#=GF ID VirArc_Nuclease
#=GF AC PF12187.12
#=GF DE Viral/Archaeal nuclease
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Gavin OL;
#=GF SE pdb_2w8m
#=GF GA 20.10 20.10;
#=GF TC 20.60 20.60;
#=GF NC 19.50 20.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0236
#=GF RN [1]
#=GF RM 22638584
#=GF RT Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT phosphodiesterase superfamily.
#=GF RA Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA K;
#=GF RL Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR INTERPRO; IPR022012;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family of proteins is found in archaea and viruses.
#=GF CC Proteins in this family are typically between 211 and 244 amino
#=GF CC acids in length. These proteins are nucleases from
#=GF CC fusseloviruses and sulfolobus archaea.
#=GF SQ 15
#=GS A8TKH6_9VIRU/3-190 AC A8TKH6.1
#=GS A0A1S5WVI3_9VIRU/13-192 AC A0A1S5WVI3.1
#=GS Q97ZN3_SACS2/12-138 AC Q97ZN3.1
#=GS A5DEJ3_PICGU/65-153 AC A5DEJ3.2
#=GS A0A7L4XPN2_9VIRU/6-194 AC A0A7L4XPN2.1
#=GS A0A2Z5WQ14_9VIRU/22-175 AC A0A2Z5WQ14.1
#=GS Q6TRV5_9VIRU/5-194 AC Q6TRV5.1
#=GS H2C868_9CREN/5-194 AC H2C868.1
#=GS Q4JBE8_SULAC/4-198 AC Q4JBE8.1
#=GS D244_SSV1/37-226 AC P20213.1
#=GS D1GF28_9VIRU/4-193 AC D1GF28.1
#=GS A0A421JDV4_9ASCO/98-185 AC A0A421JDV4.1
#=GS D1AG86_SEBTE/5-158 AC D1AG86.1
#=GS Q6UG84_SSV2/3-192 AC Q6UG84.1
#=GS A0A1S5WVL7_9VIRU/2-189 AC A0A1S5WVL7.1
A8TKH6_9VIRU/3-190 ..................................DFKLKYWGDQS.EDYILPTTWLGREYLVLGKL.IIKLAKWRK--YLDFDVYIRRSGVGTLTNTINYEYYK.GLEDKYDLTLYVKAK....QQYYP..LIWLDITGSSWTEEQSKER.....YGES...VYAILSIKLEVAKKYD..VMG.RVWFIHYNDTEDKLKCINALQILNLERENK...IKKDKFERDAKSEYYLIPVSMWKNLTELRV...............................
A0A1S5WVI3_9VIRU/13-192 sfantlkdkyaklwtlttirediarkwlmltlnl-----------.--------------------.------------SENDIVV--NGIGVLSDEKTDDTWEgDPKKKYDF--YI---....PKY--..NMYIDITGTQFTKRQSSSRlhgmdLKGS...YVAVLGVKHAVGLVLQqyYKA.KAVIANIADNEGEIRFITVDYITLLKKKG-...IAISTKEFAKGENEYI--LIPWKEFWK---psrfkn.........................
Q97ZN3_SACS2/12-138 ......................rtwegdpfkkfd-----------.--------------------.-------------------------------------.---------------....-FYIPkyNLYLDVTGTSFTKSESIKRahmlqLRGA...IIAILGIKVSVAEILA..AKGyRTAFANVAEREGEIRFMPYSRLKVLEKNGRaiiAQPEEIEFAKGERTYI--LTRWTDWLKPNQ...............................
A5DEJ3_PICGU/65-153 ...........................klpefgp-----------.--YNLDYSRNGRELLLVGKKgHIASLDWR-KGAISSEHYVNET-CHAIKSLHNDQYYA.VAQKKYTF-IYDKTG....TEL--..-------------------.....----...----------------..---.------------------------------...------------------------------hrlkqhieatl....................
A0A7L4XPN2_9VIRU/6-194 .................................s-FKLKYWGNSE.DGLLKINPYTGRELEFLGKL.MKKLSL-----HIKYDLYIMPSGIGTLDTSLLPNYYH.DVSDKYDFTIFTLVNlngkKVKWP..VVYIDVTGSKYSDKESEER.....YGKP...VDAILKTKVDVAFKYS..VAG.RVYFVLSIDKEDKFRVLTALQVMNLYKKGI...AKLDSFEEGGKTPYYLIPRDQWKPFKEL--iv.............................
A0A2Z5WQ14_9VIRU/22-175 ...............snareqfvlaalqaylppg-----------.--------------------.----------------FEARLTGLGAGSSEYIEHNYK.SLEEAFDITVYYMDR....----P..VAFLDVTGVVSVLN--ARR.....AACN...GRCVGSWKLRKAEKHR..VLG.RVWFAWVNDQTASIYFLPAAWLAQHAEGPH...VSKCRLYSD-ERIVYCVRPGYWKKL-----ynfl...........................
Q6TRV5_9VIRU/5-194 ..................................DFKLKYWGNQE.QDYILPTVGLGREYLVLGKL.LISLSKWRAKGLIDFDVYLRPTGVGTLTNTINYEYYK.GLEDKYDLTLYIRAK....DSYYP..LLWIDITGSSWTEEQSKER.....YGES...IYAILSVKVETAKKYD..VLG.RVFFIHYNDTEDKLKCISALQILNLERQNK...IKKDKFERGAKSEYYLIPTSYWKNLTELR-i..............................
H2C868_9CREN/5-194 .................................s-FKLKYWGNQQ.EDYILPTAGLGREYLVLGKL.LIKLAQWHKKGLLNFDVYLRPTGVGTLTNVINEQYYK.GLDDKYDLTLYVKSK....EQYYP..LLWIDITGSSWTEEQSKER.....YGES...VYAILSVKVETAKKYN..VLG.RVFFLHYSDAEDKLKCISALQILNLERQNK...IKKDKFERDAKSEYYLIPLEYWKNLMELRV...............................
Q4JBE8_SULAC/4-198 ..................................DFKQRYWANSNfDGFEVPNEHLGREYLIYGLL.HIKLKQWKEKGLIPDNIYLRRTGIGTLTSVINHDYYK.DVLDKYDFTIYYHYKengeDRYWP..GLFIDTTGSSWTEEQSEQR.....YGEP...IYAVLSTKVWVAQEFD..VLG.RTIFIHYNDREDKLKLIVALSILNLYGQNK...IRLNEYEYGAKSQYYIIPVKFWKNITELRV...............................
D244_SSV1/37-226 ..................................NFKLKYWGNQA.EDYILPSTYLGREYLVFGKL.LISLSKWRAKGLLDFDVYIRPTGVGTLTNVINEQYYS.GLQDKYDLTLYVKAK....TEYYP..LIWIDITGSSWTEEQSKER.....YGES...VYAILSTKVEVAKQNE..VMG.RVWFIHYSDAEDKLKCISALQILNLEKQGK...IKKDKFERDAVSYYYLIPLQYWKNLTDLRV...............................
D1GF28_9VIRU/4-193 .................................s-FKLKYWGNQT.EDYILPNFYLGREYLVLGKL.LIKLAQWRKKGLLDFDIYLRPTGVGTLTNVINFEHYE.GLQDKYDLTLYVKAK....DSYYS..LAWIDITGSSWTEEQSKER.....YGES...IYAILSTKIEIAKKYD..VLG.RVFFIHYNDTEDKLKCISALQILNLERQNK...IKKDKFERDAVSYYYLIPTSYWKNLTELRV...............................
A0A421JDV4_9ASCO/98-185 ...........................klpefgp-----------.--YNLDYSRNGRELLLVGKKgHIASLDWR-KGAISSEHYVNET-CHAIKSLHNDQYYA.VAQKKYTF-IYDKTG....TEL--..-------------------.....----...----------------..---.------------------------------...------------------------------hrlkqhieat.....................
D1AG86_SEBTE/5-158 ....................fffllfssyfscsl-----------.--------------------.-----------LNDPDFYMRKAFETTRETQLEDKLYC.DRNDKYMI--YYYKD....SKYLQ..IGLVDKLQKKENYGDVIKR.....LQEDsaiIYDVFKQKIIVSNRAN..NFN.GVEFRHYLDIDDTVFMLNKL----------...------------------------------vvdpdgevqmlinsqlrelfnnsntfyytdd
Q6UG84_SSV2/3-192 ..................................DFKLKYWGNQT.EDYILPNFYLGREYLVLGKL.LIKLAQWRVKGLIDFDVFVKITGVGTLTNVINEHYYE.GLQDKYDLTLYVKAK....DSYYP..LVWIDITGSSWTEEQSKER.....YGES...VYAILSAKVEVAIKHD..VMG.RVWFIHYNDTEDKLKCISALQILNLERQGK...IKKDKFERDAKSEYYLIPVSMWKNLVELRV...............................
A0A1S5WVL7_9VIRU/2-189 .................................s-FKLKYWGNQQ.EDYILPNVWLGREYLVLGKL.IIKLAKWRK--YLDFDVYIRRSGVGTLTNTINYEYYK.GLEDKYDLTLYVKAK....DSYYP..LVWIDITGSSWTEEQSKER.....YGES...VYAILSIKLEVAKKYD..VMG.RVWFIHYNDTEDKLKCISALQILNLERQNK...IKKDKFERDAKSEYYLIPVSVWKNLVELRV...............................
#=GC seq_cons ...................................FK.+YWuspt.psY.Lss.hhGREhLllGKL.hIpLtpW+...hlc.DlYlR.TGlGTLosslNccYYc.slpDKYDlTlYs+s+....spYaP..llaIDlTGSSaT-cQSccR.....YGEu...lYAILShKlcVAp+as..VhG.RVaFlHYsDpEDKl+hIsALpIhNLc+ps+...I+h-caEpsuto.YYlIPhphWKslh-Lp................................
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