GenomeNet

Database: Pfam
Entry: PF01350
LinkDB: PF01350
Original site: PF01350 
#=GF ID   Flavi_NS4A
#=GF AC   PF01350.17
#=GF DE   Flavivirus non-structural protein NS4A
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_211 (release 3.0)
#=GF GA   20.60 20.60;
#=GF TC   21.40 21.30;
#=GF NC   20.50 20.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   2174669
#=GF RT   Flavivirus genome organization, expression, and replication. 
#=GF RA   Chambers TJ, Hahn CS, Galler R, Rice CM; 
#=GF RL   Annu Rev Microbiol 1990;44:649-688.
#=GF RN   [2]
#=GF RM   2541547
#=GF RT   Positive identification of NS4A, the last of the hypothetical
#=GF RT   nonstructural proteins of flaviviruses. 
#=GF RA   Speight G, Westaway EG; 
#=GF RL   Virology 1989;170:299-301.
#=GF DR   INTERPRO; IPR000404;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Flaviviruses encode a single polyprotein. This is cleaved into
#=GF CC   three structural and seven non-structural proteins. The NS4A
#=GF CC   protein is small and poorly conserved among the Flaviviruses.
#=GF CC   NS4A contains multiple hydrophobic potential membrane spanning
#=GF CC   regions [1].  NS4A has only been found in cells infected by
#=GF CC   Kunjin virus [2].
#=GF SQ   5
#=GS POLG_YEFV1/2111-2254    AC P03314.1
#=GS POLG_ZIKV/2120-2266     AC Q32ZE1.1
#=GS A0A0W0T013_9GAMM/15-79  AC A0A0W0T013.1
#=GS POLG_DEN1W/2099-2242    AC P17763.2
#=GS A0A1L7CYL6_9CORY/2-63   AC A0A1L7CYL6.1
POLG_YEFV1/2111-2254               .................EVLVVLSELPDFLAKKGGEAMDTISVFLHSEEGSRAYRNALSMMPEAMTIVMLFILAGLLTSGMVIFFMSPKGISRMSMAMGTMAG.CGYLMFLGGVKPTHISYVMLIFFVLMVVVIPEPGQQRSIQDNQVAYLI...IGILTLVSAV...
POLG_ZIKV/2120-2266                ...............gv--MEALGTLPGHMTERFQEAIDNLAVLMRAETGSRPYKAAAAQLPETLETIMLLGLLGTVSLGIFFVLMRNKGIGKMGFGMVTLGA.SAWLMWLSEIEPARIACVLIVVFLLLVVLIPEPEKQRSPQDNQMAIIImvaVGLLGLIT--an.
A0A0W0T013_9GAMM/15-79             tevvqtpspffasvfiy--------------------------------------------------------------------------------------.---------VEILSITIGVVLLFVAFYMLRPREEEQRRIQDQFLFYLI...LGLFLI----ffp
POLG_DEN1W/2099-2242               .................DLILEIGKLPQHLTQRAQNALDNLVMLHNSEQGGKAYRHAMEELPDTIETLMLLALIAVLTGGVTLFFLSGRGLGKTSIGLLCVIA.SSALLWMASVEPHWIAASIILEFFLMVLLIPEPDRQRTPQDNQLAYVV...IGLLFMI---lta
A0A1L7CYL6_9CORY/2-63              ...........laqasa------------------------------------------VGPNAAATYLLFIIAGLLVGGTYSVYKAGSRVGTIVMGVLAVIAlAGAILWLTG---------------------------------------...----------al.
#=GC seq_cons                      ................h..h..lupLPtahsp+htpAhDslshhhpuEpGu+sY+tAht.hP-shpTlMLhhLhGlLouGhhhhahus+GlG+huhGhlslhA.uuhLhWLuuVEPtpIuhslllhFlLhVlLIPEP-cQRo.QDNQlAYlI...lGLLhll...hh.
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