GenomeNet

Database: Pfam
Entry: LIDHydrolase
LinkDB: LIDHydrolase
Original site: LIDHydrolase 
#=GF ID   LIDHydrolase
#=GF AC   PF10230.9
#=GF DE   Lipid-droplet associated hydrolase
#=GF PI   DUF2305;
#=GF AU   KOGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   KOGs (KOG3975)
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.00;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21478430
#=GF RT   The putative Saccharomyces cerevisiae hydrolase Ldh1p is
#=GF RT   localized to lipid droplets.
#=GF RA   Thoms S, Debelyy MO, Connerth M, Daum G, Erdmann R;
#=GF RL   Eukaryot Cell. 2011;10:770-775.
#=GF RN   [2]
#=GF RM   21478434
#=GF RT   Involvement of the Saccharomyces cerevisiae hydrolase Ldh1p in
#=GF RT   lipid homeostasis.
#=GF RA   Debelyy MO, Thoms S, Connerth M, Daum G, Erdmann R;
#=GF RL   Eukaryot Cell. 2011;10:776-781.
#=GF RN   [3]
#=GF RM   24357060
#=GF RT   Novel lipid droplet-associated serine hydrolase regulates
#=GF RT   macrophage cholesterol  mobilization.
#=GF RA   Goo YH, Son SH, Kreienberg PB, Paul A;
#=GF RL   Arterioscler Thromb Vasc Biol. 2014;34:386-396.
#=GF DR   INTERPRO; IPR019363;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is conserved from plants to humans. The
#=GF CC   function is as a lipid-droplet hydrolase. Human LDAH plays a
#=GF CC   role in cholesterol homeostasis [3].
#=GF SQ   1163
#=GS R7YVP5_CONA1/22-128         AC R7YVP5.1
#=GS A0A2K1XC88_POPTR/65-259     AC A0A2K1XC88.1
#=GS A0A132AAT9_SARSC/1-107      AC A0A132AAT9.1
#=GS A0A0R0KLX5_SOYBN/73-306     AC A0A0R0KLX5.1
#=GS M5C256_THACB/1-117          AC M5C256.1
#=GS A0A0J7NLV7_LASNI/31-290     AC A0A0J7NLV7.1
#=GS S8A0N0_PENO1/20-347         AC S8A0N0.1
#=GS A0A183GS52_HELBK/43-112     AC A0A183GS52.1
#=GS I1NVD9_ORYGL/36-286         AC I1NVD9.1
#=GS A0A1C7MR58_GRIFR/49-295     AC A0A1C7MR58.1
#=GS A0A1B8D5A8_9PEZI/25-245     AC A0A1B8D5A8.1
#=GS A0A1A9XIW2_GLOFF/21-258     AC A0A1A9XIW2.1
#=GS A0A165JWE0_9BASI/44-305     AC A0A165JWE0.1
#=GS A0A2I2YQ53_GORGO/43-163     AC A0A2I2YQ53.1
#=GS A0A0E0FZ33_ORYNI/112-350    AC A0A0E0FZ33.1
#=GS F6HKQ8_VITVI/69-319         AC F6HKQ8.1
#=GS A0A0K9QR94_SPIOL/75-324     AC A0A0K9QR94.1
#=GS A0A096N270_PAPAN/43-303     AC A0A096N270.1
#=GS A0A194PQ03_PAPXU/26-276     AC A0A194PQ03.1
#=GS A0A094CDN5_9PEZI/22-313     AC A0A094CDN5.1
#=GS LDAH_RAT/43-303             AC Q5HZX7.1
#=GS A1CAS0_ASPCL/31-336         AC A1CAS0.1
#=GS A8PVH8_MALGO/23-248         AC A8PVH8.1
#=GS X6PED7_RETFI/98-220         AC X6PED7.1
#=GS A0A0K6FYC7_9HOMO/59-129     AC A0A0K6FYC7.1
#=GS A0A1W2P820_MOUSE/38-208     AC A0A1W2P820.1
#=GS M7BD41_CHEMY/2-69           AC M7BD41.1
#=GS A0A0N0NJR9_9EURO/28-386     AC A0A0N0NJR9.1
#=GS T0R8J3_9STRA/69-311         AC T0R8J3.1
#=GS A0A1V8U7D7_9PEZI/1-166      AC A0A1V8U7D7.1
#=GS A0A2I4HKE7_9ROSI/68-317     AC A0A2I4HKE7.1
#=GS A0A1I8C8F0_9BILA/5-268      AC A0A1I8C8F0.1
#=GS A0A1B9G291_9TREE/45-308     AC A0A1B9G291.1
#=GS A0A177UC20_9BASI/36-330     AC A0A177UC20.1
#=GS G3QDB2_GORGO/43-303         AC G3QDB2.1
#=GS G2QWW9_THITE/32-338         AC G2QWW9.1
#=GS A0A179FL24_METCM/17-304     AC A0A179FL24.1
#=GS H6C7Y4_EXODN/174-506        AC H6C7Y4.1
#=GS A0A058Z3J9_9EUKA/88-387     AC A0A058Z3J9.1
#=GS A0A179HT22_9HYPO/16-333     AC A0A179HT22.1
#=GS LDAH_DROME/28-286           AC Q9W0H3.1
#=GS A0A1S3XID5_TOBAC/64-314     AC A0A1S3XID5.1
#=GS M7UCE7_BOTF1/1-137          AC M7UCE7.1
#=GS A0A1I7X4D5_HETBA/6-76       AC A0A1I7X4D5.1
#=GS A0A1D1VXU7_RAMVA/53-193     AC A0A1D1VXU7.1
#=GS A0A0F8C2B2_LARCR/75-334     AC A0A0F8C2B2.1
#=GS A0A059JEA1_9EURO/37-357     AC A0A059JEA1.1
#=GS A0A1S4ACQ7_TOBAC/65-123     AC A0A1S4ACQ7.1
#=GS A0A231MI89_9EURO/32-329     AC A0A231MI89.1
#=GS A0A0U1M4P0_TALIS/21-312     AC A0A0U1M4P0.1
#=GS A0A084QYZ2_STAC4/17-297     AC A0A084QYZ2.1
#=GS C9SZ41_VERA1/3-294          AC C9SZ41.1
#=GS J9AR12_WUCBA/1-202          AC J9AR12.1
#=GS F6UPQ7_CALJA/43-231         AC F6UPQ7.1
#=GS B3M524_DROAN/28-286         AC B3M524.1
#=GS A0A093QT25_9PASS/43-302     AC A0A093QT25.1
#=GS G3HDI7_CRIGR/43-261         AC G3HDI7.1
#=GS E9E6T1_METAQ/17-311         AC E9E6T1.1
#=GS A0A164X9S1_9HOMO/54-305     AC A0A164X9S1.1
#=GS S7QM02_GLOTA/39-296         AC S7QM02.1
#=GS A0A182EKQ6_ONCOC/33-181     AC A0A182EKQ6.1
#=GS E1BNE1_BOVIN/43-303         AC E1BNE1.2
#=GS A0A1S3A6J4_ERIEU/1-173      AC A0A1S3A6J4.1
#=GS K1XE50_MARBU/22-316         AC K1XE50.1
#=GS G1TA86_RABIT/111-371        AC G1TA86.2
#=GS J8PXW7_SACAR/28-292         AC J8PXW7.1
#=GS A0A168MVP5_ABSGL/37-289     AC A0A168MVP5.1
#=GS A0A165C8W5_9APHY/52-304     AC A0A165C8W5.1
#=GS A0A164ZIN3_9PEZI/156-367    AC A0A164ZIN3.1
#=GS A0A0C3FVM9_9HOMO/49-301     AC A0A0C3FVM9.1
#=GS A0A232FEH3_9HYME/527-786    AC A0A232FEH3.1
#=GS W9SE53_9ROSA/105-184        AC W9SE53.1
#=GS A0A1L9WGH2_ASPAC/30-364     AC A0A1L9WGH2.1
#=GS A0A1E4S3X5_CYBJA/4-257      AC A0A1E4S3X5.1
#=GS A0A1Q3CIT0_CEPFO/1-38       AC A0A1Q3CIT0.1
#=GS A0A158PMB7_ANGCS/39-207     AC A0A158PMB7.1
#=GS B9SVY8_RICCO/36-286         AC B9SVY8.1
#=GS A0A0N1IHB2_PAPMA/26-276     AC A0A0N1IHB2.1
#=GS A0A178ZNX8_9EURO/186-534    AC A0A178ZNX8.1
#=GS E7QAL8_YEASB/28-292         AC E7QAL8.1
#=GS C6T7M0_SOYBN/73-323         AC C6T7M0.1
#=GS A0A0R3PWH3_ANGCS/47-186     AC A0A0R3PWH3.1
#=GS A0A182M580_9DIPT/65-324     AC A0A182M580.1
#=GS G3Y795_ASPNA/31-345         AC G3Y795.1
#=GS A0A287MNZ4_HORVV/1-134      AC A0A287MNZ4.1
#=GS G0VH64_NAUCC/26-301         AC G0VH64.1
#=GS W5L1C7_ASTMX/21-279         AC W5L1C7.1
#=GS C5LPW8_PERM5/75-178         AC C5LPW8.1
#=GS A0A1I7THN1_9PELO/41-309     AC A0A1I7THN1.1
#=GS A0A2B7YWY5_9EURO/28-409     AC A0A2B7YWY5.1
#=GS A0A100IMV6_ASPNG/32-350     AC A0A100IMV6.1
#=GS A0A182XF88_ANOQN/65-324     AC A0A182XF88.1
#=GS A0A287MNX7_HORVV/65-243     AC A0A287MNX7.1
#=GS K2SH48_MACPH/45-283         AC K2SH48.1
#=GS A0A164ZIN3_9PEZI/24-139     AC A0A164ZIN3.1
#=GS A0A165YT08_DAUCA/73-323     AC A0A165YT08.1
#=GS U3IVU3_ANAPL/56-316         AC U3IVU3.1
#=GS A0A0D2G5G2_9EURO/148-469    AC A0A0D2G5G2.1
#=GS H3GPH0_PHYRM/105-350        AC H3GPH0.1
#=GS A0A178V9X6_ARATH/12-262     AC A0A178V9X6.1
#=GS A0A0M9WAN5_9EURO/20-319     AC A0A0M9WAN5.1
#=GS F6Y7L6_CIOIN/31-199         AC F6Y7L6.2
#=GS A0A091KJR9_9GRUI/1-257      AC A0A091KJR9.1
#=GS C4JN26_UNCRE/24-92          AC C4JN26.1
#=GS A0A044SER8_ONCVO/40-308     AC A0A044SER8.1
#=GS A0A166ANV4_EXIGL/49-293     AC A0A166ANV4.1
#=GS A0A0D9P4P8_METAN/33-323     AC A0A0D9P4P8.1
#=GS A0A165UKW1_9APHY/47-299     AC A0A165UKW1.1
#=GS A0A194W5Z6_9PEZI/19-330     AC A0A194W5Z6.1
#=GS A0A0W8D6N8_PHYNI/108-353    AC A0A0W8D6N8.1
#=GS A0A2B7YBJ5_9EURO/29-357     AC A0A2B7YBJ5.1
#=GS A0A015J590_9GLOM/54-311     AC A0A015J590.1
#=GS A0A1W4WLL3_AGRPL/31-284     AC A0A1W4WLL3.1
#=GS A0A287MNZ0_HORVV/42-292     AC A0A287MNZ0.1
#=GS A0A0D2CNL1_9EURO/63-128     AC A0A0D2CNL1.1
#=GS H3AES7_LATCH/1-149          AC H3AES7.1
#=GS A0A093H569_STRCA/39-298     AC A0A093H569.1
#=GS A0A261CPU7_9PELO/68-335     AC A0A261CPU7.1
#=GS A0A0T6AX84_9SCAR/34-286     AC A0A0T6AX84.1
#=GS A0A154PRM8_9HYME/31-289     AC A0A154PRM8.1
#=GS B4H5L3_DROPE/28-286         AC B4H5L3.1
#=GS A0A1Y2H6M5_9FUNG/77-331     AC A0A1Y2H6M5.1
#=GS A0A072U3A1_MEDTR/37-287     AC A0A072U3A1.1
#=GS A0A0R3RDP0_9BILA/2-203      AC A0A0R3RDP0.1
#=GS A0A182U2Z8_9DIPT/29-288     AC A0A182U2Z8.1
#=GS A0A1S4ACQ7_TOBAC/171-406    AC A0A1S4ACQ7.1
#=GS D2UX50_NAEGR/116-421        AC D2UX50.1
#=GS A0A093NGQ7_PYGAD/43-302     AC A0A093NGQ7.1
#=GS G0SH53_CHATD/38-347         AC G0SH53.1
#=GS B7FRS5_PHATC/115-213        AC B7FRS5.1
#=GS Q57V42_TRYB2/55-305         AC Q57V42.1
#=GS A0A0H2S913_9HOMO/54-306     AC A0A0H2S913.1
#=GS A0A2G2XSJ8_CAPBA/25-214     AC A0A2G2XSJ8.1
#=GS K7HBI6_CAEJA/41-326         AC K7HBI6.1
#=GS A0A0S6XLJ2_9FUNG/22-319     AC A0A0S6XLJ2.1
#=GS Q0UFS1_PHANO/25-334         AC Q0UFS1.1
#=GS A0A0D1CIJ0_USTMA/31-307     AC A0A0D1CIJ0.1
#=GS A0A0C2GDK2_9BILA/43-137     AC A0A0C2GDK2.1
#=GS A0A1Y2BD88_9TREE/53-311     AC A0A1Y2BD88.1
#=GS A0A195AX29_9HYME/27-287     AC A0A195AX29.1
#=GS A0A1J7HXB5_LUPAN/73-323     AC A0A1J7HXB5.1
#=GS A0A0W0FGH7_9AGAR/50-296     AC A0A0W0FGH7.1
#=GS A0A1J1J9S7_9DIPT/56-313     AC A0A1J1J9S7.1
#=GS A0A178E693_9PLEO/24-334     AC A0A178E693.1
#=GS A0A1V6UPM0_9EURO/27-324     AC A0A1V6UPM0.1
#=GS A0A0F8CYW7_CERFI/8-325      AC A0A0F8CYW7.1
#=GS A0A165Y7G6_9HOMO/54-305     AC A0A165Y7G6.1
#=GS B4LG72_DROVI/29-291         AC B4LG72.1
#=GS A0A2C9LDU3_BIOGL/44-127     AC A0A2C9LDU3.1
#=GS Q6C1F7_YARLI/10-290         AC Q6C1F7.1
#=GS A0A1E4RPQ9_9ASCO/24-316     AC A0A1E4RPQ9.1
#=GS A0A0D2CNL1_9EURO/156-477    AC A0A0D2CNL1.1
#=GS A0A1D5QFH1_MACMU/43-164     AC A0A1D5QFH1.1
#=GS A0A0E0N7U8_ORYRU/130-368    AC A0A0E0N7U8.1
#=GS A0A091FKT0_9AVES/1-256      AC A0A091FKT0.1
#=GS A0A081CJB9_PSEA2/34-305     AC A0A081CJB9.1
#=GS A0A2K5IHX1_COLAP/43-162     AC A0A2K5IHX1.1
#=GS A0A0A1N149_9FUNG/34-288     AC A0A0A1N149.1
#=GS A0A182KZQ6_9DIPT/67-326     AC A0A182KZQ6.1
#=GS A0A0N4ZP62_PARTI/1-256      AC A0A0N4ZP62.1
#=GS A0A2I3FV69_NOMLE/43-163     AC A0A2I3FV69.1
#=GS A0A232FEH3_9HYME/792-1047   AC A0A232FEH3.1
#=GS A0A0R3PPR6_ANGCS/42-319     AC A0A0R3PPR6.1
#=GS A0A1S3EXR0_DIPOR/43-303     AC A0A1S3EXR0.1
#=GS E9CU01_COCPS/134-454        AC E9CU01.1
#=GS K2R2H8_MACPH/25-198         AC K2R2H8.1
#=GS R0I299_9BRAS/37-287         AC R0I299.1
#=GS A0A135LM14_PENPA/20-302     AC A0A135LM14.1
#=GS A0A093UUG0_TALMA/19-180     AC A0A093UUG0.1
#=GS A0A1E4T9E2_9ASCO/15-264     AC A0A1E4T9E2.1
#=GS A8Y1R7_CAEBR/20-290         AC A8Y1R7.1
#=GS A0A0M3KCI7_ANISI/120-284    AC A0A0M3KCI7.1
#=GS V2Z273_MONRO/50-296         AC V2Z273.1
#=GS A0A091K7Z1_COLST/43-262     AC A0A091K7Z1.1
#=GS A4S8S1_OSTLU/88-341         AC A4S8S1.1
#=GS A0A2I2YKB9_GORGO/43-100     AC A0A2I2YKB9.1
#=GS A0A195EHC6_9HYME/31-291     AC A0A195EHC6.1
#=GS A0A1R1PYI6_ZANCU/1-76       AC A0A1R1PYI6.1
#=GS A0A1Q9EPD6_SYMMI/208-474    AC A0A1Q9EPD6.1
#=GS A0A0D2VQH0_CAPO3/161-424    AC A0A0D2VQH0.1
#=GS A0A067FT73_CITSI/36-229     AC A0A067FT73.1
#=GS A0A136J5W9_9PEZI/63-433     AC A0A136J5W9.1
#=GS A0A1G4ISV4_9SACH/29-291     AC A0A1G4ISV4.1
#=GS A0A091N7C4_9PASS/1-150      AC A0A091N7C4.1
#=GS A0A0M8MW91_9HYPO/23-323     AC A0A0M8MW91.1
#=GS A0A2K1XC64_POPTR/65-314     AC A0A2K1XC64.1
#=GS W2KU21_PHYPR/140-375        AC W2KU21.1
#=GS Q6BXR7_DEBHA/26-314         AC Q6BXR7.1
#=GS A0A1J9RT03_9PEZI/194-457    AC A0A1J9RT03.1
#=GS A0A2D3VKY7_9PEZI/22-326     AC A0A2D3VKY7.1
#=GS G5A9R9_PHYSP/112-357        AC G5A9R9.1
#=GS A0A0D7AZC1_9AGAR/47-291     AC A0A0D7AZC1.1
#=GS J3PBI1_GAGT3/71-417         AC J3PBI1.1
#=GS A0A1U7YFU7_NICSY/236-298    AC A0A1U7YFU7.1
#=GS C5GXQ5_AJEDR/172-418        AC C5GXQ5.2
#=GS V9EVA4_PHYPR/114-218        AC V9EVA4.1
#=GS A0A0D2C9V5_9EURO/25-111     AC A0A0D2C9V5.1
#=GS A0A0E0FZ31_ORYNI/130-368    AC A0A0E0FZ31.1
#=GS A0A1D5VG28_WHEAT/77-327     AC A0A1D5VG28.1
#=GS W9WXA0_9EURO/180-499        AC W9WXA0.1
#=GS D8UAJ7_VOLCA/33-300         AC D8UAJ7.1
#=GS A0A1Q3CJ78_CEPFO/1-132      AC A0A1Q3CJ78.1
#=GS A0A2B4RF93_STYPI/28-293     AC A0A2B4RF93.1
#=GS A0A0E0JTV6_ORYPU/123-358    AC A0A0E0JTV6.1
#=GS E7QM04_YEASZ/28-292         AC E7QM04.1
#=GS M0T4V6_MUSAM/107-357        AC M0T4V6.1
#=GS F1A0V4_DICPU/31-280         AC F1A0V4.1
#=GS A0A1Y2HA46_9FUNG/64-326     AC A0A1Y2HA46.1
#=GS K0R7D0_THAOC/36-320         AC K0R7D0.1
#=GS Q2U7V0_ASPOR/1-290          AC Q2U7V0.1
#=GS A0A287MNX2_HORVV/2-209      AC A0A287MNX2.1
#=GS A0A1B8GI87_9PEZI/23-314     AC A0A1B8GI87.1
#=GS H0H2J8_SACCK/28-292         AC H0H2J8.1
#=GS A0A1W2P7C8_MOUSE/43-272     AC A0A1W2P7C8.1
#=GS Q0UDR2_PHANO/26-311         AC Q0UDR2.1
#=GS A0A146FXG6_9EURO/32-354     AC A0A146FXG6.1
#=GS A0A094C199_9PEZI/83-240     AC A0A094C199.1
#=GS A0A1L7WP28_9HELO/27-316     AC A0A1L7WP28.1
#=GS A0A1L0D7H9_9ASCO/25-317     AC A0A1L0D7H9.1
#=GS A0A1D6G442_MAIZE/63-313     AC A0A1D6G442.1
#=GS A0A0U5FM96_9EURO/92-417     AC A0A0U5FM96.1
#=GS A0A0N1IJP9_LEPSE/49-298     AC A0A0N1IJP9.1
#=GS A0A1S8W4I9_9FUNG/90-322     AC A0A1S8W4I9.1
#=GS A0A078J2V0_BRANA/37-287     AC A0A078J2V0.1
#=GS F7C8N0_HORSE/43-303         AC F7C8N0.1
#=GS A0A090KWP3_STRRB/1-151      AC A0A090KWP3.1
#=GS A0A1X2I6Z7_9FUNG/38-293     AC A0A1X2I6Z7.1
#=GS V4T1F8_9ROSI/89-354         AC V4T1F8.1
#=GS A0A0D9YK91_9ORYZ/182-257    AC A0A0D9YK91.1
#=GS A0A0D7A619_9AGAR/44-288     AC A0A0D7A619.1
#=GS W2PZF1_PHYPN/684-929        AC W2PZF1.1
#=GS A0A182RT16_ANOFN/65-324     AC A0A182RT16.1
#=GS B0CR66_LACBS/33-279         AC B0CR66.1
#=GS A0A1L8GBN2_XENLA/94-351     AC A0A1L8GBN2.1
#=GS A0A287MNY4_HORVV/1-134      AC A0A287MNY4.1
#=GS A0A0S4IN66_BODSA/43-292     AC A0A0S4IN66.1
#=GS A0A167DXU4_9PEZI/3-296      AC A0A167DXU4.1
#=GS F0XJT6_GROCL/20-335         AC F0XJT6.1
#=GS A0A074ZBR0_9PEZI/20-316     AC A0A074ZBR0.1
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