GenomeNet

Database: Pfam
Entry: PF00559
LinkDB: PF00559
Original site: PF00559 
#=GF ID   Vif
#=GF AC   PF00559.19
#=GF DE   Retroviral Vif (Viral infectivity) protein
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Swiss-Prot
#=GF GA   25.00 25.00;
#=GF TC   25.10 77.80;
#=GF NC   24.90 19.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Viral_infectivity_factor
#=GF RN   [1]
#=GF RM   7769728
#=GF RT   Aberrant Gag protein composition of a human immunodeficiency
#=GF RT   virus type 1 vif mutant produced in primary lymphocytes. 
#=GF RA   Simm M, Shahabuddin M, Chao W, Allan JS, Volsky DJ; 
#=GF RL   J Virol 1995;69:4582-4586.
#=GF DR   INTERPRO; IPR000475;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Human immunodeficiency virus type 1 (HIV-1) Vif is required for 
#=GF CC   productive infection of T lymphocytes and macrophages. Virions 
#=GF CC   produced in the absence of Vif have abnormal core morphology and
#=GF CC    those produced in primary T cells carry immature core proteins 
#=GF CC   and low levels of mature capsid.
#=GF SQ   32
#=GS VIF_HV1A2/1-192       AC P03402.1
#=GS B3CKG9_SIV/1-183      AC B3CKG9.1
#=GS VIF_HV1EL/1-192       AC P04597.1
#=GS VIF_SIVCZ/1-193       AC P17284.1
#=GS VIF_SIVTN/1-198       AC Q8AII0.1
#=GS VIF_HV1B1/1-192       AC P69720.1
#=GS VIF_SIVEK/1-192       AC Q1A248.1
#=GS VIF_HV1AN/1-192       AC Q77374.1
#=GS Q89490_SIV/3-194      AC Q89490.1
#=GS Q89490_SIV/3-194      DR PDB; 3RWJ C; 1-8;
#=GS Q89490_SIV/3-194      DR PDB; 3RWI C; 1-10;
#=GS VIF_HV1H2/1-192       AC P69723.1
#=GS VIF_HV1YF/1-192       AC O91081.1
#=GS B7UES2_SIV/1-187      AC B7UES2.1
#=GS VIF_HV190/1-192       AC O70897.1
#=GS VIF_HV1MV/1-192       AC Q79667.1
#=GS VIF_HV1ET/1-192       AC Q75003.1
#=GS Q87109_SIVSA/1-194    AC Q87109.1
#=GS VIF_HV2BE/4-195       AC P18097.1
#=GS K4ISV4_9PLVG/1-193    AC K4ISV4.1
#=GS Q72499_9HIV1/1-192    AC Q72499.1
#=GS VIF_HV1VI/1-192       AC Q9QSR2.1
#=GS VIF_HV2ST/3-195       AC P20878.1
#=GS Q774X0_SIV/3-194      AC Q774X0.1
#=GS VIF_HV1B9/1-192       AC Q89428.1
#=GS Q9Q6W2_9HIV1/1-192    AC Q9Q6W2.1
#=GS VIF_HV1MA/1-192       AC P04599.1
#=GS C7TQ94_9HIV1/1-192    AC C7TQ94.1
#=GS C7TQ76_9HIV1/1-192    AC C7TQ76.1
#=GS VIF_HV192/1-192       AC O12159.1
#=GS VIF_HV1JR/1-192       AC P20877.1
#=GS A0A1B4WRJ9_SIV/3-198  AC A0A1B4WRJ9.1
#=GS VIF_SIVMB/1-192       AC Q1A266.1
#=GS VIF_HV2RO/3-195       AC P04595.1
VIF_HV1A2/1-192                  ....MENRWQVMIVWQVDRMRIRTWKSLVKHHMYISKKAKG.WFYRHHYESTHPRVS------SEVHIPL-GDAKLVITTYWGLHTGEREWH..LGQGVAIEW..RKKKYSTQVDPGLADQLIHLHYFDCFSESAIKNAILGYRVSP..RCEY-QAGHN...KVGSLQYLALAALI.....TPKKTKPPLPSVKKLTEDRWNKPQKTKGHRGSHTMNGH................................
B3CKG9_SIV/1-183                 ....MEKEWIAVPLIKISKGRFRRWSYWIAELI-QEKQAR-.----FLFGSWHVHAE--CFTRHIVRIPLQGHWEMQIRCYWNL-APEIGWIdtLGFNIRMVW..E-NKWETFITVKLADVLIHSQHFECWTQSAVKNTIRQGYLHPidSCKYH-QGHL...GVLTLQALCLQALQ.....HEQLRKRKAPNRR-------------------------tpgntrgssryarav.................
VIF_HV1EL/1-192                  ....MENRWQVMIVWQVDRMRIKTWKSLVKHHMYVSKKANR.WFYRHHYESPHPKIS------SEVHIPL-GEARLVIKTYWGLHTGEREWH..LGQGVSIEW..RKRRYSTQVDPGLADQLIHMYYFDCFSESAIRKAILGDIVSP..RCEY-QAGHN...KVGSLQYLALTALI.....APKQIKPPLPSVRKLTEDRWNKPQQTRGHRGSHTMNGH................................
VIF_SIVCZ/1-193                  ....MENRWQVMIVWQVDRMRIKTWNSLVKYHIYRSKKARG.WFYRHHYDHPNPKVA------SEIHIPFRDYSKLIVTTYWALSPGERAWH..LGHGVSIQW..RLGSYVTQVDPFTADRLIHSQYFDCFAETAIRRAILGQLVAP..RCEY-KEGHR...QVGSLQFLALKALI.....SERRHRPPLPSVAKLTEDRWNKHQRTKVHQENLTRNGH................................
VIF_SIVTN/1-198                  ....MENRWQVQVVWMIDRMRLRTWTSLVKHHIFTTKCCKD.WKYRHHYETDTPKRA------GEIHIPLTERSKLVVLHYWGLACGERPWH..LGHGIGLEW..RQGKYSTQIDPETADQLIHTRYFTCFAAGAVRQAILGERILT..FCHF-QSGHR...QVGTLQFLAFRKVVesqdkQPKGPRRPLPSVTKLTEDRWNKHRTTTGRRENHTLSG-c...............................
VIF_HV1B1/1-192                  ....MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARG.WFYRHHYESPHPRIS------SEVHIPL-GDARLVITTYWGLHTGERDWH..LGQGVSIEW..RKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSP..RCEY-QAGHN...KVGSLQYLALAALI.....TPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH................................
VIF_SIVEK/1-192                  ....MENRWQVMVVWQVDRMRVRTWNSLVKHHMYVSKKARG.WFYRHHYETDNPKIS------SEIHIPL-GEAKLVIVTYWGLMPGERPWH..LGHGVSIEW..RQGIYRTQIDPELADKLIHLYYFDCFTASAIRQAVLGRPVIP..KCEY-PAGHK...QVGSLQYLALIAWV.....GVQKRRPPLPSVTKLTEDRWNRHQKIKDHRGSHTTNG-l...............................
VIF_HV1AN/1-192                  ....MENRWQVLIVWQVDRQKVKAWNSLVKYHKYRSRKTEN.WWYRHHYESRNPRVS------SSVYIPV-GVAHVVVTTYWGLMPGERDEH..LGHGVSIEW..RYKKYKTQIDPETADRMIHLHYFTCFTASAVRKAILGQRVLT..KCEYP-TGHS...QVGTLQLLALRAVV.....KARSRKPPLPSVQKLTEDRWNKHLRIRDQLKSPSMNGH................................
Q89490_SIV/3-194                 ...e-EKRWIAVPTWRIPE-RLERWHSLIKYLKYKTKDLQK.VCY-----VPHFKVGWAWWTCSRVIFPLQEGSHLEVQGYWHL-TPEKGWL..STYAVRITW..YSKNFWTDVTPNYADILLHSTYFPCFTAGEVRRAIRGEQLLS..CCRFPRAHKY...QVPSLQYLALKVVS.....-DVRSQGENPTWKQWRRDNRRGLRMAKQNSRGDKQRG-g...............................
#=GR Q89490_SIV/3-194      SS    ...X-XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXX.XXX-----XXXXXXXXXXXXXXXXXXXXXX--S--S----XX-XXXXXXX..XXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXX...XXXXXXXXXXXXXX.....-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X...............................
VIF_HV1H2/1-192                  ....MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARG.WFYRHHYESPHPRIS------SEVHIPL-GDARLVITTYWGLHTGERDWH..LGQGVSIEW..RKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSP..RCEY-QAGHN...KVGSLQYLALAALI.....TPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH................................
VIF_HV1YF/1-192                  ....MENRWQVMVVWQVDRMKIRKWNSLVKHHMYVSKKAKG.WYYRHHYETHHPKIS------SEVHIPV-GQARLVTVTYWGLTTGEQSWH..LGHGVSIEW..RLRKYKTQVDPEMADKLIHLHYFDCFTASAIRQAVLGRPVLP..RCEY-PAGHK...QVGTLQYLALTAWV.....GAKKRKPPLPSVTKLTEDRWNEHQKMQGHRGNPIMNGH................................
B7UES2_SIV/1-187                 mewi------AVPMYRLNN-------GQVEHVKFMAKLAYKfWGY-HWIWQNCYKYPREWWTHGKIYIPVPG-GEIEITLYWHI-RHGKGLQ..NSGGVNFKY..IVGISWMYLTPEYVDFMVHLVYFACWTQSAIRKAILGMPDHR..YCQL-ETGHL...GVLSLQLLALRAVR.....NGRKSSRGSGAT--------------------------qgatgglgerhngrnycrgkkalsq.......
VIF_HV190/1-192                  ....MENRWQVMIVWQVDRMRINTWKSLVKYHMHISRKARG.WFYRHHFESTHPRIS------SEVHIPL-GEARLVITTYWGLNTGEREWH..LGQGVSIEW..RLKRYSTQVEPGLADQLIHMHYFDCFSESAIRKAILGRVVRP..RCNY-PAGHK...QVGTLQYLALTALV.....APKKIKPPLPSVRKLVEDRWNKPQKTRGHRGSHTMNGH................................
VIF_HV1MV/1-192                  ....MENRWQVLIVWQIDRQKVKAWNSLVKYHKYMSKKAAN.WRYRHHYESRNPKVS------SAVYIPV-AEADIVVTTYWGLMPGEREEH..LGHGVSIEW..QYKEYKTQIDPETADRMIHLHYFTCFTESAIRKAILGQRVLT..KCEY-LAGHS...QVGTLQFLALKAVV.....KVKRNKPPLPSVQRLTEDRWNKPWKIRDQLGSHSMNGH................................
VIF_HV1ET/1-192                  ....MENRWQVLIVWQVDRMKIRTWNSLVKHHMHISRRANG.WVYRHHYDSRHPKVS------SEVHIPL-GEARLIIKTYWGLQTGERDWH..LGHGVSIEW..RLRSYNTQVDPGLADHLIHMHYFDCFAESAIRKAILGYRVSP..RCDY-QAGHN...KVGSLQYLALTALI.....KPKKAKPPLPSVSKLVEDKWNKPQKTRGRRGNHTMNGH................................
Q87109_SIVSA/1-194               ....MEKHWIVRPLWKVTGGQQERWTSLVKYHMHVSKQCVH.WRY-----TPHTKIRWNWYSYQEWVIPLKDGALIKVTNYWHL-TPEKGWL..ETYATGIGY..SKGEWFTELDPWTADHIIHWSYFPCFTDRAVQQAIRGEKYLW..-CKH-QVGHQptgQVPSLQYLALRVYT.....NGLRR---------------------------------vaptsrrgssqgspqesqrrdtrmarnmgfaq
VIF_HV2BE/4-195                  ....DRN-WIVVPTWRVPG-RMEKWHALVKYLKYRTKDLEE.VRY-----VPHHKVGWAWWTCSRVIFPLQGKSHLEIQAYWNL-TPEKGWL..SSHAVRLTW..YTEKFWTDVTPDCADILIHSTYFSCFTAGEVRRAIRGEKLLS..CCNYPQAHKA...QVPSLQYLALVVVQ.....QNDRPQRKGTARKQWRRDHWRGLRVAREDHRSLKQGGS................................
K4ISV4_9PLVG/1-193               ....MENRWQVLIVWQVDRMKIRTWNSLVKHHMYISKRTKG.WFYRHHYESRHPKVS------SEVHIPL-GEARLVIKTYWGLQPGEREWH..LGHGVSIEW..RLRRYTTQIEPGLADQLIHLYYFDCFADSAIRKAILGHIVIP..RCDYQAGHNN...KVGSLQYLALTTLI.....KPKKIKPPLPSIKKLVEDRWNNPQKIRGRRGNHTMNGH................................
Q72499_9HIV1/1-192               ....MENRWQVMIVWQVDRMRINTWKRLVKHHMYISRKAKD.WFYRHHYESTNPKIS------SEVHIPL-GDAKLVITTYWGLHTGERDWH..LGQGVSIEW..RKKRYSTQVDPDLADQLIHLHYFDCFSESAIRNTILGRIVSP..RCEY-QAGHN...KVGSLQYLALAALI.....KPKQIKPPLPSVRKLTEDRWNKPQKTKGHRGSHTTNGH................................
VIF_HV1VI/1-192                  ....MENRWQLMIVWQVDRMRINTWKSLVKYHMYVSKKAKG.WSYRHHFQSRHPRVS------SEVHIPL-EEVKLVITTYWGLHPGEREWH..LGQGVSIEW..RQGKYRTQIDPGLADQLIHIYYFDCFSESAIRKAILGHRISP..RCNY-QAGHN...KVGSLQYLALTALI.....APEKTKPPLPSVQKLVEDRWNKPQETRGHRGSHTMNGH................................
VIF_HV2ST/3-195                  ..eg--KRWIAVPTWRVPG-RMERWHSLIKYLKYRTGDLEK.VCY-----VPHHKVGWAWWTCSRVIFPLKGESHLEIQAYWNL-TPEKGWL..SSYSVRLTW..YTEKFWTDVTPDCADSLIHSTYFSCFTAGEVRRAIRGEKLLS..CCNYPQAHKY...QVPSLQFLALVVVQ.....QNGRPQRDNTTRKQWRRNYRRGLRVARQDGRSHKQRGS................................
Q774X0_SIV/3-194                 ...e-EKRWIAVPTWRIPE-RLERWHSLIKYLKYKTKDLQK.VCY-----VPHFKVGWAWWTCSRVIFPLQEGSHLEVQGYWHL-TPEKGWL..STYAVRITW..YSKNFWTDVTPNYADILLHSTYFPCFTAGEVRRAIRGEQLLS..CCRFPRAHKY...QVPSLQYLALKVVS.....-DVRSQGENPTWKQWRRDNRRGLRMAKQNSRGDKQRG-g...............................
VIF_HV1B9/1-192                  ....MENRWQVMIVWQVDRMRIRTWKSLVKHHMYISGKAKG.WSYRHHYESTNPRIS------SEVHIPL-GDAKLVVTTYWGLHTGERDWH..LGQGVSIEW..RKKRYSTQVDPGLADRLIHLYYFDCFSDSAIRKSILGHIVSP..SCEY-QAGHN...KVGSLQYLALAALT.....TPRRIKPPFPSVTKLTEDRWNKPQKTKGHRGSHTMTGH................................
Q9Q6W2_9HIV1/1-192               ....MENRWQVMIVWQVDRMRIRTWNSLVKHHIYISKKARG.WVYKHHYESRNPRIS------SEVHIPL-GDAKLVIKTYWGLHTGERDWH..LGQGASIEW..RKERYSTQVDPNLADQLIHLYYFDCFSESAIRNAILGHRVSP..SCEY-RAGHN...KVGSLQYLALAALR.....TPKKIKPPLPSVTKLTEDRWNKPQRTKDHRGSHTMSGH................................
VIF_HV1MA/1-192                  ....MENRWQVMIVWQVDRMRIRTWHSLVKHHMYVSKKAKN.WFYRHHYESRHPKVS------SEVHIPL-GDARLVVRTYWGLQTGEKDWH..LGHGVSIEW..RQKRYSTQLDPDLADQLIHLYYFDCFSESAIRQAILGHIVSP..RCDY-QAGHN...KVGSLQYLALTALI.....APKKTRPPLPSVRKLTEDRWNKPQQTKGHRGSHTMNGH................................
C7TQ94_9HIV1/1-192               ....MENRWQVMIVWQVDRMRIRTWHSLVKYHMYRSKKAKG.WLYRHHYESRHPKVS------SEVHIPL-GDARLVIRTYWGLQTGEREWH..LGHGVSIEW..RLRRYSTQVDPGLADQLIHLQYFECFSDSAIRKAIVGQIIIH..KCEY-QAGHK...KVGSLQYLALKALV.....ATKRTKPPLPSVKKLTEDRWNKPQKTKGHRESHTMNGH................................
C7TQ76_9HIV1/1-192               ....MENRWQVMIVWQVDRMRIRTWHSIVKHHMYRSKKAKG.WFYRHHYESRHPKVC------SEVHIPI-EEARLVIRTYWGLQPGEKAWH..LGHGVSIEW..SQGKYSTQVDPDLADQLIHLQYFDCFSESTIRKAILGHRIIH..RCEY-QAGHS...KVGSLQYLALKTLV.....EPRGTKPPLPSVRKLTEDRWNEPQKTRGRRGNHSMNGH................................
VIF_HV192/1-192                  ....MENRWQVLIVWQVDRMKIRTWNSLVKHHMYVSRRASG.WYYRHHYESRHPKIS------SEVHIPL-GEARLVIITYWGLQTGERDWH..LGHGVSIEW..RLRRYSTRVDPGLADQLIHMHYFDCFADSAIRKAILGHRVSS..RCDY-QAGHN...KVGSLQYLALTALI.....KPKKIKPPLPSVKKLVEDRWNKPQKTRDRRGNHTMNGH................................
VIF_HV1JR/1-192                  ....MENRWQVMIVWQVDRMRIRTWNSLVKHHMYISGKAKG.WIYKHHYESTNPRVS------SEVQIPL-GDARLVITTYWGLHTGERDWH..LGQGVSMEW..RTRRYSTQVDPDLADQLIHLYYFDCFSESAIRNAILGHIVSP..RCEY-QAGHS...KVGSLQYLALTALI.....KPKKIKPPLPSVKKLTEDRWNKPQKTKGHRGSHTMNGH................................
A0A1B4WRJ9_SIV/3-198             ..re--KEWVMRITWRVDSEHISRWQGIVRYWMEK--RGIQ.WEY-----KMHYKIHWAWYTMCQYIIPL-ETGDIYVDMFWHL-TPQTGWL..STYAVGIQYlsYQGNYRTELDPGTADSMIHLHYFNCFTERAIQKAIRGERFV-..FCNYPEGHKQt.gQVQTLQFLALQAVQ.....DGFRRKRKQGKEARVARN--------------------lgfkqrtlgrvakryahrsqpr..........
VIF_SIVMB/1-192                  ....MENRWQVMIVWQVDRMRIKTWNSLVKHHMYVSRKARN.WFYRHHYESNNPKIS------SEVHIPL-GEAKLVITTYWGLTTGERAWH..LGHGVSIEW..RQRSYRTQIDPDLADQLIHLYYFDCFAESAIRKAILGQIVSP..RCEYP-TGHN...KVGSLQYLALSTLI.....KSKPRRPPLPSVRKLAEDRWNNSQKTRDHKGNHIMNGH................................
VIF_HV2RO/3-195                  ..ed--KRWIVVPTWRVPG-RMEKWHSLVKYLKYKTKDLEK.VCY-----VPHHKVGWAWWTCSRVIFPLKGNSHLEIQAYWNL-TPEKGWL..SSYSVRITW..YTEKFWTDVTPDCADVLIHSTYFPCFTAGEVRRAIRGEKLLS..CCNYPRAHRA...QVPSLQFLALVVVQ.....QNDRPQRDSTTRKQRRRDYRRGLRLAKQDSRSHKQR--ss..............................
#=GC SS_cons                     ...X-XXXXXXXXXXXXXX-XXXXXXXXXXXXXXXXXXXXX.XXX-----XXXXXXXXXXXXXXXXXXXXXX--S--S----XX-XXXXXXX..XXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXX...XXXXXXXXXXXXXX.....-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-X...............................
#=GC seq_cons                    ....MENRWQVhIVWQVDRMRI+TWpSLVKaHMYhSK+Acs.WhYRHHYESpHPKlS......SEVHIPL.G-A+LVIpTYWGLtTGERsWH..LGaGVSIEW..Rpc+YpTQVDPshADpLIHhaYF-CFo-SAIR+AILGchl.s..+C-Y.pAGHp...pVGSLQYLALpAll.....ps++hKPPLPSVpKLsEDRWNc.Qcs+s++tuHohNGH................................
//
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