GenomeNet

Database: Pfam
Entry: Maelstrom
LinkDB: Maelstrom
Original site: Maelstrom 
#=GF ID   Maelstrom
#=GF AC   PF13017.7
#=GF DE   piRNA pathway germ-plasm component
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Zhang D
#=GF GA   20.20 20.20;
#=GF TC   20.20 20.50;
#=GF NC   19.90 20.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   19032786
#=GF RT   Functional insight into Maelstrom in the germline piRNA pathway:
#=GF RT   a unique domain homologous to the DnaQ-H 3'-5' exonuclease, its
#=GF RT   lineage-specific expansion/loss and evolutionarily active site
#=GF RT   switch.
#=GF RA   Zhang D, Xiong H, Shan J, Xia X, Trudeau VL;
#=GF RL   Biol Direct. 2008;3:48.
#=GF DR   INTERPRO; IPR024970;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Maelstrom is a germ-plasm component protein, that is shown to be
#=GF CC   functionally involved in the piRNA pathway. It is conserved
#=GF CC   throughout Eukaryota, though it appears to have been lost from
#=GF CC   all examined teleost fish species.  The domain architecture
#=GF CC   shows that it is coupled with several DNA- and RNA- related
#=GF CC   domains such as HMG box, SR-25-like and HDAC_interact domains. 
#=GF CC   Sequence analysis and fold recognition have found a distant
#=GF CC   similarity between Maelstrom domain and the DnaQ 3'-5'
#=GF CC   exonuclease family with the RNase H fold (Exonuc_X-T,
#=GF CC   Pfam:PF00929); notably, that the Maelstrom domains from basal
#=GF CC   eukaryotes contain the conserved 3'-5' exonuclease active site
#=GF CC   residues (Asp-Glu-Asp-His-Asp, DEDHD). However, the animal and
#=GF CC   some amoeba maelstrom contain another set of conserved residues
#=GF CC   (Glu-His-His-Cys-His-Cys, EHHCHC). This evolutionary link
#=GF CC   together with structural examinations leads to the hypothesis
#=GF CC   that Maelstrom domains may have a potential nuclease-transposase
#=GF CC   activity or RNA-binding ability that may be implicated in piRNA
#=GF CC   biogenesis. A protein function evolution mode, namely "active
#=GF CC   site switch", has been proposed [1], in which the amoeba
#=GF CC   Maelstrom domains are the possible evolutionary intermediates
#=GF CC   due to their harbouring of the specific characteristics of both
#=GF CC   3'-5' exonuclease and Maelstrom domains.
#=GF SQ   437
#=GS A0A452HJ56_9SAUR/126-328  AC A0A452HJ56.1
#=GS A0A1B0ACA5_GLOPL/47-202   AC A0A1B0ACA5.1
#=GS B4NGZ5_DROWI/1-202        AC B4NGZ5.1
#=GS A0A337ST33_FELCA/98-297   AC A0A337ST33.1
#=GS A0A0N4XI22_NIPBR/43-163   AC A0A0N4XI22.1
#=GS A0A0N4X0E8_HAEPC/49-116   AC A0A0N4X0E8.1
#=GS A0A1S3FL01_DIPOR/98-297   AC A0A1S3FL01.1
#=GS A0A1I8PQG2_STOCA/125-337  AC A0A1I8PQG2.1
#=GS A0A1D1W9D6_RAMVA/121-278  AC A0A1D1W9D6.1
#=GS K7IQB0_NASVI/114-304      AC K7IQB0.1
#=GS MAEL1_DROPS/125-346       AC B5DR03.1
#=GS A0A2U3YBV3_LEPWE/98-297   AC A0A2U3YBV3.1
#=GS B7PC60_IXOSC/37-83        AC B7PC60.1
#=GS A0A1A9ZXQ9_GLOPL/124-334  AC A0A1A9ZXQ9.1
#=GS A0A182FNR3_ANOAL/126-336  AC A0A182FNR3.1
#=GS V4AYE1_LOTGI/127-334      AC V4AYE1.1
#=GS A0A087ZMV4_APIME/127-336  AC A0A087ZMV4.1
#=GS H0ZTG5_TAEGU/124-324      AC H0ZTG5.1
#=GS A0A2U3WHY3_ODORO/129-314  AC A0A2U3WHY3.1
#=GS A0A2A2LCL2_9BILA/278-404  AC A0A2A2LCL2.1
#=GS H2ZD20_CIOSA/136-229      AC H2ZD20.1
#=GS A0A1S3A3R6_ERIEU/129-328  AC A0A1S3A3R6.1
#=GS T1KH43_TETUR/50-289       AC T1KH43.1
#=GS A0A182LH32_9DIPT/124-333  AC A0A182LH32.1
#=GS A0A368FK86_ANCCA/125-195  AC A0A368FK86.1
#=GS B4NGV0_DROWI/1-201        AC B4NGV0.2
#=GS A0A1S3FLM6_DIPOR/129-328  AC A0A1S3FLM6.1
#=GS MAEL_BOVIN/129-314        AC Q32KV2.1
#=GS X6RGB1_HUMAN/98-297       AC X6RGB1.1
#=GS E1C5I1_CHICK/73-276       AC E1C5I1.5
#=GS A0A0B2VU42_TOXCA/229-485  AC A0A0B2VU42.1
#=GS A0A226EXB5_FOLCA/322-401  AC A0A226EXB5.1
#=GS A0A226P902_COLVI/180-293  AC A0A226P902.1
#=GS MAEL2_DROAN/124-345       AC B3MZY6.1
#=GS A0A091XXG5_OPIHO/87-290   AC A0A091XXG5.1
#=GS A0A3Q7XFN6_URSAR/98-297   AC A0A3Q7XFN6.1
#=GS A0A182LT72_9DIPT/79-288   AC A0A182LT72.1
#=GS F7BVW2_MONDO/132-331      AC F7BVW2.1
#=GS A0A0R3QU16_9BILA/56-274   AC A0A0R3QU16.1
#=GS A0A2U4BCW1_TURTR/129-328  AC A0A2U4BCW1.1
#=GS A0A2K6QRC4_RHIRO/98-297   AC A0A2K6QRC4.1
#=GS MAEL_PIG/129-329          AC A4UTQ0.1
#=GS A0A443S9I7_9ACAR/178-335  AC A0A443S9I7.1
#=GS A0A182G7Y4_AEDAL/135-345  AC A0A182G7Y4.1
#=GS A0A0R3NW75_DROPS/32-139   AC A0A0R3NW75.1
#=GS A8XL15_CAEBR/178-417      AC A8XL15.1
#=GS A0A182V656_ANOME/124-333  AC A0A182V656.1
#=GS A0A1B0C3B9_9MUSC/124-334  AC A0A1B0C3B9.1
#=GS A0A482X5U8_LAOST/141-360  AC A0A482X5U8.1
#=GS A0A2J7QJL8_9NEOP/130-345  AC A0A2J7QJL8.1
#=GS A0A1I8PJ21_STOCA/126-337  AC A0A1I8PJ21.1
#=GS A0A3M0JLI5_HIRRU/123-315  AC A0A3M0JLI5.1
#=GS A0A016SPH6_9BILA/1-75     AC A0A016SPH6.1
#=GS A0A182MX82_9DIPT/86-296   AC A0A182MX82.1
#=GS A0A099ZBC0_TINGU/13-215   AC A0A099ZBC0.1
#=GS A0A2G5VVM0_9PELO/177-387  AC A0A2G5VVM0.1
#=GS E2BCV5_HARSA/135-346      AC E2BCV5.1
#=GS A0A182YJT8_ANOST/110-319  AC A0A182YJT8.1
#=GS A0A4Y0APQ8_ANOFN/112-321  AC A0A4Y0APQ8.1
#=GS U3IGF2_ANAPP/125-327      AC U3IGF2.2
#=GS A0A2H2HV77_CAEJA/543-795  AC A0A2H2HV77.1
#=GS A0A151X1R6_9HYME/134-346  AC A0A151X1R6.1
#=GS A0A0H5S0H9_BRUMA/176-385  AC A0A0H5S0H9.1
#=GS E3LLZ9_CAERE/249-474      AC E3LLZ9.1
#=GS A0A1S4ESF7_DIACI/83-262   AC A0A1S4ESF7.1
#=GS A0A2K6EKY3_PROCO/98-298   AC A0A2K6EKY3.1
#=GS A0A3L8SJY2_CHLGU/160-361  AC A0A3L8SJY2.1
#=GS A0A2A4JQA5_HELVI/127-290  AC A0A2A4JQA5.1
#=GS C4LSX8_ENTHI/32-228       AC C4LSX8.1
#=GS L8H4J4_ACACA/252-417      AC L8H4J4.1
#=GS A0A2U3WHY7_ODORO/98-297   AC A0A2U3WHY7.1
#=GS A0A3Q7TV40_VULVU/123-322  AC A0A3Q7TV40.1
#=GS A0A1U7SZT0_TARSY/130-330  AC A0A1U7SZT0.1
#=GS A0A3B0J8T9_DROGU/125-347  AC A0A3B0J8T9.1
#=GS A0A067RCN6_ZOONE/1-140    AC A0A067RCN6.1
#=GS D3TMT1_GLOMM/124-334      AC D3TMT1.1
#=GS A0A1B0FAD1_GLOMM/85-141   AC A0A1B0FAD1.1
#=GS Q17MK4_AEDAE/23-233       AC Q17MK4.1
#=GS A0A1U7RJ10_ALLSI/127-328  AC A0A1U7RJ10.1
#=GS A0A151INH4_9HYME/134-346  AC A0A151INH4.1
#=GS A0A0L7RAQ2_9HYME/88-296   AC A0A0L7RAQ2.1
#=GS A0A1A9X579_9MUSC/107-284  AC A0A1A9X579.1
#=GS L8YE98_TUPCH/54-137       AC L8YE98.1
#=GS A0A443SIV8_9ACAR/93-177   AC A0A443SIV8.1
#=GS H0V4J5_CAVPO/129-328      AC H0V4J5.2
#=GS A0A067QTJ5_ZOONE/133-352  AC A0A067QTJ5.1
#=GS A8XSR7_CAEBR/546-804      AC A8XSR7.1
#=GS A0A2K5E2J9_AOTNA/98-298   AC A0A2K5E2J9.1
#=GS A0A0R3RGA5_9BILA/179-270  AC A0A0R3RGA5.1
#=GS Q7PYM9_ANOGA/124-333      AC Q7PYM9.5
#=GS A0A182PRJ3_9DIPT/125-337  AC A0A182PRJ3.1
#=GS A0A2Y9F756_PHYMC/129-314  AC A0A2Y9F756.1
#=GS D2A077_TRICA/125-335      AC D2A077.1
#=GS A0A088ASY7_APIME/127-337  AC A0A088ASY7.1
#=GS A0A182XBA0_ANOQN/124-333  AC A0A182XBA0.1
#=GS A0A0S0WNT6_DROME/120-336  AC A0A0S0WNT6.1
#=GS A0A1V4J2W5_PATFA/83-286   AC A0A1V4J2W5.1
#=GS A0A212ETL5_DANPL/127-337  AC A0A212ETL5.1
#=GS A0A2K6TNQ8_SAIBB/129-328  AC A0A2K6TNQ8.1
#=GS A0A452G2I3_CAPHI/111-310  AC A0A452G2I3.1
#=GS A0A452G2G0_CAPHI/129-328  AC A0A452G2G0.1
#=GS A0A0D8X8F2_DICVI/97-251   AC A0A0D8X8F2.1
#=GS A0A0L8GI63_OCTBM/135-333  AC A0A0L8GI63.1
#=GS A0A182NCG6_9DIPT/123-332  AC A0A182NCG6.1
#=GS MAEL_CULQU/134-346        AC B0W2W6.1
#=GS K1Q207_CRAGI/115-321      AC K1Q207.1
#=GS U4U4D0_DENPD/336-548      AC U4U4D0.1
#=GS G0N5M3_CAEBE/558-817      AC G0N5M3.1
#=GS A0A3M7RTH3_BRAPC/142-349  AC A0A3M7RTH3.1
#=GS A0A210QDH1_MIZYE/127-333  AC A0A210QDH1.1
#=GS MAEL1_DROAN/124-345       AC B3MB79.1
#=GS H0WWQ3_OTOGA/129-330      AC H0WWQ3.1
#=GS A0A091DDF8_FUKDA/129-328  AC A0A091DDF8.1
#=GS A0A267DJT1_9PLAT/138-355  AC A0A267DJT1.1
#=GS A0A2G5UEJ1_9PELO/544-802  AC A0A2G5UEJ1.1
#=GS G3X1T1_SARHA/88-289       AC G3X1T1.1
#=GS A0A1S3IAP5_LINUN/128-334  AC A0A1S3IAP5.1
#=GS A0A182U671_9DIPT/124-333  AC A0A182U671.1
#=GS A0A2Y9E286_TRIMA/98-297   AC A0A2Y9E286.1
#=GS A0A182M9N2_9DIPT/99-305   AC A0A182M9N2.1
#=GS A0A2G8L7G9_STIJA/141-292  AC A0A2G8L7G9.1
#=GS A0A1W4WEJ8_AGRPL/124-338  AC A0A1W4WEJ8.1
#=GS A0A2K5MLR7_CERAT/98-297   AC A0A2K5MLR7.1
#=GS F7B842_MACMU/129-328      AC F7B842.1
#=GS J9M1U3_ACYPI/115-340      AC J9M1U3.1
#=GS A0A226EI49_FOLCA/301-468  AC A0A226EI49.1
#=GS A0A2K6TNV8_SAIBB/98-297   AC A0A2K6TNV8.1
#=GS A0A1J1IMJ9_9DIPT/122-333  AC A0A1J1IMJ9.1
#=GS A0A1D2N7K7_ORCCI/130-362  AC A0A1D2N7K7.1
#=GS A0A1A9UYQ3_GLOAU/1-150    AC A0A1A9UYQ3.1
#=GS A0A182VU07_9DIPT/70-279   AC A0A182VU07.1
#=GS A0A2K5E297_AOTNA/129-329  AC A0A2K5E297.1
#=GS E0VM85_PEDHC/125-338      AC E0VM85.1
#=GS W5PQL8_SHEEP/129-331      AC W5PQL8.1
#=GS A0A151MDK0_ALLMI/127-328  AC A0A151MDK0.1
#=GS A0A1J1IJZ9_9DIPT/147-370  AC A0A1J1IJZ9.1
#=GS A0A1I8MZI2_MUSDO/125-337  AC A0A1I8MZI2.1
#=GS A0A2K5IKJ8_COLAP/129-328  AC A0A2K5IKJ8.1
#=GS A0A2U3WHY0_ODORO/129-328  AC A0A2U3WHY0.1
#=GS A0A2J7QK21_9NEOP/129-346  AC A0A2J7QK21.1
#=GS G3RA07_GORGO/221-420      AC G3RA07.2
#=GS A0A2J7PV15_9NEOP/84-301   AC A0A2J7PV15.1
#=GS A0A1A9X8R7_GLOFF/124-334  AC A0A1A9X8R7.1
#=GS A0A340XFZ8_LIPVE/73-273   AC A0A340XFZ8.1
#=GS A0A158NPF9_ATTCE/23-235   AC A0A158NPF9.1
#=GS A0A195B3K9_9HYME/134-346  AC A0A195B3K9.1
#=GS MAEL_DROGR/120-334        AC B4J3A3.1
#=GS A0A267DPG2_9PLAT/146-373  AC A0A267DPG2.1
#=GS MAEL2_DROPE/125-344       AC B4GN43.2
#=GS T1H9A4_RHOPR/160-389      AC T1H9A4.1
#=GS J9LPC6_ACYPI/126-356      AC J9LPC6.1
#=GS A0A044SPH5_ONCVO/175-272  AC A0A044SPH5.1
#=GS G1KVA0_ANOCA/12-192       AC G1KVA0.1
#=GS A0A182IIY3_9DIPT/128-339  AC A0A182IIY3.1
#=GS A0A3P6SJS7_LITSI/180-243  AC A0A3P6SJS7.1
#=GS A0A1S3KH72_LINUN/128-334  AC A0A1S3KH72.1
#=GS A0A401S216_CHIPU/122-324  AC A0A401S216.1
#=GS A0A287DAJ3_ICTTR/129-328  AC A0A287DAJ3.1
#=GS A0A340X9A4_LIPVE/98-298   AC A0A340X9A4.1
#=GS A0A2I3LQJ3_PAPAN/98-297   AC A0A2I3LQJ3.1
#=GS A0A1I7TUI0_9PELO/21-195   AC A0A1I7TUI0.1
#=GS T1PAS7_MUSDO/126-338      AC T1PAS7.1
#=GS A0A3S3NRB3_9ACAR/35-247   AC A0A3S3NRB3.1
#=GS A0A087UHL8_9ARAC/132-335  AC A0A087UHL8.1
#=GS A0A3P6TEJ9_LITSI/159-367  AC A0A3P6TEJ9.1
#=GS A0A2G5VVQ8_9PELO/241-451  AC A0A2G5VVQ8.1
#=GS W4Z2P7_STRPU/146-242      AC W4Z2P7.1
#=GS B4KVI5_DROMO/91-245       AC B4KVI5.2
#=GS A0A2A2LCD4_9BILA/278-435  AC A0A2A2LCD4.1
#=GS A0A1D1VY12_RAMVA/185-401  AC A0A1D1VY12.1
#=GS C4M9Z0_ENTHI/31-249       AC C4M9Z0.1
#=GS A0A2K5RR82_CEBCA/129-328  AC A0A2K5RR82.1
#=GS E9GCR2_DAPPU/130-346      AC E9GCR2.1
#=GS E9HZ64_DAPPU/113-214      AC E9HZ64.1
#=GS A0A0M9A0Q0_9HYME/97-305   AC A0A0M9A0Q0.1
#=GS A0A2Y9JT65_ENHLU/129-329  AC A0A2Y9JT65.1
#=GS A0A0K0DIT6_ANGCA/79-286   AC A0A0K0DIT6.1
#=GS A0A2Y9M9K5_DELLE/98-297   AC A0A2Y9M9K5.1
#=GS A0A4Y0APT4_ANOFN/109-318  AC A0A4Y0APT4.1
#=GS A0A084VHB0_ANOSI/127-339  AC A0A084VHB0.1
#=GS H9JFX7_BOMMO/160-261      AC H9JFX7.1
#=GS A0A084VJ51_ANOSI/124-334  AC A0A084VJ51.1
#=GS J9LPF7_ACYPI/115-343      AC J9LPF7.2
#=GS A0A384CFX9_URSMA/73-272   AC A0A384CFX9.1
#=GS A0A195E4V1_9HYME/134-346  AC A0A195E4V1.1
#=GS A0A2A2KLW6_9BILA/250-488  AC A0A2A2KLW6.1
#=GS H3AJG6_LATCH/127-330      AC H3AJG6.1
#=GS A0A0N4W262_HAEPC/112-329  AC A0A0N4W262.2
#=GS A0A2K6DVG6_MACNE/129-328  AC A0A2K6DVG6.1
#=GS A0A0R3PGA7_ANGCS/43-154   AC A0A0R3PGA7.1
#=GS A0A0A6YWQ9_MOUSE/129-314  AC A0A0A6YWQ9.1
#=GS A0A1I7T2J1_9PELO/85-344   AC A0A1I7T2J1.1
#=GS A0A226CX36_FOLCA/301-468  AC A0A226CX36.1
#=GS G0MEQ2_CAEBE/272-491      AC G0MEQ2.1
#=GS A0A2B4SVS9_STYPI/298-388  AC A0A2B4SVS9.1
#=GS A0A151K344_9HYME/76-288   AC A0A151K344.1
#=GS A0A182KB73_9DIPT/124-333  AC A0A182KB73.1
#=GS A0A226EVN6_FOLCA/317-477  AC A0A226EVN6.1
#=GS F7DRD9_HORSE/129-328      AC F7DRD9.1
#=GS A0A484BR56_DRONA/101-248  AC A0A484BR56.1
#=GS A0A182DWT2_ONCOC/175-475  AC A0A182DWT2.1
#=GS A0A226EXB5_FOLCA/133-293  AC A0A226EXB5.1
#=GS A0A182Q4Y0_9DIPT/122-331  AC A0A182Q4Y0.1
#=GS A0A1D1VKC8_RAMVA/145-346  AC A0A1D1VKC8.1
#=GS A0A182GVW8_AEDAL/93-303   AC A0A182GVW8.1
#=GS E9G6J3_DAPPU/127-343      AC E9G6J3.1
#=GS A0A226EZY3_FOLCA/90-337   AC A0A226EZY3.1
#=GS A0A1D1VB94_RAMVA/82-253   AC A0A1D1VB94.1
#=GS A0A2A4J3Q4_HELVI/1-39     AC A0A2A4J3Q4.1
#=GS A0A1I7W1Z1_LOALO/822-909  AC A0A1I7W1Z1.1
#=GS G1RXJ4_NOMLE/129-328      AC G1RXJ4.1
#=GS E9JVC4_HUMAN/73-272       AC E9JVC4.1
#=GS A0A026WCS1_OOCBI/134-345  AC A0A026WCS1.1
#=GS A0A2J8LLY8_PANTR/129-328  AC A0A2J8LLY8.1
#=GS A0A286XZL5_CAVPO/129-314  AC A0A286XZL5.1
#=GS A0A3M6TNT0_9CNID/359-568  AC A0A3M6TNT0.1
#=GS A0A162CMH2_9CRUS/125-344  AC A0A162CMH2.1
#=GS MAEL_AEDAE/129-342        AC Q16YA8.1
#=GS A0A2I3T383_PANTR/98-297   AC A0A2I3T383.1
#=GS A0A226DK04_FOLCA/109-343  AC A0A226DK04.1
#=GS A0A2A3E308_APICC/127-336  AC A0A2A3E308.1
#=GS K7FSA6_PELSI/126-328      AC K7FSA6.1
#=GS A0A2P8Y5D4_BLAGE/131-347  AC A0A2P8Y5D4.1
#=GS A0A2T7P2L0_POMCA/130-341  AC A0A2T7P2L0.1
#=GS A0A2I2ZDT0_GORGO/98-297   AC A0A2I2ZDT0.1
#=GS A0A096NBP2_PAPAN/129-328  AC A0A096NBP2.2
#=GS A0A182H175_AEDAL/90-342   AC A0A182H175.1
#=GS A0A0N4TNB9_BRUPA/264-354  AC A0A0N4TNB9.1
#=GS A0A093IJ97_DRYPU/119-296  AC A0A093IJ97.1
#=GS A0A1B0GD09_GLOMM/124-334  AC A0A1B0GD09.1
#=GS G3TNX2_LOXAF/129-333      AC G3TNX2.1
#=GS A0A1U7SP49_TARSY/99-299   AC A0A1U7SP49.1
#=GS C3Z277_BRAFL/129-332      AC C3Z277.1
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#=GS MAEL_DROME/120-336        DR PDB; 4YBG A; 120-332;
#=GS A0A182W4I5_9DIPT/124-333  AC A0A182W4I5.1
#=GS A0A2Y9F8P8_PHYMC/98-297   AC A0A2Y9F8P8.1
#=GS A0A498SE67_ACAVI/164-383  AC A0A498SE67.1
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#=GS A0A2Y9F7L9_PHYMC/129-328  AC A0A2Y9F7L9.1
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#=GS A0A093SN94_9PASS/73-275   AC A0A093SN94.1
#=GS A0A1A9XZ79_GLOFF/156-366  AC A0A1A9XZ79.1
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#=GS A0A1D1W9B4_RAMVA/239-395  AC A0A1D1W9B4.1
#=GS A0A182R7Z0_ANOFN/122-331  AC A0A182R7Z0.2
#=GS B4LF74_DROVI/107-311      AC B4LF74.1
#=GS A0A2K5YX03_MANLE/98-297   AC A0A2K5YX03.1
#=GS A0A195EU64_9HYME/134-346  AC A0A195EU64.1
#=GS A0A182W4I4_9DIPT/121-330  AC A0A182W4I4.1
#=GS MAEL_HUMAN/129-328        AC Q96JY0.1
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B4NGZ5_DROWI/1-202                   .............................................m----------------------..-..--..S..I.....LS.....TL.IN.......P..G..EL.CLG....QA....F.....K.A....MHHSN.NTHQ...LP...LP.............P........N...A...E...G.E..............S...-MSKVYR.DIIK...YLKNC........................L---......NGKPLI.......................................................................................VF....T..P....T....Q......E......V....A....I......V..K..S....C..FDYMQtace......ldytD------Dsddedg.kkdplppILVYDIQYL.FFYLKKE.....TMGM.....M....GQ..PN....E.G.I..KH..D....V.TN..TI..FLRDFFE.F.EE.RI.....A..CQFHEEI.....DR...S.R.YCTRSQ.V.....VRW..V..YTFCDYM...CKDLG..ITMEPGKH.APS----fkp..........................................................
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A0A0N4XI22_NIPBR/43-163              ............................................nv----DGMCLMAEYAMNEFNLRD..G..VV..D..R.....FS.....TL.VG.......P..W..QI.PNE...iQR....N.....R.A....EFHSN.ETHR...IP...LS.............-........I...A...S...T.Q..............Y...DKRQLVM.EILG...RCEPEiarh...............qgirvG---......------.......................................................................................--....-..-....-....-......-......-....-....-......-..-..-....-..-----..............--------..............---------.-------.....----.....-....--..--....-.-.-..--..-....-.--..--..-------.-.--.--.....-..-------.....--...-.-.------.-.....---..-..-------...-----..--------.-------lyseekeeiddrfnrlyvgdrsfpcseeryvl.............................
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A0A0R3QSN4_9BILA/227-318             ............................................nv----DGICIPAEIAICEFNLKH..G..II..D..K.....YT.....SI.IG.......P..W..RL.NNE...iQR....R.....R.A....EFHAN.ETHQ...IH...LD.............-........-...-...-...-.-..............-...-------.----...-----........................----......------.......................................................................................--....-..-....-....-......-......-....-....-......-..-..-....-..-----..............--------..............---------.-------.....----.....-....--..--....-.-.-..--..-....-.--..--..-------.-.--.--.....-..-------.....--...-.-.------.-.....---..-..-------...-----..--------.-------mfggrtfkvptqnsclkeilgrceptiahyqgvfv..........................
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MAEL_DROSI/132-313                   ..............................................KALTTDVYVPAEFAACEYSLKE..G..IR..S..I.....YS.....TM.ID.......P..G..QI.IFG....QG....S.....D.A....LHNSS.TTHD...LP...LP.............P........N...A...L...G.E..............K...NMVKLYR.NILD...YLTKC........................QGEG......--KTPI.......................................................................................VF....T..P....A....E......N......I....G....M......V..K..S....C..FRYLE..............CEDDSRDGg...........gkIEVFDIQYL.LFILKKE.....VMSV.....A....GL..ND....E.K.I..NK..F....A.TD..AF..FKNDFFE.F.TA.GI.....A..CQI----.....--...-.-.------.-.....---..-..-------...-----..--------.-------ssintrdyhva..................................................
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A0A4D9EL49_9SAUR/126-328             ............................................ps--PCEQRFLPCEIGCVKYSLQD..G..IT..A..D.....FH.....RF.VD.......P..G..EV.PRG....FR....F.....H.C....QAASN.ATHK...IP...IS.............G........F...E...L...S.N..............A...GHPVVLR.ELYS...FVRPN........................R---......-SRWPP.......................................................................................VY....C..K....S....D......D......W....Y....R......V..N..W....C..LKWMA..............KEAGIENQ..............LELLSVENL.VVELYQR.....KL--.....-....--..-R....K.E.P..SK..T....W.VR..NL..LDVFMWD.Y.SS.NT.....R..CKWHEEN.....DI...-.L.FCALAS.C.....KKT..A..YCISNTL...ASVYG..VSLTT-AH.LPLQ---dy...........................................................
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G0MET8_CAEBE/182-423                 ............................................wk---NDGECMMAEIALNEFSLFS..G..II..E..K.....FH.....AI.VG.......P..W..QT.DNE...sQR....R.....R.A....KNFQL.VEEI...LG..rVE.............P........S..iA...C...H.Q..............G...VKVGLYS.DSCNektRIELNikn.................nfkdP--Gmi..cdKNDRRF.......................................................................................VL....V..L....Q....S......E......L....D....L......M..V..E....S..MKHLA..............KTVGFHYDgfpv.....hhnnfVIVEAFVEA.ISDIMNE.....KVDM.....E....TM..RW....F.S.L..LG..Q....K.ID..AE..DSVSPWE.T.GT.DF.....H..CSRHSE-.....PK...S.N.FCAAVT.V.....GRT..C..CIIYHVLggfFRRYH..LKKIPTAHhIPSTS--ts...........................................................
I3MPR1_ICTTR/129-314                 .............................................h---CEQRFLPCEIGCVKYSLQE..G..IM..A..D.....FH.....SF.IS.......P..G..--.---....--....-.....-.-....----D.SSHK...IP...IS.............N........F...E...L...G.H..............-...DQATVLQ.NLYR...FIHPN........................PG--......--NWPP.......................................................................................IY....C..K....S....D......D......R....A....R......V..N..W....C..LKRMA..............RALEFRQD..............LELLTVEDL.VVGIYQQ.....KF--.....-....--..-L....K.E.P..SK..T....W.VR..SL..LDVAMWD.Y.SS.NT.....R..CKWHEEN.....DI...-.L.FCALAV.C.....KRM..A..YCISNSL...ATLFG..IQLTG-AH.VPLQ---dy...........................................................
A0A2I3GEV4_NOMLE/98-297              .............................................h---CEQRFLPCEIGCVKYSLQE..G..IM..A..D.....FH.....SF.IN.......P..G..EI.PRG....FR....F.....H.C....QAASD.SSHK...IP...IS.............N........F...E...R...G.H..............-...NQATVLQ.NLYR...FIHPN........................PG--......--NWPP.......................................................................................IY....C..K....S....D......D......R....T....R......V..N..W....C..LKHMA..............KASEIRQD..............LQLLTVEDL.VVGIYQQ.....KF--.....-....--..-L....K.E.P..SK..T....W.IR..SL..LDVAMWD.Y.SS.NT.....R..CKWHEEN.....DI...-.L.FCALAV.C.....KKI..A..YCISNSL...ATLFG..IQLTE-AH.VPLQ---dy...........................................................
A0A182R9G6_ANOFN/122-330             ............................................rt---DEGAYIPAELGVIRFSLEC..G..VK..D..Q.....LH.....IH.IN.......C..E..KL.PLG....VA....L.....Q.A....KEHAT.NTHG...LP...LP.............P........N...A...L...G.V..............T...DYNTISS.NLLT...FLQVK........................E---......--EIPL.......................................................................................LF....T..D....A....K......E......V....P....I......V..K..N....M..LTTIL..............GNYTKSKP..............LRISSVADL.FFEMKQG.....AEMH.....M....MS..MK....V.F.P..SV..K....A.AQ..DI..IDEDPFS.Y.TE.NI.....S..CAYHESC.....AL...T.Q.ECALSK.C.....IRW..A..YTISKVC...CFEMN..IDLIPGKH.VP-----igwe.........................................................
A0A2P8Z8A9_BLAGE/132-343             ...........................................rqe----NGMYTPCEIALARFTLHK..G..ID..K..T.....FH.....TL.ID.......P..G..DI.PLG....YT....F.....E.A....STISK.ETHQ...IP...VP.............P........D...R...Y..gG.E..............R...DYYKIFT.SVKG...FVSEN........................K---......--DVRP.......................................................................................LY....T..H....D....T......R......I....D....A......V..R..N....V..LERLQ..............EDLPETVD..............FRVYPLTKL.FFELRNA.....SASL.....S....FD..GA....VgF.P..AF..S....L.AE..RE..LDRDVFS.F.EK.GI.....S..CDFHEKT.....DA...T.P.HCSLSC.V.....KRW..A..YLIMDYC...CKDLD..IKLVAGSH.CPVHAD-t............................................................
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A0A154PT33_DUFNO/89-303              ...........................................gin----QYDFCPAEFALAEFSFER..G..VE..N..V.....YH.....EV.VS.......-..A..KI.PLG....WK....R.....D.A....LETSR.ETHK...IP...IE.............-........H...P...D...G.Q..............S...DFAFMYT.QFVK...VLESN........................MTGD......--KYPP.......................................................................................LF....T..T....E....D......L......V....P....A......I..E..S....L..LRRMCqaa.......gnfiSGKSMND-..............FTIYSLEQL.FTALLNA.....ATKD.....T....TK..N-....C.S.I..PF..V....V.AK..HE..FGKDTFC.S.AT.GL.....E..CDFHRIL.....DS...S.Q.HCSMSI.V.....KRW..G..FTICDHC...CCYLD..IPRIEGVH.YPLS---rp...........................................................
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A0A2K6M1W9_RHIBE/98-297              .............................................h---CEQRFLPCEIGCVKYSLQE..G..IM..A..D.....FH.....SF.IN.......P..G..EI.PRG....FR....F.....H.C....QAASD.SSHK...IP...IS.............N........F...E...R...G.H..............-...NQATVLQ.NLYR...FIHPN........................PG--......--NWPP.......................................................................................IY....C..K....S....D......D......R....T....R......V..N..W....C..LKHMA..............KASEIRQD..............LQLLTVEDL.VVGIYQQ.....KF--.....-....--..-L....K.E.P..SK..T....W.IR..SL..LDVAMWD.Y.SS.NT.....R..CKWHEEN.....DT...-.L.FCALAV.C.....KKI..A..YCISNSL...ATLFG..IQLTE-AH.VPLQ---dy...........................................................
A0A1L8HC69_XENLA/144-347             ............................................pt--LCDQRYVPCEIACVRYSLRE..G..IL..G..S.....FH.....DF.ID.......P..G..EL.PHG....FR....Y.....H.C....QSGSA.STHH...IP...IS.............G........F...E...L...A.N..............S...DYHNMFR.KFCS...FVCPT........................PS--......--IRVP.......................................................................................VY....T..K....A....N......D......I....Y....R......V..D..W....C..LQWLA..............NKAGMENH..............FQVHEVEGL.IIKFYQD.....KL--.....-....--..-K....E.E.P..SR..P....S.VS..RL..LDTVQWD.Y.SS.NT.....R..CKWHEDN.....DM...-.W.CCVLAS.C.....KKI..A..YCISKAL...ASVYG..VTLTP-AH.LPN----lels.........................................................
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A0A3S3PK25_9ACAR/93-308              ..........................................kvkn----HFIYLPLEIGLIKYSIEK..Q..VI..D..E.....FH.....AF.ID.......C..G..PI.PNG....CA....S.....E.A....LQLC-.EKHG...IP...VD.............N........R...R...E...M.Qkv..........cpQ...PATRVVE.NLLT...FFSKD........................SKSI.....tNDKKFV.......................................................................................CF....T..F....G....D......K......I....T....S......T..Y..G....G..YEWLDi............eMNIASEKE..............LRLPEISSLsIYDLAYE.....II-R.....Y....IR..GK....E.F.A..DK..P....M.IE..HE..FNTSIYD.F.ET.GI.....N..CKFHETI.....DN...-.F.NCALGN.S.....RRM..A..CVFSALM...FQCF-..--------.-------gtapimkplnr..................................................
A0A016SPE8_9BILA/1-212               ..............................................----------------------..-..--..-..-.....--.....-M.VG.......P..W..QI.SND...iQR....S.....R.A....EFHSN.ETHR...IP...LN.............-........I...A...S...T.Q..............L...DKRQLVM.EILG...RCEPEiarrqg............irvglyT---......-----Eetediddrfnrlyvg.........................................................drnpyllandegrrwII....C..L....K....Q......E......Y....R....N......M..L..A....A..TQHLA..............RSLGLDYTgfpt.....addryVLADAFLAA.LADCLQG.....EAVA.....E....AG..SW....L.A.A..LG..K....H.LP..EE..FA-TPWE.R.SG.EL.....F..CSRHRA-.....DR...N.S.CCATVT.A.....SRA..T..FIILYA-...-----..--------.-------veqllk.......................................................
R0JYP5_ANAPL/41-243                  ...........................................psh---CDQRFLPCEIGCVKYSLQN..G..IM..A..D.....FH.....HF.ID.......P..E..VP.PRG....FR....Y.....H.C....QTASD.ATHK...IP...IS.............G........F...H...L...S.R..............T...CYPVVLR.ELLE...FAQPD........................GG--......--GWPR.......................................................................................FF....C..R....A....D......D......R....F....R......V..T..W....C..LERMA..............SVAGIESH..............LELLTVEDL.VIKLYQK.....KY--.....-....--..-Q....K.E.P..SK..T....W.VC..RE..LDAVLWD.F.SS.NT.....R..CKWHEEN.....GI...-.L.FCALAS.C.....KKI..A..YCISKSL...AGVYG..VPLTA-TH.LPLQ---dc...........................................................
A0A1B0B350_9MUSC/156-366             ..........................................ktsd----GSVYIPAELSICEYSLKQ..G..VI..R..T.....FH.....TF.IN.......P..G..VK.MYG....HQ....L.....E.A....QRHSD.ATHG...LP...FP.............P........N...A...M...G.D..............K...NLGNIYN.AVLK...FLSSN........................D---......--DFPP.......................................................................................LY....T..S....P....G......C......I....H....I......V..D..S....V..LNFLK..............SDIGANNA.............tLSVYSIQYL.FYVMKEA.....TCDQ.....G....-E..LE....K.P.K..TF..H....I.TD..AY..FERDYFE.Y.QS.GI.....A..CQFHEDK.....DR...G.K.YCTQSL.V.....IRW..G..YMFSEYM...CQDIA..ISLIPGRH.VPRSTN-l............................................................
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J9JS67_ACYPI/74-298                  ............................................en---IEQYYFPAEIAALEFSLID..G..IY..R..T.....YH.....QV.IG.......I..S..KIyPRG....FA....G.....S.M....KQFSD.RFHR...I-...-V.............C........F...D...E...H.P..............D...DYQQILL.EFST...FLKDGiin..................hedLK-E.....gTLDLPY.......................................................................................LF....T..I....E....S......E......VgtnmM....H......T..K..N....S..LERLY..............STVYPRVDder.......cksiFKIGNVEGL.FLEIKKK.....I-NL.....N....MN..IQ....N.L.I..SE..N....S.VL..DI..LESDMYG.Y.--.GL.....G..CQYHECR.....EI...S.Y.KCSKAR.V.....IQW..M..SNICKHI...CENTG..ITLNPGRH.-------tave.........................................................
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A0A1D5R4L1_MACMU/115-314             .............................................h---CEQRFLPCEIGCVKYSLQE..G..IM..A..D.....FH.....SF.IN.......P..G..EI.PRG....FR....F.....H.C....QAASD.SSHK...IP...IS.............N........F...E...R...G.H..............-...NQATVLQ.NLYR...FIHPN........................PG--......--NWPP.......................................................................................IY....C..K....S....D......D......R....T....R......V..N..W....C..LKHMA..............KASEIRQD..............LQLLTVEDL.VVGIYQQ.....KF--.....-....--..-L....K.E.P..SK..T....W.IR..SL..LDVAMWD.Y.SS.NT.....R..CKWHEEN.....DI...-.L.FCALAV.C.....KKI..A..YCISNSL...ATLFG..IQLTE-AH.VPLQ---dy...........................................................
A0A2Y9F7L9_PHYMC/129-328             .............................................h---CEQRFLPCEIGCVKYSLQE..G..IM..A..D.....FH.....SF.IN.......P..G..EI.PRG....FR....F.....H.C....QAASD.SSHK...IP...IS.............N........F...E...S...G.H..............-...NQAMVLQ.NLYR...FIHPN........................PG--......--NWPP.......................................................................................VY....C..K....S....D......D......I....A....R......V..N..W....C..LKHME..............KSSEIRQD..............LELLTVEDL.VIGIFQQ.....KF--.....-....--..-L....K.E.P..SK..T....W.VR..SF..LDVAMWD.Y.SS.NT.....R..CKWHEEN.....DI...-.L.LCALAV.C.....KKI..A..YCISNSL...ATLFG..IQLTE-AH.VPLQ---dy...........................................................
A0A0R3P2D1_DROPS/125-344             ..............................................KALTGDLYVPAEFSACRYSLKG..G..IS..S..N.....YS.....TM.IN.......P..G..HI.IYG....QS....R.....D.A....QDHSK.TTHK...LP...LP.............P........Q...A...F...G.E..............T...NMGKLYI.DIFN...WLSVR........................NEEK.....lDQDPVI.......................................................................................VY....T..T....P....E......L......M....P....V......V..K..S....C..FRYLA..............SEAEIDEDe...........rkIMVFDIYHL.FYTLKKS.....VLDV.....A....GV..TN....D.R.I..NF..H....V.TN..NF..FVKDFFE.Y.TE.GI.....A..CDYHEKI.....DR...S.K.YCTNSM.V.....KRW..G..FTFSDYM...CADLA..IPLQPGKH.IPLKVK-p............................................................
A0A093SN94_9PASS/73-275              ...........................................sqc----ELRFLPCEIGCVRYSLQD..G..IT..A..D.....FH.....HF.IE.......P..E..AP.PRG....FR....Y.....H.C....QAAGA.ETHK...IP...IS.............G........F...H...L...P.R..............T...CYAVVLQ.ELLE...FAQPA........................RG--......--VQPR.......................................................................................FF....C..R....S....N......D......R....F....Q......I..N..W....C..LGRMA..............TVAGIESS..............LQLFAVEDL.IVELYLK.....KY--.....-....--..-L....K.E.P..SK..T....W.VS..RK..LDVCLWD.F.SS.NT.....R..CKWHEEN.....DI...-.I.CCALAS.C.....KKI..A..YCISRSL...ANVYG..VPLTA-AH.LPL----gvsh.........................................................
A0A1A9XZ79_GLOFF/156-366             ..........................................ktsd----GSVYIPAELSICEYSLKQ..G..VI..R..T.....FH.....TF.IN.......P..G..VK.MYG....HQ....L.....E.A....QRHSD.ATHG...LP...FP.............P........N...A...M...G.D..............K...NLGNIYN.AVLK...FLSSN........................D---......--DFPP.......................................................................................LY....T..S....P....G......C......I....H....I......V..D..S....V..LNFLK..............SDIGANNA.............tLSVYSIQYL.FYVMKEA.....TCDQ.....G....-E..LE....K.P.K..TF..H....I.TD..AY..FERDYFE.Y.QS.GI.....A..CQFHEDK.....DR...G.K.YCTQSL.V.....IRW..G..YMFSEYM...CQDIA..ISLIPGRH.VPRSTN-l............................................................
A0A4X3P6Z1_PRIPA/179-422             ............................................gr---NEKECLLAEIAIDEFTLQE..G..VL..D..R.....MT.....TI.VS.......D..W..RV.DNP...iLK....S.....R.A....IFHAN.ETHE...IP...LD.............-........H...Q...H...H.D..............I...HKVQLIA.EILG...RIEPT........................IAKQ......-QSVSVglyrppkgnlcenglpaid.................................................rlnvddaddqfiscdgrrpIL....V..L....R....H......E......Y....Y....A......V..T..E....S..LLSFK..............KRMRLDYHgf.........pveESRFILAEA.FIEAVAA.....ELNG.....D....PM..DN....F.D.Q..VL..SelgkP.ME..AD..F-ATQWE.K.KD.EL.....F..CKFHADR.....-K...N.A.CCAAVT.A.....ARA..I..FIMI---...-----..--------.-------fsleklir.....................................................
A0A1D1W9B4_RAMVA/239-395             ...........................................lnr---------PLELAVTTFNLKE..G.rGI..G..F.....VH.....AF.VS.......P..G..NL.PSL....TH....A.....D.A....DECRL.ERHG...IP...YA.............K........N...L...A...P.DddtvqefyrtckvdE...DYLNMYK.RILN...FLGVLd......................iADAH......KFRLPP.......................................................................................VC....C..P....L....S......E......L....E....V......N..S..E....C..VRWLH..............AKAEEDI-..............---------.-------.....----.....-....--..--....-.-.-..--..-....-.--..--..-------.-.--.--.....-..-------.....--...-.-.------.-.....---..-..-------...-----..--------.-------kkqnltlelprlqfasleafsqmavfhkf................................
A0A182R7Z0_ANOFN/122-331             ............................................rt---IKGTYIPAELGVVKYSLKC..G..VM..D..R.....MH.....LY.IN.......P..G..EI.PLG....AA....L.....S.T....QQHTA.ETHK...LP...LP.............P........N...A...W...G.S..............T...DMNEVAV.KLIS...FLAAD........................D---......--EIPP.......................................................................................LF....T..D....E....T......T......L....P....I......T..E..S....M..LQELL..............SGRIEGKT..............LYVCPLSEL.FFCLKQA.....TERH.....V....ME..TP....T.F.P..SA..R....M.AQ..HI..LMMDCYG.F.TV.GI.....S..CDYHETE.....RN...P.I.NCALSQ.A.....TRW..A..YTISKHC...CLHMG..IECVQGKH.IPCD---rsa..........................................................
B4LF74_DROVI/107-311                 ............................................ny--FTKDACTPAELAVVQFTLKH..G..MR..N..I.....YH.....TL.IN.......P..D..--.--G....SQ....Y.....A.T....QEHVR.ATHQ...Y-...--.............P........N...A...L...G.N..............D...DLEGILA.DLLE...FVRLE........................CGPE......-AELSP.......................................................................................MF....T..L....E....S......Q......I....S....V......V..N..N....A..LEFLN..............GGVASQ--..............LKVHPIEYL.FYVLKKA.....TC-A.....A....GI..LP....P.P.A..SF..H....I.TN..AQ..FNLDPHE.F.LS.DI.....G..CEFHKQR.....DL...T.A.HCAKSY.V.....TRW..A..FAFADYM...CSDLA..IKMLPNRH.MPNRLD-t............................................................
A0A2K5YX03_MANLE/98-297              .............................................h---CEQRFLPCEIGCVKYSLQE..G..IM..A..D.....FH.....SF.IN.......P..G..EI.PRG....FR....F.....H.C....QAASD.SSHK...IP...IS.............N........F...E...R...G.H..............-...NQATVLQ.NLYR...FIHPN........................PG--......--NWPP.......................................................................................IY....C..K....S....D......D......R....T....R......V..N..W....C..LKHMA..............KASEIRQD..............LQLLTVEDL.VVGIYQQ.....KF--.....-....--..-L....K.E.P..SK..T....W.IR..SL..LDVAMWD.Y.SS.NT.....R..CKWHEEN.....DT...-.L.FCALAV.C.....KKI..A..YCISNSL...ATLFG..IQLTE-AH.VPLQ---dy...........................................................
A0A195EU64_9HYME/134-346             ............................................vn---NTLEYFPAEYTFGVFSLEN..G..IE..D..V.....HH.....TI.VS.......-..A..KI.PLG....YR....R.....E.A....LEISQ.NSHK...IP...VE.............-........Y...E...G...G.E..............I...DFAVMYD.KLAN...FLESR........................KIVD......--QYPY.......................................................................................LY....T..R....K....A......F......T....R....E......A..Q..S....L..IARLC..............GAAQQDKE.............qFKIYELESL.FVHLANE.....LFKK.....R....KD..RD....M.D.L..IP..V....Y.AH..KI..FENYTYR.F.DK.GF.....E..CHFHKYV....dGG...P.E.YCSKSV.L.....QQW..A..WTLCDEF...CAPLN..VEMQSGIH.QPDR---fdr..........................................................
A0A182W4I4_9DIPT/121-330             ............................................ct---FEGIYLPAELGVVKYNLEC..G..VT..D..R.....MH.....MH.IH.......L..D..EI.PLG....AA....L.....S.V....QTHTK.ATHQ...LP...LP.............P........N...A...L...G.K..............A...FGEEVAQ.CLLN...FLGAT........................D---......--EIPL.......................................................................................LF....T..N....D....Q......T......L....P....I......V..E..V....M..LRQLL..............SDRITDEM..............LYVCPLSEL.FCKLKQA.....AERQ.....F....LG..ES....Y.F.P..SA..L....T.AQ..YI..LQMDCYD.Y.VM.GI.....S..CDFHEKE.....FN...F.M.HCALSQ.A.....TRW..T..YIISKFC...CPNMG..IECIPGKH.IPLPTN-n............................................................
MAEL_HUMAN/129-328                   .............................................h---CEQRFLPCEIGCVKYSLQE..G..IM..A..D.....FH.....SF.IN.......P..G..EI.PRG....FR....F.....H.C....QAASD.SSHK...IP...IS.............N........F...E...R...G.H..............-...NQATVLQ.NLYR...FIHPN........................PG--......--NWPP.......................................................................................IY....C..K....S....D......D......R....T....R......V..N..W....C..LKHMA..............KASEIRQD..............LQLLTVEDL.VVGIYQQ.....KF--.....-....--..-L....K.E.P..SK..T....W.IR..SL..LDVAMWD.Y.SS.NT.....R..CKWHEEN.....DI...-.L.FCALAV.C.....KKI..A..YCISNSL...ATLFG..IQLTE-AH.VPLQ---dy...........................................................
#=GC SS_cons                         ..............................................E-SSSS-EEEEEEEEEEEETTT..E..EE..E..E.....EE.....EE.B-.......-..-..--.---....--....-.....-.H....HHHHH.HTT-...--...-T.............T........S...-...-...S.B..............-...-HHHHHH.HHHH...HHHHH........................H-SS......--S-EE.......................................................................................EE....E..-....G....G......G......H....H....H......H..H..H....H..HHHH-..............---HHHH--...........--EEEEEHHHH.HHHHHHH.....HHHH.....T....T-..--....T.T.-..-H..H....H.HH..HH..HHH-TTT.T.-T.T-.....S..-HHHHHH.....T-...G.G.G-HHHH.H.....HHH..H..HHHHHHH...GGGTT..----BTTT.B--XXX-X............................................................
#=GC seq_cons                        .............................................p....pttalPsEluhscaSLpc..G..Ih..s..p.....aH.....ph.Is.......P..G..pl.PhG....hp....h.....c.s....pttSc.poHp...IP...ls.............s........h...t...h...u.p..............t...shsplhp.plhp...Flpss.........................t..........phP........................................................................................la....s..p....s....c......c......h....t....h......V..p.......s..Lctht..............ptsthppp..............lplhslpcL.hhtlhpp.....th......................p...s..sh..p....h.sp..ph..lshsha-.a.ss.sh.....p..CcaHEct.....-h.....h.aCuhuh.s.....p+h..u..Yslss.h...sp.hs..lphh..tH.hP.p...s............................................................
//
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