GenomeNet

Database: Pfam
Entry: Knl1_RWD_C
LinkDB: Knl1_RWD_C
Original site: Knl1_RWD_C 
#=GF ID   Knl1_RWD_C
#=GF AC   PF18210.1
#=GF DE   Knl1 RWD C-terminal domain
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF01355
#=GF GA   25.00 25.00;
#=GF TC   27.80 25.40;
#=GF NC   24.30 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Kinetochore
#=GF RN   [1]
#=GF RM   24530301
#=GF RT   Modular assembly of RWD domains on the Mis12 complex underlies
#=GF RT   outer kinetochore  organization.
#=GF RA   Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K,
#=GF RA   Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S,
#=GF RA   Raunser S, Musacchio A;
#=GF RL   Mol Cell. 2014;53:591-605.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in Knl1, a sub-unit of the KMN network,
#=GF CC   present in Homo sapiens. The KMN network is the core of the
#=GF CC   outer kinetochore which is responsible for microtubule
#=GF CC   binding/stabilization and controls the spindle assembly
#=GF CC   checkpoint. This domain is the second of two RING finger, WD
#=GF CC   repeat, DEAD-like helicase (RWD) domains. The tandem RWD domains
#=GF CC   mediate kinetochore targeting of the microtubule-binding
#=GF CC   subunits by interacting with the Mis12 complex.  The Mis12
#=GF CC   complex is a KMN sub-complex that tethers directly onto the
#=GF CC   underlying chromatin layer [1].
#=GF SQ   111
#=GS H2UB46_TAKRU/355-454        AC H2UB46.1
#=GS A0A1S3WV00_ERIEU/924-1021   AC A0A1S3WV00.1
#=GS A0A2I2Y3R2_GORGO/2213-2310  AC A0A2I2Y3R2.1
#=GS F6ZH89_HORSE/2046-2143      AC F6ZH89.1
#=GS A0A2I3NGA3_PAPAN/2212-2237  AC A0A2I3NGA3.1
#=GS A0A1L8FB08_XENLA/2467-2535  AC A0A1L8FB08.1
#=GS A0A2K5IYS6_COLAP/2141-2181  AC A0A2K5IYS6.1
#=GS KNL1_HUMAN/2239-2336        AC Q8NG31.3
#=GS KNL1_HUMAN/2239-2336        DR PDB; 4NF9 B; 2213-2310;
#=GS KNL1_HUMAN/2239-2336        DR PDB; 4NFA A; 2213-2310;
#=GS KNL1_HUMAN/2239-2336        DR PDB; 4NF9 A; 2213-2310;
#=GS A0A091VYD7_NIPNI/359-456    AC A0A091VYD7.1
#=GS F1R5N3_DANRE/1695-1794      AC F1R5N3.1
#=GS S7P8D0_MYOBR/1233-1260      AC S7P8D0.1
#=GS A0A093JK68_STRCA/346-443    AC A0A093JK68.1
#=GS H0YCZ2_HUMAN/1258-1355      AC H0YCZ2.1
#=GS W5JXR3_ASTMX/1245-1343      AC W5JXR3.1
#=GS A0A091VT07_OPIHO/357-454    AC A0A091VT07.1
#=GS W5N4R8_LEPOC/2380-2479      AC W5N4R8.1
#=GS A0A093BVX4_9AVES/367-464    AC A0A093BVX4.1
#=GS A0A2K5IY49_COLAP/2127-2158  AC A0A2K5IY49.1
#=GS A0A087YEH3_POEFO/416-515    AC A0A087YEH3.1
#=GS A0A2I3TPF3_PANTR/2238-2335  AC A0A2I3TPF3.1
#=GS A0A2D0Q2R0_ICTPU/1507-1606  AC A0A2D0Q2R0.1
#=GS A0A091KH97_9GRUI/356-453    AC A0A091KH97.1
#=GS A0A091P854_APAVI/355-452    AC A0A091P854.1
#=GS A0A1U7S5C9_ALLSI/2443-2540  AC A0A1U7S5C9.1
#=GS W4YQ16_STRPU/537-635        AC W4YQ16.1
#=GS A0A226MLJ9_CALSU/173-270    AC A0A226MLJ9.1
#=GS U3IA34_ANAPL/2167-2264      AC U3IA34.1
#=GS S7P8D0_MYOBR/1255-1289      AC S7P8D0.1
#=GS I3JE18_ORENI/424-523        AC I3JE18.1
#=GS A0A091MCU0_9PASS/347-444    AC A0A091MCU0.1
#=GS A0A091DLD4_FUKDA/2091-2188  AC A0A091DLD4.1
#=GS G3WRH3_SARHA/2136-2233      AC G3WRH3.1
#=GS A0A1V4JR57_PATFA/1105-1202  AC A0A1V4JR57.1
#=GS H2QZH8_PANTR/2212-2309      AC H2QZH8.2
#=GS A0A1S3MA81_SALSA/1749-1848  AC A0A1S3MA81.1
#=GS A0A2B4SNA4_STYPI/1653-1735  AC A0A2B4SNA4.1
#=GS A0A0F8AG17_LARCR/1601-1700  AC A0A0F8AG17.1
#=GS A0A087RAK0_APTFO/371-468    AC A0A087RAK0.1
#=GS A0A2I0LQ57_COLLI/1828-1925  AC A0A2I0LQ57.1
#=GS A0A287D798_ICTTR/1670-1767  AC A0A287D798.1
#=GS A0A1S3EML5_DIPOR/1857-1954  AC A0A1S3EML5.1
#=GS A0A0Q3PPV1_AMAAE/1524-1621  AC A0A0Q3PPV1.1
#=GS I3JE19_ORENI/259-358        AC I3JE19.1
#=GS M3YAV9_MUSPF/1156-1253      AC M3YAV9.1
#=GS A0A1U7Q736_MESAU/1731-1828  AC A0A1U7Q736.1
#=GS G3RZG9_GORGO/2239-2336      AC G3RZG9.2
#=GS A0A093BJV5_CHAPE/354-451    AC A0A093BJV5.1
#=GS L5K4Y5_PTEAL/2142-2239      AC L5K4Y5.1
#=GS G5BLZ4_HETGA/2155-2252      AC G5BLZ4.1
#=GS A0A1D5QV87_MACMU/2229-2326  AC A0A1D5QV87.1
#=GS A0A091E8S2_CORBR/366-463    AC A0A091E8S2.1
#=GS H2NMU8_PONAB/2261-2294      AC H2NMU8.1
#=GS A0A2I4BSX9_9TELE/1518-1617  AC A0A2I4BSX9.1
#=GS A3KGI3_MOUSE/2021-2118      AC A3KGI3.1
#=GS F6WAJ3_MONDO/2163-2260      AC F6WAJ3.2
#=GS A0A091TTX1_9AVES/347-444    AC A0A091TTX1.1
#=GS A0A1U7RVG0_ALLSI/2431-2528  AC A0A1U7RVG0.1
#=GS A0A0P7VVR1_9TELE/172-216    AC A0A0P7VVR1.1
#=GS H2NMU8_PONAB/2238-2264      AC H2NMU8.1
#=GS A0A2D0Q3Z5_ICTPU/1506-1605  AC A0A2D0Q3Z5.1
#=GS A0A094MDV2_ANTCR/361-458    AC A0A094MDV2.1
#=GS M3XFC5_FELCA/2238-2335      AC M3XFC5.2
#=GS A0A2G9SEW9_LITCT/22-119     AC A0A2G9SEW9.1
#=GS G3NXF2_GASAC/366-465        AC G3NXF2.1
#=GS M3ZZP1_XIPMA/405-504        AC M3ZZP1.1
#=GS D3ZNX2_RAT/2016-2113        AC D3ZNX2.2
#=GS A0A099Z859_TINGU/362-459    AC A0A099Z859.1
#=GS F1RBJ1_DANRE/1578-1677      AC F1RBJ1.2
#=GS A0A1D5Q7B6_MACMU/2213-2310  AC A0A1D5Q7B6.1
#=GS A0A2D0Q6P5_ICTPU/1505-1604  AC A0A2D0Q6P5.1
#=GS F7F0K9_ORNAN/384-481        AC F7F0K9.2
#=GS G1QS69_NOMLE/2228-2325      AC G1QS69.2
#=GS M7AUY6_CHEMY/1720-1756      AC M7AUY6.1
#=GS H2UB47_TAKRU/228-327        AC H2UB47.1
#=GS K7G1Q5_PELSI/2206-2303      AC K7G1Q5.1
#=GS A0A0A0B0A4_CHAVO/376-473    AC A0A0A0B0A4.1
#=GS A0A091L9Y9_CATAU/361-458    AC A0A091L9Y9.1
#=GS A0A151MV47_ALLMI/1593-1690  AC A0A151MV47.1
#=GS A0A218UVK2_9PASE/1285-1382  AC A0A218UVK2.1
#=GS G1MF14_AILME/968-1065       AC G1MF14.1
#=GS A0A091UQI3_PHALP/359-456    AC A0A091UQI3.1
#=GS H2MTU2_ORYLA/354-453        AC H2MTU2.1
#=GS A0A2K5N0S8_CERAT/2200-2297  AC A0A2K5N0S8.1
#=GS A0A1U7UL77_TARSY/2198-2295  AC A0A1U7UL77.1
#=GS A0A094LVR5_9AVES/375-472    AC A0A094LVR5.1
#=GS A0A2K5IY49_COLAP/2158-2198  AC A0A2K5IY49.1
#=GS A0A1L1RJ22_CHICK/242-339    AC A0A1L1RJ22.1
#=GS E2RC04_CANLF/2171-2268      AC E2RC04.2
#=GS A0A093QPZ2_PYGAD/357-454    AC A0A093QPZ2.1
#=GS G3TPM1_LOXAF/234-331        AC G3TPM1.1
#=GS A0A093IGA4_DRYPU/368-465    AC A0A093IGA4.1
#=GS A0A087VRM1_BALRE/362-459    AC A0A087VRM1.1
#=GS W5QG94_SHEEP/2246-2343      AC W5QG94.1
#=GS A0A1S3HL39_LINUN/853-948    AC A0A1S3HL39.1
#=GS G1TA60_RABIT/2173-2270      AC G1TA60.2
#=GS C3Z3N5_BRAFL/1614-1701      AC C3Z3N5.1
#=GS U3JEG9_FICAL/52-149         AC U3JEG9.1
#=GS G1PQP6_MYOLU/2073-2170      AC G1PQP6.1
#=GS A0A093F7A1_GAVST/362-459    AC A0A093F7A1.1
#=GS A0A2K5IYS6_COLAP/2110-2141  AC A0A2K5IYS6.1
#=GS A0A091JIB3_EGRGA/357-454    AC A0A091JIB3.1
#=GS A0A226NFI7_COLVI/276-373    AC A0A226NFI7.1
#=GS H3C760_TETNG/229-328        AC H3C760.1
#=GS G3HYS5_CRIGR/15-112         AC G3HYS5.1
#=GS A0A287A512_PIG/199-296      AC A0A287A512.1
#=GS F6YXN8_XENTR/2154-2251      AC F6YXN8.1
#=GS A0A151MUX0_ALLMI/2061-2158  AC A0A151MUX0.1
#=GS A0A286Y2U7_CAVPO/2102-2185  AC A0A286Y2U7.1
#=GS A0A096NTH1_PAPAN/2249-2300  AC A0A096NTH1.2
#=GS A0A091FVY8_9AVES/371-468    AC A0A091FVY8.1
#=GS A0A091RIQ9_9GRUI/280-377    AC A0A091RIQ9.1
H2UB46_TAKRU/355-454                   .....................LGEELRLLRTWGGlRLEILH.IGCVDTLIHIVFSSLRKFAKFEVIFSVAlSGHH.YVLR.V.H.SFENMIGDTTLQQVEQVVASLSPGKNLLTKTVKKMFENLLR................
A0A1S3WV00_ERIEU/924-1021              .....................LGEEIEFLKRWGP.NYNLMN.IDVNNTELKLLFSSSAAFTKFEITLSLT.ANYP.SVQL.P.L.SIHIHLGDIGKDEITAVLSKVPQKDNYLKNVVKHIYQDLLQ................
A0A2I2Y3R2_GORGO/2213-2310             .....................LGEEIEYLKRWGP.NYNLMN.IDINNNELRLLFSSSAAFAKFEITLFLS.AYYP.SVPL.P.S.TIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQ................
F6ZH89_HORSE/2046-2143                 .....................LGEEIEFLKRWGP.NYNLMN.IDVNNTELRLLFSSSAAFSKFEITLSLS.ALYP.SVPL.T.F.SIQNHIGNIGQNEITTILSKVPLEDNYLKNVVKQVYRDLLQ................
A0A2I3NGA3_PAPAN/2212-2237             .....................LGEEIEYLKRWGP.NYNLMN.IDVNNTE---------------------.----.----.-.-.-----------------------------------------................
A0A1L8FB08_XENLA/2467-2535             ............lcikfgdvv-------------.------.-----GKVKLLFSSSLAYAKFELALHLS.ESYP.TLPL.T.F.TFQNHIGKIGD------------------------------iigsrhifsnlsdrpn
A0A2K5IYS6_COLAP/2141-2181             ..............ryklgtl-------------.------.----------------------------.----.----.-.-.-------NNSQDDVAAILSKVPLENNYLKNVVKQIYQDLFQ................
KNL1_HUMAN/2239-2336                   .....................LGEEIEYLKRWGP.NYNLMN.IDINNNELRLLFSSSAAFAKFEITLFLS.AYYP.SVPL.P.S.TIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQ................
#=GR KNL1_HUMAN/2239-2336        SS    .....................HHHHHHHHHHHGG.GGTEEE.EEEETTEEEEEEEETTTTEEEEEEEE--.TTTT.SS--.-.E.EEEEEES---HHHHHHHHTTS-SSTTHHHHHHHHHHHHHT-................
A0A091VYD7_NIPNI/359-456               .....................LGEEIEFLERWGG.KFNLLK.TDINDTKVKLLFSASTAFAKFELTLALS.ANYP.SASL.P.F.TVQKQIGNIGEEEISAVLSSVPIGYHYLRRIVSLIHQNLLQ................
F1R5N3_DANRE/1695-1794                 .....................LGEEIHRLKKWGGlRLRILK.ITCTDTRVHVIFSSLKSFEKFELSLTVT.PDYP.FGPL.H.IqDFKNHMGNTRLDQLEEIISSVKPAKNYLSKILKKIHDDLL-c...............
S7P8D0_MYOBR/1233-1260                 .....................LGEEIEFLKRWGP.NYKLMN.IDVNNTD---------------------.----.----.-.-.-----------------------------------------hd..............
A0A093JK68_STRCA/346-443               .....................LGEEIEFLKRWGG.KFNLLK.TDINDTKVKLLFSTSTAFAKFELTLSLS.ANYP.SASL.P.F.TVQSQIGNIGEEEISAVLSKVPLGYHYLRRIVSLIHHHLLQ................
H0YCZ2_HUMAN/1258-1355                 .....................LGEEIEYLKRWGP.NYNLMN.IDINNNELRLLFSSSAAFAKFEITLFLS.AYYP.SVPL.P.S.TIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQ................
W5JXR3_ASTMX/1245-1343                 .....................LGEEIHQLKKWGGlRFDILH.FNCSDTLVEIVFSSIKACAKFELSLTVT.PDYP.LNPL.Q.MqKFQNLIGKTRVDQIEDVLCSVTPAKNYLTNLIKKIHADLL-................
A0A091VT07_OPIHO/357-454               .....................LGDEIEFLERWGG.KFNLLK.TEISDTKVKLLFSASPAFAKFELTLSLS.ANYP.SAPL.P.F.TVQKKIGNIGEKEVSAVLSSVPVGYHYLQRIVSSIHQNLLQ................
W5N4R8_LEPOC/2380-2479                 .....................LGQELRYLKKWGPlKFDILE.MTLLDTHVKILFSSVKGFAKFEITLALT.PAYP.FSRL.VlL.DFKNYIGNLRWEQIEEVLCAVQPENDYLTRIVEKIHLNLL-t...............
A0A093BVX4_9AVES/367-464               .....................LGEEIEFLERWGG.KFNLLK.VDINDTKVKLLFSASMAFAKFELTLSLA.ANYP.SAPL.P.F.TVRKQIGNIGEEEIAAVLSNVPVGYHYLRRTVSLIHQNLLQ................
A0A2K5IY49_COLAP/2127-2158             .....................LGEEIEYLKRWGP.NYNLMN.IDVHNTETA-------------------.----.----.-.-.-----------------------------------------mter............
A0A087YEH3_POEFO/416-515               .....................VGEELRLLKMWGNlRFDILH.ISCSHTQIHVVFSSLRKLSKFEVVFGVRlTDQI.CVFH.V.Q.SFKNLIGNTTIQQIEEVVASLSPGRDLFTRIIKKIHETLL-s...............
A0A2I3TPF3_PANTR/2238-2335             .....................LGEEIEYLKRWGP.NYNLMN.IDINNNELRLLFSSSAAFAKFEITLFLS.AYYP.SVPL.P.S.TIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQ................
A0A2D0Q2R0_ICTPU/1507-1606             .....................LGEEIYRLKKWGGvRLGILH.ITCVDTLVEVMFSSVRAFVKFELSLAVT.PDYP.FRPL.Q.LqRFQNHIGDTRLEQVKDIISSVRPAKNYLTTVMKRIHSNLL-g...............
A0A091KH97_9GRUI/356-453               .....................LGEEIEFLERWGG.KFNLLK.TDIDDTKVKLLFSASAVFAKFELTLSLS.ANYP.SASL.P.F.TVQKQIGNIGEEEVSAVLSNVPTGYHYLRRIVSLIHQDLLQ................
A0A091P854_APAVI/355-452               .....................LGEEIEFLERWGG.KFNLLK.TDIDETKVKLLFSAATAFAKFELTLCLS.ASYP.AAPL.P.F.TVQSQIGNIGEKEVSAVLSSVPVGHHYLRRIVSLIHHHLLQ................
A0A1U7S5C9_ALLSI/2443-2540             .....................LGEEIEFLMKWGG.KFNLLK.TEVDDTKVKLLFSTSTAFAKFEVTLSLS.ATYP.SAPL.P.F.TVQKLIGNLSQEEISAVVSSVPLGTNYLRRMVKLIHHKL--fp..............
W4YQ16_STRPU/537-635                   lagqarlleaevsridfwhpv-------------.------.-TTAHNRLSIEFSSIEAHSMFCIHLDVVpGQYP.LTAI.P.H.SCVIKIGKISEESINATIDTVQPGWSYVTRITKAIEQ----llh.............
A0A226MLJ9_CALSU/173-270               .....................LGEEIQFLERWGG.KYNLLK.TDIVDTNVKLLFSSSTASAKFELTLSLS.SSYP.SSSL.P.F.TVEKKIGKIGREEISAVLSEVPAGYHYLRRMVSSIHQSLLQ................
U3IA34_ANAPL/2167-2264                 .....................LGEEIEFLERWGG.KFNLLK.TDINDTNLKLLFSSSTAFAKFEVTLSLS.SNYP.ATSL.P.F.TVQKQIGNIGHEEISAVLSNVPVGYHYLRRMVSLIHQNLLQ................
S7P8D0_MYOBR/1255-1289                 ....................n-------------.------.----------------------------.----.----.-.-.-------NTDHDEIFALLSKVPLEDNYLKNVVKQIYQDLLQ................
I3JE18_ORENI/424-523                   .....................LGEELRLLKLWGGlRLDILD.ISCMDTKVRIVFSSLKKFSKFEVVFAIClINHF.CVLQ.V.E.SFKNIIGSTTIQQIEDIVASFTPAKNLLTKTVRKIHEVLL-c...............
A0A091MCU0_9PASS/347-444               .....................LGEEVEFLERWGG.KFNLLK.TEIKDTEVKLLFSASAAFAKFELSLPLS.ASYP.SAPL.P.F.SVQTRIGNIGEKEVSAVLSSVPVGHRYLRRIVTSIHQNLLQ................
A0A091DLD4_FUKDA/2091-2188             .....................LGEEIEFLKSWGP.NYNLMD.IHVNNTELRLLFSSSAAFAKFEITLSLS.AHYP.LVPL.P.F.TIQNHLGNTGQDEIASIISKVPLEDNYLKNLVKQISRDLLQ................
G3WRH3_SARHA/2136-2233                 .....................LGEEIEFLNRWGP.NYNLMN.IDVNNTELKLLFSSTAAFAKFELTLTLS.AHYP.SVPL.S.F.TIQNIIGNVSQDQIAAILSNVPLDNNYLKTAIKCIYQDLLQ................
A0A1V4JR57_PATFA/1105-1202             .....................LGEEIDFLERWGG.KFNLLQ.TDVNDTEVKLLFSASAAFAKFELTLSLS.ASYP.SASL.P.F.TVRKQIGNIGEEEISAVLSSVPSGYHYLRRIVSLIHQTLLQ................
H2QZH8_PANTR/2212-2309                 .....................LGEEIEYLKRWGP.NYNLMN.IDINNNELRLLFSSSAAFAKFEITLFLS.AYYP.SVPL.P.S.TIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQ................
A0A1S3MA81_SALSA/1749-1848             .....................LGEEIHLMKKWGAlRLDILD.ISCVDTQVRILFSSLKSFSKFEMTVAVT.SAYP.FGLFhV.Q.NFQNHIGNTTKDQVEDIVSSVTPAKNYLTKIVKRIHESLL-c...............
A0A2B4SNA4_STYPI/1653-1735             ............glshlmsfe-------------.------.----KDRLVVEFSSLKAFVKFVLHVQVGfSSYP.NCV-.S.L.TALPKIGHLSRTEIEETLKAVSVGPRYLSRLVEA-------adqlls..........
A0A0F8AG17_LARCR/1601-1700             .....................LGEELRLLKMWGSlKLDILD.ISCIDTRVHIVFSSLKKFSKFEVIFSVSlTNHL.CALQ.V.Q.SFKNMIGNTTIQQIEEIVASFVPGKKLLTKIVKKIHESLL-c...............
A0A087RAK0_APTFO/371-468               .....................LGEEIEFLERWGG.KFNLLK.TDINDTKVKLLFSASTAFAKFELTLSLS.ANYP.SASL.P.F.TVQNQIGNIGEEEISAVLSNVPIGYHYLRRIVSLIHQNLLQ................
A0A2I0LQ57_COLLI/1828-1925             .....................LGEEIEFLQRWGG.KFNLLK.TDVNDTEVKLLFSTSAAFAKFELTLSLS.AGYP.SAAL.P.F.AVRKQIGNIGEEQISAVLSSVPSGYHYLRRIVSLIHQNLLQ................
A0A287D798_ICTTR/1670-1767             .....................LGEEIEFLKKWGP.NYNLMD.IDVNNTELKLLFSSSVAFAKFAVTLSLS.AHYP.LVPL.P.F.TIQNHLGNTSQDEIAAVIHKVPLADNYLKNIVKQIYQDLLQ................
A0A1S3EML5_DIPOR/1857-1954             .....................LGEEIEFLKRWGP.NYNLMY.IDVKHSELKLLFSSSVAFAKFELTLSVS.AYYP.LVPL.P.F.TVQNHLGNIGHDEIATIMSKVPLEDNYLKNIVKQIYQDLLQ................
A0A0Q3PPV1_AMAAE/1524-1621             .....................LGEEMDYLERWGG.KFNLLK.TEISDTKVKLLFSASKVFAKFGLTLSLS.ATYP.SAPL.P.F.TVQHQVGNIGEEEISAVVSKVPVGYHYLRRIVSSIHQSLLQ................
I3JE19_ORENI/259-358                   .....................LGEELRLLKLWGGlRLDILD.ISCMDTKVRIVFSSLKKFSKFEVVFAIClINHF.CVLQ.V.E.SFKNIIGSTTIQQIEDIVASFTPAKNLLTKTVRKIHEVLL-c...............
M3YAV9_MUSPF/1156-1253                 .....................LGEEIEFLKRWGP.NYNLMN.IDVTNTELRLLFSSSTAFAKFEITLPLS.VHFP.TVPL.P.F.SIQNHLGIIGQDEITAILSKVPLDDNYLKNVVKQIYQDLLQ................
A0A1U7Q736_MESAU/1731-1828             .....................LGEEIEFLKRWGP.NYCLMD.INMNNTELRLLFSSSAAFAKFEITFSLS.AHYP.LAPL.P.F.TIQNHLGNTGHEEIAAIISKVPLEDNYLKNVVKQIYQDVLK................
G3RZG9_GORGO/2239-2336                 .....................LGEEIEYLKRWGP.NYNLMN.IDINNNELRLLFSSSAAFAKFEITLFLS.AYYP.SVPL.P.S.TIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQ................
A0A093BJV5_CHAPE/354-451               .....................LGKEIEFLERWGG.KFNLLK.TDIRDTKVKLLFSSLAAFAKFELTLSLS.ANYP.ADSP.P.F.TVHKKIGNIGEEEISAVLSEVPPGHHYLRRAVSLIHQHLLQ................
L5K4Y5_PTEAL/2142-2239                 .....................LGEEIEFLKRWGP.NYNLMN.IDVNNTELKLLFSSSAAFAKFEITLSLS.VHYP.SVPL.L.F.SIQNHLGNIGRDEIAALLSKVPLEDNYLKNVVKQIYQDLLQ................
G5BLZ4_HETGA/2155-2252                 .....................LGEEIEFLKKWGP.NYNLMD.IYVNNTELRLLFSSSAAFAKFEITLSLS.AHYP.LVPL.P.F.TIQNHLGNTGQDEIASIISKVPLEDNYLKNIVKQISQDLLQ................
A0A1D5QV87_MACMU/2229-2326             .....................LGEEIEYLKRWGP.NYNLMN.IDVNNTELRLLFSSSAAFAKFEITLSLS.AYYP.SVPL.P.S.TIQNHIGNTSQDDIAAILSKVPLENNYLKNVVKQIYQDLFQ................
A0A091E8S2_CORBR/366-463               .....................LGEELEFLERWGA.KFHLLE.TDVKNTEVKLVFSSSVAFAKFELSLALS.HDYP.SAAL.P.F.SVQTHIGNIGEKEIAAVLSGVPVGHHYLQRIVFSIHQNLLQ................
H2NMU8_PONAB/2261-2294                 ...................nn-------------.------.----------------------------.----.----.-.-.---------DQDDIATILSKVPLENNYLKNVVKQIYQDLFQ................
A0A2I4BSX9_9TELE/1518-1617             .....................LGEELRLLKMWGAlRFDILD.ISSTETQVRIVFSSLKKMTKFEVVFSVSlMNQL.CVFH.V.Q.SFKNRFGNTTIQQMEEIVASVSSDTKLFTQIVTKIHNTLF-s...............
A3KGI3_MOUSE/2021-2118                 .....................LGEEIEFLKRWGP.NYSLMH.INVNNTELRLLFSSCAAFAKFEITLSPS.AHYP.LVPL.P.F.TIHNHIGKTGHDEIAAIISKVPLEENYLKNVVKQIYQDLLK................
F6WAJ3_MONDO/2163-2260                 .....................LGEEIEYLSRWGP.KFNLMN.VDVNNTQVQLLFSSSAAFAKFELTLSLS.AHYP.SVPV.S.F.TIQNLIGNTAQDKIAAILSKVPLDNNYLKTAVKYIYQDLLQ................
A0A091TTX1_9AVES/347-444               .....................LGEEIEFLERWGG.KFNLLK.MDINDTKVKLLFSASTAFAKFELTLTLS.ANYP.SASL.P.F.TVQNQIGNIGEEEISAVLSSVPVGSHYLRRIVSLIHQNLLQ................
A0A1U7RVG0_ALLSI/2431-2528             .....................LGEEIEFLMKWGG.KFNLLK.TEVDDTKVKLLFSTSTAFAKFEVTLSLS.ATYP.SAPL.P.F.TVQKLIGNLSQEEISAVVSSVPLGTNYLRRMVKLIHHKL--fp..............
A0A0P7VVR1_9TELE/172-216               .....................LGEEIHRLKKWGSlKLDIME.IACKDKQIKILFSSLKVFAKFEVTL---.----.----.-.-.-----------------------------------------................
H2NMU8_PONAB/2238-2264                 .....................LGEEIEYLKRWGP.NYNLMN.IDINNN----------------------.----.----.-.-.-----------------------------------------dq..............
A0A2D0Q3Z5_ICTPU/1506-1605             .....................LGEEIYRLKKWGGvRLGILH.ITCVDTLVEVMFSSVRAFVKFELSLAVT.PDYP.FRPL.Q.LqRFQNHIGDTRLEQVKDIISSVRPAKNYLTTVMKRIHSNLL-g...............
A0A094MDV2_ANTCR/361-458               .....................LGEEIEFLERWGG.KFNLLK.TDIDDTKVKLLFSASAAFAKFELTLSLS.ANYP.AASL.P.F.TVQKQIGNIGEEEISAVLSSVPTGHHYLRRMVSLIHHNLLQ................
M3XFC5_FELCA/2238-2335                 .....................LGEEIEFLKRWGP.NYNLMN.IDVTNTELRLLFSSSAAFAKFEITLPLS.VHFP.TVRL.P.F.SIQNHLGNIGQDEITAILSKVPLEDNYLKNVVKQIYQDLLQ................
A0A2G9SEW9_LITCT/22-119                .....................LGEEVEYLMKWGA.KYNIVR.TDVKSNEVKLLFSSTAAFAKFELSIQIS.EMYP.TDPL.S.F.TVLNRIGNTEYSRVAAAISKVPVGLWLLKRAVKSIHEHLL-v...............
G3NXF2_GASAC/366-465                   .....................LGEELRLLELWGGlRLDILH.ISCLDTRVHIVFSRLKAFSKFEVIFSVSlVNHL.YVLQ.V.Q.SFKNVIGNTTIQQIEEIVSSFSPAKNVLTKIIKRIHDDLL-c...............
M3ZZP1_XIPMA/405-504                   .....................VGEELRLLKMWGSlRFDILH.ISCSQTQIHIVFSSLKKLSKFDVVFGIRlTDQI.CVFH.V.Q.SFKNLIGNTTIQQIEEVVASLSPGRNLFTRIIRKLHETLL-s...............
D3ZNX2_RAT/2016-2113                   .....................LGEEIEFLKRWGP.NYSLMH.INVNNTELRLLFSSSAAFAKFEITLFPS.AHYP.LVPL.P.F.TIQNHLGKTGHDEIAAVISKVPLEENYLKNVVKQIYQDLLK................
A0A099Z859_TINGU/362-459               .....................LGEEIEFLEKWGG.KFNLLK.TDINNTEVKLLFSSSTAFAKFTLTLSLS.ANYP.SASL.P.F.TAQTKIGNIGEEEISAVLSKVPTGYHYLRRMVSSIHQNLLQ................
F1RBJ1_DANRE/1578-1677                 .....................LGEEIHRLKKWGGlRLRILK.ITCTDTRVHVIFSSLKSFEKFELSLTVT.PDYP.FGPL.H.IqDFKNHMGNTRLDQLEEIISSVKPAKNYLSKILKKIHDDLL-c...............
A0A1D5Q7B6_MACMU/2213-2310             .....................LGEEIEYLKRWGP.NYNLMN.IDVNNTELRLLFSSSAAFAKFEITLSLS.AYYP.SVPL.P.S.TIQNHIGNTSQDDIAAILSKVPLENNYLKNVVKQIYQDLFQ................
A0A2D0Q6P5_ICTPU/1505-1604             .....................LGEEIYRLKKWGGvRLGILH.ITCVDTLVEVMFSSVRAFVKFELSLAVT.PDYP.FRPL.Q.LqRFQNHIGDTRLEQVKDIISSVRPAKNYLTTVMKRIHSNLL-g...............
F7F0K9_ORNAN/384-481                   .....................LGDEIEFLSRWGP.KYSLIK.IAVNGNEVKLLFSSTASFAKFELTMSLS.ASYP.MVPL.P.F.TFQNRIGKISQDDVAAVLSRVPLGSNYLKTAVQLIHRDLLQ................
G1QS69_NOMLE/2228-2325                 .....................LGEEIEYLKRWGP.NYNLMN.IDINNTELRLLFSSSAAFAKFEITLFLS.AYYP.SVPL.P.S.TIQNHIGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQ................
M7AUY6_CHEMY/1720-1756                 .....................LGEEIVFLNRWGG.KFNLLK.TEVDNTNPGL------------------.----.----.-.-.-----------------------------------------isiqigif........
H2UB47_TAKRU/228-327                   .....................LGEELRLLRTWGGlRLEILH.IGCVDTLIHIVFSSLRKFAKFEVIFSVAlSGHH.YVLR.V.H.SFENMIGDTTLQQVEQVVASLSPGKNLLTKTVKKMFENLLR................
K7G1Q5_PELSI/2206-2303                 .....................LGEEIEFLNRWGG.KCNLLK.TEVDNTKVKLLFSSCTAFAKFEVIFSLS.ANYP.STPL.Q.F.TVQKQIGSLGHDEISAVLSSVPLGTNYLKRMVKMIHHNLLQ................
A0A0A0B0A4_CHAVO/376-473               .....................LGEEIEFLERWGG.KFNLLK.TEVDDTKVKLLFSASAAFAKFELTLSLS.ADYP.SASL.P.F.TVQKQIGNIGEEEISAVLSSVPIGYHYLRRIVSLIHQNLLQ................
A0A091L9Y9_CATAU/361-458               .....................LGEEIEFLERWGG.KFHLLK.TDISDTKVKLLFSASTAFAKFELTLSLS.ANYP.SASL.P.F.TVQNQIGNIGEEEISAVLSNVPVGYHYLRRIVSLIHQNLLQ................
A0A151MV47_ALLMI/1593-1690             .....................LGEEIEFLMKWGG.KFNLLK.TEVDDTKVKLLFSTSTAFAKFEVTLSLS.ATYP.SAPL.P.F.TVQKLIGNLSQDEISAVVSSVPLGTNYLRRMVKLIHHKL--fp..............
A0A218UVK2_9PASE/1285-1382             .....................LGEELEFLQRWGA.KFQLLE.ADIKDTEVKLLFSSSVAFAKFELILTLS.HDYP.SAVL.P.F.RVQTHIGTIGEKEIAAVLSRVPAGHHYLQRAVVSIHQNLLQ................
G1MF14_AILME/968-1065                  .....................LGEEIEFLKRWGP.NYNLMN.IDVTNTELRLLFSSSTAFAKFEMTLPLS.VHFP.TVPL.P.F.SIQNHLGNIGQDEVTAILAKVPLEDNYLKNVVKQIYQDLLQ................
A0A091UQI3_PHALP/359-456               .....................LGEEIEFLERWGG.KFNLLK.TDINDTKVKLLFSASIAFAKFELTLSLS.DDYP.SASL.P.F.TVQKQIGNIGEEEISAVLSNVPTGYHYLRRIVSFIHQNLLQ................
H2MTU2_ORYLA/354-453                   .....................LGEELRLLKMWGAmRLHILS.LTCTDTRVHLVFSSLKAFLKFKVAFSVS.VAGPvYHLK.V.E.SFQSLIGETSIQQIQDVVASFTPSRNLLTKICRKIHQTLL-c...............
A0A2K5N0S8_CERAT/2200-2297             .....................LGEEIEYLKRWGP.NYNLMN.IDVNNTELRLLFSSSAAFAKFEITLSLS.AYYP.SVPL.P.S.TIQNHVGNTSQDDIAAILSKVPLENNYLKNVVKQIYQDLFQ................
A0A1U7UL77_TARSY/2198-2295             .....................LGEEIEFLKRWGP.NYNLMN.IDISNTKLRLLFSSSAAFAKFQITLSLS.AHYP.SIPL.P.F.TIQNHIGNIGQDEIASILSKVPLENNYLKNVVKQIYEDLFQ................
A0A094LVR5_9AVES/375-472               .....................LGEEIEFLERWGG.KFNLLK.MDIDDTKVKLLFSSSTAFAKFELTLSLA.ANYP.SVSL.P.F.TVQNRIGNIGEEEISAVLANVPTGNHYLRRIVSLIHQNLLQ................
A0A2K5IY49_COLAP/2158-2198             ..............ryklgtl-------------.------.----------------------------.----.----.-.-.-------NNSQDDVAAILSKVPLENNYLKNVVKQIYQDLFQ................
A0A1L1RJ22_CHICK/242-339               .....................LGEEIEFLERWGG.KYNLLK.TDIIDTNVKLLFSTSTAFAKFELTLSLS.SNYP.SASL.P.F.TVEKKIGNIGHEEISAVLSKVPIGYHYLRRMVSLIHQNLLQ................
E2RC04_CANLF/2171-2268                 .....................LGEEIEFLKRWGP.NYNLMN.IDVTNTELRLLFSSSAAFAKFEITLPLS.VHFP.TVPL.P.F.SIQKHLGNIGQDEITAILSKVPLKNNYLKNVVKQIYQDLLQ................
A0A093QPZ2_PYGAD/357-454               .....................LGEEIEFLERWGG.KFNLLK.TDINDTKVKLLFSASTAFAKFELTLSLS.ANYP.SASL.P.F.TVQNQIGNIGEEEISAVLSNVPIGYHYLRRIVSLIHQNLLQ................
G3TPM1_LOXAF/234-331                   .....................LGEEIEFLKRWGP.NYNLMN.IDVNNTELKLLFSSSAAFAKFEITLCLS.AHYP.SVRL.P.F.SIQNHLGNIGQDEIAAILSNVPLEDNYLKNVVKQIYRDLLQ................
A0A093IGA4_DRYPU/368-465               .....................LGDEVEFLERWGG.KFKLLK.TDISDTNLTLVFSSAAAFAKFQLTLSLS.ASYP.NAPL.P.F.TVQKLIGNVGEEEVSAVLSTVPVGLNYLRRIVSSLHQDLLQ................
A0A087VRM1_BALRE/362-459               .....................LGEEIEFLERWGG.KFNLLK.TDISDTKVKLLFSASTAFAKFELALSLS.ANYP.SASL.P.F.TVQNQIGNIGEEEISAVLSNVPVGYHYLRRIVSLIHQNLLQ................
W5QG94_SHEEP/2246-2343                 .....................LGEEIEFLKRWGP.NYNLIS.IDVNNTELKLLFSSSAAFAKFEITLSLS.AHYP.SVPL.P.F.SIQNHLGNIGQDEVTAILSKVPLEDNYLKNVVKQIYRDLLQ................
A0A1S3HL39_LINUN/853-948               ............arilsaeve-------------.RIQLTHvVKVAETSVTIEFSHLDAFCKFVLTFHLKpGEYP.YTPV.E.W.NFKHCIGDIRQEEVSQIIGNQKLGIGYLSRAVDAL------dkfldq..........
G1TA60_RABIT/2173-2270                 .....................LGEEIEFLKRWGT.NYNLMN.IDVKNTELTLLFASSAAFAKFEITLSLS.AHYP.SVPL.P.F.MIQNHIGNTGQDEIATILSKVSLEDNYLKNVVKQIYQDLFQ................
C3Z3N5_BRAFL/1614-1701                 .............sivlrhpf-------------.------.TTVDGTDLTVEFSSVEAHAKFFVTFSLTpGAYP.NQVV.K.C.TCTHRIGAISPSAVEGALCGVPAGSLYLTRMVQSVE-----eliqq...........
U3JEG9_FICAL/52-149                    .....................LGEELEFLQRWGA.KFHLLE.TDIKGTKVKLLFSSSVAFAKFELTLALS.HDYP.SAVL.P.F.GVQTHIGNIGEKEVAAVLSRVPAGHHYLQRIVISIHQNLLQ................
G1PQP6_MYOLU/2073-2170                 .....................LGEEIEFLKRWGP.NYNLMN.IDVNNTELRLLFSSSAAFAKFEITLSLS.AHYP.SVLL.P.F.SIKNHLGNISRDEISALLSKVPLEDNYLKNVVKQIYQHLLQ................
A0A093F7A1_GAVST/362-459               .....................LGEEIEFLERWGG.KFNLLK.TDINDTKVKLLFSASTAFAKFELTLSLS.ANYP.SASL.P.F.TVQKQIGNIGEEEISAVLSNVPIGYHYLRRIVSLIHQNLLQ................
A0A2K5IYS6_COLAP/2110-2141             .....................LGEEIEYLKRWGP.NYNLMN.IDVHNTETA-------------------.----.----.-.-.-----------------------------------------mter............
A0A091JIB3_EGRGA/357-454               .....................LGEEIEFLERWGG.KFNLLK.TDISDTKVKLLFSSSTAFAKFELTLSLS.ADYP.SASL.P.F.TVQKQIGNIGEEEISAVLSKVPTGYHYLRRIVSLIHQNLHQ................
A0A226NFI7_COLVI/276-373               .....................LGEEIQFLERWGG.KYNLLK.TDIVDTNVKLLFSSSTASAKFELTVSLS.SSYP.SSSL.P.F.TVENKIGKIGREEISAVLSEVPAGYHYLRRMVSSIHQSLLQ................
H3C760_TETNG/229-328                   .....................LGEELRLLKMWGGlRLDILH.ISCVDTLVHSVFSSLKNFKKFEVVFSVSlSDHH.YVLH.L.H.SFKNMIGDTTLQQVEDIVASVTPGKNLLTKTLKKIYENL--pq..............
G3HYS5_CRIGR/15-112                    .....................LGEEIEFLKRWGP.NYSLMD.INMNNTELRLLFSSSAAFAKFEITFSLS.AHYP.LAPL.P.F.TIQNHFGNTGHDEIAAIISKVPLEDNYLKNVVKQIYQDVLK................
A0A287A512_PIG/199-296                 .....................LGEEIEFLKRWGP.NYNLMN.IEVNNTELRLLFSSSAAFAKFEITLSLS.AHYP.SVPL.S.F.SIQNHLGNIGQDEIAVILSKVPLEDNYLKNVVKEIYRSMLQ................
F6YXN8_XENTR/2154-2251                 .....................LGEEVEYLMKWGA.KYNILK.IQVESTEVKLLFSSSLAYAKFELIINLS.ESYP.TLPL.T.F.TFRNHIGNIGHSNISAVLSKVPVGLWYLKRAVRHIHQHLL-v...............
A0A151MUX0_ALLMI/2061-2158             .....................LGEEIEFLMKWGG.KFNLLK.TEVDDTKVKLLFSTSTAFAKFEVTLSLS.ATYP.SAPL.P.F.TVQKLIGNLSQDEISAVVSSVPLGTNYLRRMVKLIHHKL--fp..............
A0A286Y2U7_CAVPO/2102-2185             .....................LGEEIEFLKRWGP.NYNLMD.IYVNNTELRLLFSSSVAFAKFEITLSLS.ANYP.LVPL.P.F.TIQNHLGNTGQDEIASIISKVPLED----------------ti..............
A0A096NTH1_PAPAN/2249-2300             .............ayyadcti-------------.------.----------------------------.----.---T.V.P.TIQNHVGNTSQDDIAAILSKVPLENNYLKNVVKQIYQDLFQ................
A0A091FVY8_9AVES/371-468               .....................LGEEIEFLERWGG.KFNLLK.TDIDDTKVKLLFSSSTVFAKFEVTLSLS.ASYP.SASL.P.F.AVQKRIGNIGEEEVSAVLADVPTGHHYLRRIVSSIHQTLLQ................
A0A091RIQ9_9GRUI/280-377               .....................LGEEIEFLERWGG.KFNLLK.TDINDTKVKLLFSSSTAFAKFELTLSLS.ANYP.CASL.P.F.TVQKQIGNIGEEEISAVLSTVPVGYHYLRRIVSLIHENLLR................
#=GC SS_cons                           .....................HHHHHHHHHHHGG.GGTEEE.EEEETTEEEEEEEETTTTEEEEEEEE--.TTTT.SS--.-.E.EEEEEES---HHHHHHHHTTS-SSTTHHHHHHHHHHHHHT-................
#=GC seq_cons                          .....................LGEEIEaLcRWGs.paNLhc.h-lssTcl+LLFSSSsAFAKFElTLuLS.upYP.sssL.P.a.olQspIGNhup--IuulLSpVPlsppYL+plVppIapsLLQ................
//
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