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Database: Pfam
Entry: LcrV
LinkDB: LcrV
Original site: LcrV 
#=GF ID   LcrV
#=GF AC   PF04792.13
#=GF DE   V antigen (LcrV) protein
#=GF AU   Waterfield DI;0000-0003-2885-5126
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_6155 (release 7.5)
#=GF GA   25.00 25.00;
#=GF TC   62.80 43.00;
#=GF NC   22.00 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   LcrV
#=GF RN   [1]
#=GF RM   9642196
#=GF RT   The V antigen of Yersinia pestis regulates Yop vectorial
#=GF RT   targeting as well as Yop secretion through effects on YopB and
#=GF RT   LcrG. 
#=GF RA   Nilles ML, Fields KA, Straley SC; 
#=GF RL   J Bacteriol 1998;180:3410-3420.
#=GF RN   [2]
#=GF RM   7730287
#=GF RT   Differential effects of deletions in lcrV on secretion of V
#=GF RT   antigen, regulation of the low-Ca2+ response, and virulence of
#=GF RT   Yersinia pestis. 
#=GF RA   Skrzypek E, Straley SC; 
#=GF RL   J Bacteriol 1995;177:2530-2542.
#=GF DR   INTERPRO; IPR005413;
#=GF DR   SCOP; 1r6f; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Yersinia pestis, the aetiologic agent of plague, secretes a set
#=GF CC   of environmentally regulated, plasmid pCD1-encoded virulence
#=GF CC   proteins termed Yops and V antigen (LcrV) by a type III
#=GF CC   secretion mechanism. LcrV is a multifunctional protein that has
#=GF CC   been shown to act at the level of secretion control by binding
#=GF CC   the Ysc inner-gate protein LcrG and to modulate the host immune
#=GF CC   response by altering cytokine production.  LcrV is also
#=GF CC   necessary for full induction of low-calcium response (LCR)
#=GF CC   stimulon virulence gene transcription.  Family members are not
#=GF CC   confined to Yersinia pestis [1,2].   
#=GF SQ   12
#=GS A0A2A2KJC5_9BILA/113-316  AC A0A2A2KJC5.1
#=GS LCRV_YERPE/1-323          AC P0C7U7.1
#=GS LCRV_YERPE/1-323          DR PDB; 4JBU A; 28-319;
#=GS LCRV_YERPE/1-323          DR PDB; 1R6F A; 28-322;
#=GS U3CHY8_9VIBR/322-609      AC U3CHY8.1
#=GS G3XD49_PSEAE/71-294       AC G3XD49.1
#=GS D0Z4V9_PHODD/397-608      AC D0Z4V9.1
#=GS A0A1D9IKR6_9PSED/2-314    AC A0A1D9IKR6.1
#=GS A0A0W7U448_9GAMM/2-273    AC A0A0W7U448.1
#=GS Q7N0X1_PHOLL/2-304        AC Q7N0X1.1
#=GS B6VK26_PHOAA/2-318        AC B6VK26.1
#=GS Q87P59_VIBPA/385-607      AC Q87P59.1
#=GS A0A0W7U448_9GAMM/227-373  AC A0A0W7U448.1
#=GS E3BLV6_9VIBR/671-753      AC E3BLV6.1
A0A2A2KJC5_9BILA/113-316             ..............................................................qlvnlgerls--------------------------------------------------------.-------------------------------------------------....--..-........--------..--------------MDELVMAAMGLRMRKQKTERTELSEQLKSLTAELKIFSVIQSKVNVVM..ADK.G..TFDLQD....PG....FN.LFDPNLYD..L-.DAAAWETSPEHRLLASYGTAAVTVQqflAAKPTGLSPDSSVHRRHRVSGPMD..DLK..AEYTWHKDNNPLANFSQALSDRTRIVNDRVTEKTTLLNDAGSRYTTSTEVMMKFVETWFSMLSKIMQ--n...
LCRV_YERPE/1-323                     ........................................................................MIRAYEQNPQHFIEDLEKVRVEQLTGHGSSVLEELVQLVKDKNIDISIKYDPRKDS.EVFANRVITDDIELLKKILAYFLPEDAILKGGHYDNQLQNGIKRVKEFL....ES..S........PNTQWELR..AFMAVMHFSLTADRIDDDILKVIVDSMNHHGDARSKLREELAELTAELKIYSVIQAEINKHL..SSS.G..TINIHD....KS....IN.LMDKNLYG..YT.DEEIFKASAEYKILEKMPQTTIQVD...GSEKKIVSIKDFLGSENKRTGALG..NLK..NSYSYNKDNNELSHFATTCSDKSRPLNDLVSQKTTQLSDITSRFNSAIEALNRFIQKYDSVMQRLLDDT....
#=GR LCRV_YERPE/1-323          SS    ........................................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXEHHHHHHHHHHHHHTT-EEEE---TTT-S.S----EEGCC-HHHHHHHHHHHS-HHHCHT-EE--HHHHHHHHHHHHHH....HH..S........SSSEEEHH..HHHHHHHHHHSTT---HHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..HCC.S..EEE-ST....TS....--.TT-GGGCT..-S.SHHHHHTSHHHHHHTTS--EEEEET...TCEEEE--HHHHHT-SSSTT---S..S--..SEEES--------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCTTT-X....
U3CHY8_9VIBR/322-609                 katvnaeidqllvdlkdvkqqlelpqniktikqvvgqdisvlfekmaqgqsvetdfitrhkkllanlaqfse--------------------------------------------------------.------------------------------------HLKNNIQS---QT....DS..T.......qDNNEYVLKglDLFALID-ASTGDRLDDKILNALDEMRQGQFNKRDEIKNELEELTIILNLYNLIQAAIHNAQ..SGE.G..KYNINQ....E-....--.-FKPEDFG..YS.TQEEFENSPEFAFLNSQN-------...---PPITSHKGFLEQQGLDIDTSQ..NSG..IYEDTEDDGNKLSNLSTAISDKSKIVNTDVQLKTEEFSKMNSDYNATIQAMNQIVQKFISVLTDILR--sf..
G3XD49_PSEAE/71-294                  .....................................................................pgq--------------------------------------------------------.----------------------------------------GLEVLREVL....QArrQ........PGAQWDLR..EFLVSAYFSLH-GRLDEDVIGVYKDVLQTQDGKRKALLDELKALTAELKVYSVIQSQINAAL..SAK.Q..GIRIDA....GG....ID.LVDPTLYG..YAvGDPRWKDSPEYALLSNLD----TFS...GK----LSIKDFLSGSPKQSGELK..GLS..DEYPFEKDNNPVGNFATTVSDRSRPLNDKVNEKTTLLNDTSSRYNSAVEALNRFIQKYDSVLRDILSAI....
D0Z4V9_PHODD/397-608                 .......................................................lskitkeekdnkavnae--------------------------------------------------------.-------------------------------------------------....--..-........--HALTAR..DLLSVIESSI-GDRFDERVLFALNERRVNRLEKRNEQKQVLEELTIRLKFFGVVQSRIHSFQ..SRD.A..SYD--P....FG....VEgRFKASDFN..YS.NDNEFKASPEYKYLSKNK---IE--...-------KHGDFLR----KEGLTV..PYD..VSYQDTKDNKKLSNFSSSVSDKSKLLNDEVQIKTTELNDTSSQYNSTVEAMNKFVQKYHSILQEILRAI....
A0A1D9IKR6_9PSED/2-314               ................................................................sishyskt---------TPFLSDLNGASLDQLRGKDTRALADLQQTLGRLNIRVT------HDG.T-----PLT--PEQMTKVLAYLLPPQAQVANGWYASQTQSGLEAVKKTLaayaKA..H........PATPWPLS..DFLALTHADLTSDTLDDDVIDVYVAVMEQQDAKRLTLRDELTSLTGELSIYSVVQAQINARL..SSK.S..AINIED....TSattgLN.LLDKTLYG..YS.EGSRWLKSAEYALLTGMD------T...GKGKTRISIKDFLSGVPKESGAIKavDLK..PDYPFEKDNNPVANLATTVGDRARPLNDKVSEKTTLLNDVSSRYNAAIEALNRFVQKHDSLLRDILNAI....
A0A0W7U448_9GAMM/2-273               ........................................................................QIRSYNDNPQGFLDDLGRVNLDQLTGSHSSELDPLLRFIREKGIQIS-----ASGS.SPFI------NEELLKKMLAYFMPEDAIVKGGHLDRQIRGGIEHLKELL....TS..AvagsptaaAKTTWSLQ..EFMAMAHFSLTGDRVDDDVIGVIRDTMTSHNDKRNDLKVQVTKLTAELKIYSLIQSSISSAQshSSD.N..SLSTSDpnwsRF....LN.LNDHRNYG..VS.TYDKFMESAEFSLIAPMLVA--NMD...AST--AAQARPILESINQLDNALK..GDKytDAESRQRDKNLLS--------------------------------------------------------eqra
Q7N0X1_PHOLL/2-304                   ........................................................................EIRPYQNDPQLFLADLEKVSLAQLQGSGSSELDRLVNLIFDKGIKIT------SDS.S-----VVTENKELLKKLIAYFLPADAVVEGGHLDSQIKNGINNLESFL....NS..S........TLKTWTLK..DFLAAVHFNLTPDRLDDDVIDIFVSVMSGHDKKRLELRDELATLTAELKIYSVIQSEINAKL..AAN.G..ELKIDD....NS....FN.LLDHKKYG..FS.DQPTFEKSAEYKLLRKIS------S...GSE---ISIKTFLESSNKQSGAMA..GLE..NSYEYDKENNRLANFSTSVNDRVSPLNNTVQEKTTRLNEASSRYNAAIEALNRFIQKYDSIIRNILGAI....
B6VK26_PHOAA/2-318                   ........................................................................EIRSYHSNPQHFLDDLKSVQPEQLQGSKSSELDGLVQLILAKGIKIEVKYDPSKDDgPSFDPKVITDDKELLKKLIAYFLPADAVVKDGHLDSQIKNGIDNLKSFL....NN..Q........ASTTWTLR..DFLSVVHFNLTPDRLDDDVIEVFTSVMLRHDEKRRQLRDELAELTAELKIYSVIQSEINAKL..SAKdGeqKLSIDS....TS....FD.LRDYKKYG..FS.DETAFAESTEYKLLNKIS-------...-SE--PISIKAFLESPDKHSGAMK..GLA..NSYEYDKDNNRLANFSTSVNDRVNPLNNSVQERTTRLNDVSSRFNAAIEALNRFIQKYDSIMRNILGAI....
Q87P59_VIBPA/385-607                 .................................................................etlrknl--------------------------------------------------------.-------------------------------GALKDRLLNITEQEKKDL....EV..R........AEHSLTAR..DLLAVVESSI-GDRFDEQVLFALNERRVNRLEKRNEQKEALQDLTVQLKIFGVVQSKIHSTQ..SVD.G..TYKPDD....NA....FS.ASDFNYNS..VT.D---FQNSPEYKYLTDNG-------...-----ITTHTDFL----KKQGVTV..ADG..ASFKDEEKTKKLSNFSSSVSDKSKLLNDEVQIKTTELNDISSQYNSTVEAMNKFVQKYHSILQEILRAI....
A0A0W7U448_9GAMM/227-373             ..........................................................nmdastaaqarpil--------------------------------------------------------.-------------------------------------------------....--..-........--------..--------------------------------------------------------------..---.-..------....ES....IN.QLDNALKGdkYT.DAESRQRDK-NLLSEQRAQFKSLVS...GRP---LSMKQFLESPLKDTGALT..GVS..DSYSYNKDNNKLGNFATTVSDKSKPLNDKLSQKTTELNDISSRYNSAIEALNKFIQKYESMMQQILQAI....
E3BLV6_9VIBR/671-753                 .........................................................vdfltnkinnfdtav--------------------------------------------------------.-------------------------------------------------....--..-........--------..--------------------------------------------------------------..---.-..------....--....--.--------..--.-------------------------...------------------------..---..-TYQDTKDSQKLSNLSNQLSETTKLVNTDVQLKTTDLNDTNSQYLNTIEAMNKFIQKYMNIIETILRAI....
#=GC SS_cons                         ........................................................................XXXXXXXXXXXXXXXXXXXXXXXXXXXEHHHHHHHHHHHHHTT-EEEE---TTT-S.S----EEGCC-HHHHHHHHHHHS-HHHCHT-EE--HHHHHHHHHHHHHH....HH..S........SSSEEEHH..HHHHHHHHHHSTT---HHHHHHHHHHHHTT--HHHHHHHHHHHHHHHHHHHHHHHHHHHHHH..HCC.S..EEE-ST....TS....--.TT-GGGCT..-S.SHHHHHTSHHHHHHTTS--EEEEET...TCEEEE--HHHHHT-SSSTT---S..S--..SEEES--------------------HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCTTT-X....
#=GC seq_cons                        ..........................................................................................................................................................................hp.....h....ps..t........s.pthshp..-hhuhhc.sl.sDRhD-cVltshsphh.pp.pKRppl+ppLtpLTscLKlauVlQupIpst...Ssc.u..phphps....pu....hs.hhD.phaG..ao.stttappSsEatlLsphs...........t....hSh+sFLpt..+psGsht..shp..ssYphpKDNNcLuNFuoolSD+o+.LNscVp.KTTpLNDhoScYNuslEAhN+FlQKYcSllppILpAI....
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