GenomeNet

Database: Pfam
Entry: Ly49
LinkDB: Ly49
Original site: Ly49 
#=GF ID   Ly49
#=GF AC   PF08391.12
#=GF DE   Ly49-like protein, N-terminal region
#=GF AU   Fenech M;0000-0001-7933-4617
#=GF SE   Pfam-B_1187 (release 18.0)
#=GF GA   31.50 31.50;
#=GF TC   31.50 31.50;
#=GF NC   31.40 31.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0056
#=GF RN   [1]
#=GF RM   15607796
#=GF RT   Mouse Ly49 NK receptors: balancing activation and inhibition. 
#=GF RA   Ortaldo JR, Young HA; 
#=GF RL   Mol Immunol 2005;42:445-450.
#=GF RN   [2]
#=GF RM   10925254
#=GF RT   Ly-49P activates NK-mediated lysis by recognizing H-2Dd. 
#=GF RA   Silver ET, Gong DE, Chang CS, Amrani A, Santamaria P, Kane KP; 
#=GF RL   J Immunol 2000;165:1771-1781.
#=GF DR   INTERPRO; IPR013600;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The sequences making up this family are annotated as, or are
#=GF CC   similar to, Ly49 receptors (e.g. Swiss:P20937). These are type
#=GF CC   II transmembrane receptors expressed by mouse natural killer
#=GF CC   (NK) cells. They are classified as being activating (e.g.Ly49D
#=GF CC   and H) or inhibitory (e.g. Ly49A and G), depending on their
#=GF CC   effect on NK cell function [1]. They are members of the C-type
#=GF CC   lectin receptor superfamily [2], and in fact in many family
#=GF CC   members this region is found immediately N-terminal to a lectin
#=GF CC   C-type domain (Pfam:PF00059).
#=GF SQ   267
#=GS A0A3Q7VAR0_URSAR/41-157   AC A0A3Q7VAR0.1
#=GS G3I5X3_CRIGR/28-123       AC G3I5X3.1
#=GS A0A3Q0H749_ALLSI/20-73    AC A0A3Q0H749.1
#=GS M0R7G8_RAT/40-158         AC M0R7G8.1
#=GS KLRA5_MOUSE/40-157        AC Q60652.1
#=GS F6VXA1_HORSE/41-167       AC F6VXA1.2
#=GS L8HPP1_9CETA/41-166       AC L8HPP1.1
#=GS Q5MPP6_RAT/40-158         AC Q5MPP6.1
#=GS A0A0G2K6C6_RAT/40-158     AC A0A0G2K6C6.1
#=GS A0A3Q7W7Q7_URSAR/36-157   AC A0A3Q7W7Q7.1
#=GS A0A286Y472_CAVPO/37-162   AC A0A286Y472.1
#=GS A0A2Y9NE98_DELLE/32-157   AC A0A2Y9NE98.1
#=GS Q5MPW6_RAT/37-156         AC Q5MPW6.1
#=GS A0A2U3WTI6_ODORO/36-157   AC A0A2U3WTI6.1
#=GS A0A2K5XX51_MANLE/41-166   AC A0A2K5XX51.1
#=GS A0A1S2Z9C6_ERIEU/41-163   AC A0A1S2Z9C6.1
#=GS A0A2I3GWX2_NOMLE/36-141   AC A0A2I3GWX2.1
#=GS A0A2K6KSR9_RHIBE/41-166   AC A0A2K6KSR9.1
#=GS A0A384CMM0_URSMA/36-157   AC A0A384CMM0.1
#=GS A0A452FPT3_CAPHI/41-165   AC A0A452FPT3.1
#=GS A0A340Y8B0_LIPVE/32-157   AC A0A340Y8B0.1
#=GS A0A2R8ZRK6_PANPA/32-158   AC A0A2R8ZRK6.1
#=GS F1MY78_BOVIN/36-157       AC F1MY78.1
#=GS A0A286XSC8_CAVPO/11-130   AC A0A286XSC8.1
#=GS A0A452RNS9_URSAM/36-136   AC A0A452RNS9.1
#=GS M0R6A0_RAT/40-159         AC M0R6A0.1
#=GS G1SYL0_RABIT/41-167       AC G1SYL0.3
#=GS A0A452RNS7_URSAM/27-61    AC A0A452RNS7.1
#=GS A0A0G2K3K6_RAT/37-155     AC A0A0G2K3K6.1
#=GS A0A3Q2ICZ7_HORSE/41-166   AC A0A3Q2ICZ7.2
#=GS A0A5F9DGE7_RABIT/32-158   AC A0A5F9DGE7.1
#=GS A0A2R9AB46_PANPA/36-157   AC A0A2R9AB46.1
#=GS A0A3Q2LTQ5_HORSE/183-308  AC A0A3Q2LTQ5.2
#=GS A0A2R8ZSS2_PANPA/32-158   AC A0A2R8ZSS2.1
#=GS A0A2K6L5E5_RHIBE/32-158   AC A0A2K6L5E5.1
#=GS A0A2K6RVT3_RHIRO/10-135   AC A0A2K6RVT3.1
#=GS G1SGB2_RABIT/41-167       AC G1SGB2.2
#=GS M3WD61_FELCA/36-157       AC M3WD61.1
#=GS A0A2I3RTS7_PANTR/36-135   AC A0A2I3RTS7.1
#=GS A0A1U7TTE3_CARSF/41-166   AC A0A1U7TTE3.1
#=GS E9PU26_RAT/40-158         AC E9PU26.1
#=GS F6TVW9_HORSE/41-167       AC F6TVW9.2
#=GS A0A2K6SH66_SAIBB/36-157   AC A0A2K6SH66.1
#=GS A0A5F5PLI5_HORSE/129-254  AC A0A5F5PLI5.1
#=GS A0A5F9DLC3_RABIT/41-167   AC A0A5F9DLC3.1
#=GS Q9D3R1_MOUSE/40-159       AC Q9D3R1.1
#=GS A0A2K6FG86_PROCO/31-158   AC A0A2K6FG86.1
#=GS A0A1U8BUK0_MESAU/39-158   AC A0A1U8BUK0.1
#=GS A0A2K6FG83_PROCO/31-158   AC A0A2K6FG83.1
#=GS A0A2U3ZRI6_ODORO/41-157   AC A0A2U3ZRI6.1
#=GS H2NGJ1_PONAB/41-166       AC H2NGJ1.2
#=GS A0A5F5Y2I0_FELCA/25-90    AC A0A5F5Y2I0.1
#=GS A0A5F5PUQ5_HORSE/183-308  AC A0A5F5PUQ5.1
#=GS A0A384B9E7_BALAS/35-156   AC A0A384B9E7.1
#=GS A0A673T6K6_SURSU/36-157   AC A0A673T6K6.1
#=GS A0A673U2A2_SURSU/74-187   AC A0A673U2A2.1
#=GS M0RAM6_RAT/37-105         AC M0RAM6.1
#=GS A0A0G2K1B9_RAT/40-158     AC A0A0G2K1B9.1
#=GS D3ZG59_RAT/40-159         AC D3ZG59.2
#=GS A0A0G2JZN5_RAT/37-155     AC A0A0G2JZN5.1
#=GS G1TCF2_RABIT/36-162       AC G1TCF2.1
#=GS A0A3P4M6N7_GULGU/36-157   AC A0A3P4M6N7.1
#=GS F7IR53_CALJA/36-157       AC F7IR53.3
#=GS Q5M837_RAT/37-138         AC Q5M837.1
#=GS A0A1U7QW19_MESAU/41-159   AC A0A1U7QW19.1
#=GS H2Q5F3_PANTR/32-158       AC H2Q5F3.1
#=GS A0A452QL65_URSAM/27-152   AC A0A452QL65.1
#=GS A0A2R9CCG5_PANPA/41-165   AC A0A2R9CCG5.1
#=GS A0A096NW98_PAPAN/41-166   AC A0A096NW98.1
#=GS G1LZR7_AILME/38-160       AC G1LZR7.1
#=GS A0A2Y9E3K2_TRIMA/37-157   AC A0A2Y9E3K2.1
#=GS A0A0G2JYA0_RAT/4-123      AC A0A0G2JYA0.1
#=GS G3R0F9_GORGO/36-157       AC G3R0F9.1
#=GS H0VLX5_CAVPO/41-159       AC H0VLX5.2
#=GS F6XRH5_ORNAN/49-156       AC F6XRH5.2
#=GS A0A3Q0DJB0_CARSF/35-151   AC A0A3Q0DJB0.1
#=GS G1PIT6_MYOLU/33-154       AC G1PIT6.1
#=GS A0A5J5MZY7_MUNRE/36-157   AC A0A5J5MZY7.1
#=GS A0A5F5PF74_HORSE/129-254  AC A0A5F5PF74.1
#=GS Q8SPQ6_BOVIN/41-166       AC Q8SPQ6.1
#=GS A0A452QL66_URSAM/38-157   AC A0A452QL66.1
#=GS A0A2I3RD65_PANTR/32-158   AC A0A2I3RD65.1
#=GS A0A671F856_RHIFE/32-158   AC A0A671F856.1
#=GS L8YBJ6_TUPCH/30-116       AC L8YBJ6.1
#=GS A0A671F4P2_RHIFE/32-148   AC A0A671F4P2.1
#=GS A0A0D9R8W3_CHLSB/43-168   AC A0A0D9R8W3.1
#=GS A0A2I3HNK5_NOMLE/41-171   AC A0A2I3HNK5.1
#=GS A0A0G2K5S8_RAT/1-68       AC A0A0G2K5S8.1
#=GS A0A0G2K4W0_RAT/40-158     AC A0A0G2K4W0.1
#=GS I2CVJ0_MACMU/36-157       AC I2CVJ0.1
#=GS A0A6G1AYH0_CROCR/41-154   AC A0A6G1AYH0.1
#=GS A0A2K6ACJ2_MANLE/36-157   AC A0A2K6ACJ2.1
#=GS G1TRV0_RABIT/45-171       AC G1TRV0.2
#=GS A0A3Q2I9T9_HORSE/41-166   AC A0A3Q2I9T9.1
#=GS A0A1A6H558_NEOLE/88-201   AC A0A1A6H558.1
#=GS A0A4W2CA15_BOBOX/76-197   AC A0A4W2CA15.1
#=GS A0A671F4H9_RHIFE/32-153   AC A0A671F4H9.1
#=GS Q75XR1_HORSE/41-167       AC Q75XR1.1
#=GS A0A2K5TTK1_MACFA/36-157   AC A0A2K5TTK1.1
#=GS A0A2U3XL42_LEPWE/36-162   AC A0A2U3XL42.1
#=GS A0A2Y9NUT7_DELLE/32-157   AC A0A2Y9NUT7.1
#=GS A0A5F9D5T1_RABIT/45-171   AC A0A5F9D5T1.1
#=GS A0A5F9CF01_RABIT/125-251  AC A0A5F9CF01.1
#=GS A0A3Q0CEN5_MESAU/41-159   AC A0A3Q0CEN5.1
#=GS G1Q5R9_MYOLU/41-161       AC G1Q5R9.1
#=GS OLR1_HUMAN/32-158         AC P78380.1
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL9 G; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL7 A; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPU A; 140-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPQ B; 136-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPO B; 142-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPO F; 142-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL9 F; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YXK B; 136-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL9 C; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPO E; 142-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL9 D; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL7 B; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPO D; 142-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TLA B; 137-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YXK A; 141-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL9 E; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPU B; 136-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPQ A; 140-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPO C; 142-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPO A; 142-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TLA C; 142-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL9 A; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YXJ B; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL9 B; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TLA A; 139-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 3VLG A; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YXJ A; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPO G; 142-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 6TL9 H; 143-158;
#=GS OLR1_HUMAN/32-158         DR PDB; 1YPO H; 142-158;
#=GS A0A5F5PTX7_HORSE/41-166   AC A0A5F5PTX7.1
#=GS F6XT03_CANLF/37-158       AC F6XT03.1
#=GS A0A2K5L370_CERAT/41-166   AC A0A2K5L370.1
#=GS A0A452QEN0_URSAM/1-94     AC A0A452QEN0.1
#=GS Q9JMA4_MOUSE/40-158       AC Q9JMA4.1
#=GS F1SQ43_PIG/41-153         AC F1SQ43.2
#=GS A0A0G2K3B3_RAT/50-168     AC A0A0G2K3B3.1
#=GS A0A3Q0HA07_ALLSI/36-126   AC A0A3Q0HA07.1
#=GS A0A2Y9H8K0_NEOSC/36-157   AC A0A2Y9H8K0.1
#=GS A0A452REE0_URSAM/36-139   AC A0A452REE0.1
#=GS A0A0G2KA96_RAT/3-122      AC A0A0G2KA96.1
#=GS A0A5F4C5H3_CANLF/32-158   AC A0A5F4C5H3.1
#=GS A0A3Q0CEP0_MESAU/40-153   AC A0A3Q0CEP0.1
#=GS G1P8R8_MYOLU/32-158       AC G1P8R8.1
#=GS A0A2I2U6I4_FELCA/41-155   AC A0A2I2U6I4.1
#=GS A0A485NJI8_LYNPA/41-155   AC A0A485NJI8.1
#=GS G3I5X3_CRIGR/152-242      AC G3I5X3.1
#=GS A0A3Q0H8J8_ALLSI/75-126   AC A0A3Q0H8J8.1
#=GS A0A3Q7S626_VULVU/1-76     AC A0A3Q7S626.1
#=GS A0A2I3TPD9_PANTR/41-165   AC A0A2I3TPD9.1
#=GS A0A455BDJ2_PHYMC/41-167   AC A0A455BDJ2.1
#=GS A0A0G2KAD3_RAT/40-156     AC A0A0G2KAD3.1
#=GS G1TRD4_RABIT/45-171       AC G1TRD4.2
#=GS A0A3P4LVF1_GULGU/41-157   AC A0A3P4LVF1.1
#=GS KLRA3_MOUSE/40-157        AC Q64329.2
#=GS KLRA3_MOUSE/40-157        DR PDB; 3C8J A; 136-153;
#=GS KLRA3_MOUSE/40-157        DR PDB; 3C8J C; 137-153;
#=GS KLRA3_MOUSE/40-157        DR PDB; 5J6G H; 145-157;
#=GS KLRA3_MOUSE/40-157        DR PDB; 3C8K D; 138-153;
#=GS KLRA3_MOUSE/40-157        DR PDB; 1P1Z D; 144-156;
#=GS KLRA3_MOUSE/40-157        DR PDB; 3C8J D; 133-153;
#=GS KLRA3_MOUSE/40-157        DR PDB; 5J6G G; 144-157;
#=GS KLRA3_MOUSE/40-157        DR PDB; 3C8J B; 137-153;
#=GS KLRA3_MOUSE/40-157        DR PDB; 1P4L D; 138-153;
#=GS A0A287AUR9_PIG/31-88      AC A0A287AUR9.1
#=GS A0A3Q0H6I6_ALLSI/69-202   AC A0A3Q0H6I6.1
#=GS A0A287BSB2_PIG/35-155     AC A0A287BSB2.1
#=GS H0X8N3_OTOGA/42-169       AC H0X8N3.1
#=GS A0A3Q2H429_HORSE/41-167   AC A0A3Q2H429.1
#=GS KLRA1_MOUSE/40-153        AC P20937.1
#=GS KLRA1_MOUSE/40-153        DR PDB; 1QO3 C; 126-153;
#=GS KLRA1_MOUSE/40-153        DR PDB; 1QO3 D; 139-153;
#=GS A0A5J5N0D7_MUNRE/41-165   AC A0A5J5N0D7.1
#=GS F6W8N3_HORSE/41-161       AC F6W8N3.2
#=GS A0A452QEY6_URSAM/41-169   AC A0A452QEY6.1
#=GS Q9R1G6_MOUSE/40-157       AC Q9R1G6.1
#=GS OLR1_RABIT/32-158         AC Q9XTA8.2
#=GS A0A2K6CHB7_MACNE/36-157   AC A0A2K6CHB7.1
#=GS A0A5F9CDQ9_RABIT/36-137   AC A0A5F9CDQ9.1
#=GS E9PTN0_RAT/40-158         AC E9PTN0.3
#=GS A0A3Q7T8T0_VULVU/36-157   AC A0A3Q7T8T0.1
#=GS A0A4D9DMR2_9SAUR/46-153   AC A0A4D9DMR2.1
#=GS A0A2U3XL37_LEPWE/36-157   AC A0A2U3XL37.1
#=GS W5QIP2_SHEEP/37-155       AC W5QIP2.1
#=GS G3RBI0_GORGO/41-166       AC G3RBI0.1
#=GS Q5MPP5_RAT/40-157         AC Q5MPP5.1
#=GS A0A6G1ABE6_CROCR/36-157   AC A0A6G1ABE6.1
#=GS A0A0G2K7E2_RAT/40-159     AC A0A0G2K7E2.1
#=GS A0A3Q0H764_ALLSI/87-138   AC A0A3Q0H764.1
#=GS A0A151NDR4_ALLMI/82-133   AC A0A151NDR4.1
#=GS A0A5E4D547_MARMO/41-161   AC A0A5E4D547.1
#=GS A0A0G2K381_RAT/86-205     AC A0A0G2K381.1
#=GS A0A4W2DAZ6_BOBOX/31-87    AC A0A4W2DAZ6.1
#=GS W5QII8_SHEEP/38-159       AC W5QII8.1
#=GS A0A1A6FT98_NEOLE/1-84     AC A0A1A6FT98.1
#=GS A0A2Y9F4P7_PHYMC/32-158   AC A0A2Y9F4P7.1
#=GS A0A2K6LTK5_RHIBE/36-157   AC A0A2K6LTK5.1
#=GS A0A286XDG1_CAVPO/11-130   AC A0A286XDG1.1
#=GS A0A2K5HMF3_COLAP/36-157   AC A0A2K5HMF3.1
#=GS A0A151MWC9_ALLMI/28-149   AC A0A151MWC9.1
#=GS A0A0G2K4E0_RAT/40-158     AC A0A0G2K4E0.1
#=GS E2RFX2_CANLF/36-162       AC E2RFX2.2
#=GS A0A2Y9IUL5_ENHLU/56-166   AC A0A2Y9IUL5.1
#=GS Q5MPW9_RAT/40-158         AC Q5MPW9.1
#=GS Q2TJJ8_MOUSE/40-157       AC Q2TJJ8.1
#=GS A0A0G2KAZ0_RAT/40-159     AC A0A0G2KAZ0.1
#=GS M0R9S7_RAT/40-155         AC M0R9S7.1
#=GS G5BE02_HETGA/41-157       AC G5BE02.1
#=GS A0A452RNR9_URSAM/41-166   AC A0A452RNR9.1
#=GS KLRA8_MOUSE/40-157        AC Q60682.1
#=GS KLRA8_MOUSE/40-157        DR PDB; 4JO8 B; 109-130;
#=GS A0A2K6PM24_RHIRO/41-166   AC A0A2K6PM24.1
#=GS A0A3Q0CAM7_MESAU/36-150   AC A0A3Q0CAM7.1
#=GS A0A2Y9IRY2_ENHLU/15-131   AC A0A2Y9IRY2.1
#=GS F6TWU8_HORSE/41-167       AC F6TWU8.3
#=GS A0A673TQQ2_SURSU/41-154   AC A0A673TQQ2.1
#=GS A0A485NWV2_LYNPA/36-157   AC A0A485NWV2.1
#=GS KLRA6_MOUSE/40-157        AC Q60653.1
#=GS CL12B_BOVIN/36-157        AC Q2NL33.1
#=GS F7C481_MACMU/41-166       AC F7C481.2
#=GS A0A151MW76_ALLMI/61-182   AC A0A151MW76.1
#=GS A0A2K5LCK5_CERAT/36-157   AC A0A2K5LCK5.1
#=GS A0A5E4D6K5_MARMO/1-98     AC A0A5E4D6K5.1
#=GS F6PJX7_CANLF/40-156       AC F6PJX7.2
#=GS A0A2Y9IQM8_ENHLU/36-157   AC A0A2Y9IQM8.1
#=GS A0A2Y9H3Y5_NEOSC/36-162   AC A0A2Y9H3Y5.1
#=GS F7EVP3_RAT/40-159         AC F7EVP3.1
#=GS A0A3Q0H769_ALLSI/43-94    AC A0A3Q0H769.1
#=GS A0A1A6HCC5_NEOLE/35-130   AC A0A1A6HCC5.1
#=GS CL12B_HUMAN/36-157        AC Q2HXU8.1
#=GS A0A3Q0CFM7_MESAU/41-159   AC A0A3Q0CFM7.1
#=GS A0A2K5K850_COLAP/41-166   AC A0A2K5K850.1
#=GS F7CLL3_MOUSE/1-67         AC F7CLL3.1
#=GS A0A1A6HPL8_NEOLE/41-160   AC A0A1A6HPL8.1
#=GS A0A1A6GIS1_NEOLE/35-129   AC A0A1A6GIS1.1
#=GS A0A0G2JVR1_RAT/37-155     AC A0A0G2JVR1.1
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A0A3Q7VAR0_URSAR/41-157              ............SVPWHLISVTLGILCLLLLVT.VALLGT..K..ISQYIQENHQQ.REEIgNLT..R.....E........H.....HIL.....Q....ND.S...Y.LK....E...R...L....LIN.KT.LE.Y.N.ILKN.......ESLQQKK..E.....QD.....L.L.....FS..G..R...-T.....--YQRENE.............GKL...C...E.NRLSYR.GIKYYYF............................................
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M0R7G8_RAT/40-158                    ............SVPWQLIVVALVILCSLRLVA.VVMFVT..N..IFQYTHEKHEL.HETL.SHK..Y.....N........C.....TSM.....P....ND.I...D.LK....E...E...M....LRN.MF.IN.C.S.RGND.......LLLSLKR..E.....QT.....R.W.....YR..E..T...KT.....VIPSFQHT.............GKN...V...E.IYWFCY.GIKCYYF............................................
KLRA5_MOUSE/40-157                   ............SVPWQLTVRSLGIFCFLLLVT.VAVLAV..K..IFQYSQHKQEI.HETL.NHN..H.....N........C.....SNM.....Q....SD.I...K.LK....E...E...M....LRN.KS.ID.C.S.PGEE.......LLESLNR..E.....QN.....R.W.....YS..E..T...KT.....DLDSSQDT.............GTG...V...K.-HWFCY.GTKCFYF............................................
F6VXA1_HORSE/41-167                  ............SVPWHPFVVTLGILCLLLLVT.VTVLGT..M..IFQCFKEKHQQ.EEILrKLI..P.....Q........Y.....DSI.....R....NN.N...Y.SK....E...Q...L....LIN.KT.LE.C.D.ILKNqtlhqkkELDSLFM..E.....KM.....R.C.....HI..K..Q...EI.....FSKSLQST.............GKF...N...E.DHWSCC.GVNCYYF............................................
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Q5MPW6_RAT/37-156                    ...........r-VCWQITVTALGILCFFRLVS.VAVMVI..N..IFQYSQEKHEL.QETLsNLH..H.....N........Y.....STM.....Q....ND.I...N.LK....E...E...M....LRD.MS.TE.Y.S.AVNH.......FLDFLNR..E.....KN.....R.C.....YN..K..T...KT.....VLDSSQHS.............GRG...V...E.MHWFCY.GIKCYYF............................................
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A0A340Y8B0_LIPVE/32-157              ..........sr--RWYLAAMALGILCLGLLVT.VILLII..Q..LSQVSDLKQQQ.A---.NLT..H.....Q........E.....DIL.....E....GQ.I...S.AQ....H...Q...T....EKS.SQ.ES.Q.R.ELKEmietlahKLDEKSK..K.....LM.....E.L.....HH..Q..N...LN.....LQEA----.............---...-...-.------.-------lkkaanypgpcpqdwlwheencyqf...................
A0A2R8ZRK6_PANPA/32-158              .........spw---WCLAAATLGVLCLGLVVT.IMVLGM..Q..LSQVSDLLTQE.QANL.--T..H.....Q........K.....KKL.....E....GQ.I...S.AR....Q...Q...A....EEA.SQ.ES.Q.N.ELKEmietlarKLNEKSK..E.....QM.....E.L.....HH..Q..N...LN.....LQETLKRVa..........ncSAP...C...P.QDWIWH.GENCYLF............................................
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M0R6A0_RAT/40-159                    ............SVPWQLIVIALGILCSLLLVT.VAVLLT..K..IFQYNHEKHALpEETL.SPI..N.....N........C.....STM.....Q....SN.I...D.LK....E...E...M....LRN.MS.IN.C.S.QGND.......LLQSLNR..E.....QT.....K.W.....YS..E..T...KT.....VLPSSQHT.............GKN...V...E.IYWFCY.GIKCYYF............................................
G1SYL0_RABIT/41-167                  ............SVPRHLLAVTLGILCLLLSVA.VAVLVT..K..ILQLIQEKHQQ.QEILgNLT..Q.....M........Y.....HVV.....Q....ND.D...Y.LN....K...Q...L....LAN.KS.LE.Y.D.TLKNktllmenALKSLFL..K.....WN.....G.C.....NA..K..K...DT.....FPKSVHNP.............GKV...H...E.DYWSCY.GVNCYYF............................................
A0A452RNS7_URSAM/27-61               ............SVPWHLISVTLGILCLLLLVT.VALLGT..K..-----------.----.---..-.....-........-.....---.....-....--.-...-.--....-...-...-....---.--.--.-.-.----.......-------..-.....--.....-.-.....--..-..-...--.....--------.............---...-...-.------.-------sdhlsyr.....................................
A0A0G2K3K6_RAT/37-155                ...........r-VPWQLTVIAIGIILSLRLVA.VAILVT..N..IFQYSNEKHEL.QKTQ.NRQ..H.....N........C.....STM.....E....KD.I...N.LK....E...E...T....LRN.MS.VE.S.V.HYNA.......LLDLINR..E.....QN.....R.W.....YK..K..T...KT.....VLASPQHT.............GGC...D...E.MHWFCY.GIKCYYF............................................
A0A3Q2ICZ7_HORSE/41-166              ............SVPWHLFVVTVGILCLLLLVT.VRVSGT..M..IFQCIQEKQQE.ESRQ.NFS..Q.....K........Y.....NIM.....Q....KE.N...Y.LK....E...Q...L....LTN.KT.LE.Y.G.ILKNqtlqqkkEIASLFK..E.....KM.....R.C.....HR..K..Q...GI.....LSKSLQNT.............GKL...Y...D.NRWSCC.GVNCYYF............................................
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G1SGB2_RABIT/41-167                  ............SVPRHLLAVTLGILCLLLSVA.VAVLVT..K..ILQLIQEKHQQ.QEILgNLT..Q.....M........Y.....HVV.....Q....ND.D...Y.LK....K...Q...L....LAN.KS.LE.Y.D.TLKNktllmenALKSPFL..K.....QN.....G.R.....CA..K..K...DT.....VPKSVHNP.............GKV...H...E.DYWSCY.GVNCYYF............................................
M3WD61_FELCA/36-157                  ..........sp--IWRQAALSLLTLCLMLLIG.LVTLGI..M..LLQTSHEINSD.SERLsQLQ..K.....T........I.....HQQ.....Q....DN.F...S.QQ....L...S...D....YRN.FP.TG.E.E.HLKS.......QISSLLK..R.....QE.....Q.M.....AI..KlcQ...EL.....IIRTSDHK.............CNP...C...P.KMWQWY.QNSCYYF............................................
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E9PU26_RAT/40-158                    ............SVLWQHIKIALGILCSHLLVT.LAVLAM..S..IIQYSQENHDL.QKTL.KHH..H.....N........C.....STM.....Q....SI.I...D.LK....G...E...M....MRN.KS.IE.C.R.SGSE.......YLDSLKR..E.....QE.....R.W.....NR..K..T...KT.....ILNSTEHI.............GKG...V...K.IHWFCY.GIKCYYF............................................
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M0RAM6_RAT/37-105                    ...........r-VPWQLTVIATGILLSLRLFA.VAMLVT..N..IFQYSHEKYDL.QKTQ.NYH..Q.....N........C.....STM.....E....ND.I...N.LK....E...E...M....ERN.MH.IE.-.-.----.......-------..-.....--.....-.-.....--..-..-...--.....--------.............---...-...-.------.-------............................................
A0A0G2K1B9_RAT/40-158                ...........y-VPWHLIVIALGILCTLLLLT.VAVLVT..I..IFQYSQEKHEL.QETL.NHH..H.....N........C.....SAM.....Q....RD.I...D.LK....E...E...M....LRK.IS.ID.C.S.PGND.......LLESFNR..S.....KN.....R.W.....YS..K..T...KA.....VVNSSQHK.............GSE...I...E.TYWFCY.GIKCYY-v...........................................
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A0A0G2JZN5_RAT/37-155                ...........r-VPWQLTVIAIGILLSLRLVA.VAMLVT..N..IFQYSHEKHEL.QKTR.NCH..H.....N........C.....STM.....E....ND.I...K.LK....E...E...T....LRN.MS.VE.C.T.PSNT.......LLNLFNR..E.....QN.....R.W.....YK..K..T...KT.....VLASPQHT.............ARC...V...E.MHWFCH.GIKCYF-i...........................................
G1TCF2_RABIT/36-162                  .........spw---WCPAAVALGVLCLGSLVT.IIMLGM..Q..LLQVSDLLKQQ.QANL.TLQ..E.....N........I.....LEG.....QvlaqQQaE...A.AS....Q...E...S....QRE.LK.EM.I.E.TLAK.......RLDEKSK..K.....QM.....E.L.....NH..Q..YlnlQE.....ALKRMDNF.............SGP...C...P.EDWLWH.GKNCYLF............................................
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Q5M837_RAT/37-138                    ...........r-VPWQLTVIAIGILLSLRLVA.VAMLVT..N..IFQYNHETHEL.QKTR.NCH..H.....N........C.....STM.....E....KD.I...N.LK....E...E...M....LRN.MS.VE.S.V.HYNA.......LLDLISR..E.....EN.....R.W.....YN..K..T...KT.....VLASPQH-.............---...-...-.------.-------ir..........................................
A0A1U7QW19_MESAU/41-159              ............SVPCNFITKFLGILSCILLVA.VAVLVI..Y..IFQYDQENHEL.KKTLnNHH..Q....kE........F.....NIK.....Q....ND.S...Y.LK....D...E...M....LRN.KS.TE.L.E.ALKK.......YLDSLNR..K.....QN.....R.C.....HG..E..T...KV.....VLDCKQPS.............GKH...V...E.AQWFCC.GIKCY--............................................
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A0A0G2K5S8_RAT/1-68                  ............---------------------.------..-..-----------.----.---..-.....-........-.....--M.....Q....SD.I...D.LN....E...E...M....LRN.KS.ID.C.S.TGND.......LLESLNR..E.....QN.....R.W.....YS..K..T...KA.....VVKSSQHT.............GSE...I...E.TYCFCY.GIKCYY-v...........................................
A0A0G2K4W0_RAT/40-158                ............SVPWKLIVIALAILCSVLMVT.VAALVT..N..IFQYSNEKHEL.QKTQ.NCH..H.....N........C.....STI.....E....ND.I...K.LK....E...E...M....LRN.IS.VE.S.V.HYNA.......FLDLINR..E.....QK.....R.W.....YK..K..T...KT.....VLASPQHT.............GRC...D...E.MHWFCY.GIKCYYF............................................
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G1TRV0_RABIT/45-171                  ............SVPWHLIAVILGTLCLLLSVM.VRVLEA..N..ILQLIQEKHQQ.QEILgNLT..Q.....M........Y.....HVV.....Q....ND.D...Y.LK....K...Q...L....LAN.QS.LE.Y.D.TLKNktllmenALKSPFL..K.....QN.....G.R.....CA..K..K...DT.....FPKSVHNP.............GKV...H...E.VYWSCY.GVNCYYF............................................
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A0A2Y9H3W7_NEOSC/41-157              ............SVTWHLIAVILGILCLLLSVT.VALLGT..K..IFQYIQENHQL.GEMIgNLT..R.....E........H.....HIL.....Q....ND.S...Y.LK....E...R...L....LTN.MT.LG.Y.N.ILKN.......ESLQQKK..E.....QD.....L.L.....FA..D..R...RC.....---QKENE.............GKL...Y...E.NRWSCC.GIKCYYF............................................
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A0A3Q7VX40_URSAR/41-147              ............SVPWHLISVTLGILCLLLLVT.VALLGT..K..IFQYIQENHQQ.KEEIgNLT..R.....E........H.....HIL.....Q....NE.S...Y.LK....E...R...L....LTN.KT.LE.Y.N.ILKN.......ESLQQKK..E.....QD.....L.L.....FS..G..R...TY.....--------.............---...-...-.------.-------qrenegmtgilhe...............................
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G1SSY7_RABIT/37-157                  ..........pa---WRQAALGLFILCLMLLIG.LVTLGI..M..FLQMSNEMNSD.SEKR.NQL..Q.....K........I.....IH-.....Q....QQ.D...N.LS....Q...Q...Ld..nHRN.LP.AQ.E.E.SLKS.......QISDLLK..R.....QG.....Q.L.....AIrlC..E...EL.....IIHMSDHR.............CNP...C...P.ETWQWY.QNSCYYF............................................
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A0A3Q2H093_HORSE/183-308             ............SVPWHLLVVTLGILCLLLLVA.VTVLGT..M..IFRCIREKQQE.ESRQ.NLS..Q.....K........Y.....NIM.....Q....KE.N...Y.LK....E...Q...L....LTN.KT.LE.Y.G.ILKNqtlqqkkEIASLFK..E.....KM.....R.C.....HR..K..Q...GI.....LSRSLQNT.............GKL...Y...D.NRWSCC.GVNCYYF............................................
A0A5F5PW67_HORSE/41-167              ............SVPWHPFVVTLGILCLLLLVT.VTVLGT..M..IFQCFKEKHQQ.EEILrKLI..P.....Q........Y.....DSI.....R....NN.N...Y.SK....E...Q...L....LIN.KT.LE.C.D.ILKNqtlhqkkELDSLFM..E.....KM.....R.C.....HI..K..Q...EI.....FSKSLQST.............GKF...N...E.DHWSCC.GVNCYYF............................................
A0A4W2EX23_BOBOX/41-166              ............SVPWHGIAVTLGILCLLLLMT.ITVLGI..K..ISQYILEKHQQ.EEALrNLS..Q.....K........Y.....DVV.....Q....ND.N...Y.LN....K...Q...L....LTK.KT.SE.C.D.RLNEtlqqikgLSDLVFT..E.....KK.....G.C.....YH..K..K...KS.....-SESLPNT.............GEL...K...E.VSWWCW.GVNCYYF............................................
A0A5F9CSL8_RABIT/41-167              ............SVPWHLIAVILGTLCLLLSVM.VRVLEA..N..ILQLIQEKHQQ.QEILgNLT..Q.....M........Y.....HVV.....Q....ND.D...Y.LK....K...Q...L....LAN.QS.LE.Y.D.TLKNktllmenALKSPFL..K.....QN.....G.R.....CA..K..K...DT.....FPKSVHNP.............GKV...H...E.VYWSCY.GVNCYYF............................................
M3W9H7_FELCA/41-155                  ............SVPWHLIAVILGILCFLLLVT.VAVLGT..K..IFQYIQENHQQ.RENIrNLS..Q.....E........Y.....QIV.....Q....ND.S...Y.FK....E...Q...L....LTN.KI.LE.C.N.SREN.......ESLQQKM..K.....QD.....F.I.....ER..T..-...--.....--CQRKNI.............GKL...Y...E.SHWSCC.GIKCYYF............................................
A0A151NDH2_ALLMI/83-134              ............SLQWRLTAVIFGILCLILLVA.TGVLGI..I..VMELSQEKKDP.TQCL.K--..-.....-........-.....---.....-....--.-...-.--....-...-...-....---.--.--.-.-.----.......-------..-.....--.....-.-.....--..-..-...--.....--------.............---...-...-.------.-------scpdpnrs....................................
CL12B_MOUSE/36-156                   ..........ss--LWRGAALSLMTLCLVLVTG.LVTLAT..M..FLQVSNDINSD.SEKLsQLQ..K.....S........I.....HPQ.....-....QD.N...-.LS....E...S...L...nSSR.KS.LT.E.E.SLQS.......QISALLE..R.....QE.....Q.M.....AT..KlcK...EF.....LIHASDHK.............CNP...C...P.KTWQWY.GNSCYYF............................................
#=GC SS_cons                         ............XXXXXXXXXXXXXXXXXXXXX.XXXXXX..X..XXXXXXXXXXX.XXXX.XXX..X.....X........X.....XXX.....X....XX.X...X.XX....X...X...X....XXX.XX.XX.X.X.XXHH.......HHHHHHH..H.....HH.....H.H.....HH..H..H...HT.....TTSXSXSXXXXXXXXXXXXSSSXS...S...C.CEEEEE.TTEEEEE............................................
#=GC seq_cons                        ...............WphhulsLGILCLhLLls.lslLsh..p..lhQhspEp+pp.p-pL.shp..p.....p........h.....phh.....Q....ss.t.....Lp....-...p...h....LpN.to.hE.h.c.hLcs.......plpph.+..c.....pp.....p.h.....tp..c..p...ch.....l.cs.ppp.............up....s...p.tpW.hh.GhpCYYF............................................
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