GenomeNet

Database: Pfam
Entry: LPD22
LinkDB: LPD22
Original site: LPD22 
#=GF ID   LPD22
#=GF AC   PF18834.2
#=GF DE   Large polyvalent protein associated domain 22
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF SE   Iyer LM
#=GF GA   27.00 27.00;
#=GF TC   27.20 30.80;
#=GF NC   26.30 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   28559295
#=GF RT   Polyvalent Proteins, a Pervasive Theme in the Intergenomic
#=GF RT   Biological Conflicts of Bacteriophages and Conjugative Elements.
#=GF RA   Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;
#=GF RL   J Bacteriol. 2017; [Epub ahead of print]
#=GF DR   INTERPRO; IPR040738;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a predicted enzymatic alpha-helical domain with highly
#=GF CC   conserved aspartate residues [1]. The domain is found in
#=GF CC   polyvalent proteins of phage and prophage genes and is often the
#=GF CC   immediate neighbour of a lysozyme gene [1].
#=GF SQ   36
#=GS A0A0Q4JIQ9_9SPHN/26-122  AC A0A0Q4JIQ9.1
#=GS H8FP78_PHAMO/35-133      AC H8FP78.1
#=GS A0A0U1KXI5_9FIRM/19-119  AC A0A0U1KXI5.1
#=GS A0A1B7XA28_9DELT/57-156  AC A0A1B7XA28.1
#=GS A0A1G8AP24_9RHOO/26-123  AC A0A1G8AP24.1
#=GS A0A2S8BAM0_9SPHN/31-127  AC A0A2S8BAM0.1
#=GS A0A1H4HT81_9BURK/50-148  AC A0A1H4HT81.1
#=GS A0A073ITB4_9BACT/38-142  AC A0A073ITB4.1
#=GS A0A2I7RHR9_9VIRU/22-122  AC A0A2I7RHR9.1
#=GS A0A1B7XAY0_9DELT/33-132  AC A0A1B7XAY0.1
#=GS A0A377R1N8_9NEIS/18-112  AC A0A377R1N8.1
#=GS T0H2D0_9SPHN/34-130      AC T0H2D0.1
#=GS K7ZRM7_9CAUD/19-115      AC K7ZRM7.1
#=GS A0A381E9H3_9GAMM/11-106  AC A0A381E9H3.1
#=GS A0A196MP94_9SPHN/33-129  AC A0A196MP94.1
#=GS Q6LJT0_PHOPR/42-141      AC Q6LJT0.1
#=GS N6X718_9ALTE/42-139      AC N6X718.1
#=GS Q775D4_BPBPP/40-139      AC Q775D4.1
#=GS A0A368WH57_9BURK/19-115  AC A0A368WH57.1
#=GS V7FHU5_9RHIZ/19-123      AC V7FHU5.1
#=GS R9B6Z4_9GAMM/9-114       AC R9B6Z4.1
#=GS A0A1B7X8P5_9DELT/31-130  AC A0A1B7X8P5.1
#=GS A0A0A0EVV4_9GAMM/21-116  AC A0A0A0EVV4.1
#=GS A0A1C9VHP3_9BURK/35-132  AC A0A1C9VHP3.1
#=GS C1D7V1_LARHH/17-116      AC C1D7V1.1
#=GS A0A1Y4GNW3_9BACT/41-145  AC A0A1Y4GNW3.1
#=GS A0A0R3Q2Z1_9BILA/1-93    AC A0A0R3Q2Z1.1
#=GS K4NZ44_9CAUD/42-139      AC K4NZ44.1
#=GS A0A0M4CXX7_SPHS1/38-136  AC A0A0M4CXX7.1
#=GS A0A2I7QLB2_9VIRU/22-124  AC A0A2I7QLB2.1
#=GS A0A243PEU0_9SPHN/28-125  AC A0A243PEU0.1
#=GS A0A106BIY4_THIDE/34-130  AC A0A106BIY4.1
#=GS A0A1L8P9Y3_9RHIZ/16-120  AC A0A1L8P9Y3.1
#=GS A0A1N6KP96_9BURK/42-140  AC A0A1N6KP96.1
#=GS B6WT73_9DELT/17-111      AC B6WT73.1
#=GS A0A0B8ZJZ7_9SPHN/48-146  AC A0A0B8ZJZ7.1
A0A0Q4JIQ9_9SPHN/26-122             ......r-DAAISRRI-QDANA....EQAARVSQLARELD.......YPETLVSADL....PAFEARA........KSYRAQGVI..AQYPAIGA..WS.AKGSNADIAAD..DYDK..LGLFGKAFYGLKNVGG--tl..
H8FP78_PHAMO/35-133                 ...arlg----SNLIAAADTNP....DAHAKAMEIGRQIG.......APADAIAANL....GEGERMA........KLQKMREAL..GSAPKLAE..FLtSDPDMAKLSSD..DFSA..LTRLEGSMTAAASFG---rgv.
A0A0U1KXI5_9FIRM/19-119             .....np--LGQVMQVAKNLPQ....DQAAKILKYSLASG.......DAPILVANNL....HAYETDI.......vDQIDWDNVL..QQSPKTYE..FL.NNPLHMAAVRDqqNVAT..LSNLENSWLSWHDLKEG-g...
A0A1B7XA28_9DELT/57-156             .......RSAAPMLEYAVTRNP....DTVADAQKIAKRTG.......MDADFVEQNY....DQLSAQD........RAERQQRLM..ETMDAGGTmyFM.RDPVNAGMAHD..DLEN..LIRIEQESNPFRALGKT-a...
A0A1G8AP24_9RHOO/26-123             kalreqy-------RA-TSITP....DDAAKVIDISARTG.......IPKPVVVRNQ....SEAAKLA........AEPDWDGLQ..VTAPVTVR..ELaANTKLFDLAHD..DTDN..LSELERTMNRRSEGQ---igg.
A0A2S8BAM0_9SPHN/31-127             ...vest-----AISLLNAPPP....DTVADAARLAQRFG.......INAMQVAGNL....EEFKRRQ........RIEDLTSTA..LSISGFGS..WA.QNPQNAAIAAD..DTEN..VGVLGSIWQGIKNVGS--sa..
A0A1H4HT81_9BURK/50-148             ......q-TAQSNIALAVGANP....DYEAEMQRLAQQTG.......TPVDSVKAFP....DVVKQKAt......vNSIDFQNLA..KQFPTTAA..FY.QSQNNAKIAHD..DVGG..LQSVEQATTNLGPA----snv.
A0A073ITB4_9BACT/38-142             ....kle---EVYTKY-AAEDP....EAHARRVWTAEAVG.......VPQWIQERDEm.yaKEAERRLal...ltkGMPDWRGLS..EKYPLTAR..FF.EDEDVMASAND..DVEA..LAAKEGEARRAGAVAKA-l...
A0A2I7RHR9_9VIRU/22-122             ...tqln----ATMSEAVKVNP....DQHAQTVKLSQASG.......VPEFAVQSNP....EQVEHKLk......lDQINLEGMT..TRAPKTSN..FLtSNVNNAVIAQE..DVTAglLEGIEKTFDGLG------gaie
A0A1B7XAY0_9DELT/33-132             .......RSAAPMLEYAVTRNP....DTVADAQKIAKRTG.......MDADFVEQNY....DQLSAQD........RAERQQRLM..ETMDAGGTmyFM.RDPVNAGMAHD..DLEN..LIRIEQESNPFRALGKT-a...
A0A377R1N8_9NEIS/18-112             .rslian------AEAGAGVSP....DEAAKRRQTAQRLG.......VPVQAVNDAP....VSAVLQE........QFDKVWRDT..QGLGTLRG..KM.TQPDFYNLAKD..DTPQ..LGTIGELANSAA------rgf.
T0H2D0_9SPHN/34-130                 ..rddel-----AYRI-KVARP....DEEARARALAEPRG.......LAPSAVASNL....PAFEAEA........RAAKAKNVM..SQYPAIGR..WS.AKPGNAAIAAD..DYDN..LSLFGKAFYGLKNFGKT-l...
K7ZRM7_9CAUD/19-115                 ......r-ARAAGITA-PQVEP....DAMGRAMRLADQRG.......LPPGVVADNL....PEYDQQQ........QLDALGDAA..SASPALAR..WL.GDPNHTALSKD..DTGV..LAGLGRQFNSGLLSAK--et..
A0A381E9H3_9GAMM/11-106             ...aarr----LRLLDALHLNP....DKRAEDRTIGMATG.......TPIGLVDDN-....--TRRQY........RVNQLDAQM..QGLAVLPA..AVrKSETFATLAQD..DLET..LASLEKVTKARQRRA---nai.
A0A196MP94_9SPHN/33-129             ......r-DEEMAFRI-KVAKP....DEAARAGAIAKARG.......LPAAVVESNL....PAFEMEA........RAARAKAAA..QDYPAIGR..WS.AKGNNAAVAAD..DYDN..LSLLGKAFYGLKNVGKT-v...
Q6LJT0_PHOPR/42-141                 .....fq--LSTSMKYGREADP....ERAGRVFRQQLKTG.......LPSELIERNL....DDIEKQS........AEKDFDPVAfrNKSPLLSG..WL.QKPENAKVSHD..DLEN..LSTMEWLFRAPVEAYQD-g...
N6X718_9ALTE/42-139                 .....vl--AR-SVNQAVTEQP....DDLAYIRRLSEDTG.......LSPYIVRENR....DDIERRV........KQREMGAQI..EGFSQPGK.eWL.SRPDNLGVAQD..DLPA..LRALDDAIANRDWYAQD-s...
Q775D4_BPBPP/40-139                 ......q-AARAGFVLASDTDP....DAYAEAQRVARRAN.......LPIETVLNQP....KEAKRQDt......iGAIDFDTLG..KTSPATAA..LL.ADVEKAKIAHD..NVDN..MTGIESVLSSLGTAVKY-l...
A0A368WH57_9BURK/19-115             ..rgvkt-----ALSEAYGTNP....NIEAELQRVSKTTG.......VPLSTARNMP....NEAKRNAy......vNGINAFELA..KNYPIFAR..FI.TNENNARVAHD..DVDN..LTALEKAVREL-------pdef
V7FHU5_9RHIZ/19-123                 ......v-GAAQVVLGSVNEKP....DEIAGDLNLANEFGkatgnpvPPLPMVREYR....NVFQQKI........EEQKNKTIL..SSKPRLTE..WL.RSPDNAALARD..DLQN..LSWFEGFGRGVTNTLS--rs..
R9B6Z4_9GAMM/9-114                  .....lt--IGQLLELNQGKNPtqiaDTEARARKAAKSLG.......LDYSKITQTP....EEIASVAde....vnTQKRINDVV..ASDPVLGK..YA.LDPNQAAISLD..DFGG..LKRVSDSVLLLKPSITE-p...
A0A1B7X8P5_9DELT/31-130             .......RSAAPMLEYAVTRNP....DTVADAQKIAKRTG.......MDADFVEQNY....DQLSAQD........RAERQQRLM..ETMDAGGTmyFM.RDPVNAGMAHD..DLEN..LIRIEQESNPFRALGKT-a...
A0A0A0EVV4_9GAMM/21-116             ......r-AREAAITS-PAIAP....DDMAKAQRLGAAHG.......IGPQAVADDL....KHYDELD........QVDRMERFA..TSTPGASR..WL.-TPERAALVRD..DVDT..LERLGRALPSKGATMRA-t...
A0A1C9VHP3_9BURK/35-132             ......r-AVRGSLTATAQTTP....ERAAQLNYLAQVSG.......MPRAVVETDE....GSAKAVA........QLREIWDAS..ADSPVLRA..KL.ANPQFTELAKD..DVGV..LSQIERGVQATTRYIM--ga..
C1D7V1_LARHH/17-116                 .....dq--LAGSLRDALQVNP....DDYAKTVRLAKAAG.......VEVEAVPLYA....DVAQEAQy......lEGIGFRSLW..KDSPKTAE..FL.SDARNARLAHD..DVAN..LSVLEKLARSAGAGLT--aa..
A0A1Y4GNW3_9BACT/41-145             ...eler-----SYERYVTENP....DEAAARAWNAERVG.......VPLWVQERSDkyanEA----KkrlallekGTPDWKKLA..DASPVTAS..FM.TGDGVMASAHD..DVQG..LADIEDVTHSLSYLR---lny.
A0A0R3Q2Z1_9BILA/1-93               ....msv---------GLGANP....DMEAELRKVARRTG.......VPVDTARAYP....EELKRQAa......mGQMDFDSLA..QQFPRTAG..FL.SGTENAKVAHD..DVEN..MGLIETMINSFQR-----gipa
K4NZ44_9CAUD/42-139                 .....qd--FVHSMETVSNISP....DAYAKATAVSRYSG.......VPAKVLHDNA....DRMNQLL........RGNQYAGIY..TNYRKTAN..AL.RDGNLAAVSQD..DLDQ..LVRIEGAASDTRFNQQ--st..
A0A0M4CXX7_SPHS1/38-136             .......RDRQTRLDLLLSASP....DTVGRATTIAKEIG.......VPPMHVEDRL....AEAEKGR........HVRRFMSVA..ERYPAIGK..WAvTQPRGAAAASD..DWDS..LSLLGKTWRSTREVATG-i...
A0A2I7QLB2_9VIRU/22-124             ...tqln----ATMSEAVKVNP....DQHAQTVKLSQASG.......VPEFAVQSNP....EQVEHKLk......lDQINLEGMT..TRAPKTSN..FLtSNVNNAVIAQE..DVTAglLEGIEKTFDGLGGA----isvg
A0A243PEU0_9SPHN/28-125             ......a-AARRSIIMHNAASP....DAAARANVLSRENG.......LPPTIVEQHL....PAFEIAR........RSERANALM..AKHPAIGR..WS.SDPRNIAAAAD..DYDN..LGKLGAAFASRIARD---krd.
A0A106BIY4_THIDE/34-130             ....avr----AGATLALDSNP....DEIARQKRIAQSLG.......VPLAAVEADP....EFATREQ........RVRSIEQAT..ANSPALRQ..KF.SDADFAKLAAD..NVDN..LSGIEQLLRSAKRGFT--ag..
A0A1L8P9Y3_9RHIZ/16-120             ......v-GAASVVLGSLEEKP....DQVAGDLNLANDFGkvtgnpaPPLPMVKEYR....NVFQQKI........EEQKNKTIL..SKAPVLTE..WL.RNPENAAVARD..DLEG..LSWWETTFKAGGNAMSR-g...
A0A1N6KP96_9BURK/42-140             .....qa--AQGVAVANSEQSA....DAAGRAAGIAKQIG.......APQAAVETDL....PRYEAQA........KAQNNAQIL..SQSPRLAD..WVaNNPDSARVAQD..DFDG..MSQLEGLTSAQSAQA---lta.
B6WT73_9DELT/17-111                 .....ir--AALEVADADGVTA....QRVASARATALQLG.......LPDSVVEADL....QYAQREA........QARRIE---..QNSPFALW..AA.RSKERAALARD..DTDG..LAGVFSTAKAFGEIRQY-e...
A0A0B8ZJZ7_9SPHN/48-146             ....rgr---MLGATLRASPAP....DQAAQANRIARARG.......LPAAVVDPKL....QVLQIAD........QATNFLNMT..RLFPHIGS..WAeANPRDAAAAAD..DTKA..LGMLGHAFSERDLSR---gys.
#=GC seq_cons                       ......p...t.shphssstsP....DphAcstplApptG.......lPhshVcssh....sphcppt........ptpchpslh..pshPthup..ah.sssssAslApD..Dl-s..LutlEpshpuhtthht..s...
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