GenomeNet

Database: Pfam
Entry: P53_TAD
LinkDB: P53_TAD
Original site: P53_TAD 
#=GF ID   P53_TAD
#=GF AC   PF08563.12
#=GF DE   P53 transactivation motif
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_3515 (release 19.0)
#=GF GA   20.00 20.00;
#=GF TC   20.40 20.10;
#=GF NC   19.80 18.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Motif
#=GF WK   P53
#=GF RN   [1]
#=GF RM   8875929
#=GF RT   Structure of the MDM2 oncoprotein bound to the p53 tumor
#=GF RT   suppressor transactivation domain. 
#=GF RA   Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine
#=GF RA   AJ, Pavletich NP; 
#=GF RL   Science. 1996;274:948-953.
#=GF RN   [2]
#=GF RM   16159876
#=GF RT   Structural details on mdm2-p53 interaction. 
#=GF RA   Chi SW, Lee SH, Kim DH, Ahn MJ, Kim JS, Woo JY, Torizawa T,
#=GF RA   Kainosho M, Han KH; 
#=GF RL   J Biol Chem. 2005;280:38795-38802.
#=GF DR   INTERPRO; IPR013872;
#=GF DR   SO; 0001067; polypeptide_motif;
#=GF CC   The binding of the p53 transactivation domain by regulatory
#=GF CC   proteins regulates p53 transcription activation.  This motif is
#=GF CC   comprised of a single amphipathic alpha helix and contains a
#=GF CC   highly conserved sequence [1-2].
#=GF SQ   224
#=GS A0A2I3HEB4_NOMLE/6-30     AC A0A2I3HEB4.1
#=GS A0A3Q1HGV2_9TELE/9-33     AC A0A3Q1HGV2.1
#=GS G3R2U9_GORGO/6-30         AC G3R2U9.1
#=GS W4XZV6_STRPU/15-39        AC W4XZV6.1
#=GS A0A2Y9L4Q2_ENHLU/6-30     AC A0A2Y9L4Q2.1
#=GS P53_DELLE/6-30            AC Q8SPZ3.1
#=GS A0A1U8BI05_MESAU/6-30     AC A0A1U8BI05.1
#=GS A0A2I3HA34_NOMLE/6-30     AC A0A2I3HA34.1
#=GS A0A3B5AW66_9TELE/9-32     AC A0A3B5AW66.1
#=GS H3B1Z4_LATCH/6-29         AC H3B1Z4.1
#=GS P53_CANLF/6-30            AC Q29537.2
#=GS F7GNX0_CALJA/6-30         AC F7GNX0.1
#=GS A0A3P8T0X9_AMPPE/9-33     AC A0A3P8T0X9.1
#=GS A0A2I3SYN1_PANTR/6-30     AC A0A2I3SYN1.1
#=GS A0A2K6QDJ8_RHIRO/6-30     AC A0A2K6QDJ8.1
#=GS G1MEP6_AILME/6-30         AC G1MEP6.1
#=GS A0A2I3N9A3_PAPAN/6-30     AC A0A2I3N9A3.1
#=GS C3VC56_SHEEP/6-30         AC C3VC56.1
#=GS A0A2Y9R5B9_TRIMA/6-30     AC A0A2Y9R5B9.1
#=GS P53_MACFA/6-30            AC P56423.2
#=GS L7N1B2_MYOLU/7-31         AC L7N1B2.1
#=GS A0A2K5WMY7_MACFA/6-30     AC A0A2K5WMY7.1
#=GS A0A340XCN5_LIPVE/6-30     AC A0A340XCN5.1
#=GS G3ULT4_LOXAF/6-30         AC G3ULT4.1
#=GS A0A2K6QDJ2_RHIRO/6-30     AC A0A2K6QDJ2.1
#=GS A0A2K5JJA8_COLAP/6-30     AC A0A2K5JJA8.1
#=GS A0A3B4FI32_9CICH/9-32     AC A0A3B4FI32.1
#=GS L5JZ91_PTEAL/6-30         AC L5JZ91.1
#=GS A0A3Q1AJT5_AMPOC/9-33     AC A0A3Q1AJT5.1
#=GS A0A2K5N3M9_CERAT/6-30     AC A0A2K5N3M9.1
#=GS A0A2K5RMZ8_CEBCA/6-30     AC A0A2K5RMZ8.1
#=GS A0A2K5N3J8_CERAT/6-30     AC A0A2K5N3J8.1
#=GS A0A2K5WN49_MACFA/6-30     AC A0A2K5WN49.1
#=GS A0A0G2KBB2_RAT/6-30       AC A0A0G2KBB2.1
#=GS A0A3Q3H0Q2_9LABR/12-34    AC A0A3Q3H0Q2.1
#=GS A0A3Q1AKW0_AMPOC/9-32     AC A0A3Q1AKW0.1
#=GS A0A2I3GF05_NOMLE/6-30     AC A0A2I3GF05.1
#=GS G3WS63_SARHA/4-31         AC G3WS63.1
#=GS A0A2K6QDI9_RHIRO/6-30     AC A0A2K6QDI9.1
#=GS E9PCY9_HUMAN/6-30         AC E9PCY9.8
#=GS A0A2I3T645_PANTR/6-30     AC A0A2I3T645.1
#=GS A0A2K5N3F4_CERAT/6-30     AC A0A2K5N3F4.1
#=GS A0A1D5RL03_MACMU/6-30     AC A0A1D5RL03.1
#=GS A0A2K5JJ67_COLAP/6-30     AC A0A2K5JJ67.1
#=GS A0A2K6QDJ3_RHIRO/6-30     AC A0A2K6QDJ3.1
#=GS A0A2K6LYN1_RHIBE/6-30     AC A0A2K6LYN1.1
#=GS F7A9U0_XENTR/5-29         AC F7A9U0.1
#=GS A0A3B3RR15_9TELE/78-102   AC A0A3B3RR15.1
#=GS P53_BOVIN/6-30            AC P67939.1
#=GS A0A3B4VC63_SERDU/9-33     AC A0A3B4VC63.1
#=GS A0A2K5JJ46_COLAP/6-30     AC A0A2K5JJ46.1
#=GS A0A3P8T2H3_AMPPE/9-32     AC A0A3P8T2H3.1
#=GS A0A3Q1JCZ2_ANATE/9-32     AC A0A3Q1JCZ2.1
#=GS H2QC53_PANTR/6-30         AC H2QC53.1
#=GS A0A3B4VBM7_SERDU/9-32     AC A0A3B4VBM7.1
#=GS A0A3B3VCW8_9TELE/1-25     AC A0A3B3VCW8.1
#=GS A0A2I3MD32_PAPAN/6-30     AC A0A2I3MD32.1
#=GS L9KM90_TUPCH/20-44        AC L9KM90.1
#=GS A0A2I2YTF6_GORGO/6-30     AC A0A2I2YTF6.1
#=GS A0A0G2KB75_RAT/6-30       AC A0A0G2KB75.1
#=GS A0A452G0A3_CAPHI/6-30     AC A0A452G0A3.1
#=GS A0A2R9A5Q0_PANPA/6-30     AC A0A2R9A5Q0.1
#=GS A0A2U4C2U9_TURTR/6-30     AC A0A2U4C2U9.1
#=GS A0A286XW13_CAVPO/6-30     AC A0A286XW13.1
#=GS A0A096P2R8_PAPAN/6-30     AC A0A096P2R8.1
#=GS G3T035_LOXAF/6-30         AC G3T035.1
#=GS G1RF61_NOMLE/6-30         AC G1RF61.2
#=GS A0A2K6AAI4_MANLE/6-30     AC A0A2K6AAI4.1
#=GS A0A340X8E6_LIPVE/6-30     AC A0A340X8E6.1
#=GS A0A3B4X6D0_SERLL/9-32     AC A0A3B4X6D0.1
#=GS A0A3Q7TIN0_VULVU/6-30     AC A0A3Q7TIN0.1
#=GS G1U940_RABIT/1-25         AC G1U940.1
#=GS P53_CAVPO/6-30            AC Q9WUR6.1
#=GS A0A1S3EYC1_DIPOR/29-53    AC A0A1S3EYC1.1
#=GS A0A060YN57_ONCMY/4-23     AC A0A060YN57.1
#=GS A0A2R8MB56_CALJA/6-30     AC A0A2R8MB56.1
#=GS A0A3B5Q9F8_XIPMA/13-34    AC A0A3B5Q9F8.1
#=GS W5N8V9_LEPOC/3-27         AC W5N8V9.1
#=GS A0A3B4XB19_SERLL/9-32     AC A0A3B4XB19.1
#=GS A0A2U3Y5G3_LEPWE/6-30     AC A0A2U3Y5G3.1
#=GS A0A2I3T303_PANTR/6-30     AC A0A2I3T303.1
#=GS A0A210QTK4_MIZYE/82-104   AC A0A210QTK4.1
#=GS A0A2K6SLC5_SAIBB/6-30     AC A0A2K6SLC5.1
#=GS H2U133_TAKRU/2-25         AC H2U133.2
#=GS A0A452G0L9_CAPHI/6-25     AC A0A452G0L9.1
#=GS G5B5D6_HETGA/6-30         AC G5B5D6.1
#=GS I7HIK9_MOUSE/6-30         AC I7HIK9.1
#=GS A0A3P9DU20_9CICH/7-27     AC A0A3P9DU20.1
#=GS A0A3P8ZCJ5_ESOLU/4-23     AC A0A3P8ZCJ5.1
#=GS H3CXQ0_TETNG/2-25         AC H3CXQ0.1
#=GS A0A2R9A5P4_PANPA/6-30     AC A0A2R9A5P4.1
#=GS A0A3Q3WGI5_MOLML/3-25     AC A0A3Q3WGI5.1
#=GS A0A2D0RBJ9_ICTPU/2-26     AC A0A2D0RBJ9.1
#=GS P53_HUMAN/6-30            AC P04637.4
#=GS P53_HUMAN/6-30            DR PDB; 3DAC B; 17-29;
#=GS P53_HUMAN/6-30            DR PDB; 3DAB F; 16-27;
#=GS P53_HUMAN/6-30            DR PDB; 2K8F B; 6-30;
#=GS P53_HUMAN/6-30            DR PDB; 1YCQ B; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 2MWY B; 115-129;
#=GS P53_HUMAN/6-30            DR PDB; 5HOU A; 1006-1030;
#=GS P53_HUMAN/6-30            DR PDB; 3DAB D; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 2Z5T P; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 2Z5S P; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 2Z5T R; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 2L14 B; 13-30;
#=GS P53_HUMAN/6-30            DR PDB; 2Z5S Q; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 3DAC P; 17-28;
#=GS P53_HUMAN/6-30            DR PDB; 4HFZ D; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 2Z5S R; 18-27;
#=GS P53_HUMAN/6-30            DR PDB; 1YCR B; 17-29;
#=GS P53_HUMAN/6-30            DR PDB; 4HFZ B; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 3DAB B; 17-28;
#=GS P53_HUMAN/6-30            DR PDB; 2LY4 B; 14-30;
#=GS P53_HUMAN/6-30            DR PDB; 2Z5T Q; 17-27;
#=GS P53_HUMAN/6-30            DR PDB; 5HPD A; 3006-3030;
#=GS P53_HUMAN/6-30            DR PDB; 3DAB H; 18-28;
#=GS A0A2K6AAJ8_MANLE/6-30     AC A0A2K6AAJ8.1
#=GS A0A2K5JJ56_COLAP/6-30     AC A0A2K5JJ56.1
#=GS A0A3Q3B4E6_KRYMA/6-29     AC A0A3Q3B4E6.1
#=GS E9PFT5_HUMAN/6-30         AC E9PFT5.1
#=GS A0A2Y9Q793_DELLE/6-30     AC A0A2Y9Q793.1
#=GS A0A2U3VT95_ODORO/6-30     AC A0A2U3VT95.1
#=GS A0A2K6QDI6_RHIRO/6-30     AC A0A2K6QDI6.1
#=GS A0A2K6QDH6_RHIRO/6-30     AC A0A2K6QDH6.1
#=GS A0A452GW06_9SAUR/13-34    AC A0A452GW06.1
#=GS K7G3P4_PELSI/5-29         AC K7G3P4.1
#=GS H0XGB0_OTOGA/6-30         AC H0XGB0.1
#=GS Q80ZA1_MOUSE/9-33         AC Q80ZA1.1
#=GS P53_SHEEP/6-30            AC P51664.1
#=GS A0A2K5DXG0_AOTNA/6-25     AC A0A2K5DXG0.1
#=GS G3Q6V7_GASAC/10-32        AC G3Q6V7.1
#=GS A0A2K6GZZ6_PROCO/6-30     AC A0A2K6GZZ6.1
#=GS A0A2K6GZU4_PROCO/6-30     AC A0A2K6GZU4.1
#=GS Q549C9_MOUSE/9-33         AC Q549C9.1
#=GS A0A3P9DTH1_9CICH/24-45    AC A0A3P9DTH1.1
#=GS A0A2I2ZTB3_GORGO/6-30     AC A0A2I2ZTB3.1
#=GS A0A2K5N3I9_CERAT/6-30     AC A0A2K5N3I9.1
#=GS A0A3Q4BCJ5_MOLML/9-30     AC A0A3Q4BCJ5.1
#=GS E7EQX7_HUMAN/6-30         AC E7EQX7.1
#=GS A0A3Q1JCZ8_ANATE/9-33     AC A0A3Q1JCZ8.1
#=GS A0A1S3IK29_LINUN/32-56    AC A0A1S3IK29.1
#=GS F1PI27_CANLF/8-32         AC F1PI27.1
#=GS P53_MACMU/6-30            AC P56424.1
#=GS A0A2K6LYP2_RHIBE/6-30     AC A0A2K6LYP2.1
#=GS A0A384BVC2_URSMA/6-30     AC A0A384BVC2.1
#=GS M3YC88_MUSPF/6-30         AC M3YC88.1
#=GS G3UAZ0_LOXAF/6-30         AC G3UAZ0.1
#=GS A0A2K5JJ89_COLAP/6-30     AC A0A2K5JJ89.1
#=GS A0A2K6LYM5_RHIBE/6-30     AC A0A2K6LYM5.1
#=GS A0A2K6AAH4_MANLE/6-30     AC A0A2K6AAH4.1
#=GS V4A869_LOTGI/10-34        AC V4A869.1
#=GS A0A2I2ZK26_GORGO/6-30     AC A0A2I2ZK26.1
#=GS I3KRX9_ORENI/9-33         AC I3KRX9.1
#=GS A0A096MBY3_POEFO/4-28     AC A0A096MBY3.1
#=GS A0A3Q2W984_HAPBU/9-32     AC A0A3Q2W984.1
#=GS A0A3Q3WVD8_MOLML/3-24     AC A0A3Q3WVD8.1
#=GS A0A2K6LYM9_RHIBE/6-30     AC A0A2K6LYM9.1
#=GS A0A2K6AAQ3_MANLE/6-30     AC A0A2K6AAQ3.1
#=GS P53_XIPMA/2-26            AC Q92143.2
#=GS A0A087XP53_POEFO/1-25     AC A0A087XP53.2
#=GS S4R334_HUMAN/6-30         AC S4R334.1
#=GS F7GP14_CALJA/6-30         AC F7GP14.2
#=GS A0A383YUA7_BALAS/6-30     AC A0A383YUA7.1
#=GS P53_RABIT/6-30            AC Q95330.1
#=GS A0A3P9DU35_9CICH/4-27     AC A0A3P9DU35.1
#=GS E7EMR6_HUMAN/6-30         AC E7EMR6.1
#=GS A0A2K6LYQ1_RHIBE/6-30     AC A0A2K6LYQ1.1
#=GS A0A0D9RG12_CHLSB/6-30     AC A0A0D9RG12.1
#=GS A0A3Q4HSS6_NEOBR/9-32     AC A0A3Q4HSS6.1
#=GS A0A2K5WMM5_MACFA/6-30     AC A0A2K5WMM5.1
#=GS A0A452G156_CAPHI/6-30     AC A0A452G156.1
#=GS A0A091CJU7_FUKDA/6-30     AC A0A091CJU7.1
#=GS P53_MOUSE/9-33            AC P02340.4
#=GS H2NSL2_PONAB/6-30         AC H2NSL2.1
#=GS G3TS21_LOXAF/8-32         AC G3TS21.1
#=GS A0A3Q3GRI3_9LABR/13-34    AC A0A3Q3GRI3.1
#=GS M7CJF0_CHEMY/2-26         AC M7CJF0.1
#=GS A0A2R9A5M5_PANPA/6-30     AC A0A2R9A5M5.1
#=GS G3UK14_LOXAF/6-30         AC G3UK14.1
#=GS A0A3P9DU23_9CICH/9-28     AC A0A3P9DU23.1
#=GS G3UJ00_LOXAF/6-30         AC G3UJ00.1
#=GS A0A2K6LYR5_RHIBE/6-30     AC A0A2K6LYR5.1
#=GS A0A1U7Q2G4_MESAU/6-30     AC A0A1U7Q2G4.1
#=GS A0A3P9PCM6_POERE/1-25     AC A0A3P9PCM6.1
#=GS A0A340XF60_LIPVE/6-30     AC A0A340XF60.1
#=GS G1SEU0_RABIT/6-30         AC G1SEU0.1
#=GS P53_MESAU/6-30            AC Q00366.1
#=GS G3UHE5_LOXAF/6-30         AC G3UHE5.1
#=GS F7F8L3_MACMU/6-30         AC F7F8L3.1
#=GS A0A1S3EYG2_DIPOR/29-53    AC A0A1S3EYG2.1
#=GS G3UI57_LOXAF/6-30         AC G3UI57.1
#=GS C3XPU2_BRAFL/1-25         AC C3XPU2.1
#=GS A0A2K5RN46_CEBCA/6-30     AC A0A2K5RN46.1
#=GS A0A3B3WEM0_9TELE/1-25     AC A0A3B3WEM0.1
#=GS H2U135_TAKRU/29-52        AC H2U135.2
#=GS A0A3Q7Y5W2_URSAR/6-30     AC A0A3Q7Y5W2.1
#=GS A0A2K5RN56_CEBCA/6-30     AC A0A2K5RN56.1
#=GS A0A3Q2HE67_HORSE/6-30     AC A0A3Q2HE67.1
#=GS A0A158SIS7_MOUSE/6-30     AC A0A158SIS7.1
#=GS A0A2I3NCU7_PAPAN/6-30     AC A0A2I3NCU7.1
#=GS A0A3P9DU30_9CICH/29-50    AC A0A3P9DU30.1
#=GS P53_RAT/6-30              AC P10361.1
#=GS A0A452QA33_URSAM/6-30     AC A0A452QA33.1
#=GS A0A3P9DUC9_9CICH/11-32    AC A0A3P9DUC9.1
#=GS K1RC48_CRAGI/211-235      AC K1RC48.1
#=GS A0A1S2ZRH2_ERIEU/2-31     AC A0A1S2ZRH2.1
#=GS A0A2K5RN37_CEBCA/6-30     AC A0A2K5RN37.1
#=GS A0A2U9B0Y2_SCOMX/10-34    AC A0A2U9B0Y2.1
#=GS A0A2I3LC67_PAPAN/6-30     AC A0A2I3LC67.1
#=GS A0A2R9A2G9_PANPA/6-30     AC A0A2R9A2G9.1
#=GS A0A1U7U5H4_TARSY/6-29     AC A0A1U7U5H4.1
#=GS A0A2I3T5N8_PANTR/6-30     AC A0A2I3T5N8.1
#=GS Q9EQL0_RAT/6-30           AC Q9EQL0.1
#=GS A0A337SFG8_FELCA/109-133  AC A0A337SFG8.1
#=GS A0A2K6AAN3_MANLE/6-30     AC A0A2K6AAN3.1
#=GS I3N5N2_ICTTR/6-30         AC I3N5N2.1
#=GS A0A2K6QDJ5_RHIRO/6-30     AC A0A2K6QDJ5.1
#=GS I3LA53_PIG/6-30           AC I3LA53.2
#=GS A0A0P7YNA4_SCLFO/112-136  AC A0A0P7YNA4.1
#=GS G3UDE4_LOXAF/6-30         AC G3UDE4.1
#=GS A0A1S3II34_LINUN/26-50    AC A0A1S3II34.1
#=GS C0H8X1_SALSA/4-23         AC C0H8X1.1
#=GS A0A3B3RRX6_9TELE/3-27     AC A0A3B3RRX6.1
#=GS A0A455C1G1_PHYMC/6-30     AC A0A455C1G1.1
#=GS A0A087WZU8_HUMAN/6-30     AC A0A087WZU8.1
#=GS P53_FELCA/6-30            AC P41685.1
#=GS A0A401TBG1_CHIPU/107-128  AC A0A401TBG1.1
#=GS A0A2I2ZNQ9_GORGO/6-30     AC A0A2I2ZNQ9.1
#=GS A0A2K5F3V2_AOTNA/6-30     AC A0A2K5F3V2.1
#=GS A0A2I3GX68_NOMLE/6-30     AC A0A2I3GX68.1
#=GS A0A3P9D4G6_9CICH/9-32     AC A0A3P9D4G6.1
#=GS A0A3B5AW35_9TELE/10-34    AC A0A3B5AW35.1
#=GS F7A9M9_XENTR/5-29         AC F7A9M9.1
#=GS F7H4N6_CALJA/6-30         AC F7H4N6.2
#=GS P53_PIG/6-30              AC Q9TUB2.1
#=GS W5N8V4_LEPOC/3-27         AC W5N8V4.1
#=GS A0A2K5TIV2_FELCA/109-133  AC A0A2K5TIV2.1
#=GS A0A2T7PTD4_POMCA/8-30     AC A0A2T7PTD4.1
#=GS G3U6U6_LOXAF/6-30         AC G3U6U6.1
#=GS A0A3F2YPG3_XIPMA/9-28     AC A0A3F2YPG3.1
#=GS A0A1S3RGF1_SALSA/38-57    AC A0A1S3RGF1.1
#=GS G3Q6V4_GASAC/10-34        AC G3Q6V4.1
#=GS A0A2K6LYM8_RHIBE/6-30     AC A0A2K6LYM8.1
#=GS J3KP33_HUMAN/6-30         AC J3KP33.1
#=GS G3U6D1_LOXAF/6-30         AC G3U6D1.1
#=GS A0A3P9DSN1_9CICH/14-35    AC A0A3P9DSN1.1
A0A2I3HEB4_NOMLE/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A3Q1HGV2_9TELE/9-33                .......LQLSQNLPLSQDSFQELWQSVVTA-p...
G3R2U9_GORGO/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
W4XZV6_STRPU/15-39                   .......SQEMADLPLSQETFHALWATLQND-v...
A0A2Y9L4Q2_ENHLU/6-30                .......SELTIDPPLSQETFSELWNLLPENN....
P53_DELLE/6-30                       ......a-ELGVEPPLSQETFSDLWKLLPENN....
A0A1U8BI05_MESAU/6-30                .......SDLSIELPLSQETFSDLWKLLPPNN....
A0A2I3HA34_NOMLE/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A3B5AW66_9TELE/9-32                .......LQLSQNLPLSQDSFRELWESLIN--e...
H3B1Z4_LATCH/6-29                    .......SESGLE-PLSQESFADLWNLLPTS-m...
P53_CANLF/6-30                       .......SELNIDPPLSQETFSELWNLLPENN....
F7GNX0_CALJA/6-30                    .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A3P8T0X9_AMPPE/9-33                .......LQLSQNLPLSQDSFQELWQSVITA-d...
A0A2I3SYN1_PANTR/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2K6QDJ8_RHIRO/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
G1MEP6_AILME/6-30                    .......SELTIDPPLSQETFSELWNLLPENN....
A0A2I3N9A3_PAPAN/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
C3VC56_SHEEP/6-30                    ......a-ELGVEPPLSQETFSDLWNLLPENN....
A0A2Y9R5B9_TRIMA/6-30                .......SDLSTELPLSQETFSYLWELLPEK-p...
P53_MACFA/6-30                       .......SDPSIEPPLSQETFSDLWKLLPENN....
L7N1B2_MYOLU/7-31                    ......q-PEVMDPPLSQETFSDLWNLLHDND....
A0A2K5WMY7_MACFA/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A340XCN5_LIPVE/6-30                ......a-ELGVEPPLSQETFSDLWKLLPENN....
G3ULT4_LOXAF/6-30                    .......SDLSIELPLSQETFSYLGKLLSEK-l...
A0A2K6QDJ2_RHIRO/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K5JJA8_COLAP/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A3B4FI32_9CICH/9-32                .......LQLSQNLPFSQDSFKELWDQLPS--t...
L5JZ91_PTEAL/6-30                    .......SELNMEPPLSQETFSDLWKLLPQNN....
A0A3Q1AJT5_AMPOC/9-33                .......LQLSQNLPLSQDSFQELWQSVITA-d...
A0A2K5N3M9_CERAT/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K5RMZ8_CEBCA/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A2K5N3J8_CERAT/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K5WN49_MACFA/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A0G2KBB2_RAT/6-30                  .......SDMSIELPLSQETFSCLWKLLPPD-d...
A0A3Q3H0Q2_9LABR/12-34               .......-SLSQTLPLSQGSFHQLWNLMNE--h...
A0A3Q1AKW0_AMPOC/9-32                .......LQLSQNLPLSQDSFQELWQSLL---ne..
A0A2I3GF05_NOMLE/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
G3WS63_SARHA/4-31                    ......s-LSDLEPPLSQETFSDLWKLQWNN-lpdd
A0A2K6QDI9_RHIRO/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
E9PCY9_HUMAN/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2I3T645_PANTR/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2K5N3F4_CERAT/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A1D5RL03_MACMU/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K5JJ67_COLAP/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K6QDJ3_RHIRO/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K6LYN1_RHIBE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
F7A9U0_XENTR/5-29                    .......SETGMEPPLSQETFEDLWSLLPDP-l...
A0A3B3RR15_9TELE/78-102              ......e-QDSEALPLSQETFQELWNLIT---vpp.
P53_BOVIN/6-30                       ......a-ELNVEPPLSQETFSDLWNLLPENN....
A0A3B4VC63_SERDU/9-33                .....lh--LSQNLPLSQDSFRELWESLPEV-l...
A0A2K5JJ46_COLAP/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A3P8T2H3_AMPPE/9-32                .......LQLSQNLPLSQDSFQELWQSLL---ne..
A0A3Q1JCZ2_ANATE/9-32                ......l-QLSQNLNLSQDSFRELWETVVT--p...
H2QC53_PANTR/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A3B4VBM7_SERDU/9-32                .....lh--LSQNLPLSQDSFRELWESVVT--p...
A0A3B3VCW8_9TELE/1-25                .......METNFPLPLSQDTFHELWNTVVLST....
A0A2I3MD32_PAPAN/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
L9KM90_TUPCH/20-44                   .......SDLSVELPLSQETFSDLWSLLPG--qd..
A0A2I2YTF6_GORGO/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A0G2KB75_RAT/6-30                  .......SDMSIELPLSQETFSCLWKLLPPD-d...
A0A452G0A3_CAPHI/6-30                ......a-ELGVEPPLSQETFSDLWNLLPENN....
A0A2R9A5Q0_PANPA/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2U4C2U9_TURTR/6-30                ......a-ELGVEPPLSQETFSDLWKLLPENN....
A0A286XW13_CAVPO/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A096P2R8_PAPAN/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
G3T035_LOXAF/6-30                    .......SDLSTELPLSQETFSYLWELLPENP....
G1RF61_NOMLE/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2K6AAI4_MANLE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A340X8E6_LIPVE/6-30                ......a-ELGVEPPLSQETFSDLWKLLPENN....
A0A3B4X6D0_SERLL/9-32                .....lh--LSQNLPLSQDSFRELWESVVT--p...
A0A3Q7TIN0_VULVU/6-30                .......SELNIDPPLSQETFSELWNLLPENN....
G1U940_RABIT/1-25                    .......SVLSLEPPLSQETLSDLWKLLSEYN....
P53_CAVPO/6-30                       .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A1S3EYC1_DIPOR/29-53               .......SDLNIDLPLSHESFSDFWKLLPDD-s...
A0A060YN57_ONCMY/4-23                ......l-AENVSLPLSQESFEDLWKM-----....
A0A2R8MB56_CALJA/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A3B5Q9F8_XIPMA/13-34               ......n----LRLPLSQDTFCDLWNNVLLST....
W5N8V9_LEPOC/3-27                    ......d-PEPEGLPLSQESFQELWNMVA---vpp.
A0A3B4XB19_SERLL/9-32                .....lh--LSQNLPLSQDSFRELWESI----tdt.
A0A2U3Y5G3_LEPWE/6-30                .......SELTIDPPLSQETFSELWNLLPENN....
A0A2I3T303_PANTR/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A210QTK4_MIZYE/82-104              ......t---PSGPPMSQETFEYLWNTLGEVT....
A0A2K6SLC5_SAIBB/6-30                .......SDLSIEPPLSQETFSDLWKLQDPV-p...
H2U133_TAKRU/2-25                    .......EDEGFSLPLSQDTFQDLWENV----aap.
A0A452G0L9_CAPHI/6-25                ......a-ELGVEPPLSQETFSDLWNL-----....
G5B5D6_HETGA/6-30                    .......SDLSIEPPLSQETFSDLWKLLPENN....
I7HIK9_MOUSE/6-30                    .......SDISLELPLSQETFSGLWKLLPP--ed..
A0A3P9DU20_9CICH/7-27                ......y----FNLPFSQNSFKELWEQLP---vt..
A0A3P8ZCJ5_ESOLU/4-23                ......l-SENVSLPLSQESFEDLWNM-----....
H3CXQ0_TETNG/2-25                    .......EEETFSLPLSQDTFQDLWENV----aap.
A0A2R9A5P4_PANPA/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A3Q3WGI5_MOLML/3-25                .....gq---DLSLPLSQGSFQELWQNV----yls.
A0A2D0RBJ9_ICTPU/2-26                .......SELEMTLPLSQDNFEQLWSDVGSN-m...
P53_HUMAN/6-30                       .......SDPSVEPPLSQETFSDLWKLLPENN....
#=GR P53_HUMAN/6-30            SS    .......CXSTTSXSSSTCHHHHHHHTSSTSC....
A0A2K6AAJ8_MANLE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K5JJ56_COLAP/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A3Q3B4E6_KRYMA/6-29                ......d-QPVLELPLSQGSFSELWAG-----mvts
E9PFT5_HUMAN/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2Y9Q793_DELLE/6-30                ......a-ELGVEPPLSQETFSDLWKLLPENN....
A0A2U3VT95_ODORO/6-30                .......SELTIDPPLSQETFSELWNLLPENN....
A0A2K6QDI6_RHIRO/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K6QDH6_RHIRO/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A452GW06_9SAUR/13-34               .......LDPGLEPPLSQESFSDFWSMM----a...
K7G3P4_PELSI/5-29                    .......LDTGLDLPLSQESFSDLWKTLSP--la..
H0XGB0_OTOGA/6-30                    .......SDLTIEPPLSQETFSDLWKLLPENN....
Q80ZA1_MOUSE/9-33                    .......SDISLELPLSQETFSGLWKLLPP--ed..
P53_SHEEP/6-30                       ......a-ELGVEPPLSQETFSDLWNLLPENN....
A0A2K5DXG0_AOTNA/6-25                .......SDLSIKPPLSQETFSDLW-------il..
G3Q6V7_GASAC/10-32                   ......l-ALGQDLPDSQDSFAELWGNV----lt..
A0A2K6GZZ6_PROCO/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A2K6GZU4_PROCO/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
Q549C9_MOUSE/9-33                    .......SDISLELPLSQETFSGLWKLLPP--ed..
A0A3P9DTH1_9CICH/24-45               .....ee----LNLPFSQNSFKELWEQLP---vt..
A0A2I2ZTB3_GORGO/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2K5N3I9_CERAT/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A3Q4BCJ5_MOLML/9-30                .......-DTDLSLPLSQGSFQELWQNV----yv..
E7EQX7_HUMAN/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A3Q1JCZ8_ANATE/9-33                ......l-QLSQNLNLSQDSFRELWETLIND-q...
A0A1S3IK29_LINUN/32-56               ......g-NEGVNPPLSQETFDGLWDQLM---iqt.
F1PI27_CANLF/8-32                    .......SELNIDPPLSQETFSELWNLLPENN....
P53_MACMU/6-30                       .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K6LYP2_RHIBE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A384BVC2_URSMA/6-30                .......SELTIDPPLSQETFSELWNLLPENN....
M3YC88_MUSPF/6-30                    .......SELTIDPPLSQETFSELWNLLPENN....
G3UAZ0_LOXAF/6-30                    .......SDLSTELPLSQETFSYLGKLLPEK-l...
A0A2K5JJ89_COLAP/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K6LYM5_RHIBE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K6AAH4_MANLE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
V4A869_LOTGI/10-34                   ......g-NTNSQPPMSQDTFDFLWKTLGDAT....
A0A2I2ZK26_GORGO/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
I3KRX9_ORENI/9-33                    .......LQLSQNLPLSQDSFKELWDKIIPST....
A0A096MBY3_POEFO/4-28                .......METNFPLPLSQDTFHELWNTVVLST....
A0A3Q2W984_HAPBU/9-32                .......LQLSQNLPFSQDSFKELWDQLPV--a...
A0A3Q3WVD8_MOLML/3-24                .....gq---DLSLPLSQGSFQELWQNV----yv..
A0A2K6LYM9_RHIBE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2K6AAQ3_MANLE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
P53_XIPMA/2-26                       ......e-EADLTLPLSQDTFHDLWNNVFLST....
A0A087XP53_POEFO/1-25                .......METNFPLPLSQDTFHELWNTVVLST....
S4R334_HUMAN/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
F7GP14_CALJA/6-30                    .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A383YUA7_BALAS/6-30                ......a-ELGVEPPLSQESFSDLWKLLPENN....
P53_RABIT/6-30                       .......SDLSLEPPLSQETFSDLWKLLPENN....
A0A3P9DU35_9CICH/4-27                .....qt--LDTNLPFSQNSFKELWEQLP---vt..
E7EMR6_HUMAN/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2K6LYQ1_RHIBE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A0D9RG12_CHLSB/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A3Q4HSS6_NEOBR/9-32                .......LQLSQNLPFSQDSFKELWDQLP---vt..
A0A2K5WMM5_MACFA/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A452G156_CAPHI/6-30                ......a-ELGVEPPLSQETFSDLWNLLPENN....
A0A091CJU7_FUKDA/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
P53_MOUSE/9-33                       .......SDISLELPLSQETFSGLWKLLPP--ed..
H2NSL2_PONAB/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
G3TS21_LOXAF/8-32                    .......SDLSTELLLSQETFSYLGKLLPEK-l...
A0A3Q3GRI3_9LABR/13-34               .......-SLSQTLPLSQGSFHQLWNVL----td..
M7CJF0_CHEMY/2-26                    .......LDPGLEPPLSQESFSDWWSMMLQPT....
A0A2R9A5M5_PANPA/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
G3UK14_LOXAF/6-30                    .......SDLSTELPLSQETFSYLGKLLPEK-l...
A0A3P9DU23_9CICH/9-28                ......p-----NLPFSQNSFKELWEQLP---vt..
G3UJ00_LOXAF/6-30                    .......SDLSTELPLSQETFSYLGKLLPEK-l...
A0A2K6LYR5_RHIBE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A1U7Q2G4_MESAU/6-30                .......SDLSIELPLSQETFSDLWKLLPPNN....
A0A3P9PCM6_POERE/1-25                .......MDPDFNLPLSQDTFHDLWNTVVLST....
A0A340XF60_LIPVE/6-30                ......a-ELGVEPPLSQETFSDLWKLLPENN....
G1SEU0_RABIT/6-30                    .......SDLSLEPPLSQETFSDLWKLLPENN....
P53_MESAU/6-30                       .......SDLSIELPLSQETFSDLWKLLPPNN....
G3UHE5_LOXAF/6-30                    .......SDLSTELPLSQGTFSYLGKLLPEK-l...
F7F8L3_MACMU/6-30                    .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A1S3EYG2_DIPOR/29-53               .......SDLNIDLPLSHESFSDFWKLLPDD-s...
G3UI57_LOXAF/6-30                    .......SDLSTELPLSQETFSCLGKLLPEK-v...
C3XPU2_BRAFL/1-25                    .......MSQGSNPPLSQETFNQLWNQINSVT....
A0A2K5RN46_CEBCA/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A3B3WEM0_9TELE/1-25                .......METNFPLPLSQDTFHELWNTVVLST....
H2U135_TAKRU/29-52                   .......EDEGFSLPLSQDTFQDLWENV----aap.
A0A3Q7Y5W2_URSAR/6-30                .......SELTIDPPLSQETFSELWNLLPENN....
A0A2K5RN56_CEBCA/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A3Q2HE67_HORSE/6-30                ......t-ELGIEPPLSQETFSDLWKLLPENN....
A0A158SIS7_MOUSE/6-30                .......SDISLELPLSQETFSGLWKLLPP--ed..
A0A2I3NCU7_PAPAN/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A3P9DU30_9CICH/29-50               ......f---NQNLPFSQNSFKELWEQLP---vt..
P53_RAT/6-30                         .......SDMSIELPLSQETFSCLWKLLPPD-d...
A0A452QA33_URSAM/6-30                .......SELTIDPPLSQETFSELWNLLPENN....
A0A3P9DUC9_9CICH/11-32               ......f---NQNLPFSQNSFKELWEQLP---vt..
K1RC48_CRAGI/211-235                 .......SSSVTGPPLSQEAFDYLWHSLDACT....
A0A1S2ZRH2_ERIEU/2-31                medlple--LDVDTPLSQTTFSELWNLLPDK-d...
A0A2K5RN37_CEBCA/6-30                .......SDLSIEPPLSQETFSDLWKLQDPV-p...
A0A2U9B0Y2_SCOMX/10-34               .....lh--LSQTLPLSQDSFMELWDNVLSY-d...
A0A2I3LC67_PAPAN/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
A0A2R9A2G9_PANPA/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A1U7U5H4_TARSY/6-29                .......SDLSIE-PLSQETFSDLWKLLPENN....
A0A2I3T5N8_PANTR/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
Q9EQL0_RAT/6-30                      .......SDMSIELPLSQETFSCLWKLLPPD-d...
A0A337SFG8_FELCA/109-133             .......LELTIEPPLSQETFSELWNLLPENN....
A0A2K6AAN3_MANLE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
I3N5N2_ICTTR/6-30                    .......SDLSIEPPLSQETFSDLWNLLPENN....
A0A2K6QDJ5_RHIRO/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
I3LA53_PIG/6-30                      .......SELGVEPPLSQETFSDLWKLV----esqp
A0A0P7YNA4_SCLFO/112-136             .......EEDMPSLPFSQESFQELWKDLMPAP....
G3UDE4_LOXAF/6-30                    .......SDLSTELPLSQETFSYLGKLLPEK-l...
A0A1S3II34_LINUN/26-50               ......g-NEGVNPPLSQETFDGLWDQLM---iqt.
C0H8X1_SALSA/4-23                    ......l-VENVSLPLSQESFEDLWKM-----....
A0A3B3RRX6_9TELE/3-27                ......e-QDSEALPLSQETFQELWNLIT---vpp.
A0A455C1G1_PHYMC/6-30                ......a-ELGVEPPLSQETFSDLWKLLPENN....
A0A087WZU8_HUMAN/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
P53_FELCA/6-30                       .......LELTIEPPLSQETFSELWNLLPENN....
A0A401TBG1_CHIPU/107-128             ..sqlde-------PLSQETFRELWNQL----evp.
A0A2I2ZNQ9_GORGO/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A2K5F3V2_AOTNA/6-30                .......SDLSIEPPLSQETFSDLWKLLPENN....
A0A2I3GX68_NOMLE/6-30                .......SDPSVEPPLSQETFSDLWKLLPENN....
A0A3P9D4G6_9CICH/9-32                .......LQLSQNLPFSQDSFKELWDQLPV--a...
A0A3B5AW35_9TELE/10-34               .......LQLSQNLPLSQDSFRELWESVVAA-p...
F7A9M9_XENTR/5-29                    .......SETGMEPPLSQETFEDLWSLLPDP-l...
F7H4N6_CALJA/6-30                    .......SDLSIEPPLSQETFSDLWKLLPENN....
P53_PIG/6-30                         .......SELGVEPPLSQETFSDLWKLLPENN....
W5N8V4_LEPOC/3-27                    ......d-PEPEGLPLSQESFQELWNMVIV--lh..
A0A2K5TIV2_FELCA/109-133             .......LELTIEPPLSQETFSELWNLLPENN....
A0A2T7PTD4_POMCA/8-30                sctppnl--------MSQDTFQTLWDSLGE--i...
G3U6U6_LOXAF/6-30                    .......SDLSTELPLSQGTFSYLGKLLPEK-l...
A0A3F2YPG3_XIPMA/9-28                ......e-EADLTLPLSQDTFHDLWNN-----....
A0A1S3RGF1_SALSA/38-57               ......l-VENVSLPLSQESFEDLWKM-----....
G3Q6V4_GASAC/10-34                   ......l-ALGQDLPDSQDSFAELWGNVVSPP....
A0A2K6LYM8_RHIBE/6-30                .......SDPSIEPPLSQETFSDLWKLLPENN....
J3KP33_HUMAN/6-30                    .......SDPSVEPPLSQETFSDLWKLLPENN....
G3U6D1_LOXAF/6-30                    .......SDLSTELPLSQGTFSYLGKLLPEK-l...
A0A3P9DSN1_9CICH/14-35               ......f---NQNLPFSQNSFKELWEQLP---vt..
#=GC SS_cons                         .......CXSTTSXSSSTCHHHHHHHTSSTSC....
#=GC seq_cons                        .......S-.SlEPPLSQETFSDLWcLLP-ss....
//
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