GenomeNet

Database: Pfam
Entry: MSA-2c
LinkDB: MSA-2c
Original site: MSA-2c 
#=GF ID   MSA-2c
#=GF AC   PF12238.10
#=GF DE   Merozoite surface antigen 2c
#=GF AU   Assefa S;0000-0003-2178-533X
#=GF AU   Gavin OL;
#=GF SE   PFAM-B_2755 (release 23.0)
#=GF GA   21.60 21.60;
#=GF TC   21.70 21.90;
#=GF NC   21.50 21.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   19120194
#=GF RT   msa-1 and msa-2c gene analysis and common epitopes assessment in
#=GF RT   Mexican Babesia bovis isolates.
#=GF RA   Borgonio V, Mosqueda J, Genis AD, Falcon A, Alvarez JA, Camacho
#=GF RA   M, Figueroa JV;
#=GF RL   Ann N Y Acad Sci. 2008;1149:145-148.
#=GF DR   INTERPRO; IPR021060;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins is found in eukaryotes. Proteins in this
#=GF CC   family are typically between 263 and 318 amino acids in length.
#=GF CC   There is a conserved SFT sequence motif. MSA-2 is a plasma
#=GF CC   membrane glycoprotein which can be found in Babesia bovis
#=GF CC   species.
#=GF SQ   15
#=GS A0A2H2IS21_CAEJA/427-586  AC A0A2H2IS21.1
#=GS A0A3L8PWY9_9GAMM/199-266  AC A0A3L8PWY9.1
#=GS Q3LUQ2_BABBO/64-249       AC Q3LUQ2.1
#=GS G2KQZ5_MICAA/134-262      AC G2KQZ5.1
#=GS A0A1B8D3Q9_9PEZI/189-300  AC A0A1B8D3Q9.1
#=GS A0A519X2R8_9SPHI/200-337  AC A0A519X2R8.1
#=GS Q95UH2_BABBO/70-255       AC Q95UH2.1
#=GS Q3LUQ1_BABBO/64-277       AC Q3LUQ1.1
#=GS Q9BHA2_BABBO/74-309       AC Q9BHA2.1
#=GS A0A0Q6VVV1_9ACTN/259-416  AC A0A0Q6VVV1.1
#=GS A0A2J6QBM3_9HELO/284-427  AC A0A2J6QBM3.1
#=GS A0A2B4RVS3_STYPI/108-281  AC A0A2B4RVS3.1
#=GS Q3LUQ2_BABBO/234-306      AC Q3LUQ2.1
#=GS A0A2J6TSK6_9HELO/284-428  AC A0A2J6TSK6.1
#=GS Q3LUQ3_BABBO/64-306       AC Q3LUQ3.1
A0A2H2IS21_CAEJA/427-586             ............................................eiaqfpln------------------------------NFSLFEINNRDEKTDDDKFNLLKERLAIMNYSR--NFEFIKE---QMEILQSGKN..K....VTDYFQKIVGFNNiTNITVASIRKLIEISQTVKSDIMavkSFVQLLNELS...............TLSRKE..REITDELTNKASIRt...............................nfRPSgPS.VRPS.VR.....RPSAS-SA----......---..-------------------------.....-------------vrpvrprtd....................
A0A3L8PWY9_9GAMM/199-266             ..................................................gv-----------------------------------------------------------SERIEHQHSMEQAITIRTNELIHTHN..E....LKQEITERIQAEK.LHKTLFEIASLCHDDLDDEHFYQ...KLS-------...............------..--------------..................................---.--.----.--.....------------......---..-------------------------.....-------------.............................
Q3LUQ2_BABBO/64-249                  ....................................................DMPSDCSRDALKALKDILVVLKEEIPFETSLFDNEVLRELEIQDQDQIFKSLLERVPLIKTMLTEFNAFLND---NPQRLLADKN.gE....VTKYYKKHISAKDaNVKDYKTMVKFCNDFLDSKSPFM...---RLYKHLN...............------..--EYDELVKKKPAQ..................................ESS.PApSSAQ.RP.....AETQQTQDSAAPs....tPAA.pSPPQRPAE-----TQQ---------.....-------------tqdst........................
G2KQZ5_MICAA/134-262                 lssdfwqgdegkfqktypvgptavfvddaefndgtmtwnaqvnlaiadesgs-------------------------------------------------------------------------------------..-....-------------.-----------------------...----------...............TAIGAVtvEVNLTELQRRMQAR..................................KDV.KT.ADAE.EP.....APEPVVEPVAQP......AAE.pTAEATPAPETPAATPAPENNAQ---.....-------------paestg.......................
A0A1B8D3Q9_9PEZI/189-300             ................edtdllrdydnlfrifynyppsldpiniadayiqck-------------------------------------------------------------------------------------..-....-------------.-----------------------...----------...............-SLLAL..ADMYDALVGARPRE..................................S-T.TT.SSNS.NP.....ASSSK-SPSTRP......PTS..ASATWPAPKSSSPKPSSTSSANGPS.....ASG----------tsatp........................
A0A519X2R8_9SPHI/200-337             ...............................................kskir---------------------------RSNKYAAMVMPNIGYDQNEEITDGVIHVTITLKTFLAKTDCWLGSSYKDSYMLNHEQRhfDvakiVTEQFNKQIA-KA.KLNTDNYEAVINMQYLDSYRDMN...KLQKDYDAQT...............-AHGLN..RTAQDTWNKR----..................................---.--.----.--.....------------......---..-------------------------.....-------------iddllagk.....................
Q95UH2_BABBO/70-255                  ....................................................GMEATSATKTHDALKAVKQLIKTDAPFNTSDFDTLDLEYLSGQSNEELLKLLIEAIYGMEIIIEKTNSFVGESAKHSDKLDTD--..-....LRQYYWDNIY---.----------------DDQSEYNk.dKLSNLYKAFI...............TDSGAL..RIASEELIKFETRKaqkd.........................dyrfiNPS.ST.SEAE.TP.....SPSSGENTAAQP......P--..KPAETPKP-----------------.....TGSSFTYGGLTVA.............................
Q3LUQ1_BABBO/64-277                  ....................................................DMPSDCSRDALKALKDILVVLKEEIPFETSLFDNEVLRELEIQDQDQIFKSLLERVPLIKTMLTEFNAFLND---NPQRLLADKN.gE....VTKYYKKHISAKDaNVKDYTFLVKFCNDYLDSESPFM...---KMYKAFN...............------..--TYEELLKKMPSK..................................TPS.PT.SSPQaTPgakpaAPNTSESAGGQPqq..etPEN..RPSQAPSPQSPPQTEQSTSNLNGPS.....KSASFTFGGLTVA.............................
Q9BHA2_BABBO/74-309                  ....................................................KMDDQKVKDTFKNLYKVNALIKNNPMIRPDLFNATIVSGFSTKNDEEKFNAIFDSIKGMYYRAQHMDKYLKSLRWNTDIVEEDRE..K....AVEYFKKHVYTGE.HVVDVNGMAGVCKEFLSPASDFY...KLVESFDAFAhakvhaqvgnfvkpgTDIAPP..KDVTDALEKELQEQ..................................KPA.RS.ESTE.VP.....APGDA-SGVQQP......PAS.gTSPQGPAPTTPSPSPESSGNLQGQQgttkpAGSSFTYGGLTVA.............................
A0A0Q6VVV1_9ACTN/259-416             .............................................sagtltr-----------------------------------------------------------------FDRVVSFLDAATKSLRTDEElgS....VTRLGKLAMQLRS.VGLDKIKFVTLPTEYYPSDSEFR..gKVFWKPEAQKi.............wDLINAD..KELPPSLIKGTSTNa................................ePPA.SS.SETT.SPt...sTPSSSDSESPSA......PGS.eTPSETPSE-TASETPSSS-------.....-------------pstpattedae..................
A0A2J6QBM3_9HELO/284-427             .............................................gvpnata------------------------------------------------------------------------------TVERD--..-....VTNAFKTFATRER.RVVENARMTKAKNDKEIKLNDLK...KFADSFKLHTp............vpSDLVPI..IAKDPAKQKEIQEK..................................ARR.NA.EESK.AH.....APEAAKPIAAVP......DAA..KPAQRPAPATHGTSPANLPNRQNPG.....RNSAFVQG-----tyns.........................
A0A2B4RVS3_STYPI/108-281             ................tiqrellekradilhvksgfdvavfyrakhgtgksf-------------------------------------------------------------------------------------..-....-------------.---YYYGTPGLGEEFLRSNSDFA..pTVKDMFEAFSvqygpp...ptkaspQDPQPP..SDCPSAEASDLEHQ..................................QPS.NC.PSSQ.VP.....ASATA-SPADSPqtnnypSSQvlAPAIASHPDSPPT------------.....-------------lqptncpssqgrvsliadlgkssvclggk
Q3LUQ2_BABBO/234-306                 ..................................................sp-------------------------------------------------------------------------------------..-....-------------.-----------------------...----------...............------..------------PQ..................................RPA.ET.QQTQdST.....APGTPAAPSPQG......PTA.eSPSQADHPTKPTQTPE--GNLQGQQgttkpAGSSFTYGGLTVA.............................
A0A2J6TSK6_9HELO/284-428             ............................................egvpnata------------------------------------------------------------------------------TVERD--..-....VTNAFKTFATRER.RVVENARMTKAKNDKEIKLNDLK...KFANNFKLHTp............vpSDLVPI..IAKDPAKQKEIQEK..................................ARR.NA.EESSkTH.....APEAAKPIAAVP......DAT..KPAQRPAPAPHGTSPANTSNRQNPG.....RNSAFVQG-----pyn..........................
Q3LUQ3_BABBO/64-306                  ....................................................DMPSDNSLDAINAFVEILDSFKEKVPFKTSLFDNSVFDNLKYQDTDEIFKSLLLRVPLIKKMLSEFNAFLND--NPPHMLTNGKE..K....MTEYYKKNISKEDgEVKDYKTMVKFCNDFLDSKSPFM...---RLYKHLN...............------..--EYDELVKKKPAQesspapsspqrpaetqqtqdsaapstpaapsppqRPA.ET.QQTQdST.....APGTPAAPSPQG......PTA.eSPSQADHPTKPTQTPE--GNLQGQQgttkpAGSSFTYGGLTVA.............................
#=GC seq_cons                        .......................................................................................................................th.t.......hl.ps.........lsphapp.hthpp..hhp.hthsthtp-h.sstsshh...ph.p.acths.........................t.stL.Kch.tp..................................psu.so.ppsp.ss.....APsss.ssuspP......sss..pPuptPtPtp.s.o.t........................................................
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