GenomeNet

Database: Pfam
Entry: Orf78
LinkDB: Orf78
Original site: Orf78 
#=GF ID   Orf78
#=GF AC   PF06024.14
#=GF DE   Orf78 (ac78)
#=GF PI   DUF912;
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_8809 (release 9.0)
#=GF GA   28.00 28.00;
#=GF TC   28.00 28.20;
#=GF NC   27.90 27.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   23698311
#=GF RT   The Autographa californica multiple nucleopolyhedrovirus Orf78
#=GF RT   is essential for budded virus production and general occlusion
#=GF RT   body formation.
#=GF RA   Tao XY, Choi JY, Kim WJ, Lee JH, Liu Q, Kim SE, An SB, Lee SH,
#=GF RA   Woo SD, Jin BR, Je YH;
#=GF RL   J Virol. 2013;87:8441-8450.
#=GF RN   [2]
#=GF RM   25087880
#=GF RT   Disruption of the baculovirus core gene ac78 results in
#=GF RT   decreased production of multiple nucleocapsid-enveloped
#=GF RT   occlusion-derived virions and the failure of primary infection
#=GF RT   in vivo.
#=GF RA   Li SN, Wang JY, Yuan MJ, Yang K;
#=GF RL   Virus Res. 2014;191:70-82.
#=GF DR   INTERPRO; IPR009261;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Family members include Autographa californica nuclear
#=GF CC   polyhedrosis virus (AcMNPV), AC78 or Orf78. AC78 is a late gene
#=GF CC   in the viral life cycle and encodes an envelope structural
#=GF CC   protein that plays an essential role in embedding the
#=GF CC   occlusion-derived virus (ODV) in the occlusion body [1].
#=GF CC   Although AC78 is not essential for budding virus formation or
#=GF CC   nucleocapsid assembly and ODV formation, number are
#=GF CC   significantly reduced if the gene is knocked-out [2].
#=GF SQ   16
#=GS A0A6A5B8U0_NAEFO/18-108   AC A0A6A5B8U0.1
#=GS Q80LN4_NPVAH/3-102        AC Q80LN4.1
#=GS A0A063BVC7_USTVR/254-344  AC A0A063BVC7.1
#=GS AC78_NPVAC/3-104          AC Q06693.1
#=GS A0A0B5E865_9ABAC/3-117    AC A0A0B5E865.1
#=GS A0A109WZD6_9BBAC/16-102   AC A0A109WZD6.1
#=GS Q8B9H6_NPVR1/3-104        AC Q8B9H6.1
#=GS Q0GYE4_9ABAC/3-104        AC Q0GYE4.1
#=GS B5X069_9ABAC/3-110        AC B5X069.1
#=GS Q1HH23_NPVAP/3-98         AC Q1HH23.1
#=GS Q9J856_9ABAC/3-126        AC Q9J856.1
#=GS A0A183MAX1_9TREM/4-80     AC A0A183MAX1.1
#=GS B7SVW3_9ABAC/3-121        AC B7SVW3.1
#=GS Q6JPC5_NPVNC/1-92         AC Q6JPC5.1
#=GS A0A024WFD9_PLAFA/4-94     AC A0A024WFD9.1
#=GS Q598P4_9ABAC/42-149       AC Q598P4.1
A0A6A5B8U0_NAEFO/18-108              .......aherten--------------------------................NYNNNNNLVYTIYATNSTTHHNVTASSSQt.....dsGTSTERVVLVCLLLLVVSVLLVVMVFAIYYWMKKRRER.KEQM...------eatqqlpqsq.
Q80LN4_NPVAH/3-102                   ..............FDIPYDKLSSNAKVDYIPLKLALSDI................DENGHTKNNSENDINKNYLLNNHIDNGI-........--TEKTNINIIIVSLAVVLSMCIIFFIIYYFVILRRDR.YSAT...INPNV-v..........
A0A063BVC7_USTVR/254-344             platsslltqplqq--------------------------................-QQQQQQLQQLQQQQKQQQQQQQQQQQQQ........QQQQQQQQHVVVVVVVVVVVVVVVVVVVVVVVVVEQQAaQSQV...QQ----ppcv.......
AC78_NPVAC/3-104                     ..............LDVPYYRLGNHEKVEYIPLKLALND-................--DTASEPQQFSEPVHKMPINDMVGYDNT........-TSNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQ.QYSD...------sidtdspfv..
A0A0B5E865_9ABAC/3-117               ..............LNVPYERLVATAKVDYIPLKLALNDLyddggg...ggndsnnAKQASNEPKIDINTPPMTGYGA------Ttta..aamPLQQKQMYDALVLGMLTFFCILVLLYAIYYFVILRDSQ.NPPL...-RPSY-i..........
A0A109WZD6_9BBAC/16-102              .........dlitk---------SNVKVEPIPLKLAHNN-................NNTTTAN----------NSNNEFKNTNND........-TNNFTVSTIMWITLSCIIFMLVVVFLVSYFIFNNNTE.DYDS...------fneeyg.....
Q8B9H6_NPVR1/3-104                   ..............LDVPYYRLGNHEKVEYIPLKLALND-................--DIASEPQQFSEPVHKMPINDMVGYDNT........-TSNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQ.QYSD...------sidtdspfv..
Q0GYE4_9ABAC/3-104                   ..............LDVPYYRLGNHEKVEYIPLKLALND-................--DTASEPQQFSEPVHKMPINDMVGYDNT........-TSNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQ.QYSD...------sidtdspfv..
B5X069_9ABAC/3-110                   ..............LDIPYDRLGVNDKVDYIPLKLAISDFn..............vDAADLGNNTDDSSTKSILGHNDLTSYRSNy.....qkRNNSTWIGNILLISLLAVFCVMVLLYALYYFVILRERR.KSIV...RQPYYV...........
Q1HH23_NPVAP/3-98                    ..............LEVPYYRLGSHERVEYIPLKLALND-................EAPAADAA--------AYDYGEASKADAP........-ANQAPVGLIVLISLVAFVALFLLLYVIYYFLILRERP.QYSDdaeN-----dpafv......
Q9J856_9ABAC/3-126                   ..............LDVPYERLGTATKVDYIPLKLALTDLpenniss..sssssvdDYDNNDKNKTLSTAKNQRPKVDIDLTDRNlqlrqpsaDLSKQQFYNSLVLGLLTFFCVLVLLYAIFYFVILRDRQ.KSIV...-KPSYM...........
A0A183MAX1_9TREM/4-80                ...rrehllesnvt--------------------------................----------K-ATNNNNNHSNYLQNDEI........EFEMFHLTNNLLIILLSVLCIIIILLLLIYIVYRRLRH.HQHH...HDSQY-f..........
B7SVW3_9ABAC/3-121                   ..............LDVPYERLGTSTKVDYIPLKLALTDLpetnggggngggenegK----NNDGTKNDQPKIDITDRAKSQQTTtt...ttsVQSKQQFYDALVLGLLTFFCILVLLYAIYYFVILRDRQ.KSTI...-KPSYM...........
Q6JPC5_NPVNC/1-92                    .............m-NIDYNKISDDVSVKTYPLKVNIPET................IATKNLSPRETTDSSTDDATSNNDTNTTN........--FVWQLLSICIVGLLIIVGIIVLLYFL----------.----...------ssrddgqaeii
A0A024WFD9_PLAFA/4-94                ...........pdf--------------QAIPLK-AQ-EI................VTQGTKAADAKTAEVSSRIAADITTKQTT.......aINSTYASYEITIIASIVAIVVIVLIMVIIYL-ILRYRR.KTKM..kKKLQ--yi.........
Q598P4_9ABAC/42-149                  ..............LDIPYERLSPTLTVKYIPLKLALNDIp..............dTSNGETANNKNSNDSATAPKVNITVPEKRny...dtnVASPKQMYDVLVLGMLTVFCILVLLYAIYYFVILRDRQ.KPT-...------epril......
#=GC seq_cons                        ..............hslPY.+Lusp.+V-YIPLKLAlsD...................sssspspphspsspptstsshsstsss.........tsphphhpllllullshlsllVLLYsIYYFVILRcpp.p.p.....................
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