GenomeNet

Database: Pfam
Entry: MPS2
LinkDB: MPS2
Original site: MPS2 
#=GF ID   MPS2
#=GF AC   PF17060.6
#=GF DE   Monopolar spindle protein 2
#=GF AU   Llagostera M;0000-0001-8177-8321
#=GF SE   Manual
#=GF GA   28.00 28.00;
#=GF TC   29.40 29.10;
#=GF NC   26.70 27.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   1869587
#=GF RT   MPS1 and MPS2: novel yeast genes defining distinct steps of
#=GF RT   spindle pole body duplication.
#=GF RA   Winey M, Goetsch L, Baum P, Byers B;
#=GF RL   J Cell Biol. 1991;114:745-754.
#=GF RN   [2]
#=GF RM   9060463
#=GF RT   The yeast CDC37 gene interacts with MPS1 and is required for
#=GF RT   proper execution of  spindle pole body duplication.
#=GF RA   Schutz AR, Giddings TH Jr, Steiner E, Winey M;
#=GF RL   J Cell Biol. 1997;136:969-982.
#=GF RN   [3]
#=GF RM   10397772
#=GF RT   Saccharomyces cerevisiae MPS2 encodes a membrane protein
#=GF RT   localized at the spindle pole body and the nuclear envelope.
#=GF RA   Munoz-Centeno MC, McBratney S, Monterrosa A, Byers B, Mann C,
#=GF RA   Winey M;
#=GF RL   Mol Biol Cell. 1999;10:2393-2406.
#=GF RN   [4]
#=GF RM   10654940
#=GF RT   The Bbp1p-Mps2p complex connects the SPB to the nuclear envelope
#=GF RT   and is essential for SPB duplication.
#=GF RA   Schramm C, Elliott S, Shevchenko A, Schiebel E;
#=GF RL   EMBO J. 2000;19:421-433.
#=GF RN   [5]
#=GF RM   12399372
#=GF RT   Mutant membrane protein of the budding yeast spindle pole body
#=GF RT   is targeted to the endoplasmic reticulum degradation pathway.
#=GF RA   McBratney S, Winey M;
#=GF RL   Genetics. 2002;162:567-578.
#=GF RN   [6]
#=GF RM   11952896
#=GF RT   Spc24 interacts with Mps2 and is required for chromosome
#=GF RT   segregation, but is not  implicated in spindle pole body
#=GF RT   duplication.
#=GF RA   Le Masson I, Saveanu C, Chevalier A, Namane A, Gobin R,
#=GF RA   Fromont-Racine M, Jacquier A, Mann C;
#=GF RL   Mol Microbiol. 2002;43:1431-1443.
#=GF RN   [7]
#=GF RM   16923827
#=GF RT   The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to
#=GF RT   connect the spindle pole body with the nuclear envelope.
#=GF RA   Jaspersen SL, Martin AE, Glazko G, Giddings TH Jr, Morgan G,
#=GF RA   Mushegian A, Winey M;
#=GF RL   J Cell Biol. 2006;174:665-675.
#=GF RN   [8]
#=GF RM   16436507
#=GF RT   The Saccharomyces cerevisiae spindle pole body (SPB) component
#=GF RT   Nbp1p is required  for SPB membrane insertion and interacts with
#=GF RT   the integral membrane proteins Ndc1p and Mps2p.
#=GF RA   Araki Y, Lau CK, Maekawa H, Jaspersen SL, Giddings TH Jr,
#=GF RA   Schiebel E, Winey M;
#=GF RL   Mol Biol Cell. 2006;17:1959-1970.
#=GF DR   INTERPRO; IPR031433;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Is a fungal transmembrane protein which is part of the component
#=GF CC   of the spindle pole body (SPB) required for the insertion of the
#=GF CC   nascent SPB into the nuclear envelope and for the proper
#=GF CC   execution of spindle pole body (SPB) duplication
#=GF CC   [1,2,3,4,5,7,8]. It seems that Mps2-Spc24 interaction may
#=GF CC   contribute to the localisation of Spc24 and other kinetochore
#=GF CC   components to the inner plaque of the SPB [6].
#=GF SQ   38
#=GS J7R7M3_KAZNA/11-97        AC J7R7M3.1
#=GS A7TJ40_VANPO/12-281       AC A7TJ40.1
#=GS G8BU01_TETPH/12-421       AC G8BU01.1
#=GS S6E1Z8_ZYGB2/12-338       AC S6E1Z8.1
#=GS J7R7M3_KAZNA/133-315      AC J7R7M3.1
#=GS A0A1X7R0H8_9SACH/107-337  AC A0A1X7R0H8.1
#=GS H2AS67_KAZAF/4-85         AC H2AS67.1
#=GS MPS2_ASHGO/142-337        AC Q755A9.2
#=GS G8JP53_ERECY/9-101        AC G8JP53.1
#=GS MPS2_ZYGRC/12-339         AC C5E006.1
#=GS I2GV48_TETBL/115-345      AC I2GV48.1
#=GS MPS2_KLULA/35-143         AC Q6CS73.1
#=GS H2AS67_KAZAF/79-253       AC H2AS67.1
#=GS A0A1G4M9N3_LACFM/11-385   AC A0A1G4M9N3.1
#=GS G0WFX0_NAUDC/17-365       AC G0WFX0.1
#=GS G8JP53_ERECY/97-211       AC G8JP53.1
#=GS W0T3U6_KLUMD/7-118        AC W0T3U6.1
#=GS W0T3U6_KLUMD/107-290      AC W0T3U6.1
#=GS A0A1G4K2Z7_9SACH/12-393   AC A0A1G4K2Z7.1
#=GS J6EIH2_SACK1/12-388       AC J6EIH2.1
#=GS A0A0A5HYD7_9BACI/34-178   AC A0A0A5HYD7.1
#=GS MPS2_ASHGO/49-132         AC Q755A9.2
#=GS A0A1G4KAS6_9SACH/11-397   AC A0A1G4KAS6.1
#=GS A0A109UZH0_9SACH/102-300  AC A0A109UZH0.1
#=GS I2GV48_TETBL/11-126       AC I2GV48.1
#=GS A0A0C7NAD6_9SACH/12-389   AC A0A0C7NAD6.1
#=GS A0A1G4JRV9_9SACH/12-389   AC A0A1G4JRV9.1
#=GS G0VEG7_NAUCC/14-352       AC G0VEG7.1
#=GS MPS2_LACTC/11-385         AC C5E2E7.1
#=GS MPS2_CANGA/11-354         AC Q6FS52.1
#=GS MPS2_YEAST/10-386         AC P53159.1
#=GS A0A0H5C2G6_CYBJN/6-319    AC A0A0H5C2G6.1
#=GS A0A1X7R0H8_9SACH/8-111    AC A0A1X7R0H8.1
#=GS G8ZVW5_TORDC/12-322       AC G8ZVW5.1
#=GS K0KII0_WICCF/26-318       AC K0KII0.1
#=GS A0A2B4SPK6_STYPI/299-498  AC A0A2B4SPK6.1
#=GS MPS2_KLULA/132-320        AC Q6CS73.1
#=GS A0A109UZH0_9SACH/10-102   AC A0A109UZH0.1
J7R7M3_KAZNA/11-97                   .....................................LNYLWGEVDPL.NKGFIYGRDFPEFIRELHRLLPPQ-----............--HLSTTYDTALIGNFGKEHNTEKIYKVILDDYLEGLIGTSFSEFVKK----........................--..------...-----------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------nqislp.........................................................
A7TJ40_VANPO/12-281                  .....................................LDIAWSELDNG.DQGFIYAKDFPNFIHIIENIIYKSQDSNE............-RALLSETGKGVISTFAKEKAFFKIYKDEFKEIFHGLIGKSFNESLKGTFKS........................-G..NIQTDM...CPEKGLENPEI...............................M--GKNKPSNSN.......AFNS-I....QDNA-KSSV...LESP.RKL.NRKLKGLENQISLANDELKFKDNIIIEKDREIIQLTRSLG....EYKDKYEFLQREFS.FYKDRGEFNKKY..Qdmnninq..........aqnmddiIMDHTKHEFIISELKRKLQDQLETIGALREELHGDSN-.......-TTK..R-.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------sfyypvysn......................................................
G8BU01_TETPH/12-421                  .....................................LDVAWAELDNK.NQDFIYAKDFPNLVNIINNFLNRSSNDGS............KHTLLSSTGESVINTFAKEKEFFKIYKDEFKEIFYGLIGKSFKELVNESIN-........................--..---FGE...IDISHLKENVKmskkgdqespyrhendhahhilnnsssniynS----SADNVQTkiygndeSNDESI....LKLKENENI...IESP.LRN.LSYKRELENDLLITKKDLKFKDDIIMEKDREIIELTRKVG....DLKDKYNFLQREFS.FYKKRGENRNSL..Ttdddktn.........detnlniqKNDVTKHEFIIDEMNRRIHEQMLIINALKEELQNDNPNgnskfgyLYNS..MR.KQ.LS..RNP.................SYSS.TL-Y.V.IISIFFFLS....IVV...ISGSTIFTSF.....SQDD.....RMGAYdsyrykylesFGA.SWWEQNTLLRFIMnLFFGKG.TEPYEF..SdpYVTT....AASSN....AYDNLF-n..............................................................
S6E1Z8_ZYGB2/12-338                  .....................................LDLAWSDVDRK.NQDFIYAKDFPALIRSIEKILNRG--KPE............ELPLLSNTGKSVIDTFAKEKEFFKIYRDEFKEIFHGLVGKTFKDAIEMA---........................--..NAPGQL...SAGSVLQDT-Q...............................PSKPQEA-----.......------....--VKSNKSS...PRKA.---.NRLLRNLENRVSTMKEELKFKDDILAEKDRELIQLTRKLG....EYKDKYEFVQRQFN.FYKDHGESPKRS..Sses.................snmeQNASTKHEFIISELKRKLQEQTLAISTLREQLHRTEGAg.....aFYSK..SA.--.--..KDM.................NLND.WPKA.M.TAFLLLASL....VIL...LFGGLLWLTS.....GSED.....STSFA..........-QP.SWWEKNGVLSRIG.WFIRDW.STN-SV..D..YVDF....EPSSD....AYDRIMG...............................................................
J7R7M3_KAZNA/133-315                 ...........................eknsipqtel-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....---------...----.---.----------------------------------------....-YKLKYEQLKSEYE.FYKKRTAEDTWK..R........................QGASLNDEYILHEFRKQVNEQSDIILKLKSQLDRREPVkl...qdP-QE..SD.NR.NE..PSGer.............yqRGVQ.KLRT.Y.IKYIALPLL....LWA...IIHFAI-LPS.....DQDD.....IDMAP..........YQLeNWWEKIPLLNGLV.SYFSDI.LNDYAE..P..SVSP....SHMSAenieAYNEIFG...............................................................
A0A1X7R0H8_9SACH/107-337             .................................dkdn-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....---------...----.---.---------ELEILKQQLREKDILIKSKDDKLDALQENVE....LFKKKYDHLVDEFK.YYKKTIGKQKQL..Sqemntnsed.....sisneenvenRNFDVRNEFFIEEFRRQINEQSRVINKLKDQIQNNPAIsgy.nssKDKQ..KK.TF.LW..NNI.................PVF-.----.I.SKQFTSFLM....IISilgFISSLYFRFT.....ASDDslllgINSNN..........SEE.SWFSNNPLISSID.WLVGEKaSENRDT..E..LGSYremtEQDIE....AYNKIF-s..............................................................
H2AS67_KAZAF/4-85                    ....................................v-DKYWDQIDVK.SRDHIYGNELPKLINSVK-----G-----............KDILLNDTKLNVIKQFANDKPFHKIYKLVLDQFLDDLIGVTFTQLVA-----........................--..------...-----------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------tdknd..........................................................
MPS2_ASHGO/142-337                   ........................irrasatgdeqar-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....---------...----.---.----------------------EELERKSAELSRVRDELD....EWKSKYQFLEREFL.FYQTHHENS-V-..-........................--DSTQHEFIISEMKRTIEEQTRMIGQLRRQVQGGTQVl.....aRAGK..RA.SP.VD..VFMy...............vSRQG.LLLL.M.RMPKAAFLL....LLL...GYFVWYTVMGga.vqGPDP.....SVALPe........pPKQ.PWWEQNNIISALY.WYLTDT.FEP--S..Q..RIN-....DTVND....NYNSLFG...............................................................
G8JP53_ERECY/9-101                   .....................................LNAAWDIIDSK.HQGFIYAKDIPELIRRLNTFVTHN-----............---LTTKANDEVISSFAKEQPFLKLSKDEFKAKFQSLVGTGIQTAVEM----........................--..------...-----------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------anmsdtkprlfgs..................................................
MPS2_ZYGRC/12-339                    .....................................LDLAWNQVDKK.NQDFIYAKDFPALIMSIEEILSRG--QQT............PLAFLSNTGKSVIDTFAREKEFFKIYRDEFKEIFHGLVGKTFK---------........................-D..TIEGTN...VSRSVLDEQ--...............................---GQEPDVSTT.......PTRQ--....-----QRSS...PRKV.---.NRLLKNLETRVASMKDELKFKDEILAEKDRELIQLTRKLS....DYKDKYEFVQRQFS.FYKDHGESPRRN..Ssese...............qlnleQNASTKHEFIISELKRKLQEQTLAISNLKEQLQRGEGAgv..lytNYSK..RY.NP.LH..NDG.................PMVL.VL--.-.--ATLVFLT....IIL...LIGSMIWVTG.....GKDD.....SNSFS..........-QY.SWWENNSLLSRIG.WFFRDW.SDT-GV..D..YVNF....EPSSD....AYERIMG...............................................................
I2GV48_TETBL/115-345                 ............................spirlgkpy-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....--------S...PSLP.KSVeSKNLKTLQYENNSLILEIEEKNHMIRQ-------LKDSLI....ELEGKYTYLENELK.YYKNNTHSKFNQlhS........................EVDNEEKDFLLLELKKILQEQNVLIEKAKKNNKSRLKS.......QTLP..SL.SK.LQ..QQRnfndicfsckdffgyylSQEN.FLNY.I.LPITILILL....IC-...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------fykflnclslsgnvenesiinhievdsspikrlfnylfikekvrdsemfednssklaydrlig
MPS2_KLULA/35-143                    .....................................LDRAWSVLESG.SDGYVYAKDIPEIISFIDRELP-------............-SKLTTQSNDKVIESWVNNDPMKTLSKEQFLEAFSMLVGTSFDTAVQIAM--........................--..------...-----------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------qsdiltptrrgaslfgsyrrssndleq....................................
H2AS67_KAZAF/79-253                  ..................................vat-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....---------...----.---.-------------------DKNDDMKEKEQEILRLNEKIN....YYKEKFEIIEKEFK.FYKETVEKRSRD..G........................SSSDVDNEFIIIECRKQLAEQSKLIANLQKYVNNN--N.......NHAT..RN.SG.IK..QTK.................ESIL.NPNI.K.SFIILCGIT....LIL...VVILLYYVF-.....----.....-TAIT..........--W.SNIDGTSFISRIV.WNVHDF.STSNNY..K..MSE-....-QDIE....AYNKIFG...............................................................
A0A1G4M9N3_LACFM/11-385              .....................................LDHTWPLIDTK.GQGFIYAKDFPLLLSKMQEVLNRGKPTHK............QVSLISKTGHEITRKFANDQEFFKVYKDDFKVLFDGLIGMSFKAAVDSCTDDgtleklr..........gtlswqsAG..HVDESL...ISGETILERQKpl..........................pdqSNKENRRDITGE.......AVPPDAkepaANPGNPRDS...LLGS.PAS.IRRVRNLQVDVESLKEEVLFRDEIIREKDRELLDLTKKVS....DYKDKYEFLEREFQ.FYKDHAETKAVG..N........................SPDTTKHDFIIAELRRKIEEQTGMISQMKAQMPSESDA.......PFRG..AM.ES.TQ..TKI................vPLHV.IL-K.A.LGLCIVFLLssylVIS...VVRLMADSAG.....ELSS.....VATRG..........VHL.EWWEKSSLLSKMR.WFFTDA.FDELGG..N..ALYN....EGMND....NYDKVFG...............................................................
G0WFX0_NAUDC/17-365                  .....................................FNEIWNSCDIK.NQGFIFADELTNLFEF---------NKDK............FIRPLSTHESNLIQQFSSQDPTYKITKNDVNNVLKKLVNFTIFQMLKPTTSV........................GP..PIENGK...EPIGKNDAN--...............................--TKDKQNIIVS.......PSNT--....----SNNNS...PKKK.---.--KNPNLIAEINNLTRQLGIKDNIISEKQLLIDDLKENVE....TYKRKFQFLQKEFL.FYKENVGKKYSS..Nysqys.............lsehdgIK-DPKQDFLLSEFKRQIQEQKSIIQRLQERIELKKPFniptnidN---..--.SI.IS..NNErkk...........hsgIISS.LSNF.L.FPYLLPILT....FSL...SVIFLVIFYL....fNSKD.....NASIE..........WEL.SWWERSNWLSSLG.WSLKDM.LSI---..-..----....-----....-------ftftpdnasnnnimndkeafdaymra.....................................
G8JP53_ERECY/97-211                  ...............................rlfgsi-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....---------...----.---.---------RRSSIKGEETSKEEHMR-KNLELEKLRGEIE....DWKSKYQFLEREFL.FYQTHHENLV--..-........................--DSTQHEFIISEMKRTIEEQTRVIDTLKCQMQGKDIV.......MVSK..G-.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------nhryreafilhqtd.................................................
W0T3U6_KLUMD/7-118                   .....................................LDRAWSLLDGE.KRGYIYANDIPNLIGFISNEL--------............PSKLTTSSNDKVIESWISSDPMKRVTKEEFKQVFSMLVGTSFDAAIEMAKE-........................--..------...-----------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------sevftpnrrgsglfgsyrrssndslpdta..................................
W0T3U6_KLUMD/107-290                 ...........................rrssndslpd-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....---------...----.---.---------------------------TAEQLQSLKRELQ....EWKDKYGFLEREFQ.FFLAQEKKNAKV..-........................-IDNTKHEFIIGELNRKLAEQDEAIRDLKQQLDYGLVA.......---K..PI.KK.WI..NTK.................FLITaFLHL.L.PKALFLFVI....VVL...GCYVIPLISL.....TKRP.....VAVPAsp......fmRQE.SWWERSSMLSRIQ.WYFKDR.MEN-NI..E..RNTS....EL-MQ....NYNSVFG...............................................................
A0A1G4K2Z7_9SACH/12-393              .....................................LDQVWPSLDNR.EIGYIYAKDFPLAVSKMEELLRKANPKGE............KQTLVSKAGEEIIKKFGTDQEFFKVYKEDFAELFDGLIGHSFASAVDRCCREgg....................sdIS..RINRES...ISFRDNEETPVeaellreel............laikqeltmvKGENVDKDQAIA.......ARDAII....ADLRQKKHTsdvPSTSsPSG.MLRSTKLQAQVARLQEDLRTQVNVIRDKDRESLDLARELD....DLKDKYQFLEREFQ.FYKDHGEGQKPA..S........................AKEATKHEFIILELRRKIEEQSDMIAAMRQQVESKYFSip...amNSGT..VE.SG.IL..SFV.................PISR.ILRS.F.IGVVLLVIV....VRL...FWAVLFGAAAv...fNSDE.....AQALNs........kIDF.EWWEQSSLLSKMH.WYFTDR.FES-GW..G..PASD....EVLDA....NYNKVFG...............................................................
J6EIH2_SACK1/12-388                  .....................................FEYAWGQIDKPiSGDFVYGKDLPKLIGIIEDIFREAQKDGSy.........dlRLPLFPEINKELFRTFSNTKTFFKIHKEDFDDIFFNLVNTSLKEVLEKAFNG........................LN..SIPGNF...MASLNLNLLSK...............................SS-NENKDSNIQ.......EPEA-L....TPQEKLIDS...PISL.LNK.YNTGNTLKVQVEELQKELNMKQSLLLENERQAKELRKRLE....TYQQKYASIQQQFNdLQKNMQAEGNRN..Isett...............nsdppLVARIDQEAILEEFKKRLQRQTDTISSLKDQIRRERGL.......NYND..NKaAP.LG..RKYstfedgss.lknfgdmfPSYL.WVKA.I.LKAILCFVL....IT-...GILSYAAKYL....yVPDT.....PSQNS.........rLQL.SWWESSGIISKIV.WFFQDQ.TDL-ET..E..YSSN....VKIDD....AYSKVFG...............................................................
A0A0A5HYD7_9BACI/34-178              .....................slivatiagvnvfeaa-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................----QKYSSQIP.......VISSII....PDQDEKESS...EAGS.PEL.KAELEDKKAQIQSLQNELTSKDKTIEELNKEITDLTNQLAakneSKKERDQLLKKIST.SFKE--------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------mdaeqaapivanldqnvaialleslpdeerglifaem..........................
MPS2_ASHGO/49-132                    .....................................LNNVWDAVDSK.QQGFIYAKDMPDLVGRFGQFLAQS-----............---LTSRANDEAIAAFASEKPFYKLDKEQFKSTFQTLVGTSLQTAVE-----........................--..------...-----------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------laghg..........................................................
A0A1G4KAS6_9SACH/11-397              .....................................LERAWPLVDVK.SQGFIYARDFPLLIGKLDEQVNAQRPAHR............RTELVSKTGRDILTKFATDQEFFKVYKEDFKDLFNGLVGTSFKAAVEKCAGE........................-E..TLNGAS...PTKSGICEA--...............................----ANRDAGIA.......ALKSHQ....IDDDCSPPS...SASA.MSS.FGRAQNHHDVVTALKRELQFQDEIIREKDRELLRLTKRAS....EFQDKYEFLEREFS.FYKGHAEPHATT..RkrsvpsppasapapassafasqllLHDNTKHEFIIAELTRKIDGQRELILAMRAQLDAADSG.......-VSG..TR.RT.LH..SGSss............dppALSA.LCDR.A.HRAFAVFLL....LVV..pLFVCLRAWGAl...sTARD.....ANVGPrai....vegGAP.AWWENSAVLCRLR.WFVADV.FGQ---..-..----....-----....-------gapgvgsllrtrtaaldgpalasynrlfg..................................
A0A109UZH0_9SACH/102-300             .................................sirr-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....---------...----.---.-----------QSIAGDDQIKDELL-KKSMEIEKLQSEIN....DWKGKYQFLEREFM.FYQTHHKS----..-........................ISDSTQHEFIISEMKRTIEDQTKMISKLKLEIQGTPIKkp...siSTTK..SD.VL.RH..LSK................rGLVF.LLRSpR.IALAIAVLT....YMLw.yMIVSMS--AG....aNSSQ.....VGVYH.........pPSQ.SWWERSNVISAFY.WYLTDK.FESNQVinD..TVK-....DKVSA....NYN----iafe...........................................................
I2GV48_TETBL/11-126                  .....................................FDQVWLQVDSD.NKDFIYASELPQFLSLLNDKITRDTGIPK............RDILDPSSDMK-LQGFIKEQQYFKILKNSMIRTIMNITGIDLQSQLIDLYPSyf....................tiVD..TIPMPT...VSPIR------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------lgkpysps.......................................................
A0A0C7NAD6_9SACH/12-389              .....................................LDAVWPLVDVK.GTGFIYGRDFPLAVSKMEELLNKGHYDNS............KSTLVSKTGQEILKKFSSDQEFFKVYKDDFAELFHGLIGTAFRTAVQSCSREgwldfik..........tasetvsFN..DNEDTP...VEPETLRGEIAalks......................qigelRRQNAGKDKTIA.......TNEVLL....TELRNSGGS...PSAS.PTK.NAGTRSLRARISELLREVQARDEAIRYKDRELLSMTKKVG....EYRDKYQFLEREFQ.FYKDHGELQKPE..A........................TKEATKHEFIISELRRKITDQSDMINAMRSQVESKNPLvs...hpKPAG..VE.SS.II..DLV.................PVQK.ILKC.A.MAIIGIFIVa.nvLLY...FVAALKSVFG.....SSSA.....QGINP.........qIQL.NWWERSSMLSKIV.WYFSEY.FEQ-DW..S..IAAD....ENINS....SYNKIFG...............................................................
A0A1G4JRV9_9SACH/12-389              .....................................LDVVWQAIDVK.GTGYVYGRDFSLVVSKMEEILNKGRSGSE............RATLVSKTGEEILKKFSSDQEFFKVYKEDFCELFNGLIGTSFRNAVQRFTGNgsltflr..........nehqttsFY..DNEKTP...VDSEALREEVLalkr......................tiselQKWNSEKEHDIS.......SKNEVL....AELRQSNGS...PSGS.PMR.KVGSRTLEAQVATLKEELNFKDGIIREKDRELLSMTEKLE....DFKNKYEFLERGFQ.FYKDHGELQKPE..A........................IKEATKHEFIISELRRKIQDQSELIGAMRTQVESRKVA.......LPAM..RE.KS.VE..ASLpd.............lfSLST.VLKY.I.VGAIFLVLA....INI...LLYSMAFLKSl...iKLNP.....SQELNs........kIKL.KWWEQSSVLSKVH.WFFTDF.FEY-DW..D..PASD....EVLSA....NYDKLFG...............................................................
G0VEG7_NAUCC/14-352                  ....................................w-DHAWYQIDKE.RTNFIFAEDLPRLMKD--PIWN-------............--PLTAEQ-WANLEGFATDSPAFKIEKEKLNPIMLTAIGKSLDELLSVSHEE........................ND..---DHA...TSKVEMEPR--...............................TKTQSENDNNNN.......DKKI--....---RTKDA-...----.---.---RPNLISKLSELNKELHRKDEIIMQKQNVINGLIDNVN....LYKEKFEFLQREFT.FYKQHDTQKRKP..Qtnenvg............vnekgdRNVNLKHEFILSEFRRQVREQNQLIAKLKERINSNPDDa.....nAYLSspTP.NT.VN..EIK.................PAYI.SMWP.P.IIAVLLLLL....FII..ySLISYTNVSIpsllsSQED.....DSDFA.........rNQL.SWWERISWLSRMI.WSMKDY.LES-SS..S..SGNFp..iDREDD....AYNRVFG...............................................................
MPS2_LACTC/11-385                    .....................................LDLVWPEVDEK.AQGFIYAKDFPLVVSRMEEILNRGKLERD............RAQLVSETGREILRKFGSDQEFFKVYKEDFRELFDGLVGTSFKSAVKSCAGDgvldr.............lqdsqaVD..GIQDEK...TSSHALQEEVMrlre......................qvrvlSSKNDEKDREIT.......ARDEII....ADLQGKDAS...PAGS.PRS.LQRMRTLQARVTSLEDELSFRDEVIREKDRELLNLTKRVG....EFKDKYQFLEREFQ.FYKGHREQKSPD..S........................IKEATRHEFIISELRRKITEQSEIIGQMRMQVEAKPGA.......----..--.--.LH..PQGigsta......glplnlPLRL.VLRL.I.IGAILAYLA....FDI...GIRSLKAVGGl...fGSSS.....PATLTp........kSEL.SWWEQNTLLSKLL.WFFKDL.FDTYNL..D..AGRD....EVVSA....NYDKLFG...............................................................
MPS2_CANGA/11-354                    .....................................FERVWLQVDRD.RDGFIYAKQMPSFITQCEQVIKDTVNTNKtdfhmtrfknrlKLPLLPKLHMDLIDAFAKETPYYKIYKESFSDMLNKLTGNNFSTVINKIFED........................CD..GFPASF...ISALEVKADVK...............................SSPRSKADSLGS.......PIKVDL....LRNLKPQEE...PETP.RRI.NRKYKSLELQLESMKRELEDKEKTIMNNERNLTELRSTIS....KLKEKYDLLSEEYE.---QRHIHGGNN..G........................--TAIKHDVVIGELKSRLQEQNRLIRILQEQIQFD---.......PQLK..RE.TR.VH..DNK.................SKNN.TFNG.A.IAYVIPFLL....FIF...VIRSLI----.....TKED.....IGDAT..........MAL.PWWERNNLASRLA.WYFRDV.FSNDSA..K..FLE-....---SD....AYDKVFG...............................................................
MPS2_YEAST/10-386                    .....................................FEYAWGQIDKPiSGDFIYGKDLPKLIEIIENIFQKAQKSGSy.........elRLPLFSEINKDLFRTFSNTKTFFKIHKEEFDDIFFNLVNHPLREILENAFIG........................VD..SIPSDF...IVSMNLNSPSK..............................fLVENKNKNTEGA.......GIST--....-PRKKLTES...PIKL.LSR.NNIGKALEVQVEELKRELTAKQSLLQENERQVSELKIRLE....TYQEKYASIQQRFSdLQKARQVEDNQN..Ssrts...............dpgspLVTGIDQKAILEEFRRRLQRQTDTISFLKDQIRRERGLncsndkvSHSK..RK.HA.T-..--Tdgdgtf....knfisavPSNI.WVKA.T.IRIIVCFAL....LAG...VLPYIRKYVY.....AHDT.....PSQNS.........rLQL.SWWENSGILSKIV.WFFEDQ.TDL-ET..E..YRSN....ANVDD....AYSRVFG...............................................................
A0A0H5C2G6_CYBJN/6-319               ....................................l-TLSWRQVDRS.GNGYIPSLELPLLVDTVNKYL--------............KTPLINEEEMKTLKRFSQRDTHKRIYKSEFKTLFNSLVGLTFANALQLAQLD........................SK..AIEQDNdvgVENKRVDDDHSirpsfk...................kewrkyK-RLSETQEDEI.......KYRDDV....IRQLETKYS...NNDK.--L.IHETSTLVKQNEKYEEEISFRDKIILERDETIKQRDFKIQ....KLQEQVKSLNDEIS.LLKGKHPDELMR..F........................--QWGKEDKFHRELKSRIQKQQDTIDKLKQMLYSKKKF.......TTPK..DI.KE.QT..NKK.................GKNY.TKFV.L.IPFVSLVIC....LFL...QIQY------.....----.....-----..........---.-------------.------.------..-..----....-----....-------rrwveqywfemvdnadidyayyes.......................................
A0A1X7R0H8_9SACH/8-111               ....................................f-KNIWLELDGA.KRGFIYGKDLPNLVTK---ILNAS---ND............SIESIDKDKRELLETFAKEQPFTKIYKVVVDDTLKKLIGVTYADLVSNNDNN........................IDksSIPKRK...IS---------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------idkdne.........................................................
G8ZVW5_TORDC/12-322                  .....................................LDVAWGKVDKK.SQGFIYAKNFPQLIQAIELLLNKG--EPA............QLRLLSNTGKNVIDTFAKEKEFFKIYKDEFKEIFQGLVGKTFKDAVE-----........................-G..TFPSGK...IPKNVLQES--...............................-----KEDQ---.......------....----GIIDS...PQKK.---.DLRLKNLQNRIAALTEELQFKDDIIAEKDRELIKLTRGLS....EYKDKYDFLQRQFS.FYKDHGESPTNE..Epg....................anEPVSTRHEFIISEMKRKLQEQLLTINALREQMQQAQGT.......-YQW..YT.KP.LK..SNK.................IESA.PLIL.I.VLFTITLFS....LLF...YITKCF----.....VTDD.....QADRY..........YET.SWWEKSGLLSRLG.WRWQDW.KDS-TI..D..LPN-....---SQ....AYDKVFG...............................................................
K0KII0_WICCF/26-318                  ...............................vnslln-----------.-----------------------------............-AKILNSSGRTIVKDFSKTEPHHKINKSAFKSLFNSLLGTSFNNALEAITYDktllelekgdvsilpdipvltstpV-..------...------KKEPEdkfkpnf.................kteysklKKLHDNSEDEIK.......FRDEYI....EKLEKREIE...SEDS.---.TVKLRSLVKKISNLENEITYRDELIIKFQNELINEQEKHK....KSQNVIKLMENEIK.ELRNSSKSSDPS..Sss...................sssSSSSSNSKIFINALQERISKQQIAINHLKSTLQSKSEI.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------itktpiifstpnntskpeqmeglskiwrlvsylliiwltiytfinlyftgd............
A0A2B4SPK6_STYPI/299-498             seqfalamylihqkvmgvdppqtlqpemvppsvrsgs-----------.-----------------------------............----------------------------------------------------........................--..------...----------A...............................ASPTGGEDREGG.......AAGSV-....ISTLSDFSA...IKEL.DKI.TKEIEDLGREKTSLQHEIEEKEEMIRQRNGEIQNLQSELE....KTKLKYQELEKQKT.----DSQGKLDD..L........................DKEKAKLDEMLKDAKQKCEEETKTINGLQAQIASSRKS.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------alvrskvstleetnsslnaniahynslm...................................
MPS2_KLULA/132-320                   ...................gsyrrssndleqvlpaeq-----------.-----------------------------............----------------------------------------------------........................--..------...-----------...............................------------.......------....---------...----.---.-------------------------------IKALKRELQ....EWKDKYTFLEHEFQ.FFLSQ-EKKNPE..V........................-IDNTKHEFIISELNRKLREQDEAIEDLKSQLDYG-LV.......PELK..DK.TNwIKalQRK.................AYNY.LLPK.IlICLLLLLLY....YCL...AAKILFTKSS.....STDD.....VPSFI..........RQQ.SWWERNKILSRIQ.WYFKDR.IENNVV..R..NSS-....-EVIQ....NYNSVFG...............................................................
A0A109UZH0_9SACH/10-102              .....................................FNIAWNAVDEK.QHGFIYAKDMPELIQRLNTIANTS-----............---LTTKSNDEAILSYANQNPFYKLDKDEFNVKFQSLVGTSLNTAMEM----........................--..------...-----------...............................------------.......------....---------...----.---.----------------------------------------....--------------.------------..-........................--------------------------------------.......----..--.--.--..---.................----.----.-.---------....---...----------.....----.....-----..........---.-------------.------.------..-..----....-----....-------anfsdtkprlfgs..................................................
#=GC seq_cons                        ......................................p.hW..lD.t.tpsaIYup-hP.hlt.ht..h.......................Lhsptt.phlppFuppp.hhKl.Kpphpphh.tLlGhshpphlp.................................................................................................................................................t.h.tp.t.+pphl.ppptpl.pLppplt....ph+pKYphLpcpap.happptttt................................tshcp-hlltEh++plp-Qp.hItth+pplptt.............................................................hh.hh.....h.......................................................................................................................................................................
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