GenomeNet

Database: Pfam
Entry: LmjF365940-deam
LinkDB: LmjF365940-deam
Original site: LmjF365940-deam 
#=GF ID   LmjF365940-deam
#=GF AC   PF14421.7
#=GF DE   A distinct subfamily of CDD/CDA-like deaminases
#=GF PI   CDD_CDA_1;
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF SE   Manual
#=GF GA   45.70 45.70;
#=GF TC   115.40 46.50;
#=GF NC   32.00 28.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   21890906
#=GF RT   Evolution of the deaminase fold and multiple origins of
#=GF RT   eukaryotic editing and mutagenic nucleic acid deaminases from
#=GF RT   bacterial toxin systems.
#=GF RA   Iyer LM, Zhang D, Rogozin IB, Aravind L;
#=GF RL   Nucleic Acids Res. 2011; [Epub ahead of print]
#=GF DR   INTERPRO; IPR032723;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A distinct branch of the CDD/CDA-like deaminases prototyped by 
#=GF CC   Leishmania LmjF36.5940. Members of this family are widely
#=GF CC   distributed across several microbial eukaryotes such as
#=GF CC   kinetoplastids,  chlorophyte algae, stramenopiles and the
#=GF CC   alveolate Perkinsus. Domain  architectures suggest that these
#=GF CC   proteins might possess mRNA editing  or DNA mutagenizing
#=GF CC   activity [1].
#=GF SQ   46
#=GS A0A0N7L3D3_PLAHL/339-619  AC A0A0N7L3D3.1
#=GS A0A0G4GFE1_VITBC/163-209  AC A0A0G4GFE1.1
#=GS W2KJB1_PHYPR/372-637      AC W2KJB1.1
#=GS D0N437_PHYIT/361-620      AC D0N437.1
#=GS A0A3M6VVK1_9STRA/352-645  AC A0A3M6VVK1.1
#=GS C1EFE8_MICCC/391-596      AC C1EFE8.1
#=GS D7G3E7_ECTSI/557-885      AC D7G3E7.1
#=GS T0RET2_SAPDV/307-526      AC T0RET2.1
#=GS W4FWW5_9STRA/333-560      AC W4FWW5.1
#=GS A0A3R7G344_9STRA/354-598  AC A0A3R7G344.1
#=GS C1N795_MICPC/486-700      AC C1N795.1
#=GS A4HQB2_LEIBR/418-544      AC A4HQB2.1
#=GS A0A1X0NLM5_9TRYP/378-501  AC A0A1X0NLM5.1
#=GS Q4Q0G6_LEIMA/412-537      AC Q4Q0G6.1
#=GS A0A0G4GFE1_VITBC/70-165   AC A0A0G4GFE1.1
#=GS A0A024TN09_9STRA/318-550  AC A0A024TN09.1
#=GS A4HQB2_LEIBR/540-610      AC A4HQB2.1
#=GS A0A1V9ZMX0_9STRA/308-518  AC A0A1V9ZMX0.1
#=GS A0A225VY69_9STRA/350-624  AC A0A225VY69.1
#=GS A0A067CZ46_SAPPC/307-527  AC A0A067CZ46.1
#=GS A0A329SQ63_9STRA/361-647  AC A0A329SQ63.1
#=GS Q4CXE8_TRYCC/489-561      AC Q4CXE8.1
#=GS A0A0L0FHB9_9EUKA/30-302   AC A0A0L0FHB9.1
#=GS M4BQJ0_HYAAE/354-656      AC M4BQJ0.1
#=GS A4IE07_LEIIN/127-253      AC A4IE07.1
#=GS Q38A89_TRYB2/370-496      AC Q38A89.1
#=GS A0A024GRI2_9STRA/349-596  AC A0A024GRI2.1
#=GS A4IE07_LEIIN/250-318      AC A4IE07.1
#=GS Q4CXE8_TRYCC/369-492      AC Q4CXE8.1
#=GS B7GB54_PHATC/685-977      AC B7GB54.1
#=GS Q4DNI7_TRYCC/489-561      AC Q4DNI7.1
#=GS G5AGH2_PHYSP/357-655      AC G5AGH2.1
#=GS A0A0G4ECT7_VITBC/341-386  AC A0A0G4ECT7.1
#=GS A0A0W8CV57_PHYNI/361-629  AC A0A0W8CV57.1
#=GS A0A0G4ECT7_VITBC/249-344  AC A0A0G4ECT7.1
#=GS A0A0G4IVG2_PLABS/332-537  AC A0A0G4IVG2.1
#=GS Q4DNI7_TRYCC/369-492      AC Q4DNI7.1
#=GS A0A1V9Z9N5_9STRA/301-522  AC A0A1V9Z9N5.1
#=GS A0A0G4EQ48_VITBC/40-132   AC A0A0G4EQ48.1
#=GS A0A1X0NLM5_9TRYP/499-570  AC A0A1X0NLM5.1
#=GS Q38A89_TRYB2/493-566      AC Q38A89.1
#=GS W4FZ70_9STRA/317-544      AC W4FZ70.1
#=GS H3GUA2_PHYRM/361-650      AC H3GUA2.1
#=GS A0A0G4EQ48_VITBC/131-176  AC A0A0G4EQ48.1
#=GS Q4Q0G6_LEIMA/534-603      AC Q4Q0G6.1
#=GS W2PRR7_PHYPN/372-640      AC W2PRR7.1
A0A0N7L3D3_PLAHL/339-619             .................a-MTQMIVNEMQQFRDQFLEAEGQ---GEVAGFWLRKS.RKPVLAVLL..IEKP..--AIDGG.RPTIV...............................MQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGLNL..TA....GGNTSPTT.....SDDRV...QDTHTIA.eTIET....TDSA......................TTNrtvdttkaqisavqtcrsh...................................seqssfssvltvnstflsiQ--Narqhddvai....................................ekergqtrrKRQL.........................................RITN.ANL.........RSPRKPkrprtfsfddmaviemmrasePLDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVITFENA.RCRNVYINQL-m..
A0A0G4GFE1_VITBC/163-209             ................va-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........----DP.....................KDEL...NP.IAPCGVCDEWLQKIQE.....ESPGFSIVTFTTS.ECNEI------rer
W2KJB1_PHYPR/372-637                 .................a-MTQMIVREMRKFRDQFLAAEGE---GEVAGFWLRKS.RKPVLAVLL..IEKP..-AAELGG.RPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGLNLtaGG....NISVTSPT.....ASEDT...ADDKKEP.sDGAT....FDKK......................TSTa......................................................................vePANSqvlpvrvrpaavqssrss..................aavnnlsvddagrgrgrgKRAL.........................................ETKN.ANL.........TSPRKPkrprtfsfdevaveemmrasaPPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYIN---...
D0N437_PHYIT/361-620                 .................a-LTQMIVREMRKFRDQFLAAEGE---GEVAGFWLRKS.RKPVLAVLL..IEKP..-AAELGG.RPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL--..--....--NLTAGG....nSSSVT...SPTASED..T---....GDDA.....................kRKEpsqgasfdktasts............................................tapaelhvveaanpqV--Lsvrvrpaavqsslssaat..................nnstvaaragrgrgrgrgKREL.........................................ETKN.ANL.........TSPRKP.....................K---...RPrTFSFDEVAEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQIM...
A0A3M6VVK1_9STRA/352-645             .................a-MTQMVVREMRMFRDQFLSAEGE---GEVASFWLRKS.RKPVLAVLL..IEKP..-ATVAGE.RPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGLNLaaDD....IVSPSPSKytkhhNATQD...DDKKKKRkpSQVQ....----......................--Agatldettstasepgs........................................iatllqsvglqlpvqirPTSVqcsskvdkaliptdetvq..................hsangtgqgqgcgnrgreE--M.........................................NVNL.VSS.........RKPKRPrtfsfdkva...meemirgstPLDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYISQI-i..
C1EFE8_MICCC/391-596                 .................r-LVTGMVQEMKKHRDVFLSMSHSK--HELGEFWLRKT.QKPVLAVLC..VRRRrdGPDDAAHgDAKPQ...............................YFRGVNLEVSMPTGSLCSERNAIGNALASDPALRRKDLFGIAVLSLGK..GD....IGATSGGGv...gGGAMS...RESSFVN.lAQLA....AGNG......................GDD.........................................................................-LSL......................................................CRPV.........................................TGGG.G--.........-----G.....................RGDL...NP.LKPCGACKEWLLKIAE.....VNPGFKVLMFGDV.SCDDVYIKNV-s..
D7G3E7_ECTSI/557-885                 ..................AYTRQAFDAPAG-DANGEAVVGGDTRDDLASFWLRKT.KKPVLAVLL..VQKK..-------.GGRPQ...............................LFRGTNMEVSMPTGSLCAERNVIGSALTSDLSLLRRDIKAVAVLSVAH.lGG....PPASTATT.....AAAVP...IDERKEG..ASLTgitaVDSG......................GGRsgwpgaagmgsavgssl......................................ttscapsplsltpamkvsPKSAllrtetgagaedke..........................rlegvrqvrrktkvV--RsiastpkrgvgsggiaaggwekspltdsgggggggrgdgggGMYS.DDQgggggsnhhRHPRTSrssi.............vahvPPETlcsNP.LKPCGACMEWLKKIAE.....VNPDFKVITFTDS.RCGGVYIEDV-a..
T0RET2_SAPDV/307-526                 ..............plvl----RLVDEMKAFRDCFVDGQH---LGEVGSFWLRKS.RKPVLAILL..IQKT..---LPNG.ETALV...............................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLHRNALKMIGVLSV--..-N....LAPSSSTTal.plPRTVS...LPTPIMP..TVRA....AADCsspkakkp.....krprtfscdGTT.........................................................................PAVA......................................................SALA.........................................EISA.P--.........---KKEv..................paPEDR...NP.LGPCGACNEWLLKIAE.....ANPSFKIITFGSM.ECDSIYVHQ--ll.
W4FWW5_9STRA/333-560                 .................p-LVARAVDEIKAFRDQFVQGEHL---GEVGQFWLRKS.RKPVLAVLL..VEKR..---TSSG.DVQVV...............................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLLRQSLKMIAVLSVSLhpLKlappPPPSLSST.....SLLLP...APPALIL..AHATt.ttVTTAvea...............spktGRK.........................................................................PKRP......................................................-RTIscdas..............................vpsiqaALDA.VDA.........SAAT--.....................EKDL...NP.LAPCGACNEWLLKIAE.....ANPSFKIVTFDSI.DCDSVYIHQ--ll.
A0A3R7G344_9STRA/354-598             .................t-MTQKVVHEMRLFRDQFLAAEHE---GEVASFWLRKS.RKPVLAVLL..IEKP..-ATVAGE.QPTII...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRSLKMIAVLGLNL..AE....FATSTSNE.....--VLP...IRIHLGS.aGSIQ....SASAatktepqvp...sipiprvnggG-Gtgrgkrass.......................................................enknanllsP---......................................................----.........................................----.---.........---RKPkrprtfsfdeaaveqmvragsAPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYIKQL-m..
C1N795_MICPC/486-700                 ..................AIISRMVDEMKKHRDAYVAAASEK-TNELGAFWLRKT.RKPVLAVLC..VRKK..GKTGRGH.----E...............................FYRGVNLEVSMPTGSLCSERNVIGTALACDPTLRRADLFGVAVLSLKK.tGG....EGSGSGNAq...kGGVINggvRDGGTAP.pTPVP...gSSFA......................GGA.........................................................................SRNA......................................................SYAN.........................................DLSG.LGS.........GPTCRPv...................aEDDL...NP.LHPCGACKEWLYKIAE.....VNPGFKVVMFTDA.SCEEVFVKTV-g..
A4HQB2_LEIBR/418-544                 .................n-IIDLKKEHPNSFFSNATRMIQHFCRTRAHCSWRKHDpTRPVVTSVLtfVDVN.rCHCHRNG.DNPYNtheehieasfpsdie.amgtpsgawcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------lgv
A0A1X0NLM5_9TRYP/378-501             .................d-VIDLKKEKEGSFLSFVTPIILSFRHENAHVSWRKKDpQRPVVTSLItyVDPA.eCSCRSNE.GFLSRgsfvrhhlpqkgt....ekypenswcscprsFVIAVNYELSTPSGSRCSEQNAMGK-LAS-------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------mgl
Q4Q0G6_LEIMA/412-537                 .................t-IIDLKKEQPNTFFSNATRIIQNFCRTHAHCSWRKHNpSRLVVTSVLtfVDVN.kCHCHLNG.DNPEDthderidapitadie.amgtpsgswcqcmrgGVIAVNYELSTPSGSRCSEQNAMGK-LAS-------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------lg.
A0A0G4GFE1_VITBC/70-165              ...............plk----RLVDEMRRFVNDWKSFEAA---GEMDPFWHRKS.SKTVLAVVM..VVNK..-------.SGQEM...............................FYRGMNSEISLPSGSNCAERSAISTCISNSLDVRRSDFRAIAV-----..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------ad.
A0A024TN09_9STRA/318-550             .................p-IVTRLVNEVKSFRDQFVQGEHL---GEVGQFWLRKS.RKPVLAVLL..IEKL..----VDG.TPTIV...............................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLLRQSLKMIAVLSVTL..HS....HPKQVAMA.....SAAQP..pCSSTA--..--LP....IDAPppvlvnvpssiqpsnverspkaGRK.........................................................................PKRP......................................................-RTIscdas..............................vpaiqaALTAvDAA.........TAMAKA.....................EKDL...NP.LAPCGACNEWLLKIAE.....ANPSFKIVTFDSI.DCDSVYIHQ--ll.
A4HQB2_LEIBR/540-610                 ..............aslg-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................--V.........................................................................PTWG......................................................VREV.........................................FVHG.M--.........ASKKEA.....................----...NP.LFPCGVCENMLQRVTKdvlahYGGDITLYMFDAT.TPRKIVFLPI-p..
A0A1V9ZMX0_9STRA/308-518             ..............fllr-----LVSEMKAFRDCFLEGQH---LGEVGSFWLRKS.RKPVLAILL..IQKK..---LPNG.DITTV...............................VHRGMNCEVSMPTGSLCAERNAIGSALASDPTLHRNALKMIGVLSVNL.aPP....SPPQTELM.....PPQI-...TPSVHSN..GSD-....----......................SSS.........................................................................PKSKkpkrpr.........................................tfscdgtTPAV.........................................ALAL.DSI.........SNPKKE.....................AVDR...NP.LGPCGACNEWLLKIAE.....ANPSFKIITFGSM.ECDSIYVHQ--ll.
A0A225VY69_9STRA/350-624             .................a-MTQMIVREMRMFRDQFLAAEGE---GEVASFWLRKS.RKPVLAVLL..IEKP..-AAVAGE.RPTVV...............................VQRGLNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL--..--....--NLSASG.....TSSIT...SPTASER..DEVT....GDGGk...................tnEAG.........................................................................PTTDkttststdhdlatsspqklparvrp...apvqisqtqraasvdgagrgqgrgrgKRES.........................................EAKN.ANL.........TSPRKPkrprtfsfdemaveemvrasgPPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m..
A0A067CZ46_SAPPC/307-527             .................p-LVQRLVDEMKSFRDCFVDGQH---LGEVGSFWLRKS.RKPVLAILL..IQKT..---LPTG.ETALV...............................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLHRNALKMIGVLSVNL..--....--APPSTS.....TSSLP...LPRTVSL.pTPITptvrAATDcsspkakkp....krprtfscdGTT.........................................................................PAVA......................................................SALA.........................................EISA.---.........--PKKEv..................paPEDR...NP.LGPCGACNEWLLKIAE.....ANPSFKIITFGSM.ECDSIYVHQ--ll.
A0A329SQ63_9STRA/361-647             .................a-LTQMIVREMRKFRDQFLSAEGE---GEVAGFWLRKS.RKPVLAVLL..IEKP..-AADIGG.RPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGL--..--....--NLTAGG....aGSSVT...SPTASED..T---....GDDA......................KKKepshgatfdkatststa......................................taelvgpanpqvlpvrvrPASVqsslssaavnhstpaq.....................rradavgtgrgrgrgrgKREL.........................................ETKN.ANL.........TSPRKPkrprtfsfdevaveemmrasaPPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m..
Q4CXE8_TRYCC/489-561                 ..............smgl-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................---.........................................................................PTSA......................................................IREI.........................................FVHG.EML.........GSKKDP.....................----...NP.LFPCGVCENMLRKVTRdvhdtYGGDVVLYMFDSTvNPKKLVYLPIN...
A0A0L0FHB9_9EUKA/30-302              .....csvaretfqpwpc------------------HIVED-GDSEINEFWLRKT.KKPVLSVLR..YTKP..-------.GEESQ...............................YVYGMNIEVSMPTGSLCSERNAIGTAIASDPSLKRKDFDMIAILSISL..PE....LANASTP-.....-AVTP...NPARRDRrsTELD....TNQT......................DTNqtqtslttehgmlkgskgsah..............................tlanvlsdvaqnagptttdgtkS--Aatskppgsqplmnavpp....................rgfyedclaplkrfnsdLQAL.........................................TIGN.EEFi.......wP--QEK....................kRTEL...NP.LDPCGSCMEWLRKIAE.....VNPDMKIVTFDSS.SCERLYVKNV-i..
M4BQJ0_HYAAE/354-656                 .................a-MTQRIVVEMKTFRDQFLAAEGQ---GELASFWLRKS.RKPVLAVLL..IEKA..-ASRSNE.SPTVV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGLNLagGD....IGSSDLVT.....GSTPL...ISTDQSE..ERVQ....EDGK......................--Teeellqvhtsavttfveptlvsgk.........................sgskttadvevavepdriqwtvsgP--Rlsedegakglilnde.......................cgqhcrasegcghgkrS--Reh.....................................vnEVTS.RSL.........TKPKRPrtfscdeli...sdsmresrtLPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVITFDNA.HCRHVYINQI-i..
A4IE07_LEIIN/127-253                 .................s-IIDLKKEQPNTFFSNATRMIQSFCRTHAHCSWRKHDpSRPVVTSVLtfVDVN.kCHCHLNG.DNPENtheehidapipadie.emgtpsgswcqcmrrGVIAVNYELSTPSGSRCSEQNAMGK-LAS-------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------lgv
Q38A89_TRYB2/370-496                 .................r-TLDLKREGAKSFFTNITLEILQFRSTMADCSWRKKDpMRQVVTSLMtyVDHK.kCHCNVTC.GSRRHwsmhkpalssngngmsnatfpdhswctcprsTVMAVNYELSTPSGSRCSEQNALGK-LAS-------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------mg.
A0A024GRI2_9STRA/349-596             .................p-MVQLVVQEMCIFRDQFLQAQGK---GEVESFWLRKS.RKPVLAVLL..VEKH..---EQDG.SVRLL...............................VHRGMNCEVSMPTGSLCAERNAIGSALAQDPTLCRRSLKMIAVLGVNL.lES....KTSVITTTrtitdSCELN...-PPRTES.lS---....-DNVynni.............ithksQ-Neglklssiratcqmt..........................................lsrafecereaghalsPSRP......................................................KR--.........................................----.---.........-----Prtfsiddy....tigesqlskIGDR...NP.LAPCGACKEWLMKIAE.....ANPSFRVITFENA.DCHNVYISQIM...
A4IE07_LEIIN/250-318                 ...............slg-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................--V.........................................................................PTWG......................................................VREV.........................................FVHG.R--.........-AAKEP.....................----...NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TPRKIVFLTI-p..
Q4CXE8_TRYCC/369-492                 .................n-IVDLRKEPEGSFLSKLCPIIMSFRQKNAHVSWRKKDpNRPVVTSLItyIDPE.eCDCQVDC.SGRGRppalmkpngrere....ekhprstwctctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------mgl
B7GB54_PHATC/685-977                 .................p-YRHLVIDEMKAFQAEMIKTLQGQ--NDIHRFWLRKT.HKPVLAVLL..VEQE..-------.-GQPI...............................LYRGTNMEVSMPTGSLCAERNVIGTALAANPSLRRQDLKMIAVLAVPW.qEK....LTDMGSAGt..lrSSEEP...FPALASS.sASLTsimcTTTLe...................sgE-GrktsigseheewilssapaggedgstgattnktrlppakselgnsfdlvdsgvpssssgvastapdrqpnddiPSTP......................................................VRRI.........................................ALFS.RSG.........TVARKSqqav............vlvqsTRDL...NP.LPPCGACNEWLKKIAE.....CNPYFCVLTFTDA.ECHGVYCTPCQ...
Q4DNI7_TRYCC/489-561                 ..............smgl-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................---.........................................................................PTSA......................................................IREI.........................................FVHG.EML.........GSKKDP.....................----...NP.LFPCGVCENMLRKVTRdvhdaYGGDVVLYMFDSTvNPKKLVYLPIN...
G5AGH2_PHYSP/357-655                 .................a-MTQMIVREMRIFRDQFLAAEGD---GEVASFWLRKS.RKPVLAVLL..IEKP..-AAVVGD.RPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLSRRALKMIAVLGLNL.tA-....EGPSSNVTs...pTASET...RGSEREG.pATCT....KDTK......................GNGngkrdps..........................................................daeatfdkPTSTstepgpelvaqpqpltvrirpageqsspernslslaaasprarshvggagrgrgKRGP.........................................ETKN.ANL.........TSPRKPkrprtfsmddvavdemlrasgPPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m..
A0A0G4ECT7_VITBC/341-386             .................v-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........----DP.....................KDEL...NP.IAPCGVCDEWLKKLQE.....ESPTFSIVTFTTS.DCDEI------ler
A0A0W8CV57_PHYNI/361-629             ..................AITQMIVREMRKFRDQFLAAEGE---GEVAGFWLRKS.RKPVLAVLL..IEKP..-AAELGG.RPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGLNLtaGG....NISVTSPT.....ASEDT...ADDKKEP.sDGAT....FDKK......................TSTa......................................................................vePANSqvlpvrvrpaavqssrss..................aavnnlsvddagrgrgrgKRAL.........................................ETKN.ANL.........TSPRKPkrprtfsfdevaveemmrasaPPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m..
A0A0G4ECT7_VITBC/249-344             .........plkrivdea----------RRYVNEWKSL-----EGQMDSFWHRKS.SKIVLAVVM..VVDK..-------.NGQER...............................FYRGMNSEISLPSGSNCAERAAISACISNSLTVRRSDFRAIAVV----..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------dpk
A0A0G4IVG2_PLABS/332-537             .............lhlgl------VEKMKERRQAFVLALRND--HELRAFWLRKT.FKPVLSVLL..VMKP..-------.GGVPQ...............................YFSGMNMEVSMPTGSLCAERNAIGNALAQDPTLHREHFKAMAVLSVSM..GS....ADPSNGDSt...sTHHWH...TDVASPPnsPTLA....ADAW......................DDR.........................................................................-RFN......................................................IRPT.........................................RSQT.MRH.........--ATTQsv................spyLRAL...NP.INPCGACKEWLKKIAL.....VNPDFVVLTFPSM.ICDSVFVRPV-l..
Q4DNI7_TRYCC/369-492                 .................n-IVDLRKEPEGSFLSKLCPIIMSFRQKNAHVSWRKKDpNRPVVTSLItyIDPE.eCDCQVDC.SGRGRppalikpngrere....ekhprstwcnctrsFVLAVNYELSTPSGSRCSEQNALGK-LAS-------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------mgl
A0A1V9Z9N5_9STRA/301-522             .................p-LVERLVAEMKAFRDCFVQG---QHLGEVGSFWLRKS.RKPVLAILL..IQKR..---LPTG.ELTTV...............................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLHRNALKMIGVLSV--..NL....APPMSAPQ.....IPALP...RAESLP-..TPLTp..tVHAAp...................teASS.........................................................................PKAKkpk................................................rprT--Fscdgt..............................tpavasALAS.VAM.........PKK--Ei..................ppPEDR...NP.LGPCGACNEWLLKIAE.....ANPSFKIITFGSM.ECESIYVHQ--ll.
A0A0G4EQ48_VITBC/40-132              plkrlvdearryvnewks------------------------LESQMDSFWHRKS.SKIVLAVVM..VVEK..-------.-GRLR...............................FYRGMNSEISLPSGSNCAERSAISTCISNMLTVRRSDFRAIAVV----..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........------.....................----...--.----------------.....-------------.-----------d..
A0A1X0NLM5_9TRYP/499-570             ...............mgl-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................---.........................................................................PTNA......................................................VREV.........................................FVHG.ENK.........GIQKDP.....................----...NP.LFPCGVCENMLRKVTRdvheaHGGNVMLYMFDSTeDPKRLVSLP--ln.
Q38A89_TRYB2/493-566                 ..............asmg-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................--L.........................................................................PTCA......................................................VREV.........................................FVHG.EHQ.........GSKKDP.....................----...NP.LFPCGVCENMLRKVAHdvleiHGGDVMLYMYDSThNPKRLVYLPI-t..
W4FZ70_9STRA/317-544                 .................p-LVARAVDEIKAFRDQFVQGEHL---GEVGQFWLRKS.RKPVLAVLL..VEKR..---TSSG.DVQVV...............................VHRGMNCEVSMPTGSLCAERNAIGSALANDPTLLRQSLKMIAVLSVSLhpLKlappPPPSLSST.....SLLLP...APPALIL..AHATt.ttVTTAvea...............spktGRK.........................................................................PKRP......................................................-RTIscdas..............................vpsiqaALDA.VDA.........SAAT--.....................EKDL...NP.LAPCGACNEWLLKIAE.....ANPSFKIVTFDSI.DCDSVYIHQ--ll.
H3GUA2_PHYRM/361-650                 .................a-LTQMIVREMRMFRDQFLAAEGE---GEVASFWLRKS.RKPVLAVLL..IEKP..-AAVAGE.RPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGLNL..SG....SGSNVISP.....TPSET...RGSEREG..G-AV....GDDG......................NKKpseaqaa...........................................................agptfdqP--Tststagptapalpvrirpacvqsspe..ppdankpaerqgsvggvgrgrgrgrgKRAL.........................................ENKN.ANL.........TSPRKPkrprtfsfdevaveemmrasaPPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m..
A0A0G4EQ48_VITBC/131-176             .................v-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................---.........................................................................----......................................................----.........................................----.---.........----DP.....................KDEL...NP.VFPCGVCDEWLKKLQE.....ESPMFSIVTFTTS.ECDAI------ler
Q4Q0G6_LEIMA/534-603                 ..............aslg-------------------------------------.---------..----..-------.-----...............................------------------------------------------------..--....--------.....-----...-------..----....----......................--V.........................................................................PTWG......................................................VREV.........................................FVHG.M--.........-AATEP.....................----...NP.LFPCGVCENMLRRVTKdvlahYGGDVTLYMFDAT.TPRKIVFLPI-p..
W2PRR7_PHYPN/372-640                 .................a-MTQMIVREMRKFRDQFLAAEGE---GEVAGFWLRKS.RKPVLAVLL..IEKP..-AAELGG.RPTIV...............................VQRGMNCEVSMPTGSLCAERNAIGSALASDPTLTRRALKMIAVLGLNLtaGG....NISVTSPT.....ASEDT...ADDKKEP.sDSAT....FDKK......................TSTavepans..........................................................qvlpvrvrPTAVqssrssaavnnl..............................svddagrgrgrgKRAL.........................................ETKN.ANL.........TSPRKPkrprtfsfdevaveemmrasaPPDR...NP.LAPCGACKEWLVKIAE.....ANPSFRVVTFENS.RCRNVYINQL-m..
#=GC seq_cons                        .................s.hhthhhpp.ptFhsphhth.t....schtsFWhRKo.pKPVLulLl..lpc........st.psp.h...............................h.pGhNhElShPoGShCuERNAIGssLAss.slhRpshhhluVl........................................................................................................................................................s............................................................h..........................................hts................pcs.......................th...NP.LhPCGsCpEWLhKlsE.....hsPsFpllhFpss.pCcplhh....h..
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