GenomeNet

Database: Pfam
Entry: PF05436
LinkDB: PF05436
Original site: PF05436 
#=GF ID   MF_alpha_N
#=GF AC   PF05436.12
#=GF DE   Mating factor alpha precursor N-terminus
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_12643 (release 8.0)
#=GF GA   21.90 21.90;
#=GF TC   22.30 22.00;
#=GF NC   21.40 21.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   6306574
#=GF RT   Saccharomyces cerevisiae contains two discrete genes coding for
#=GF RT   the alpha-factor pheromone. 
#=GF RA   Singh A, Chen EY, Lugovoy JM, Chang CN, Hitzeman RA, Seeburg PH; 
#=GF RL   Nucleic Acids Res 1983;11:4049-4063.
#=GF DR   INTERPRO; IPR008675;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family contains the N-terminal regions of the Saccharomyces
#=GF CC   mating factor alpha precursor protein. All proteins in this
#=GF CC   family contain one or more copies Pfam:PF04648 further toward
#=GF CC   their C terminus.
#=GF SQ   54
#=GS A0A367XUR3_9ASCO/1-88   AC A0A367XUR3.1
#=GS Q6CMM5_KLULA/1-86       AC Q6CMM5.1
#=GS A7TJ28_VANPO/1-95       AC A7TJ28.1
#=GS A0A1G4M9J1_LACFM/1-85   AC A0A1G4M9J1.1
#=GS G0WGY0_NAUDC/1-88       AC G0WGY0.1
#=GS A0A1E5RQF6_HANUV/1-88   AC A0A1E5RQF6.1
#=GS A7TE98_VANPO/1-92       AC A7TE98.1
#=GS A0A2P7YSY3_9ASCO/1-90   AC A0A2P7YSY3.1
#=GS A0A367YCE3_9ASCO/1-83   AC A0A367YCE3.1
#=GS A0A1G4MA35_LACFM/1-86   AC A0A1G4MA35.1
#=GS A0A1E3R110_9ASCO/1-94   AC A0A1E3R110.1
#=GS G0WCN5_NAUDC/1-93       AC G0WCN5.1
#=GS MFAL2_YEAST/1-81        AC P32435.1
#=GS Q59QG8_CANAL/1-87       AC Q59QG8.1
#=GS C4Y7V9_CLAL4/1-81       AC C4Y7V9.1
#=GS H2ARH5_KAZAF/1-84       AC H2ARH5.1
#=GS A0A1A0HI88_9ASCO/1-85   AC A0A1A0HI88.1
#=GS A0A367Y426_9ASCO/1-88   AC A0A367Y426.1
#=GS A0A1E5RDH2_9ASCO/1-90   AC A0A1E5RDH2.1
#=GS A0A1X7RBG5_9SACH/1-80   AC A0A1X7RBG5.1
#=GS Q6C5N6_YARLI/1-86       AC Q6C5N6.1
#=GS G0VEF5_NAUCC/1-90       AC G0VEF5.1
#=GS G8BYV1_TETPH/1-85       AC G8BYV1.1
#=GS G8JR13_ERECY/1-85       AC G8JR13.1
#=GS I2GYZ9_TETBL/1-89       AC I2GYZ9.1
#=GS A0A367YES7_9ASCO/1-88   AC A0A367YES7.1
#=GS J5PGN1_SACK1/1-73       AC J5PGN1.1
#=GS A0A1G4K5X1_9SACH/2-84   AC A0A1G4K5X1.1
#=GS F2Z659_CANGA/1-87       AC F2Z659.1
#=GS A0A0X8HTU0_9SACH/1-91   AC A0A0X8HTU0.1
#=GS G0VIT5_NAUCC/1-88       AC G0VIT5.1
#=GS A0A1L0DYC3_9ASCO/1-81   AC A0A1L0DYC3.1
#=GS G8ZYQ2_TORDC/1-80       AC G8ZYQ2.1
#=GS J5RMQ7_SACK1/1-85       AC J5RMQ7.1
#=GS A3LXF9_PICST/2-83       AC A3LXF9.1
#=GS A0A1E5RDY2_9ASCO/1-90   AC A0A1E5RDY2.1
#=GS C5E2G9_LACTC/2-84       AC C5E2G9.1
#=GS G0WFY2_NAUDC/1-97       AC G0WFY2.1
#=GS A0A2V1AN59_9ASCO/1-88   AC A0A2V1AN59.1
#=GS G8JP74_ERECY/1-86       AC G8JP74.1
#=GS MFAL1_YEAST/1-86        AC P01149.1
#=GS A0A1X7QZX3_9SACH/1-88   AC A0A1X7QZX3.1
#=GS G3AW19_CANTC/1-82       AC G3AW19.1
#=GS A0A2H1A6L9_CANAR/1-94   AC A0A2H1A6L9.1
#=GS Q75ED2_ASHGO/1-85       AC Q75ED2.1
#=GS W0TDC1_KLUMD/1-86       AC W0TDC1.1
#=GS A0A1A0HB32_9ASCO/1-83   AC A0A1A0HB32.1
#=GS Q754X8_ASHGO/1-93       AC Q754X8.1
#=GS A0A1G4JDW5_9SACH/1-88   AC A0A1G4JDW5.1
#=GS H2AS56_KAZAF/1-88       AC H2AS56.1
#=GS J7S8E5_KAZNA/1-86       AC J7S8E5.1
#=GS A0A0C7NEG7_9SACH/11-93  AC A0A0C7NEG7.1
#=GS A0A1G4J3L5_9SACH/3-91   AC A0A1G4J3L5.1
#=GS G0VKM8_NAUCC/1-86       AC G0VKM8.1
A0A367XUR3_9ASCO/1-88              .......MKFSL.A.LLT-TI...AAAL....VAAaptqAPVEDSDFSa........nETAVGIPENAVQAIIPLDGE--L.A.P.VFI..ELDDHP..AILIVNTTAAEETLS...---EAGVEKR-d...................................
Q6CMM5_KLULA/1-86                  .......MKFST.I.LAASTA...LISV....VMA....APVSTETDI.........dDLPISVPEEALIGFIDLTGD-EV.S.L.LPV..NNGTHT..GILFLNTTIAEAAFA...--DKDDLKKRE....................................
A7TJ28_VANPO/1-95                  .......MKFST.V.LSTVAL...AATA....VSA....APISRASNEtv.....esvESGLNVPAEAVLGYLDFGEKDDV.A.M.LPF..SNGTSN..GLLFVNTTIYDAAFAd.sDDESASLAKRD....................................
A0A1G4M9J1_LACFM/1-85              mqrllil-----.I.LGL-AS...TLMS....VSA....APLTDA---..........ASTVDIPQESILGVFEISDYDDI.A.L.LPV..SNGTHS..AVLILNATLIDAAGT...-SNSDEVEKR-s...................................
G0WGY0_NAUDC/1-88                  .......MKFTT.I.LSAITL...LSSS....AFA....EDISTGD--..........AELPQVPAEAVLGYLDFGSDNDI.A.M.LPF..ANTTSN..GLLFVNTTIVEQANEk.lENDPSSLTKRE....................................
A0A1E5RQF6_HANUV/1-88              .......MKFTT.A.IASVAA...AASF....ASA....AAIDQEQLT.........nGTYIDIPQESILSFLDLTDSPEV.S.V.YPI..KEGSKT..GLIFVNSTIVDQAYS...-ETTALTRKRE....................................
A7TE98_VANPO/1-92                  .......MKLTN.V.LSA-VA...LAST....ALA....APVAKDATNt.......tdASSVQIPAEAVIGYLDLEQSNDV.A.M.LQF..SNSTNN..GILFVNSTILKAAYAe.aNANSNSNTKRE....................................
A0A2P7YSY3_9ASCO/1-90              .......MKFST.T.AII-AA...AASL....VSA....APAPSPTVSavp....savESSFGVPTEAIIGQFSFDSDE--.Y.P.LSV..TYGDHR..YVILLNSTIMEQAYA...-S---------lpgdkhkre...........................
A0A367YCE3_9ASCO/1-83              .......MKFSL.A.LLA-TI...AAAL....VAA....APTETQAAT.........nETAVGIPENAVQAIIPLDGELSP.V.F.VEL..D--DHP..AILIVNATAAKETID...---ESGVEKR-d...................................
A0A1G4MA35_LACFM/1-86              .......MRLSS.L.VTA-TV...FFST....ALC....LPVRSTNPL..........PSGTSVPDEAILAFIDLTEDDDV.A.V.VRA..SNDTNS..GLLLVNTTLLAAMEH...-DHEAQAHKRD....................................
A0A1E3R110_9ASCO/1-94              .......MKLST.V.VTTTAL...VASV....ISA....VPANPTESSvpaa.tssaaENTINVPVEAINNAIYLASGE--.Y.P.LFI..EENGKP..MVLIVNATLAAQAEE...-EDADHLNKRD....................................
G0WCN5_NAUDC/1-93                  .......MKYSH.F.FNSLAL...LLSS...iSLI....SATQLIDDL.........tNSDGNIPTEAIIGYLDLGADSDV.T.L.LPF..SNNTAS..GLLFVNATILDQALAsseKSDNNGLSKR-a...................................
MFAL2_YEAST/1-81                   .......MKFIS.T.FLTFIL...AAVS....VTA....-----SSD-..........EDIAQVPAEAIIGYLDFGGDHDI.A.F.LPF..SNATAS..GLLFINTTIAEAAEK...-EQNTTLAKRE....................................
Q59QG8_CANAL/1-87                  .......MKFSL.T.LLT-AT...IATI....VAA....APAQYTGQAi.......dsNQVVEIPESAVEAYFPIDDE---.-.L.TPV..FGEIDNkpVILIVNGTTLTSGAN...NEKREA-----kskg................................
C4Y7V9_CLAL4/1-81                  .......MKFSL.A.IIF-SL...AAAV....VSA....APVAPES--..........SSDFQIPEEAIISSQALGDDQ-L.P.L.L-L..GEGNAT..YFVLVNGTTLAEAYG...-----------itkrdaeaf...........................
H2ARH5_KAZAF/1-84                  .......MKFTG.V.LSALSL...LSSA....VLA....ETESQST--..........-EAISVPSEAIIGYLDLDGANDV.A.I.IPL..VNTTDS..GLLFVNTTIYEQASN...-EDNVSLKKRE....................................
A0A1A0HI88_9ASCO/1-85              .......MKFST.P.LIF-GA...LTAL....VTA....APTPETDLT..........IDGTLVPSEAILGGLSIPDD--V.YpV.FNY..ENNTA-..TVVFLNATILADAKA...SNAE-------akrdlts.............................
A0A367Y426_9ASCO/1-88              .......MKFSL.A.LLTTIAaalVAAA....PAQ....APVEDSDVSa........nETAVGIPENAVQAIIPLDGE--L.A.P.VFI..ELDDHP..AILIVNTTAAEETLS...---EAGVEKR-d...................................
A0A1E5RDH2_9ASCO/1-90              .......MKLST.T.IAATTA...ATTAlvagATA....APVSGASN-..........STSMEVPGEAVKYFLDLSDSPDM.A.L.VPI..NNGNTT..GIMFVNTTVIDQAYA...-ETTSLSRKR-e...................................
A0A1X7RBG5_9SACH/1-80              .......MQFST.I.LSTLAL...SVAT....VLA....EETNTT---..........----SIPAEAIIGYMALGSDKDV.G.I.IPF..GNATSN..GLMFINTTIAKEAAL...-SKDSDLAKRE....................................
Q6C5N6_YARLI/1-86                  .......MKFST.IaLAAVAC...LVSA....APA....APVGTGS--..........HGPQSIPEEAIVGGLQGTEN-EI.F.VfFND..DESGKQ..GIAI-----------...-----------idakkaqeagfmdpqpdseva...............
G0VEF5_NAUCC/1-90                  .......MKLSA.L.LST-VA...LAST....SFA....APIDTTASNe........nLNSTDIPAEAVIGYLDLGSDSDV.A.M.LPF..QNSTSN..GLLFVNTTIVQQAAQ..eNDDSVGLAKRE....................................
G8BYV1_TETPH/1-85                  .......MKLSS.V.LSTLAL...TATS....AFA....APVSNES--..........VDNASVPAEAIIGYLNFDGANDI.A.L.LPF..SNSTTS..GVMFINTTIAEQAYE...-EAGVSLSKRE....................................
G8JR13_ERECY/1-85                  .......MKLSS.L.LPI-LA...AATT....AIA....APVQTQGA-..........ESHLNIPQEAVLGFIDLGNGNDI.Q.V.TTI..LNGTQN..GILLFNSTVANAAAA...-PSDSTLAKRD....................................
I2GYZ9_TETBL/1-89                  .......MKFST.V.LSLVSV...AAST....TLA....APVDTESLYd........nSTTVDVPEEAILAFVGFDGT-DV.A.L.TPF..RNETHS..GVLFINTTIYESALA...SEDGTPLVKRE....................................
A0A367YES7_9ASCO/1-88              .......MKFSL.A.LLT-TI...AAAL....VAA....APTETQAATaet....atnETAVGIPENAVQAIIPLDGELSP.V.F.VEL..D--DHP..AILIVNTTAAQETID...---ESGVEKR-d...................................
J5PGN1_SACK1/1-73                  ..mtila-----.-.------...----....--A....TSVFASS-N..........DDIVQVPAEAVIGYLDLGRDHDI.A.A.LPF..SNSTTS..GLLFVNTTIVNVAEK...-KRNATLTKRD....................................
A0A1G4K5X1_9SACH/2-84              ....yqt---IN.V.CLALTL...AVTN....VCA....APIKFND--..........-SSPALPLESISGYLDLTGAEDL.A.L.LPV..SNATHT..GILVVNTTILASALA...--SESNYNKR-d...................................
F2Z659_CANGA/1-87                  .......MRFLR.F.ISTVAL...LITG...lATA....QPVGEEL--..........GETVEVPSEAFIGYLDFGATNDV.A.I.LPI..SNKTNN..GLLFVNTTLYNQATK...GEKLSDFTKRD....................................
A0A0X8HTU0_9SACH/1-91              .......MRLNS.I.VCA-FG...VAAL....ASA....APVDINLKAatqh..dfpkGENFGLPEESILGFIDLAKDKDV.S.V.LQV..K----E..GLLFLNSTVLQNSNI...EINGSSIEKRD....................................
G0VIT5_NAUCC/1-88                  .......MQLAS.I.ILA-FL...IASF...fSIA....VPIQLSDNL.........aNSRQEIPKEAVIGYLDFGSQRDI.T.L.LPF..ANSTTS..GLLFANSTLLEQASV...-GNNRTLLKRE....................................
A0A1L0DYC3_9ASCO/1-81              .......MKFIN.A.LLL-SL...AASV....VSA....APAATPVD-..........DGSVSVPTEAILGRIDLNPEEFP.Y.-.-IV..SDGENT..SIVLFNTTILDEAYS...-----G-----vtkrdae.............................
G8ZYQ2_TORDC/1-80                  .......MKFFNtI.LST-TL...FTYV....ALA....APVESDP--..........---VNIPSEAILGYMDFTEDQDV.G.V.VAY..TNSTFS..GLIFFNSSIIETKD-...-----------ltkrdaeag...........................
J5RMQ7_SACK1/1-85                  .......MRFSS.I.ITA-VF...AASS....ALA....APVNTTSE-..........SETVQIPAEAIIGYLDLEGDFDV.A.V.LPF..ANSTNN..GLLFINTTIANLATK...-EESVPLSKRE....................................
A3LXF9_PICST/2-83                  ....hlr--STA.I.LSA-VV...FTSV....ALS....APTSGQN--..........-IDIDFPDESIAGAIPLSYD---.-.L.VPIigSYQGQN..VILIVNSTIAAASEA...-AASEGKSKRD....................................
A0A1E5RDY2_9ASCO/1-90              .......MKLST.T.IAATTA...ATTAlvagATA....APVSGASN-..........STSMEVPGEAVKYFLDLSDSPDM.A.L.VPI..NNGNTT..GIMFVNTTVIDQAYA...-EXTSLSRK--re..................................
C5E2G9_LACTC/2-84                  ....lks---FS.L.FLAFAL...TSIT....VSA....APINITD--..........-SDPVIPRESICGFLDLTDAEDL.A.L.LPV..SNGTHS..GILVVNTTILAQAFG...--SDDILTKR-d...................................
G0WFY2_NAUDC/1-97                  .......MKFST.L.LSTAAA...LAST....SLA....APINTTETIdn.....ssaATSADIPAEAILGYLDLDGDNDI.A.L.LPF..ANATSN..GLLFVNTTIVEQATK...EQQN-------gdgsvdltkre.........................
A0A2V1AN59_9ASCO/1-88              .......MKFSA.T.AII-AA...AASI....VAA....APAPTTTEVpt......avESAFGVPTEAIIGQFSFDSD-EY.P.L.LTT..YG-DRR..YVILLNSTIMEEAYA...-SLSDDKTKR-d...................................
G8JP74_ERECY/1-86                  .......MKFYN.I.LSV-AS...IASL....VFA....APVSVNDAK..........EIAATFPQEALLGFLDLTDAENI.V.I.LSL..VDEEKS..GIALVNKTIWATARS...-EQAAGISKRD....................................
MFAL1_YEAST/1-86                   .......MRFPS.I.FTAVLF...AASS....ALA....APVNTTTE-..........DETAQIPAEAVIGYLDLEGDFDV.A.V.LPF..SNSTNN..GLLFINTTIASIAAK...-EEGVSLDKRE....................................
A0A1X7QZX3_9SACH/1-88              .......MKFVN.T.LSLLAT...VAV-....TLA....APVNITETS.........eTSKATIPAEAIIGYLDLEGNKDV.A.L.LPF..HNETSN..GLMFVNTTIINSALA...ETEDEDLVKRE....................................
G3AW19_CANTC/1-82                  .......MRLST.I.LTL-AL...TSKF....VFS....APVEKVKR-..........EDGLDVPDEAIIAVYPIDEY---.-.-.---..------..---------------...-----------kqpfyaeadgqnyvvilnttalgeadlakrdadafs
A0A2H1A6L9_CANAR/1-94              .......MKFS-.I.TAIIAA...TGSL....VAA....APTPSSTDApsfsevpssvESSFGVPTEAIIGQFSFDAD-EY.P.L.LTV..YEDRR-..YIILLNSTIMEEAYA...-SLNSGNEKRD....................................
Q75ED2_ASHGO/1-85                  .......MKTTH.I.LSLATL...AACA...pVQP....APVQPTDL-..........AAAANVPEKAVLGFFQLYNVGDV.E.L.LPV..DDGAHS..GILFVNRTLADVDYS...SE---------hvvqkw..............................
W0TDC1_KLUMD/1-86                  .......MRLSA.V.FVSAIA...LLST....VIA....APITEKESD..........DSSIKVPSEAILGFLDLTADDDV.G.L.VKI..NNGTHS..GILFLNTTIASIAYA...--NETILSKRE....................................
A0A1A0HB32_9ASCO/1-83              .mklsip-----.-.--LIFG...AITV....ASA....SPASEANLT..........INGTLIPQEAIISGLTIPED--VyP.I.LNY..ENNTAT..-VVFLNGTLLAEAKA...YNS--------etkrdva.............................
Q754X8_ASHGO/1-93                  .......MKISL.L.FSV-SA...LLGA....VIA....IPVNGSRPEvt......idDVRGNIPEDAVLGFLDLSDVEGL.A.V.RPI..QTEERT..GLLFVNRQLAEKGTE...AASS-------qgspklekd...........................
A0A1G4JDW5_9SACH/1-88              mkltvfw---TA.F.LSFLTT...FIVT....ASA....APVADSAN-..........DGSVNIPAESIIGFLDLSDSKDA.T.L.VPV..SNGTHS..GFLFLNSTILSQAST...----ESLKKR-sa..................................
H2AS56_KAZAF/1-88                  .......MKFST.I.LSTAAF...VSSS....VMA....APVNVTETE..........QENLAIPSEALIGYLDLKGDDDI.S.I.LPV..SNSTNS..GLLFLNSTILTQAMN...ENTEAALSKRE....................................
J7S8E5_KAZNA/1-86                  .......MKFST.I.LSA-AA...LAAS....AFA....APIEQPEQD..........LNSTTIPAEAIISYLDLEGDKDI.A.V.VPF..SNATDS..GLLFVNTTILAQANK...-EAGTPLQKRE....................................
A0A0C7NEG7_9SACH/11-93             fkrlsiy-----.-.-LA-LA...LANV....SMA....APITTND--..........-SLPAIPQESISGYLDLTGADDL.A.L.LPV..SNDTHT..GILVVNTTILASALA...--SVSQHSKR-ea..................................
A0A1G4J3L5_9SACH/3-91              ....ref---SA.Y.LTL-AL...AMSR....AWA....APVNLSSSLs........mNEGQSLPAESIVGFLDLTGADDL.A.L.FPV..SNATNT..GVLIVNTTVLDSATE...-SKK-------rgkrnana............................
G0VKM8_NAUCC/1-86                  .......MKFSS.I.LSTIAL...FSAS....TLA....TDIETED--..........ATMPQVPAEAVIGYLDFDGDNDI.A.M.LPF..ANATSS..GLLFVNTTLVEQANN...EEGSISLAKRE....................................
#=GC seq_cons                      .......MKhos.h.lss.sh...huos....shA....APlssss............tsssslPsEAllGalDLssspDl.u.l.lPh..sNsTps..GlLhlNoTlhppAhs....pppsshtKR.....................................
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