GenomeNet

Database: Pfam
Entry: Nab2p_Zf1
LinkDB: Nab2p_Zf1
Original site: Nab2p_Zf1 
#=GF ID   Nab2p_Zf1
#=GF AC   PF18260.2
#=GF DE   Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF05700
#=GF GA   25.00 25.00;
#=GF TC   26.00 26.00;
#=GF NC   22.30 20.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   23994011
#=GF RT   Two singular types of CCCH tandem zinc finger in Nab2p
#=GF RT   contribute to polyadenosine RNA recognition.
#=GF RA   Martinez-Lumbreras S, Santiveri CM, Mirassou Y, Zorrilla S,
#=GF RA   Perez-Canadillas JM;
#=GF RL   Structure. 2013;21:1800-1811.
#=GF DR   INTERPRO; IPR041044;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found in nuclear polyadenylated RNA-binding 2
#=GF CC   protein (Nab2p) present in Saccharomyces cerevisiae. Nab2p is a
#=GF CC   major family of Poly A-binding proteins whose interactions are
#=GF CC   thought to be crucial for the control of poly(A) tail length.
#=GF CC   This domain is the first of seven CCCH zinc fingers which are
#=GF CC   responsible for polyadenosine RNA binding. When combined with
#=GF CC   the next three zinc fingers (Zf1-4), these four zinc fingers
#=GF CC   together may bind RNA in the 3' to 5' direction [1].
#=GF SQ   26
#=GS A0A0C7N4X6_9SACH/241-266  AC A0A0C7N4X6.1
#=GS A0A1G4IMX3_9SACH/233-258  AC A0A1G4IMX3.1
#=GS G8BPK2_TETPH/231-257      AC G8BPK2.1
#=GS I2H5Z6_TETBL/260-286      AC I2H5Z6.1
#=GS A0A120K1W1_9SACH/213-238  AC A0A120K1W1.1
#=GS S6E0P1_ZYGB2/211-237      AC S6E0P1.1
#=GS G0VEB8_NAUCC/224-250      AC G0VEB8.1
#=GS Q75E99_ASHGO/203-228      AC Q75E99.1
#=GS G8JQZ8_ERECY/223-248      AC G8JQZ8.1
#=GS G0WG17_NAUDC/223-249      AC G0WG17.1
#=GS J5PV67_SACK1/230-256      AC J5PV67.1
#=GS A0A1G4K0L0_9SACH/205-230  AC A0A1G4K0L0.1
#=GS J7S062_KAZNA/272-298      AC J7S062.1
#=GS H2ANE5_KAZAF/217-243      AC H2ANE5.1
#=GS C5E402_ZYGRC/203-229      AC C5E402.1
#=GS G8ZXT9_TORDC/209-235      AC G8ZXT9.1
#=GS C5E2M7_LACTC/231-256      AC C5E2M7.1
#=GS NAB2_YEAST/252-278        AC P32505.1
#=GS NAB2_YEAST/252-278        DR PDB; 3ZJ1 A; 253-278;
#=GS W0T5M6_KLUMD/225-249      AC W0T5M6.1
#=GS A7TJL5_VANPO/261-287      AC A7TJL5.1
#=GS A0A1G4M9Q3_LACFM/201-226  AC A0A1G4M9Q3.1
#=GS Q6CKL1_KLULA/222-247      AC Q6CKL1.1
#=GS A0A1G4K6S5_9SACH/255-280  AC A0A1G4K6S5.1
#=GS Q6FU17_CANGA/246-272      AC Q6FU17.1
#=GS A0A1E4S9B0_CYBJN/196-219  AC A0A1E4S9B0.1
#=GS A0A1X7R7M3_9SACH/230-256  AC A0A1X7R7M3.1
A0A0C7N4X6_9SACH/241-266             ..NFVN.KKQGRCQVFPRCPLGKNCPHSH
A0A1G4IMX3_9SACH/233-258             ..NVVS.KKQGRCQVFPRCPLGKNCPHAH
G8BPK2_TETPH/231-257                 .t-VIHqKKEGRCKLFPHCPLGRSCPHAH
I2H5Z6_TETBL/260-286                 ..NFIHkKKEGRCKLFPHCPLGKSCPHAH
A0A120K1W1_9SACH/213-238             ..NVIP.KKDGRCKLFPRCPLGKFCPHAH
S6E0P1_ZYGB2/211-237                 ..NFVHtRKEGRCKVFPRCPLGRSCPHAH
G0VEB8_NAUCC/224-250                 ..NFVRhKKEGRCKVFPHCPLGKSCPHAH
Q75E99_ASHGO/203-228                 ..NIIP.KKEGRCQLFPRCPLGKFCPHAH
G8JQZ8_ERECY/223-248                 ..NIIP.RKEGRCKLFPRCPLGKFCPHAH
G0WG17_NAUDC/223-249                 ..NFVNqKKEGRCKLFPHCPLGRSCPHAH
J5PV67_SACK1/230-256                 ..NFVPiKKEGRCRLFPHCPLGRSCPHAH
A0A1G4K0L0_9SACH/205-230             ..NFVQ.KKQGRCPLFPRCPLGKQCPHAH
J7S062_KAZNA/272-298                 ..NFVPkRKEGRCKLFPHCPLGKACPHAH
H2ANE5_KAZAF/217-243                 ..NFTRqKKEGRCKLFPHCPLGRSCPHAH
C5E402_ZYGRC/203-229                 ..NFVHsKKEGRCKVFPRCPLGKSCPHAH
G8ZXT9_TORDC/209-235                 ..NFVHqKKEGRCRLFPRCPLGRSCPHAH
C5E2M7_LACTC/231-256                 ..NVVQ.KKQGRCKLFPRCPLGRQCPHAH
NAB2_YEAST/252-278                   ..NFTPtKKEGRCRLFPHCPLGRSCPHAH
#=GR NAB2_YEAST/252-278        SS    ..X-------S--SSTTS-TTTTT-SS--
W0T5M6_KLUMD/225-249                 .t--VI.KREGRCPDFPHCPLGRKCTRGH
A7TJL5_VANPO/261-287                 ..NVVHhKKEGRCKLFPRCPLGRSCPHAH
A0A1G4M9Q3_LACFM/201-226             ..NVVQ.KKQGRCKLFPRCPLGRQCPHAH
Q6CKL1_KLULA/222-247                 .h-VVI.KREGRCPDFPHCSLGRKCPRGH
A0A1G4K6S5_9SACH/255-280             ..NFVS.KKQGRCQVFPRCPLGKTCPHAH
Q6FU17_CANGA/246-272                 ..NFVRtKKEGRCKVFPHCPLGRSCPHAH
A0A1E4S9B0_CYBJN/196-219             qi----.KKKGRCDKFPHCPLGKNCMYAH
A0A1X7R7M3_9SACH/230-256             ..NYVSkKREGRCKLFPHCPLGRSCPHAH
#=GC SS_cons                         ..X-------S--SSTTS-TTTTT-SS--
#=GC seq_cons                        ..NhVp.KKEGRC+LFP+CPLG+sCPHAH
//
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