#=GF ID   VirArc_Nuclease
#=GF AC   PF12187.12
#=GF DE   Viral/Archaeal nuclease
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_2w8m
#=GF GA   20.10 20.10;
#=GF TC   20.60 20.60;
#=GF NC   19.50 20.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR022012;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This family of proteins is found in archaea and viruses.
#=GF CC   Proteins in this family are typically between 211 and 244 amino
#=GF CC   acids in length. These proteins are nucleases from
#=GF CC   fusseloviruses and sulfolobus archaea.
#=GF SQ   15
#=GS A8TKH6_9VIRU/3-190       AC A8TKH6.1
#=GS A0A1S5WVI3_9VIRU/13-192  AC A0A1S5WVI3.1
#=GS Q97ZN3_SACS2/12-138      AC Q97ZN3.1
#=GS A5DEJ3_PICGU/65-153      AC A5DEJ3.2
#=GS A0A7L4XPN2_9VIRU/6-194   AC A0A7L4XPN2.1
#=GS A0A2Z5WQ14_9VIRU/22-175  AC A0A2Z5WQ14.1
#=GS Q6TRV5_9VIRU/5-194       AC Q6TRV5.1
#=GS H2C868_9CREN/5-194       AC H2C868.1
#=GS Q4JBE8_SULAC/4-198       AC Q4JBE8.1
#=GS D244_SSV1/37-226         AC P20213.1
#=GS D1GF28_9VIRU/4-193       AC D1GF28.1
#=GS A0A421JDV4_9ASCO/98-185  AC A0A421JDV4.1
#=GS D1AG86_SEBTE/5-158       AC D1AG86.1
#=GS Q6UG84_SSV2/3-192        AC Q6UG84.1
#=GS A0A1S5WVL7_9VIRU/2-189   AC A0A1S5WVL7.1
A8TKH6_9VIRU/3-190                  ..................................DFKLKYWGDQS.EDYILPTTWLGREYLVLGKL.IIKLAKWRK--YLDFDVYIRRSGVGTLTNTINYEYYK.GLEDKYDLTLYVKAK....QQYYP..LIWLDITGSSWTEEQSKER.....YGES...VYAILSIKLEVAKKYD..VMG.RVWFIHYNDTEDKLKCINALQILNLERENK...IKKDKFERDAKSEYYLIPVSMWKNLTELRV...............................
A0A1S5WVI3_9VIRU/13-192             sfantlkdkyaklwtlttirediarkwlmltlnl-----------.--------------------.------------SENDIVV--NGIGVLSDEKTDDTWEgDPKKKYDF--YI---....PKY--..NMYIDITGTQFTKRQSSSRlhgmdLKGS...YVAVLGVKHAVGLVLQqyYKA.KAVIANIADNEGEIRFITVDYITLLKKKG-...IAISTKEFAKGENEYI--LIPWKEFWK---psrfkn.........................
Q97ZN3_SACS2/12-138                 ......................rtwegdpfkkfd-----------.--------------------.-------------------------------------.---------------....-FYIPkyNLYLDVTGTSFTKSESIKRahmlqLRGA...IIAILGIKVSVAEILA..AKGyRTAFANVAEREGEIRFMPYSRLKVLEKNGRaiiAQPEEIEFAKGERTYI--LTRWTDWLKPNQ...............................
A5DEJ3_PICGU/65-153                 ...........................klpefgp-----------.--YNLDYSRNGRELLLVGKKgHIASLDWR-KGAISSEHYVNET-CHAIKSLHNDQYYA.VAQKKYTF-IYDKTG....TEL--..-------------------.....----...----------------..---.------------------------------...------------------------------hrlkqhieatl....................
A0A7L4XPN2_9VIRU/6-194              .................................s-FKLKYWGNSE.DGLLKINPYTGRELEFLGKL.MKKLSL-----HIKYDLYIMPSGIGTLDTSLLPNYYH.DVSDKYDFTIFTLVNlngkKVKWP..VVYIDVTGSKYSDKESEER.....YGKP...VDAILKTKVDVAFKYS..VAG.RVYFVLSIDKEDKFRVLTALQVMNLYKKGI...AKLDSFEEGGKTPYYLIPRDQWKPFKEL--iv.............................
A0A2Z5WQ14_9VIRU/22-175             ...............snareqfvlaalqaylppg-----------.--------------------.----------------FEARLTGLGAGSSEYIEHNYK.SLEEAFDITVYYMDR....----P..VAFLDVTGVVSVLN--ARR.....AACN...GRCVGSWKLRKAEKHR..VLG.RVWFAWVNDQTASIYFLPAAWLAQHAEGPH...VSKCRLYSD-ERIVYCVRPGYWKKL-----ynfl...........................
Q6TRV5_9VIRU/5-194                  ..................................DFKLKYWGNQE.QDYILPTVGLGREYLVLGKL.LISLSKWRAKGLIDFDVYLRPTGVGTLTNTINYEYYK.GLEDKYDLTLYIRAK....DSYYP..LLWIDITGSSWTEEQSKER.....YGES...IYAILSVKVETAKKYD..VLG.RVFFIHYNDTEDKLKCISALQILNLERQNK...IKKDKFERGAKSEYYLIPTSYWKNLTELR-i..............................
H2C868_9CREN/5-194                  .................................s-FKLKYWGNQQ.EDYILPTAGLGREYLVLGKL.LIKLAQWHKKGLLNFDVYLRPTGVGTLTNVINEQYYK.GLDDKYDLTLYVKSK....EQYYP..LLWIDITGSSWTEEQSKER.....YGES...VYAILSVKVETAKKYN..VLG.RVFFLHYSDAEDKLKCISALQILNLERQNK...IKKDKFERDAKSEYYLIPLEYWKNLMELRV...............................
Q4JBE8_SULAC/4-198                  ..................................DFKQRYWANSNfDGFEVPNEHLGREYLIYGLL.HIKLKQWKEKGLIPDNIYLRRTGIGTLTSVINHDYYK.DVLDKYDFTIYYHYKengeDRYWP..GLFIDTTGSSWTEEQSEQR.....YGEP...IYAVLSTKVWVAQEFD..VLG.RTIFIHYNDREDKLKLIVALSILNLYGQNK...IRLNEYEYGAKSQYYIIPVKFWKNITELRV...............................
D244_SSV1/37-226                    ..................................NFKLKYWGNQA.EDYILPSTYLGREYLVFGKL.LISLSKWRAKGLLDFDVYIRPTGVGTLTNVINEQYYS.GLQDKYDLTLYVKAK....TEYYP..LIWIDITGSSWTEEQSKER.....YGES...VYAILSTKVEVAKQNE..VMG.RVWFIHYSDAEDKLKCISALQILNLEKQGK...IKKDKFERDAVSYYYLIPLQYWKNLTDLRV...............................
D1GF28_9VIRU/4-193                  .................................s-FKLKYWGNQT.EDYILPNFYLGREYLVLGKL.LIKLAQWRKKGLLDFDIYLRPTGVGTLTNVINFEHYE.GLQDKYDLTLYVKAK....DSYYS..LAWIDITGSSWTEEQSKER.....YGES...IYAILSTKIEIAKKYD..VLG.RVFFIHYNDTEDKLKCISALQILNLERQNK...IKKDKFERDAVSYYYLIPTSYWKNLTELRV...............................
A0A421JDV4_9ASCO/98-185             ...........................klpefgp-----------.--YNLDYSRNGRELLLVGKKgHIASLDWR-KGAISSEHYVNET-CHAIKSLHNDQYYA.VAQKKYTF-IYDKTG....TEL--..-------------------.....----...----------------..---.------------------------------...------------------------------hrlkqhieat.....................
D1AG86_SEBTE/5-158                  ....................fffllfssyfscsl-----------.--------------------.-----------LNDPDFYMRKAFETTRETQLEDKLYC.DRNDKYMI--YYYKD....SKYLQ..IGLVDKLQKKENYGDVIKR.....LQEDsaiIYDVFKQKIIVSNRAN..NFN.GVEFRHYLDIDDTVFMLNKL----------...------------------------------vvdpdgevqmlinsqlrelfnnsntfyytdd
Q6UG84_SSV2/3-192                   ..................................DFKLKYWGNQT.EDYILPNFYLGREYLVLGKL.LIKLAQWRVKGLIDFDVFVKITGVGTLTNVINEHYYE.GLQDKYDLTLYVKAK....DSYYP..LVWIDITGSSWTEEQSKER.....YGES...VYAILSAKVEVAIKHD..VMG.RVWFIHYNDTEDKLKCISALQILNLERQGK...IKKDKFERDAKSEYYLIPVSMWKNLVELRV...............................
A0A1S5WVL7_9VIRU/2-189              .................................s-FKLKYWGNQQ.EDYILPNVWLGREYLVLGKL.IIKLAKWRK--YLDFDVYIRRSGVGTLTNTINYEYYK.GLEDKYDLTLYVKAK....DSYYP..LVWIDITGSSWTEEQSKER.....YGES...VYAILSIKLEVAKKYD..VMG.RVWFIHYNDTEDKLKCISALQILNLERQNK...IKKDKFERDAKSEYYLIPVSVWKNLVELRV...............................
#=GC seq_cons                       ...................................FK.+YWuspt.psY.Lss.hhGREhLllGKL.hIpLtpW+...hlc.DlYlR.TGlGTLosslNccYYc.slpDKYDlTlYs+s+....spYaP..llaIDlTGSSaT-cQSccR.....YGEu...lYAILShKlcVAp+as..VhG.RVaFlHYsDpEDKl+hIsALpIhNLc+ps+...I+h-caEpsuto.YYlIPhphWKslh-Lp................................
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