#=GF ID   Ntox21
#=GF AC   PF15526.10
#=GF DE   Novel toxin 21
#=GF PI   Toxin_46; Toxin_46_; Toxin_21;
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   de Souza RF;0000-0002-5284-4630
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   [2]
#=GF GA   25.00 25.00;
#=GF TC   25.40 27.00;
#=GF NC   24.40 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   24657090
#=GF RT   CdiA from Enterobacter cloacae delivers a toxic ribosomal RNase
#=GF RT   into target bacteria.
#=GF RA   Beck CM, Morse RP, Cunningham DA, Iniguez A, Low DA, Goulding
#=GF RA   CW, Hayes CS;
#=GF RL   Structure. 2014;22:707-718.
#=GF RN   [2]
#=GF RM   22731697
#=GF RT   Polymorphic toxin systems: comprehensive characterization of
#=GF RT   trafficking modes, processing, mechanisms of action, immunity
#=GF RT   and ecology using comparative genomics.
#=GF RA   Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL   Biol Direct. 2012;7:18.
#=GF DR   INTERPRO; IPR028190;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Bacterial genomes and plasmids encode a variety of peptide and
#=GF CC   protein toxins that mediate inter-bacterial competition.
#=GF CC   Bacteriocins are diffusible proteins that parasitize
#=GF CC   cell-envelope proteins to enter and kill bacteria.
#=GF CC   Contact-dependent growth inhibition (CDI) is one mechanism of
#=GF CC   inter-bacterial competition. Novel Toxin 21 (alternatively 16S
#=GF CC   rRNA endonuclease CdiA) belongs to a family of prokaryotic
#=GF CC   polymorphic toxin systems implicated in intra-specific conflicts
#=GF CC   [1]. This RNase toxin found in bacterial polymorphic toxin
#=GF CC   systems, is proposed to adopt the BECR
#=GF CC   (Barnase-EndoU-ColicinE5/D-RelE) fold, with two conserved lysine
#=GF CC   residues and [DS]xDxxxH, RxG[ST] and RxxD motifs. In bacterial
#=GF CC   polymorphic toxin systems, the toxin is usually exported by the
#=GF CC   type 2, type 4, type 5 or type 7 secretion systems. This is also
#=GF CC   referred to as the E. cloacae CdiAC. The CdiAC proteins carry a
#=GF CC   variety of sequence-diverse C-terminal domains, which represent
#=GF CC   a collection of distinct toxins [2]. Many CdiA-CT toxins have
#=GF CC   nuclease activities. In accord with the structural homology,
#=GF CC   CdiA-CT cleaves 16S rRNA at the same site as colicin E3 and this
#=GF CC   nuclease activity is responsible for growth inhibition [1].
#=GF SQ   71
#=GS A0A090YLY6_PAEMA/1900-1967  AC A0A090YLY6.1
#=GS J2LDI7_9HYPH/2550-2618      AC J2LDI7.1
#=GS A0A5B0FUW0_9BACT/2-42       AC A0A5B0FUW0.1
#=GS A0A2T0S464_9ACTN/2193-2260  AC A0A2T0S464.1
#=GS A0A2U3AEE8_9BACL/158-229    AC A0A2U3AEE8.1
#=GS Q9K122_NEIMB/157-225        AC Q9K122.1
#=GS A0A6B2S7A5_9ACTN/1435-1503  AC A0A6B2S7A5.1
#=GS S2YVI0_9ACTN/1442-1510      AC S2YVI0.1
#=GS R7DJZ7_9BACT/36-102         AC R7DJZ7.1
#=GS F4QI11_9CAUL/29-95          AC F4QI11.1
#=GS A0A291QW57_9BACT/86-153     AC A0A291QW57.1
#=GS A0A0L0WAI4_GOTPU/9-80       AC A0A0L0WAI4.1
#=GS A0A2U3AFD8_9BACL/3-53       AC A0A2U3AFD8.1
#=GS A0A1B1U6D7_9HELI/53-122     AC A0A1B1U6D7.1
#=GS A0A291R150_9BACT/66-133     AC A0A291R150.1
#=GS Q7N722_PHOLL/47-115         AC Q7N722.1
#=GS A0A820U3Y0_9BILA/17-74      AC A0A820U3Y0.1
#=GS A0A2M8S487_9PAST/177-245    AC A0A2M8S487.1
#=GS R4T474_9PSEU/962-1030       AC R4T474.1
#=GS A0A1H4AEP5_9MICO/735-802    AC A0A1H4AEP5.1
#=GS A0A816GF27_9BILA/17-70      AC A0A816GF27.1
#=GS A0A814Z3W3_ADIRI/23-97      AC A0A814Z3W3.1
#=GS A0A085G8S6_9GAMM/251-319    AC A0A085G8S6.1
#=GS A0A820WJE1_9BILA/16-91      AC A0A820WJE1.1
#=GS A0A1I1MBC0_9ACTN/1420-1487  AC A0A1I1MBC0.1
#=GS A0A2D3UIX6_STRC0/2-69       AC A0A2D3UIX6.1
#=GS A0A1E3KWY1_9BACL/120-190    AC A0A1E3KWY1.1
#=GS A0A2N0ZJA6_9BACI/13-55      AC A0A2N0ZJA6.1
#=GS A0A6C2YH32_9BACT/170-233    AC A0A6C2YH32.1
#=GS A0A1G8ICQ0_9ACTN/62-129     AC A0A1G8ICQ0.1
#=GS A0A543B1T2_9ACTN/168-222    AC A0A543B1T2.1
#=GS A0A1I1TKF8_9ACTN/181-248    AC A0A1I1TKF8.1
#=GS A0A4R3YFL1_9GAMM/202-270    AC A0A4R3YFL1.1
#=GS B5CLC8_9FIRM/408-484        AC B5CLC8.1
#=GS A0A815QFD7_ADIRI/76-148     AC A0A815QFD7.1
#=GS A0A066UAH1_9GAMM/19-74      AC A0A066UAH1.1
#=GS A0A8A4TLT7_9BACT/3286-3353  AC A0A8A4TLT7.1
#=GS A0A127W380_SPOPS/147-221    AC A0A127W380.1
#=GS A0A128ECV3_9PROT/11-88      AC A0A128ECV3.1
#=GS A0A815ZEN4_9BILA/17-70      AC A0A815ZEN4.1
#=GS A0A264Y856_9BACT/2093-2155  AC A0A264Y856.1
#=GS W1JAA7_9GAMM/2-66           AC W1JAA7.1
#=GS A0A7H8K3K5_9ACTN/1-66       AC A0A7H8K3K5.1
#=GS A0A318XKU7_9FIRM/350-426    AC A0A318XKU7.1
#=GS A0A844LP54_9BACI/61-133     AC A0A844LP54.1
#=GS C7Q0B8_CATAD/1404-1480      AC C7Q0B8.1
#=GS A0A2M8GZP0_9VIBR/755-830    AC A0A2M8GZP0.1
#=GS D8DWX4_PREBR/3-63           AC D8DWX4.1
#=GS A0A1M7MBX4_9FIRM/4-71       AC A0A1M7MBX4.1
#=GS A0A0D0Q1I8_KITGR/2681-2749  AC A0A0D0Q1I8.1
#=GS A0A4S2UKZ5_9ACTN/424-501    AC A0A4S2UKZ5.1
#=GS A0A841DEH6_PLAVE/795-866    AC A0A841DEH6.1
#=GS D3UXB4_XENBS/442-512        AC D3UXB4.1
#=GS A0A4Y9FH42_9STRE/88-160     AC A0A4Y9FH42.1
#=GS A0A820EKB1_9BILA/17-91      AC A0A820EKB1.1
#=GS A0A1H6EVJ2_9ACTN/2356-2427  AC A0A1H6EVJ2.1
#=GS Q5F6H0_NEIG1/157-225        AC Q5F6H0.1
#=GS A0A3G8ZQD3_9ACTN/2-55       AC A0A3G8ZQD3.1
#=GS A0A1G7VIL1_9BACL/119-187    AC A0A1G7VIL1.1
#=GS A0A2U2P9N3_9SPHI/1-49       AC A0A2U2P9N3.1
#=GS A0A084ZMK2_9ENTR/164-230    AC A0A084ZMK2.1
#=GS A0A100Y231_9ACTN/2256-2333  AC A0A100Y231.1
#=GS M4RL51_BIBTR/48-116         AC M4RL51.1
#=GS A0A0M8TU03_9ACTN/158-229    AC A0A0M8TU03.1
#=GS A0A1T0B4N5_9PAST/287-355    AC A0A1T0B4N5.1
#=GS V6JUQ5_STRNV/2160-2237      AC V6JUQ5.1
#=GS A0A4V3C5K7_9ACTN/15-82      AC A0A4V3C5K7.1
#=GS A0A1V3ISV8_9PAST/586-654    AC A0A1V3ISV8.1
#=GS A0A852U0W0_9ACTN/409-483    AC A0A852U0W0.1
#=GS K0EQ33_NOCBR/69-139         AC K0EQ33.1
#=GS A0A365H5F3_9ACTN/2208-2279  AC A0A365H5F3.1
A0A090YLY6_PAEMA/1900-1967             ...............................AAAKKLGYT.....K.....T.....N.F-....TSHGQPVFKKGNK...-....-YITPDV......D......G......HN.GGIWKMAD...SVKNLGS.KSTRMGTYDENL.T.WIGD.........
J2LDI7_9HYPH/2550-2618                 ..............................i-AAEALGFA.....K.....I.....N.ET....IHGGQAVYKKGNL...-....-YITRDL......D......G......HN.GGAWKMAT...SVKNLGT.KENRLGTYDENL.N.RIGD.........
A0A5B0FUW0_9BACT/2-42                  ..........................srhwp---------.....-.....-.....-.--....-------------...-....----KDG......S......S......HN.GGVWKS--...-LKRVGN.RLERTGTLDKNL.N.RIKD.........
A0A2T0S464_9ACTN/2193-2260             .............................dr--AAALGYK.....S.....RipaqrA.PF....NSHGQVVFSDGKN...-....-YITPDV......D......G......HNvSDGWKM--...----FNR.RGQRIGTYDADL.N.----ylk......
A0A2U3AEE8_9BACL/158-229               ..............................e-VAKELGYS.....V.....L.....A.NK....YSHGEKIFYNKKG...K...pKYITIDK......D......S......HN.GGTWKGAK...TIEGLAS.KKTRSGTYDIEL.N.RIGD.........
Q9K122_NEIMB/157-225                   ...............................AAAKELGYR.....K.....I.....K.ER....TRNDAAIFKKGKS...-....-YISRDV......D......S......HN.GGAWKEAS...SPEKLNR.KETRNGTFDKNL.N.RIGD.........
A0A6B2S7A5_9ACTN/1435-1503             .............................dr--AAELGYK.....T.....RippqrA.PF....HSHGQEVFSNGKN...-....-YITPDV......D......G......HNvSDGWKV--...----FNK.KGQRIGTYDADL.N.YI--kk.......
S2YVI0_9ACTN/1442-1510                 .............................dr--AAELGYK.....R.....RispqkA.PF....NSHGQEVFSNGKN...-....-YITPDV......D......G......HNvSDGWKM--...----FNK.KGQRIGTYDADL.N.YI--kk.......
R7DJZ7_9BACT/36-102                    .........................tvkipe------GYR.....L.....I.....N.E-....-RGKSKIFYNGKN...-....-YISPDI......D......G......HN.GGIWKMGK...TIKDLNS.KDRRMGTFDENL.N.RI--kk.......
F4QI11_9CAUL/29-95                     ........................dlakwnk-------WA.....E.....E.....K.NK....FSHGQPVFYDKQT...R....RYFSYDV......D......G......HN.GGIWKSAK...SVDALKS.KSTRLGTYDH--.-.----tgq......
A0A291QW57_9BACT/86-153                ..........................iklpk------GFK.....K.....T.....N.L-....VSHGQKVYSDVKR...-....-WITPDK......D......G......HN.GGVWKVYD...NPNDVGKnKKHRDGTYDSDL.N.KIGN.........
A0A0L0WAI4_GOTPU/9-80                  .............................ad-------YK.....L.....L.....K.GF....RSHGQKVYKHKKK...R....LYITRDIgs.gngR......S......HK.GGAWKMAI...KPEYLLS.KKTRLGTYNEDL.SiRIGD.........
A0A2U3AFD8_9BACL/3-53                  .......................ilnfatep---------.....-.....-.....-.--....-------------...-....KYITIDK......D......S......HN.GGTWKGAK...TIEGLAS.KKTRSGTYDIEL.N.RIGD.........
A0A1B1U6D7_9HELI/53-122                ..............................k-IAKELGYQ.....K.....T.....N.R-....KSHGETIYQHTKK...R....SVITRDT......D......S......HS.GGAWKEAK...TADDLTP.-TRRNGTFNKDLtE.RIG-k........
A0A291R150_9BACT/66-133                ..........................iklpk------GFK.....K.....T.....N.L-....VSHEQKVYSDGKR...-....-WITPDK......D......G......HN.GGVWKVYD...NPNDVGKnKKHRDETYDSDL.N.KIGN.........
Q7N722_PHOLL/47-115                    ..............................e-AAGKLGFD.....R.....RiappkA.PF....NSHGQPVFFDGKT...-....-YITPDV......D......S......HNvTNGWKMFD...------R.RGKRMGTYDSDL.N.RVK-d........
A0A820U3Y0_9BILA/17-74                 .........................elivaq------GYR.....K.....T.....N.M-....RLHGRSVYYNPQK..pNn..iQYITYDV......D......G......HN.GGVWKAGN...-------.------------.-.----kkwaengvt
A0A2M8S487_9PAST/177-245               ..............................k-VAKELGYT.....R.....T.....N.YR....TKSDAVIFKKGNS...-....-YITRDV......D......G......HN.GGAWKEAS...SPEKLNK.KETRNGTFDINL.N.RIGD.........
R4T474_9PSEU/962-1030                  ...............................SMAKALGFQ.....T.....T.....N.Y-....KSHGAPVYRQGSN...-....RYITPDV......D......S......HI.GGVWKMAT...SVINLGS.KRTRMGTYDANL.K.KIGD.........
A0A1H4AEP5_9MICO/735-802               ..............................a-LAKLNGWQ.....Q.....T.....N.R-....TSNGQPIFKVGKN...-....-YVSYDV......D......G......HN.GGVWKMAR...TPEALAS.KSTRMGTYDSNL.N.RIGD.........
A0A816GF27_9BILA/17-70                 ..........................klida-----QGYK.....K.....T.....K.I-....RLHGRSVYHNPKQp.eN...mQYITYDK......D......G......HN.GGVWKAGN...-------.------------.-.----kkwae....
A0A814Z3W3_ADIRI/23-97                 .........................aasppa------GYT.....R.....T.....N.L-....ICMGKAVFCNPKA...Ns.alTCITEDR......T......G......HI.GGVWKGGSk.kWAESGCP.ANTRSGTYNAAL.Q.RVG-k........
A0A085G8S6_9GAMM/251-319               ..............................e-AAKNLGFG.....Q....rIpp.qkA.PF....DSHGQPVFYNGKN...-....-YISPDV......D......S......HNvANGWKM--...----FNS.KGKRIGTYDSDL.N.RIKD.........
A0A820WJE1_9BILA/16-91                 ..........................yavev-----LKFQ.....K.....T.....N.L-....LAHGVAVYRNSKR..pNa..tEYITYDV......D......G......HV.GGVWKAGDkkwAEGGCKQ.KPARSGTYDKDL.N.KIAD.........
A0A1I1MBC0_9ACTN/1420-1487             .............................dr--ARELGYP.....R.....RippqrA.PF....DSHGQPVFTNGKR...-....-YITPDI......D......G......HNvSNGWKVF-...-----DR.KGRRIGTYDANL.N.Y---vk.......
A0A2D3UIX6_STRC0/2-69                  ..............gagalgygrriapqkap---------.....-.....-.....-.-F....NSHGQDVFSNGKN...-....-YITPDI......D......G......RNvSGGWKVFS...------R.RGDRIGIYDADL.N.YI--kn.......
A0A1E3KWY1_9BACL/120-190               ..............................t-AAKLLGFE.....K.....V.....N.G-....GRAKAAVFYSKDR...G....IYITRDIprqstgS......T......DN.GGVWKMAP...TVEDLMS.R-----TYNKHL.N.RIGD.........
A0A2N0ZJA6_9BACI/13-55                 ..................ikrikpiatniid---------.....-.....-.....-.--....-------------...-....-------......-......-......--.GGVWKGAS...YIKNSGS.RKTRSGTYDAEI.E.----nr.......
A0A6C2YH32_9BACT/170-233               ................aaamngwqevanpgf---------.....-.....-.....-.--....NSHGQPVFTNGRS...-....-FFTPDA......D......G......HI.GGVWK---...---QFNQ.QGQRVGTLDANL.N.RLG-k........
A0A1G8ICQ0_9ACTN/62-129                .............................dr--AGALGYK.....TripaqK.....A.PF....NSHGQVVFFNGKN...-....-YITPDV......D......G......HNvTDDWKM--...----FNR.KGQRIGTYDPDL.N.----ylk......
A0A543B1T2_9ACTN/168-222               ....................fegrkhssipk---------.....-.....-.....-.--....-------------...K....MYIVQDT......T......S......HI.GGVWKIAK...SSAALNR.KKTRTATTDALL.T.EFG-g........
A0A1I1TKF8_9ACTN/181-248               ............qraaalgyarrippqrvpf---------.....-.....-.....-.--....DSHGQDAYSNGKE...-....-YITPDV......D......G......HNvTDGWKR--...----FDR.SGARTGTYDASL.-.----ryvk.....
A0A4R3YFL1_9GAMM/202-270               ..............................e-AAKNLGFD.....R.....RippqkA.PF....NSHGQPVFSNGKN...-....-YITPDV......D......S......HNvTDGWKVY-...-----NN.RGKRIGTYDSDL.I.KIK-d........
B5CLC8_9FIRM/408-484                   ..............................q-AAKKLGYE.....K.....T.....N.YR....AKNGEPIYYNKKT...K....TYISQDI......G......SadgsgpHN.GGVWKMGK...SPQELNS.KSTRLGTYDGNL.N.RIGD.........
A0A815QFD7_ADIRI/76-148                ...............................SIANKLGYV.....T.....Q.....SgNK....LCHGQKVHYNKKKs.kN...mQCITQDC......D......T......HS.GRAWKIGT..iSWCEGGC.RGQRTGTYELD-.-.----avt......
A0A066UAH1_9GAMM/19-74                 ......................gvktnqypf---------.....-.....-.....-.--....NSHGQPVYKKGNR...-....-YITPDV......D......S......HN.GGVWKIFD...N------.KGKRLGTADANL.-.----rif......
A0A8A4TLT7_9BACT/3286-3353             ..............................n-IALEKGFR.....K.....T.....N.Y-....RSHGQAVYTDGKR...-....-YLTIDV......D......S......HN.GGAFKMGD...SIKSLKS.KTTRSGTYNEKL.E.RIGE.........
A0A127W380_SPOPS/147-221               ...............................AAAKKLGYK.....K.....I.....S.E-....KCGKAAIFDKVKKstkG...pGFISRDI......D......N......HSgKAAWKGGT...SPQNLCS.KDRRSGTYDTKL.D.RVAD.........
A0A128ECV3_9PROT/11-88                 npkklkkkknnkvkfnktssdnlinlkdvkl---------.....-.....-.....-.--....--------KSKKD...N....SYIAKDL......D......S......HN.GGAWKEAS...KPDKLES.KKTRNGTFDKDM.K.RI--.........
A0A815ZEN4_9BILA/17-70                 ..........................klida-----QGYK.....K.....T.....K.IR....-LRGRSVYHNPKQp.eN...mQYITYDN......D......G......HK.GGVWKAGN...-------.------------.-.----kkwae....
A0A264Y856_9BACT/2093-2155             ..............................d------GYR.....K.....I.....K.G-....FSHGIPVYTNGKN...-....-YITPDV......D......G......HN.GGIWKMGK...SVKALQN.KHTRMGTYNAIL.K.RIGD.........
W1JAA7_9GAMM/2-66                      ..................gydqripaqkapf---------.....-.....-.....-.--....NSHEQTVFYNRKT...K....NYITPDV......D......G......HNiTNSWKMMD...------K.KGKRMGTYDSEL.N.RIKD.........
A0A7H8K3K5_9ACTN/1-66                  ..............................m---------.....-.....-.....-.-K....SAGGAPIWENKKA...GggqpRYITYDR......T......G......HNkQAVFKGASf.rNPFQSTK.DSARDGTYGLDV.S.PTG-e........
A0A318XKU7_9FIRM/350-426               ...............................AAAKELGYE.....P.....T.....N.YV....TKSGEKVFYNKKT...K....TYISQDV......GsgngmgS......HN.GGVWKAAK...SPEALNS.KDTRLGTYDANM.N.RIGD.........
A0A844LP54_9BACI/61-133                ...............................AAAKDLGYS.....A.....T.....K.Y-....ISHGQKVFKRGKK...Gk.gpKYITVDK......D......G......HN.GGVWKGAS...TVKKLGS.KKTRSGTYDAEL.K.RIGD.........
C7Q0B8_CATAD/1404-1480                 ...............................DVAKYLGYK.....K.....T.....K.EM....SAGKQPIWVNKKA...GggqpKYITYDR......T......G......HS.GGIFKGASf.eKPFQTTK.DTGRDGTYDLDV.D.GSGN.........
A0A2M8GZP0_9VIBR/755-830               ..............................e-AAQILGFV.....K.....I.....K.E-....KSHGEVVYYNKKR...K....LYMSRDV......G......SgdgngaHN.GGVWKLAK...SPKELGS.KQTRLGTFDADL.K.QIGD.........
D8DWX4_PREBR/3-63                      .............................pk------GFK.....L.....A.....R.EF....MSHNEKVYEYNGK...-....-YYSFDN......T......S......HN.GGVWKVF-...--VKNGG.KLHRIGTADKNL.N.----ifk......
A0A1M7MBX4_9FIRM/4-71                  ...............................DAAKNLGFS.....K.....I.....K.E-....KSHGQPIYKKGNK...-....-YITPDI......D......G......HN.GGVWKMAN...SIKNLAS.KATRMGTYDINL.V.RIGD.........
A0A0D0Q1I8_KITGR/2681-2749             ..............................r-IAKKMGFK.....K.....D.....P.T-....NSEKAAVYEKDGF...-....-FISRDL......D......V......HS.GGGWKGAT...SIKNLRT.KKTRSGTYCKHLcH.RIGD.........
A0A4S2UKZ5_9ACTN/424-501               ...............................DVADYLGYT.....K.....T.....N.KR....SAGGAPIWENKKAt.gGq..pRYITYDR......T......G......HNkQAVFKGANf.rNPFQSTK.DSARDGTYGLDI.S.----pdgk.....
A0A841DEH6_PLAVE/795-866               ..............................k-LASHLGYT.....N.....T.....R.KR....SAAKTHIWENKKA...N...pRYITWDR......N......G......HK.GGIFKGANf.kDPFRSTK.DSARDGTYDLDY.-.----sng......
D3UXB4_XENBS/442-512                   ...............................DAAKKLGYD.....QripaqK.....A.PF....NSHGQTVFFNKKT...K....TYITPDV......D......G......HNvNNGWKMMD...------K.KGKRIGTYDSEL.N.RL--kd.......
A0A4Y9FH42_9STRE/88-160                ..............................k-LAKELGYK.....K.....V.....N.ER....GKHGMPIYERVKG..kG...pNFISPDH......A......S......HK.GGYWQGAD...TKEKLLD.KKARKGTYDKYL.N.RIAD.........
A0A820EKB1_9BILA/17-91                 ..........................klive-----QGYR.....K.....S.....N.I-....RLHGRSVYYNPKQ..pNn..iQYITYDV......D......G......HN.GGVWKAGNk.kWAESGGR.SASRSGTYDENL.K.KIGD.........
A0A1H6EVJ2_9ACTN/2356-2427             ...............................DLAKYLGYA.....K.....T.....N.F-....KVRGQIVFWNKKT...K....TYISQDIgh..gdG......S......HN.GGTWKIAD...SVEGLGR.KETRTATTDALL.N.----vl.......
Q5F6H0_NEIG1/157-225                   ...............................AAAKKLGYR.....K.....I.....K.ER....TRNDAAIFKKGKS...-....-YISRDV......D......S......HN.GGAWKEAS...SPKNLNR.KETRNGTFDKNL.N.RIGD.........
A0A3G8ZQD3_9ACTN/2-55                  ............................apl---------.....-.....-.....-.--....------VWVGTND...K....NFITQDI......D......I......YN.GGTWKMAK...SVAALGS.KTTRSGTYDYDL.T.YIG-p........
A0A1G7VIL1_9BACL/119-187               ...............................DLANYLGFK.....I.....V.....K.GA....SIKKQPVYTNGKI...-....-FISPDV......D......S......HI.GGVWKAAK...TIKDLGS.KETRYGTYDVFL.N.YVG-k........
A0A2U2P9N3_9SPHI/1-49                  .............................ml---------.....-.....-.....-.--....---KQKVYKKGNK...-....-YYSRDV......D......S......HN.GGAWKVF-...--ERQGN.KLKRVGTADKDL.N.----if.......
A0A084ZMK2_9ENTR/164-230               ..............................e-AAKNLGFD.....R....rI.....P.QQkapfNSHGQPVYSDGKN...-....-YITPDI......D......S......HNvTNGWKMFD...------R.KGNRIGTYDSNL.T.----gl.......
A0A100Y231_9ACTN/2256-2333             ...............................DVANFLGYT.....R.....T.....K.MK....SAGGAPIWENKKA...GggqpRYITYDR......T......G......HNkQAVFKGASf.rNPFQSTK.DSARDGTYGLDV.S.PTG-e........
M4RL51_BIBTR/48-116                    ..............................l-VAKELGYI.....K.....T.....N.YR....TKSGAAVFKKGNS...-....-YITRDI......D......G......HN.GGAWKEAS...SPEKLNK.KETRNGTFDINL.N.KIGD.........
A0A0M8TU03_9ACTN/158-229               ...............................DLAKYLGYR.....D.....E.....G.T-....RLKGQKIFTNGKT...-....-FISQDIgn..gdG......S......HN.GGTWKIAK...SVKALGS.KSSRTATTDALL.N.PIG-c........
A0A1T0B4N5_9PAST/287-355               .............................ep--ARRLGYKdrippQ.....K.....A.PF....NSHGQPVYSNGKN...-....-YITPDI......D......G......HNvSDGWKMFD...------K.KGKRLGTYDKNL.N.RIKD.........
V6JUQ5_STRNV/2160-2237                 ...............................DIAGYLGYT.....K.....T.....N.KR....SAGGAAIWENKKA...GagqpRYVTYDR......T......G......HNkEAVFKGADf.rNPFQSTK.DSARDGTYGLDV.S.PTG-e........
A0A4V3C5K7_9ACTN/15-82                 ................dlaktsgprgaiyvv---------.....-.....-.....-.--....--KGERVFQRGGS...-....-YIVQDT......T......A......HS.GGVWKIAT...SVKELGS.KNTRTATTDALL.N.VIG-r........
A0A1V3ISV8_9PAST/586-654               ..............................k-AAERLGYK.....Q.....RippqkA.PF....NSHGQDVYWNGKN...-....-YITPDV......D......G......HNvSEGWKLF-...-----DR.KGQRLGTYDKDL.N.RVK-d........
A0A852U0W0_9ACTN/409-483               ..............................r-LATGLGYE.....P.....T.....G.Q-....TSHGQPVFKRSKKa.pKs.lpKFISGDV......D......V......HN.GGDFKGAN...SIDALGS.KETRSGTYKIAY.D.ESG-k........
K0EQ33_NOCBR/69-139                    ...............................AAARDLGYA.....V.....A.....N.VG....KSHGCLIFKHEKK...N....LYISQDV......D......G......HN.GGRWKMAS...SPENLAS.KKTRMGTYDANL.N.RIGD.........
A0A365H5F3_9ACTN/2208-2279             ..............................h-LANYLGYR.....D.....T.....G.K-....IIKGQKIFTNGKT...-....-FISQDVgd..gdG......S......HN.GGTWKIAK...SIKALGS.KATRTATTDALL.N.EIG-c........
#=GC seq_cons                          .................................At.hGap.....p.....h.....t.......ps+GpsVapssKp.........YIT.Dl......D......u......HN.GGsWKhup...s.tthsp.KtsR.GTYDtsL.s.tlt..........
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