GenomeNet

Database: Pfam
Entry: PBP1_TM
LinkDB: PBP1_TM
Original site: PBP1_TM 
#=GF ID   PBP1_TM
#=GF AC   PF14812.7
#=GF DE   Transmembrane domain of transglycosylase PBP1 at N-terminal
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   CATH:3fwl_A_01, Pfam-B_367 (release 26.0)
#=GF GA   27.80 27.80;
#=GF TC   27.80 28.30;
#=GF NC   27.60 27.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   19458048
#=GF RT   Crystal structure of the membrane-bound bifunctional
#=GF RT   transglycosylase PBP1b from  Escherichia coli.
#=GF RA   Sung MT, Lai YT, Huang CY, Chou LY, Shih HW, Cheng WC, Wong CH,
#=GF RA   Ma C;
#=GF RL   Proc Natl Acad Sci U S A. 2009;106:8824-8829.
#=GF DR   INTERPRO; IPR032730;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is the N-terminal, transmembrane, domain of the
#=GF CC   transglycosylases ()penicillin-binding proteins), the
#=GF CC   multi-domain membrane proteins essential for cell wall synthesis
#=GF CC   that are targeted by penicillin antibiotics. The TM domain is a
#=GF CC   single helix, several of whose residues lie in close proximity
#=GF CC   to hydrophobic residues in the TGT domain. The TM helix seems to
#=GF CC   be necessary for stabilizing the protein-membrane interaction,
#=GF CC   and the resulting orientation limits the interaction between
#=GF CC   PBPb1 and lipid II in the membrane in a 2D lateral diffusion
#=GF CC   fashion [1].
#=GF SQ   113
#=GS W0I1G7_9GAMM/1-83         AC W0I1G7.1
#=GS A0A140NLP5_PROSM/2-35     AC A0A140NLP5.1
#=GS A0A097R5N0_HAFAL/1-96     AC A0A097R5N0.1
#=GS Q8ZRQ3_SALTY/1-74         AC Q8ZRQ3.1
#=GS A0A2X4TLC6_SALER/1-52     AC A0A2X4TLC6.1
#=GS A0A2I0FVL5_9GAMM/1-78     AC A0A2I0FVL5.1
#=GS C5BH79_EDWI9/1-87         AC C5BH79.1
#=GS B2VCM2_ERWT9/4-82         AC B2VCM2.1
#=GS A8ALE0_CITK8/1-78         AC A8ALE0.1
#=GS A0A1W6B204_9GAMM/1-76     AC A0A1W6B204.1
#=GS D4GKB2_PANAM/1-78         AC D4GKB2.1
#=GS A0A378C0Q6_KLEPO/1-32     AC A0A378C0Q6.1
#=GS A0A0H3GIH5_KLEPH/1-79     AC A0A0H3GIH5.1
#=GS A0A384LBB8_YERPE/1-82     AC A0A384LBB8.1
#=GS A0A0M2KDQ3_9GAMM/1-76     AC A0A0M2KDQ3.1
#=GS A0A0H5MBM7_YERIN/1-87     AC A0A0H5MBM7.1
#=GS A0A366I851_9GAMM/1-81     AC A0A366I851.1
#=GS A0A1B7JMM2_9GAMM/1-93     AC A0A1B7JMM2.1
#=GS G7LSA1_9GAMM/1-85         AC G7LSA1.1
#=GS V9H7N6_9CLOT/292-363      AC V9H7N6.1
#=GS A6T4V3_KLEP7/1-79         AC A6T4V3.1
#=GS H2IQ93_RAHAC/1-95         AC H2IQ93.1
#=GS A0A3R8Z2R4_9GAMM/1-76     AC A0A3R8Z2R4.1
#=GS A0A1I4WTN8_9ENTR/1-73     AC A0A1I4WTN8.1
#=GS D2TI37_CITRI/1-78         AC D2TI37.1
#=GS PBPB_ECOLI/1-79           AC P02919.2
#=GS PBPB_ECOLI/1-79           DR PDB; 5FGZ A; 72-79;
#=GS PBPB_ECOLI/1-79           DR PDB; 5HL9 A; 68-79;
#=GS PBPB_ECOLI/1-79           DR PDB; 3FWL A; 66-79;
#=GS PBPB_ECOLI/1-79           DR PDB; 5HLB A; 67-79;
#=GS PBPB_ECOLI/1-79           DR PDB; 5HLD A; 73-79;
#=GS PBPB_ECOLI/1-79           DR PDB; 5HLA A; 67-79;
#=GS PBPB_ECOLI/1-79           DR PDB; 3VMA A; 72-79;
#=GS A0A2S9I4K4_9GAMM/1-79     AC A0A2S9I4K4.1
#=GS A0A2S4MSR0_SHIFL/1-79     AC A0A2S4MSR0.1
#=GS A0A257LXW1_9BACT/11-92    AC A0A257LXW1.1
#=GS A0A2U4E269_CITAM/1-78     AC A0A2U4E269.1
#=GS A0A084A612_9GAMM/45-99    AC A0A084A612.1
#=GS A0A085JJP5_9GAMM/1-77     AC A0A085JJP5.1
#=GS W1EQT8_KLEPN/1-79         AC W1EQT8.1
#=GS A0A0Q4M663_9GAMM/1-98     AC A0A0Q4M663.1
#=GS A0A0J8YQU7_9GAMM/1-80     AC A0A0J8YQU7.1
#=GS D3V553_XENBS/1-81         AC D3V553.1
#=GS D8MNB6_ERWBE/1-80         AC D8MNB6.1
#=GS A0A0V9JN88_9ENTR/1-78     AC A0A0V9JN88.1
#=GS A0A0Q4MV86_9GAMM/1-78     AC A0A0Q4MV86.1
#=GS Q2NVQ6_SODGM/1-80         AC Q2NVQ6.1
#=GS A0A2I5T5M1_SERS3/1-86     AC A0A2I5T5M1.1
#=GS A0A250B3A8_9ENTR/1-85     AC A0A250B3A8.1
#=GS Q32JV9_SHIDS/1-79         AC Q32JV9.1
#=GS A0A2X5ABQ0_SERRU/1-86     AC A0A2X5ABQ0.1
#=GS S3JL07_9ENTR/1-83         AC S3JL07.1
#=GS D3VL04_XENNA/1-86         AC D3VL04.1
#=GS A0A090UZ74_ESCVU/1-79     AC A0A090UZ74.1
#=GS W0LAW6_9GAMM/1-86         AC W0LAW6.1
#=GS A0A0J5LVU0_PLUGE/1-79     AC A0A0J5LVU0.1
#=GS A0A0L7SZB5_9GAMM/1-82     AC A0A0L7SZB5.1
#=GS A0A2X3E990_KLUCR/1-79     AC A0A2X3E990.1
#=GS H5V4C9_ATLHE/1-76         AC H5V4C9.1
#=GS A0A085GJ62_9ENTR/10-90    AC A0A085GJ62.1
#=GS A0A2A2GQ98_9GAMM/1-80     AC A0A2A2GQ98.1
#=GS Q7N862_PHOLL/1-79         AC Q7N862.1
#=GS C7BMS0_PHOAA/6-87         AC C7BMS0.1
#=GS A0A2P8VHI8_9ENTR/1-81     AC A0A2P8VHI8.1
#=GS A0A085ABN8_9ENTR/1-79     AC A0A085ABN8.1
#=GS A0A1C3Z9J0_9ENTR/1-78     AC A0A1C3Z9J0.1
#=GS A0A0J8YWE8_9GAMM/1-78     AC A0A0J8YWE8.1
#=GS A0A0J8VNI1_9ENTR/1-81     AC A0A0J8VNI1.1
#=GS A9MPL2_SALAR/1-74         AC A9MPL2.1
#=GS A0A370QPV3_9ENTR/2-53     AC A0A370QPV3.1
#=GS W0HML6_9GAMM/1-74         AC W0HML6.1
#=GS Q8X903_ECO57/1-79         AC Q8X903.1
#=GS A0A068QZ33_9GAMM/1-84     AC A0A068QZ33.1
#=GS U2LMK6_SERFO/1-85         AC U2LMK6.1
#=GS E3G929_ENTLS/1-78         AC E3G929.1
#=GS A0A0L0AFX2_9ENTR/1-77     AC A0A0L0AFX2.1
#=GS D4E1W8_SEROD/1-86         AC D4E1W8.1
#=GS A0A084A612_9GAMM/1-50     AC A0A084A612.1
#=GS A0A2D0KKD1_9GAMM/1-85     AC A0A2D0KKD1.1
#=GS E0SBK6_DICD3/1-81         AC E0SBK6.1
#=GS L0MAA6_ENTBF/1-79         AC L0MAA6.1
#=GS Q6D1Y4_PECAS/1-81         AC Q6D1Y4.1
#=GS A0A318WGR8_9ENTR/1-77     AC A0A318WGR8.1
#=GS A0A2G0Q475_9GAMM/1-78     AC A0A2G0Q475.1
#=GS A0A370QPV3_9ENTR/50-100   AC A0A370QPV3.1
#=GS W1GM52_KLEPN/1-79         AC W1GM52.1
#=GS T0QJE5_PHOTE/1-83         AC T0QJE5.1
#=GS A0A495AIM7_9ENTR/1-80     AC A0A495AIM7.1
#=GS A0A2N5EKD4_9GAMM/1-88     AC A0A2N5EKD4.1
#=GS A0A417PSE7_9CLOT/284-368  AC A0A417PSE7.1
#=GS A0A085GNS5_9GAMM/1-102    AC A0A085GNS5.1
#=GS A0A0T9LNE3_9GAMM/1-85     AC A0A0T9LNE3.1
#=GS A0A2V1HAJ6_9GAMM/1-93     AC A0A2V1HAJ6.1
#=GS A0A443I8W1_9GAMM/1-83     AC A0A443I8W1.1
#=GS A0A0G4JX91_9GAMM/1-82     AC A0A0G4JX91.1
#=GS A0A1U6ID04_9ENTR/1-78     AC A0A1U6ID04.1
#=GS A0A2X2E2Y6_RAOPL/1-79     AC A0A2X2E2Y6.1
#=GS A0A3N1ISS2_9ENTR/1-78     AC A0A3N1ISS2.1
#=GS D1P4I5_9GAMM/1-88         AC D1P4I5.1
#=GS A0A2P5IVI4_9GAMM/1-79     AC A0A2P5IVI4.1
#=GS A0A1H4EB36_9GAMM/1-76     AC A0A1H4EB36.1
#=GS A0A378EB75_KLEPR/1-76     AC A0A378EB75.1
#=GS A0A0N0Z8D3_9GAMM/1-88     AC A0A0N0Z8D3.1
#=GS A0A240CCL5_SERFI/1-82     AC A0A240CCL5.1
#=GS J7SKR5_MORMO/1-94         AC J7SKR5.1
#=GS K8W302_9GAMM/1-95         AC K8W302.1
#=GS U3TMS9_9ENTR/1-80         AC U3TMS9.1
#=GS A4W6P6_ENT38/1-78         AC A4W6P6.1
#=GS W1FUK4_ECOLX/1-78         AC W1FUK4.1
#=GS W1DUE4_KLEPN/1-79         AC W1DUE4.1
#=GS A0A1T4NMR7_ENTAG/1-78     AC A0A1T4NMR7.1
#=GS E9CN74_9GAMM/1-75         AC E9CN74.1
#=GS A0A0U5KZP4_9GAMM/1-79     AC A0A0U5KZP4.1
#=GS A0A071LWQ4_9ENTR/1-84     AC A0A071LWQ4.1
#=GS A0A095V6S1_9GAMM/1-77     AC A0A095V6S1.1
#=GS A0A014N8J2_9GAMM/1-76     AC A0A014N8J2.1
#=GS A0A2G8E8T3_9GAMM/1-76     AC A0A2G8E8T3.1
#=GS I2BCM2_SHIBC/1-89         AC I2BCM2.1
#=GS W1I1F0_KLEPN/1-79         AC W1I1F0.1
#=GS W1J9U1_9GAMM/1-82         AC W1J9U1.1
W0I1G7_9GAMM/1-83                    .........MSGDD.REPIGRHGRPS..GRKA..PRKAA.P.R-RRR....DDDYDD...........--..DDRWQ...DDD....DD...D....E....EEYVm....pPRK.........GR...G.G.A-P..RKK.RR.....L.LGW.VIRLVLLFVVV......
A0A140NLP5_PROSM/2-35                .....aknk-----.-----------..----..-----.-.-----....------...........--..-----...---....--...-....-....----......NNK.........GN...K.N.RKP..KSR.WR.....W.FWL.LVKIFIVFAVL......
A0A097R5N0_HAFAL/1-96                ......msr--DDD.REPIGRKGKKG..GTPP..SRKAV.P.NRRRRyddeDDDYRD...........DF..RDTAD...DHD....DY...E....E....DDDY......DDEdre...ddvAR...K.K.VKK..SRK.RK.....L.LGL.LIKLALIVFVL......
Q8ZRQ3_SALTY/1-74                    .........MAGND.REPIGRKGKPS..--RP..VKQKV.S.RRRQH....DDDYDD...........--..-----...---....DY...E....D....EEPM......PRK.........GK...GkG.RKP..RGK.RG.....W.LWL.LLKLFIVFVVL......
A0A2X4TLC6_SALER/1-52                .........MAGND.REPIGRKGKPS..--RP..VKQKV.S.RRRQH....DDDYDD...........--..-----...---....DY...E....D....EEPM......PRK.........GK...G.Q.R--..---.--.....-.---.-----------a.....
A0A2I0FVL5_9GAMM/1-78                .........MSGND.REPIGRKGKAP..--TP..PRKNA.V.KGRRR....DDDYDD...........--..--EYQ...DDD....DD...E....E....DVVM......PRN.........GK...K.G.T-P..RKK.RR.....W.LGL.FIKLMLVFVVL......
C5BH79_EDWI9/1-87                    .........MSGDD.RQPIGRKGKKR..AAQP..LRGEP.T.RRRRRy..dEDDYDEd.........dQE..RGESD...DDG...yDD...D....D....EGDV......AHK.........QV...K.R.---..SRR.RR.....V.LWL.LFRLALVALVV......
B2VCM2_ERWT9/4-82                    .........MS-DD.REPIGRKGKQP..--QP..PRNKA.G.RGRRR....EPQYDD...........-Y..DDQDH...DL-....DD...E....E....ITPV......PRK.........-A...K.A.RPA..RKK.RG.....W.LGL.FIKLFLVFVV-a.....
A8ALE0_CITK8/1-78                    .........MAGND.REPIGRKGKPP..--RP..VKQKV.S.RRRLR....DEEYDD...........--..--DYD...D--....DY...E....D....EEPM......PRN.........GK...GkG.RKP..RGK.RG.....W.LWL.LLKLSIVFVVL......
A0A1W6B204_9GAMM/1-76                .........MSGND.REPIGRKGKQP..--KP..PRQSG.G.PGRRR....E-EYND...........--..----E...EHD....DY...Q....E....ERPV......PRK.........GK...G.R.PPR..SKK.RK.....W.LGW.LIKLFIVFVVV......
D4GKB2_PANAM/1-78                    .........MSGND.REPIGRKGKPL..---P..PRSSA.R.RGRRR....DID--D...........--..-DAQD...DFD...dDY...E....E....EAPV......PRK.........GK...G.G.KPP..RGK.RR.....W.LGW.LIKLFLVFVVV......
A0A378C0Q6_KLEPO/1-32                .........-----.-----------..----..-----.-.-----....------...........--..-----...---....--...-....-....---M......PRKa.......kGK...G.G.K-P..RRK.RS.....W.LWL.LVKLGIVFAVL......
A0A0H3GIH5_KLEPH/1-79                .........MAGDD.REPIGRKGRPS..--RP..TKQKV.T.RRRVR....EEDYDD...........--..--EYD...D-D....DY...E....D....EKPV......PRKa.......kGK...G.G.K-P..RRK.RS.....W.LWL.LVKLGIVFAVL......
A0A384LBB8_YERPE/1-82                .........MSGDD.REPIGRKGKKA..QPKA..APKRP.L.RRRRD....EDEYEE...........DY..DEEQN...DY-....-D...D....E....EEPM......PRK.........-V...A.S.RPP..RKK.RR.....W.LGL.LIKLFLIGAV-a.....
A0A0M2KDQ3_9GAMM/1-76                .........MS-DD.REPIGRKGKKP..--NP..PRSPA.G.RGKRR....DDD-E-...........--..-DFQD...DDH....DN...E....E....RQSV......PRN.........GK...G.R.S-P..RRR.RG.....W.LGL.FVKPALVFILV......
A0A0H5MBM7_YERIN/1-87                .........MSGDD.REPIGRKGKKA..QPKA..APKRP.L.RRRRD....EDEYEE...........DYldDDDHD...DDD...yDD...D....E....EEPM......PRK.........-V...A.S.RPP..RKK.RR.....W.LGL.LIKLFLVGAVV......
A0A366I851_9GAMM/1-81                .........MSRDD.REPIGRKGRAS..GRKP..TRRQA.I.R-RHR....DDDYDD...........DY..EDDQD...DFN....DDdryD....D....EDSM......TQK.........--...-.-.--P..RKK.RR.....W.LGL.FIKLSLVFAVV......
A0A1B7JMM2_9GAMM/1-93                .........MSGKDnNEPIGRRSKKA..AE--..KKQSS.S.RRRRD....RDDYDDedl....leddDI..DDQYL...DD-....EE...D....E....EEQM......AKKg......skNK...K.T.RKV..KSK.WR.....W.FWL.LVKLMVVFAVL......
G7LSA1_9GAMM/1-85                    .........MSRDD.REPIGRKGKAS..GRKP..ARKQA.V.R-RRR....DDDYDD...........DY..EDDYD...DYQ....DD...Y....D....DDGY.....dDEG.........GM...T.R.KSR..NKR.RS.....W.LGL.FIKLFLVFAVL......
V9H7N6_9CLOT/292-363                 ....tpint-----.-----------..----..QNQKT.N.HSSKL....EDDYDEe.........dDY..DEDED..fDDD....YD...E....D....EDEL......PKK.........KK...S.K.NGV..KKA.IV.....T.IGV.IIGVIIL----gsv...
A6T4V3_KLEP7/1-79                    .........MAGDD.REPIGRKGRPS..--RP..TKQKV.T.RRRVR....EEDYDD...........--..--EYD...D-D....DY...E....D....EKPV......PRKa.......kGK...G.G.K-P..RRK.RS.....W.LWL.LVKLGIVFAVL......
H2IQ93_RAHAC/1-95                    .........MSGDD.REPIGRKGKPA..GRKP..ARARP.V.RRSRR....DDDYEEy........eeEI..DDEYE...DDD....DY...E....E....ERESr....mSRKapp...rkaNK...G.G.K-K..SKK.RR.....L.FWL.LVKLFVVFLIL......
A0A3R8Z2R4_9GAMM/1-76                .........MS-DD.REPIGRKGKQP..--NP..PRKTA.G.RGRRR....DVDNI-...........--..-DFQD...DDH....NN...E....E....KVPV......PRK.........GK...G.R.P--..PRK.RG.....W.LSL.MIKLLLVFIVL......
A0A1I4WTN8_9ENTR/1-73                .........MSGND.REPIGRKGKQP..--KP..PRSRV.R.WGRRK....EEDYAD...........--..-----...--D....DD...E....E....VTFV......PRK.........GK...G.G.P-R..GGK.RR.....W.LGL.FIKLFLLLIVI......
D2TI37_CITRI/1-78                    .........MAGND.REPIGRKGKPS..--RP..VKQKV.S.RRQLR....DDEYDD...........--..--EYD...D--....DY...E....D....EEPM......PRK.........GK...GkG.RKP..RGK.RG.....W.LWL.LLKIAIVFLVL......
PBPB_ECOLI/1-79                      .........MAGND.REPIGRKGKPT..--RP..VKQKV.S.R-RRY....EDD---...........--..-DDYD...DYD....DY...E....D....EEPM......PRK.........GKgkgK.G.RKP..RGK.RG.....W.LWL.LLKLAIVFAVL......
#=GR PBPB_ECOLI/1-79           SS    .........XXXXX.XXXXXXXXXXX..--XX..XXXXX.X.X-XXX....XXX---...........--..-XXXX...XXX....XX...X....X....XXXX......XXX.........XXXXXX.X.XXX..XXX.XX.....X.XXX.THHHHHHHHHH......
A0A2S9I4K4_9GAMM/1-79                .........MS-DD.REPIGRKGKQP..--KP..TRKSA.G.KGRYR....EEEYDE...........-Y..D-DQD...DDQ....ED...E....E....VTPV......SRK.........GK...G.K.P-P..RKK.RR.....W.LRL.LLKLLVIFIV-a.....
A0A2S4MSR0_SHIFL/1-79                .........MAGND.REPIGRKGKPT..--RP..VKQKV.S.R-RRY....EDD---...........--..-DDYD...DYD....DY...E....D....EEPM......PRK.........GKgkgK.G.RKP..RGK.RG.....W.LWL.LLKLAIVFAVL......
A0A257LXW1_9BACT/11-92               .......cg----D.EVPIGPRGCPK..CTKPpkPRKKA.Q.RPSWE....QDKYLD...........DL..DLPNE...DFD....YD...-....-....-EFV......ARE........fGK...K.P.H-R..KIG.IK.....W.YWW.VTALVLLVLII......
A0A2U4E269_CITAM/1-78                .........MAGND.REPIGRKGKTT..--RP..VKQKV.S.RRQLR....DDEYDD...........--..--EYD...D--....DY...E....D....EEPM......PRK.........GK...GkG.RKP..RGK.RG.....W.LWL.LLKIAIVFAVL......
A0A084A612_9GAMM/45-99               .......ye-----.-----------..----..-----.-.-----....ENEYQD...........EY..DDDED...GYD....EE...Y....E....EKRM......SRK.........-V...K.A.RPS..RKK.RR.....W.LGL.LIKLFLVVAA-l.....
A0A085JJP5_9GAMM/1-77                .........MSGND.REPIGRKGKTP..-RQP..EKKRP.R.AKSKN....SKAYDD...........--..----H...EMS....GY...E....E....EVAL......SRK.........GK...K.K.P-P..MKK.RR.....W.LGW.LIKLFLLGAIV......
W1EQT8_KLEPN/1-79                    .........MAGDD.REPIGRKGRPS..--RP..TKQKV.T.RRRVR....EEDYDD...........--..--EYD...D-D....DY...E....D....EKPV......PRKa.......kGK...G.G.K-P..RRK.RS.....W.LWL.LVKLGIVFAVL......
A0A0Q4M663_9GAMM/1-98                .........MSGDD.REPIGRKGKPS..PPKP..KRGRP.D.R-RSR....DDDEDSry.......vyQG..NDEQE...DDD....DS...RkaapQ....ESRM......TRKtak...sgkGA...T.S.KKP..RKK.RR.....W.LGL.LIKLFIIFVVL......
A0A0J8YQU7_9GAMM/1-80                .........MS-DD.REPIGRKGKQP..--KP..PRNKA.G.RGRRR...eEEEYDE...........-Y..DDQ-D...DDL....DD...E....E....VTPV......PRK.........GK...G.R.S-P..RKK.RG.....W.IGL.LIKLFLLFAVV......
D3V553_XENBS/1-81                    .........MSDDD.RQPIGRKGKKP..ELR-..-RERP.A.KKRHR....QDDYEN...........--..-DENN...DFD....ND...D....E....EQVM......TKK.........GK...K.P.RPP..RSR.WR.....G.FWLlLLKIFIVLAVL......
D8MNB6_ERWBE/1-80                    .........MS-DD.REPIGRKGKQP..--KP..PRKVA.G.KGRRR....DDEHDD...........-Y..DDFQD...DDH....EN...E....E....VEPV......PRK.........GK...G.R.P-P..GKK.RG.....W.LSL.LIKLLLVFIVV......
A0A0V9JN88_9ENTR/1-78                .........MAGND.REPIGRKGKPS..--RP..VKQKV.S.RRQLR....DDEYDD...........--..--DYD...D--....DY...E....D....EKPM......PRK.........GK...GkG.RKP..RGK.RG.....W.LWL.LLKIAIVFLVL......
A0A0Q4MV86_9GAMM/1-78                .........MS-DD.REPIGRKGKQP..--KP..PRSTA.G.RGRRR....EDE-DD...........--..-YDR-...DDE....QE...E....E....VTPV......PRK.........GK...G.KgSTP..RKR.RG.....W.FWL.LVKLLVIFAVL......
Q2NVQ6_SODGM/1-80                    .........MSGDD.REPIGRHGRPS..GRKA..PRKAA.P.R-RRR....DDDYDD...........--..--RWQ...DDD....ED...E....E....EYLM.....pPRK.........GR...G.G.A-P..RKK.RR.....L.LSW.LISILLLLVVV......
A0A2I5T5M1_SERS3/1-86                .........MSRDD.REPIGRKGNTS..RRKP..TRKQT.V.R-RHR....DDDYDD...........DY..DEYDD...DYD...nDD...D....G....DGDG......DDN.........GK...NmT.RKP..RKK.RR.....W.LGL.MIKLSLIFAVV......
A0A250B3A8_9ENTR/1-85                .........MAGDD.REPIGRKGKQP..KRS-..TPRRP.L.RGRRD...dYDDYEE..........dEY..QDEYD...DDE....KD...D....E....EAPM......SRK.........VK...A.-.APP..RKK.RR.....W.LGL.IIKLLLVIAVL......
Q32JV9_SHIDS/1-79                    .........MVGND.REPIGRKGKPT..--RP..VKQKV.S.R-RRY....EDD---...........--..-DDYD...DYD....DY...E....D....EEPM......PRK.........GKgkdK.G.RKP..RGK.RG.....W.LWL.LLKLAIVFAVL......
A0A2X5ABQ0_SERRU/1-86                .........MAGDD.REPIGRKGKPP..KRS-..APRRP.P.RRRLD....DDD-DDyq.......anNF..QDEYD...DDE....YN...D....E....EERM......PRK.........VK...A.-.APP..RKK.RR.....W.LGL.MLKIILVLAVL......
S3JL07_9ENTR/1-83                    .........MAGND.REPIGRKGKAT..--RP..AKEKV.S.RRQVR....DEDYDD...........--..--DYE...DD-....DY...E....D....EEPM.....pPRKgk.....gkGK...G.S.GRP..SKK.RR.....F.FWL.LVKLAIIFTI-a.....
D3VL04_XENNA/1-86                    .........MSDDD.RQPIGRKGKKS..GLR-..-RGRA.S.KNRVR....QDDYDD...........--..-YEND...DFD....DD...D....E....DEVM......TKK.........GK...N.A.RSP..KSR.SSknrgnWiLWF.LLKVFIVLAVI......
A0A090UZ74_ESCVU/1-79                .........MAGND.REPIGRKGRPA..--RP..VKEKV.S.RRRLR....DEEMDD...........--..-----...--A....YD...E....D....DAPA......PRRgkg...ggnG-...K.G.KGG..KRK.RG.....W.FWL.LLKIFIVLLVL......
W0LAW6_9GAMM/1-86                    .........MAGDD.REPIGRKGKQA..KRN-..APRKP.V.R-RRR....EDDYDDye.......ddDY..QDEYD...DDE....YD...D....E....EEPV......PRK.........VK...A.R.-SP..RKK.RR.....W.LGL.MIKLFLVVAV-a.....
A0A0J5LVU0_PLUGE/1-79                .........MAGND.REPIGRKGKKP..-ARP..AKQKV.S.RRRLR....DDEYDD...........EY..--EYD...D--....--...E....D....DAPM......PRK.........GK...G.KgNRP..RGK.RG.....W.FWL.LVKLGIVFAVL......
A0A0L7SZB5_9GAMM/1-82                .........MSGND.REPIGRKGKQP..--KP..P-RKP.A.KGRRR....EEDYNE...........DY..DDYQD...DTD...dDH...E....E....TEPV......PRK.........AK...G.R.S-P..RKK.RG.....W.LGL.IIKLLLVVIVL......
A0A2X3E990_KLUCR/1-79                .........MAGND.REPIGRKGKPA..--RP..AKQKV.S.RRQLR....DDEYDD...........--..--DYD...D-D....DY...E....D....EKPR......SRKg.......gGK...G.G.K-P..RGK.HR.....W.FWF.LLKLGIVFAVL......
H5V4C9_ATLHE/1-76                    .........MAGND.REPIGRKGKPS..--RP..VKQKV.T.RRRLR....EDEYDD...........--..-----...DYE....DD...D....N....EEPM.....pPRK.........GK...G.K.K-P..QRK.RR.....W.LWL.LLKLMLVLIVV......
A0A085GJ62_9ENTR/10-90               .........MAGND.REPIGRKGKPS..--RP..AKEKV.S.RRRVR....EEEYDA...........--..--DYD...D--....DY...D....D....EEPM.....pPRK.........GKgsgN.G.RPP..RKK.RR.....W.LWF.LVKLFVVFVVL......
A0A2A2GQ98_9GAMM/1-80                .....mydk---DN.YEPIGRRSKKK..PTG-..-KKSK.S.HQNNR....LDNYD-...........--..-YEYE...DID....DN...E....E....EELM......ASK.........DN...K.S.RPP..KDR.WR.....W.FWL.FVKIAIVLAL-l.....
Q7N862_PHOLL/1-79                    .........MSGED.RQPIGRKGKKW..VS--..RRKRS.I.KRRYL....LDD-DN...........--..--GYE...DED...yDD...E....E....DQLM......TKK.........GM...Y.S.RPP..KKK.WR.....W.FWL.LFKIFIIFAVL......
C7BMS0_PHOAA/6-87                    .........MSGED.RQPIGRKGKKS..VSR-..-RKPP.SlRRRHL....LDDYDD...........--..GYEED...GDY....DD...E....E....DQPM......TKK.........GK...N.A.RPP..KKK.WR.....W.FWL.LFKIFIVFAVL......
A0A2P8VHI8_9ENTR/1-81                .........MAGND.REPIGRKGKPA..--RP..AKQKV.S.RRQLR....DDERDD...........DY..--EN-...--D....DY...D....D....GEPM......PRKv.......kGK...G.R.KSG..KGKgRK.....W.LWL.LLKLFIVFVVL......
A0A085ABN8_9ENTR/1-79                .........MAGND.REPIGRKGRPA..--RP..AKEKI.S.RRRLR....EEEYDD...........--..--EYD...DY-....DD...E....D....EEPM......PRK.........GR...GrG.RKP..RGK.RG.....W.FWL.LVKICIVLAVL......
A0A1C3Z9J0_9ENTR/1-78                .........MAGND.REPIGRKGKPV..--RP..AKEKI.S.RRRLR....EEEYDD...........--..---YD...D-D....DD...E....D....EEPM......PKK.........GK...G.KgGKP..RGK.RG.....W.FWL.LLKIFIILAVL......
A0A0J8YWE8_9GAMM/1-78                .........MSGND.REPIGRKGKST..PKGK..SPPAS.P.RNKKY....QDDPDS...........--..---YD...DE-....-E...N....T....SLPA......TKK........rGK...T.P.R-K..SHK.RS.....W.LGL.LLKIILVIAVI......
A0A0J8VNI1_9ENTR/1-81                .........MAGND.REPIGRKGRPA..--RP..VKEKV.S.RRRLR....EEEYDD...........EY..EDEEP...APR....--...-....-....----......TAKgrg...nggGG...K.G.RKP..AKK.RR.....W.LWF.LLKLFLILVVV......
A9MPL2_SALAR/1-74                    .........MAGND.REPIGRKGKPS..--RP..VKQKV.S.RRRQH....DDDYDD...........--..-----...---....DY...E....D....EEPM......PRK.........GK...GkG.RKP..RGK.RG.....W.LWL.LLKLFIVFVVL......
A0A370QPV3_9ENTR/2-53                .........MSGDD.REPIGRKGNKR..RSAP..PRRQApE.RRRPR....YDDDDD...........DY..RDDFR...DDD....DD...D....-....----......---.........--...-.-.---..---.--.....-.---.-----------r.....
W0HML6_9GAMM/1-74                    .........MSGDD.REPIGRHGRPS..GRKA..PRKAA.P.R-RRR....DDDYDD...........--..-----...---....DD...E....E....EYVM.....pPRK.........ER...G.G.A-P..RKK.RR.....L.LGW.FIRLVLLFVVV......
Q8X903_ECO57/1-79                    .........MAGND.REPIGRKGKPT..--RP..VKQKV.S.R-RRY....EDD---...........--..-DDYD...DYD....DY...E....D....EEPM......PRK.........GKgkgK.G.RKP..RGK.RG.....W.LWL.LLKLAIVFAVL......
A0A068QZ33_9GAMM/1-84                .........MSDDD.RQPIGRKGKKS..GLR-..-RGWA.S.KKRDR....RDHYDD...........EN..DDFDD...DED...eVM...T....D....KRKN......THK.........SE...A.R.QSK..KGR.RR.....F.LWL.LLKIVIVLAVL......
U2LMK6_SERFO/1-85                    .........MAGDD.REPIGRKGKQP..KRNQ..PRKAA.-.R-RHR....DDDYEE..........dEY..QDEYD...DDEy..dDD...E....E....EQRM......PPK.........VK...A.K.S-P..RKK.RR.....W.LGL.LIKLFLVIAVL......
E3G929_ENTLS/1-78                    .........MAGND.REPIGRKGKPA..--RP..AKQKI.S.RRQLR....EEEYDD...........EY..D----...--E....DD...E....E....DDSM......PRK.........GK...GkG.RKP..RGK.RG.....W.FWL.LVKLGIVFAVI......
A0A0L0AFX2_9ENTR/1-77                .........MAGND.REPIGRKGKPA..--RP..AKQKV.T.RRQQY....DDDYDD...........--..--EED...DV-....-P...P....P....RKTR......SKG.........NG...G.G.RKR..RGK.RG.....W.LWL.LLKIFIVFVVL......
D4E1W8_SEROD/1-86                    .........MAGDD.REPIGRKGKQP..KRS-..ASRKP.L.R-RRR....DDDYDDfe.......adDY..QDEYE...DED....YD...D....Q....EQRM......PRK.........VK...A.-.APP..RKK.RR.....W.LGL.IVKIILVIAVL......
A0A084A612_9GAMM/1-50                .........MAGDD.RKPIGRQGRQA..KRQ-..APRRP.M.R-RRR....DDDYDD...........--..YDDYD...DYD....EY...E....E....NE--......---.........--...-.-.---..---.--.....-.---.-----------y.....
A0A2D0KKD1_9GAMM/1-85                .........MSDDD.RQPIGRKDKKS..KHR-..-RGRQ.A.NKRHR....RDDYDD..........yEY..NDVED...END....TN...D....E....GELM......TKK.........GK...K.S.PQV..KKG.RK.....WiWLL.LLKILIVLAVL......
E0SBK6_DICD3/1-81                    .........MSRDD.REPIGRKRSAS..RHTP..PRKQA.T.R-RRR....DDDYDD...........DY..EEEYEedyDDD....ED...D....E....EEVM......SKR.........--...-.-.--P..RKK.RR.....W.LGL.LIRLFLIFVVV......
L0MAA6_ENTBF/1-79                    .........MAGND.REPIGRKGKPA..--RP..AKQKV.S.RRRLR....DEEYDD...........DY..DD---...---....DY...E....D....DEPM.....pPRKg.......kGK...G.G.K-P..RRK.HG.....W.FWL.LVKLAIVFAVL......
Q6D1Y4_PECAS/1-81                    .........MSQDD.REPIGRKGKAP..KRKP..ERKQA.I.R-RRR....DDDYDDd........ydDY..QDDYD...DDD....DY...D....G....DDTM......TRK.........--...-.-.--S..QRR.RR.....W.LGL.AIKLFLIFAV-a.....
A0A318WGR8_9ENTR/1-77                .........MAGND.REPIGRKGKPA..--RP..AKQKV.S.RRRLR....DEEYDD...........--..----D...D-Y....DD...E....D....EEPM......PRN.........GK...GkG.KKP..RRK.YG.....W.FWL.LVKLGIVFAVL......
A0A2G0Q475_9GAMM/1-78                .........MSDDD.RQPIGRKGKKS..GLR-..-RGRT.S.KKRNR....RDNYDD...........--..---YE...DN-....DF...D....E....DEVM......TKK.........GK...K.P.RRS..KQK.GN.....WaLWL.LLKIFIVLVLL......
A0A370QPV3_9ENTR/50-100              ........d-----.-----------..----..-----.-.-----....DDRYDD...........--..DDRYD...DDD....DY...D....D....EEDV......ARK.........--...K.P.K-K..SRK.RR.....L.LCL.LAKLALIVIA-vl....
W1GM52_KLEPN/1-79                    .........MAGDD.REPIGRKGRPS..--RP..TKQKV.T.RRRVR....EEDYDD...........--..--EYD...D-D....DY...E....D....EKPV......PRKa.......kGK...G.G.K-P..RRK.RS.....W.LWL.LVKLGIVFAVL......
T0QJE5_PHOTE/1-83                    .........MSGED.RRPIGRKGKKP..VSR-..-REPL.S.KRRHL....LDDNDN...........-Y..DDGYE...DDD...yDD...E....E....DQPM......TKR.........GK...N.S.RPP..KKK.WC.....W.FWL.LFKIFIVFAVL......
A0A495AIM7_9ENTR/1-80                .........MAGND.REPIGRKGKPA..--RP..VKEKV.S.RRRLR....EEEYDD...........--..---YD...D--....DY...D....D....EEPM.....pPRKg......kgGG...N.G.RPP..RKK.RR.....W.LWF.LLKLFVVFVVL......
A0A2N5EKD4_9GAMM/1-88                .........MSGDD.REPIGRKGKTPppVRKP..LRQRP.R.N--RR....DEDVEEi........edDV..EAGMA...EQD...nVN...K....G....KQRM......PRK.........VK...A.G.K-P..RKK.RG.....W.LGL.LVKIGIVLAV-g.....
A0A417PSE7_9CLOT/284-368             deqartvvm-----.-----NKGTSS..KIRN..SRKVE.V.PASRDe..dEDEEDD...........EY..EDDED...DED....ED...D....D....EELS......PAV.........EK...A.M.TVA..GVV.LA.....V.IIV.LIVL-------llvska
A0A085GNS5_9GAMM/1-102               .........MSGDD.REPIGRKGKPA..GRKP..SRSRP.V.R-RRR....DDDYEEf........ddDY..EEDRE...TDD....DY...D....D....EEDTrresrmSRKaaprkaaksGK...G.G.K-P..RSR.KR.....WwFWL.LFKLFIIFAIL......
A0A0T9LNE3_9GAMM/1-85                .........MS-DD.REPTGRKGKKP..AAKS..ASKRP.L.RRRRD....EDDYEE...........DYldDDDRD...DDD....YD...D....E....DKPV......PRK.........-V...K.S.RPA..RKK.RR.....W.LGL.LIKLFIVAVVL......
A0A2V1HAJ6_9GAMM/1-93                .........MAGDD.RKPIGRQGRQA..KRH-..APRRP.M.R-RRR....DDDYDEydeyeedeyqdEY..DDDED...DYD....EE...Y....E....EKRM......PRK.........VK...A.H.S-S..RKK.RR.....W.LWL.LFKLFLVVAA-l.....
A0A443I8W1_9GAMM/1-83                .........MSGND.REPIGRKGKQS..--SP..PRKPA.G.RGRRR....EDDYDE...........KF..EDYQD...DPD...nDN...E....E....IEPV......PRK.........GK...G.R.S-P..RKK.RG.....W.LGL.IIKLLLIFIV-a.....
A0A0G4JX91_9GAMM/1-82                .........MSRDD.REPIGRKGKTS..RRKP..ARRQE.V.R-RRR....DDDYDD...........DY..EDYQD...DFD....DD...D....DgyddEDAM......TNK.........--...-.-.--P..RKK.RR.....W.LGL.FIKLALIFAVL......
A0A1U6ID04_9ENTR/1-78                .........MAGND.REPIGRKSRPS..--RP..AKEKV.S.RRRVR....EEEYDD...........--..---YE...DD-....DG...D....E....QDSA......PRKg.......kGK...G.G.K-P..RGK.RR.....W.FWL.LLKICIVGAVL......
A0A2X2E2Y6_RAOPL/1-79                .........MAGDD.REPIGRKGKPS..--RP..AKQKV.T.RRRVR....DEDYDD...........--..--DYD...D-D....DY...E....D....EEPM......PKKa.......kGK...G.N.K-P..RRK.RT.....W.LWL.LFKLGIVVAVL......
A0A3N1ISS2_9ENTR/1-78                .........MAGND.REPIGRKGRTT..--RP..AKEKV.S.RRQLR....DEEYDD...........--..--DYE...D--....DD...E....D....EEPM......PRK.........GK...GkG.RGP..RGK.RG.....W.FWL.LLKIGIVFAVL......
D1P4I5_9GAMM/1-88                    .........MSGKD.LEPIGRRKKRS..AEK-..-NSSS.S.RRRRN....RDDYDD..........dLY..DDEDI...DDEy.ldDE...D....E....EEQM......TTK........sSK...K.N.KKR..KSK.WR.....W.FWL.LIKLMLVLAVI......
A0A2P5IVI4_9GAMM/1-79                .........MSGND.REPIGRKGKQP..--RP..PRNAT.R.RGRRR...dEEDFDN...........--..----D...DFA...dEV...E....E....KTPV......PRK.........SK...G.K.RPP..RGK.RR.....W.LGW.LIKLFLVFVVI......
A0A1H4EB36_9GAMM/1-76                .........MARDD.REPIGRKGKAP..-RKP..TRKQV.V.RRRRD....DDDYDD...........DY..E-EYD...DY-....DD...E....D....DEEM......SRK.........--...-.-.--P..GKK.RR.....W.LGL.ALKLLLVFVVV......
A0A378EB75_KLEPR/1-76                .........MAGDD.REPIGRKGRPS..--RP..TKQKV.T.RRRVR....EEDYDD...........--..--EYD...D-D....DY...E....D....EKPV......PRKa.......kGK...G.G.K-P..RRK.RS.....W.LWL.LVKLGL-----ss....
A0A0N0Z8D3_9GAMM/1-88                .........MSGKD.FEPIGKRKKTR..P--T..KKPAN.S.RRRQR....RDDYDEs........pfDD..EQFNE...HTE....YQ...Q....E....DELM......AKK.........SK...K.G.RPNkqKSK.WR.....W.FWL.LVKIALVITL-l.....
A0A240CCL5_SERFI/1-82                .........MAGDD.REPIGRKGKQP..KRTA..SRK-P.P.R-RRR....DDDYDD...........YE..EDEYD...DDE....YQ...E....E....EERM......PRK.........VK...A.-.TPP..RKK.RR.....W.LGL.MIKLILVIAVL......
J7SKR5_MORMO/1-94                    .........MSDFD.REPTGRRGSKA..SAGK..KRGRS.D.RRRRR....DEDYDDdie.....yddEF..GDDEP...DDD....DY...D....D....EEDSp...rmSKK.........GR...K.N.KPP..KRR.WR.....W.FWF.LVKLGIVMAIL......
K8W302_9GAMM/1-95                    .........MSGKD.LEPIGRRKKPV..KQK-..-KKPN.S.RRRRE....RDDYEEydd.....elfD-..---ND...DIDeqnlDD...E....E....NELM......AKKrqs...nkkSN...K.N.RSP..KSK.WR.....W.FWL.LVKIFIVFAVL......
U3TMS9_9ENTR/1-80                    .........MSGND.REPIGRKGKAP..--KP..PRNVT.R.RGRRRe..pEDDIDQ...........--..----D...DFD...eDD...E....E....SAPV......PPK.........GK...G.K.RPA..RGK.RR.....W.LGW.LIKLFLVFVVV......
A4W6P6_ENT38/1-78                    .........MAGND.REPIGRKGKPA..--RP..AKEKV.S.RRRLR....DEDYDD...........--..--DYE...D--....DD...E....D....QEPM......PRN.........GK...GkG.RKP..RGR.RG.....W.FWL.LLKLFIVFVA-l.....
W1FUK4_ECOLX/1-78                    .........MAGND.REPIGRKGKPS..--RP..VKQKV.S.RRQLR....DEEYDD...........--..--DYD...D-D....DY...E....D....EEPM......PRK.........GK...GkG.RKP..RGK.RG.....W.FWL.LVKLSIVF---wc....
W1DUE4_KLEPN/1-79                    .........MAGDD.REPIGRKGRPS..--RP..TKQKV.T.RRRVR....EEDYDD...........--..--EYD...D-D....DY...E....D....EKPV......PRKa.......kGK...G.G.K-P..RRK.RS.....W.LWL.LVKLGIVFAVL......
A0A1T4NMR7_ENTAG/1-78                .........MSGND.REPIGRKGKPL..---P..PRSSA.G.RGRRR....DIEQDI...........--..--DQD...DFN....DD...E....E....EAPV......PRK.........GK...G.G.KPP..RGK.RR.....W.LGW.LIKLFLVFVVV......
E9CN74_9GAMM/1-75                    .........MAGDN.REPIGRKEKQP..K---..--RTA.S.R--RR....RDDYDN...........--..QDLYD...DDV....GK...Q....E....EEPM......PRK.........VK...A.-.TPP..HKK.RR.....W.LGL.MIKLLLVIA--al....
A0A0U5KZP4_9GAMM/1-79                .........MSGDD.REPIGRKGKSS..--TP..PRKPA.V.KGRRR....EREEEN...........--..--VQD...DFD...nDE...E....E....VAPM......PRK.........GK...G.R.P-P..VKK.RR.....W.LGL.LIKLFLVFVV-a.....
A0A071LWQ4_9ENTR/1-84                .........MAGND.REPIGRKPKSG..--RP..SKPKA.S.RRGHR....DDDYDD...........DY..DD-YD...DEY....ED...E....D....EEPMp....sKRK.........GK...K.K.SPP..GKK.RW.....L.LWL.LVKLFIIFAVI......
A0A095V6S1_9GAMM/1-77                .........MSGND.REPIGRKGKTP..RQTE..KARKP.A.-KRNK....NSHYDD...........--..----Q...DIN....EY...A....E....EQSL......PRK.........GK...K.K.P-P..VKK.RR.....W.LGL.FIKLFLVAAVV......
A0A014N8J2_9GAMM/1-76                .........MS-DD.REPIGRKGKQP..--NP..PRKVA.G.RRERR....DDD-DD...........--..--FQD...DGY....DH...E....E....KKPV......PRK.........GK...G.R.S-P..RRK.RG.....W.LGL.FIKLLLIFIVV......
A0A2G8E8T3_9GAMM/1-76                .........MSGND.RQPIGRKGKQP..--RP..PRKRA.Q.HGRQT....EDEYDD...........--..----I...DDE....QE...E....E....VTSV......PRK.........GR...G.G.P-P..GRK.RR.....W.LGL.FIKLFLIFIVV......
I2BCM2_SHIBC/1-89                    .........MAGND.REPIGRKGKPT..--RP..GKEKV.S.RRRLR....EEDYDD...........DY..QDDED...DYD....DD...Y....D....EQPV......SRKkmt...gkrGK...N.G.RPP..RRK.RR.....L.LWF.LVKLFIIGVVL......
W1I1F0_KLEPN/1-79                    .........MAGDD.REPIGRKGRPS..--RP..TKQKV.T.RRRVR....EEDYDD...........--..--EYD...D-D....DY...E....D....EKPV......PRKa.......kGK...G.G.K-P..RRK.RS.....W.LWL.LVKLGIVFAVL......
W1J9U1_9GAMM/1-82                    .........MSDDD.RQPIGRKGKKS..GHRR..GRQAN.K.RHRRD....DYDYDD...........--..--FED...ESN....ND...D....E....NEVM......TKK.........GN...K.S.PQV..KRR.GK.....WvWLL.LLKIFIVLTVL......
#=GC SS_cons                         .........XXXXX.XXXXXXXXXXX..--XX..XXXXX.X.X-XXX....XXX---...........--..-XXXX...XXX....XX...X....X....XXXX......XXX.........XXXXXX.X.XXX..XXX.XX.....X.XXX.THHHHHHHHHH......
#=GC seq_cons                        .........MuGsD.REPIGRKGK.s....+P..s+p+s.s.RtRpR....-DDYDD.................p.D...D.c....Dt...-....-....-csh......PRK.........GK...s.s.+.P..R+K.Rp.....W.LhL.LlKLhlVhsVl......
//
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