GenomeNet

Database: Pfam
Entry: LRS4
LinkDB: LRS4
Original site: LRS4 
#=GF ID   LRS4
#=GF AC   PF10422.10
#=GF DE   Monopolin complex subunit LRS4
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Wood V;0000-0001-6330-7526
#=GF SE   Pfam-B_63451 (release 22.0)
#=GF GA   24.20 24.20;
#=GF TC   24.30 24.20;
#=GF NC   24.10 24.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11163190
#=GF RT   Functional genomics identifies monopolin: a kinetochore protein
#=GF RT   required for segregation of homologs during meiosis i. 
#=GF RA   Toth A, Rabitsch KP, Galova M, Schleiffer A, Buonomo SB, Nasmyth
#=GF RA   K; 
#=GF RL   Cell. 2000;103:1155-1168.
#=GF RN   [2]
#=GF RM   17627824
#=GF RT   The kinetochore proteins Pcs1 and Mde4 and heterochromatin are
#=GF RT   required to prevent merotelic orientation. 
#=GF RA   Gregan J, Riedel CG, Pidoux AL, Katou Y, Rumpf C, Schleiffer A,
#=GF RA   Kearsey SE, Shirahige K, Allshire RC, Nasmyth K; 
#=GF RL   Curr Biol. 2007;17:1190-1200.
#=GF RN   [3]
#=GF RM   12689592
#=GF RT   Kinetochore recruitment of two nucleolar proteins is required
#=GF RT   for homolog segregation in meiosis I. 
#=GF RA   Rabitsch KP, Petronczki M, Javerzat JP, Genier S, Chwalla B,
#=GF RA   Schleiffer A, Tanaka TU, Nasmyth K; 
#=GF RL   Dev Cell. 2003;4:535-548.
#=GF DR   INTERPRO; IPR018479;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Monopolin is a protein complex, originally identified in
#=GF CC   Saccharomyces cerevisiae, that is required for the segregation
#=GF CC   of homologous centromeres to opposite poles of a dividing cell
#=GF CC   during meiosis I [1][3]. The orthologous complex in
#=GF CC   Schizosaccharomyces pombe is not required for meiosis I
#=GF CC   chromosome segregation, but is proposed to play a similar
#=GF CC   physiological role in clamping microtubule binding sites [2]. 
#=GF CC   In S .cerevisiae this subunit is called LRS4, and in S. pombe it
#=GF CC   is known as Mde4.
#=GF SQ   31
#=GS J7S4Q8_KAZNA/38-112      AC J7S4Q8.1
#=GS LRS4_YEAST/5-232         AC Q04087.1
#=GS LRS4_YEAST/5-232         DR PDB; 3N7N E; 5-33;
#=GS LRS4_YEAST/5-232         DR PDB; 3N7N F; 5-32;
#=GS G8BSR8_TETPH/5-283       AC G8BSR8.1
#=GS Q6FNM3_CANGA/3-297       AC Q6FNM3.1
#=GS MDE4_SCHPO/1-408         AC O43068.1
#=GS C5DLX8_LACTC/5-95        AC C5DLX8.1
#=GS A0A1G4MG68_LACFM/5-201   AC A0A1G4MG68.1
#=GS Q6CWV4_KLULA/5-219       AC Q6CWV4.1
#=GS C7H0U3_9FIRM/41-246      AC C7H0U3.1
#=GS A0A1G4JU86_9SACH/5-107   AC A0A1G4JU86.1
#=GS S9X9N1_SCHCR/14-399      AC S9X9N1.1
#=GS A7TJ97_VANPO/5-220       AC A7TJ97.1
#=GS A0A1E3P1L0_WICAA/92-327  AC A0A1E3P1L0.1
#=GS J5RU06_SACK1/5-232       AC J5RU06.1
#=GS A0A0H5C0N2_CYBJN/27-359  AC A0A0H5C0N2.1
#=GS H2AZR8_KAZAF/5-105       AC H2AZR8.1
#=GS S6E812_ZYGB2/5-237       AC S6E812.1
#=GS G8ZMA4_TORDC/5-242       AC G8ZMA4.1
#=GS W0TB12_KLUMD/88-167      AC W0TB12.1
#=GS B6JW76_SCHJY/99-407      AC B6JW76.1
#=GS W0TB12_KLUMD/22-102      AC W0TB12.1
#=GS G0WET9_NAUDC/5-281       AC G0WET9.1
#=GS G0VGI4_NAUCC/5-210       AC G0VGI4.1
#=GS A0A1G4KAX5_9SACH/5-204   AC A0A1G4KAX5.1
#=GS A0A1G4KMF0_9SACH/5-113   AC A0A1G4KMF0.1
#=GS Q756D8_ASHGO/5-193       AC Q756D8.2
#=GS A0A0C7NEW9_9SACH/5-109   AC A0A0C7NEW9.1
#=GS A0A120K2I6_9SACH/5-237   AC A0A120K2I6.1
#=GS C5DWA2_ZYGRC/5-206       AC C5DWA2.1
#=GS A0A1X7R5U1_9SACH/5-278   AC A0A1X7R5U1.1
#=GS G8JT14_ERECY/5-262       AC G8JT14.1
J7S4Q8_KAZNA/38-112                 .............................................gra-----------------...........---------------...---..---------------....................----------LQMQRQ.......................VNTLTGQLQ.DMSHEND.........................................VL.RETAKSVRAF.................................................................SESKIAALKRQLEALKA-----------.----------.-----------------.--..---------..--......--------------..-----................................---------........................--------.-.....---...-------...--.-----...................................----------..--------.-----..----------eggagrrtkgvgghahtvath............................................................
LRS4_YEAST/5-232                    ................................................LQLLSNYYKAKLDSERI...........YNEY----------V...QSQ..YEFASLDKLNNNKGD....................--PKKVVDETLFLQRQ.......................IAQLNKQLQ.LSFQENE.........................................KL.LSVQKNQKAL.................................................................YQSKLSSKDAFIDDLKLKLKVEQISVDK.HNKERTPSTG.RDEQQRNSKAAHTSKPT.--..-----IHLL..SP......IVNRDKPNNQTNDR..GGNDP................................DSPTSQRRS........................-RGLRSLL.S.....SGK...NTIFDSI...SK.NLDDE...................................INENAHIRND..TTSSKIAG.KSPSR..-LSALQKSPE.................................................................................
#=GR LRS4_YEAST/5-232         SS    ................................................HHHHHHHHHHHHHHHHH...........HHHH----------H...HHH..HHHXXXXXXXXXXXX....................--XXXXXXXXXXXXXX.......................XXXXXXXXX.XXXXXXX.........................................XX.XXXXXXXXXX.................................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXX.XXXXXXXXXXXXXXXXX.--..-----XXXX..XX......XXXXXXXXXXXXXX..XXXXX................................XXXXXXXXX........................-XXXXXXX.X.....XXX...XXXXXXX...XX.XXXXX...................................XXXXXXXXXX..XXXXXXXX.XXXXX..-XXXXXXXXX.................................................................................
G8BSR8_TETPH/5-283                  ................................................LQLLYNYQMSVIESERF...........YYTHLLEEKEL----...--N..TKNEALIKNNDNTAVlvdd............itgkQQEHSLSKELISLQRQ.......................LTKVSIELQ.TMKLSNE.........................................QL.KEAQKVTKNT.................................................................MNQKLNNSLKTIERLKSELSVNNSSHGD.EDA---SS-V.TPPKIF-----NTFKNN.EI..KQKNNIHLL..SP......VTRKESG-------..---HL................................ESNNKIEKL........................-SGIRNIV.N.....SKK...HTLFDMD...TE.SEADN...................................SLNSIENVLK..INTLK---.-----..----------rnevlanmvlpkdalpessdinssqnilsvdiplikgntveekqvknhhetkkrtltktriqklds...............
Q6FNM3_CANGA/3-297                  ................................................LQVVADYYRCVLENERI...........YYEYQLNRRETVKNS...RSE..DEFSGSERTNALK--....................------TDEQLQLQRQ.......................VNKLTVDLQ.SMAHENE.........................................RL.REFQKTQKQI.................................................................LESKIQQLKKTVDSFK-----NERNSSS.SSHVRTPP--.---RQTRSGAYTQGKDT.DL..SRRGGFHLL..SP......IVGNVNP-------..-----................................----GKEKA........................-GGLKETL.K.....VGR...NTIFDKN...SS.LLDDD...................................DDDDDDEING..TSVKERSR.VTGRKlrSSSSLKDS--knnhieeeeamefttdnsdevglmeglklrdgsakanlqlpsgslspdedtqssneettntrkkrrrltrrriqtmnsdns
MDE4_SCHPO/1-408                    ................................................MSTISTSTDSKLDNLGLsvtsrrnqilfYLSKALNLAHLLRSD...SLQ..KSFLDALKQSATDSEllhkn.........ldeikfLQNEKLNNEKLLEQEQneandyrlkverlehkisdyvqeINSLNSQLQ.IQKSNPEkhedavsqnrl...................rgsldtvsspsKT.HKANKDEKATrlhliianlkk...........................................alkekdaevlnLQSHVSSKESELDRFKIKLETEESNWKV.RLQVLESKLA.TQDRKLRMQKKSTERKS.LLvsPRVSSPKLF..SPsk..qaIMGTRQPNATSGSP..LSVTPflqktsts...............iglsssppqSSPSAQSSQpfsrdky..........phsmtvsPSNARYLK.K.....HLD...DTIPSNV...SD.INHNDhlkipqspsslspski..pirkkrklkdtvsncefTEEDSESSFL..LETIQPTK.STLRR..SISPLKKRND.................................................................................
C5DLX8_LACTC/5-95                   ................................................IQLLANYYESVIECERI...........YYEH-------VNCS...---..-----KVQQEPMQRD....................---SLLVKETISLQRQ.......................IAQLTADCN.QQKRENE.........................................RL.KQVHKTQLAL.................................................................LESKLENARK------------------.----------.-----------------.--..---------..--......--------------..-----................................---------........................--------.-.....---...-------...--.-----...................................----------..--------.-----..----------hsrpk............................................................................
A0A1G4MG68_LACFM/5-201              ...............................................a-QLLSIYYESVIECERL...........YYRH-----------...---..---LEAQKGHANNDS....................-SESLLAKETINLQRQ.......................VAQLTADLN.IQKRETE.........................................RI.KELHKTQRAL.................................................................FESKLENAKKTISKLK------RSG---.--AEIEDDKD.ACAENQQAK--------.--..-----FHLL..SP......INRQTSF-GNGNDA..VAGT-................................--PSGKQHR........................--GLRHAI.T.....NGN...PTLFDED...TT.DLADK...................................TEEAA-----..--------.-----..----------fieslksrdklaeivlptsrlsssgd.......................................................
Q6CWV4_KLULA/5-219                  ................................................LQLVAEYYQSVIKCEKI...........---------------...---..------FRTNAKQND....................LSGLMLTRENISLRNQ.......................VQQLTLDLQ.LKKEELD.........................................NA.KKLHKTQKAL.................................................................LESKLENAKAAVK--------KQTTQSS.ESG-------.-SEEIERVK--------.--..-----FHLL..SP......IQNERSK-------..-----................................----SFEKQ........................PSRLRQVI.D.....RNQ...ATLFD--...--.---DE...................................TDDTANRTDD..VLFLN---.-----..----------slkpnndarykvhettdetsteskkkrrlsnkkieindilgnsdddemnsdhlktrvtkmkg...................
C7H0U3_9FIRM/41-246                 kirrnekniksikrrlaagrrienrykkqsekiadkisvtkgsisdin-----------------...........---------------...---..---------------....................----------------.......................---------.---DDME.........................................KTqKKIKKAQKALndaikkvedqegdlggrlrnmyksgsigfvdvllgsgdisdfilnfdmvqriysgdkdllkqledRENEVKTKKADLDRLKLNLAEQKKDLQA.KKAQLSDQKA.EADKKKTSQAKLNKKFGeDLeaMRRDSERLA..--......--------------..-----................................---------........................--------.-.....---...-------...--.-----...................................----------..--------.-----..----------silnpps..........................................................................
A0A1G4JU86_9SACH/5-107              ................................................LQLLAQYYEAVIESDRI...........YHEH-----------...ISS..NLTTGADVNDEAQQ-....................--DSILMKETISLQRQ.......................VTQLIAECN.LLKQENE.........................................KH.KQLHKTQIAL.................................................................MESKLENAKKRA----------------.----------.-----------------.--..---------..--......--------------..-----................................---------........................--------.-.....---...-------...--.-----...................................----------..--------.-----..----------tkpkstspkdg......................................................................
S9X9N1_SCHCR/14-399                 ...............................lhqaenrllqcqlelnf-----------------...........YLTKASNVIHGLQSH...ILR..TTCLEATNHANKLLLqlneggqkseendrraskleEVNGSLTSDIVQLKSK.......................ISSLEANIS.QNLEDMS.........................................KL.HKLNLENSGQeelplmnadsehaeskasymspdktnlss.......snaeqvarlhrtitelkksykekdsdlnkLHSALSAKESELNRWKIKLETEESNWKV.RLQVLESKVA.TQGKKLRKNEVKRSKST.LI.tPGLTSSNTK..SP......LSPALRS-PPKKSP..LRVTPylqrts....................aivglpSSPSQASPTirsgi.............ttttqtPNKDSSLIgS.....ARK...ETDHNNI...DS.GNAEEnpassrrlssltpskiplptrkkrkfetdnttkfeELDESDTSMT..MEVPLQTK.VTLPR..TISPPKARS-e................................................................................
A7TJ97_VANPO/5-220                  ................................................LQLLANYYKSVIEGERI...........YYEN-----VIGKEE...RQQ..SSNDGSTLTKSSGSD....................---------TLMLQRQ.......................ITQLNTDLQ.VLRHENE.........................................QL.KEMQKTHRAL.................................................................MESKLKSSKKIIENLKNDLRNNNNTDDQ.NNGEQNT---.IDINKEELQ--HSSRIS.TM.vSKKIGFQLL..SP......MNERLLR--GTG--..-----................................--RNTDKNQ........................LSGLRYVI.S.....TGK...HTIFD--...ES.YQDDT...................................DNSKDDGVDG..VLLANP--.-----..----------vknveklanlvlpsd..................................................................
A0A1E3P1L0_WICAA/92-327             ...............................................k-----------------...........---------------...---..-------KKSANQT-....................----SLQKETLSLKNQ.......................ITKLNSQLN.ESRNEIG.........................................KV.KQQFVTQKAV.................................................................LESKLENAKKNIKNLK------DKNTLS.PSKALQPPSSiLSPVKSQSKTLNNHQKL.GLkrPLVSNFS-T..SP......FLNKNLHKATSPSK..DGKQQn.............................nfQSPVPLNSQnllatstpgapnavsplkdlksrkPSGLKNLI.SpakppSNG...ATKPNSK...KKpSLFDD...................................DDDDDEDIFGnsIRKLDATK.NTPRQ..----------eppseeskqdne.....................................................................
J5RU06_SACK1/5-232                  ................................................LQLLSNYYKAKLDSERI...........YNEY----------I...QSQ..YEFASLEKLNNNKSP....................--SKKVVDETLFLQRQ.......................IAQLNKQLQ.ISFQENE.........................................KQ.QNIQKNQRAL.................................................................YQSKLSSKDAFIDDLKLKLKVGQISIDK.ADMETAPSTA.SNEQLNGVKEAHISRPT.--..-----IHLL..SP......IVNRDTSKNQTKDR..NGNEP................................DSPITKRKS........................-KGLRSLL.S.....SGK...NTIFDSI...SK.NLDDE...................................INENASMRHD..TASSKIAD.KSTSV..--SPL-----lrkppe...........................................................................
A0A0H5C0N2_CYBJN/27-359             ..rrsliheatllktileqqmyvemnnskdshvqsslkqdlskvqgek-----------------...........------------RSL...DRK..ISLLQTEIQNLKERA....................LSNAQLQRENISLKNQ.......................VKKLTSQLD.ESKSEIG.........................................KA.SKQFATQRAV.................................................................LESKLDNAKKNIKTLK----DRTSPVKPlTGSILSPQKT.SSNERINVLK-----K-.--..PHLNSNFSV..SP......FLRNRQS---KQDL..GSSTPvqdnrnniktkifaqstpngnvfasplkdakpR-------Rssgl...............knlvrP--TNSLK.A.....ALD...NPDKKNK...PS.LFDDD...................................DEDDDGDIFG..NSVLKKAE.KK---..----------dhdddttekktqpdikkkkrkigsttiveeteidedeksiplkrvklidklggmsplkqrnk...................
H2AZR8_KAZAF/5-105                  ...............................................v-QLISNYYKSVEKAEKI...........YNHY-----------...---..--IAREPNLSTTS-S....................--APKIVNETLLLQKQ.......................LSDLTSQVQ.NLKREND.........................................NL.KESIKLYKAL.................................................................NESKISNYKKIIDNLQ------------.----------.-----------------.--..---------..--......--------------..-----................................---------........................--------.-.....---...-------...--.-----...................................----------..--------.-----..----------ndntvkdnkd.......................................................................
S6E812_ZYGB2/5-237                  ................................................LQLLANYYNSVLESERI...........YHEN-----------...---..VACSSSVPCPSLQRE....................-PSPKVEQEMLLLQRQ.......................VHQLTSEVQ.VLHREND.........................................TL.KELQKTQRAL.................................................................MESKVNNSKKTIE--KLRKQLNEPDRKE.SNNATPPP--.-----TQLK--------.--..-K-RELHLL..SP......LTGRKLE------G..VGVSQ................................ISKNSNGSM........................--GLRRAL.S.....SGQ...HTLFDD-...--.--HDIgnqtldhiadinfids...iknrekllqielptnaL---------..--------.-----..----------sdneeaqrkpstkigkkrrlarkpiqklnndsd................................................
G8ZMA4_TORDC/5-242                  ................................................LQLLANYYKNVIESQRI...........YHEN-----------...-VQ..I-YASPLEESGSTGS....................GSSSRVAEEMFLLQRQ.......................VSHLTAEIQ.SLSREND.........................................KL.RGLQATHKAL.................................................................MESKLNNSKKIID----KLKREQRDYRA.APD-RESDST.PPPPELSKK-------G.--..--QAPFHLL..SP......LNVRKID-------..-GAKH................................DHITAASSK........................PTGLRQVL.T.....GGH...QTLFDGD...QT.IENLSadrtd.........................dvlfiN---------..--------.-----..----------sikhkdklgsvvlptealsededsqvkatskptlavtngkgvtkkrkl.................................
W0TB12_KLUMD/88-167                 .....................................klsseagseet-----------------...........---------------...---..---------------....................----------------.......................---------.-------.........................................--.----------.................................................................----------------------------.----------.-----------------.--..-ERVKFHLL..SP......IQNERTK-------..-----................................----SFERE........................PSRLRQVL.D.....RGH...MTLFD--...--.---DE...................................TDDTANRTDD..VLFLN---.-----..----------slrpntdarfrsq....................................................................
B6JW76_SCHJY/99-407                 .....................................denenklgsae-----------------...........---------------...---..---------------....................-------KELVQLKEE.......................YKQLQEDLIkLSKKTYEseetirllksskesgesatfgknvessssttrlhnavneykKL.LKAKEQDITK.................................................................LQSSVSARDTEIDRWRIRVETIEANWKA.RVQVLESKLA.TLEKKTRLSRSAHDRKS.TS.sTMLSSPQLVtnSPspqkssLSSRRSI--REKSS..LSMTPflkktsvalglss......splrrdaktlpkpL-------Spnksfsetr......srlprpslsP-----SK.R.....TST...NVDGDSI...SQ.NLVQEalgngslkkkrk...........leapslevqpvdEENELHSDED..LTLAPPKRaSSIVR..AISPLKARSE.................................................................................
W0TB12_KLUMD/22-102                 .............................................fnn-----------------...........---------------...---..---------NVRQND....................LSDLVLARENISLRNK.......................VQQLSLDLQ.LKQEELD.........................................SA.KKLHKTQKAL.................................................................LESKLENTKSNLKK----LSSE------.----------.-----------------.--..---------..--......--------------..-----................................---------........................--------.-.....---...-------...--.-----...................................----------..--------.-----..----------agseetervk.......................................................................
G0WET9_NAUDC/5-281                  ................................................LQLMANYYKAVIANEKI...........YYDY-LIQEHEHDKN...QSE..QSISAPLSSSSFAPPttgt............ittaSTTPRMIDETLLLQKQ.......................LTTLTAQLQ.ELTKEND.........................................HL.KELQKSTKSL.................................................................METKLNSYKKRLS--K--TAFNNNNNSS.SSNNSNNS--.---LKLDTTSGKNDND-.--..---TGFHLL..SP......INTNRNKSKLPGKKslLHNNY................................NSTSIKGKAekdkneg.........vfddepsnRTSLREVL.S.....SGK...HTLFD--...--.--DDD...................................EEGEKDGSED..VNVDTS--.-----..----------ekndrgkastadstsdvlflqsfndksksvsqsiskptsnpd.......................................
G0VGI4_NAUCC/5-210                  ................................................LQLLSTYYKSVIESERI...........YNEYQL--SANVQHI...PNN..KNGSSSSTSISTDS-....................----RIVDETLLLQKQ.......................LTQLTSQLQ.KLTQENE.........................................TL.KEVQKSNKAL.................................................................AETKIQNYKKRIN-----ILVQRENGKN.TEK-------.-DEDQ--------KKPV.--..-----LHLF..SP......LRKRGLD-------..----E................................TKGRIKNKN........................GSGLRDVI.S.....TGK...HTLFDDD...ED.EDEND...................................DDTSPNRSED..VLFLQS--.-----..----------lnpsskgknnkrrklklsrk.............................................................
A0A1G4KAX5_9SACH/5-204              ................................................LQLLAKYYDSVIKSEQI...........YSDY-------IRTT...ESG..SSV--------KDAD....................---SMFIKETISLKHQ.......................LAQLITDLN.QEKRENE.........................................RL.RELHKTQIAF.................................................................LESKLDSAKRNISKLK--DQNPDTNGDD.NND----KNS.KA-LKRTSG-KSNETSA.--..-LANKFHLL..SP......INRGSTR---SEAM..DETDP................................----LPKKA........................PSGLRQAI.Y.....NRH...QTLFD--...--.---DD...................................TNDGADKTDE..FSFMNSIK.H----..----------rgklaelq.........................................................................
A0A1G4KMF0_9SACH/5-113              ................................................LQLLTNYYEAVIESDRI...........YHEN-------VNG-...---..----GRLKFDSGDVV....................QKDSMLVKETISLRRQ.......................IAQLATECN.LLKQENE.........................................KH.KQLHKTQLAL.................................................................LESKLENARKL-----------------.----------.-----------------.--..---------..--......--------------..-----................................---------........................--------.-.....---...-------...--.-----...................................----------..--------.-----..----------apkpkcttpdngeehrkev..............................................................
Q756D8_ASHGO/5-193                  ................................................LQLLADYYESVIRCEEI...........YIEF-----------...---..ISGLGPNKTKSGQQS....................--GSVATEETISLKKQ.......................IEQLVSDSV.KQRQEIE.........................................KL.RELNKTQRAV.................................................................LESKLETAKKQVA--------RATGSAN.AGGARADDGG.AAQEEGGAG--------.--..-----FHLL..SP......LRRGGRR-------..-----................................ASGGGAGAR........................-AGLRLAL.D.....AGN...ETIF---...--.---DG...................................ADEDTEAVLG..VEAVAGAG.VRARE..VGRALRCTGE.................................................................................
A0A0C7NEW9_9SACH/5-109              ................................................LQLLANYYEAVLESERI...........YNEH-----------...SHD..DHP---LTKRSVDPE....................NRDSMLVKETISLQRQ.......................VAQSIHECN.VLKQENE.........................................RQ.RQIHKTQIAL.................................................................LESKLDNARKNSA---------------.----------.-----------------.--..---------..--......--------------..-----................................---------........................--------.-.....---...-------...--.-----...................................----------..--------.-----..----------kskegalaetvn.....................................................................
A0A120K2I6_9SACH/5-237              ................................................LQVLANYYESVIQCEQI...........YSDH-----------...---..IIALQLRDPEAKEQH....................--ELMLTKEAISLKKQ.......................MEELVTENV.IQQQEIE.........................................KL.REVNKTQRSV.................................................................LESKLETAKKQLAKYK-----EQKNGIQ.NYQ-------.---ENSNSPGKSKGRQS.--..-RFSRFHLL..SP......MQRLKSG-------..-ERRP................................NKIAINNRV........................-AQLRQLI.N.....EGQ...KTIFDDT...SD.DSMNRsdemvfieslkqr........smkakdsskdikefDDEGEARESD..ISTQKKKR.KLSRK..RIE-------tvftdne..........................................................................
C5DWA2_ZYGRC/5-206                  ................................................LQLLVNYYESVVTSERI...........YFQH-VNRGSLNRQNgngSGN..GSGSGSGSGSGSN--....................-NSNGSEREMLLLQRQ.......................VHQLTSELQ.RQSHEND.........................................TL.KELQKAQRAL.................................................................MESKLNNCKKTIERLK-----KQHNGKN.MNGDAIEEGG.QGQLKKREQ--------.--..------HLL..SP......LVGRKLE-------..-----................................----GVGKT........................-KGLRRAL.T.....SGQ...QTLFD--...DE.NDDDD...................................REGTVDRIND..VNFVG---.-----..----------sirraggnggrl.....................................................................
A0A1X7R5U1_9SACH/5-278              ................................................LQLLLDYYRSVLESDRI...........YHEGILKYQQQSNGD...NVTgaLNGEEVDKDDASKSV....................SVAPKIANETLLLQRQ.......................LTDLTSQLQ.DLKRKNE.........................................AL.QEQQKSYRAL.................................................................NESKIAKFKRTIDSLKRKNERHSSEID-.------DH--.-DDQINEDD----SKKF.--..----DYHLL..SP......VAKRGLK---RGLK..ISNGKgkgrkgtifdskk......etftddessensiDSPTVKRLTkqprmehee......sflksfepqPSNNSNKK.K.....NKQldgFDIPSLN...DF.SRDED...................................EDEDQDESHG..NNEDLTTK.NYHHK..KQKPLKKR--k................................................................................
G8JT14_ERECY/5-262                  ................................................LQTLANYYESVIQCERI...........YSDY----------I...IAQ..QSIDP--KTKQQH--....................--ESILTKETISLKKQ.......................VEQLITESV.SQRQEID.........................................RL.RNLNKTQRSL.................................................................LESKLEAAKKRLARSKEGVVNQDEQVLQ.KQEDLNGRGG.NEATGGGSGSGSDGSAS.--..NNGAGFHLL..SP......LRSPGGK-------..VKARK................................LNGIAVHNR........................VARLRQVI.N.....EGR...KTMFDEDtddSA.NLTDEvmfmetfkrtdaagns..sagdgqgntagnevhpeDEDDDENMEG..--------.-----..----------egssqlkkrklsrkriqtten............................................................
#=GC SS_cons                        ................................................HHHHHHHHHHHHHHHHH...........HHHH----------H...HHH..HHHXXXXXXXXXXXX....................--XXXXXXXXXXXXXX.......................XXXXXXXXX.XXXXXXX.........................................XX.XXXXXXXXXX.................................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXX.XXXXXXXXXXXXXXXXX.--..-----XXXX..XX......XXXXXXXXXXXXXX..XXXXX................................XXXXXXXXX........................-XXXXXXX.X.....XXX...XXXXXXX...XX.XXXXX...................................XXXXXXXXXX..XXXXXXXX.XXXXX..-XXXXXXXXX.................................................................................
#=GC seq_cons                       ................................................LQLlusYYcuVlcs-+I...........Y.ch.......................t..ptpsppt.......................t.hlscEsl.Lp+Q.......................lspLssplp...ppEs-.........................................+L.+clpKoQ+AL.................................................................hESKLpstKKplpp.K.....ppps.t..t.t..............t.t...................+Ll..SP......l.ttt......................................................ttt.........................tth+phl.p.....ttp...tThhs...........sp...................................pppt.t...t............................p.p.ttt..........................................................................
//
DBGET integrated database retrieval system