GenomeNet

Database: Pfam
Entry: PF00096
LinkDB: PF00096
Original site: PF00096 
#=GF ID   zf-C2H2
#=GF AC   PF00096.27
#=GF DE   Zinc finger, C2H2 type
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Boehm S;0000-0002-9538-9279
#=GF AU   Sonnhammer ELL;0000-0002-9015-5588
#=GF AU   Gago F;0000-0002-3071-4878
#=GF SE   Boehm S
#=GF GA   25.20 15.80;
#=GF TC   25.20 15.80;
#=GF NC   25.10 15.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   Zinc_finger
#=GF RN   [1]
#=GF RM   9171100
#=GF RT   Variations of the C2H2 zinc finger motif in the yeast genome and
#=GF RT   classification of yeast zinc finger proteins. 
#=GF RA   Boehm S, Frishman D, Mewes HW; 
#=GF RL   Nucleic Acids Res 1997;25:2464-2469.
#=GF RN   [2]
#=GF RM   12683994
#=GF RT   Assessment by molecular dynamics simulations of the structural
#=GF RT   determinants of DNA-binding specificity for transcription factor
#=GF RT   Sp1. 
#=GF RA   Marco E, Garcia-Nieto R, Gago F; 
#=GF RL   J Mol Biol 2003;328:9-32.
#=GF DR   INTERPRO; IPR013087;
#=GF DR   PROSITE; PDOC00028;
#=GF DR   PRINTS; PR00048;
#=GF DR   SCOP; 1zaa; fa;
#=GF DR   HOMSTRAD; zf-CCHH;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The C2H2 zinc finger is the classical zinc finger domain. The
#=GF CC   two conserved cysteines and histidines co-ordinate a zinc ion.
#=GF CC   The following pattern describes the zinc finger.
#=GF CC   #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any
#=GF CC   amino acid, and numbers in brackets indicate the number of
#=GF CC   residues. The positions marked # are those that are important
#=GF CC   for the stable fold of the zinc finger. The final position can
#=GF CC   be either his or cys. The C2H2 zinc finger is composed of two
#=GF CC   short beta strands followed by an alpha helix. The amino
#=GF CC   terminal part of the helix binds the major groove in DNA binding
#=GF CC   zinc fingers. The accepted consensus binding sequence for Sp1 is
#=GF CC   usually defined by the asymmetric hexanucleotide core GGGCGG but
#=GF CC   this sequence does not include, among others, the GAG (=CTC)
#=GF CC   repeat that constitutes a high-affinity  site for Sp1 binding to
#=GF CC   the wt1 promoter [2].
#=GF SQ   734380
#=GS F7EWL9_MONDO/496-518        AC F7EWL9.2
#=GS A0A2J7Q2M3_9NEOP/99-121     AC A0A2J7Q2M3.1
#=GS A0A2Y9R9J0_TRIMA/520-542    AC A0A2Y9R9J0.1
#=GS A0A091CPK1_FUKDA/475-497    AC A0A091CPK1.1
#=GS A0A0L7R670_9HYME/476-499    AC A0A0L7R670.1
#=GS A0A455AT52_PHYMC/258-280    AC A0A455AT52.1
#=GS A0A2K5SI22_CEBCA/447-469    AC A0A2K5SI22.1
#=GS A0A484BFN4_DRONA/424-446    AC A0A484BFN4.1
#=GS K7JH19_NASVI/444-466        AC K7JH19.1
#=GS A0A2R9A6K6_PANPA/323-345    AC A0A2R9A6K6.1
#=GS A0A3B5K8G8_TAKRU/180-202    AC A0A3B5K8G8.1
#=GS A0A087TYA2_9ARAC/370-392    AC A0A087TYA2.1
#=GS A0A3Q2DZ36_CYPVA/375-397    AC A0A3Q2DZ36.1
#=GS F6Z2N9_MONDO/471-493        AC F6Z2N9.1
#=GS ZNF22_MOUSE/139-161         AC Q9ERU3.2
#=GS A0A3Q0DW92_TARSY/525-547    AC A0A3Q0DW92.1
#=GS A0A2D0S935_ICTPU/384-406    AC A0A2D0S935.1
#=GS A0A3B4D5H6_PYGNA/297-321    AC A0A3B4D5H6.1
#=GS F1SN91_PIG/392-414          AC F1SN91.3
#=GS A0A2Y9S107_TRIMA/333-355    AC A0A2Y9S107.1
#=GS A0A2G5B1Q5_COERN/22-46      AC A0A2G5B1Q5.1
#=GS A0A1S3JPN1_LINUN/535-560    AC A0A1S3JPN1.1
#=GS A0A3P8NDW1_ASTCA/1697-1721  AC A0A3P8NDW1.1
#=GS A0A3P8ZB61_ESOLU/221-243    AC A0A3P8ZB61.1
#=GS K7ETV8_PONAB/308-330        AC K7ETV8.1
#=GS A0A2D0QN84_ICTPU/451-473    AC A0A2D0QN84.1
#=GS A0A2I3G259_NOMLE/917-940    AC A0A2I3G259.1
#=GS G3I726_CRIGR/500-522        AC G3I726.1
#=GS A0A3P9A8J4_ESOLU/467-490    AC A0A3P9A8J4.1
#=GS B3MKK8_DROAN/981-1003       AC B3MKK8.2
#=GS E1BHF3_BOVIN/380-402        AC E1BHF3.3
#=GS C3XWU1_BRAFL/10-32          AC C3XWU1.1
#=GS A0A1A9WD68_9MUSC/365-387    AC A0A1A9WD68.1
#=GS A0A2K5RL34_CEBCA/603-625    AC A0A2K5RL34.1
#=GS A0A3Q3AJ21_KRYMA/372-394    AC A0A3Q3AJ21.1
#=GS A0A2Y9PTL2_DELLE/822-846    AC A0A2Y9PTL2.1
#=GS A0A087YBN1_POEFO/276-298    AC A0A087YBN1.2
#=GS A0A3Q7SIS9_VULVU/413-436    AC A0A3Q7SIS9.1
#=GS A0A182UW89_ANOME/323-345    AC A0A182UW89.1
#=GS A0A452SBN5_URSAM/329-351    AC A0A452SBN5.1
#=GS A0A0R3SLQ9_HYMDI/86-109     AC A0A0R3SLQ9.1
#=GS A0A452SEE8_URSAM/87-109     AC A0A452SEE8.1
#=GS A0A498M6J8_LABRO/622-644    AC A0A498M6J8.1
#=GS A0A182M0T1_9DIPT/64-87      AC A0A182M0T1.1
#=GS A0A1S3RXB5_SALSA/269-291    AC A0A1S3RXB5.1
#=GS F6U8G4_MACMU/988-1010       AC F6U8G4.2
#=GS A0A384BKE1_URSMA/466-488    AC A0A384BKE1.1
#=GS A0A2P8ZF57_BLAGE/135-157    AC A0A2P8ZF57.1
#=GS A2A799_MOUSE/285-307        AC A2A799.1
#=GS A0A218UUQ2_9PASE/206-229    AC A0A218UUQ2.1
#=GS A0A084WPS3_ANOSI/71-93      AC A0A084WPS3.1
#=GS H2UIU3_TAKRU/315-339        AC H2UIU3.2
#=GS A0A1A9XPM7_GLOFF/407-429    AC A0A1A9XPM7.1
#=GS A0A3B3ID19_ORYLA/112-134    AC A0A3B3ID19.1
#=GS A0A452GMG8_9SAUR/130-152    AC A0A452GMG8.1
#=GS A0A3B5R8N2_XIPMA/106-128    AC A0A3B5R8N2.1
#=GS A0A2K5EC50_AOTNA/449-470    AC A0A2K5EC50.1
#=GS A5DUH2_LODEL/139-162        AC A5DUH2.1
#=GS A0A2K6QC09_RHIRO/793-815    AC A0A2K6QC09.1
#=GS M3Y3Q5_MUSPF/503-525        AC M3Y3Q5.1
#=GS A0A199UJ12_ANACO/265-290    AC A0A199UJ12.1
#=GS A0A2I2UE88_FELCA/237-259    AC A0A2I2UE88.2
#=GS X1WDK1_DANRE/294-316        AC X1WDK1.1
#=GS A0A0L8G402_OCTBM/248-270    AC A0A0L8G402.1
#=GS J9LQQ8_ACYPI/31-53          AC J9LQQ8.2
#=GS A0A3Q2ZZZ1_KRYMA/235-257    AC A0A3Q2ZZZ1.1
#=GS A0A340Y7P2_LIPVE/604-626    AC A0A340Y7P2.1
#=GS A0A0L8FV23_OCTBM/59-81      AC A0A0L8FV23.1
#=GS A0A0L8HSF2_OCTBM/510-532    AC A0A0L8HSF2.1
#=GS A0A2G8LIM9_STIJA/66-88      AC A0A2G8LIM9.1
#=GS F7B6R4_MONDO/435-457        AC F7B6R4.2
#=GS A0A096NWH9_PAPAN/487-509    AC A0A096NWH9.2
#=GS A0A0G2KC95_DANRE/120-142    AC A0A0G2KC95.1
#=GS A0A369JNC6_HYPMA/463-485    AC A0A369JNC6.1
#=GS A0A1A9W375_9MUSC/165-187    AC A0A1A9W375.1
#=GS A0A3Q7TLK3_URSAR/289-311    AC A0A3Q7TLK3.1
#=GS U3KMA3_RABIT/409-431        AC U3KMA3.1
#=GS H2R1B3_PANTR/431-453        AC H2R1B3.1
#=GS A0A1D5RKS7_MACMU/520-542    AC A0A1D5RKS7.1
#=GS A0A2R2MMH6_LINUN/212-234    AC A0A2R2MMH6.1
#=GS V4BAL9_LOTGI/51-73          AC V4BAL9.1
#=GS A0A2K5LW78_CERAT/656-678    AC A0A2K5LW78.1
#=GS A0A3B3Z1R0_9TELE/494-516    AC A0A3B3Z1R0.1
#=GS A6QQT2_BOVIN/579-601        AC A6QQT2.1
#=GS H0WE53_DANRE/150-172        AC H0WE53.1
#=GS H0VB87_CAVPO/321-343        AC H0VB87.2
#=GS A0A2U4BU86_TURTR/404-426    AC A0A2U4BU86.1
#=GS A0A3Q1EMJ6_9TELE/245-267    AC A0A3Q1EMJ6.1
#=GS A0A1U7SVX9_ALLSI/240-262    AC A0A1U7SVX9.2
#=GS A0A3P9D408_9CICH/463-485    AC A0A3P9D408.1
#=GS H0YZ33_TAEGU/250-273        AC H0YZ33.1
#=GS K8F4A0_9CHLO/146-168        AC K8F4A0.1
#=GS B4GST2_DROPE/452-472        AC B4GST2.1
#=GS A0A0L8FSH2_OCTBM/198-220    AC A0A0L8FSH2.1
#=GS A0A2K5HUZ4_COLAP/308-330    AC A0A2K5HUZ4.1
#=GS E0VCZ9_PEDHC/725-747        AC E0VCZ9.1
#=GS A0A2K6LPH2_RHIBE/277-299    AC A0A2K6LPH2.1
#=GS ZNF43_HUMAN/734-756         AC P17038.4
#=GS A0A3Q7VC04_URSAR/425-447    AC A0A3Q7VC04.1
#=GS J9JWR5_ACYPI/521-543        AC J9JWR5.2
#=GS A0A1L1RMB1_CHICK/334-356    AC A0A1L1RMB1.2
#=GS A0A3B4TGL8_SERDU/542-567    AC A0A3B4TGL8.1
#=GS A0A3Q7XD35_URSAR/367-389    AC A0A3Q7XD35.1
#=GS I3N8Y0_ICTTR/499-521        AC I3N8Y0.2
#=GS A0A2I4BU78_9TELE/243-265    AC A0A2I4BU78.1
#=GS A0A3Q7TBD8_VULVU/207-229    AC A0A3Q7TBD8.1
#=GS A0A096NPT9_PAPAN/494-516    AC A0A096NPT9.2
#=GS A0A2U4AU31_TURTR/482-504    AC A0A2U4AU31.1
#=GS A0A2A2M0C6_9BILA/37-59      AC A0A2A2M0C6.1
#=GS A0A2I3LGC3_PAPAN/455-477    AC A0A2I3LGC3.1
#=GS F1SBH6_PIG/522-544          AC F1SBH6.3
#=GS A0A2K6Q4Y2_RHIRO/268-290    AC A0A2K6Q4Y2.1
#=GS A0A3B5KM93_TAKRU/616-638    AC A0A3B5KM93.1
#=GS A0A3M0JSA4_HIRRU/357-379    AC A0A3M0JSA4.1
#=GS A0A087XP33_POEFO/393-415    AC A0A087XP33.2
#=GS A0A074SAN8_9AGAM/235-259    AC A0A074SAN8.1
#=GS A0A452FUM3_CAPHI/514-536    AC A0A452FUM3.1
#=GS A0A0L8I5E4_OCTBM/240-262    AC A0A0L8I5E4.1
#=GS A0A340XCK9_LIPVE/633-655    AC A0A340XCK9.1
#=GS A0A096P473_PAPAN/495-517    AC A0A096P473.2
#=GS A0A0L8I5G5_OCTBM/263-285    AC A0A0L8I5G5.1
#=GS A0A2I0MG85_COLLI/128-150    AC A0A2I0MG85.1
#=GS A0A337SD31_FELCA/504-526    AC A0A337SD31.1
#=GS A0A2Y9J5V4_ENHLU/330-352    AC A0A2Y9J5V4.1
#=GS A0A3B4Z098_9TELE/553-577    AC A0A3B4Z098.1
#=GS A0A2U3ZCM5_ODORO/229-251    AC A0A2U3ZCM5.1
#=GS A0A067QUM5_ZOONE/554-576    AC A0A067QUM5.1
#=GS A0A0L0HEL5_SPIPD/35-58      AC A0A0L0HEL5.1
#=GS A0A2K5D386_AOTNA/265-287    AC A0A2K5D386.1
#=GS W4Y8Y7_STRPU/493-515        AC W4Y8Y7.1
#=GS A0A1U8CNE6_MESAU/510-532    AC A0A1U8CNE6.2
#=GS A0A1D1USA7_RAMVA/354-377    AC A0A1D1USA7.1
#=GS K7F348_PELSI/375-397        AC K7F348.1
#=GS G5B7L3_HETGA/51-73          AC G5B7L3.1
#=GS G3RDY2_GORGO/356-378        AC G3RDY2.2
#=GS L5KV85_PTEAL/168-190        AC L5KV85.1
#=GS Q6WGJ9_NEMVE/208-230        AC Q6WGJ9.1
#=GS A0A2I2YX66_GORGO/291-313    AC A0A2I2YX66.1
#=GS D2HRB7_AILME/393-415        AC D2HRB7.1
#=GS F6SQ90_HORSE/376-398        AC F6SQ90.2
#=GS A0A3Q0T3N5_AMPCI/213-235    AC A0A3Q0T3N5.1
#=GS A0A3B3RZ79_9TELE/421-443    AC A0A3B3RZ79.1
#=GS A0A2K5IHV4_COLAP/595-617    AC A0A2K5IHV4.1
#=GS A0A2K5MHN8_CERAT/307-329    AC A0A2K5MHN8.1
#=GS A0A0L8FFJ0_OCTBM/82-104     AC A0A0L8FFJ0.1
#=GS A0A2I3T9V9_PANTR/544-566    AC A0A2I3T9V9.1
#=GS A0A3Q3FLH9_9LABR/279-301    AC A0A3Q3FLH9.1
#=GS H2Y5B4_CIOSA/453-475        AC H2Y5B4.1
#=GS A0A087UQ94_9ARAC/11-32      AC A0A087UQ94.1
#=GS A0A0N4STU4_DANRE/80-102     AC A0A0N4STU4.2
#=GS A0A2I3LEQ1_PAPAN/273-295    AC A0A2I3LEQ1.1
#=GS A0A0L8FIX9_OCTBM/396-418    AC A0A0L8FIX9.1
#=GS L8Y7X3_TUPCH/325-347        AC L8Y7X3.1
#=GS A0A2R8Q568_DANRE/101-123    AC A0A2R8Q568.1
#=GS A0A3B5K8Q6_TAKRU/468-490    AC A0A3B5K8Q6.1
#=GS A0A3P8YSX5_ESOLU/183-205    AC A0A3P8YSX5.1
#=GS A0A3S2NL31_CHISP/290-312    AC A0A3S2NL31.1
#=GS A0A2K6UID7_SAIBB/265-287    AC A0A2K6UID7.1
#=GS T1GC17_MEGSC/351-373        AC T1GC17.1
#=GS A0A3B1JFW3_ASTMX/370-394    AC A0A3B1JFW3.1
#=GS A0A1B0AHY8_GLOPL/249-271    AC A0A1B0AHY8.1
#=GS A0A2J7R2P7_9NEOP/300-322    AC A0A2J7R2P7.1
#=GS A0A087TJ00_9ARAC/68-90      AC A0A087TJ00.1
#=GS H2PRD8_PONAB/235-257        AC H2PRD8.1
#=GS A0A3P9AFF6_ESOLU/74-94      AC A0A3P9AFF6.1
#=GS V2XBU2_MONRO/48-73          AC V2XBU2.1
#=GS A0A1D5Q1E1_MACMU/228-250    AC A0A1D5Q1E1.1
#=GS A0A3B3DX72_ORYME/169-191    AC A0A3B3DX72.1
#=GS A0A3Q3KF40_9TELE/356-378    AC A0A3Q3KF40.1
#=GS A0A2K6NB98_RHIRO/528-550    AC A0A2K6NB98.1
#=GS A0A482V7K5_9CUCU/443-466    AC A0A482V7K5.1
#=GS A0A2K6P273_RHIRO/351-373    AC A0A2K6P273.1
#=GS A0A177WKD4_BATDL/214-236    AC A0A177WKD4.1
#=GS A0A2K6MGT1_RHIBE/312-334    AC A0A2K6MGT1.1
#=GS A0A452QHN3_URSAM/460-482    AC A0A452QHN3.1
#=GS A0A1U8CY88_MESAU/427-449    AC A0A1U8CY88.1
#=GS OSR1_XENTR/196-218          AC Q66JF8.1
#=GS J9L823_ACYPI/482-504        AC J9L823.2
#=GS A0A0L8HVK7_OCTBM/119-141    AC A0A0L8HVK7.1
#=GS A0A340X0P3_LIPVE/400-422    AC A0A340X0P3.1
#=GS A0A3P8ZB47_ESOLU/508-530    AC A0A3P8ZB47.1
#=GS A0A2K5TV88_MACFA/228-250    AC A0A2K5TV88.1
#=GS F7F2F0_MACMU/593-615        AC F7F2F0.2
#=GS F1SH30_PIG/232-254          AC F1SH30.3
#=GS G1QLB7_NOMLE/132-154        AC G1QLB7.2
#=GS A0A3Q3MD40_9TELE/881-902    AC A0A3Q3MD40.1
#=GS A0A2U4BU19_TURTR/420-442    AC A0A2U4BU19.1
#=GS A0A3Q7SMC3_VULVU/939-961    AC A0A3Q7SMC3.1
#=GS A0A2I3TR30_PANTR/136-158    AC A0A2I3TR30.1
#=GS F0ZPG0_DICPU/119-141        AC F0ZPG0.1
#=GS A0A1L8FUS0_XENLA/530-552    AC A0A1L8FUS0.1
#=GS G1N4N1_MELGA/69-92          AC G1N4N1.1
#=GS A0A2K5WEW2_MACFA/722-744    AC A0A2K5WEW2.1
#=GS A0A455B3H5_PHYMC/328-352    AC A0A455B3H5.1
#=GS A0A2K6PRN1_RHIRO/249-271    AC A0A2K6PRN1.1
#=GS A0A3B5KRY5_TAKRU/193-213    AC A0A3B5KRY5.1
#=GS A0A2K6KY85_RHIBE/299-321    AC A0A2K6KY85.1
#=GS B0XB58_CULQU/346-367        AC B0XB58.1
#=GS A0A3M6TST6_9CNID/995-1017   AC A0A3M6TST6.1
#=GS A0A0L8GAT2_OCTBM/66-88      AC A0A0L8GAT2.1
#=GS A0A2K5M0A9_CERAT/968-990    AC A0A2K5M0A9.1
#=GS A0A2K5DD26_AOTNA/477-498    AC A0A2K5DD26.1
#=GS A0A3B3WKS9_9TELE/62-84      AC A0A3B3WKS9.1
#=GS A0A168NG55_MUCCL/11-34      AC A0A168NG55.1
#=GS A0A026VV19_OOCBI/493-515    AC A0A026VV19.1
#=GS A0A2K5M0J2_CERAT/307-329    AC A0A2K5M0J2.1
#=GS A0A3B5K8U0_TAKRU/155-177    AC A0A3B5K8U0.1
#=GS ZN574_PONAB/523-545         AC Q5R4P8.1
#=GS A0A3B5QB45_XIPMA/94-116     AC A0A3B5QB45.1
#=GS A0A2K6BPU8_MACNE/259-281    AC A0A2K6BPU8.1
#=GS A0A0J7KDR7_LASNI/186-209    AC A0A0J7KDR7.1
#=GS A0A0L8GY06_OCTBM/134-156    AC A0A0L8GY06.1
#=GS D4ASC4_ARTBC/26-48          AC D4ASC4.1
#=GS A0A3P8X9I0_ESOLU/419-441    AC A0A3P8X9I0.1
#=GS G1LE67_AILME/311-333        AC G1LE67.1
#=GS A0A3Q3A1T2_KRYMA/397-421    AC A0A3Q3A1T2.1
#=GS B4JFN4_DROGR/851-874        AC B4JFN4.1
#=GS A0A3M0JSF3_HIRRU/201-223    AC A0A3M0JSF3.1
#=GS G0PGT2_CAEBE/600-624        AC G0PGT2.1
#=GS L9KWM6_TUPCH/18-44          AC L9KWM6.1
#=GS A0A286XV44_CAVPO/211-233    AC A0A286XV44.1
#=GS A0A1D5RKG3_MACMU/320-342    AC A0A1D5RKG3.1
#=GS A0A3B4YG76_SERLL/327-349    AC A0A3B4YG76.1
#=GS A0A2K6NNY4_RHIRO/63-85      AC A0A2K6NNY4.1
#=GS G3IBE4_CRIGR/10-34          AC G3IBE4.1
#=GS A0A3Q0H317_ALLSI/170-192    AC A0A3Q0H317.1
#=GS F7AL50_XENTR/397-419        AC F7AL50.1
#=GS A0A2B4S532_STYPI/539-561    AC A0A2B4S532.1
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