GenomeNet

Database: Pfam
Entry: Leptin
LinkDB: Leptin
Original site: Leptin 
#=GF ID   Leptin
#=GF AC   PF02024.15
#=GF DE   Leptin
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   PSI-blast P41159
#=GF GA   25.00 25.00;
#=GF TC   25.40 29.00;
#=GF NC   24.30 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Leptin
#=GF WK   Teleost_leptins
#=GF RN   [1]
#=GF RM   7984236
#=GF RT   Positional cloning of the mouse obese gene and its human
#=GF RT   homologue 
#=GF RA   Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM; 
#=GF RL   Nature 1994;372:425-432.
#=GF RN   [2]
#=GF RM   9144295
#=GF RT   Crystal structure of the obese protein leptin-E100. 
#=GF RA   Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson
#=GF RA   DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE,
#=GF RA   Smith DP, Zhang XY, Wery JP, Schevitz RW; 
#=GF RL   Nature 1997;387:206-209.
#=GF DR   INTERPRO; IPR000065;
#=GF DR   PRINTS; PR00495;
#=GF DR   SCOP; 1ax8; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF SQ   75
#=GS LEP_BOVIN/23-167         AC P50595.1
#=GS F6PLK2_ORNAN/23-167      AC F6PLK2.1
#=GS S9WRL3_CAMFR/45-189      AC S9WRL3.1
#=GS A0A1S3KQ23_SALSA/91-236  AC A0A1S3KQ23.1
#=GS A0A1U7QZV4_MESAU/23-167  AC A0A1U7QZV4.1
#=GS L9KXH7_TUPCH/23-167      AC L9KXH7.1
#=GS S7NUA4_MYOBR/1-93        AC S7NUA4.1
#=GS B0ZE71_AILME/23-167      AC B0ZE71.1
#=GS W5NWK7_SHEEP/61-204      AC W5NWK7.1
#=GS G5BHA4_HETGA/23-167      AC G5BHA4.1
#=GS LEP_MELGA/2-145          AC O93416.1
#=GS A0A2G9RRE5_LITCT/25-169  AC A0A2G9RRE5.1
#=GS W5LAC9_ASTMX/9-160       AC W5LAC9.1
#=GS LEP_RAT/23-167           AC P50596.1
#=GS F7HGW1_CALJA/23-167      AC F7HGW1.1
#=GS H2QVB5_PANTR/23-167      AC H2QVB5.1
#=GS LEP_GORGO/2-146          AC Q95189.1
#=GS LEP_CHICK/20-163         AC O42164.1
#=GS L5LF41_MYODS/23-167      AC L5LF41.1
#=GS LEP_MOUSE/23-167         AC P41160.1
#=GS G8BLB4_BOVIN/23-167      AC G8BLB4.1
#=GS A0A2D0QQV1_ICTPU/25-172  AC A0A2D0QQV1.1
#=GS A0A286XUJ2_CAVPO/23-165  AC A0A286XUJ2.1
#=GS F7GJN5_MACMU/23-167      AC F7GJN5.1
#=GS H2PNF0_PONAB/23-167      AC H2PNF0.1
#=GS G3QF76_GORGO/23-167      AC G3QF76.1
#=GS A0A2K5LMB9_CERAT/23-167  AC A0A2K5LMB9.1
#=GS G7P0L3_MACFA/23-167      AC G7P0L3.1
#=GS E9Q7Z0_MOUSE/23-98       AC E9Q7Z0.1
#=GS A0A091E2N1_FUKDA/90-234  AC A0A091E2N1.1
#=GS A0A1U7SWP3_TARSY/23-167  AC A0A1U7SWP3.1
#=GS I3MST8_ICTTR/23-167      AC I3MST8.1
#=GS G1RNX4_NOMLE/23-167      AC G1RNX4.1
#=GS A0A1S2ZY18_ERIEU/23-167  AC A0A1S2ZY18.1
#=GS Q0D250_DANRE/23-166      AC Q0D250.1
#=GS LEP_HORSE/14-133         AC Q9TU09.2
#=GS A0A1V4JHD2_PATFA/1-101   AC A0A1V4JHD2.1
#=GS LEP_SHEEP/2-146          AC Q28603.2
#=GS Q5TYZ1_DANRE/3-108       AC Q5TYZ1.1
#=GS W5NES0_LEPOC/25-172      AC W5NES0.1
#=GS G3WWV6_SARHA/23-167      AC G3WWV6.1
#=GS LEP_MACMU/23-167         AC Q28504.1
#=GS L5KRQ0_PTEAL/2-146       AC L5KRQ0.1
#=GS M7BYR5_CHEMY/25-168      AC M7BYR5.1
#=GS S7MY12_MYOBR/23-167      AC S7MY12.1
#=GS B0KZL0_RABIT/23-167      AC B0KZL0.1
#=GS A0A1U7U3J6_TARSY/1-119   AC A0A1U7U3J6.1
#=GS LEP_HUMAN/23-167         AC P41159.1
#=GS LEP_HUMAN/23-167         DR PDB; 1AX8 A; 3-146;
#=GS G3T647_LOXAF/23-167      AC G3T647.1
#=GS H0WTC0_OTOGA/23-167      AC H0WTC0.1
#=GS A0A1S3FFN8_DIPOR/23-166  AC A0A1S3FFN8.1
#=GS A0A1A6GY44_NEOLE/48-192  AC A0A1A6GY44.1
#=GS A0A2K5HB19_COLAP/23-167  AC A0A2K5HB19.1
#=GS A0A287BKA4_PIG/48-192    AC A0A287BKA4.1
#=GS A0A1U7SPA6_TARSY/23-167  AC A0A1U7SPA6.1
#=GS LEP_PIG/23-167           AC Q29406.1
#=GS M3Y573_MUSPF/23-166      AC M3Y573.1
#=GS F7CFP4_MONDO/23-167      AC F7CFP4.1
#=GS LEP_FELCA/23-167         AC Q9N2C1.1
#=GS A0A2I4DAK8_9TELE/93-198  AC A0A2I4DAK8.1
#=GS H3AP28_LATCH/23-167      AC H3AP28.1
#=GS H3AP27_LATCH/25-169      AC H3AP27.1
#=GS LEP_CANLF/23-167         AC O02720.2
#=GS A0A0D9RCR8_CHLSB/55-199  AC A0A0D9RCR8.1
#=GS G3GZ86_CRIGR/23-167      AC G3GZ86.1
#=GS A0A151MPN9_ALLMI/25-168  AC A0A151MPN9.1
#=GS A0A1U8DFZ0_ALLSI/25-165  AC A0A1U8DFZ0.1
#=GS F1P9L2_CANLF/60-203      AC F1P9L2.2
#=GS W5NER9_LEPOC/25-172      AC W5NER9.1
#=GS LEP_PANTR/2-146          AC O02750.1
#=GS F7AZE4_HORSE/23-167      AC F7AZE4.1
#=GS Q563I5_XENLA/25-169      AC Q563I5.1
#=GS A0A096MW62_PAPAN/23-167  AC A0A096MW62.1
#=GS G1PBQ8_MYOLU/23-139      AC G1PBQ8.1
#=GS A0A1L8GZQ3_XENLA/25-169  AC A0A1L8GZQ3.1
LEP_BOVIN/23-167                    .......................PIRKVQDDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPLLSLSKMDQTLAIYQQILTSLPS..RNV..VQISNDLENLRDLLHLLAASK..SCPLP..QVRALESL.ESLGVVLEASLYSTEVVALSRLQGSLQDMLRQLDLSPGC...
F6PLK2_ORNAN/23-167                 .......................SIEKIQADTKTLTKTIITRIIQLSNR.NGVSTDQRVSG...LD.FIP...GNQQFQNLADMDQTLAVYQQILSSLPM..PDR..TQISNDLENLRSLFALLATLK..NCPFT..RSDGLDTM.EIWGGIVEESLYSTEVVTLDRLRKSLKNIEKQLDHIQGC...
S9WRL3_CAMFR/45-189                 .......................PIQKVQDDTKTLIKTIVTRINDISHT.QLVSSKQRVTG...LD.FIP...GLHPVLSLSKMDQTLAIYQQILTSLPS..RNV..IQISNDLENLRDLLHLLASSK..SCPLP..QARALETL.ESLGSVLEASLYSTEVVALSRLQGSLQDMLQQLDLSLGC...
A0A1S3KQ23_SALSA/91-236             ....................slh---VVRTKVKDLAQTMVIRINKL---.-DISPNL-IEG...MDpFLPaaaVDQHIESLPSIMETMGFYQDLMLFLDW..ADL..KQLVEDTSTMRGLLENWMISRcpGRQQK..QTGEGRLS.EALKDTTRKYGLSVGPVALNRLKGYLGRLLLNLDQLNYC...
A0A1U7QZV4_MESAU/23-167             .......................PIQKVQDDTKTLIKTIVTRINDISHT.QSVSAKQRVTG...LD.FIP...GLHPILTLSKMDQTLAVYQQILTSLPS..RNV..VQISNDLENLRDLLHLLASSK..SCSLP..QTSELQTR.ESLDGVLEASLYSTEVVALSRLQGSLQDILRQLDLSPEC...
L9KXH7_TUPCH/23-167                 .......................PIRKVQDDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPLLSLSKMDQTLAVYQQILTSLPS..RNV..IQISNDLENLRDLLHLLASSK..SCPLP..LASGLDTL.ESLGGVLEASLYSTEVVALSRLQGSLQDMLQQLDLSPRC...
S7NUA4_MYOBR/1-93                   .......................--------------------------.-----------...--.---...----------MDQTLAIYQQILTSLPS..GNV..LQISNDLENLRDLLHLLASSN..SCPFP..RTRSLKTL.EGLDDALEASLYSTEVVVLSRLQGSLQDMLQQLDFSPGC...
B0ZE71_AILME/23-167                 .......................PIRKVQDDTKTLIKTIVTRINDISHT.QAVSSKQRVAG...LD.FIP...GLHPVLSLSRMDQTLAIYQQILTSLHS..RNV..VQISNDLENLRDLLHLLASSK..SCPLP..RARGLESF.ESLGGVLEASLYSTEVVALSRLQAALQDMLQRLDLSPGC...
W5NWK7_SHEEP/61-204                 .......................PIRKVQDDTKTLIKTIVTRINDISHT.-SVSSKQRVTG...LD.FIP...GLHPLLSLSKMDQTLAIYQQILASLPS..RNV..IQISNDLENLRDLLHLLAASK..SCPLP..QVRALESL.ESLGVVLEASLYSTEVVALSRLQGSLQDMLRQLDLSPGC...
G5BHA4_HETGA/23-167                 .......................PIQKVQDDTKTLIKTIVSRINDISHM.QSVSSKHKVTG...LD.FIP...-LYPDLSFSKMDQTLAVYQQIISNLPS.rRNM..VQISNDLDNLQNLVHMLASSK..GCPLP..QTRGPELL.ENLGGALKESIYSTEVVALSRLQRFLQEMLLQLDHNTMC...
LEP_MELGA/2-145                     .....................pc--QIFQDDTKTLIKTIVTRINDISHT.-SVSAKQSVTG...LD.FIP...GLHPILSLSKMDQTLAVYQQVLTSLPS..QNV..LQIANDLENLRDLLHLLAFSK..SCSLP..QTSGLHKP.ESLDGVLEALLYSTEVVALSRLQGSLQDILQQLDISPEC...
A0A2G9RRE5_LITCT/25-169             .....................kt--DRIKADAKLLSRILITRIQEHPIQ.FNYPSSLKSSG...LD.FIP...DEQILESLEKMDETLEIFQKILANIPM..ENV..EQMLSDLENLRSLLQLLNRIM..GCIVT..EPRQTNII.ENLKEQYENASYTMEKVTLDRLQKSLHNIMKHLDYIIDC...
W5LAC9_ASTMX/9-160                  llctitaavvtltacypaittdm--------IRIMARTAVGRIKKIKDEhFQMSPE-----...ID.FGP..nTDTPIEGLTSVLTHLDYLQTRLQVPPA..THL..RQLQTDLETLLGNLERMAVSQ..GCPLP..KPG-----.SNVHKDDTAFPITSNYLYLLELQRYLEKLCLNLDKLKTC...
LEP_RAT/23-167                      .......................PIHKVQDDTKTLIKTIVTRINDISHT.QSVSARQRVTG...LD.FIP...GLHPILSLSKMDQTLAVYQQILTSLPS..QNV..LQIAHDLENLRDLLHLLAFSK..SCSLP..QTRGLQKP.ESLDGVLEASLYSTEVVALSRLQGSLQDILQQLDLSPEC...
F7HGW1_CALJA/23-167                 .......................PIQRVQDDTKTLIKTIIARINDLSHT.QSVSPRQRVTG...LE.FIP...GFHSDLSFSKMDEILATYQQIVISLPS..GNM..IQISNDLENLRALLHLLAASK..SCHLP..WASGLENL.ANLGGVLEVSLYSTEVVALSRLRGTLKDILQQLDLGPAC...
H2QVB5_PANTR/23-167                 .......................PIQKVQDDTKTLIKTIVTRINDISHT.QSVSSKQKVTG...LD.FIP...GLHPILTLSKMDQTLAVYQQILTSMPS..RNM..IQISNDLENLRDLLHVLAFSK..SCHLP..WASGLETL.DSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC...
LEP_GORGO/2-146                     .......................PIQKVQDDTKTLIKTIVTRISDISHT.QSVSSKQKVTG...LD.FIP...GLHPILTLSKMDQTLAVYQQILTSMPS..RNM..IQISNDLENLRDLLHVLAFSK..SCHLP..WASGLETL.DSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC...
LEP_CHICK/20-163                    .....................pc--QIFQDDTKTLIKTIVTRINDISHT.-SVSAKQRVTG...LD.FIP...GLHPILSLSKMDQTLAVYQQVLTSLPS..QNV..LQIANDLENLRDLLHLLAFSK..SCSLP..QTSGLQKP.ESLDGVLEASLYSTEVVALSRLQGSLQDILQQLDISPEC...
L5LF41_MYODS/23-167                 .......................PIQKVQDDTKTLIKTIVTRINDISHT.RSVSSKQRVTG...LD.FIP...GLHPILSLSRMDQTLAIYQQILTSLPS..GNV..LQISNDLENLRDLLHLLASSN..SCPFP..RTRSLKTL.EGLDDALEASLYSTEVVVLSRLQGSLQDMLQQLDFSPGC...
LEP_MOUSE/23-167                    .......................PIQKVQDDTKTLIKTIVTRINDISHT.QSVSAKQRVTG...LD.FIP...GLHPILSLSKMDQTLAVYQQVLTSLPS..QNV..LQIANDLENLRDLLHLLAFSK..SCSLP..QTSGLQKP.ESLDGVLEASLYSTEVVALSRLQGSLQDILQQLDVSPEC...
G8BLB4_BOVIN/23-167                 .......................PICKVQDDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPLLSLSKMDQTLAIYQQILTSLPS..RNV..VQISNDLENLRDLLHLLAASK..SCPLP..QVRALESL.ESLGVVLEASLYSTEVVALSRLQGSLQDMLRQLDLSPGC...
A0A2D0QQV1_ICTPU/25-172             ....................ptd---SMKNSVKLQVENIISRIQKHKDE.FQILHKMILDS...PE.LLPelqSDKPIDGLSSMVDTLNNFQRVLHSLPK..GHM..SQLHSDVSTLQHYLEDRMSSL..QCTHR..KTGTEKNL.EAFLKNHSMYYITLGHITLDRLQKYLQRLNHNLDQLRTC...
A0A286XUJ2_CAVPO/23-165             .......................PMQKLQDDAKFLIKTIINRIRNISHL.QSVSSKHKVTG...FD.FIP...-LSPYLSLPKMDQTLTLYQKVITTLSS..SHT..AQISNDLENLQSLVQMMASSK..GCPLP..HTTEPE-L.QDLESTLKESRYSIEVVVLRRMKRFLLEMLRQLELGIVC...
F7GJN5_MACMU/23-167                 .......................PIQKVQSDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLTLSQMDQTLAVYQQILINLPS..RNV..IQISNDLENLRDLLHLLAFSK..SCHLP..LASGLETL.ESLGDVLEASLYSTEVVALSRLQGSLQDMLWQLDLSPGC...
H2PNF0_PONAB/23-167                 .......................PIQKVQDDTKTLIKTVITRINDISHT.QSVSSKQKVTG...LD.FIP...GLHPILTLSKMDQTLAVYQQILTSMPS..RNV..IQISNDLENLRDLLHVLAFSK..SCHLP..WASGLETL.DRLGGVLEASGYSTEVVALSRLQRSLQDMLWQLDLSPGC...
G3QF76_GORGO/23-167                 .......................PIQKVQDDTKTLIKTIVTRISDISHT.QSVSSKQKVTG...LD.FIP...GLHPILTLSKMDQTLAVYQQILTSMPS..RNM..IQISNDLENLRDLLHVLAFSK..SCHLP..WASGLETL.DSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC...
A0A2K5LMB9_CERAT/23-167             .......................PIQKVQSDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLTLSQMDQTLAIYQQILINLPS..RNV..IQISNDLENLRDLLHLLAFSK..SCHLP..LASGLETL.ESLGDVLEASLYSTEVVALSRLQGSLQDMLWQLDLSPGC...
G7P0L3_MACFA/23-167                 .......................PIQKVQSDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLTLSQMDQTLAIYQQILINLPS..RNV..IQISNDLENLRDLLHLLAFSK..SCHLP..LASGLETL.ESLGDVLEASLYSTEVVALSRLQGSLQDMLWQLDLSPGC...
E9Q7Z0_MOUSE/23-98                  .......................PIQKVQDDTKTLIKTIVTRINDISHT.QSVSAKQRVTG...LD.FIP...GLHPILSLSKMDQTLAVYQQVLTSLPS..QNV..LQI------------------..-----..--------.---------------------------------------a..
A0A091E2N1_FUKDA/90-234             .......................PIQKVHDDTKILIKTIVSRINEISHM.QSVSSKHKVTG...LD.FIP...-FYPDLSFSKMDQTLAVYQQIIINLSS.rRTM..VQISNDLDNLRNLVHMLASFR..GCPVP..QTRGPDLL.ENLGGAFKESIYSTEVVALSRLQRFLQEMLLQLDHSTMC...
A0A1U7SWP3_TARSY/23-167             .......................PIHRVQDDSRDLIKTIVTRINDTSHT.QSVSSLQRIAG...LD.FIP...GLQPVLSLSKMDETLAVYQQILTRLPP..RNV..VQILNDLENLRDLLYLLAVSK..GCPFP..HSSGLKTL.ESLDGVLEASRYSMEVVTLSRLQASLQDMLQQLDLGPRC...
I3MST8_ICTTR/23-167                 .......................PIRKVQDDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLSLSKMDQTLAVYQQILTSLPS..QNV..MQISNDLENLRDLLRLLASSK..SCPLP..QTSGLETL.ESLDGVLEASLYSTEVVALSRLQGSLQGMLRQLDFSPRC...
G1RNX4_NOMLE/23-167                 .......................PIQKVQDDTKTLIKTIVTRINDISHM.QSVSSKQKVTG...LD.FIP...GLHPVLTLSKMDQILAVYQQILTSLPS..RNV..IQISNDLENLRDLLHVLAFSK..SCHLP..WASGMETL.ASLGGVLEASGYSMEVVALSRLQGSLQDMLWQLDLSPGC...
A0A1S2ZY18_ERIEU/23-167             .......................PIERIQDDTKTLIKTTILRINSMSHK.QPTTFRHRVSG...LD.FIP...ELQPEPSFSSMEQTLSIYQQILTNLLS..RNG..VQVINDLENLRELLHLQSSSK..GCPKP..QASHSESL.GKLEEDLESSLFSMEVVTLGKLREVLQNMLQQLELHPGC...
Q0D250_DANRE/23-166                 .................vhqhdr------KNVKLQAKTIIVRIREHIDG.QNLLPTLIIGDpghYP.EIP...ADKPIQGLGSIMETINTFHKVLQKLPN..KHV..DQIRRDLSTLLGYLE----GM..DCTLK..ESTNGKAL.DAFLEDSASYPFTLEYMTLNRLKQFMQKLIDNLDQLKIC...
LEP_HORSE/14-133                    .......................PIRKVQDDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLSLSKMDQTLAIYQQILTSLPS..RNV..IQISNDLENLRDLLHLLASSK..SCPLP..QARGLETL.ASLGGVLEASL----------------------------llh
A0A1V4JHD2_PATFA/1-101              .....................mg--------------------------.-----------...--.---...-------LGALAQRLPPLQRLLGSLAPghPPL..AQVANDTENLRSLLLTLVTLL..GCPLP..AVSPPPGVpPRLAELVAEAPHTVAAVALARLRDCVDAIATRLDGPPAC...
LEP_SHEEP/2-146                     .......................PIRKVQDDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPLLSLSKMDQTLAIYQQILASLPS..RNV..IQISNDLENLRDLLHLLAASK..SCPLP..QVRALESL.ESLGVVLEASLYSTEVVALSRLQGSLQDMLRQLDLSPGC...
Q5TYZ1_DANRE/3-108                  ....................pei--------------------------.-----------...-D.FGP..dIDNPIDGLSSVLSYLSYLQLRLHVPPA..QHL..QQVQIDLETLLRTLEELAVSQ..GCPLP..NPETPV--.---HKEETAFPVTSNYLHLLELQRFLEKLCLNIDKLKYC...
W5NES0_LEPOC/25-172                 .....................ae--DRVKNDARLLAQTTVIRIQKHTNE.SKMSPNLVFSG...LE.LIPdalNDKTLEGLSTVEDNLHTFQEILSSLPM..EEM..DQILADIFNLRMIIKSLATSV..NCAPL..KSSNMSHL.ESFLKTNAAFHVTIGNVALERLQKYLLKLIRNLDQLKNC...
G3WWV6_SARHA/23-167                 .......................PIRKVQDDTKTLTKTIITRINDISHM.YSISAKQRVTG...LD.FIP...GLHPFQSLSDMDQTLAIYQQILSNLSS..RNM..VQISNDLENLRDLLHLLGSLK..SCPFD..EADGLSAL.GNLEGVMEASLYSTEVVTLSRLQKSLYGMLQQLDLIHGC...
LEP_MACMU/23-167                    .......................PIQKVQSDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLTLSQMDQTLAIYQQILINLPS..RNV..IQISNDLENLRDLLHLLAFSK..SCHLP..LASGLETL.ESLGDVLEASLYSTEVVALSRLQGSLQDMLWQLDLSPGC...
L5KRQ0_PTEAL/2-146                  .......................PIRKVQDDTKILIKTIVTRINDISHT.QSVSSKQKVTG...LD.FIP...RLHTALTLSKMDQTLAIYQQILTTLSS..RNV..IQISNDLENLRDLLHLLASFR..SCPFP..RASSPKTL.KGLGDVLETSFYSTEVVALSRLQGFLQDMLQQLDFSPGC...
M7BYR5_CHEMY/25-168                 ......................k-IDKVKADTKNLTRTIIARIQEH---.QLFPLNLKING...LD.FIP...GERPLESLDSMDETLQIFQRILPSLPM..ENVpvAQIFNDIENLRSLIQTLGSHL..GCTFH..KSSTLDAL.GNLTELLTTSPYTAAVVALDRLQKCLHSIIKHLDHIQRC...
S7MY12_MYOBR/23-167                 .......................PIQKVQDDTKTLIKTIVTRINDISHT.RSVSSKQRVTG...LD.FIP...GLHPILSLSRMDQTLAIYQQILTSLPS..GNV..LQISNDLENLRDLLHLLASSN..SCPFP..RTRSLKTL.EGLDDALEASLYSTEVVVLSRLQGSLQDMLQQLDFSPGC...
B0KZL0_RABIT/23-167                 .......................PMRKVQDDTKTLIKTIVTRISDISHT.QSVSSRQRVVG...LD.FIP...GLHPNLSLSTMDQTLAIYQQILASLPS..RNV..IQIANDLENLRDLLHLLASSK..SCPLP..RASGLETL.EGLGGVLEASLYSTEVVALSRLQGFLQAMLQQLDLGPGC...
A0A1U7U3J6_TARSY/1-119              .......................--------------------------.QSVSSLQRIAG...LD.FIP...GLQPVLSLSKMDETLAVYQQILTRLPP..RNV..VQILNDLENLRDLLYLLAVSK..GCPFP..HSSGLKTL.ESLDGVLEASRYSMEVVTLSRLQASLQDMLQQLDLGPRC...
LEP_HUMAN/23-167                    .......................PIQKVQDDTKTLIKTIVTRINDISHT.QSVSSKQKVTG...LD.FIP...GLHPILTLSKMDQTLAVYQQILTSMPS..RNV..IQISNDLENLRDLLHVLAFSK..SCHLP..WASGLETL.DSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC...
#=GR LEP_HUMAN/23-167         SS    .......................X-HHHHHHHHHHHHHHHHHHHH----.-----------...--.S--...-SS--SSHHHHHHHHHHHHHHHHTS--..HHH..HHHHHHHHHHHHHHHHHHHHT..T----..-----S-G.GGGHHHH-BTTB-HHHHHHHHHHHHHHHHHHHGGG----...
G3T647_LOXAF/23-167                 .......................PIRKVQDDTKTLIKTIVTRISDISHT.QSVSSKHRVTG...LD.FIP...GLHPVLNLSKMDQTLAIYQQILTSLPS..RNV..IQIANDLENLRDLLHLLAASK..SCPFP..RASGLETL.ESLGGVLEASLYSTEVVALSRLQGSLQDMLRQLDLSPGC...
H0WTC0_OTOGA/23-167                 .......................PIQKVQDDTKTLIKTIVTRISDISHT.QLVSSKQRVTG...LD.FIP...AVHPVLSLSKMDQTLAVYQQILTSLPS..RNV..IQISNDLENLRDLLHLLASSK..NCPLP..WTSGLETL.ANLGSVLEASLYSTEVVALSRLQGSLQDMLRQLDLSPGC...
A0A1S3FFN8_DIPOR/23-166             .......................PVQKVQDDAKSLIKTIIIRINDISHM.-PLSSRQKITG...LD.FIP...GLFPALSLSKMDHTLAVHQQILTRLYS..QNA..MQISNDLENLRALLQLLASFK..NCPQP..QMSNMKIL.ESLISVEEAFRHSTEVVALSRLQGSLKNILKQLDLNPGC...
A0A1A6GY44_NEOLE/48-192             .......................PIQKVQDDTKTLIKTIVTRINDISHT.QSVSAKQRVTG...LD.FIP...GLHPILSLSKMEQTLAIYQQILSSLPS..RNV..VQISNDLENLRDLLHLLASSK..SCSLP..QTSDLQKL.ESLDGVLEASLYSTEVVALSRLQGSLQDILRQLDLSPEC...
A0A2K5HB19_COLAP/23-167             .......................PIQKVQSDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLTLSQMDQTLAIYQQILINLTS..RNV..IQISNDLENLRGLLHLLAFSK..SCHLP..LAGGLETL.ESLGGVLEASLYSTEVVALSRLQRSLQDMLWQLDLSPGC...
A0A287BKA4_PIG/48-192               .......................PIWRVQDDTKTLIKTIVTRISDISHM.QSVSSKQRVTG...LD.FIP...GLHPVLSLSKMDQTLAIYQQILTSLPS..RNV..IQISNDLENLRDLLHLLASSK..SCPLP..QARALETL.ESLGGVLEASLYSTEVVALSRLQGALQDMLRQLDLSPGC...
A0A1U7SPA6_TARSY/23-167             .......................PIHRVRDDSRALIKTIVTRINDISHT.QSVSSLQRIAG...LD.FIP...GLQPVLSLSKMDETLAVYQQILTRLPP..RNV..VQILNDLENLRDLLYLLAVSK..GCPFP..HSSGLKTL.ESLDGVLEASRYSMEVVTLSRLQASLQDMLQQLDLGPRC...
LEP_PIG/23-167                      .......................PIWRVQDDTKTLIKTIVTRISDISHM.QSVSSKQRVTG...LD.FIP...GLHPVLSLSKMDQTLAIYQQILTSLPS..RNV..IQISNDLENLRDLLHLLASSK..SCPLP..QARALETL.ESLGGVLEASLYSTEVVALSRLQGALQDMLRQLDLSPGC...
M3Y573_MUSPF/23-166                 .......................PIRKVQDDTKTLIKTIVTRISDISHT.-AVSSKQRVAG...LD.FIP...GLHPVLSLSRMDQTLAIYQQILTSLHS..RNV..IQISNDLENLRDLLRLLASSK..SCPLP..RARGLESF.ESLGGILEASLYSTEVVALSRLQAALQDMLGRLDLSPGC...
F7CFP4_MONDO/23-167                 .......................PIRKVQDDTKTLTKTIITRINDISHM.YSISAKQRVTG...LD.FIP...GLHPFQSLSDMDQTLAIYQQILSNLSS..RNM..VQISNDLENLRDLLHLLGSLK..SCPFD..EADGLSSL.GNLEGVMEASLYSTEVVTLTRLQKSLYGMLQQLDLIHGC...
LEP_FELCA/23-167                    .......................PIRKVQDDTKTLIKTIVTRINDISHT.QSVSSKQRVAG...LD.FIP...GLHPVLSLSKMDQTLAIYQQILTGLPS..RNV..VQISNDLENLRDLLHLLASSK..NCPLP..RARGLETL.ESLGGALEASLYSTEVVALSRLQASLQDMLWRLDLSPGC...
A0A2I4DAK8_9TELE/93-198             .................tlrpsi--------------------------.-----------...--.---...--TELGGLFSIVAVLEGYNNLISD-SL..ENV..TQIKTEISILTEYIHQWS-LE..HCKELqtKSPEPEAL.KSLQK-LKRFIHTVGIEALMRVKEYLELLRNNLDHLEIC...
H3AP28_LATCH/23-167                 ..psnrikpwektignqqsntll---------------------GLSSQ.FLLPLNLKVSG...LE.FIP...AERPLESLGSMDETLEIFHWILSSLPV..DDV..TQILWDIENLRALLQTLATTM..GCELH..QTTELETL.KDLAKEHSTSPYTTEKVALDRLQKCLLTMVKELEQIKDC...
H3AP27_LATCH/25-169                 ......................k-IEKVKSDARNLTRIIITRIQQHPNQ.FLLPLNLKVSG...LE.FIP...AERPLESLGSMDETLEIFHWILSSLPV..DDV..TQILWDIENLRALLQTLATTM..GCELH..QTTELETL.KDLAKEHSTSPYTTEKVALDRLQKCLLTMVKELEQIKDC...
LEP_CANLF/23-167                    .......................PIRKVQDDTKTLIKTIVARINDISHT.QSVSSKQRVAG...LD.FIP...GLQPVLSLSRMDQTLAIYQQILNSLHS..RNV..VQISNDLENLRDLLHLLASSK..SCPLP..RARGLETF.ESLGGVLEASLYSTEVVALNRLQAALQDMLRRLDLSPGC...
A0A0D9RCR8_CHLSB/55-199             .......................PIQKVQSDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPILTLSQMDQTLAIYQQILINLPS..RNV..IQISNDLENLRDLLHLLAFSK..SCHLP..WASGLETL.ESLGGVLEASLYSTEVVALSRLQGSLQDMLWQLDLSPGC...
G3GZ86_CRIGR/23-167                 .......................PIQKVQDDTKTLIKTIVTRINDISHT.QSVSAKQRVTG...LD.FIP...GLHPILSLSKMDQTLAVYQQILTSLPS..RNV..VQISNDLENLRDLLHLLASSK..SCSLP..PTSELQQL.ESLDGVLEASLYSTEVVALSRLQGSLQDILQQLDLSPEC...
A0A151MPN9_ALLMI/25-168             ......................k-IDKVKADAKNLTRTLIARIQEL---.QLLPVNLKVSG...LD.FLP...GERPPESLEAMDATLQVFQRVLAGLPL..DAVpgAQLANDMENLRSLLRLLGAHL..GCAPP..AAPAAPAL.GNLTDLLAEAPYSAAAVALDRLHKSLHGITKHLDQLRCC...
A0A1U8DFZ0_ALLSI/25-165             ......................k-IDKVKADAKNLTRTLIARIQEL---.QLLPVNLKVSG...LD.FLP...GERPLESLEAMDATLQVFQRVLAGLPL..DAVpgAQLANDMENLRSLLRLLGAHL..GCAPP..AAPALG--.-NLTDLLAEAPYSAAAVALDRLHKSLHGITKHLDQLRCC...
F1P9L2_CANLF/60-203                 .......................PIRKVQDDTKTLIKTIVARINDISHT.-SVSSKQRVAG...LD.FIP...GLQPVLSLSRMDQTLAIYQQILNSLHS..RNV..VQISNDLENLRDLLHLLASSK..SCPLP..RARGLETF.ESLGGVLEASLYSTEVVALSRLQAALQDMLRRLDLSPGC...
W5NER9_LEPOC/25-172                 .....................ae--DRVKNDARLLAQTTVIRIQKHTNE.SKMSPNLVFSG...LE.LIPdalNDKTLEGLSTVEDNLHTFQEILSSLPM..EEM..DQILADIFNLRMIIKSLATSV..NCAPL..KSSNMSHL.ESFLKTNAAFHVTIGNVALERLQKYLLKLIRNLDQLKNC...
LEP_PANTR/2-146                     .......................PIQKVQDDTKTLIKTIVTRINDISHT.QSVSSKQKVTG...LD.FIP...GLHPILTLSKMDQTLAVYQQILTSMPS..RNM..IQISNDLENLRDLLHVLAFSK..SCHLP..WASGLETL.DSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC...
F7AZE4_HORSE/23-167                 .......................PIRKVQDDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLSLSKMDQTLAIYQQILTSLPS..RNV..IQISNDLENLRDLLHLLASSK..SCPLP..QARGLETL.ASLGGVLEASLYSTEVVALSRLQGSLQDMLQQLDLSPGC...
Q563I5_XENLA/25-169                 .....................ka--DRVKNDAKLLASTLITRIQEHPIQ.FLFPSNLKISG...LD.FIP...DEQLLESLEHMDETLEVFQKILSSLPM..ENV..DQMLSDMENLRSLLQSLSTIM..GCTAR..KHSQCDTQ.VNLTEEYAKAPYTTEKVALDRLQKSLHSIVKHLDHITDC...
A0A096MW62_PAPAN/23-167             .......................PIQKVQSDTKTLIKTIVTRINDISHT.QSVSSKQRVTG...LD.FIP...GLHPVLTLSQMDQTLAIYQQILINLPS..RKV..IQISNDLENLRDLLHLLAFSK..SCHLP..LASGLETL.ESLGDVLEASLYSTEVVALSRLQGSLQDMLWQLDLSPGC...
G1PBQ8_MYOLU/23-139                 .......................PIQKVQDDTKTLIKTIVTRINDISHT.RSVSSRQRVTG...LD.FIP...GLHPILSLSRMDQTLAIYQQILTSLPS..GNV..LQISNDLENLRDLLHLLASSN..SCPFP..RTRSLKTL.EGLDDALEAS-----------------------------l..
A0A1L8GZQ3_XENLA/25-169             .....................kt--DRVKNDAKMLARTLITRIQEHPIQ.YLFPSNLKISG...LD.FIP...DEQLLESLEHMDETLEVFQEILSSLPM..ENV..DQMLSDMENLRSLLQLLSTIM..GCTTR..KHSQSDTQ.VNLTEEYAKAPYTTEKVALDRLQKSLHSIVKHLDHITNC...
#=GC SS_cons                        .......................X-HHHHHHHHHHHHHHHHHHHH----.-----------...--.S--...-SS--SSHHHHHHHHHHHHHHHHTS--..HHH..HHHHHHHHHHHHHHHHHHHHT..T----..-----S-G.GGGHHHH-BTTB-HHHHHHHHHHHHHHHHHHHGGG----...
#=GC seq_cons                       .......................PIpKVQDDTKTLIKTIVTRINDISHT.QSVSSKQ+VTG...LD.FIP...GLHPlLSLS+MDQTLAlYQQILoSLPS..+NV..lQISNDLENLRDLLHLLAsSK..SCsLP..pssuL-oL.EuLssVLEAShYSTEVVALSRLQuSLQDMLpQLDluPsC...
//
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