GenomeNet

Database: Pfam
Entry: Orthopox_35kD
LinkDB: Orthopox_35kD
Original site: Orthopox_35kD 
#=GF ID   Orthopox_35kD
#=GF AC   PF02250.16
#=GF DE   35kD major secreted virus protein 
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Mian N;0000-0003-4284-4749
#=GF SE   Pfam-B_3549 (release 5.2)
#=GF GA   21.90 21.90;
#=GF TC   24.50 27.30;
#=GF NC   20.40 18.90;
#=GF BM   hmmbuild --amino HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   9123853
#=GF RT   The T1/35kDa family of poxvirus-secreted proteins bind
#=GF RT   chemokines and modulate leukocyte influx into virus-infected
#=GF RT   tissues. 
#=GF RA   Graham KA, Lalani AS, Macen JL, Ness TL, Barry M, Liu LY, Lucas
#=GF RA   A, Clark-Lewis I, Moyer RW, McFadden G; 
#=GF RL   Virology 1997;229:12-24.
#=GF DR   INTERPRO; IPR003184;
#=GF DR   SCOP; 1cq3; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This family of orthopoxvirus secreted proteins (also known as T1
#=GF CC   and  A41) interact with members of both the CC and CXC
#=GF CC   superfamilies of  chemokines. It has been suggested that these
#=GF CC   secreted proteins  modulate leukocyte influx into virus-infected
#=GF CC   tissues [1].
#=GF SQ   21
#=GS Q0NNY6_9POXV/1-59        AC Q0NNY6.1
#=GS Q6TV76_9POXV/30-283      AC Q6TV76.1
#=GS Q77TH2_VACCT/51-218      AC Q77TH2.1
#=GS Q9ICB6_VACCT/16-243      AC Q9ICB6.1
#=GS E2CZP2_9POXV/20-259      AC E2CZP2.1
#=GS C23L_VACCW/16-243        AC Q805H7.1
#=GS C23L_VAR67/27-252        AC P34016.1
#=GS A41_VAR67/57-217         AC P33854.1
#=GS Q9PX83_MYXVL/20-259      AC Q9PX83.1
#=GS Q0NNY7_9POXV/1-80        AC Q0NNY7.1
#=GS Q85307_CWPXB/29-245      AC Q85307.1
#=GS Q85307_CWPXB/29-245      DR PDB; 1CQ3 B; 7-223;
#=GS Q85307_CWPXB/29-245      DR PDB; 1CQ3 A; 7-223;
#=GS Q8QMR3_CWPXB/51-217      AC Q8QMR3.1
#=GS U5TFL9_COWPX/51-218      AC U5TFL9.1
#=GS Q0NP46_9POXV/52-218      AC Q0NP46.1
#=GS A0A1L3IZA1_9POXV/50-247  AC A0A1L3IZA1.1
#=GS Q6TVK8_ORFSA/33-287      AC Q6TVK8.1
#=GS F1AXE7_ORFV/1-207        AC F1AXE7.1
#=GS D3IZR1_9POXV/35-281      AC D3IZR1.1
#=GS VT1_RFVKA/21-257         AC P25946.1
#=GS A41_VACCW/59-218         AC P24766.1
#=GS A41_VACCW/59-218         DR PDB; 2VGA A; 39-198;
#=GS A0A223FN63_9POXV/26-279  AC A0A223FN63.1
Q0NNY6_9POXV/1-59                   .............m-------------------.---------------------.-------------........-....---------.......................---------------------...-.---------.---------------.-----.-.---.........------------.......................-----------..-.-------.-.-------...-------..---.--..I...VDTKCVKNLEFSVRIGDMC...KESSDLEVKDGFKYVDGSASEG..ATDDT...SLIDSTKLKAC...........
Q6TV76_9POXV/30-283                 .............w-CRIHKDKLYSRFRLYMKI.TR-TTVTPPTGMC--MLDIEN.SNMDLDETDEVTNvtstisfrD....STATFEASG.......................VNGSITLMGDEVHIPMSYIGVsfdP.---------.SSAYVFVNVSSWTPWeKSTTD.L.AANdfeglkniiNHQILAINLGCDhqypapkp.......tpkpekisTPSTTPGPTLL..E.TEAPTTV.P.PVDTSSD...RKKKPDP..VDF.SL..L...VDTRCIKNVDLYFELKDAClayKSQSPFKLVG--QHGTGQQVRQ..DMKSL..gTSYRTCKLK--ts.........
Q77TH2_VACCT/51-218                 .ttceseihkygas-------------------.---------------------.-------------........-....---------.......................------VSNGGLNISVDLLNC..fL.NFHTVGVYT.NRDTVYAKFASLDPW.TTEPI.N.SMT.........HDDLVKLTEECI.......................VDIYLKCEVDK..T.KDFMKTNgN.RLKPRDF...KTVPPSD..VGS.MI.eL...QSDYCVNDVTAYVKIYDECgniKQHSIPTLRDYFTTKNGQP---..-----...-----------rkilkkkfdn.
Q9ICB6_VACCT/16-243                 ..............SCTEEENKHHMGIDVIIKV.TKQDQTPTNDKICQSVTEITE.SESDPDPEVESED........D....STSVEDVDP.......................PTTYYSIIGGGLRMNFGFTKC...P.QIKSISESA.DGNTVNARLSSVSPG.QGKDS.P.AIT.........HEEALAMIKDCE.......................VSIDIRCSEEE..K.DSDIKTH.P.VLGSNIS..hKKVSYED..IIG.ST..I...VDTKCVKNLEFSVRIGDMC...KESSELEVKDGFKYVDGSASEG..ATDDT...SLIDSTKLKAC...........
E2CZP2_9POXV/20-259                 ..............ICRQGEDVRYMGIDVVAKI.TK--RTTGSDTPCQGLRTTIE.SAYTED---ENED........D...gATGTEQPDDlseeyeyden...desfltgfviGSTYHTIVGGGLSVTFGFTGC...P.TVKAISEHV.KGRHVYVRLSSDAPW.RDTNP.V.SMN.........RTEALALLDTCE.......................VSVDIKCSRVN..V.TETTYGT.A.ALVPRIT...QATRRSH..IIG.ST..L...VDTECVKSLDITVQVGEMC...KRTSDLSARDSLKVKNGKLLE-..--DDI...LVLRTPTLKAC...........
C23L_VACCW/16-243                   ..............SCTEEENKHHMGIDVIIKV.TKQDQTPTNDKICQSVTEITE.SESDPDPEVESED........D....STSVEDVDP.......................PTTYYSIIGGGLRMNFGFTKC...P.QIKSISESA.DGNTVNARLSSVSPG.QGKDS.P.AIT.........HEEALAMIKDCE.......................VSIDIRCSEEE..K.DSDIKTH.P.VLGSNIS..hKKVSYED..IIG.ST..I...VDTKCVKNLEFSVRIGDMC...KESSELEVKDGFKYVDGSASEG..ATDDT...SLIDSTKLKAC...........
C23L_VAR67/27-252                   ..............SCTEEENKHYMGIDVIIKV.TKQDQTPTNDKICQSVTEITE.SESDPE--VESED........D....STSVEDVDP.......................PTTYYSIIGGGLRMNFGFTKC...P.QIKSISESA.NGNAVNARLSSVPLG.QGKDS.P.AIT.........RAEALAMIKDCE.......................LSIDIRCSEEE..K.DSDIQTH.P.VLESNIS..hKKVSYED..IIG.ST..I...VDTKCVKNLEFSVRIGDMC...KESSDLEVKDGFKYVDGSVSEG..VTDDT...SLIDSTKLKSC...........
A41_VAR67/57-217                    ......ihkygasv-------------------.---------------------.-------------........-....---------.......................-------SNGGLNISVDLLNC..fL.NFHTVGVYT.NRDTVYAKFTSLDPW.TMEPI.N.SMT.........YDDLVKLTEECI.......................VDIYLKCEVDK..T.KDFIKTN.GnRLKPRDF...KTVPPNV..GSI.IE..L...QSDYCVNDVTAYVKIYDECgniKQHSIPTLRDYFTTTNGQ----..-----...-----------prkilkkkfdn
Q9PX83_MYXVL/20-259                 ..............ICRQGEDVRYMGIDVVAKI.TK--RTTGSDTPCQGLRTTIE.SAYTED---ENED........D...gATGTEQPDDlseeyeyden...desfltgfviGSTYHTIVGGGLSVTFGFTGC...P.TVKAISEHV.KGRHVYVRLSSDAPW.RDTNP.V.SMN.........RTEALALLDTCE.......................VSVDIKCSRVN..V.TETTYGT.A.ALVPRIT...QATRRSH..IIG.ST..L...VDTECVKSLDITVQVGEMC...KRTSDLSARDSLKVKNGKLLE-..--DDI...LVLRTPTLKAC...........
Q0NNY7_9POXV/1-80                   ..............-------------------.---------------------.-------------........-....---------.......................-------------MNFGFTKC...P.QIKSISESA.DGNAVNARLSSVSPG.QGKDS.P.ALT.........REEALAMIKDCE.......................VYIDIRCSEEE..K.DSDIKTH.P.VLESNV-...-------..---.--..-...-------------------...----------------------..-----...-----------...........
Q85307_CWPXB/29-245                 ..............SCTEEENKHHMGIDVIIKV.TKQDQTPTNDKICQSVTEVTE.SEDESE-------........-....--EVV-KGD.......................PTTYYTVVGGGLTMDFGFTKC...P.KISSISEYS.DGNTVNARLSSVSPG.QGKDS.P.AIT.........REEALSMIKDCE.......................MSINIKCSEEE..K.DSNIKTH.P.VLGSNIS..hKKVSYED..IIG.ST..I...VDTKCVKNLEISVRIGDMC...KESSELEVKDGFKYVDGSASED..AADDT...SLINSAKLIAC...........
#=GR Q85307_CWPXB/29-245      SS    ..............S----TTEE-EEEEEEEEE.EE-TTS-------SEEEEEET.T-STTE-------........-....--EEE-ES-.......................-EEEEEEEETTEEEEEEEES-...-.---EEEEEE.ETTEEEEEEE---TT.SSS--.-.-EE.........HHHHHHHHHH-E.......................EEEEEEE----..-.---B--S.-.-------..-S--EE--..-EE.EE..E...EETTTEEEEEEEEEEEESS...S--CCG-EEEEEEEETTEEE--..----T...TSS-GGG-EEB...........
Q8QMR3_CWPXB/51-217                 qttceseihkygas-------------------.---------------------.-------------........-....---------.......................------VSNGGLNISVDLLNC..fL.NFHTVGVYT.NRDTVYAKFASLDPS.TEPI-.N.SMT.........HDDLVKLTEECI.......................VDIYLKCEVDK..T.KDFMKNG.N.RLKPRDF...KTVPPSN..VGS.MI.eL...QSDYCVEDVTAYVKIYDECgniKQHSIPTLRDYFTTKNGQP---..-----...-----------rkilkkkfds.
U5TFL9_COWPX/51-218                 .ttceseihkygas-------------------.---------------------.-------------........-....---------.......................------VSNGGLNISVDLLHC..fL.NFHTVGVYT.NRDTVYAKFASLDPW.TTEPI.N.SMT.........HDDLVKLTEECI.......................VDIYLKCEVDK..T.KDFMKTN.GnRLKPRDF...KTVPPSN..VGS.MI.eL...QSDYCVNDVTAYVKIYDECgniKQHSIPTLRDYFTTKNGQP---..-----...-----------rkilkkkfdn.
Q0NP46_9POXV/52-218                 ..tceseihkygas-------------------.---------------------.-------------........-....---------.......................------VSNGGLNISVDLLNC..fL.NFHTVGVYT.NRDTVYAKFASLDPW.TMEPI.N.SMT.........HDDLVKLTEECI.......................VDIYLKCEVDK..T.KDFMKTN.GnRLKPRDF...KTVPHSN..V-G.SIieL...QSDYCVNDVTAYVKIYDECgniKQHSIPTLRDYFTTKNGQP---..-----...-----------rkilkkkfdn.
A0A1L3IZA1_9POXV/50-247             ...akvnkftprct-------------------.---------------------.-------------........-....-----DVDI.......................KRNNAQVVGGGVVINTTLHGC...PfPVSTVAEEVyDDSILNTVFSTVNPI.SDKDKsN.FIT.........KLESKNLHKKCKvevsmtcvk....deptlpedssEEHDYVDEDD-..I.INETAMP.I.SVDNEIL...AAFNRNKapVIVnDM..LtvnIDKSCVKEVAVRLHVKDFCetvKRFPETSYIQEYTYPKGSS---..-----...-----------fedfeent...
Q6TVK8_ORFSA/33-287                 ..............FCSTHQNEVYARFRLQMRVgVRHSPLYTPSNMC--MMDIED.SIMDIENSTEKEY........T....SAATGDANG.......................VNVSVALIGEGVSIPLSYIGLgfnP.SL------A.DG-YLYVNVSSRAPWvQQTLD.L.SANggwginqilEKELLAIQIGCDnqkfpeeptttqppspvtttlssTTLDLTDENTD..T.TPLTTTS.A.SVN----...RKRNPDD..FDF.SL..L...VDPRCVTSVDLHVELRDACidyKEASQLSLKG--KYGDGELVKK..EIKDVgkdHNMCSLNLSPG...........
F1AXE7_ORFV/1-207                   ..............----------------MRVgVRHSPLYTPSNMC--MMDIED.STDTEDSTMEKEY........T....STATGDADG.......................LNVSVALIGEGVSIPLSYIGLgfnP.SL------T.DG-YLYVNVSSRAPWdQQTLD.L.SANdgwgikqvlEKEILAIQIGCDnqkfpeeptttqppspvtttlssTTLDPNDKNTD..T.TPTTTG-.A.SVD----...GKRNPDD..FDF.SL..I...VDPRCVTSVNLHFEIKDACmdhKESSPLS---------------..-----...-----------l..........
D3IZR1_9POXV/35-281                 ..............FCLTHNTEMYAKFRLYMRIqVRHSPMYEPSNMC--MLDLET.SRLDTD------D........L....SMAKFEANG.......................INGSIALIGEDVSIPFSYIGVgfnP.LL-------.-SRYVYVNVSSWSPWdQLTAE.L.TSYdfwglrqilAKERLIIQLGCDhqkfpeep......tprttpapqTTPEEELEEEDyeYyDELKPTP.P.NIY--VD...RKRNPGE..LDF.SL..L...ADSRCIESVDLYVELKDACinyRHTSPLRLKG--EHNNGEAVRK..EIKTLtdsHTICSMNMNP-y..........
VT1_RFVKA/21-257                    ..............ICKQDEDVRYMGIDVVVKV.TK--KTSGSDTVCQALRTTFE.AAHKGD----GAN........D....SLSTEYVDDyseeeeyey....desflegfviGSTYYTIVGGGLSVTFGFTGC...P.TVKSVSEYA.KGRIVFIRLSSDAPW.RDTNP.M.SIN.........RTEALALLEKCE.......................TSIDIKCSNET..V.SETTYGL.A.SLAPHIT...QATERGN..IIG.ST..L...VDTDCVENLDVTVHLGEMC...RKTSDLSKRDSLKVKNGELLD-..--DDT...FSIHTPKLKAC...........
A41_VACCW/59-218                    .......kygasvs-------------------.---------------------.-------------........-....---------.......................--------NGGLNISVDLLNC..fL.NFHTVGVYT.NRDTVYAKFASLDPW.TTEPI.N.SMT.........HDDLVKLTEECI.......................VDIYLKCEVDK..T.KDFMKTN.GnRLKPRDF...KTVPPSN..VGS.MI.eL...QSDYCVNDVTTYVKIYDECgniKQHSIPTLRDYFTTKNGQP---..-----...-----------rkilkkkfdn.
#=GR A41_VACCW/59-218         SS    .......TTEEEEE-------------------.---------------------.-------------........-....---------.......................--------ETTEEEEEEEES-..--.---EEEEEE.ETTEEEEEEE---TT.TSSS-.-.EEE.........HHHHHHHHHH-E.......................EEEEEEE---T..T.S-B---S.S-S--GGGE...EE----S..STT.-E.EE...E--TTEEEEEEEEEEEESSSSSSSS----EEEEEES-SS-----..-----...------------EEE-S--EE.
A0A223FN63_9POXV/26-279             ............yc---QEENKHHVGIDFLIKVgLK--DGSGNNKICQSVSYFSEdDDSDYNDEDANDY........DvlivDTLTETSDDkedtltetsdtsvetddssmtytPFNYKVLLGGGVKMIIGFMGC...P.DIKSISEYS.SGNNVYAKFSTVAPW.DDKKS.YnPMS.........YQDALDMVKKCR.......................VSVDVKCDNDD..K.DRNPLDT.K.VFGAYMSylkSMSKNKD..IID.SF..V...FDKRCVKDVEISIRIGDMC...HKHQDLMYKDHFNLVDGKETDGvdTLDDK...SN---------fksc.......
#=GC SS_cons                        .......TTEEEEES----TTEE-EEEEEEEEE.EE-TTS-------SEEEEEET.T-STTE-------........-....--EEE-ES-.......................-EEEEEEEETTEEEEEEEES-..--.---EEEEEE.ETTEEEEEEE---TT.TSSS-.-.EEE.........HHHHHHHHHH-E.......................EEEEEEE---T..T.S-BB--S.S-S--GGGE...CE-EE-S..SCC.EE.EE...EETTTEEEEEEEEEEEESSSSSSSSCCG-EEEEEECETTEEE--..----T...TSS-GGG-EEB-EEE-S--EE.
#=GC seq_cons                       .........................................................................................s..........................s.h.lhGGGLslshuahsC...P.sl+olu..s.sustVas+hSSlsPW.psps..s.uho.........+c-hLslhccCc.......................lslsl+Cpp-c..p.cshhpTs.s.sLtsp.....+pss.ss..lhs.Sh..L...hDscCVcslshhV+ItDhC...KcpS.hpl+D.aphhsGp....................................
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