GenomeNet

Database: Pfam
Entry: PF00949
LinkDB: PF00949
Original site: PF00949 
#=GF ID   Peptidase_S7
#=GF AC   PF00949.21
#=GF DE   Peptidase S7, Flavivirus NS3 serine protease 
#=GF PI   Flavi_helicase; 
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_199 (release 3.0)
#=GF GA   20.00 20.00;
#=GF TC   20.00 20.00;
#=GF NC   19.90 19.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7642575
#=GF RT   Association between NS3 and NS5 proteins of dengue virus type 2
#=GF RT   in the putative RNA replicase is linked to differential
#=GF RT   phosphorylation of NS5. 
#=GF RA   Kapoor M, Zhang L, Ramachandra M, Kusukawa J, Ebner KE,
#=GF RA   Padmanabhan R; 
#=GF RL   J Biol Chem 1995;270:19100-19106.
#=GF RN   [2]
#=GF RM   2174669
#=GF RT   Flavivirus genome organization, expression, and replication. 
#=GF RA   Chambers TJ, Hahn CS, Galler R, Rice CM; 
#=GF RL   Annu Rev Microbiol 1990;44:649-688.
#=GF RN   [3]
#=GF RM   8269709
#=GF RT   Evolution and taxonomy of positive-strand RNA viruses:
#=GF RT   implications of comparative analysis of amino acid sequences. 
#=GF RA   Koonin EV, Dolja VV; 
#=GF RL   Crit Rev Biochem Mol Biol 1993;28:375-430.
#=GF RN   [4]
#=GF RM   10026173
#=GF RT   Dengue virus NS3 serine protease. Crystal structure and insights
#=GF RT   into interaction of the active site with substrates by molecular
#=GF RT   modeling and structural analysis of mutational effects. 
#=GF RA   Murthy HM, Clum S, Padmanabhan R; 
#=GF RL   J Biol Chem 1999;274:5573-5580.
#=GF DR   INTERPRO; IPR001850;
#=GF DR   MEROPS; S7;
#=GF DR   MEROPS; S7;
#=GF DR   SCOP; 1bef; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The viral genome is a positive strand RNA that encodes a single 
#=GF CC   polyprotein precursor. Processing of the polyprotein precursor
#=GF CC   into mature proteins is carried out by the host signal peptidase
#=GF CC   and by NS3 serine  protease, which requires NS2B (Pfam:PF01002)
#=GF CC   as a cofactor [4]. 
#=GF SQ   28
#=GS C5J5N2_MYCCR/18-75        AC C5J5N2.1
#=GS A0A1B8AKE3_FUSPO/572-614  AC A0A1B8AKE3.1
#=GS A0A1Y2BIF4_9FUNG/83-126   AC A0A1Y2BIF4.1
#=GS Y591_MYCPN/171-291        AC Q50336.1
#=GS POLG_YEFV1/1502-1655      AC P03314.1
#=GS A0A0A8EBZ9_MYCFL/39-228   AC A0A0A8EBZ9.1
#=GS Y586_MYCPN/154-286        AC P75194.1
#=GS POLG_ZIKV/1515-1666       AC Q32ZE1.1
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GXJ A; 1018-1158;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GPI F; 19-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GJ4 F; 19-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GPI D; 18-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5T1V A; 82-222;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GXJ B; 1018-1158;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GJ4 H; 19-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5TFN B; 1017-1157;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GJ4 B; 19-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5T1V B; 82-223;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5TFN A; 1017-1160;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GJ4 D; 19-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GPI H; 17-168;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5TFO A; 1017-1158;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5TFO B; 1017-1157;
#=GS POLG_ZIKV/1515-1666       DR PDB; 5GPI B; 17-168;
#=GS Y580_MYCPN/2-70           AC P75200.1
#=GS C8W2Y8_DESAS/110-164      AC C8W2Y8.1
#=GS W4M1P4_9BACT/54-90        AC W4M1P4.1
#=GS A0A1Z5HQ28_9THEO/243-317  AC A0A1Z5HQ28.1
#=GS Q4AA40_MYCHJ/48-227       AC Q4AA40.1
#=GS A1TVN4_ACIAC/31-106       AC A1TVN4.1
#=GS Y589_MYCPN/14-134         AC Q50338.1
#=GS A0A1M4Z3P8_9FIRM/258-324  AC A0A1M4Z3P8.1
#=GS A0A0K9QPV2_SPIOL/111-151  AC A0A0K9QPV2.1
#=GS Y584_MYCPN/1-69           AC P75196.1
#=GS K8DZM9_9FIRM/257-324      AC K8DZM9.1
#=GS Y577_MYCPN/197-333        AC P75203.1
#=GS A0A1H7IQ85_9PROT/267-301  AC A0A1H7IQ85.1
#=GS POLG_DEN1W/1492-1643      AC P17763.2
#=GS POLG_DEN1W/1492-1643      DR PDB; 5WJL C; 1-10;
#=GS POLG_DEN1W/1492-1643      DR PDB; 5WKF C; 1-10;
#=GS POLG_DEN1W/1492-1643      DR PDB; 5WJL F; 1-10;
#=GS POLG_DEN1W/1492-1643      DR PDB; 3L6P A; 76-218;
#=GS POLG_DEN1W/1492-1643      DR PDB; 3LKW A; 76-218;
#=GS POLG_DEN1W/1492-1643      DR PDB; 5WKF H; 1-10;
#=GS POLG_DEN1W/1492-1643      DR PDB; 5WJL I; 1-10;
#=GS A0A0A2TJV7_9FIRM/47-90    AC A0A0A2TJV7.1
#=GS Y298_MYCGA/335-468        AC P33276.3
#=GS A0A0U5C451_9EURO/129-185  AC A0A0U5C451.1
#=GS A0A164NVM4_9CRUS/286-438  AC A0A164NVM4.1
#=GS R6X0L4_9BACT/402-439      AC R6X0L4.1
#=GS A0A182G8Y9_AEDAL/294-440  AC A0A182G8Y9.1
C5J5N2_MYCCR/18-75                   ....................................................................................................................................................................................lflytkd----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....KK.....INSI.................................................................N...DK.....L...Y.....V.EN..IDF..N..D..GSSGSPLFY-KNKIVG.V..Y.KGKEVVQ....-----------gkltsffn.........................
A0A1B8AKE3_FUSPO/572-614             ......................................................................................................................................................................................ltyca----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...-.....-.--..---..-..K..GDSGSIVFNKHGKVIG.L..Y.STGIKIRm..sLDNEEFGIV--t................................
A0A1Y2BIF4_9FUNG/83-126              .........................................................................................................................................................................................yy----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...-.....-.HN..VNT..N..N..GSSGSPLLNKNYKVLG.I..H.KAKEEYN....DNSFKQN----iai..............................
Y591_MYCPN/171-291                   ...........................................................................................................................................................................................WECKQGAERFSYGYFY..SNMA.......RLTKNLR.QG.------DPNAGSKTHI...EYSNELL.DKDS........M.DQGIVR.FS..TFL..G.A.NIN.YHD.....YD.....YRQQ.................................................................G...YG.....L...T.....L.TD..TNL..P..G..GSSGSLVFNQDKKISS.I..Y.SAATESD....----SVGYAQL.................................
POLG_YEFV1/1502-1655                 ..........................................................................................................................................................................................e-HLEDGIYGIFQSTFL..GASQ.......RGVGVAQ.GG.VFHTMWHVTRGAFLVR...NGKKLIP.SWAS........V.KEDLVA.YG..GSW..K.L.EGR.WDG....eEE.....VQLIaavpgknvvnv...........................................qtkpslfkvrnG...GE.....I...G.....A.VA..LDY..P..S..GTSGSPIVNRNGEVIG.L..Y.GNGILVG....DNSFVSAISQT.................................
#=GR POLG_YEFV1/1502-1655      AS    .........................................................................................................................................................................................................................................*....................................*.................................................................................................................................................*..........................................................................
A0A0A8EBZ9_MYCFL/39-228              ...................................................................................................................................................................iesnvfnfsvskgkqnlsrftatl----------------..----.......--LKKTK.EKlIFVTTHHSLNFVKLKI...NEQNFNI.HLEQ........F.SKINFE.IQ..IKS..K.F.KIE.YEN.....KE.....KDILlfslntskllpflttnfidfgvledftssknslfslgfvtllksnffpyasrllfytddkipeleE...DN.....V...L.....I.QN..IDY..S..Q..GSSGSPLFFRN-KLVG.L..Y.RGKK---....-----------ikskkl...........................
Y586_MYCPN/154-286                   ...........................................................................................................................................................................................YLLGYPFLRNKAASLF.lNQTEqrkehmdKTTQILH.EK.PFVVLTDPAKPTLIRN..kGANFTGN.TWTS........-.NYDLSK.KS..GLY..H.-.--K.FLG.....KK.....YQIY.................................................................G...KS.....I...V.....I.SD..LNL..S..S..GSSGSLLLNDRKQIVG.I..Y.FGVDGPK....---DELGFSQL.................................
POLG_ZIKV/1515-1666                  ...........................................................................................................................................................................................-ETTDGVYRVMTRRLL..GSTQ.......VGVGVMQ.EG.VFHTMWHVTKGAALRS...GEGRLDP.YWGD........V.KQDLVS.YC..GPW..K.L.DAA.WDG....lSE.....VQLLavppgerarni...........................................qtlpgifktkdG...-D.....I...G.....A.VA..LDY..P..A..GTSGSPILDKCGRVIG.L..Y.GNGVVIK....NGSYVSAITQ-g................................
#=GR POLG_ZIKV/1515-1666       SS    ...........................................................................................................................................................................................--S-SEEEEEEEEESS..SEEE.......EEEEEEE.TT.EEEEEHHHHTT--EEE...TTEEE-E.EEEE........T.TTTEEE.ES..SS-..-.-.---.B-S....SS-.....EEEEE--TTS--EEE...........................................EE--EEEEETTE...-E.....E...E.....E.E-..---..-..T..TGTTEEEE-TTS-EEE.E..T.TSEEEBT....TS-EEEE-B---................................
#=GR POLG_ZIKV/1515-1666       pAS   .........................................................................................................................................................................................................................................*....................................*.................................................................................................................................................*..........................................................................
Y580_MYCPN/2-70                      ........................................................................................................................................................................................taq----------------..----.......-------.--.----------------...-------.----........-.------.--..-YY..Q.L.DEK.FNQ.....QT.....YEQY.................................................................G...KG.....L...A.....L.ND..LYI..R..R..GASGSLVFNQDQQISG.I..F.FAVASHS....-----------dpkpgektlvql.....................
C8W2Y8_DESAS/110-164                 ........................................................................................................................................................................vgvtlqvqiseteigwfse----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....Q...V.....V.CD..MNS..Q..P..GDSGSLIVNNNKKAVG.L..L.FAG----....-----------sdkft............................
W4M1P4_9BACT/54-90                   ........................................................................................................................................................................................pfs----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...-.....-.--..---..S..G..GDSGSLIVNPARQAVG.L..L.FAGTDAG....-----------vtyanpi..........................
A0A1Z5HQ28_9THEO/243-317             ...............................................................................................................................................................vvrksgrttgvtegivkalhvnlkvnmg----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.--N.....DV.....YAMF.................................................................D...-D.....Q...V.....I.TS..MDS..A..G..GDSGSLVLDKNNQAVG.L..L.FAG----....-----------sdrftvf..........................
Q4AA40_MYCHJ/48-227                  ................................................eneknltrftatlvkktnnnltfvstfhslnsiknniqqqvfdiflqqfsvknletklkskirveyenkekdiivfsldikeplllrisdsidfqvledftntknslfslgfltilnedfkpktlktlfyvndkvveld----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................K...EN.....V...F.....V.QD..INY..R..Q..GSSGSPLFY-KNKIVG.L..Y.RGKK---....-----------lkngklt..........................
A1TVN4_ACIAC/31-106                  ................................................................................................................................................................pntavchsggtsgwrcgvqkstnsqqs----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....--IN.................................................................G...RT.....F...T.....L.SE..ANFcgA..P..GDSGGPVVNAENNALG.I..Y.TAALGKD....-----------ltgtcga..........................
Y589_MYCPN/14-134                    ...........................................................................................................................................................................................FEWTKTEQRFNHDDFY..GSMP.......TLTKNLR.QG.------QPVAGSKVHT...DYSNGFL.NEYS........L.NQGIVD.FG..TFK..S.A.ITD.YHG.....YE.....YKNH.................................................................G...YG.....L...A.....L.TD..TDL..L..G..GSSGSLVFNQDKKISS.I..Y.SAATESD....----SVGYAQL.................................
A0A1M4Z3P8_9FIRM/258-324             ................................................................................................................................................................trgvvtavgatmevklddessayfadq----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...V.....V.TD..MKS..Q..G..GDSGSLVLNEENKAVG.L..L.FAGS---....-----------dkvtvfnhi........................
A0A0K9QPV2_SPIOL/111-151             .......................................................................................................................................................................................iiqc----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...-.....-.NR..LNF..R..E..GCSGSPVFNTKGEIVG.M..L.-------....-----------icevnscdialh.....................
Y584_MYCPN/1-69                      ........................................................................................................................................................................................mny----------------..----.......-------.--.----------------...-------.----........-.-----D.LS..QKF..K.V.YLE.FSG.....KK.....YRIY.................................................................G...QS.....I...G.....I.SH..LDL..G..G..GSSGSLLLNDKKQIAG.I..Y.FGVDGAN....---NELGLAQL.................................
K8DZM9_9FIRM/257-324                 ................................................................................................................................................................itrgtvtavgatmevklddentayfad----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....Q...V.....V.TD..MKS..Q..G..GDSGSLVLNQENRAVG.L..L.FAGS---....-----------dkvtvcnhi........................
Y577_MYCPN/197-333                   ..........................................................................................................................................................................................v-ESNIAALNLNQTEVK.pTRPE.......-DVAQVT.FK.EPWSVDHHREIPTLTTnqlTTIKTKH.FSGS........K.LSWPFD.HT..KSF..K.I.KNK.WLG.....QN.....YQMY.................................................................G...HG.....L...G.....I.DQ..VNL..R..K..GTSSSLVINQKRQIVG.I..Y.FATVITNp.kkAVRNDVGLVQM.................................
A0A1H7IQ85_9PROT/267-301             ........................................................................................................................................................................................fgd----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...-.....-.--..---..-..N..GDSGSLIVNAAGEAVG.L..Y.FAGDPRD....-----------pyglan...........................
POLG_DEN1W/1492-1643                 ..........................................................................................................................................................................................v--LDDGIYRILQRGLL..GRSQ.......VGVGVFQ.EG.VFHTMWHVTRGAVLMY...QGKRLEP.SWAS........V.KKDLIS.YG..GGW..R.F.QGS.WNA....gEE.....VQVIavepgknpknv...........................................qtapgtfktpeG...-E.....V...G.....A.IA..LDF..K..P..GTSGSPIVNREGKIVG.L..Y.GNGVVTT....SGTYVSAIAQ-a................................
#=GR POLG_DEN1W/1492-1643      SS    ..........................................................................................................................................................................................X--XXXXXXXXEEEETT..CEEE.......EEEEEEE.TT.EEEEEHHHHTTXXEEE...TTEEEXE.EEEE........T.TTTEEE.ES..SSX..X.X.XXX.XXT....TXX.....EEEEEXXTTSXXEEE...........................................EEXXEEEEETTE...-E.....E...E.....E.EX..XXX..X..T..T-TTSEEE-TTSXEEE.E..C.EEEEEXT....TSXEEEEEEX-X................................
#=GR POLG_DEN1W/1492-1643      pAS   .........................................................................................................................................................................................................................................*....................................*.................................................................................................................................................*..........................................................................
A0A0A2TJV7_9FIRM/47-90               ........................................................................................................................................................................................ifi----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...-.....-.--..-QL..N..A..GNSGSPVINNQAQVVG.V..I.FGVTTFE....-----------negvsesrglai.....................
Y298_MYCGA/335-468                   ...........................................................................................................................................................................................WPTTPQYTKFSVPSLS..-RRQ.......IPITSDS.RG.SPGWTINALNPTELDG...QKIASST.SLSSt.....ggI.RAGIYN.AD..IAR..N.F.QLV.YRN.....VK.....YKQY.................................................................G...YG.....Y...I.....I.QN..SNL..S..A..GSSGSLALTSNNQALG.I..Y.FGTVSVD...aKKEATFGLVA-s................................
A0A0U5C451_9EURO/129-185             ....................................................................................................................................................................qtvyletwehtfthgrgsgkfvc----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...-.....-.--..---..R..P..GDSGSLVFNKDKKVVG.L..F.FGGSDTQ....----DVG----yfts.............................
A0A164NVM4_9CRUS/286-438             .........................................................................................................................................................................................kl---PDGVYAINAKGLL..GSRR.......VGASVVV.RG.VFHTCWRVTDSNPIVY...QERLLLP.HSTH........K.EQDIVT.YG..GPW..Q.-.-GV.VGE.....QD.....DLVTllalepndeivvnt.....................................adpgnieledvdgnV...KK.....C...R.....V.LW..ADH..P..P..GTSGSLILNPRGELVG.L..Y.GFG----....-----------fflstdrfgnyg.....................
R6X0L4_9BACT/402-439                 ........................................................................................................................................................................................avt----------------..----.......-------.--.----------------...-------.----........-.------.--..---..-.-.---.---.....--.....----.................................................................-...--.....-...-.....-.--..---..E..G..GSSGSPLFNQNKQIVG.T..L.SGGSSSC....-----------ekpngant.........................
A0A182G8Y9_AEDAL/294-440             ........................................................................................................................................................................................dlp----NGVYRIIVRSFM..ENRQ.......RGIGVAK.NG.VFHTLMHVTRGEPLNW...RGRLVSL.HSGS........A.LRDVVS.YG..GPW..Q.L.DSP.TVA.....DE.....VLLMackpdktvey............................................hkykpgvvkidD...ET.....V...M.....F.IS..VDF..G..K..GSSGSPFF-INGEVVG.F..Y.GYGF---....-----------yidgiyrsiva......................
#=GR A0A182G8Y9_AEDAL/294-440  pAS   .........................................................................................................................................................................................................................................*....................................*.................................................................................................................................................*..........................................................................
#=GC SS_cons                         ..........................................................................................................................................................................................X--SXSEEEEEEEEETT..CEEE.......EEEEEEE.TT.EEEEEHHHHTTXXEEE...TTEEEXE.EEEE........T.TTTEEE.ES..SSX..X.X.XXX.BXT....TSX.....EEEEEXXTTSXXEEE...........................................EEXXEEEEETTE...-E.....E...E.....E.EX..XXX..X..T..TGTTCEEE-TTSXEEE.E..C.CCEEEBT....TSXEEEEEEX-X................................
#=GC seq_cons                        .............................................................................................................................................................................................................................................................................................................................................................................................t.........h.....h.ps..hsh..p..s..GsSGS.llNpppclVG.l..Y.huu...p................................................
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