#=GF ID Ntox37
#=GF AC PF15535.10
#=GF DE Bacterial toxin 37
#=GF PI Toxin_57; Toxin_37;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 27.80 27.80;
#=GF TC 27.90 30.30;
#=GF NC 27.20 27.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR029108;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted RNase toxin found in bacterial polymorphic toxin
#=GF CC systems. The toxin possesses an all-beta fold and a conserved
#=GF CC glutamate residue, and [KR] and Hx[DH] motifs. In bacterial
#=GF CC polymorphic toxin systems, the toxin is exported by the type 2
#=GF CC or type 7 secretion systems [1].
#=GF SQ 29
#=GS A0A844B0Q2_9BURK/22-109 AC A0A844B0Q2.1
#=GS S8AQW5_DACHA/82-156 AC S8AQW5.1
#=GS G1XD12_ARTOA/66-146 AC G1XD12.1
#=GS A0A323V2A5_9RHOO/93-176 AC A0A323V2A5.1
#=GS A0A7G8W2G3_9BURK/3391-3477 AC A0A7G8W2G3.1
#=GS A0A7V8VGW4_9BACT/26-93 AC A0A7V8VGW4.1
#=GS A0A0T6UVH5_9PSED/851-912 AC A0A0T6UVH5.1
#=GS Q7NYN4_CHRVO/191-279 AC Q7NYN4.1
#=GS A0A2Z6GEA8_9PROT/268-351 AC A0A2Z6GEA8.1
#=GS A5UT36_ROSS1/201-262 AC A5UT36.1
#=GS A0A328YQC2_9BURK/299-385 AC A0A328YQC2.1
#=GS A0A2H5WYS4_9BACT/171-243 AC A0A2H5WYS4.1
#=GS A0A0Q6MAP2_9BURK/245-332 AC A0A0Q6MAP2.1
#=GS R5KJQ6_9CLOT/217-279 AC R5KJQ6.1
#=GS R5XUP5_9FIRM/260-323 AC R5XUP5.1
#=GS D6YV35_WADCW/221-293 AC D6YV35.1
#=GS Q5YN02_NOCFA/330-413 AC Q5YN02.1
#=GS A0A507ZMH7_9GAMM/687-767 AC A0A507ZMH7.1
#=GS A0A1N2FF53_9MYCO/335-427 AC A0A1N2FF53.1
#=GS A0A1W2C5T1_9FIRM/520-581 AC A0A1W2C5T1.1
#=GS A0A849CBK7_9NOCA/370-432 AC A0A849CBK7.1
#=GS A0A7X6R7E7_9NOCA/330-415 AC A0A7X6R7E7.1
#=GS A0A0H5DQB4_9BACT/152-221 AC A0A0H5DQB4.1
#=GS A0A6G7Y0L3_9FIRM/634-692 AC A0A6G7Y0L3.1
#=GS A0A125P1N9_9BURK/231-318 AC A0A125P1N9.1
#=GS A0A1B1YRK4_9GAMM/614-677 AC A0A1B1YRK4.1
#=GS A0A7W9UHA9_9NOCA/330-413 AC A0A7W9UHA9.1
#=GS F8L2C9_PARAV/1655-1717 AC F8L2C9.1
#=GS A0A323URH7_9RHOO/161-242 AC A0A323URH7.1
A0A844B0Q2_9BURK/22-109 .........akppkdakepeg------........-----A.K..APG....kPGEAEGLKDPKGG-ENW...VRNPN-.GRgYgwqgadggvwc....ptgpdtgstgdaH..GGPHWDVQYPGG..RYD...NVYPGG......
S8AQW5_DACHA/82-156 ..................tddAKAPGKpt...eadGYVASK.R..GDRlvreeDGKRKGWED-KKG-DLW...IPTGP-.GRlA...........................H..GGPHWDVQKKRG..GYT...NVYPN-r.....
G1XD12_ARTOA/66-146 ...................epAKAPGK........------.-..---.....PKKEDGFEPPKGKSDSG...MKAPSS.GG.Kkgwpdkkgniw....kpsgptngdgsrGphGGPHWDVEDPDG..NHW...NVYPGG......
A0A323V2A5_9RHOO/93-176 .....................NKPPEN........AYDPNG.P..KAPg...kPGADEGFVDPKGG-DNW...VPNPN-.GKgWgwedskgdv........wcptgqggsaH..GGPHWDVQTPGG..GYR...NVRPK-r.....
A0A7G8W2G3_9BURK/3391-3477 .....................AKPPQN........AYDPSG.P..KAPg...kPREDVGFEEPSGG-DQW...VPNPNP.GR.Gggsygwldan......gnvwvpsgqggRahGGAHWDVQSPGG..GYK...NVRP--p.....
A0A7V8VGW4_9BACT/26-93 ...............pgsnpt-KAPP-........GFEWRA.KpgSTP.....GSREGNYYNPRTREVLRp.dLSDPDP.--.-...........................-..IGPHWDYIDPNM..NRW...RIFPDG......
A0A0T6UVH5_9PSED/851-912 .....................TQPPGE........GWEWRG.K..GTP.....GSREGAWYNPSSGESLHd.dRTHPPG.--.-...........................-..KDPHVTYTDPTG..KRW...DNYGNG......
Q7NYN4_CHRVO/191-279 .........nkppkdatdpng------........-----A.K..APG....kPGRTEGFCEPKKGAPTW...GRAPN-.GRgSgwidadgnvwv....ptgpssgstgdaH..GGPHWDVQKPGG..GYD...NVYPGG......
A0A2Z6GEA8_9PROT/268-351 ....................m-KPPKD........AYDPNGaK..APG....qPGDGDGFCEPKKG-PKW...GRSPN-.GRgNgwvdndgnv........wvptglggeaH..GGPHWDVQRPGG..GYD...NVYPGG......
A5UT36_ROSS1/201-262 .....................AQPPAP........GWMWRG.K..DPP.....GGIKGAWYNPSTKESLHp.dLQHPPP.--.-...........................-..IGPHWDYKDASG..TRW...RVFPNG......
A0A328YQC2_9BURK/299-385 ....................i-KPPAN........AYDPNG.P..KAPg...kPSEADGFKSPKGG-DNW...VPNPNP.GK.Ggsswgwqdakg....dvwcptgqggnaH..GGPHWDVQTPGG..DYR...NVKP--r.....
A0A2H5WYS4_9BACT/171-243 ........ppeigdwywkpqn--PPAP........GWVWRG.R..GEP.....GSSQGSWHNPDTGESLHp.dLGHGTP.--.-...........................-..DGPHWDYIDPQG..RKY...RYYPDG......
A0A0Q6MAP2_9BURK/245-332 ....................v-KPPEN........AYDSDG.-..-PKap.gkPGEAEGFKDPKGG-ENW...VRNPN-.GRgYgwqaadggvwc....ptgpdsgstgdaH..GGPHWDVEYPGG..RYH...NIYPGG......
R5KJQ6_9CLOT/217-279 .....................NKAPGK........DFEWRG.N..PDI.....KKNIGNWFNKKTGESFHw.dMDHPDP.--.-...........................-..IGPHWDYFRRDI.dNEY...RIFPD-n.....
R5XUP5_9FIRM/260-323 .....................NKAPGK........NYEWRG.G..SID.....-ENKGGWYNPKTKETLHw.dMRHPEP.--.-...........................-..HGPHWDYINKNG..GWEngyRIFPNG......
D6YV35_WADCW/221-293 .....................NKTAEElhqmfvdkGYDYGA.R..SPEl...lIRGKGNYINPKNGRQFH...IDPKNS.GR.Y...........................R..EPNHVDVSRPEK..-YN...GSLPKK......
Q5YN02_NOCFA/330-413 ....................y-KPPAN........AYDPNG.P..KAPg...rPGDAEGFVPPKGG-DRW...VPNPN-.GRgFgwedadgnv........wvptgqggaaH..GGPHWDVEFPKG..GYK...NVRPGG......
A0A507ZMH7_9GAMM/687-767 .............qmnessdg------........-----A.Q..APG....mPGTDDGYECPKNWDGKK...VKSPN-.GRgYgwpdkkgn..........vwvptgpgsGahGGPHWDVQRPGG..GYI...NVYPGG......
A0A1N2FF53_9MYCO/335-427 ....................y-KPPGD........AFDKTGaK..APG....qPGTAEGFVPPKAG-DRW...VPNPSArG-.KnrfgwedadgnvwvptgpgsparpgdaH..GGPHWDVIDKNG.kKIK...DAYPGG......
A0A1W2C5T1_9FIRM/520-581 ....................v-KVPAE........GYEWRG.N..GVP.....GSKYGNWYNPNTKEWLRp.dLNHPEP.--.-...........................-..IAPHWDYGASNG..KTY...RIFPDG......
A0A849CBK7_9NOCA/370-432 ..................tqp--PAGP........GWEWRG.Q..NPP.....GGDRGAWFNPQTQQSIHp.dLNHPDP.--.-...........................-..IGPHFDFKPRNE..PGW...RIFPDG......
A0A7X6R7E7_9NOCA/330-415 ....................y-KPPAN........AYDPDG.P..KAPg...rPGEAEGFVPPKGG-DRW...VPNPSPkGPrFgwedadgnv........wvptgqgsvaH..GGPHWDVQGKDG..SYD...NIYPGG......
A0A0H5DQB4_9BACT/152-221 ........nksakeldamfrk------........----KG.F..DPEgp.daLNGLGNYINRKNGRQYH...I-DPKHvGR.Y...........................A..EPNHVDVGRAKA..Y-S...------gnlgkk
A0A6G7Y0L3_9FIRM/634-692 ....................k-QSPGA........GWEWRG.-..---.....PEDKGSWFNPSTGETLHp.nLNHPMP.--.-...........................-..EGPHWDYIPYKN.gPQY...RLYPDG......
A0A125P1N9_9BURK/231-318 .....................AKPPEN........AYDPIG.P..KAPg...kPGAVEGFNDPKGG-EDW...VRNPNP.GR.Ggsshgwqddr......grvwcptgqggRahGGPHWDVELPNG..RQV...NVPPG-q.....
A0A1B1YRK4_9GAMM/614-677 ...................pk-QCPPE........-YEWRG.K..SGAq...pGSKEGNYYNPTTKEILRp.dLSHEPP.--.-...........................-..IGPHWDYRDATG..KWY...RLFPDG......
A0A7W9UHA9_9NOCA/330-413 ....................y-KPPAN........AYDPNG.P..KAPg...rPGDAEGFVPPKGG-DRW...VPNPN-.GRgFgwedadgn..........vwvptgqggGahGGPHWDVQNPKG..GYR...NVRPKG......
F8L2C9_PARAV/1655-1717 .....................TKCPGE........EYTWKG.D..GPP.....GSGEGAWYNGKTKESLYp.dLNHPLP.--.-...........................-..KGPHWDYRDRKT.eYEE...RLFLDG......
A0A323URH7_9RHOO/161-242 apgeipnvdwsdpskppkgsd----GK........DWEWRG.K..PPQ.....GGEKGGYVNPTNPDQSVhpdLNHPAP.--.-...........................-..VGPHWDFTDRGRtpPGW...RVFPDG......
#=GC seq_cons ......................KsPsp........ua-.pG.t..sss.....suctsuahsPKsG.sha...lssPss...................................tGPHWDhpsssG..shh...plaPsG......
//
