#=GF ID LSM14
#=GF AC PF12701.11
#=GF DE Scd6-like Sm domain
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF SE Anantharaman V
#=GF GA 30.00 30.00;
#=GF TC 30.00 30.00;
#=GF NC 29.90 29.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0010
#=GF RN [1]
#=GF RM 15257761
#=GF RT Novel conserved domains in proteins with predicted roles in
#=GF RT eukaryotic cell-cycle regulation, decapping and RNA stability.
#=GF RA Anantharaman V, Aravind L;
#=GF RL BMC Genomics. 2004;5:45.
#=GF RN [2]
#=GF RM 15225602
#=GF RT Novel Sm-like proteins with long C-terminal tails and associated
#=GF RT methyltransferases.
#=GF RA Albrecht M, Lengauer T;
#=GF RL FEBS Lett 2004;569:18-26.
#=GF RN [3]
#=GF RM 17074753
#=GF RT RAP55, a cytoplasmic mRNP component, represses translation in
#=GF RT Xenopus oocytes.
#=GF RA Tanaka KJ, Ogawa K, Takagi M, Imamoto N, Matsumoto K, Tsujimoto
#=GF RA M;
#=GF RL J Biol Chem. 2006;281:40096-40106.
#=GF RN [4]
#=GF RM 18723115
#=GF RT RAP55: insights into an evolutionarily conserved protein family.
#=GF RA Marnef A, Sommerville J, Ladomery MR;
#=GF RL Int J Biochem Cell Biol. 2009;41:977-981.
#=GF RN [5]
#=GF RM 17923697
#=GF RT A divergent Sm fold in EDC3 proteins mediates DCP1 binding and
#=GF RT P-body targeting.
#=GF RA Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S,
#=GF RA Schmidt S, Coles M, Izaurralde E, Weichenrieder O;
#=GF RL Mol Cell Biol. 2007;27:8600-8611.
#=GF DR INTERPRO; IPR025609;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The Scd6-like Sm domain is found in Scd6p from S. cerevisiae,
#=GF CC Rap55 from the newt Pleurodeles walt, and its orthologs from
#=GF CC fungi, animals, plants and apicomplexans [1]. The domain is
#=GF CC also found in Dcp3p and the human EDC3/FLJ21128 protein where
#=GF CC it is fused to the the Rossmanoid YjeF-N domain [1,2]. In
#=GF CC addition both EDC3 and Scd6p are found fused to the FDF domain
#=GF CC [1,2].
#=GF SQ 5129
#=GS A0A4U5U6A7_COLLU/7-81 AC A0A4U5U6A7.1
#=GS A0A6J1P2R5_BICAN/6-80 AC A0A6J1P2R5.1
#=GS A0A819J1W8_9BILA/22-96 AC A0A819J1W8.1
#=GS A0A091RDV2_9GRUI/4-67 AC A0A091RDV2.1
#=GS A0A507AZK4_9PEZI/2-67 AC A0A507AZK4.1
#=GS A0A168DQJ2_9EURO/5-81 AC A0A168DQJ2.1
#=GS A0A6P9A067_THRPL/6-80 AC A0A6P9A067.1
#=GS A0A7K5AGU4_9FURN/1-42 AC A0A7K5AGU4.1
#=GS A0A8C3XIR0_CHESE/6-80 AC A0A8C3XIR0.1
#=GS A0A7L2XVZ1_9PASS/1-42 AC A0A7L2XVZ1.1
#=GS A0A8I5NNF1_PAPAN/55-129 AC A0A8I5NNF1.1
#=GS A0A851CWF7_CALVR/1-40 AC A0A851CWF7.1
#=GS A0A6P5JST0_PHACI/8-82 AC A0A6P5JST0.1
#=GS A0A8C9CKL4_PHOSS/6-80 AC A0A8C9CKL4.1
#=GS A0A851U7K5_9PASS/6-80 AC A0A851U7K5.1
#=GS B9HWN3_POPTR/22-97 AC B9HWN3.1
#=GS S8CFS0_9LAMI/1-31 AC S8CFS0.1
#=GS A0A7K8T3P4_9AVES/4-67 AC A0A7K8T3P4.1
#=GS A0A067MLG3_9AGAM/1-38 AC A0A067MLG3.1
#=GS SCD6_YEAST/3-79 AC P45978.1
#=GS A0A3Q7RHQ0_CALUR/4-67 AC A0A3Q7RHQ0.1
#=GS A0A1S3P263_SALSA/6-80 AC A0A1S3P263.1
#=GS A0A6J0KTV7_RAPSA/17-92 AC A0A6J0KTV7.1
#=GS A0A7L1HFE4_9CHAR/1-42 AC A0A7L1HFE4.1
#=GS A0A7L2H994_SAGSE/4-67 AC A0A7L2H994.1
#=GS A0A2U3WMN6_ODORO/8-82 AC A0A2U3WMN6.1
#=GS A0A2K5SJQ4_CEBIM/6-79 AC A0A2K5SJQ4.1
#=GS A0A7J8CJD0_ROUAE/6-80 AC A0A7J8CJD0.1
#=GS L14BA_XENLA/6-80 AC Q68FI1.1
#=GS A0A1U8HTW1_GOSHI/16-91 AC A0A1U8HTW1.1
#=GS G3B4T8_CANTC/3-82 AC G3B4T8.1
#=GS DCP5L_ARATH/32-107 AC Q9FH77.1
#=GS A0A1E3HGR8_9TREE/7-81 AC A0A1E3HGR8.1
#=GS A0A6P6MF37_CARAU/6-80 AC A0A6P6MF37.1
#=GS A0A8W8K0F6_CRAGI/6-80 AC A0A8W8K0F6.1
#=GS A0A7K8GA30_ORTSP/1-42 AC A0A7K8GA30.1
#=GS H2UTT3_TAKRU/7-81 AC H2UTT3.2
#=GS Q6BQ48_DEBHA/3-82 AC Q6BQ48.2
#=GS A0A452E381_CAPHI/8-82 AC A0A452E381.1
#=GS A0A1Q3E2D8_LENED/4-79 AC A0A1Q3E2D8.1
#=GS A0A850UAJ3_GRUAM/6-80 AC A0A850UAJ3.1
#=GS A0A2K6EUN4_PROCO/8-82 AC A0A2K6EUN4.1
#=GS A0A7L4AMU1_9CHAR/1-42 AC A0A7L4AMU1.1
#=GS A0A0V0SCC5_9BILA/4-78 AC A0A0V0SCC5.1
#=GS A0A370TRU3_9HELO/3-79 AC A0A370TRU3.1
#=GS A0A8C4QUZ4_EPTBU/6-80 AC A0A8C4QUZ4.1
#=GS M0ZY15_SOLTU/11-86 AC M0ZY15.1
#=GS A0A1E4SU14_9ASCO/3-79 AC A0A1E4SU14.1
#=GS A0A4W2IM25_BOBOX/6-80 AC A0A4W2IM25.1
#=GS A0A7L3T4M5_RISTR/4-67 AC A0A7L3T4M5.1
#=GS A0A7J8C976_MOLMO/6-80 AC A0A7J8C976.1
#=GS A0A835XFX5_9CHLO/4-79 AC A0A835XFX5.1
#=GS A0A812DK27_SEPPH/7-81 AC A0A812DK27.1
#=GS A0A8C3PDJ5_CHRPI/4-67 AC A0A8C3PDJ5.1
#=GS A0A671TI66_SPAAU/6-80 AC A0A671TI66.1
#=GS A0A2K5MIK4_CERAT/8-82 AC A0A2K5MIK4.1
#=GS A0A8C3JDI2_9CHAR/6-80 AC A0A8C3JDI2.1
#=GS A0A6P5S4Z0_PRUAV/8-83 AC A0A6P5S4Z0.1
#=GS L8IQ19_9CETA/28-76 AC L8IQ19.1
#=GS A0A7K6N9N4_PEDTO/1-42 AC A0A7K6N9N4.1
#=GS A0A8H8JH92_9AGAM/6-81 AC A0A8H8JH92.1
#=GS A0A4U1EPN8_MONMO/18-91 AC A0A4U1EPN8.1
#=GS A0A0J7NZN4_LASNI/6-80 AC A0A0J7NZN4.1
#=GS A0A2I3RCV4_PANTR/6-80 AC A0A2I3RCV4.1
#=GS A0A850WT16_PIACA/6-80 AC A0A850WT16.1
#=GS A0A093NI41_PYGAD/6-80 AC A0A093NI41.1
#=GS A0A5J5AH86_9ASTE/14-89 AC A0A5J5AH86.1
#=GS A0A8J4UI51_CLAMG/6-80 AC A0A8J4UI51.1
#=GS A0A232FK17_9HYME/6-80 AC A0A232FK17.1
#=GS A0A2U4BTQ9_TURTR/6-80 AC A0A2U4BTQ9.1
#=GS A0A8C8J2S1_ONCTS/6-80 AC A0A8C8J2S1.1
#=GS A0A852CCP9_9PICI/6-80 AC A0A852CCP9.1
#=GS A0A8C6U1F2_9GOBI/7-81 AC A0A8C6U1F2.1
#=GS A0A2I3GCH7_NOMLE/6-80 AC A0A2I3GCH7.1
#=GS F0ZLC6_DICPU/4-78 AC F0ZLC6.1
#=GS A0A7K6C8B1_PTIVI/1-42 AC A0A7K6C8B1.1
#=GS A0A7K9K2G1_9PASE/1-42 AC A0A7K9K2G1.1
#=GS A0A091WA71_OPIHO/4-67 AC A0A091WA71.1
#=GS A0A7N0UDZ7_KALFE/14-89 AC A0A7N0UDZ7.1
#=GS A0A8J6E9Y7_ELECQ/1-45 AC A0A8J6E9Y7.1
#=GS A0A673MTZ9_9TELE/6-80 AC A0A673MTZ9.1
#=GS A0A7K6A5J9_ONYCO/6-80 AC A0A7K6A5J9.1
#=GS A0A091EQI7_FUKDA/70-134 AC A0A091EQI7.1
#=GS A0A1U8M7Q3_GOSHI/16-91 AC A0A1U8M7Q3.1
#=GS A0A4W5RH63_9TELE/6-80 AC A0A4W5RH63.1
#=GS A0A2T9YHN5_9FUNG/5-68 AC A0A2T9YHN5.1
#=GS A0A7K8HPL7_9CORV/1-42 AC A0A7K8HPL7.1
#=GS B4KZK2_DROMO/7-70 AC B4KZK2.1
#=GS A0A7L4NJG4_9AVES/1-42 AC A0A7L4NJG4.1
#=GS A0A8J2HZV5_9PLEO/3-78 AC A0A8J2HZV5.1
#=GS A0A8J4KMD0_EUDCH/4-67 AC A0A8J4KMD0.1
#=GS A0A4W5LID8_9TELE/44-118 AC A0A4W5LID8.1
#=GS A0A834R7R5_SARSC/14-88 AC A0A834R7R5.1
#=GS A0A6J1CDA6_MOMCH/17-92 AC A0A6J1CDA6.1
#=GS A0A4U0VAY5_9PEZI/3-79 AC A0A4U0VAY5.1
#=GS A0A8H4H400_9EURO/15-88 AC A0A8H4H400.1
#=GS A0A6P6A356_DURZI/17-92 AC A0A6P6A356.1
#=GS L7N0Y1_MYOLU/8-82 AC L7N0Y1.1
#=GS B4QNW4_DROSI/7-70 AC B4QNW4.1
#=GS A0A6P6JH01_CARAU/6-80 AC A0A6P6JH01.1
#=GS G1RWV2_NOMLE/4-67 AC G1RWV2.2
#=GS A0A7K9IE56_9AVES/1-42 AC A0A7K9IE56.1
#=GS M4D7T9_BRARP/29-92 AC M4D7T9.1
#=GS A0A667IRD1_LYNCA/6-80 AC A0A667IRD1.1
#=GS A0A8C4Y159_9SAUR/6-80 AC A0A8C4Y159.1
#=GS A0A3Q1FIN9_9TELE/4-67 AC A0A3Q1FIN9.1
#=GS A0A8B9G229_9PSIT/6-80 AC A0A8B9G229.1
#=GS A0A517LMG7_9PEZI/3-79 AC A0A517LMG7.1
#=GS A0A6J1I9N9_CUCMA/15-90 AC A0A6J1I9N9.1
#=GS A0A066WDQ7_9AGAM/6-81 AC A0A066WDQ7.1
#=GS A0A3Q7P3F1_CALUR/6-80 AC A0A3Q7P3F1.1
#=GS A0A663DVA5_AQUCH/6-80 AC A0A663DVA5.1
#=GS A0A0F8UUW4_9EURO/5-81 AC A0A0F8UUW4.1
#=GS A0A8B9B8Q5_9AVES/6-80 AC A0A8B9B8Q5.1
#=GS A0A1U7XF76_NICSY/14-89 AC A0A1U7XF76.1
#=GS A0A3B1JB77_ASTMX/6-80 AC A0A3B1JB77.1
#=GS A0A2K5C374_AOTNA/6-80 AC A0A2K5C374.1
#=GS A0A2I3I000_NOMLE/1-39 AC A0A2I3I000.1
#=GS A0A8K0HBM3_9ROSA/12-87 AC A0A8K0HBM3.1
#=GS A0A6P6UYL5_COFAR/23-98 AC A0A6P6UYL5.1
#=GS A0A7K8J5C1_9PASS/6-80 AC A0A7K8J5C1.1
#=GS A0A6J8B303_MYTCO/6-80 AC A0A6J8B303.1
#=GS A0A364N166_9PLEO/2-66 AC A0A364N166.1
#=GS A0A091V3A8_NIPNI/6-80 AC A0A091V3A8.1
#=GS A0A0E0E277_9ORYZ/10-85 AC A0A0E0E277.1
#=GS A0A7J6LVD2_PERCH/7-80 AC A0A7J6LVD2.1
#=GS A0A061G891_THECC/5-50 AC A0A061G891.1
#=GS A0A2K5YI23_MANLE/1-39 AC A0A2K5YI23.1
#=GS A0A3Q1LIY5_BOVIN/6-80 AC A0A3Q1LIY5.1
#=GS A0A7F8RU37_LEPWE/8-82 AC A0A7F8RU37.1
#=GS A0A6P3HXB9_BISBI/6-80 AC A0A6P3HXB9.1
#=GS A0A2K5YI14_MANLE/1-39 AC A0A2K5YI14.1
#=GS A0A2K6T0G7_SAIBB/7-79 AC A0A2K6T0G7.1
#=GS A0A3M6V7K0_9STRA/22-95 AC A0A3M6V7K0.1
#=GS A0A7J7I117_CAMSI/14-89 AC A0A7J7I117.1
#=GS A0A0E0FF68_ORYNI/34-109 AC A0A0E0FF68.1
#=GS A0A8B8HWJ1_VANTA/6-80 AC A0A8B8HWJ1.1
#=GS A0A7L4L132_9CORV/4-67 AC A0A7L4L132.1
#=GS A0A074WDV5_9PEZI/3-79 AC A0A074WDV5.1
#=GS A0A1U7W0R9_NICSY/30-105 AC A0A1U7W0R9.1
#=GS A0A0U5CRQ0_ASPCI/5-81 AC A0A0U5CRQ0.1
#=GS A0A5F8GKK7_MONDO/8-82 AC A0A5F8GKK7.1
#=GS A0A0U1LJ61_TALIS/5-81 AC A0A0U1LJ61.1
#=GS A0A8C2VUU7_CHILA/6-80 AC A0A8C2VUU7.1
#=GS A0A8C6E915_MOSMO/8-82 AC A0A8C6E915.1
#=GS A0A8C0BI51_9AVES/6-80 AC A0A8C0BI51.1
#=GS A0A6P7KAG7_9TELE/6-80 AC A0A6P7KAG7.1
#=GS A0A1S3KCZ9_LINUN/4-67 AC A0A1S3KCZ9.1
#=GS A0A7L0MVI7_9PSIT/4-67 AC A0A7L0MVI7.1
#=GS A0A6P8ITX6_ACTTE/5-79 AC A0A6P8ITX6.1
#=GS A0A8D2HD17_UROPR/8-82 AC A0A8D2HD17.1
#=GS A0A852CGU7_9PICI/1-42 AC A0A852CGU7.1
#=GS A0A6A6YSG3_9PEZI/3-78 AC A0A6A6YSG3.1
#=GS A0A7L2VH54_9AVES/1-42 AC A0A7L2VH54.1
#=GS A0A814LJW5_9BILA/9-83 AC A0A814LJW5.1
#=GS A0A3P9CZV4_9CICH/6-80 AC A0A3P9CZV4.1
#=GS A0A852PH68_9PASS/6-80 AC A0A852PH68.1
#=GS A0A5J9UGF6_9POAL/33-108 AC A0A5J9UGF6.1
#=GS A0A8J6ET67_ELECQ/1-40 AC A0A8J6ET67.1
#=GS A0A2K5SJQ7_CEBIM/6-79 AC A0A2K5SJQ7.1
#=GS A0A8C0VRT6_CYACU/4-67 AC A0A8C0VRT6.1
#=GS A0A433PTC4_9FUNG/73-144 AC A0A433PTC4.1
#=GS A0A1S3EI08_CICAR/20-95 AC A0A1S3EI08.1
#=GS A0A2K1K5Z7_PHYPA/12-87 AC A0A2K1K5Z7.1
#=GS A0A4Q4UAL7_9PEZI/3-79 AC A0A4Q4UAL7.1
#=GS A0A498MRM7_LABRO/6-80 AC A0A498MRM7.1
#=GS A0A2J7QNG1_9NEOP/6-80 AC A0A2J7QNG1.1
#=GS A0A2K6UMX7_SAIBB/1-39 AC A0A2K6UMX7.1
#=GS A0A1S3Y7M2_TOBAC/22-97 AC A0A1S3Y7M2.1
#=GS A0A3P7N8R6_DIBLA/13-94 AC A0A3P7N8R6.1
#=GS A0A8U0URW8_MUSPF/8-82 AC A0A8U0URW8.1
#=GS A0A6P4ZII7_BRABE/6-80 AC A0A6P4ZII7.1
#=GS A0A212CSI5_CEREH/4-67 AC A0A212CSI5.1
#=GS A0A0H1BE43_9EURO/5-81 AC A0A0H1BE43.1
#=GS A0A1V6TFK6_9EURO/5-81 AC A0A1V6TFK6.1
#=GS A0A8B9DCJ1_ANSCY/6-80 AC A0A8B9DCJ1.1
#=GS A0A670YBZ9_PSETE/6-80 AC A0A670YBZ9.1
#=GS A0A8U0N2U8_MUSPF/6-80 AC A0A8U0N2U8.1
#=GS A0A7J9EJ02_9ROSI/1-40 AC A0A7J9EJ02.1
#=GS A0A061ANT0_CYBFA/3-79 AC A0A061ANT0.1
#=GS A0A0L8I833_OCTBM/3-66 AC A0A0L8I833.1
#=GS A0A161Y525_9PEZI/72-148 AC A0A161Y525.1
#=GS A0A8B8M413_ABRPR/20-95 AC A0A8B8M413.1
#=GS A0A0E0PY89_ORYRU/11-86 AC A0A0E0PY89.1
#=GS A0A803WA17_FICAL/6-80 AC A0A803WA17.1
#=GS A0A2R5GNR1_9STRA/4-79 AC A0A2R5GNR1.1
#=GS A0A7K4JPR3_GEOCA/1-42 AC A0A7K4JPR3.1
#=GS A0A3P8W1E3_CYNSE/4-67 AC A0A3P8W1E3.1
#=GS A0A2S7P6B6_9HELO/2-67 AC A0A2S7P6B6.1
#=GS A0A6F9BTA3_9TELE/4-67 AC A0A6F9BTA3.1
#=GS A0A8B8ER80_CRAVI/6-80 AC A0A8B8ER80.1
#=GS A0A1S3MK89_SALSA/45-119 AC A0A1S3MK89.1
#=GS Q7RX24_NEUCR/3-79 AC Q7RX24.2
#=GS A0A6J1TYM4_9SAUR/6-80 AC A0A6J1TYM4.1
#=GS A0A6H5L3S6_9PHAE/9-65 AC A0A6H5L3S6.1
#=GS A0A851Q2M4_ANHAN/6-80 AC A0A851Q2M4.1
#=GS A0A813UDG4_9BILA/4-79 AC A0A813UDG4.1
#=GS A0A803LAR9_CHEQI/16-91 AC A0A803LAR9.1
#=GS A0A4Z2BEN4_9TELE/7-81 AC A0A4Z2BEN4.1
#=GS A0A7L1U0K6_PHANI/1-40 AC A0A7L1U0K6.1
#=GS A0A315VSN2_GAMAF/4-67 AC A0A315VSN2.1
#=GS A0A8D0A2R5_SANLU/6-80 AC A0A8D0A2R5.1
#=GS A0A5B0PHK6_PUCGR/4-80 AC A0A5B0PHK6.1
#=GS A0A7K6H944_9PASS/6-80 AC A0A7K6H944.1
#=GS A0A4T0WUU3_9ASCO/3-79 AC A0A4T0WUU3.1
#=GS A0A8H8DES2_9FUNG/4-79 AC A0A8H8DES2.1
#=GS A0A3M9YCB9_9PEZI/3-79 AC A0A3M9YCB9.1
#=GS A0A0D2J861_9CHLO/9-84 AC A0A0D2J861.1
#=GS A0A8H6L0U0_9LECA/3-77 AC A0A8H6L0U0.1
#=GS A0A5C7HIT1_9ROSI/18-93 AC A0A5C7HIT1.1
#=GS A0A0P9GZ86_RHOGW/4-80 AC A0A0P9GZ86.1
#=GS A0A2Y9THD8_PHYMC/6-80 AC A0A2Y9THD8.1
#=GS A0A5M3YTR5_ASPTE/5-81 AC A0A5M3YTR5.1
#=GS A0A087Y2F8_POEFO/4-67 AC A0A087Y2F8.1
#=GS A0A2U9BGY8_SCOMX/8-82 AC A0A2U9BGY8.1
#=GS A0A452SKN5_URSAM/25-78 AC A0A452SKN5.1
#=GS A0A8B8MY95_9MYRT/10-85 AC A0A8B8MY95.1
#=GS A0A6P4HWD9_DROKI/6-80 AC A0A6P4HWD9.1
#=GS A0A3Q3X620_MOLML/6-80 AC A0A3Q3X620.1
#=GS A0A7K9Q7G0_IRECY/4-67 AC A0A7K9Q7G0.1
#=GS A0A7K6F0E8_9CORV/1-42 AC A0A7K6F0E8.1
#=GS A0A8P4JZ33_DICLA/6-80 AC A0A8P4JZ33.1
#=GS A0A8C6S4H4_9GOBI/7-81 AC A0A8C6S4H4.1
#=GS A0A672F483_SALFA/7-81 AC A0A672F483.1
#=GS A0A0E0LBW4_ORYPU/10-85 AC A0A0E0LBW4.1
#=GS A0A7L1ILA6_SMUAF/6-80 AC A0A7L1ILA6.1
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A0A7K6IQ56_9CORV/1-42 ...............ap-----..---.----...-.--..-...........-.......-.......--......-.----...--...-.-...-...-..----........................................................V..R..SFGTED...........R.P.....T............D......RP........AP.....PR.EE........I...YEY.....IIFR..GSDIKDITVCEP..........................................
A0A7L2C9Q1_9PASS/6-80 .................PYIGS..KIS.LISK...A.EI..R...........Y.......E.......GI......L.YTID...TE...N.S...T...V..ALAK........................................................V..R..SFGTED...........R.P.....T............D......RP........IP.....PR.DE........V...FEY.....IIFR..GSDIKDLTVCEP..........................................
A0A250Y164_CASCN/6-80 .................PYIGS..KIS.LISK...A.EI..R...........Y.......E.......GI......L.YTID...TE...N.S...T...V..ALAK........................................................V..R..SFGTED...........R.P.....T............D......RP........IP.....PR.DE........V...FEY.....IIFR..GSDIKDLTVCEP..........................................
#=GC seq_cons ..................alGS..hIS.LlSK...u.pI..R...........Y.......p.......Gh......L.asI-...sp...s.S...T...l..uLtp........................................................V..R..SFGTEs...........R.......s............s......t.........lP.....Pp.-c........l...aEY.....IlFR..GSDIKDLpVpE...........................................
//
