GenomeNet

Database: Pfam
Entry: PF00948
LinkDB: PF00948
Original site: PF00948 
#=GF ID   Flavi_NS1
#=GF AC   PF00948.21
#=GF DE   Flavivirus non-structural Protein NS1 
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_157 (release 3.0)
#=GF GA   26.50 26.50;
#=GF TC   26.50 116.00;
#=GF NC   24.50 26.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9371625
#=GF RT   trans-Complementation of yellow fever virus NS1 reveals a role
#=GF RT   in early RNA replication. 
#=GF RA   Lindenbach BD, Rice CM; 
#=GF RL   J Virol 1997;71:9608-9617.
#=GF RN   [2]
#=GF RM   2174669
#=GF RT   Flavivirus genome organization, expression, and replication. 
#=GF RA   Chambers TJ, Hahn CS, Galler R, Rice CM; 
#=GF RL   Annu Rev Microbiol 1990;44:649-688.
#=GF DR   INTERPRO; IPR001157;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The NS1 protein is well conserved amongst the flaviviruses. It
#=GF CC   contains 12 cysteines, and undergoes glycosylation in a similar
#=GF CC   manner to other NS proteins.  Mutational analysis has strongly 
#=GF CC   implied a role for NS1 in the early stages of RNA replication.
#=GF SQ   5
#=GS POLG_YEFV1/780-1133       AC P03314.1
#=GS POLG_ZIKV/792-1145        AC Q32ZE1.1
#=GS POLG_ZIKV/792-1145        DR PDB; 5K6K A; 2-352;
#=GS POLG_ZIKV/792-1145        DR PDB; 5K6K B; 2-352;
#=GS POLG_DEN1W/777-1130       AC P17763.2
#=GS POLG_DEN1W/777-1130       DR PDB; 4OIG E; 178-352;
#=GS POLG_DEN1W/777-1130       DR PDB; 4OIG A; 178-352;
#=GS POLG_DEN1W/777-1130       DR PDB; 4OIG B; 178-352;
#=GS POLG_DEN1W/777-1130       DR PDB; 4OIG D; 178-352;
#=GS A0A1X3CWX3_9NEIS/1-130    AC A0A1X3CWX3.1
#=GS A0A182H7A6_AEDAL/170-376  AC A0A182H7A6.1
POLG_YEFV1/780-1133                  ..............QGCAINFGKRELKCGDGIFIFRDSDDWLNKYSYYPEDPVKLASIVKASFEEGKCGLNSVDSLEHEMWRSRADEINAIFEENEVDISVVVQDPKNVYQRGT-----HPFSRIRDGLQYGWKTWGKNLVFSPGRKNGSFIIDGKSRKECPFSNRVWNSFQIEEFGTGVFTTRVYMDAVFEYTIDCDGSILGAAVNGKKSAHGSPTFWMGSHEVNGTWMIHTLEALDYKECEWPLTHTI-GT.SVEESEMFMPRSIGGPVSSHNHIPGYKVQTNGPWMQVPLEVKREACPGTSVIIDGNCDGRGKSTRSTTDSGKVIPEWCCRSCTMPPVSFHGSDGCWYPMEIRPRKTHESHLVRSWVTAGEI...........
POLG_ZIKV/792-1145                   .............v-GCSVDFSKKETRCGTGVFIYNDVEAWRDRYKYHPDSPRRLAAAVKQAWEEGICGISSVSRMENIMWKSVEGELNAILEENGVQLTVVVGSVKNPMWRGP-QRLPVPVNE----LPHGWKAWGKSYFVRAAKTNNSFVVDGDTLKECPLEHRAWNSFLVEDHGFGVFHTSVWLKVREDYSLECDPAVIGTAVKGREAAHSDLGYWIES-EKNDTWRLKRAHLIEMKTCEWPKSHTLWTD.GVEESDLIIPKSLAGPLSHHNTREGYRTQVKGPWHSEELEIRFEECPGTKVYVEETCGTRGPSLRSTTASGRVIEEWCCRECTMPPLSFRAKDGCWYGMEIRPRKEPESNLVRSMVTAGS-t..........
#=GR POLG_ZIKV/792-1145        SS    .............E-EEEEETTTTEEEEEEEEEEE--SSSSS--EEEEES-HHHHHHHHHHHHHTT--EE--SSHHHHHHHHHHHHHHHHHHHHTT---EEEE----SSB---S-B-----SS------------SSGGCTS-----S-EEEESSS-TTTS-GGGEE-S-EEEEEEE--SSSEEEEEEE-SS---B--GGG-EEEEETTEEEEE-SSEEEEE-EESSSEEEEEEEES--B-SB--GGG-B--T.T--GGG-SS-GGGT---SGGG--TT----TTS-TTSSSEEEEES--TT-EEEE-TTS--S-S-BBSB-TT--B--EEEESS--SS-EEEEETTEEEE-TT-EESSS-GGGS-B-----XX-X..........
POLG_DEN1W/777-1130                  ..............SGCVINWKGRELKCGSGIFVTNEVHTWTEQYKFQADSPKRLSAAIGKAWEEGVCGIRSATRLENIMWKQISNELNHILLENDMKFTVVVGDVSGILAQGKKMIRPQPMEH-----KYSWKSWGKAKIIGADVQNTTFIIDGPNTPECPDNQRAWNIWEVEDYGFGIFTTNIWLKLRDSYTQVCDHRLMSAAIKDSKAVHADMGYWIES-EKNETWKLARASFIEVKTCIWPKSHTLWSN.GVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKTIHEWCCRSCTLPPLRFKGEDGCWYGMEIRPVKEKEENLVKSMVSAGSG...........
#=GR POLG_DEN1W/777-1130       SS    ..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---GGG-EEEEETTEEEEE-SSEEEEE-EESSSEEEEEEEESS-------GGG-BS-T.T--GGG-SS-GGGT--SSGGG--TT----TTS-GGGSSEEEEES--TT-EEEE-TTS--S-S-EESB-SS--B--EEEESS--SS-EEEE-SS-EEE-TTEEESS--SS---B--S--XXX...........
A0A1X3CWX3_9NEIS/1-130               .............q----------------------------------------------KAHKEGVCGLRSVSRLEHQMWEAVKDELNTLLKENGVDLSVVVEKQEGMYKSAP-----KRLTATTEKLEIGWKAWGKSILFAPELANNTSVVDGPETKECPTQNRAWNSLEVEDFGFGLTSTRMFLKVRESNT-----------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------...........
A0A182H7A6_AEDAL/170-376             sdirrmcgkaisfq------------------------------------------------------------------------------------------------------------------------------------------------------------FKFVGFRRGLYGSNVQVAVSKQVSHHCPTYLAGVAVKNDRTIITDGMFWMESEIVNGTQRIVVLEMLQSHRCLWPSTYTPDALpDPTDLNIFIPPVWGGPISKANHIPGYKMQTDFPWNNSDIILMQGPVPGTRVTVDPRCNGRMH---ARTVDPKSNETWCCQACDK-IIHFKVGDTYVYPMEIQ-------------------vgtmpaqeipr
#=GC SS_cons                         .............EXEEEEETTTTEEEEEEEEEEEXXSSSSSXXEEEEESXHHHHHHHHHHHHHTTXXEEXXSSHHHHHHHHHHHHHHHHHHHHTTXXXEEEEXXXXSSBXXXSXBXXXXXSSX-----XXXXXXSSGGCTSXXXXXSXEEEESSSXTTTSXGGGEEXSXEEEEEEEXXSSSEEEEEEEXSSXXXB--GGG-EEEEETTEEEEE-SSEEEEE-EESSSEEEEEEEESS-B-SB--GGG-BS-T.T--GGG-SS-GGGT--SSGGG--TT----TTS-CCCSSEEEEES--TT-EEEE-TTS--S-S-EESB-TT--B--EEEESS--SS-EEEEETTEEEE-TTEEESSS-CCGS-B--S--XXX...........
#=GC seq_cons                        ...............GCslsatt+Eh+CGsGlFlhp-scsWhppYpa.s-sPh+LuuhltpAaEEGlCGlpSVoRLEp.MW+ulpsELNsILcENsVcloVVVtcscshhtpGs.....pPhsc....LpaGWKuWGKuhlhusshpNsoFllDGsspKECPhppRAWNSFcVEDFGFGlFoTsVaLKVR-sYThcCDstlhGsAVKsc+usHuDhsaWhES.EhNsTW+ltphchl-hKpC.WPpoHTl.us.uVpES-hhIP+shGGPlSpHNahPGY+sQTsGPWppscLElch-.CPGTpVhVDtpCssRG.ShRoTTsoGKsIcEWCCRuCThPPlpF+upDGCWYsMEIRPhKp.EppLV+ShVoAGp............
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