GenomeNet

Database: Pfam
Entry: M11L
LinkDB: M11L
Original site: M11L 
#=GF ID   M11L
#=GF AC   PF11099.9
#=GF DE   Apoptosis regulator M11L like
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   PRODOM
#=GF GA   26.90 26.90;
#=GF TC   26.90 28.00;
#=GF NC   26.80 26.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   17384234
#=GF RT   Structure of M11L: A myxoma virus structural homolog of the
#=GF RT   apoptosis inhibitor, Bcl-2. 
#=GF RA   Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM; 
#=GF RL   Protein Sci. 2007;16:695-703.
#=GF DR   INTERPRO; IPR021119;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Apoptosis regulators function to modulate the apoptotic cascades
#=GF CC   and thereby favour productive viral replication. M11L inhibits
#=GF CC   mitochondrial-dependant apoptosis by mimicking and competing
#=GF CC   with host proteins for the binding and blocking of Bak and Bax,
#=GF CC   two executioner proteins [1].
#=GF SQ   21
#=GS A0A223FN70_9POXV/14-164  AC A0A223FN70.1
#=GS Q07036_VAR67/77-249      AC Q07036.1
#=GS Q9Q959_RFVKA/5-160       AC Q9Q959.1
#=GS Q85295_9POXV/6-163       AC Q85295.1
#=GS Q85295_9POXV/6-163       DR PDB; 2O42 A; 6-138;
#=GS Q85295_9POXV/6-163       DR PDB; 2O42 B; 6-138;
#=GS Q85295_9POXV/6-163       DR PDB; 2JBX B; 6-129;
#=GS Q85295_9POXV/6-163       DR PDB; 2JBY A; 6-128;
#=GS Q85295_9POXV/6-163       DR PDB; 2JBX A; 6-131;
#=GS A0A3F2YKH3_SHEVT/9-170   AC A0A3F2YKH3.1
#=GS A0A220T681_9POXV/10-165  AC A0A220T681.1
#=GS Q6TUZ5_YMTV5/12-171      AC Q6TUZ5.1
#=GS A0A1L3IZC6_9POXV/5-181   AC A0A1L3IZC6.1
#=GS G3EI97_9POXV/27-178      AC G3EI97.1
#=GS Q9DHU6_YLDV/12-173       AC Q9DHU6.1
#=GS Q1HTP9_9POXV/88-236      AC Q1HTP9.1
#=GS DPV22_DPV83/12-174       AC Q08FX8.1
#=GS DPV22_DPV83/12-174       DR PDB; 4UF3 A; 12-138;
#=GS DPV22_DPV83/12-174       DR PDB; 4UF2 A; 12-138;
#=GS DPV22_DPV83/12-174       DR PDB; 4UF1 A; 12-137;
#=GS U5TC42_COWPX/85-258      AC U5TC42.1
#=GS Q77G99_SWPV1/12-164      AC Q77G99.1
#=GS A0A097IVN9_9POXV/38-154  AC A0A097IVN9.1
#=GS A0A1B1MRB1_9POXV/41-216  AC A0A1B1MRB1.1
#=GS M11L_MYXVL/6-163         AC Q77PA8.1
#=GS Q8QN17_CWPXB/68-249      AC Q8QN17.1
#=GS F1_VACCT/47-224          AC Q9JFF2.1
#=GS F1_VACCW/47-224          AC P24356.2
#=GS Q0NPH0_9POXV/134-307     AC Q0NPH0.1
A0A223FN70_9POXV/14-164             ....................................s-KAIKYYINKQMLDNEFKSLSSSSKEFLKVISKKCNKINTDYRWD---ICDYIDSTHISV.DE....-LVSEINNTIRDNeSSIGIRLASISLISKM..........CDKWGQCQNT---Q.DLIY.R..MSD.SISDN-KAFIKYMQLVHSYNTTQKYILG.......-----...----.---...-------gscilgsilvackvfnf.................
Q07036_VAR67/77-249                 ....................stnildylsterdhvmm--AVQYYMSKQRLDDLYRQLPTKTRSYIDIINTYCDKVNNDYNRDMNIMYDMASTESFTV.YD....-INNEVNTILMDN.KGLGVRLATISFITELgkrcmnpvetIKMFTLLSHTICDD.CFID.Y..ITD.-ISPPDNTIPNISTRE------------.......YLKLI...GITA.IMFa.tYKTLKYM..................................
Q9Q959_RFVKA/5-160                  .....................................KEVVYTYLNGGDI------TECTEIDLLCQLVNCCNFINNTYAKNYDVLCDIME-RDILS.YNi..eNIKKALGFALL-D.ASPSVKLATLALLSII..........LKKLNKIRHT--EA.CVFS.D..VID.GITAEENKVIGFIQEKYKYNTTYYNKRSkl...pvYLSTA...MVAT.LIV...YGVIKWR..................................
Q85295_9POXV/6-163                  .....................................KTAVYDYLNDVDI------TECTEMDLLCQLSNCCDFINETYAKNYDTLYDIME-RDILS.YNi..vNIKNTLTFALR-D.ASPSVKLATLTLLASV..........IKKLNKIQHT--DA.AMFS.E..VID.GIVAEEQQVIGFIQKKCKYNTTYYNVRSggckisvYL-TA...AVVG.FVA...YGILKWY..................................
#=GR Q85295_9POXV/6-163       SS    .....................................HHHHHHHHCT--T------TS-TTHHHHHHHHHHHHHHHHHTHHHHHHHHHHHH-HHHHT.T-H..HHHHHHHHHHTT-T.--HHHHHHHHHHHHHH..........HHHHHTTS-----G.GGGH.H..HHH.HHHSSHHHHHHHHHTCHHHHHHHHHTTXXXXXXXXXX-XX...XXXX.XXX...XXXXXXX..................................
A0A3F2YKH3_SHEVT/9-170              ....................................e-KVLNVYLRDLRI----ESLNNNELEILIMIRECCEVIKKDYKTEFNEICNFILQNNVKScYDi..nDVKNIIIETINSD.FRPSVILASISLLSII..........IKKKKDENNEVVDDdLALN.E..LIN.KFSSYQKDIISFVEKNKKKNKQNDFIFS.......IINFF...VIVGsIII..tYYLLKI-i.................................
A0A220T681_9POXV/10-165             .....................................KNVLKYYLDEKILESQYESLNNIELYTLSYMRPFCDKIIKNHIKEFNNMYESLKL--SKD.IN....NI-NALTKLLKSN.KQIPAKIAAIAFTAVL..........VNKLTKYHS-ITDA.QSLS.Y..CVScDMSLDSEKILNFINCKNSSKFKKSIFKT.......I-SIL...CIGT.GII...YYY----ltit..............................
Q6TUZ5_YMTV5/12-171                 .....................................KDVIVFYINEKALIGRKKSLSNYENKLLNLIKKNCESILLNYKYNLINICDTLKVNDYTE.ENi..eRIKSQIIESLNND.NRPSVKLAIVSLVSMI..........AELHGYKNQNILMS.ALID.D..IAS.KISENSEDLIRFVKRDKQKNIFESVTC-.......---VF...GLLS.ILCl.lYYAVKG-r.................................
A0A1L3IZC6_9POXV/5-181              idmykvlhmyirrmsiqyilmkkilieceknnkytfi------------------NLNDEENDMLIMLESTCNSILSEYCSMFNDIKKIMNDIQNNE.SDi..dFLTKELNKLLS-T.GSIGIKFSVLSFIL-L..........CSKYPNVYNI-CPS.DVIDvN..MLK.KLSDNKSEIIRFVKKK--NINNNCNLLN......tFIK-F...CCIS.VAV...YFILK--ki................................
G3EI97_9POXV/27-178                 ....................................s-NAIKYYINKRVLDSEYALLTSSSKEFLKVITKKCNKISTDYRLD---ICNYIDPNRISI.DE....LVNEVVKNITINK.NSIGIRLASISLVSNI..........CSKWGQCVTT---Q.ELVC.K..MTD.-VIADSKQFTKYIKLYKYYNTKNNYII-.......-GSIL...VIGG.III..tFKVF---nfl...............................
Q9DHU6_YLDV/12-173                  .....................................KNVIVFYINEKALIEEKKMLSCYENKLLNLIKEDCENIMLKYKPNLSYICSLLKVDDTSE.ENi..kHIKDQIIESLEND.NRPSVKLAIISLISMI..........VEMNGYKGKNIPMS.FLIE.D..IAL.KISENSEDLINFINIKNKQKSFILKKVS.......YL--F...WWVS.ILCllgY------fikni.............................
Q1HTP9_9POXV/88-236                 .....................................RNVLFIYLQECLLRGMRRSLSDSDTELLEAIERSCSIIDSRYRASMDSMVDAVD---ASA.RD....LVMSTVRRGIQSD.S-HGESMATLALCSSV..........VERWARDGMTGRAL.DLTE.D..IVE.TVNPDS----------------------.......-----...----.---...-------lreaathiaqgpannrlgamafglvtvmiygaat
DPV22_DPV83/12-174                  .....................................KKLLNIYINDICTMGEKRLLNNYEKSILDRIYKSCEYIKKNYELDFNSMYNQININDITT.SD....-IKSKIIESLLID.SRPSVKLATLSFISLI..........AEKWGEKNRTKIME.ILSN.E..IVE.KISNNGKDFIDFIDRDDDDIVDDYVLIT......nYLKITifgAILG.ITA...YYICKYL..................................
#=GR DPV22_DPV83/12-174       SS    .....................................HHHHHHHHHHHHHHHHHHTS-HHHHHHHHHHHHHHHHHHHHTHHHHHHHHHHHSSST--H.HH....-HHHHHHHHHHH-.--HHHHHHHHHHHHHH..........HHH-SSS-THHHHH.HHTT.H..HHH.HHHTTHHHHHHHHTXXXXXXXXXXXXXX......XXXXXXXXXXXXX.XXX...XXXXXXX..................................
U5TC42_COWPX/85-258                 ...................kstnildylsterdhvmm--AVQYYMSKQRLDDLYRQLPTKTRSYIDIINMYCDKVNNDYNRDMNIMYDMASTESFTV.YD....-INNEVNTILMDN.KGLGVRLATISFITELgrrcmnpvetIKMFTLLSHTICDD.CFVD.Y..ITD.-ISPPDNTIPNTSTRE------------.......YLKLI...GITA.IMFa.tYKTLKYM..................................
Q77G99_SWPV1/12-164                 .....................................RNVLYVYLKYNTI----NKLSRYERMIYTKIKNQCEAIKYRYCNDFNSVTCILEYDENKY.ID....NVHKEVISILLSD.SRPSIKLAAISLLSII..........IDKL-ICRNIRIAK.YIID.D..IIN.IISEDGIYIILFLDEFDKYTDTRCRRRG.......L--SM...MIAS.IVT...YYCLRYV..................................
A0A097IVN9_9POXV/38-154             .................................yeli------------------NLNDNENDILNMLDSTCNTILSDYSFMFNDIKKNLN--NIQY.YDnnneFLRKELDNLLN-S.GTIGIKFSVLSFIL-L..........CSKYPNIYNICPSD.IINI.D..TLK.KISENKIEIINYVKKKR-----------.......-----...----.---...-------k.................................
A0A1B1MRB1_9POXV/41-216             ...................neldesyfiqsdkcdlyl--ALSLYIKEKELQGLRGALSPNAEALYKAIKNTCDKTDVQFNAAFRFIENMVDEENIMN.TS...dTYNSFVEDLTTQT.LTPGKAIATVTLWGRM..........FSKWCEHGYV-VRS.AAIS.QplIIK.LLNASPSNLQRFIQDYSK-INNKFNYG-.......FL---...----.---...-------aatiaagtvvflgikcf.................
M11L_MYXVL/6-163                    .....................................KTAVYDYLNDVDI------TECTEMDLLCQLSNCCDFINETYAKNYDTLYDIME-RDILS.YNi..vNIKNTLTFALR-D.ASPSVKLATLTLLASV..........IKKLNKIQHT--DA.AMFS.E..VID.GIVAEEQQVIGFIQKKCKYNTTYYNVRSggckisvYL-TA...AVVG.FVA...YGILKWY..................................
Q8QN17_CWPXB/68-249                 ...........enmvyrfdkstnildylsterdhvmm--AVQYYMSKQRLDDLYRQLPTKTRSYIDIINMYCDKVNNDYNRDMNIMYDMASTESFTV.YD....-INNEVNTILIDN.KGLGVRLATISFITELgrrcmnpvetIKMFTLLSHTICDD.CFVD.Y..ITD.-ISPPDNTIPNTSTRE------------.......YLKLI...GITA.IMFa.tYKTLKYM..................................
F1_VACCT/47-224                     ...............yrfdkstnildylsterdhvmm--AVRYYMSKQRLDDLYRQLPTKTRSYIDIINIYCDKVSNDYNRDMNIMYDMASTKSFTV.YD....-INNEVNTILMDN.KGLGVRLATISFITELgrrcmnpvktIKMFTLLSHTICDD.CFVD.Y..ITD.-ISPPDNTIPNTSTRE------------.......YLKLI...GITA.IMFa.tYKTLKYM..................................
F1_VACCW/47-224                     ...............yrfdkstnildylsterdhvmm--AVRYYMSKQRLDDLYRQLPTKTRSYIDIINIYCDKVSNDYNRDMNIMYDMASTKSFTV.YD....-INNEVNTILMDN.KGLGVRLATISFITELgrrcmnpvetIKMFTLLSHTICDD.YFVD.Y..ITD.-ISPPDNTIPNTSTRE------------.......YLKLI...GITA.IMFa.tYKTLKYM..................................
Q0NPH0_9POXV/134-307                ...................kstnildylsterdhvmm--AVQYYMSKQRLDDLYRQLPTKTRSYIDIINMYCDKVNNDYNREMNIMYDMASTESFTV.YD....-INNEVNTILMDN.KGLGVRLATISFITELgrrcmnpvetIKMFTLLSHTICDD.CFVD.Y..ITD.-ISPQDNTIPNTSTRE------------.......YLKLI...GITA.IMFa.tYKTLKYM..................................
#=GC SS_cons                        .....................................HHHHHHHHCCHHCHHHHHTTSHCCHHHHHHHHHHHHHHHHHTHHHHHHHHHHHCSCCHHC.CHH..HHHHHHHHHHCCHT.--HHHHHHHHHHHHHH..........HHHHCTTSTHHHHH.HHCC.H..HHH.HHHTTHHHHHHHHCTCHHHHHHHHHTTX......XXXXXXXXXXXXX.XXX...XXXXXXX..................................
#=GC seq_cons                       .......................................sl.hYlscppL.s.hcpLsspppshLshIpppC-pIsscYspshs.hh-hhs.pshss.h-.....IpsplsphLhss.ps.uV+LAolShlo.l..........lc+ashhspThhss.shls.p..ls-..ISssspplhsalp+c.........hh........al.hh...slsu.lhh...YhhlKh...................................
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