#=GF ID   Ldr_toxin
#=GF AC   PF13940.10
#=GF DE   Toxin Ldr, type I toxin-antitoxin system
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   Jackhmmer:E8XFD8
#=GF GA   27.00 27.00;
#=GF TC   33.70 57.50;
#=GF NC   23.50 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   LdrD-RdlD_toxin-antitoxin_system
#=GF RN   [1]
#=GF RM   12123448
#=GF RT   Molecular characterization of long direct repeat (LDR) sequences
#=GF RT   expressing a stable mRNA encoding for a 35-amino-acid
#=GF RT   cell-killing peptide and a cis-encoded small antisense RNA in
#=GF RT   Escherichia coli.
#=GF RA   Kawano M, Oshima T, Kasai H, Mori H;
#=GF RL   Mol Microbiol. 2002;45:333-349.
#=GF DR   INTERPRO; IPR025253;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family includes the Ldr (long direct repeat) toxins. In
#=GF CC   Escherichia coli there are four Ldr toxins, LdrA, LdrB, LdrC and
#=GF CC   LdrD. These toxins inhibit cell growth, decrease cell viability
#=GF CC   and cause nucleoid condensation. LdrD expression is inhibited by
#=GF CC   the antisense RNA RdlD, which functions as an antitoxin [1].
#=GF SQ   18
#=GS A0A2Z5XJ93_ECO57/1-35   AC A0A2Z5XJ93.1
#=GS E3G9D9_ENTLS/1-35       AC E3G9D9.1
#=GS A0A248KIX9_9ENTR/53-87  AC A0A248KIX9.1
#=GS A0A2X4THV1_SALER/1-35   AC A0A2X4THV1.1
#=GS LDRB_ECOLI/1-35         AC Q6BF87.1
#=GS A0A4Z0L2P9_SALET/9-43   AC A0A4Z0L2P9.1
#=GS A0A2Z5XIW6_ECO57/1-35   AC A0A2Z5XIW6.1
#=GS A0A0H2V4C1_SHIFL/57-91  AC A0A0H2V4C1.1
#=GS A0A0H2V2Y9_SHIFL/46-80  AC A0A0H2V2Y9.1
#=GS D2TJW8_CITRI/1-35       AC D2TJW8.1
#=GS LDRA_ECOLI/1-35         AC P0DPD0.1
#=GS A0A859QKQ3_9ENTR/1-35   AC A0A859QKQ3.1
#=GS Q32GZ1_SHIDS/10-44      AC Q32GZ1.1
#=GS LDRD_ECOLI/1-35         AC Q6BF25.1
#=GS A0A0H2V2J2_SHIFL/57-91  AC A0A0H2V2J2.1
#=GS LDRC_ECOLI/1-35         AC P0DPD1.1
#=GS A0A2Z6FLG3_ECO57/1-35   AC A0A2Z6FLG3.1
#=GS A0A859QR49_9ENTR/1-35   AC A0A859QR49.1
A0A2Z5XJ93_ECO57/1-35              MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK.
E3G9D9_ENTLS/1-35                  MTLAQFGIAFWHDIAAPTVAAIIASLIVGWLESR-r
A0A248KIX9_9ENTR/53-87             MTLAQFGVAFWHDLAAPVIAGIITAAVVSWWRNRK.
A0A2X4THV1_SALER/1-35              MTLTQLGVAFWHDLAAPIIAGIIASLIVNWLRDRK.
LDRB_ECOLI/1-35                    MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK.
A0A4Z0L2P9_SALET/9-43              MTLTQLGVAFWHDLAAPIIAGIIASVIVNWLRDRK.
A0A2Z5XIW6_ECO57/1-35              MTLAQFAMIFWHDLAAPILAGIITAAIVGWWRNRK.
A0A0H2V4C1_SHIFL/57-91             MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK.
A0A0H2V2Y9_SHIFL/46-80             MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK.
D2TJW8_CITRI/1-35                  MTLIQLGIAFWHDLAAPAIAGIIAGMVVNWLRSRK.
LDRA_ECOLI/1-35                    MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK.
A0A859QKQ3_9ENTR/1-35              MTLAQLGLVLWGDLAAPVIAGILVSIIVSRMDNRK.
Q32GZ1_SHIDS/10-44                 MTLAQFAMIFWHDLAAPILAGIITVAIVGWWRNRK.
LDRD_ECOLI/1-35                    MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK.
A0A0H2V2J2_SHIFL/57-91             MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK.
LDRC_ECOLI/1-35                    MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK.
A0A2Z6FLG3_ECO57/1-35              MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK.
A0A859QR49_9ENTR/1-35              MTLAQLGLVLWDDLAAPVIAGILVSIIVSWMDNRK.
#=GC seq_cons                      MTLAQhGMsFWHDLAAPlIAGIIsuhIVsWhcsRK.
//