GenomeNet

Database: Pfam
Entry: Malectin
LinkDB: Malectin
Original site: Malectin 
#=GF ID   Malectin
#=GF AC   PF11721.8
#=GF DE   Malectin domain
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Pfam-B_783 (release 23.0) pdb_2jwp
#=GF GA   23.00 23.00;
#=GF TC   23.00 23.00;
#=GF NC   22.90 22.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   18524852
#=GF RT   Malectin: a novel carbohydrate-binding protein of the
#=GF RT   endoplasmic reticulum and a candidate player in the early steps
#=GF RT   of protein N-glycosylation. 
#=GF RA   Schallus T, Jaeckh C, Feher K, Palma AS, Liu Y, Simpson JC,
#=GF RA   Mackeen M, Stier G, Gibson TJ, Feizi T, Pieler T, Muhle-Goll C; 
#=GF RL   Mol Biol Cell. 2008;19:3404-3414.
#=GF DR   INTERPRO; IPR021720;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Malectin is a membrane-anchored protein of the endoplasmic
#=GF CC   reticulum that recognises and binds Glc2-N-glycan. It carries a
#=GF CC   signal peptide from residues 1-26, a C-terminal transmembrane
#=GF CC   helix from residues 255-274, and a highly conserved central part
#=GF CC   of approximately 190 residues followed by an acidic,
#=GF CC   glutamate-rich region. Carbohydrate-binding is mediated by the
#=GF CC   four aromatic residues, Y67, Y89, Y116, and F117 and the
#=GF CC   aspartate at D186.  NMR-based ligand-screening studies has shown
#=GF CC   binding of the protein to maltose and related oligosaccharides,
#=GF CC   on the basis of which the protein has been designated
#=GF CC   "malectin", and its endogenous ligand is found to be
#=GF CC   Glc2-high-mannose N-glycan [1].
#=GF SQ   4114
#=GS A0A1W9SJ09_9BACT/1-109      AC A0A1W9SJ09.1
#=GS A0A1S4E4A7_CUCME/339-529    AC A0A1S4E4A7.1
#=GS A0A1G9LJF2_9BACT/6133-6293  AC A0A1G9LJF2.1
#=GS A0A0D2ZQS1_BRAOL/112-257    AC A0A0D2ZQS1.1
#=GS V4T6S8_9ROSI/2-179          AC V4T6S8.1
#=GS A0A2H3Y256_PHODC/419-601    AC A0A2H3Y256.1
#=GS A0A061FG54_THECC/409-589    AC A0A061FG54.1
#=GS A0A0E0AS28_9ORYZ/249-436    AC A0A0E0AS28.1
#=GS B9I1G1_POPTR/397-580        AC B9I1G1.1
#=GS A0A212UH14_9BACT/1047-1194  AC A0A212UH14.1
#=GS A0A287J3Z3_HORVV/424-611    AC A0A287J3Z3.1
#=GS A0A1S3VXE7_VIGRR/378-567    AC A0A1S3VXE7.1
#=GS A0A0E0G3Z7_ORYNI/316-499    AC A0A0E0G3Z7.1
#=GS A0A1D6A2E2_WHEAT/31-184     AC A0A1D6A2E2.1
#=GS A0A287MBY9_HORVV/2-139      AC A0A287MBY9.1
#=GS Q7XTP6_ORYSJ/425-612        AC Q7XTP6.2
#=GS V4QVV3_9CAUL/733-906        AC V4QVV3.1
#=GS A0A0E0JXR3_ORYPU/261-444    AC A0A0E0JXR3.1
#=GS A0A2A2RVW3_9BACT/1389-1477  AC A0A2A2RVW3.1
#=GS A0A0E0P6X6_ORYRU/326-513    AC A0A0E0P6X6.1
#=GS B9IH59_POPTR/10-191         AC B9IH59.1
#=GS A0A2G1VZL9_9PLAN/8-153      AC A0A2G1VZL9.1
#=GS B1ZXF5_OPITP/2016-2164      AC B1ZXF5.1
#=GS A0A218W1N7_PUNGR/406-467    AC A0A218W1N7.1
#=GS A0A2K1ZV54_POPTR/64-245     AC A0A2K1ZV54.1
#=GS A0A022QFS6_ERYGU/433-618    AC A0A022QFS6.1
#=GS A0A1F9X995_9BACT/21-174     AC A0A1F9X995.1
#=GS S7TFM9_DESML/905-1046       AC S7TFM9.1
#=GS A0A2H3WYC1_PHODC/417-599    AC A0A2H3WYC1.1
#=GS A0A0E0AS41_9ORYZ/1271-1450  AC A0A0E0AS41.1
#=GS C1F2W7_ACIC5/351-504        AC C1F2W7.1
#=GS A0A0B0MYM6_GOSAR/78-216     AC A0A0B0MYM6.1
#=GS A0A0D3LLU1_9BACT/480-623    AC A0A0D3LLU1.1
#=GS A0A0N4U1H9_DRAME/69-217     AC A0A0N4U1H9.1
#=GS A0A0J1G7Y2_9BURK/746-902    AC A0A0J1G7Y2.1
#=GS G8NWX1_GRAMM/203-354        AC G8NWX1.1
#=GS A0A0E0IHI4_ORYNI/403-588    AC A0A0E0IHI4.1
#=GS A0A0S8KL82_9CHLR/606-760    AC A0A0S8KL82.1
#=GS A0A0S8JNH8_9BACT/360-443    AC A0A0S8JNH8.1
#=GS A0A0D3LKG3_9BACT/1397-1544  AC A0A0D3LKG3.1
#=GS A0A1N7QIQ3_9BACT/714-889    AC A0A1N7QIQ3.1
#=GS J3MK03_ORYBR/2-98           AC J3MK03.1
#=GS A0A059BMZ8_EUCGR/323-510    AC A0A059BMZ8.1
#=GS A0A067KFH5_JATCU/441-609    AC A0A067KFH5.1
#=GS A0A1H4E3K2_9BACT/704-879    AC A0A1H4E3K2.1
#=GS A0A1H9K3P8_9EURY/463-601    AC A0A1H9K3P8.1
#=GS A0A1I6H391_9FLAO/378-545    AC A0A1I6H391.1
#=GS A0A1S4E509_CUCME/380-567    AC A0A1S4E509.1
#=GS F6H1V3_VITVI/1027-1209      AC F6H1V3.1
#=GS A0A1Y5KEQ0_9BACL/1113-1270  AC A0A1Y5KEQ0.1
#=GS A0A085EJH9_9FLAO/86-256     AC A0A085EJH9.1
#=GS M4CUL4_BRARP/418-604        AC M4CUL4.1
#=GS A0A0D2PY97_GOSRA/233-419    AC A0A0D2PY97.1
#=GS A0A0K9NZN2_ZOSMR/204-374    AC A0A0K9NZN2.1
#=GS A0A0D3APL2_BRAOL/1425-1611  AC A0A0D3APL2.1
#=GS A0A1B0D2G8_PHLPP/22-185     AC A0A1B0D2G8.1
#=GS M1BBW8_SOLTU/75-220         AC M1BBW8.1
#=GS A0A093EUN0_TYTAL/3-130      AC A0A093EUN0.1
#=GS A0A0E0DIE1_9ORYZ/2042-2222  AC A0A0E0DIE1.1
#=GS A0A194YNS5_SORBI/313-496    AC A0A194YNS5.1
#=GS A0A0E0HBI4_ORYNI/281-441    AC A0A0E0HBI4.1
#=GS A0A0E0KV84_ORYPU/2284-2465  AC A0A0E0KV84.1
#=GS A0A1U8Q113_NELNU/402-538    AC A0A1U8Q113.1
#=GS A0A069CZS4_9BACE/1009-1178  AC A0A069CZS4.1
#=GS A9VD51_MONBE/587-682        AC A9VD51.1
#=GS A0A2G2XEA5_CAPBA/426-606    AC A0A2G2XEA5.1
#=GS A0A1G8K4K7_9ACTN/1007-1162  AC A0A1G8K4K7.1
#=GS E8WUH3_GEOS8/288-430        AC E8WUH3.1
#=GS A0A1B1PU45_9RHOB/1182-1348  AC A0A1B1PU45.1
#=GS A0A1H6SY75_9BACT/3891-4040  AC A0A1H6SY75.1
#=GS M0CVX6_9EURY/1242-1402      AC M0CVX6.1
#=GS A0A1J7I5T6_LUPAN/7-159      AC A0A1J7I5T6.1
#=GS A0A2G9GH80_9LAMI/512-575    AC A0A2G9GH80.1
#=GS A0A0D2S273_GOSRA/384-570    AC A0A0D2S273.1
#=GS C5AQ83_METEA/1106-1251      AC C5AQ83.1
#=GS A0A0D9ZWD0_9ORYZ/502-692    AC A0A0D9ZWD0.1
#=GS A0A2G3A808_CAPAN/15-138     AC A0A2G3A808.1
#=GS A0A0D9VE36_9ORYZ/201-384    AC A0A0D9VE36.1
#=GS A0A2K2AQP9_POPTR/427-610    AC A0A2K2AQP9.1
#=GS M4FAL0_BRARP/388-573        AC M4FAL0.1
#=GS I1I1V6_BRADI/5-153          AC I1I1V6.1
#=GS A0A1F8S2G8_9CHLR/1757-1909  AC A0A1F8S2G8.1
#=GS Q7UIV5_RHOBA/7-153          AC Q7UIV5.1
#=GS A0A0C1FWB3_9SPHI/714-886    AC A0A0C1FWB3.1
#=GS A0A1U8PZZ5_NELNU/238-428    AC A0A1U8PZZ5.1
#=GS A0A1G0XBS2_9BACT/353-497    AC A0A1G0XBS2.1
#=GS C6XSG2_PEDHD/707-859        AC C6XSG2.1
#=GS A0A1U7ZZB7_NELNU/86-239     AC A0A1U7ZZB7.1
#=GS A0A1G8X6D5_9BACT/879-1030   AC A0A1G8X6D5.1
#=GS A0A0E0KV84_ORYPU/1346-1533  AC A0A0E0KV84.1
#=GS A0A1I0QXT8_9BACT/1532-1692  AC A0A1I0QXT8.1
#=GS A0A0E0AS41_9ORYZ/358-545    AC A0A0E0AS41.1
#=GS A0A0D3G0C7_9ORYZ/296-394    AC A0A0D3G0C7.1
#=GS A0A0D3D8L1_BRAOL/421-599    AC A0A0D3D8L1.1
#=GS A0A287J3R7_HORVV/354-541    AC A0A287J3R7.1
#=GS A0A287Q2U2_HORVV/176-321    AC A0A287Q2U2.1
#=GS M4EEU4_BRARP/306-489        AC M4EEU4.1
#=GS W5J957_ANODA/27-189         AC W5J957.1
#=GS H5UPT4_9MICO/41-179         AC H5UPT4.1
#=GS A0A251PIE9_PRUPE/357-541    AC A0A251PIE9.1
#=GS B8B039_ORYSI/231-404        AC B8B039.1
#=GS A0A0E0L0B6_ORYPU/323-510    AC A0A0E0L0B6.1
#=GS A0A0D3G0D1_9ORYZ/297-477    AC A0A0D3G0D1.1
#=GS A0A0D3GXC3_9ORYZ/351-529    AC A0A0D3GXC3.1
#=GS A0A0G2K121_RAT/47-207       AC A0A0G2K121.1
#=GS G8NVH0_GRAMM/46-192         AC G8NVH0.1
#=GS C5C032_BEUC1/3644-3796      AC C5C032.1
#=GS F0SA46_PSESL/711-884        AC F0SA46.1
#=GS A0A1Q5N1R0_9ACTN/1024-1183  AC A0A1Q5N1R0.1
#=GS A0A1G8BNN1_9ACTN/1025-1180  AC A0A1G8BNN1.1
#=GS K4B8F6_SOLLC/422-606        AC K4B8F6.1
#=GS A0A059BBL9_EUCGR/352-525    AC A0A059BBL9.1
#=GS A0A2G2WW61_CAPBA/460-639    AC A0A2G2WW61.1
#=GS A0A0D9ZWB4_9ORYZ/1269-1452  AC A0A0D9ZWB4.1
#=GS A0A2I4FE88_9ROSI/423-608    AC A0A2I4FE88.1
#=GS A0A0E0LS99_ORYPU/337-524    AC A0A0E0LS99.1
#=GS A0A287VT42_HORVV/97-282     AC A0A287VT42.1
#=GS K4B8F5_SOLLC/320-500        AC K4B8F5.1
#=GS A0A2K2CCU5_POPTR/143-288    AC A0A2K2CCU5.1
#=GS A0A0D3DVZ5_BRAOL/73-218     AC A0A0D3DVZ5.1
#=GS A0A239AT18_9PROT/740-892    AC A0A239AT18.1
#=GS A0A287MBX4_HORVV/400-587    AC A0A287MBX4.1
#=GS A0D555_PARTE/21-188         AC A0D555.1
#=GS A0A087HRQ3_ARAAL/378-560    AC A0A087HRQ3.1
#=GS A0A1Z4M208_9CYAN/477-617    AC A0A1Z4M208.1
#=GS A0A0E0EJ16_9ORYZ/333-430    AC A0A0E0EJ16.1
#=GS E8UXA6_TERSS/1313-1459      AC E8UXA6.1
#=GS A0A1U7Z210_NELNU/239-384    AC A0A1U7Z210.1
#=GS M4EI00_BRARP/1-85           AC M4EI00.1
#=GS A0A251TVX5_HELAN/404-593    AC A0A251TVX5.1
#=GS A0A1Z5RF05_SORBI/433-622    AC A0A1Z5RF05.1
#=GS M0TA89_MUSAM/387-569        AC M0TA89.1
#=GS A0A2G3D535_CAPCH/407-594    AC A0A2G3D535.1
#=GS A0A0S1SFC3_9FLAO/986-1156   AC A0A0S1SFC3.1
#=GS V4KDU6_EUTSA/173-305        AC V4KDU6.1
#=GS A0A0E0L0C6_ORYPU/334-521    AC A0A0E0L0C6.1
#=GS A0A058ZUF1_EUCGR/320-509    AC A0A058ZUF1.1
#=GS A0A0H5CLH6_9PSEU/1022-1173  AC A0A0H5CLH6.1
#=GS A0A0K9NIY7_ZOSMR/227-401    AC A0A0K9NIY7.1
#=GS A0A0D3H5M0_9ORYZ/348-533    AC A0A0D3H5M0.1
#=GS A0A0E0QFJ0_ORYRU/252-429    AC A0A0E0QFJ0.1
#=GS F6I241_VITVI/29-127         AC F6I241.1
#=GS A0A0D2STZ5_GOSRA/403-592    AC A0A0D2STZ5.1
#=GS A0A072TPJ1_MEDTR/313-496    AC A0A072TPJ1.1
#=GS U5FVI7_POPTR/1-118          AC U5FVI7.1
#=GS D9VUU2_9ACTN/612-768        AC D9VUU2.1
#=GS A0A1X7A6D7_9RHOB/2500-2667  AC A0A1X7A6D7.1
#=GS A0A1B1PPZ1_9RHOB/938-1092   AC A0A1B1PPZ1.1
#=GS A0A085ZGH3_9FLAO/723-898    AC A0A085ZGH3.1
#=GS A0A0E0AS43_9ORYZ/1233-1412  AC A0A0E0AS43.1
#=GS B7GBI8_PHATC/219-368        AC B7GBI8.1
#=GS A0A1H7ATN8_9BACT/1386-1543  AC A0A1H7ATN8.1
#=GS A0A2I4G940_9ROSI/299-488    AC A0A2I4G940.1
#=GS B0W522_CULQU/35-198         AC B0W522.1
#=GS A0A251PIH8_PRUPE/402-590    AC A0A251PIH8.1
#=GS A0A0D3GXB6_9ORYZ/328-512    AC A0A0D3GXB6.1
#=GS B8B035_ORYSI/196-366        AC B8B035.1
#=GS A0A074YXJ9_9TREM/25-185     AC A0A074YXJ9.1
#=GS A0A0E0DNY9_9ORYZ/340-527    AC A0A0E0DNY9.1
#=GS A0A1V1ZHP6_9FLAO/671-841    AC A0A1V1ZHP6.1
#=GS A0A0P1EKR4_9RHOB/1218-1360  AC A0A0P1EKR4.1
#=GS A0A1G7SXW5_CHIFI/935-1102   AC A0A1G7SXW5.1
#=GS A0A078H695_BRANA/402-585    AC A0A078H695.1
#=GS M1CSF9_SOLTU/333-518        AC M1CSF9.1
#=GS A0A287MC13_HORVV/8-96       AC A0A287MC13.1
#=GS A0A2H3YAK1_PHODC/420-602    AC A0A2H3YAK1.1
#=GS A0A1D2IK45_9ACTN/162-302    AC A0A1D2IK45.1
#=GS I1PTV3_ORYGL/331-521        AC I1PTV3.1
#=GS A0A1H7ATN8_9BACT/1227-1379  AC A0A1H7ATN8.1
#=GS B9S8G2_RICCO/30-111         AC B9S8G2.1
#=GS A0A1C3MWW7_9ACTN/1330-1482  AC A0A1C3MWW7.1
#=GS A0A183TH81_SCHSO/25-187     AC A0A183TH81.1
#=GS A0A2K1R986_POPTR/19-207     AC A0A2K1R986.1
#=GS A0A0P7YVV3_9TELE/14-144     AC A0A0P7YVV3.1
#=GS A0A251RTL4_HELAN/401-605    AC A0A251RTL4.1
#=GS A0A1D6JL40_MAIZE/84-229     AC A0A1D6JL40.1
#=GS X7FAL4_9RHOB/4360-4471      AC X7FAL4.1
#=GS A0A0E0H5Z5_ORYNI/278-458    AC A0A0E0H5Z5.1
#=GS A0A183RCA8_9TREM/18-178     AC A0A183RCA8.1
#=GS A0A2H3ZSJ8_PHODC/170-352    AC A0A2H3ZSJ8.1
#=GS A0A2I4BTF2_9TELE/37-197     AC A0A2I4BTF2.1
#=GS A0A1G6NHW5_9PSEU/1031-1176  AC A0A1G6NHW5.1
#=GS A0A0D3CK35_BRAOL/375-558    AC A0A0D3CK35.1
#=GS D7TSV8_VITVI/261-459        AC D7TSV8.1
#=GS A0A183FLU4_HELBK/11-84      AC A0A183FLU4.1
#=GS A0A0E0DIE0_9ORYZ/1212-1400  AC A0A0E0DIE0.1
#=GS A0A1G9TZL2_9EURY/1208-1374  AC A0A1G9TZL2.1
#=GS A0A0E0A5K9_9ORYZ/251-431    AC A0A0E0A5K9.1
#=GS A0A1M5E4F9_9FLAO/725-900    AC A0A1M5E4F9.1
#=GS A0A0D2TR22_GOSRA/1-64       AC A0A0D2TR22.1
#=GS B7RZR7_9GAMM/43-183         AC B7RZR7.1
#=GS A0A1U8MRR3_GOSHI/398-581    AC A0A1U8MRR3.1
#=GS A0A1S2XLZ7_CICAR/409-596    AC A0A1S2XLZ7.1
#=GS A0A0D3CK30_BRAOL/443-626    AC A0A0D3CK30.1
#=GS F1RJI1_PIG/45-205           AC F1RJI1.1
#=GS A0A0N5DEL6_TRIMR/21-181     AC A0A0N5DEL6.1
#=GS A0A287J3S7_HORVV/394-581    AC A0A287J3S7.1
#=GS A0A099CV76_9GAMM/714-857    AC A0A099CV76.1
#=GS A0A0D3ATQ4_BRAOL/218-397    AC A0A0D3ATQ4.1
#=GS G8NWX2_GRAMM/582-736        AC G8NWX2.1
#=GS A0A0K9QVR5_SPIOL/382-564    AC A0A0K9QVR5.1
#=GS A0A0E0HBK1_ORYNI/246-435    AC A0A0E0HBK1.1
#=GS A0A0E0H5Z1_ORYNI/1230-1417  AC A0A0E0H5Z1.1
#=GS A0A0E0AS44_9ORYZ/298-485    AC A0A0E0AS44.1
#=GS A0A251UEQ2_HELAN/116-245    AC A0A251UEQ2.1
#=GS A0A1I1A035_9CELL/205-349    AC A0A1I1A035.1
#=GS A0A1S3ZPT2_TOBAC/403-587    AC A0A1S3ZPT2.1
#=GS A0A1D6S5S9_WHEAT/410-595    AC A0A1D6S5S9.1
#=GS A0A0E0DID8_9ORYZ/1227-1415  AC A0A0E0DID8.1
#=GS A0A251S295_HELAN/410-594    AC A0A251S295.1
#=GS D7TF32_VITVI/1-51           AC D7TF32.1
#=GS A0A0E0AS40_9ORYZ/19-206     AC A0A0E0AS40.1
#=GS A0A2G3CJX2_CAPCH/479-657    AC A0A2G3CJX2.1
#=GS A0A0D0W240_9ACTN/469-628    AC A0A0D0W240.1
#=GS A0A059A2K4_EUCGR/1-120      AC A0A059A2K4.1
#=GS M0S8R9_MUSAM/301-495        AC M0S8R9.1
#=GS A0A287MBY2_HORVV/5-77       AC A0A287MBY2.1
#=GS A0A0N0AE58_9ACTN/1903-2050  AC A0A0N0AE58.1
#=GS A0A059A2P4_EUCGR/47-169     AC A0A059A2P4.1
#=GS A0A183KXU4_9TREM/18-178     AC A0A183KXU4.1
#=GS A0A183IYV8_9BILA/8-169      AC A0A183IYV8.1
#=GS A0A2K2CAG6_POPTR/385-567    AC A0A2K2CAG6.1
#=GS A0A087H0S7_ARAAL/405-589    AC A0A087H0S7.1
#=GS D6D872_9BACE/711-885        AC D6D872.1
#=GS A0A067ETW8_CITSI/414-601    AC A0A067ETW8.1
#=GS A0A2K1WMN1_POPTR/389-573    AC A0A2K1WMN1.1
#=GS G5AWX1_HETGA/44-204         AC G5AWX1.1
#=GS A0A1I6H3C2_9FLAO/1034-1179  AC A0A1I6H3C2.1
#=GS W1NV62_AMBTC/114-260        AC W1NV62.1
#=GS A0A1S2XGF8_CICAR/400-586    AC A0A1S2XGF8.1
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