GenomeNet

Database: Pfam
Entry: Myc-LZ
LinkDB: Myc-LZ
Original site: Myc-LZ 
#=GF ID   Myc-LZ
#=GF AC   PF02344.15
#=GF DE   Myc leucine zipper domain
#=GF AU   Bashton M;0000-0002-6847-1525
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_829 (release 5.2)
#=GF GA   21.40 21.40;
#=GF TC   21.40 21.40;
#=GF NC   21.30 21.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10679391
#=GF RT   Action of Myc in vivo - proliferation and apoptosis. 
#=GF RA   Pelengaris S, Rudolph B, Littlewood T; 
#=GF RL   Curr Opin Genet Dev 2000;10:100-105.
#=GF RN   [2]
#=GF RM   9680483
#=GF RT   Insights into the mechanism of heterodimerization from the
#=GF RT   1H-NMR solution structure of the c-Myc-Max heterodimeric leucine
#=GF RT   zipper. 
#=GF RA   Lavigne P, Crump MP, Gagne SM, Hodges RS, Kay CM, Sykes BD; 
#=GF RL   J Mol Biol 1998;281:165-181.
#=GF DR   INTERPRO; IPR003327;
#=GF DR   SCOP; 1a93; fa;
#=GF DR   SCOP; 2a93; fa;
#=GF DR   PROSITE; PDOC00038;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of the leucine zipper dimerisation domain
#=GF CC   found in both cellular c-Myc proto-oncogenes and viral v-Myc
#=GF CC   oncogenes.  Dimerisation via the leucine zipper motif with other
#=GF CC   basic helix-loop-helix-leucine zipper (b/HLH/lz) proteins such
#=GF CC   as  Max Swiss:P25912 is required for efficient DNA binding.  The
#=GF CC   Myc-Max dimer is a transactivating complex activating expression
#=GF CC   of growth related genes promoting cell proliferation. The
#=GF CC   dimerisation is facilitated via interdigitating leucine residues
#=GF CC    every 7th position of the alpha helix.  Like charge repulsion
#=GF CC   of  adjacent residues in this region perturbs the formation of
#=GF CC   homodimers  with heterodimers being promoted by opposing charge
#=GF CC   attractions.
#=GF SQ   122
#=GS A0A2I4C604_9TELE/396-426  AC A0A2I4C604.1
#=GS MYC_CALJA/407-437         AC P49032.1
#=GS F1RRR8_PIG/421-451        AC F1RRR8.4
#=GS H3BC93_LATCH/362-390      AC H3BC93.1
#=GS V8NRI7_OPHHA/103-133      AC V8NRI7.1
#=GS A0A1S3A6X8_ERIEU/406-435  AC A0A1S3A6X8.1
#=GS I3KLY4_ORENI/53-84        AC I3KLY4.1
#=GS W5U5R6_ICTPU/363-392      AC W5U5R6.1
#=GS H0ZQJ1_TAEGU/399-429      AC H0ZQJ1.1
#=GS M3ZII1_XIPMA/401-431      AC M3ZII1.1
#=GS I3K8Y8_ORENI/390-418      AC I3K8Y8.1
#=GS Q6UG91_SSV2/7-30          AC Q6UG91.1
#=GS F7IB97_CALJA/388-418      AC F7IB97.1
#=GS MYC_FELCA/408-438         AC P68271.1
#=GS H0WRX5_OTOGA/421-451      AC H0WRX5.1
#=GS I3M553_ICTTR/422-452      AC I3M553.2
#=GS A0A0D9RCK4_CHLSB/408-438  AC A0A0D9RCK4.1
#=GS M7BQH3_CHEMY/271-301      AC M7BQH3.1
#=GS F1PW15_CANLF/408-438      AC F1PW15.1
#=GS MYC_PANTR/408-438         AC P23583.1
#=GS W5MZP0_LEPOC/368-397      AC W5MZP0.1
#=GS H3DIC7_TETNG/386-416      AC H3DIC7.1
#=GS J9JU58_ACYPI/337-364      AC J9JU58.2
#=GS A0A286XIG5_CAVPO/407-437  AC A0A286XIG5.1
#=GS A0A1V4KVF0_PATFA/401-431  AC A0A1V4KVF0.1
#=GS A0A1U7RVT0_ALLSI/207-237  AC A0A1U7RVT0.1
#=GS F6X065_MONDO/442-472      AC F6X065.2
#=GS A0A0P7V0S8_9TELE/160-188  AC A0A0P7V0S8.1
#=GS S9X162_CAMFR/261-291      AC S9X162.1
#=GS Q9DFB9_ICTPU/359-389      AC Q9DFB9.1
#=GS G1NRT5_MELGA/159-189      AC G1NRT5.1
#=GS A0A1S3NCS6_SALSA/410-440  AC A0A1S3NCS6.1
#=GS MYC_SHEEP/408-438         AC Q28566.1
#=GS G7PCT8_MACFA/408-438      AC G7PCT8.1
#=GS MYC_MOUSE/408-438         AC P01108.1
#=GS A0A1I7Q473_MACMU/423-453  AC A0A1I7Q473.1
#=GS F7FXT9_ORNAN/151-181      AC F7FXT9.1
#=GS W5PDV5_SHEEP/392-422      AC W5PDV5.1
#=GS K7FM32_PELSI/293-323      AC K7FM32.1
#=GS MYC_PIG/408-438           AC Q29031.1
#=GS MYC_CHICK/385-415         AC P01109.1
#=GS L5K5M7_PTEAL/409-439      AC L5K5M7.1
#=GS A0A1S3FVS9_DIPOR/401-431  AC A0A1S3FVS9.1
#=GS G3NKK9_GASAC/368-398      AC G3NKK9.1
#=GS D8LS55_ECTSI/20-48        AC D8LS55.1
#=GS G3UBM1_LOXAF/410-439      AC G3UBM1.1
#=GS F6PFR6_MONDO/117-144      AC F6PFR6.2
#=GS L9JL37_TUPCH/408-438      AC L9JL37.1
#=GS F6YAJ2_HORSE/408-437      AC F6YAJ2.1
#=GS M3YHU3_MUSPF/56-85        AC M3YHU3.1
#=GS H0YBT0_HUMAN/422-452      AC H0YBT0.1
#=GS U3JIP7_FICAL/405-435      AC U3JIP7.1
#=GS MYC_CANLF/408-438         AC Q28350.1
#=GS Q6NRN4_XENLA/390-420      AC Q6NRN4.1
#=GS A0A1D5Q496_MACMU/424-454  AC A0A1D5Q496.1
#=GS A0A0P7V442_9TELE/358-385  AC A0A0P7V442.1
#=GS W5K5K0_ASTMX/362-392      AC W5K5K0.1
#=GS H2TBR0_TAKRU/385-415      AC H2TBR0.1
#=GS G1T737_RABIT/409-439      AC G1T737.1
#=GS G3SNI5_LOXAF/411-440      AC G3SNI5.1
#=GS MYCA_DANRE/379-408        AC P52160.2
#=GS H0ZQJ0_TAEGU/401-431      AC H0ZQJ0.1
#=GS M3WHW1_FELCA/69-98        AC M3WHW1.2
#=GS F1RC36_DANRE/380-409      AC F1RC36.1
#=GS A0A151P7W6_ALLMI/138-168  AC A0A151P7W6.1
#=GS MYC_RAT/408-438           AC P09416.1
#=GS A0A091FZ86_9AVES/222-252  AC A0A091FZ86.1
#=GS L5M1M2_MYODS/408-438      AC L5M1M2.1
#=GS W5MZP7_LEPOC/368-397      AC W5MZP7.1
#=GS A0A1U7TIM8_TARSY/311-341  AC A0A1U7TIM8.1
#=GS H2PR71_PONAB/422-452      AC H2PR71.2
#=GS G9KC04_MUSPF/422-452      AC G9KC04.1
#=GS G1R0L9_NOMLE/423-453      AC G1R0L9.1
#=GS MYCB_DANRE/367-396        AC Q7ZVS9.1
#=GS F8WFG7_RAT/408-438        AC F8WFG7.2
#=GS A0A1D5R6Y1_MACMU/423-453  AC A0A1D5R6Y1.1
#=GS H0ZQJ2_TAEGU/387-415      AC H0ZQJ2.1
#=GS A0A096N777_PAPAN/408-438  AC A0A096N777.1
#=GS A0A286XSY1_CAVPO/106-135  AC A0A286XSY1.1
#=GS A0A2I3SFA1_PANTR/423-453  AC A0A2I3SFA1.1
#=GS A0A0Q3Q8U6_AMAAE/385-415  AC A0A0Q3Q8U6.1
#=GS A0A1L8FTT4_XENLA/161-189  AC A0A1L8FTT4.1
#=GS I3JFX0_ORENI/402-432      AC I3JFX0.1
#=GS A0A087WVR4_HUMAN/423-453  AC A0A087WVR4.1
#=GS F8WID3_MOUSE/423-453      AC F8WID3.1
#=GS F7I481_CALJA/422-452      AC F7I481.1
#=GS G5B9M9_HETGA/361-391      AC G5B9M9.1
#=GS A0A1S3LUE5_SALSA/369-399  AC A0A1S3LUE5.1
#=GS H3BC94_LATCH/382-410      AC H3BC94.1
#=GS S7QEW7_MYOBR/408-438      AC S7QEW7.1
#=GS G1KK08_ANOCA/412-442      AC G1KK08.2
#=GS A0A2K5MUW0_CERAT/423-453  AC A0A2K5MUW0.1
#=GS MYC_BOVIN/408-438         AC Q2HJ27.1
#=GS A0A2K5JM08_COLAP/423-453  AC A0A2K5JM08.1
#=GS A0A087WSQ0_MOUSE/422-452  AC A0A087WSQ0.1
#=GS A0A2I2UI75_FELCA/508-538  AC A0A2I2UI75.1
#=GS G1M831_AILME/421-451      AC G1M831.1
#=GS A0A093GH59_DRYPU/246-276  AC A0A093GH59.1
#=GS G1QCG9_MYOLU/409-439      AC G1QCG9.1
#=GS A0A1U7QQI6_MESAU/409-439  AC A0A1U7QQI6.1
#=GS W5KXP7_ASTMX/361-390      AC W5KXP7.1
#=GS H3BYR3_TETNG/359-389      AC H3BYR3.1
#=GS G1M6Z5_AILME/53-82        AC G1M6Z5.1
#=GS A0A087WUS5_HUMAN/423-453  AC A0A087WUS5.1
#=GS G3RS08_GORGO/423-453      AC G3RS08.1
#=GS A0A087Y5Y0_POEFO/402-432  AC A0A087Y5Y0.2
#=GS A0A099ZEV6_TINGU/216-246  AC A0A099ZEV6.1
#=GS H2QWQ2_PANTR/408-438      AC H2QWQ2.2
#=GS A0A2K5MVB9_CERAT/408-438  AC A0A2K5MVB9.1
#=GS H0W5I8_CAVPO/96-125       AC H0W5I8.2
#=GS B2RSN1_MOUSE/423-453      AC B2RSN1.1
#=GS Q0VCC9_BOVIN/106-135      AC Q0VCC9.1
#=GS U3J2T2_ANAPL/169-199      AC U3J2T2.1
#=GS F1QDI6_DANRE/331-359      AC F1QDI6.1
#=GS Q6P1T1_XENTR/387-415      AC Q6P1T1.1
#=GS MYC_MACMU/408-438         AC B8XIA5.1
#=GS G3I0K0_CRIGR/42-71        AC G3I0K0.1
#=GS MYC_HUMAN/408-438         AC P01106.1
#=GS MYC_HUMAN/408-438         DR PDB; 1NKP D; 555-581;
#=GS MYC_HUMAN/408-438         DR PDB; 5I50 B; 61-91;
#=GS MYC_HUMAN/408-438         DR PDB; 5I50 A; 61-91;
#=GS MYC_HUMAN/408-438         DR PDB; 5I4Z B; 61-91;
#=GS MYC_HUMAN/408-438         DR PDB; 1NKP A; 955-981;
#=GS MYC_HUMAN/408-438         DR PDB; 2OR9 P; 1-10;
#=GS MYC_HUMAN/408-438         DR PDB; 1A93 A; 8-34;
#=GS MYC_HUMAN/408-438         DR PDB; 5I4Z A; 61-91;
#=GS MYC_HUMAN/408-438         DR PDB; 2A93 A; 8-34;
#=GS F6PX41_MOUSE/422-452      AC F6PX41.1
#=GS A0A087Y5W6_POEFO/401-431  AC A0A087Y5W6.2
#=GS A0A1S3QA70_SALSA/367-397  AC A0A1S3QA70.1
#=GS H2TBQ9_TAKRU/385-415      AC H2TBQ9.1
A0A2I4C604_9TELE/396-426             ....SDEQRLVSLKEQLRRRSELLKQRLAQLQGC-r...
MYC_CALJA/407-437                    ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
F1RRR8_PIG/421-451                   ....AEEQKLVSEKDVLRKRREQLKLKLEQLRNSC....
H3BC93_LATCH/362-390                 ....AEEQRLTVEKEQLRRKREQLKHKLAQLQS--....
V8NRI7_OPHHA/103-133                 ....SEEHRLLAEKEHLRKRHEQLKNKLQQLRNSC....
A0A1S3A6X8_ERIEU/406-435             ...t-EEQKLLSEKDLLRKRREHLKHRLEQLRN--c...
I3KLY4_ORENI/53-84                   eeqd---RKALNVKEQLQREHRYLKRRLEQLSVS-g...
W5U5R6_ICTPU/363-392                 ...t-EERKLLNSKEQLRKKCEHLKRRLDLLSSS-....
H0ZQJ1_TAEGU/399-429                 ....SEEHRLIAEKEQLRRRREQLKHKLEQLRNCC....
M3ZII1_XIPMA/401-431                 ....SDEQRLVSLKEQLRRKSELLKQRLAQLQGSR....
I3K8Y8_ORENI/390-418                 ...q--ERKLLAKKDELRKRSRELKQRLQQLRTS-....
Q6UG91_SSV2/7-30                     ....------VTELEQLRRENEELKKKLEAIAN--n...
F7IB97_CALJA/388-418                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
MYC_FELCA/408-438                    ....AGEQKLISEKDLLRKRREQLKHKLEQLRNSC....
H0WRX5_OTOGA/421-451                 ....AEEQKLISEKDLLRKGREQLKHKLEQLRNSC....
I3M553_ICTTR/422-452                 ....AEEQKLISEKDLLRKRREQLKQKLEQLRNSC....
A0A0D9RCK4_CHLSB/408-438             ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
M7BQH3_CHEMY/271-301                 ...t-DEHRLIAEKEQLRKRREQLKHKLEQLRNSC....
F1PW15_CANLF/408-438                 ....AEEQKLLSEKDLLRKRREQLKHKLEQLRNS-g...
MYC_PANTR/408-438                    ....AEEQKLISEEDLLRKRREQLKHKLEQLRNSC....
W5MZP0_LEPOC/368-397                 ....ADEQRLISLKEQLRRKSEQLKHRLAQLRS--p...
H3DIC7_TETNG/386-416                 ....SDEQRLLQLKEQLSRKSELLKQRLAQLHGSR....
J9JU58_ACYPI/337-364                 ....--EKKMLAEKKVLRKANEILKNRLTQIYSS-....
A0A286XIG5_CAVPO/407-437             ....AEEQKLLSDKDLLRKRREQLKHKLDQLRNSC....
A0A1V4KVF0_PATFA/401-431             ....SDEHRLIAEKEQLRRRREQLKHKLEQLRNSC....
A0A1U7RVT0_ALLSI/207-237             ...t-DEHRLIAEKEQLRRRRDQLKHKLEQLRNSC....
F6X065_MONDO/442-472                 ....AEEQKLSTESELLRKEQLQLKLKLERLQNSC....
A0A0P7V0S8_9TELE/160-188             ....SDEQRLISLKEQLRRRSEHLKNRLEQLRN--....
S9X162_CAMFR/261-291                 ....AEEQKLISEKDVLRKRREQLKLKLEQLRNSC....
Q9DFB9_ICTPU/359-389                 ....ADERRLLSMKEQLRRKSELLKHRLQQLRRS-q...
G1NRT5_MELGA/159-189                 ....SDEHRLIAEKEQLRRRREQLKHKLEQLRNSR....
A0A1S3NCS6_SALSA/410-440             ...t-DEQRLVNFKEQLTRKSEHLKQKLARLQDS-h...
MYC_SHEEP/408-438                    ....AEEQKLISEKDVLRKRREQLKLKLEQIRNSC....
G7PCT8_MACFA/408-438                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
MYC_MOUSE/408-438                    ....ADEHKLTSEKDLLRKRREQLKHKLEQLRNS-g...
A0A1I7Q473_MACMU/423-453             ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
F7FXT9_ORNAN/151-181                 ....AEEHKLIAEKEQLRRRREQLKHKLEQLRNFC....
W5PDV5_SHEEP/392-422                 ....AEEQKLISEKDVLRKRREQLKLKLEQIRNSC....
K7FM32_PELSI/293-323                 ...t-DEHRLIAEKEQLKKRRDQLKHKLDQLRNSC....
MYC_PIG/408-438                      ....AEEQKLVSEKDVLRKRREQLKLKLEQLRNSC....
MYC_CHICK/385-415                    ....SDEHRLIAEKEQLRRRREQLKHKLEQLRNSR....
L5K5M7_PTEAL/409-439                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
A0A1S3FVS9_DIPOR/401-431             ...v-EEQKLASEKDLLRKRREQLKHKLEQLRNSC....
G3NKK9_GASAC/368-398                 ...t-DEQRLLSLKEQLRRKSELLRQRLAHLHSSR....
D8LS55_ECTSI/20-48                   ....ADEKKHSAEVDQLKRTNEQLKTTLEQM----ls..
G3UBM1_LOXAF/410-439                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNS-....
F6PFR6_MONDO/117-144                 ...s---RKLPTEPEELRKKAIQLKNKLQQ-----dags
L9JL37_TUPCH/408-438                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
F6YAJ2_HORSE/408-437                 ....AEEQKLVSEKDLLRKRREHLQLKLEQLRN--c...
M3YHU3_MUSPF/56-85                   eeqd---RRALSIKEQLQREHRFLKRRLEQLS---m...
H0YBT0_HUMAN/422-452                 ....AEEQKLISEEDLLRKRREQLKHKLEQLRNSC....
U3JIP7_FICAL/405-435                 ....SDEHRLIAEKEQLRRRREQLKHKLEQLRNCC....
MYC_CANLF/408-438                    ....AEEQKLLSEKDLLRKRREQLKHKLEQLRNS-g...
Q6NRN4_XENLA/390-420                 ...e-DERRLIRETEQLKYRKEQLKQRLQQLRNS-v...
A0A1D5Q496_MACMU/424-454             ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
A0A0P7V442_9TELE/358-385             ...m-ESQRLSAKKDKLRQRQEQLKLRLEQLR---....
W5K5K0_ASTMX/362-392                 ....SDEQKLLSIKEQLRRKSEQLKHRLQLLRRS-q...
H2TBR0_TAKRU/385-415                 ....SDEQRLLLLKEQLNRKSELLKQRLAQLQGSR....
G1T737_RABIT/409-439                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
G3SNI5_LOXAF/411-440                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNS-....
MYCA_DANRE/379-408                   ....-DEQRLLSIKEQLRRKSEQLKHRLQQLRSS-h...
H0ZQJ0_TAEGU/401-431                 ....SEEHRLIAEKEQLRRRREQLKHKLEQLRNCC....
M3WHW1_FELCA/69-98                   eeqd---RRALSIKEQLQREHRFLKRRLEQLS---v...
F1RC36_DANRE/380-409                 ....-DEQRLLSIKEQLRRKSEQLKHRLQQLRSS-h...
A0A151P7W6_ALLMI/138-168             ...t-DEHRLIAEKEQLRRRRDQLKHKLEQLRNSC....
MYC_RAT/408-438                      ....ADEHKLISEKDLLRKRREQLKHKLEQLRNS-g...
A0A091FZ86_9AVES/222-252             ....SDEHRLIAEKEQLRRRREQLKHKLEQLRNSC....
L5M1M2_MYODS/408-438                 ...g-EEHKLLSEKDFLRKRREQLKHKLEQLRNSC....
W5MZP7_LEPOC/368-397                 ....ADEQRLISLKEQLRRKSEQLKHRLAQLRS--p...
A0A1U7TIM8_TARSY/311-341             ....AEEQKLVAEKGLLRQRREHLKHRLEQLRNSC....
H2PR71_PONAB/422-452                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
G9KC04_MUSPF/422-452                 ...t-EEQKLISEKDLLRKRREQLKHKLEQLRNS-g...
G1R0L9_NOMLE/423-453                 ...g-EEQKLTSEKDLLRKRREQLKHKLEQLRNSC....
MYCB_DANRE/367-396                   ...e-DEQRLISLKEQLRRKCEHLKQRLEQLSCS-....
F8WFG7_RAT/408-438                   ....ADEHKLISEKDLLRKRREQLKHKLEQLRNS-g...
A0A1D5R6Y1_MACMU/423-453             ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
H0ZQJ2_TAEGU/387-415                 ....SEEHRLIAEKEQLRRRREQLKHKLEQLRN--....
A0A096N777_PAPAN/408-438             ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
A0A286XSY1_CAVPO/106-135             eeqd---RRALSIKEQLQREHHFLKRRLEQLS---v...
A0A2I3SFA1_PANTR/423-453             ....AEEQKLISEEDLLRKRREQLKHKLEQLQNSC....
A0A0Q3Q8U6_AMAAE/385-415             ....SDEHRLIAEKEQLRRRREQLKHKLEQLRNSC....
A0A1L8FTT4_XENLA/161-189             ...e-DERRLIRETEQLKYRKEQLKQRLQQLRN--....
I3JFX0_ORENI/402-432                 ....SDEQKLLSLKEQLRRRSEQLKQRLAHLQGC-r...
A0A087WVR4_HUMAN/423-453             ....AEEQKLISEEDLLRKRREQLKHKLEQLRNSC....
F8WID3_MOUSE/423-453                 ....ADEHKLTSEKDLLRKRREQLKHKLEQLRNS-g...
F7I481_CALJA/422-452                 ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
G5B9M9_HETGA/361-391                 ....AEEQSLLSQKDLLRKRREQLKHRVEQLRNS-s...
A0A1S3LUE5_SALSA/369-399             ...m-DEQKLLLLKEQLRKKSEQLTSRLEQLRNS-q...
H3BC94_LATCH/382-410                 ....AEEQRLTVEKEQLRRKREQLKHKLAQLQS--....
S7QEW7_MYOBR/408-438                 ...g-EEHKLLSEKDFLRKRREQLKHKLEQLRNSC....
G1KK08_ANOCA/412-442                 ...e-DEHKLLAEKEQLRRRQEQLKNKLQQLRNSC....
A0A2K5MUW0_CERAT/423-453             ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
MYC_BOVIN/408-438                    ....AEQQKLKSEIDVLQKRREQLKLKLEQIRNSC....
A0A2K5JM08_COLAP/423-453             ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
A0A087WSQ0_MOUSE/422-452             ....ADEHKLTSEKDLLRKRREQLKHKLEQLRNS-g...
A0A2I2UI75_FELCA/508-538             ....AGEQKLISEKDLLRKRREQLKHKLEQLRNSC....
G1M831_AILME/421-451                 ...t-EEQKLISEKDLLRKRREQLKHKLEQLRNS-g...
A0A093GH59_DRYPU/246-276             ....SDEHRLIAEKEQLRRRREQLKHKLEQLRNSC....
G1QCG9_MYOLU/409-439                 ...g-EEHKLLSEKDCLRKRREQLKHKLEQLRNSC....
A0A1U7QQI6_MESAU/409-439             ....AEEHKLISEKDLLRKRREQLKHKLEQLRNS-g...
W5KXP7_ASTMX/361-390                 ....AEERRLLSVKEQLRRRCEHLKHRLEQLSNS-....
H3BYR3_TETNG/359-389                 ....SDEQRLLQLKEQLSRKSELLKQRLAQLHGSR....
G1M6Z5_AILME/53-82                   eeqd---RRALSIKEQLQREHRFLKRRLEQLS---m...
A0A087WUS5_HUMAN/423-453             ....AEEQKLISEEDLLRKRREQLKHKLEQLRNSC....
G3RS08_GORGO/423-453                 ....AEEQKLISEEDLLRKRREQLKHKLEQLRNSC....
A0A087Y5Y0_POEFO/402-432             ....SDEQRLVSLKEQLRRKSELLKQRLAQLQGSR....
A0A099ZEV6_TINGU/216-246             ....SDEHRLIAEKEQLRRRREQLKHKLEQLRNSC....
H2QWQ2_PANTR/408-438                 ....AEEQKLISEEDLLRKRREQLKHKLEQLQNSC....
A0A2K5MVB9_CERAT/408-438             ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
H0W5I8_CAVPO/96-125                  eeqd---RRALSIKEQLQREHHFLKRRLEQLS---v...
B2RSN1_MOUSE/423-453                 ....ADEHKLTSEKDLLRKRREQLKHKLEQLRNS-g...
Q0VCC9_BOVIN/106-135                 eeqd---RRALSIKEQLQREHRFLKRRLEQLS---a...
U3J2T2_ANAPL/169-199                 ....SDEHRLIAEKELLRRRREQLKHKLEQLRNSR....
F1QDI6_DANRE/331-359                 ....SENQRLTSKRDKLRERQEQLKARLEQLK---r...
Q6P1T1_XENTR/387-415                 ...e-DERRLIRETEQLKYRREQLKQRLQQLRN--....
MYC_MACMU/408-438                    ....AEEQKLISEKDLLRKRREQLKHKLEQLRNSC....
G3I0K0_CRIGR/42-71                   eeqd---RRALSIKEQLQREHRFLKRRLEQLS---v...
MYC_HUMAN/408-438                    ....AEEQKLISEEDLLRKRREQLKHKLEQLRNSC....
#=GR MYC_HUMAN/408-438         SS    ....HHHHHHHHHHHHHHHHHHHHHHHHHHHCTTX....
F6PX41_MOUSE/422-452                 ....ADEHKLTSEKDLLRKRREQLKHKLEQLRNS-g...
A0A087Y5W6_POEFO/401-431             ....SDEQRLVSLKEQLRRKSELLKQRLAQLQGSR....
A0A1S3QA70_SALSA/367-397             ...t-DEQRLVNLKEQLRRKSEHLKQKLAQLQNSC....
H2TBQ9_TAKRU/385-415                 ....SDEQRLLLLKEQLNRKSELLKQRLAQLQGSR....
#=GC SS_cons                         ....HHHHHHHHHHHHHHHHHHHHHHHHHHHCTTX....
#=GC seq_cons                        ....u-Ep+LlSEK-.LR+RREQLKHKLEQLRNS.....
//
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