNSHPPYGY-----AQRRER......LANSRAAAAVAAAAAG...SAHN.............qGG.GG.-..-..-.......-....-....-....---..-..--------rrrqgnpr.........................
F6RH21_ORNAN/1-78                   ........MEVAMVSAESSGCNSHLPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......Gs..gS....H....HHH..Q..PRGTA---scssq............................
A0A093JZ05_STRCA/1-77               ........MEVAMVSADSSGCNSHMPYGYAAQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....HYHqeQ..SRGASS--sy...............................
A0A218UJ52_9PASE/1-77               ........MEVAMVSADSSGCSTHMPYGYAAQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AA.G..G..G.......G....P...yH....HYHqeQ..ARGAS---ssh..............................
KCNA4_MOUSE/1-74                    ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GT.GG.S..G..G.......G....P....H....HHH..Q..TRGAYSSH.................................
KCNA4_BOVIN/1-74                    ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......S....Q....H....HHH..P..SRGACTS-h................................
F6V7J2_XENTR/1-87                   ........MEVAMVSADSSGCSSHLPYGY-AQARARERER......LAHSRAAAAAAAAGEG...GNSGggacqgagrapatqGN.SG.A..-..-.......-....-....-....---..-..--------ggnarrapqsqeqqeek................
R0LGU6_ANAPL/1-77                   ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE.............aGA.TG.G..G..G.......P....Y....H....HYHqeQ..SRGASSS-h................................
A0A091GDD7_9AVES/1-77               ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....HYHqeQ..SRGASSS-h................................
A0A1A6H0M3_NEOLE/1-58               ........----------------MPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GT.GG.S..G..G.......G....P....H....HHH..Q..TRGAYSSH.................................
G3W191_SARHA/1-76                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......Gs..gS....H....HHH..Q..NRGACSS-h................................
A0A1S3A7D5_ERIEU/1-74               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GI.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
A0A1V4JP80_PATFA/1-73               ........----MVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....HYHqeQ..SRGVSSS-h................................
A0A3Q7XMS6_URSAR/1-74               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
A0A060VM96_ONCMY/1-74               ........MEFAMIGAD-NGCKTRLPYGY-ARAREREHER......ERQSRTASSSNANNSS...GSTA.............sRP.SS.S..Q..Q.......P....Q....Q....HYH..E..SEQ-----qvlrer...........................
A0A091XHV4_OPIHO/1-77               ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....HYHqeQ..SRGASSS-h................................
I3N544_ICTTR/1-94                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..TRGACTS-hdpqssrgsrrrrrqrpekkk............
G5C6P0_HETGA/145-171                ........MEVAMVSAESSGCNSHLPYGQ-----------......----------------...----..............--.--.-..-..-.......-....-....-....---..-..--------eidrmq...........................
I3JEP5_ORENI/1-77                   ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERer.erqVAHTRAAAAAAAAEGG...TCTE..............GG.GG.G..G..G.......G....S....N....RQH..Q..SRAAQNQQ.................................
A0A087RKD6_APTFO/1-77               ........MEVAMVSTDSSGCNSHMPYGYAVQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....HYHqeQ..SRGASSS-h................................
A0A2U4CDF3_TURTR/1-76               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......G....A....H....HHHhhQ..LRGACTS-q................................
A0A3B4WXA1_SERLL/1-80               ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERer.erqAAQSRAAAAAAAAEGG...SGVE..............GG.GG.G..G..G.......G....G....G....---..-..--------vggstststststss..................
A0A3Q2V8V7_HAPBU/1-74               ........----MVGAD-GGCNSHLPYGY-AQARARERERer.erqAAHTRAAAAAAAAEGG...TCTE..............GG.GG.G..S..C.......G....G....-....---..-..--------vggstsntsssahl...................
A0A1U7RN15_ALLSI/1-92               ........MEVAMVSADSSGCNSHLPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GGaTG.G..E..G.......P....Y....H....HYH..Q..EQGR----gassscggnasrssqpqrqns............
A0A286XQP5_CAVPO/1-94               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT..aAAAE..............GS.GG.G..S..G.......G....S....H....HHH..Q..PRGAC---tahdpqgsrgsrrtrrqrpekk...........
A0A401SP06_CHIPU/1-68               ........MEVAMVSVEGGGCNTHPPYGY-AQ-------R......LANSRAAAAAAAAAANsghQAAA..............GV.GG.R..D..P.......A....P....C....NH-..-..--------nnggrrwrr........................
A0A2Y9JQR5_ENHLU/1-74               ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
KCNA4_MUSPF/1-74                    ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......G....S....H....HHH..Q..SRGACTS-h................................
F7EUZ9_MONDO/1-77                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..G..G.......Gs..gS....H....HHH..Q..TRGTCSS-hd...............................
A0A087XCV7_POEFO/1-88               ........MEFAMVGAD-GGCNSHLPYGY-AQARARERERer.erqVAHSRAAAAAAAAAAD...GGSG..............AE.GG.A..G..GptsatssG....AhllnN....RQH..Q..SRAASS--sa...............................
A0A1L8GJ31_XENLA/1-86               ........MEAAMVSVDSSGCSSHLPYGY-AQARARERER......LAHSRAAAAAAAGEGA...NSGG..............GA.CQ.G..A..G.......R....A....-....---..-..--------patqssggagtnarrapqsqvqeeqe.......
KCNA4_RAT/1-74                      ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GT.GG.S..G..G.......G....P....H....HHH..Q..TRGAYSSH.................................
#=GR KCNA4_RAT/1-74           SS    ........----------TTTTT-S-TTGGGCHHHHHHHH......HTTSSTTXXXHHHHSS...XSSX..............XX.XX.X..X..X.......X....X....X....XXS..X..XXXXXXXX.................................
F1PU39_CANLF/1-75                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAQSRAAAAAAVAAAT..aAAAE..............GV.GG.P..G..G.......G....A....H....QQH..Q..QHQQHQQQ.................................
W5KF13_ASTMX/1-80                   ........MEFAMVGADSGGCNPHMPYGY-AQARARERERe....rERHSRAAAAAAAAAAA..aAAADsg..........atGE.GG.G..T..G.......G....T....C....IHG..Q..QHQVRT--as...............................
G1KA04_ANOCA/1-77                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAQSRAAAAAAVAAAT...AAVE.............tGS.GG.G..G..G.......P....H....H....HYH..Q..EQGR----gassss...........................
A0A093GLW5_DRYPU/1-95               ........MEVAMVSADSSGCNSHMPYGYAVQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AT.G..G..G.......G....P...yH....HYH..QeeSRGAS---sshggnasrgsmphrqsgkrr............
F6QDP8_MACMU/1-73                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GS.GG.S..-..G.......G....S....H....HHH..Q..SRGACTS-h................................
H0Z2W9_TAEGU/1-97                   ........MEVAMVSADSSGCNTHMPYGYAAQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AA.G..G..G.......G....P...yH....HYHqeQ..ARGAS---sshggsasrgglpcrqsgkrrkk..........
F1MFZ3_BOVIN/1-75                   ........MEVAMVSAESSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GG.GG.S..G..G.......G....A....Q....HHH.hP..SRGACT--sh...............................
A0A3M0JC75_HIRRU/1-77               ........MEVAMVSADSSGCNTHMPYGYAAQARARERER......LAQSRAAAAAAVAAAT...AAVE..............GG.AA.G..G..G.......G....P...yH....HYHqeQ..SRGASSS-h................................
A0A151MBP3_ALLMI/1-77               ........MEVAMVSADSSGCNSHLPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............GGaTG.G..E..G.......P....Y....H....HYH..Q..EQG-----rggnasr..........................
#=GC SS_cons                        ........----------TTTTT-S-TTGGGCHHHHHHHH......HTTSSTTXXXHHHHSS...XSSX..............XX.XX.X..X..X.......X....X....X....XXS..X..XXXXXXXX.................................
#=GC seq_cons                       ........MEVAMVSA-SSGCNSHMPYGYAAQARARERER......LAHSRAAAAAAVAAAT...AAVE..............Gu.GG.u..G..G.......G....s....H....HaH..Q..sRGApt..p................................
//
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