GenomeNet

Database: Pfam
Entry: MetRS-N
LinkDB: MetRS-N
Original site: MetRS-N 
#=GF ID   MetRS-N
#=GF AC   PF09635.10
#=GF DE   MetRS-N binding domain
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   pdb_2hsn
#=GF GA   24.80 24.80;
#=GF TC   25.20 25.60;
#=GF NC   24.50 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16914447
#=GF RT   Structural basis of yeast aminoacyl-tRNA synthetase complex
#=GF RT   formation revealed by crystal structures of two binary
#=GF RT   sub-complexes. 
#=GF RA   Simader H, Hothorn M, Kohler C, Basquin J, Simos G, Suck D; 
#=GF RL   Nucleic Acids Res. 2006;34:3968-3979.
#=GF DR   INTERPRO; IPR018285;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The MetRS-N domain binds an Arc1-P domain in a tetrameric
#=GF CC   complex resembling a classical GST homo-dimer. Domain-swapping
#=GF CC   between symmetrically related MetRS-N and Arc1p-N domains
#=GF CC   generates a 2:2 tetramer held together by van der Waals forces.
#=GF CC   This domain is necessary for formation of the aminoacyl-tRNA
#=GF CC   synthetase complex necessary for tRNA nuclear export and
#=GF CC   shuttling as part of the translational apparatus. The domain is
#=GF CC   associated with Pfam:PF09334.
#=GF SQ   52
#=GS C5MJ30_CANTT/8-83        AC C5MJ30.1
#=GS A0A1E3QSB4_9ASCO/9-114   AC A0A1E3QSB4.1
#=GS G0VGT4_NAUCC/12-126      AC G0VGT4.1
#=GS G3B4G5_CANTC/9-122       AC G3B4G5.1
#=GS E7KNW8_YEASL/11-132      AC E7KNW8.1
#=GS H0GGZ2_SACCK/11-132      AC H0GGZ2.1
#=GS Q74Z74_ASHGO/11-130      AC Q74Z74.1
#=GS G8YT24_PICSO/11-122      AC G8YT24.1
#=GS I2H267_TETBL/11-131      AC I2H267.1
#=GS A0A1D8PP21_CANAL/9-120   AC A0A1D8PP21.1
#=GS G8C088_TETPH/10-132      AC G8C088.1
#=GS M3IJN0_CANMX/9-121       AC M3IJN0.1
#=GS A7TNV8_VANPO/11-132      AC A7TNV8.1
#=GS H2AQ02_KAZAF/11-125      AC H2AQ02.1
#=GS A0A1G4IS02_9SACH/11-130  AC A0A1G4IS02.1
#=GS J7S704_KAZNA/11-130      AC J7S704.1
#=GS A0A2H0ZJM0_CANAR/9-130   AC A0A2H0ZJM0.1
#=GS A0A0F4X9E1_HANUV/13-119  AC A0A0F4X9E1.1
#=GS A0A1G4MDX3_LACFM/11-132  AC A0A1G4MDX3.1
#=GS E7NI85_YEASO/11-132      AC E7NI85.1
#=GS A0A1E5S0U2_HANUV/13-119  AC A0A1E5S0U2.1
#=GS A0A0C7N871_9SACH/11-132  AC A0A0C7N871.1
#=GS H0GVF6_SACCK/11-132      AC H0GVF6.1
#=GS A0A1E5RWX7_9ASCO/13-119  AC A0A1E5RWX7.1
#=GS G8BNZ1_TETPH/11-80       AC G8BNZ1.1
#=GS A0A1G4K4D1_9SACH/11-131  AC A0A1G4K4D1.1
#=GS W0T3X2_KLUMD/11-132      AC W0T3X2.1
#=GS A0A0H5CB96_CYBJA/8-111   AC A0A0H5CB96.1
#=GS A0A1E4TTJ7_PACTA/9-127   AC A0A1E4TTJ7.1
#=GS A0A1E4S624_CYBJA/8-111   AC A0A1E4S624.1
#=GS C4R0E2_KOMPG/11-95       AC C4R0E2.1
#=GS SYMC_YEAST/11-132        AC P00958.4
#=GS SYMC_YEAST/11-132        DR PDB; 2HSN A; 13-134;
#=GS A5DIE2_PICGU/9-123       AC A5DIE2.2
#=GS A0A1L0BBA1_9ASCO/8-120   AC A0A1L0BBA1.1
#=GS G8YUH6_PICSO/11-122      AC G8YUH6.1
#=GS G0W8A8_NAUDC/11-129      AC G0W8A8.1
#=GS A0A1G4J9P0_9SACH/11-132  AC A0A1G4J9P0.1
#=GS G8JSR6_ERECY/11-132      AC G8JSR6.1
#=GS A0A1E4RLH5_9ASCO/9-124   AC A0A1E4RLH5.1
#=GS J8Q7R6_SACAR/11-132      AC J8Q7R6.1
#=GS C5DD77_LACTC/11-132      AC C5DD77.1
#=GS B5RUW5_DEBHA/9-123       AC B5RUW5.1
#=GS J5PNA7_SACK1/11-132      AC J5PNA7.1
#=GS Q6CXB8_KLULA/38-158      AC Q6CXB8.1
#=GS A0A1V2L2U5_CYBFA/8-89    AC A0A1V2L2U5.1
#=GS A0A1E5RHT1_9ASCO/9-125   AC A0A1E5RHT1.1
#=GS G8ZYF8_TORDC/11-131      AC G8ZYF8.1
#=GS G3ASH9_SPAPN/10-121      AC G3ASH9.1
#=GS A0A1E3P8T0_WICAO/8-89    AC A0A1E3P8T0.1
#=GS Q6FTV8_CANGA/11-130      AC Q6FTV8.1
#=GS C5DVL1_ZYGRC/11-131      AC C5DVL1.1
#=GS A0A1X7R9S3_9SACH/11-134  AC A0A1X7R9S3.1
C5MJ30_CANTT/8-83                   ...tkg---SSLLALSNNLKLAIALSSYQ.PKLSLTLNETESQ...LSL..kDKKSGFELIEPNAIVKYLANDFTNDKA------------------.---.------..---------.--.-----------------ikfeeqvvy....................................................
A0A1E3QSB4_9ASCO/9-114              ...tgs----TSLTLVANLKVAIAASAFQ.PKLEVAANETDTV...TLL...DKKSGFTLIEANAIVKYLSNDFSASTVYE----ETTLHA------.---.------..---------.--.-----------------atkqssltaelltvefskaeltaeqiiyfaaay............................
G0VGT4_NAUCC/12-126                 ......KDHSHQVTLANNLKVALAIEYAT.KDLKLTIDEETDE...TLL...AVSDSFHLVDANAIVRYALNDFNDQDSGEYE-----LQSTLYENE.APA.D-IDNI..VTNTISKYL.TD.IKEPVSATKLITLANAF.............................................................
G3B4G5_CANTC/9-122                  ...dkg---NSTLSLVNNLKVTVAAKAAD.GNLKVNSEDDSNL...KLL...NKATGFELTEPNAIVKYLINDFDSAS-------------------.---.------..---------.--.-----------------ilsieetavysahksgkkeevisfiksesspftkaeltasqiilfssvy............
E7KNW8_YEASL/11-132                 ......KKHPAHLQLANNLKIALALEYAS.KNLKPEVDNDNAA...MEL..rNTKEPFLLFDANAILRYVMDDFEGQTSDKYQFALASLQNLLYHKE.LPQ.QHVEVL..TNKAIENYL.VE.LKEPLTTTDLILFANVY.............................................................
H0GGZ2_SACCK/11-132                 ......KKHPAHLQLANNLKIALALEYAS.KNLKPEVDNDNAA...MEL..rNTKEPFLLFDANAILRYVMDDFEGQTSDKYQFALASLQNLLYHKE.LPQ.QHVEVL..TNKAIENYL.VE.LKEPLTTTDLILFANVY.............................................................
Q74Z74_ASHGO/11-130                 ......KDHSYGFQLANNIKLALAQVLAP.AGCTLKVCENEG-...PQL...TSGSGFRLFDANAILRFVLNDYEASGSDECQYAQASLEHMLHRSE.MVP.DYVTTA..ANKSLEHYL.VS.MEEPLSATRLITFANTY.............................................................
G8YT24_PICSO/11-122                 ....gt----SLLALSNNLKVAIATKLYK.PDLDFSNKEDESG...LKL..rNNADGFELVEANSIVKYLSNDFS--TSEDLAFEETVLFHALKSG-.-KK.DEI---..-EGALKSRS.FS.FGKDVSASLIILFATVY.............................................................
I2H267_TETBL/11-131                 ......KNHSQGLTYANNLKLALAQQFAS.KGTKIEIDTEARQ...LQL...TKGDNLRLVSADAILRYIMNDFSGQDSDEYDFSLASLESLLYHTS.PPS.NHIDQC..VEKALDNYL.TS.LSEPLTATRLITYANA-s............................................................
A0A1D8PP21_CANAL/9-120              ..kgnt-----LLALTNNLKLSIALAAFE.PKVELTLNEVESN...LSL..kDKKSGFELIEPNAIVKYLAKDFTTTEAIKF---------------.---.------..---------.--.-----------------eeqvlysaiksnkkdelakitdlpkfakeeltpsqiivfasly..................
G8C088_TETPH/10-132                 ....nk-HDTNLLKLANNLKLLLGVEYNN.RDFEIEMDEDCQI...PRL...-MSDTVCLYEPNAILRYLINDYHGIEDEEYERFVKKFDNLCHKEF.GNK.EDMQSElqMEVAADKYL.QN.LENNVTANDLILFADVY.............................................................
M3IJN0_CANMX/9-121                  ..kggs-----LLSLANNLKLAIAISVFH.PELKLVLDESDSK...LVL..kDKKSGFELIEANAIVKYLANDFT--SSDAIDFEESVLYPAV----.--K.SNKKDE..VSKVLSQLP.TF.GKTELTPSQIILFASVY.............................................................
A7TNV8_VANPO/11-132                 ......KKHSRFLATANNLKLALALEYTT.GDLKIAVDDDSTG...PLL..mGPNGSFHLVDANAILRYAMDDFVGSQSKEYLDSLKKIESLFYGVD.TLPiDQIDSL..TA-TLASAS.DF.VAEPVDATKLIIFANAF.............................................................
H2AQ02_KAZAF/11-125                 ......KTHSHELTLANNLKIALAIQFAT.KDFKFKINEDEST...PKL...SIGDSFNLIDTNSILRYAMNDFEGQDSEQYQFALCTLQPQLYKST.DSA.EAVTKA..A-----TFL.QD.LSTP-SASQLIILANSY.............................................................
A0A1G4IS02_9SACH/11-130             ...kcs---NDALKLANNLKLAFAKKLAK.DEII--VDDDANS...VEL..tVAGSDFRLFNTNAILRYVLGDFDGLDSPETHYAVSSLEAVLYHPS.APR.EHVDET..VVKALENYL.TT.LNEPLTATRLITFSNAY.............................................................
J7S704_KAZNA/11-130                 ......KNHSAKLQLANNLKLALAVEFAT.KDLKIKINDTVDS...PSL...-TTDKVHLFDADAILRYAMDQFSGAFTSESFDSLSKLEPALYKEE.LTT.-HDKEH..AVHALKNYL.VSnLKDTDSATKLITFANV-a............................................................
A0A2H0ZJM0_CANAR/9-130              .kgkgf------LAQANNVKVAVALALAT.PNVEISRSDDSS-...LQL..kEVKSAFELVEPNAIVKYITGDFSN---------------------.---.------..---------.--.-----------------gvnisteetdvyqalksgkkelavealkkletpqdtkessaniivfgavypfltdiqets.
A0A0F4X9E1_HANUV/13-119             ...ikn----EKVLRAYNLKVILASKLIS.KS-EVSTDASFLT...PGL..lNSTTGFSLFNANSILKYAFKNYDVS--------------------.---.------..---------.--.-----------------veisdlekalisgtdvseeqltnllekkegenafksvsnwilia.................
A0A1G4MDX3_LACFM/11-132             ......KKHPQAVQLANNIKLALAQGLAS.KDYKLTISEEGNG...LQL..lDTVTGYRLFNSNAILRYLLNDFEGIEKEESHFALSTLEALLYHSD.VQK.QHVEEA..VSKSLENYL.LR.LDEPLSALRLITFVNTY.............................................................
E7NI85_YEASO/11-132                 ......KKHPAHLQLANNLKIALALEYAS.KNLKPEVDNDNAA...MEL..rNTKEPFLLFDANAILRYVMDDFEGQTSDKYQFALASLQNLLYHKE.LPQ.QHVEVL..TNKAIENYL.VE.LKEPLTATDLILFANVY.............................................................
A0A1E5S0U2_HANUV/13-119             ...ikn----EKVLRAYNLKVILASKLIS.KS-EVSTDASFLT...PGL..lNSTTGFSLFNANSILKYAFKNYDVS--------------------.---.------..---------.--.-----------------veisdlekalisgtdvseeqltnllekkegenafksvsnwilia.................
A0A0C7N871_9SACH/11-132             ......KKSNSGLKLANNLKIALAQNLAD.ANSKLTIDTESNE...LRL..tVAGSEFSLFNANAILRYVLADFKGLESPESHFAVSSLEALLYHPN.AHK.EHIDET..VNKALENYL.LD.FTEPLGATKLITFANAY.............................................................
H0GVF6_SACCK/11-132                 ......KKHPAHLQLANNLKIALALGLAN.KNLKLEVNDDNAA...MEL..cSTKEAFTLFDANAILRYIMDDFEDQSSDKYQFALASLQNLLYHKE.LPG.QHVEVL..TNKAFENYL.AE.LKEPLTATDLILFANV-c............................................................
A0A1E5RWX7_9ASCO/13-119             ....ik---DEKVLRAYNLKVILASKLIT.-KSEVSTDASFLT...PGL..lDTKTGFSLFNANSILKYAFKEFDVS--------------------.---.------..---------.--.-----------------aqiddlekslisgaevseqelxqlltkeesgnvsksvsnwivla.................
G8BNZ1_TETPH/11-80                  ......KEHPQELLIANNLKLTIALEFKT.KDLKLSVNEDLKT...PSL...SINDQFRLFNTDAILRYALNDFEGLN-------------------.---.------..---------.--.-----------------vevss........................................................
A0A1G4K4D1_9SACH/11-131             ......KTHGYALQLANNIKIALALDLAK.DGVSFKLNEETDE...PRA..eDVKSNFRLFNANAILRYALNDFEGLQDPESHYALSSLEALLYHDAtAPK.EHLEEN..VSKSLENYV.-S.L-DKVAATNLITFANTY.............................................................
W0T3X2_KLUMD/11-132                 ......KLHTATLQLANNIKLAYALLSAP.ASLKLEENSEVSV...SQL..iVGSSGFRLFDANAILRYVLNDFESEESDEYSFAVSSLEALASHKD.QIK.EHVTES..VKKSIETYL.TS.VEEPLSATRIVTFANSY.............................................................
A0A0H5CB96_CYBJA/8-111              dkskgl------VALSNNLKLAIAS----.KVYSVKIEQEEGK...FGL..eDTEKGFQLIEPNAIVKYLAREFA--QSQEIEYEESTLFPLLSKNQ.GSK.------..---------.--.-----------------lslsfamthitpsaiilfatay.......................................
A0A1E4TTJ7_PACTA/9-127              .kggsi------LSVVNNLKIAVASSIFL.PSLKLKFDEDQEK...LAL..kDKKSEFRLIEPNAIVKYLG--------------------------.---.------..---------.--.-----------------sisnnntksffqksslieyeeseiysslvnnnfeninfskinidkvdsksveqiilfssly
A0A1E4S624_CYBJA/8-111              dkskgl------VALSNNLKLAIAS----.KVYSVKIEQEEGK...FGL..eDTEKGFQLIEPNAIVKYLAREFA--QSQEIEYEESTLFPLLSKNQ.GSK.------..---------.--.-----------------lslsfamthitpsaiilfatay.......................................
C4R0E2_KOMPG/11-95                  ...sgl------LDLSDNLKLSIATSLFS.KACVLQDKDVTET...VLL...KTKSGFELFEPNAIVRYL---------------------------.---.------..---------.--.-----------------assrigldafkrsnlshfeevvlynvlksgk..............................
SYMC_YEAST/11-132                   ......KKHPAHLQLANNLKIALALEYAS.KNLKPEVDNDNAA...MEL..rNTKEPFLLFDANAILRYVMDDFEGQTSDKYQFALASLQNLLYHKE.LPQ.QHVEVL..TNKAIENYL.VE.LKEPLTTTDLILFANVY.............................................................
#=GR SYMC_YEAST/11-132        SS    ......SS--HHHHHHHHHHHHHHHHH--.STT--EE-SS--S...--E..EE-S--S----HHHHHHHHTT--TTTTSHHHHHHHHHTTTGGGSSS.--H.HHHHHH..HHHHHHHT-.S-.--SS--HHHHHHHHHHH.............................................................
A5DIE2_PICGU/9-123                  drgsdl------LALASNLKVCIGALVFQ.GGIQVELGEDESH...TGL..kDSKTGFRLLESNAIVKYLAKDFKRTEA--IEFEETKL--------.---.------..---------.--.-----------------yqalksnqkeqimalsdllpdfadnqeitaekviifsaly.....................
A0A1L0BBA1_9ASCO/8-120              ...dkg---KTNLALVNNLKVSVAAAKFQ.PKLEITVSDDSG-...LLL..kDKKSAFELVEANAIVKYLSGDFAASD-------LFSVDEVAVYDA.LKS.GSSQKA..V-EALDSVT.VP.SNNDFSAANIVLFGAAY.............................................................
G8YUH6_PICSO/11-122                 ....gt----SLLALSNNLKVAIATKLYK.PDLDFQNKEDESG...LKL..rNNADGFELLEANSIVKYLSNDFS--TSEDLEFEETVLFSAL----.---.------..---------.--.-----------------ksgkkdeiegalksrnfsfgkdvsasliilfasvy..........................
G0W8A8_NAUDC/11-129                 ......KDHSHAISFANNLKIALAIEYAT.KDLKLTINDDSNI...AQL...VVSDSYQLFNPNAILRYALNDFTDQESEANQFAVTIVEKALISSE.TSS.---KEV..VTKTLEQYLpYP.IEEPVSATKLILLAD--il...........................................................
A0A1G4J9P0_9SACH/11-132             .....t-GQNAALQLSNNLKLAFAQELAD.AKVKLTVNTDATT...PEL..tVSGSEFRLFNANAILRYVLDDFEGVHSQETHYAVSSLEAMLYHPN.APQ.VHIQET..VTKALENYL.TD.LQETPCATRLITFANVY.............................................................
G8JSR6_ERECY/11-132                 .....k-TQLSGLQLATNIKLALALQLGDiSASKIAVNDEAVG...PQL...FGPPLFRLFDSNAILRYVMDDFEGLDSEEGLFALSSVEAVLHHKS.IQK.EHVESI..ASKSLDSYL.LS.LQEPLSATKLITFANTY.............................................................
A0A1E4RLH5_9ASCO/9-124              .dkgnn-----LLSLVNNLKLSIASQVYQ.PKLAVTISEEDIS...VEL..kDKKTGFQLNEANAIVKYLAGDFTSHPA--INFEE--LLVYKALKS.NKK.ENVIKV..ATEEVKSFF.GK.--AEMKAAQIILFSA--ly...........................................................
J8Q7R6_SACAR/11-132                 ......KQHPTHLQLANNLKIALALEFTG.EKLKLEVDDDSTT...MEL..hSAKEPFTLFDANAILRYVMDDFEDQSSDKYQFALASLQNLLYHKE.LPK.QHVEVL..TIKAIENYL.TE.LREPLTATDLILFANIY.............................................................
C5DD77_LACTC/11-132                 ......KDHSYALQLANNIKLALAQELAG.KEIKISVNDESVK...PEL..tVASTDFRLFNTNAILRYVLNDFEGLESSETHFAVSSLEAMLYHPS.APQ.EHVKEN..VSKALENYL.QE.LREPFCATNLITFANAY.............................................................
B5RUW5_DEBHA/9-123                  ...ekg---SSLLTLASNLKLSLVSAIYQ.PKLSVSLSENESS...LSL..iDKKSGFELSEPNAIVKYLANDFNKDK--LLEFEETSLYKAA--KS.NKK.DAIVQA..INES---SI.KL.EKAETSTSQIILFAAVY.............................................................
J5PNA7_SACK1/11-132                 ......KKHPAHLQLANNLKIALALGLAN.KNLKLEVNDDNAA...MEL..cSTKEAFTLFDANAILRYIMDDFEDQSSDKYQFALASLQNLLYHKE.LPG.QHVEVL..TNKAFENYL.AE.LKEPLTATDLILFANVY.............................................................
Q6CXB8_KLULA/38-158                 ......KGHTSALQLANNIKLAYAL-LSS.GNLKLEENKDVLI...PQL..vIDSTGFRLFDANAILRYVLNDFEEEESNEYNFAVSSLEAFASHKD.PIK.EHLAEA..VQKSLDNYL.TS.VEEPLSATRIVIFANTY.............................................................
A0A1V2L2U5_CYBFA/8-89               ..dksk----GAVALSNNLKLAIAAEAY-.---KQKLDTDADK...PSL..lLKSNGVEITEANAIVKFLAGDFTTSS-------------------.---.------..---------.--.-----------------diefdedvlypalkktdasv.........................................
A0A1E5RHT1_9ASCO/9-125              .....r-NHSLALQKANNLKIALSLI---.KNPKLSVDEEAAKntgSQL..vDEKTGFALFNTNAILQYVFQDFS----IKHPFAITNLEPILQTTK.ENN.QHVEEL..VKKTIENYL.S-.SDFDVNASNLIMFANAY.............................................................
G8ZYF8_TORDC/11-131                 ......KGRQQALSLSNNLKITLALEYAS.KDFKIAVNEELEG...PQL...INGDNLRLIDTDAILRYILNDFEGQRSDEYHYALSSLESLFQKND.IPE.QHVEAC..VSKSLDNYL.LS.LEEPLSATRLITFANTY.............................................................
G3ASH9_SPAPN/10-121                 ...kgs----SLLTLSTNLKLCIAT--SA.FQPKLSVSNDTPS...DALl.kDKKSDFALHEVNAVVKYLANDFSTN--EAIQFEETQLYKAL--KS.NKK.EKLTSA..VSGSIT---.-F.TKAELTPAQIILFASVY.............................................................
A0A1E3P8T0_WICAO/8-89               ...dkg---KSTLALANNIKLAIAA--AS.FGLKFSPEPEQPS...LLL...KNDKGFELSEPNAIVKYLAKDFTQTR-------------------.---.------..---------.--.-----------------eiefeedllskaifsndvt..........................................
Q6FTV8_CANGA/11-130                 ......KGRDAKVVLANNLKIALAIELA-.KGLKLSINEDRSE...PLL...-TAGELVLRDANAILRYALDDFEGIHSEQYHYALSSVEAYLYHQQ.SSE.EHATEL..VNKMIDNYLkLD.KDSKLDAVTLISFANAY.............................................................
C5DVL1_ZYGRC/11-131                 ......KGHAQAVTFANNFKIALGLEYAA.KGTKTTVNEDNVG...PAL...IQGESFRLFDSNAILRYLLNDFAPQQVDEYEYALSSLEHLLHQKQ.VPK.EHADEC..VDKALNNYL.TS.LEEPLSATRLISFVNAY.............................................................
A0A1X7R9S3_9SACH/11-134             ..ngfs----SYFNYSTNLKIALALEYAT.KDLKIQVNDDNKT...VQFvnqVQGQEFTLFNANAILSYAMNDFAGQDSEEYHYAESSLESFFRQQE.IPQ.EHATVC..VQKTLDNYL.TS.LEEPMTSLKLITFVNAF.............................................................
#=GC SS_cons                        ......SS--HHHHHHHHHHHHHHHHH--.STT--EE-SS--S...--E..EE-S--S----HHHHHHHHTT--TTTTSHHHHHHHHHTTTGGGSSS.--H.HHHHHH..HHHHHHHT-.S-.--SS--HHHHHHHHHHH.............................................................
#=GC seq_cons                       ..........ttLpLANNLKlAlAhphss.tslKlpls--sst....pL..hsspsuFpLh-uNAIL+YlhsDFpstpu.chpat.ssL.shh.t.p...t.ttht....s.tshpph......tt.hsssplIhauss..............................................................
//
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