#=GF ID   MapZ_EC1
#=GF AC   PF18041.5
#=GF DE   MapZ extracellular domain 1
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF06430
#=GF GA   33.10 33.10;
#=GF TC   33.80 33.80;
#=GF NC   33.00 33.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   27346279
#=GF RT   Structure-function analysis of the extracellular domain of the
#=GF RT   pneumococcal cell        division site positioning protein MapZ.
#=GF RA   Manuse S, Jean NL, Guinot M, Lavergne JP, Laguri C, Bougault CM,
#=GF RA   VanNieuwenhze MS, Grangeasse C, Simorre JP;
#=GF RL   Nat Commun. 2016;7:12071.
#=GF DR   INTERPRO; IPR041295;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the extracellular domain 1 (MapZextra1) found in
#=GF CC   Streptococcus pneumoniae cell division site positioning protein
#=GF CC   MapZ. MapZ ensures accurate placement of the bacterial division
#=GF CC   site. The domain is a rigid four alpha-helices with two flexible
#=GF CC   linkers. The N-terminal end of MapZextra1 is connected to the
#=GF CC   trans-membrane segment of MapZ whilst the C-terminal is linked
#=GF CC   to MapZextra2 via a serine rich linker (SRL).The highly
#=GF CC   conserved residues are not accessible at the surface but are
#=GF CC   directly involved in many inter-helices interactions allowing
#=GF CC   for rigidity [1].
#=GF SQ   97
#=GS A0A2X3VDS3_9STRE/207-337  AC A0A2X3VDS3.1
#=GS F9VCG7_LACGL/308-434      AC F9VCG7.1
#=GS A0A172Q8M4_9STRE/202-333  AC A0A172Q8M4.1
#=GS S0NJW7_9ENTE/223-351      AC S0NJW7.1
#=GS Q99YL6_STRP1/217-348      AC Q99YL6.1
#=GS B9DV59_STRU0/210-340      AC B9DV59.1
#=GS G5K4F2_9STRE/198-328      AC G5K4F2.1
#=GS A0A1L8RHM2_9ENTE/357-480  AC A0A1L8RHM2.1
#=GS A0A1Q8E5F3_9STRE/176-303  AC A0A1Q8E5F3.1
#=GS A0A6I2GJB7_9LACT/27-153   AC A0A6I2GJB7.1
#=GS A0A139NNE7_9STRE/213-340  AC A0A139NNE7.1
#=GS A0A2A5RPR7_9LACT/368-495  AC A0A2A5RPR7.1
#=GS R2S8D4_9ENTE/417-544      AC R2S8D4.1
#=GS K8ZQC8_9ENTE/469-596      AC K8ZQC8.1
#=GS A0A0E4H4X7_9STRE/187-314  AC A0A0E4H4X7.1
#=GS T0VDS1_9ENTE/301-426      AC T0VDS1.1
#=GS G5JRG1_STRCG/202-334      AC G5JRG1.1
#=GS A0A224XBQ8_9LACT/240-369  AC A0A224XBQ8.1
#=GS Q5M644_STRT2/323-454      AC Q5M644.1
#=GS E1M8B8_9STRE/202-270      AC E1M8B8.1
#=GS A0A7X1ZBB5_9LACT/275-401  AC A0A7X1ZBB5.1
#=GS A0A6A0B4F4_9LACT/276-403  AC A0A6A0B4F4.1
#=GS S1N6T9_9ENTE/279-413      AC S1N6T9.1
#=GS A0A1L8TQR2_9ENTE/335-463  AC A0A1L8TQR2.1
#=GS A0A139NMA5_9STRE/216-343  AC A0A139NMA5.1
#=GS A0A0R2N1F3_9LACO/19-127   AC A0A0R2N1F3.1
#=GS A0A4P5P4N6_9ENTE/158-286  AC A0A4P5P4N6.1
#=GS A0A377KNB1_9ENTE/349-477  AC A0A377KNB1.1
#=GS F9PWV1_9STRE/27-154       AC F9PWV1.1
#=GS A0A6G8AMR3_9ENTE/192-321  AC A0A6G8AMR3.1
#=GS S1R2R9_9ENTE/266-395      AC S1R2R9.1
#=GS A0A6A0BC88_9LACT/246-375  AC A0A6A0BC88.1
#=GS A0A3L9DVZ4_9STRE/181-312  AC A0A3L9DVZ4.1
#=GS A0A369B284_9ENTE/195-323  AC A0A369B284.1
#=GS F5X522_STRPX/230-360      AC F5X522.1
#=GS A0A1L8QX54_9ENTE/322-450  AC A0A1L8QX54.1
#=GS A0A3L8GD12_STRIN/201-331  AC A0A3L8GD12.1
#=GS A0A430ARG9_9ENTE/163-290  AC A0A430ARG9.1
#=GS A0A429ZU02_9ENTE/147-275  AC A0A429ZU02.1
#=GS E1M8B9_9STRE/2-65         AC E1M8B9.1
#=GS A5M9U7_STREE/186-312      AC A5M9U7.1
#=GS A0A430B561_9ENTE/206-334  AC A0A430B561.1
#=GS A0A2L0D628_9STRE/192-322  AC A0A2L0D628.1
#=GS Q9CF31_LACLA/363-490      AC Q9CF31.1
#=GS A0A2C9XPT1_9ENTE/332-459  AC A0A2C9XPT1.1
#=GS A0A7X6S047_9STRE/166-294  AC A0A7X6S047.1
#=GS Q834V8_ENTFA/338-465      AC Q834V8.1
#=GS MAPZ_STRR6/186-312        AC Q8DR55.1
#=GS A0A1E5KTI2_9ENTE/321-449  AC A0A1E5KTI2.1
#=GS S0KTD6_9ENTE/325-453      AC S0KTD6.1
#=GS F2I780_AERUA/28-141       AC F2I780.1
#=GS A0A179EQ24_ENTTH/393-520  AC A0A179EQ24.1
#=GS A0A1G6CFC0_9STRE/199-330  AC A0A1G6CFC0.1
#=GS A3CPY0_STRSV/213-340      AC A3CPY0.1
#=GS I3U125_ENTFD/349-476      AC I3U125.1
#=GS A0A239SWJ6_9STRE/182-308  AC A0A239SWJ6.1
#=GS A0A387BAD4_9LACT/287-414  AC A0A387BAD4.1
#=GS Q8E1P9_STRA5/210-341      AC Q8E1P9.1
#=GS A0A1J0A5U7_9ENTE/169-298  AC A0A1J0A5U7.1
#=GS A0A430A5E0_9ENTE/356-485  AC A0A430A5E0.1
#=GS A0A1L8WL85_9ENTE/360-487  AC A0A1L8WL85.1
#=GS A0A242KC19_9ENTE/342-469  AC A0A242KC19.1
#=GS F3YAR8_MELPT/307-435      AC F3YAR8.1
#=GS J0VE70_STREE/25-151       AC J0VE70.1
#=GS G6EQJ7_STRTR/323-454      AC G6EQJ7.1
#=GS A4VTE7_STRSY/203-330      AC A4VTE7.1
#=GS A0A1E5H102_9ENTE/334-461  AC A0A1E5H102.1
#=GS A0A2R5HH01_9LACT/246-368  AC A0A2R5HH01.1
#=GS R2PVY1_9ENTE/215-343      AC R2PVY1.1
#=GS A0A430A2A4_9ENTE/171-302  AC A0A430A2A4.1
#=GS A0A4S3B6J6_9ENTE/233-363  AC A0A4S3B6J6.1
#=GS A0A430AIN0_9ENTE/26-156   AC A0A430AIN0.1
#=GS A0A4Y9FKC9_9STRE/210-336  AC A0A4Y9FKC9.1
#=GS A0A3P1VC64_9STRE/193-320  AC A0A3P1VC64.1
#=GS G5KCQ3_9STRE/223-353      AC G5KCQ3.1
#=GS A0A380KZA9_9STRE/219-345  AC A0A380KZA9.1
#=GS Q8DVK9_STRMU/207-337      AC Q8DVK9.1
#=GS A0A4P5PD82_9ENTE/169-297  AC A0A4P5PD82.1
#=GS A0A4D7CVK5_9ENTE/642-771  AC A0A4D7CVK5.1
#=GS A0A841C687_9LACT/382-509  AC A0A841C687.1
#=GS A0A1E8GR04_9LACT/216-345  AC A0A1E8GR04.1
#=GS A8AVU7_STRGC/189-315      AC A8AVU7.1
#=GS A0A1T4K3M8_9ENTE/223-350  AC A0A1T4K3M8.1
#=GS A0A430AZY1_9ENTE/175-305  AC A0A430AZY1.1
#=GS E6LF79_ENTI1/265-393      AC E6LF79.1
#=GS A0A380K5B9_9STRE/202-332  AC A0A380K5B9.1
#=GS S0RPN3_ENTAV/249-377      AC S0RPN3.1
#=GS A0A1Q2D3A7_9ENTE/221-355  AC A0A1Q2D3A7.1
#=GS V6Q3M2_9ENTE/126-256      AC V6Q3M2.1
#=GS A0A2A5RZQ7_9LACT/293-419  AC A0A2A5RZQ7.1
#=GS A0A5C5T7U7_9STRE/201-331  AC A0A5C5T7U7.1
#=GS R3W684_9ENTE/284-412      AC R3W684.1
#=GS C9AAM6_ENTCA/272-399      AC C9AAM6.1
#=GS T1ZEM9_STRIT/226-353      AC T1ZEM9.1
#=GS S0L6Q0_9ENTE/355-483      AC S0L6Q0.1
#=GS A0A4R0QM86_9STRE/177-304  AC A0A4R0QM86.1
#=GS A0A139NGT6_9STRE/223-353  AC A0A139NGT6.1
A0A2X3VDS3_9STRE/207-337             ............t-TTTTTSSSSKTSAKANSQSFKKSYAAFFTDSE.KT..KLKNSAF-ANLPSLEKILNKLK..N.......TSYYTNAKKQYDSLKRQIAAINLVNGKF..KT....NAIVDGE-Q.KTATVKDD.A.N.FDDIsd...ddLNTGN..ATLDALLKSVVA-d.................
F9VCG7_LACGL/308-434                 ............n-NNEKAVNQAAVENKANLNAFNKAYDEFFTDAD.HQ..VLKNSNF-DQLSALKNKLKTLK..G.......SD-FDTAETKVNALETQIKAVEKVNALF..NK....SAIVDGELN.KEAQVKAA.V.S.IPAV.......PKTEN..EKLNKVLAQAINM..................
A0A172Q8M4_9STRE/202-333             ...........as--TSSTASSSKDSTKEAADEFDSLYQSFFADDQ.QT..LPKNSEF-TNLSKLETALKQLA..D.......TDYYKDAKSKYDKLSRQIKAVQAVNGKF..TS....DAIADGKQV.ESAAVKSD.A.N.FDDLss...etLNTGN..ASLDTLLQKVIA-a.................
S0NJW7_9ENTE/223-351                 ............k-EKAEAARQEQLRVETAVARIESELDNFYLDQD.EQ..FIVPGKTAADVEKLMKELEEYS..S.......EPKYKELRDKGQKLQVKIAVLDQINSHF..TE....PIVVGDELK.ENVHVKDG.D.A.VDMA.......LLTDE..TPFSKLINEAIK-k.................
Q99YL6_STRP1/217-348                 .........ktsl---QTDSAKKATRLKAAAKAFEKLYGTFYTDAT.KS..KLKNSAF-ATLPDLEAALKALE..G.......SAYYDKAKAKVDSLKKAIAAITAVNGKF..VS....DVVVDGE-K.VSAEVKAD.A.N.FDDLss...atLTIGN..ANLDAVLQASIT-e.................
B9DV59_STRU0/210-340                 ............s-QQSSSKDSKASLAKKAYKAFDKGLKAFYLDDE.MT..KLKNSEM-THLDDLTKKLDALK..N.......TNYYDKAKEKWESLKKQITAIQTVNGKF..ST....EAIKDGQ-K.TAATIKSD.A.N.FDDFta...dsLKTGN..ATLDKLLQEVVS-d.................
G5K4F2_9STRE/198-328                 ...........qk--PKASKKSASNKAKTNAKAFEQLYSSFYTDAD.KT..TLKNSQF-DKLPDLEASLKALK..G.......TAYYDKAKDELATLKKQITAIQAVNAKF..MT....DAIVDGE-K.VEASVKTD.A.N.FDDLas...etLSTGN..ASLDSLLQASVT-a.................
A0A1L8RHM2_9ENTE/357-480             ...........ah--QHQAQQQQAATEAKALETFQSLLNSFYTADG.V-..YLRENGP--SLAELQQDFTKLT..K.......TQ-QTAQQPAMDELEEKQAASQTVNKLF..TE....PVLVGSDVK.DGLLASAT.A.A.IPED.......-FTGT..DAFYKKANQAL--aa................
A0A1Q8E5F3_9STRE/176-303             ............s-TSTSQSSSSSSKEDGAVTAFNSLYATFFTDKE.QT..KLKNSEF-GKLPELKKALDKIN.aK.......TSAYQTAKKKYESLETAIKAVQALNAQF..DK....PIIVDGELD.TTATVKDG.E.N.LSPT.......-ATGM..TAVDAKITAAIN-l.................
A0A6I2GJB7_9LACT/27-153              ......lessskt--------DRPTVTNNVSQTVQKKIAELYIDEE.TG..FIQEDITEEYVESLRTEIDDLN.eS.......TLDKNVLNRQLDEIVHRVEAKEAVNGFYpeET....PAIKANQVA.ENLSFKEG.L.T.IEQV.......-----..-------------eevkekyyfvleea....
A0A139NNE7_9STRE/213-340             ............t-TSSTSTTASSSQEQQLLEEFNKSYATFFTDSQ.QT..KLKNSEF-SKLSSLQAILDKMD.kN.......SEAYKTAKAKLDQLTSAIRATEKINQQF..SG....NLIVDGKLD.TTVQVKSG.A.D.LSFS.......-ASGL..TSVDNLLTSAVN-f.................
A0A2A5RPR7_9LACT/368-495             .......qktipv------KTSQSSSKLSALAQFNKDYDEYYLDSD.HS..VLRNSKF-GQLTNLSNDLDKIS..S.......NKEKQAAKSKYETLKSEIDAINLINGLF..DS....AVINDGKIV.SGATLKSG.V.A.LPSL.......PKTTN..SKLNNLLKQAL--ee................
R2S8D4_9ENTE/417-544                 ............a-QEQKQAQAKAKALAAELKGLKKSVADLYLNDD.KD..FLKAGLTSAEVTGVLKQVEDFS..D.......TSKTKDLKAELTDIQEKLALQDQVNGLY..TK....PVISGDVFT.KEVAIATT.E.K.IDLD.......-ITGD..DPFDQLLAEGV--qa................
K8ZQC8_9ENTE/469-596                 ...........hl-------QKEHTEVQQAYRKIERQIDDYYVGDK.AKdgFVAKNMSAKTIANVKDEIADLEkkD.......PEKASDLTKQLQELQKNTELTNKINDLF..VS....PILKGDKI-.EKVGLKDN.V.K.VEFV......pVKNPS..TPFEKAVNECI--ld................
A0A0E4H4X7_9STRE/187-314             ...........ss--DSTTETTESNPTDPNVSAFEKLYASFFTDGS.LT..KLKNSEF-DKLDQLKAALDKIG.kS.......SSGYKAAKAKYDALEKAIKSIKTINANF..DK....PAIVDGELD.TTANVKSD.A.K.FDSV.......-STGL..SAVDALLTSAINM..................
T0VDS1_9ENTE/301-426                 ............y---EETARQEQIATASELDQIEADLADFYTDDN.QG..FIKADKTTMQLTALTDRLAKYK..T.......ESRYPDLLAQSETIKEKMATLSEINGYF..TS....PVIIEDQL-.QKVSLKEP.S.A.VTMS.......KRTAE..TPFDQLVNRAIDQ..................
G5JRG1_STRCG/202-334                 .......ttvssg-----ASAKGKDDGKTDYKAFQKSYKSFFIDDK.QT..QLKNSQF-SQLINLNKTLKKLD..G.......TTYYKDAKSDYSSLNKQITAIKTVNKLF..DK....DIIVDGKLA.ADAKAKKE.A.D.FDKLtd...dtLKTGN..STLDKLIQEAIK-k.................
A0A224XBQ8_9LACT/240-369             ........qkqat--QTEKLEAKKSEEAKKTAAFNKVYATFFVDDK.AT..KLKNDQF-DHIDKLTGELDKLK..N.......QSDYKTLQAKVAELKSEISAIKAMNGNF..DK....AVIKDGVLD.KSVQVREG.A.K.LSYT.......-ATEN..DALNILLKDAVA-h.................
Q5M644_STRT2/323-454                 ..........ass---AVISSSSKGASASDNKAFEDMYKNFFTDDE.QT..KLANDQF-GKLSDLEKLLKKLE..K.......TKYYDAAKTKYDNLKKQIEAIEKVNSKY..ES....DALVDGSYN.ASISVKSD.A.N.FNDLse...rvTNTGN..ASLDSIIQEVIK-g.................
E1M8B8_9STRE/202-270                 ..........qei--QSQSSDAGLVSNQAILDQFNSLYDTFYTDEN.KT..ALKNSQF-SQLSQLKELLDKLE..G.......AKEHTLAKSK------------------..--....---------.--------.-.-.----.......-----..-------------i.................
A0A7X1ZBB5_9LACT/275-401             ........nhtqp-----VKTTQASKTSSAWSKFNQEYKNFFIDSA.QT..ELRNREF-SQLNQLSNQMNQVT..N.......ASEHSKAQKKYDTLKTQVDAINQVNGLF..EN....DVINDGTL-.SHGTLKAG.A.T.LFAT.......PTTSN..AKLNRLLNEAMT-d.................
A0A6A0B4F4_9LACT/276-403             ..........ksv--QASKTEDKKSAAAQKTAAFNKVFASFFTDNK.QT..KLKNSVF-GKVAELDKSLATLK..N.......QSNYKQKKAKVDALKAEIAATQALNAKF..DK....PAITDGELD.KTATVKKG.E.T.ISYT.......-ATEN..ESLNTLLQAAVAQ..................
S1N6T9_9ENTE/279-413                 ............q-NVKAQAQQEQQKIEKQETAIQTQLADFYTDNT.HQ..FIKSDKTANQLADLTTQVNNLK..EaaksagtKDNTEELTNEIKSIQEKMDIITQVNNLF..ET....PVVRGSEI-.KPATAIKG.S.T.IDIE.......PLTTD..DEFSKTINNVIS-d.................
A0A1L8TQR2_9ENTE/335-463             ...........ke--VEAQRVATVKKDNESLDAIEESINDYYTTDD.KT..YIAADKLDLNTAKIDEELAGYK..T.......NKRYDGLKKEYAELVAKQKAEQAVNQLF..TS....AAIDGDKMV.EKPLLKTA.E.S.VDLT.......VATGD..KDFDALMDQAIN-n.................
A0A139NMA5_9STRE/216-343             ...........qt-SSEATTSGSLSEEETNKKSFDDLYATFFTDGN.QT..ALKNSAF-GNLESLKAILDKLQ..G.......TASYDAAKQQYDNLVKQVSAIQTVNGQF..TT....AAITDGVLD.INAQAKSD.A.V.FADT.......-TTGN..AEIDKVLNQAVEQ..................
A0A0R2N1F3_9LACO/19-127              ........rqqvn-------TLQQQQMTQTEKRVDQQLTQLYTDPK.LG..YFKRTTTATQLTAIAQNLDKLS..Q.......SDQQATLQDRYTQAKTAFELQTTLNAAF..QK....PVLEGDQLH.SDR-----.-.-.----.......-----..-------------likhtmteskf.......
A0A4P5P4N6_9ENTE/158-286             ............k-EAEAQRIAALEKDNKACDQVEKKIKQFYLDQD.QT..YVDPEMVWQDREALEKELKQVK..D.......TKRYDQLKASYDRLVEKTEQLKEVNFLF..TH....RAIQGDELS.SEMTLKRD.M.P.VNLT.......VDTGD..EAFDQLLNEAVRQ..................
A0A377KNB1_9ENTE/349-477             .........qqtv---QAQIAAEAKKQQQKVNELKKTLATFYYDGA.HQ..FLRTSMINQDLTKLKTSLNEVK..G.......EKGYADLEKTYEDIQTKVKDIKGVNELF..TT....EAIIDHHLA.DDLKLKAD.Q.E.IKRF.......-ATDD..SDFGQLLKKA---qde...............
F9PWV1_9STRE/27-154                  ..........qel--QTKAADSGLVSKQSVYEQFNTLYDTFYTDEN.KT..ALKNSQF-GQLNQLKELLDKLE..G.......AREQTLAKSKYDSLETQIKAIQEVNSQF..ET....PAITDGVLD.TNAKIKAD.A.K.FTDV.......-KTGN..TEIDKLLDKAIS-l.................
A0A6G8AMR3_9ENTE/192-321             ...........ky--QETTGGQSKTEMTQHADLAETHLNELYLNES.KV..FLSEDFNAEKLEKVVDEVAELK..N.......KDLKADLEEQLTAVQAKAEKQFEVNNLF..KE....GIIKGDKLS.EKPVFKTSlN.K.VPVT.......IEDPK..DDFETLVNQ----gltv..............
S1R2R9_9ENTE/266-395                 .............QRQDTNKSQVTQKADSQLSKLSVKVTQLFTTNK.VE..FLKATVTLAQIDDLSNQLEKYK..D.......DKGYTKLHQQLASAKQQWQKVSEVNGYF..TS....PIIENGQLK.EQATLDYS.Q.K.FAVK......aIANPQ..EPYEKLVNEAVA-i.................
A0A6A0BC88_9LACT/246-375             .........kqtv--QTSKSQAKQSEEAEKTAAFNKVYASFFIDDK.ET..KLKNSEFSDYKTKLTAALAKVN..G.......QSNEKTLEAKVEELKAQIVAVQKMNADF..DK....AVIVDGALD.KTAKVKEG.V.T.LSFT.......-ATEN..TALNNLLKEAVA-l.................
A0A3L9DVZ4_9STRE/181-312             ...........te-STTEAKQEVSKKEKQNLEAFNKKYAAFFVDEG.QS..KLKNSEF-GKVSELENLLKALE..G.......SSYYNDAKTKFERLNKSIKAVQSVNDKF..ES....EAIVDGE-K.VVANLKSN.A.S.LDDLta...atLNTGN..ATLDTLLQAVVA-e.................
A0A369B284_9ENTE/195-323             ............y--SNEQDKAAEKDRVALIDSTEKELDSLFSSKD.KV..FLKNDIKEADFKKAQEELDKLK..T.......KDGYDNLKELFDEAEDKFNKQEKMNALF..KS....PIMVGKELK.ENVLVKNS.S.P.ITLT......rVSEEK..DGFDILFNKAF--de................
F5X522_STRPX/230-360                 ............t-TKKSTSSSSSAVAKKAKRAFDDAYAAFFTDDT.KT..KLKNSEF-DNISSLKEKLDDLK..D.......TDYYDDAKKEYDTLAAQITAIQTINALY..ES....NVIVNGE-K.ASATVKSD.A.N.FDNLss...dlLNTGN..ANLDTLLQSAIT-d.................
A0A1L8QX54_9ENTE/322-450             .............KQKSEAAQQAQLQQTQDFAELSAELQDFYLDAQ.QQ..FIKPEKTLAQLKPLMEQVSTFK..Q.......QENYADVQAFSQALYQKMTTLENINQYF..TA....PMIVGDTLD.RTVHIKEM.Q.L.IDVT.......LPNQE..GAFWDLADEAVQ-l.................
A0A3L8GD12_STRIN/201-331             ..........vae---QEKENEQAKKAKANAKAFNSELKAFYSDDK.QT..KLKNDHF-DKLTDLEKILSKLK..K.......TAYYDNAKEKFDLLSKQIVAIKAVNGKF..AT....EVIKDGE-K.IAATVKSG.V.H.FDDLqa...diLKTGN..ASLDSMLQSAIS-d.................
A0A430ARG9_9ENTE/163-290             ..........nsy-----QKKVAAEELEKKVELATNAMDRLYTDAD.HV..FLKEGIAEEDVAAAEKAVNKVK..G.......EKPFAELNERLTAITAQFELLNGVNHLF..KT....PAIDGRKLS.DESYVVDD.S.E.LTLD......kIAHPE..NEFDELINAALT-e.................
A0A429ZU02_9ENTE/147-275             ..........syq---GKAQEKAAADLAKEVALLENNFNKLYFNEE.KV..FLNEDASEASLDKLTKEVATLK..D.......EKVQGEFDPMIEDLSHKIELQTALNQLF..IS....PVIKGDKLA.DKPVLKDE.E.P.VYPQ......eIKTPE..NKFEELINQGI--l.................
E1M8B9_9STRE/2-65                    ............q---------------------------------.--..----------------------..-.......-------NQKYDSLETQIKAVQDVNAQF..ET....PAITDGVLD.TNAKVKAD.A.K.FTEV.......-KTGN..TEIDKLLDKAIS-l.................
A5M9U7_STREE/186-312                 ...........st--KEIETSQSTTANQSDVDDFNTLYDAFYTNSN.KT..ALKNSQF-DKLSQLKTLLDKLE..G.......SREHTLAKSKYDSLATQIKAIQDVNAQF..EK....PAIVDGVLD.TNAKAKSD.A.K.FTDI.......-KTGN..TELDKVLDKAIS-l.................
A0A430B561_9ENTE/206-334             ...........ys---AQQKKAEEKATTELVSTAELDLNSLYSTSE.HV..FLKKDISSKDIDKAKKSLDKLK..G.......KDDYNEMKKEFDQVEEKYNKQTAINDLF..KS....PIIEGDKLD.TKTFVKNE.D.H.ISIN......kIATEK..DGFDILYNKA---fae...............
A0A2L0D628_9STRE/192-322             .......pldssg-------KNASAQAIKDNEAFSKMYDGFFIDDK.AL..KLKNSEF-GKLPELEAALKKLE..G.......TKFYDAAKEKYDNLKEQIDGIQAVNAKF..DK....DVIVDGELV.DSAKPKAD.A.N.FDDLsv...etLNTGN..ATLDNLLQKAVK-k.................
Q9CF31_LACLA/363-490                 .........shqk----GKTVQTSQSSQSDLDKYQKQYDAFFTDKS.HT..ILRNSQF-SKLSALETLVDAHK..N.......SMAWSNAVSDTESLKDQINAIKKVNALF..TS....AAITDGKLD.SSAKVVAN.V.K.VPET.......PKTTN..ETLNKLLTQAID-l.................
A0A2C9XPT1_9ENTE/332-459             ........qkvqa-----EIAAQEQRQQEKVDQLKNNLTDFYVDDA.RE..FIRTDKINQDLSKLKVSLNEVK..E.......EKEYPGLEKMYGDIQNKIKQIQSVNEWF..TN....PVIADDHLV.EEVKIKED.K.A.IRTI.......-ETDD..TAFGQLIAQA---qte...............
A0A7X6S047_9STRE/166-294             .........tstt--ASSSQTRASSSENPGLKAFEDLYASFFTDEK.QT..ALKNESF-GQLQSLETALSILE..G.......TDAYDAAKAKVDKLKAAIAATEALNAQF..DK....PVLVDGEID.TTATAKSE.A.D.FSAA.......-STGL..SSVDAALTAAA--nf................
Q834V8_ENTFA/338-465                 ............d-QTQKAAAQEAAALTKKTDTLKDELAAFYTTKE.QV..FIKPDMVTVSPEKLSKQVAEIK..D.......SEEYSQLNKQIQTLKEKQQTIQQINQLF..EA....PIVNGNEL-.KPAILAAD.Q.P.ISVK.......KLTGN..DPFDQLMNQAIDQ..................
MAPZ_STRR6/186-312                   ...........st--KEIETSQSTTANQSDVDDFNTLYDAFYTNSN.KT..ALKNSQF-DKLSQLKTLLDKLE..G.......SREHTLAKSKYDSLATQIKAIQDVNAQF..EK....PAIVDGVLD.TNAKAKSD.A.K.FTDI.......-KTGN..TELDKVLDKAIS-l.................
A0A1E5KTI2_9ENTE/321-449             .........saae---KKIQTEQLAEQKELATSTKEALENFFTDDS.HV..YIKPGMIGNSTATIKKNLDKLK..N.......HSDYKEIKSLYDTVTNKQAEVAKVNQLF..AQ....PIINGNKL-.NDVAIIAD.K.K.IDLK.......KVEEK..DALDKLVNQAIT-e.................
S0KTD6_9ENTE/325-453                 .............QRSNTSDEKVLEQVDQQVAKLSSKIDDLYTTKQ.RN..FIKSTVTLAQINQLAKQLANFD..G.......QENYKKLKTRLEAAKEQLLAEQDINGYF..TK....AILANGKLN.HEAHIDYA.K.K.FDLQ.......LRKGK..TAFDQLANLAIKQ..................
F2I780_AERUA/28-141                  .........vmqn------QDIKQEKSDGSVEAAEKAVSALYYDDH.KT..FLKENIAKTEIEAVRRQVEGLN.rY.......SGARKDLNKQVDQVEERFKAQEGVNHLF..EKikdkPALNGATVQ.KY------.-.-.----.......-----..-------------vllnkglkeddl......
A0A179EQ24_ENTTH/393-520             ...........qk--VEAERIAEVARQEKQVSEMKQELASFYVDDT.NE..FIRTDHLNQDLPKIKQELKEVD..S.......TKDYQKLNETYNDIQEKIISIKKVNDLF..TE....PVIEDDHLV.EQPVLKNT.D.K.IEAI.......-ETDD..SAFGALIQKA---qqe...............
A0A1G6CFC0_9STRE/199-330             ...........ss-TSTSTESSSDVKAKADRNAFNDLYETFFTDEN.LT..DVKNSEF-DNLSNLEAALKKLE..G.......TDYYDDAKAKYDSLNKQITAIKAVNNLF..ES....DTIVDGN-K.VSATVKSD.A.D.IDALps...gtLNTGN..ASLDTTLQSAIS-d.................
A3CPY0_STRSV/213-340                 ...........qs-SKKSSSSSSSDNTAKNLKAFNDEYAAFFTDSN.QT..AVKNSKF-GDLEKLKTLLEKLK..G.......SKDYDAAKSKYDSLVKQISAIQSVNSQF..DG....GAITDGVLN.KEAKANTN.A.T.FSDV.......-SSGN..AKLDEVLKAAIAQ..................
I3U125_ENTFD/349-476                 .........hqkv----EAEVAAEAKRQQQMEELHEKLAAFYTDDH.HQ..FIRADMIHQDLSKLKNDLSSLK..N.......EKGYSELETTYQDIQSKIRDIQKVNEWF..IA....PAIVDDHLA.DDIKLKAD.K.E.IQAI.......-ETDN..TDFGKLIQQA---qte...............
A0A239SWJ6_9STRE/182-308             ............t-RSSASSSSSSQEESAPLKAFNELYGTFFTNDA.QT..ALKNDSF-EQLSALETALATLE..G.......TAEYESAKAKFDKLKAAIEAIQAVNGQF..DK....PVLVNGEID.TTATVKPD.V.A.FATV.......-TTGI..SSIDAAITAAVN-f.................
A0A387BAD4_9LACT/287-414             .......qhpkpv------QTAKSNSESSDLDKFNKAYDAFFTDKS.HV..ALKNNQF-TQLSTLEKMISPHK..N.......ATAWSNAVSETQDLKDQIAAINLVNALF..TK....AVITDGKFD.TTPKVISN.V.K.IPAT.......PKTGN..ETLNKLLTRAIA-l.................
Q8E1P9_STRA5/210-341                 ............s-KATTTSSEEDKKASQNLDNFNKSYANFFVDDK.KT..QLKNSEF-DKLSELEKKVDALK..G.......TKYYGKVKVKFDSLKRQIDAVKAVNDKF..KS....PAVVDGKKS.EKLEVKDG.A.N.FDSLds...ktLNTGN..ASLDSLLHSIVS-t.................
A0A1J0A5U7_9ENTE/169-298             ...........yn---SQKKQNELETTLKLTTSAEDAIQNLYMKNQgEV..FLKKGISQSDITSAEDKVKELK..G.......TEQYDKLNERMQQVVKTFTRLTAINEAF..KK....PVIEGNQLI.NDAYVKDD.T.K.LTLE......aIDPEE..NGFDKLYNEAIK-d.................
A0A430A5E0_9ENTE/356-485             ...........ky--QENIETQRLTTIKTRKENVEKNLKKLYLNDE.KI..FLSETFEEQHLNELAKEVASIE..D.......PKFVDKVSPDVEDLTARATLQGKVNDLF..ET....PLIVGDKLS.DKAALKEE.SpK.LPDA.......IKEPK..DGLEKLFNKGID-k.................
A0A1L8WL85_9ENTE/360-487             .........qnvq----AQIVAQEEAQKRKVTKLSQALAAFYTDDS.RQ..FIYTSMINQDLSKLRISLNEVK..K.......AKEYTELVKIYQDIQTKIKEIQRINELF..TA....PVILDDHLA.KEPKLKED.R.K.VQSM.......-TTVD..TAFGQLIKQA---eee...............
A0A242KC19_9ENTE/342-469             .........gdap----KQETKVEDTKKSLFEETEATLNSYFTDDK.QT..YLKPEMVSVSTQSLEKDLEKLK..K.......EDGYTDLEKTLNTIKEKQALITKVNELY..VS....PVISGSSYK.EE-AIASD.K.E.ITLE.......KETGT..DEFSKLINQAIDQ..................
F3YAR8_MELPT/307-435                 .............QEENAQHHKTEKVQTSLIKQTNQLIDAYYTDTT.HQ..FLKPDQVAVNTHKIQQNIEKLK.sN.......HSSYKNLNRRLQELKDKQSIVTQVNQWF..TQ....PIIKGNQL-.AVATMAAD.K.P.MTIK.......KLDQK..DAFSQLANQAIDQ..................
J0VE70_STREE/25-151                  ...........st--KEIETSQSTTANQSDVDDFNTLYDAFYTNSN.KT..ALKNSQF-DKLSQLKTLLDKLE..G.......SREHTLAKSKYDSLATQIKAIQDVNAQF..EK....PAIVDGVLD.TNAKAKSD.A.K.FTDI.......-KTGN..TELDKVLDKAIS-l.................
G6EQJ7_STRTR/323-454                 ..........ass---AVISSSSKGASASDNKAFEDMYKNFFTDDE.QT..KLANDQF-GKLSDLEKLLKKLE..K.......TKYYDAAKTKYDNLKKQIEAIEKVNSKY..ES....DALVDGSYN.ASISVKSD.A.N.FNDLse...rvTNTGN..ASLDSIIQEVIK-g.................
A4VTE7_STRSY/203-330                 ............t-STSQTSSTASSSTDANVTAFEQLYNSFFTDSS.LT..KLKNSEF-GKLAELKVLLEKLD.kN.......SDSYTKAKEQYDHLEKAIAAIQAINGQF..DK....EVVVNGEID.TTATVKSG.E.S.LSAT.......-TTGI..SAVDSLLASVVN-f.................
A0A1E5H102_9ENTE/334-461             .............QKNSKTEEQVAQKQDKLATQTEKELNSYFTDDK.QL..FLKPEMVGVSTKTIKENLDTLK..N.......DSNYKNLDAVYKKVMDKQAAITKINELF..AE....PIIDGSKL-.KDVAIKVD.K.K.VELT.......KRAEK..DDFDKLINQAVEQ..................
A0A2R5HH01_9LACT/246-368             ........nkpvs---------TTSTSNKSMSDFFNHYKAFFSDDK.QT..MLLNSKF-DKLPDLEKEISALK..D.......SD-QPNAKAEYKNLKEQIDAIKEVNALF..DK....PALVDGKLD.STAKVKDG.V.S.IPEM.......HNTSN..VVLNKLLSQVIEQ..................
R2PVY1_9ENTE/215-343                 ............k-EAEAQRIAAVKKENKEIDALEETIQEFYTDDK.HV..FVKADKVGQNTSKLAEEIAKHK..D.......SSRYDDLNTSYQRLLDKMNSIQKVNLLF..TA....PAINGDKLA.DNLQLKAD.Q.P.VDVT.......INTSD..QSFNELLNQAVTQ..................
A0A430A2A4_9ENTE/171-302             ..........ays---SYQKSQEQKVTAQMVASANTDVKSLFLNSE.HT..FLKKGITKSDFNKAKDALDKIK..T.......QSEFNDMNKLYEQAESIFNNQNDINDLF..KK....TVLDADNLSlDGAYVKTA.D.A.TGLKn.....lDSKDN..SAFNKLFNEALT-e.................
A0A4S3B6J6_9ENTE/233-363             ...........yq---SYSNKQEEKENQALVIASDTSVKSLFYNSE.HV..FLKDGLTESDIEKAEKQLDKIKafD.......GKEYDELAADLKQVKKKFKVQSNLNDLF..YS....PVLDGNKVN.LKAELKTA.D.S.IKLE......kIAKPK..DAFEENYNEAL--eh................
A0A430AIN0_9ENTE/26-156              .........fnqk------VKKNEVVDTHRSLDFNKKLEQLFTSRK.HL..FLAENVKKESIRTLQKEMKHTS..D.......LN----QKKLVVTAAKKLNLQNRLNQLF..DV....PIVVGEKLN.SQAKIKNN.V.N.ENNVaqlknelL----..-------------nsesqdewnklllkaldv
A0A4Y9FKC9_9STRE/210-336             ............k-KSSSSSSQDEKTVEENLKSFNTLLDSFYLSTE.KT..ALKNSSF-GDLPKLQETLNKLK..G.......TKEYDKAKEAYDQLSKEISAIQDLNAQF..ES....PVLVDGEIK.TDAKPKAN.A.T.FGDI.......-DSGN..EKLNELIKQ----glek..............
A0A3P1VC64_9STRE/193-320             ............d-STSSTSKTSSSSTDANIVAFNELYASFFTDSS.QT..KLKNSEF-DKLEQLKAALDNIG.tS.......NAGYKTAKAKYDILAKAIQAIKAMNDKF..DK....PVIVDGELD.TTATVKPG.M.S.FEAV.......-STGL..SAVDTLLTSAINM..................
G5KCQ3_9STRE/223-353                 ............s-KSSTTTSSDTSNIKKAVKAFNSAYDDFFTDSK.QT..ALKNSQF-DKLSDLENLLKKTK..G.......SSSYSKLKSKFDSLTKQITAIKAVNEKF..SS....DAIVDGK-K.VSASVKSD.A.N.FDDIks...atLNTGN..ASLDSLLQQVVS-d.................
A0A380KZA9_9STRE/219-345             .........sski----STSSSSSSSTASQEKAFTDLYNTFFTDDQ.HT..SLKNSSF-GELDKLKALLDKLS..G.......TAKYDTYKKQYDDLVKQITAIQSVNAQF..KT....AAITDGNLD.SNAQVKSD.A.K.FSDT.......-TTGN..NKLDQLLSSAISQ..................
Q8DVK9_STRMU/207-337                 ............r-TTKSTSTKKSTDFTAASKRFEKSYTAFFADAK.RT..KLKNNQF-ANLPKLEKHLKKLK..D.......SKYYDEAKKKYESLKRQISAINAVNGKF..KT....TAILNGD-K.KAAAVKDN.A.N.FDDIse...ksLNTGN..ATLDALLKSVIA-d.................
A0A4P5PD82_9ENTE/169-297             ............k-QAEAKEIELAKKENQQVKQVKSAIADFYTDKQ.QT..FLKPEALEKDTTDLKKLIEDHK..D.......HQAYTQLQSAYDRLVEKQKLTQSVNQLF..TA....PAIQGDALA.DSLQLKSD.Q.A.ILLT.......ANTAD..QSFNQLMNQAIT-t.................
A0A4D7CVK5_9ENTE/642-771             ..........kal---EQQRMEQIAANNKANEQAKLSLEKLYADSS.HS..LLKVGISMESIDEVAEQIAALS..D.......KSYKQELTNQLAKASQQLEEVATLNNLF..EA....PVLVDNKVQ.KDALVKVS.T.T.YKEL......iEKTET..DEYATLYNQAIT-l.................
A0A841C687_9LACT/382-509             ..........als---SASSSSSSLAASKKLINFNKLYDSFFTDAN.KT..ALKNSNF-DLLTNLKKDLDVFP.rS.......NLNYASLKAKYDDLSSNINAINTVNAIF..DK....AVIVDGKII.STATLTTG.A.T.IPSV.......-SSKN..VTINTVLKDAIK-l.................
A0A1E8GR04_9LACT/216-345             kkaamereeqalk----------VANIKKKENNFETLYDSFYTNDK.HT..ALKNENI-DKFNDIKDSLSKTK..D.......SEKYDEYKGQVDNLKKQIESLNVINSKF..NK....PVIVDGKLI.KDAHAKPN.V.D.FIVN.......-KSGL..TELDQTIDQAVAM..................
A8AVU7_STRGC/189-315                 ............q-ASKKTSSSSSSSENKALKKFNDLYDSFFTDKN.KL..ALKNSSF-ANLDQLKAALEALK..N.......DKEYTVAKAKYDSLVKQISAIQAVNSQF..ET....AAIKDGVLD.TNAKVKGD.A.T.FTET.......-KTGN..DNLDKLISSAISQ..................
A0A1T4K3M8_9ENTE/223-350             ............d-SQAKQRTLQMAKDKTALENLEKEIPSFYFDKE.QH..FIKSEKL-KDIASFVKKFNALK..G.......TKGFETVQPLIEQLKQKAKITQDVNLLF..TK....NAFENDKIV.KDLVLAKY.K.A.VTLT.......SDTKD..TAFDTVANQAID-e.................
A0A430AZY1_9ENTE/175-305             ...........ky--ESNAREKRAAQTEKAYKQAKIDFEKLYFDEN.KI..FLHSDVSKDKIDKASDKIETID..N.......KEFQEDLKEIESDVRERFEKQDGLNILF..DQ....PVLVGDTLD.DKALVKEN.I.SsVSLE......iSDKEQ..DAFDKKINEGIQ-l.................
E6LF79_ENTI1/265-393                 ..........qav---AQAEREQEAKEKAQLASIASEVTELFTDDQ.QQ..LLKDTTTATQISNLDNRLSLLK..K.......VAGYKDIKQVLADAQEKLTQVEALNEKF..TS....PILVNGEIQ.TDAHVKNV.D.T.ATFS.......KLTGN..STFEETYNKAVT-v.................
A0A380K5B9_9STRE/202-332             ............t-STSTSSSTSAKAAKEANSAFTKAYDAFFTDNT.QT..ALKNSQF-DQLSDLKTKLDALK..N.......TSYYKAAKGKYDSLEAQIKAIQVVNAKF..DS....ARVVDGS-Q.TDATVKSD.A.N.FDDLas...stLNTGN..STLDKLLQAAVT-d.................
S0RPN3_ENTAV/249-377                 ............k-EVEAQRIATVKKENKVLDTIEESIDSYYTDDQ.HT..FLVADKVNLNTGKIDEELSKYK..D.......HKRYDELKKEYDELSNKQKAEQSVNQLF..TS....PAINGNKLA.DKPLLKTA.E.P.VNLT.......VNTGD..KEFDTLMSQAIT-n.................
A0A1Q2D3A7_9ENTE/221-355             ...........yn---NHQKNIEQEQATQLIATAETAVKSLFLNSE.HV..FLKENMTKNDLTKAQTDLNKIK..N.......QSNYNDLNRLFETAEATFNRQTELNDLF..KE....PVLNGQTLSlDDAYVKNA.D.N.TALK.......QIDGSkvTAFDQLFNE----glseaiaq..........
V6Q3M2_9ENTE/126-256                 .........kyad----AKEAERLEKVEQAYQKTTLAFEKLYFDEQ.HI..FLNAGITEDKILRADKRIDAVD..N.......DAYQKELTKMSVDIHDRFKKQQSINQYY..EN....NYIVGNTLN.DQAILKEN.V.D.EILTr.....pVNSEK..DEFDKMINHAL--ee................
A0A2A5RZQ7_9LACT/293-419             ............a-ETAKQSSQQKSEEAKQLSSFNQKYAAFFMDDA.HT..KLKNGQF-SKLSELESELDKLS..A.......HPDYQSLKTKVAALKTEIKTIQDINNQF..NK....AVVTDGNLD.KTAEVKDG.V.T.LSYT.......-ATEN..DTLNNLLKAAVAQ..................
A0A5C5T7U7_9STRE/201-331             ............s-SSSTQSSTDTATAKADYNSFTELYGTFFADSE.KT..KLKNSEF-ANLPNLETALNKLK..G.......TSYYDKAKADYDKLSKSIAAVQAINSKF..ET....DAIVDGE-K.VATSLKAD.V.N.LDDLss...dvLNTGN..ASLDTLLQSVIS-e.................
R3W684_9ENTE/284-412                 ............k-ENDAQQVEETKKKATELESIQKSLDAFYTDDT.HE..FIRVEKVGGDLTKLSTQLDALK..D.......QKGYEKVSTTFTDVSNKVSMIQKTNELF..TE....PVISDNTLV.KNPLLKVD.K.K.IDLE.......PMKED..TAFAKLINEAIS-v.................
C9AAM6_ENTCA/272-399                 .............QQQETARETQLAQENRTLDQIENELNDFYTNDE.RV..FIKNDKTSEQLTAVTNQLAEFQ..D.......HERYDALSQEAATIADKLATLTEINSYF..SS....PAVVEDQL-.EEVSLKEA.A.A.VTMA.......-KREN.gDAFDELINQAIDM..................
T1ZEM9_STRIT/226-353                 ...........st-SQTSKYSTASSSENKDLKAFNSLYDSFFTDAN.KL..ALKNSSF-GNLDKLKAALEKLK..N.......TNEYNVAKAKYDSLVKQVEAVKNVNAQF..TS....VAITDGVLD.TKAKIKSD.A.K.FTDI.......-TTGN..TDLDKVLKAAIS-l.................
S0L6Q0_9ENTE/355-483                 .............QELERQAQAELVKKEANVASLMKDIQALSVSKE.EP..IVKASTTKSQLTEYQKQLTALK..G.......IKEEKEASQFVDTLITQYTLQEDLNKQF..NT....PVLVDGKVN.DQAYVLNT.Q.T.FLAV.......PIKDA..TAFDQAYNQAVT-l.................
A0A4R0QM86_9STRE/177-304             ............s-SSSTKTSSTDSAQKQAVAAFETRYKAFFTDAA.LT..KLKNSEF-DKLTELKALLDQLD.kD.......SEGYKLAKEKYDSLEKAIKATQAVNGQF..DK....PILVDGELD.TTATVKGD.A.K.LEPA.......-TTGI..GSVDAAVTSVIN-f.................
A0A139NGT6_9STRE/223-353             ............s-STTTSSSSETASAKKANTSFNQAYRAFFTDDS.QT..KLKNSQF-DQLPQLKKALDKLK..N.......TSYYTNAKKKYDSLNRQITAIRAVNALF..QS....DAINDGE-K.TGAKVKSD.A.N.FDSLss...dsLNTGN..AALDKLLQEVIA-d.................
#=GC seq_cons                        ............p...ptppspppsppppthpshppthssFaoDsp.ps..hLKssph.spLspLcppLccLc..s.......sptYsphcpch-sLppplpslpslNshF..pp....ssIssucLs.ssuplKss.s.s.hs.h........pTss..ssh-pLlspAls...................
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