GenomeNet

Database: Pfam
Entry: PF14263
LinkDB: PF14263
Original site: PF14263 
#=GF ID   DUF4354
#=GF AC   PF14263.7
#=GF DE   Domain of unknown function (DUF4354)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   JCSG:Target416839_SP17692A
#=GF GA   25.50 25.50;
#=GF TC   25.90 25.50;
#=GF NC   25.30 25.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR025581;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Several members of this family are annotated as being
#=GF CC   ATP/GTP-binding site motif A (P-loop) proteins, but this could
#=GF CC   not be confirmed. The one PDB:3NRF structure solved for this
#=GF CC   family exhibits an immunoglobin-like beta-sandwich fold. 
#=GF CC   Crystal packing suggests that a tetramer is a significant
#=GF CC   oligomerisation state, and a disulfide bridge is formed between
#=GF CC   Cys 125 at the C-terminal end of the monomer, and Cys 69.
#=GF SQ   28
#=GS A0A2V3U6U9_9RHIZ/1-123   AC A0A2V3U6U9.1
#=GS A0A2I0FUH6_9GAMM/1-123   AC A0A2I0FUH6.1
#=GS L0EUW8_LIBCB/1-121       AC L0EUW8.1
#=GS B2VCP2_ERWT9/1-118       AC B2VCP2.1
#=GS A0A2X5EVD7_SERRU/1-123   AC A0A2X5EVD7.1
#=GS A0A2A2HQF3_9GAMM/1-123   AC A0A2A2HQF3.1
#=GS A0A2S9I6N8_9GAMM/23-149  AC A0A2S9I6N8.1
#=GS D3V905_XENNA/1-123       AC D3V905.1
#=GS A0A2A2GVA1_9GAMM/1-65    AC A0A2A2GVA1.1
#=GS Q2YR31_BRUA2/1-111       AC Q2YR31.1
#=GS Q11IS2_CHESB/1-120       AC Q11IS2.1
#=GS A0A348HI30_9GAMM/2-125   AC A0A348HI30.1
#=GS A0A0H5M036_YERIN/1-125   AC A0A0H5M036.1
#=GS Q9I2H0_PSEAE/1-123       AC Q9I2H0.1
#=GS Q9I2H0_PSEAE/1-123       DR PDB; 3NRF B; 23-123;
#=GS Q9I2H0_PSEAE/1-123       DR PDB; 3NRF A; 25-123;
#=GS Q9I2H0_PSEAE/1-123       DR PDB; 3SB3 A; 25-123;
#=GS A0A0F5FHI2_9RHIZ/1-119   AC A0A0F5FHI2.1
#=GS A0A0Q4MHG1_9GAMM/1-123   AC A0A0Q4MHG1.1
#=GS A0A1Y3FXR1_9PROT/1-124   AC A0A1Y3FXR1.1
#=GS C4K5R4_HAMD5/1-123       AC C4K5R4.1
#=GS Q2NPZ4_SODGM/1-56        AC Q2NPZ4.1
#=GS A0A3D8TTF0_9LIST/31-139  AC A0A3D8TTF0.1
#=GS A0A366DXJ7_9RHIZ/4-127   AC A0A366DXJ7.1
#=GS A0A0N1KIM1_9GAMM/1-126   AC A0A0N1KIM1.1
#=GS S3J1Z3_9ENTR/1-123       AC S3J1Z3.1
#=GS W1JCY7_9GAMM/1-123       AC W1JCY7.1
#=GS A0A0H5LS11_YERIN/1-123   AC A0A0H5LS11.1
#=GS A0A0J9BH82_9GAMM/1-122   AC A0A0J9BH82.1
#=GS D8MW40_ERWBE/1-120       AC D8MW40.1
#=GS A0A2X3GN76_9LIST/29-140  AC A0A2X3GN76.1
A0A2V3U6U9_9RHIZ/1-123              .............................MRK.IFISVFSIITLIAF..G.A--QASPLNNVILLASPADTTTKSYLGKFTYLKKFQIALANVSETAIDLR..N..ACYLLIGNNGQTYHVDTMEDTVSGGKLEPGKSVNGFVVFAGADEDIFLQSKV----iian.....
A0A2I0FUH6_9GAMM/1-123              ......................mksshvf---.------IVLAMLAS..S.FSVSAKAPADIAVFATEKSQGSMSIGDNSAYTRTFEVTLANLADKSIDLS..K..RCLKAYLHDKTELQLDTLDEKLMTNTLAAGTSIKGIAVFSSTNENIFSAAQVKISE.........
L0EUW8_LIBCB/1-121                  .............................MKK.---SYLLLYPICFL..F.SIAASSVPPEVIVYAKQKETGSIFSPHKFTYTKDFDVTVVNFSQGEIDLS..K..YCFKAM-LGMKEFNVDTIDEKLASKKLKNGERLRGVVVFSSNNSDVTQANIVQLTD.........
B2VCP2_ERWT9/1-118                  ............................m---.--AASVTVAGFCSV..A.H---AAVPDNAAVYATEHSKGSMSIAGKDVYTKTFEVMVANLADKEFDLS..T..LCLKAVAPDHQEFKLDTVDEKLTTGKVKKGQSVKGIAVFASDNAAVQQTALVKLTD.........
A0A2X5EVD7_SERRU/1-123              .............................MKIsTMVASLALAGFCFA..A.N---AATPGNIAVYATEKSTGSISIGGKDAYTKTFDVALAKLSGDDIDLS..T..LCLKAYSPDNKAFKLDTVDEALTTGTLKDGKLVKGIAVFAADNAAVYNAALVKITD.........
A0A2A2HQF3_9GAMM/1-123              .............................MKGkILLTALAFSSVSMI..A.S---AVETDNLVVYSTQQDKGATSLGNQAFYTKSFDVTLANVGDKDADLS..K..FCLKAYNKHGKTFKLDTIEETLTTGNLLPKKTVKGMAVFASNDESVYDASIVKLS-y........
A0A2S9I6N8_9GAMM/23-149             .......................mqrnsl---.-IAILIATAGLYFS..S.AAFADSVPKGLTVYATEKEQTSRSEGDLNNYGKTFEVTLENLTPNSVDLN..S..ICLRGYSHEGKEFPVARVQEALTKGKLKPQKKVTGLAVFSAADDSVFDVNQLKI--ah.......
D3V905_XENNA/1-123                  .............................MKVsTFVASIALAGFCFV..A.N---ASTLDRVAVYSTEKSNGSVSVGGKNAYTKSFEVAVANLSDKDIDLS..K..LCLKAYSPDKKEFRLDTVDEDLNQGTLKAGKSVRGIAVLASENDVVHKAALIKIS-a........
A0A2A2GVA1_9GAMM/1-65               ............................m---.--------------..-.-------------------------------------------DQPIELT..GdvACYKAFDEKGKEFDGRLVQAEL--LGILKDSPKAGEATFVSDDESVYNAKFVKWS-s........
Q2YR31_BRUA2/1-111                  .........................maqa---.--------------..-.SYAETASTNDLMIIATPKTQSATSSEDKVFFSQTFDIGVANTGATDINLD..K..VCFIALGDKGKTFNADTIDQKLTSGLLKSGESVKGFAAFAGSDKSIYDVRIVKAS-e........
Q11IS2_CHESB/1-120                  .............................MKN.TYAYSILAMAFVLL..S.CSEKAIVEGPIKVTSTRDALEVETDEPGDQ--KAFKVKVENIGVAPVDLT..D..GCFVLVGPDKYKIVANT---PVLDRTILPGQILEGSVVFAGPR-SIFSAREVKFS-ts.......
A0A348HI30_9GAMM/2-125              ....................lkrngilai---.--------MLSMMV..G.SAVAATPADSVMVIASPDGTQTTTQGTTTYFTRLFEVSLTNVGHQPVDLA..H..GCFKAYDRRGTSYSLDIAEEGLLKGMLKPGLHKKGDMGFSSLQPDVYDADVIRFS-td.......
A0A0H5M036_YERIN/1-125              .............................MKK.--AYTVLLSSLVLLsfS.SVAAEDLHNKLIIQAIPSSEGTVTIEGQPNYEKTFKVVVYSKMEQPIELT..GfvGCYKAFDEKGKEFEARTVQADL-LGTLKKG-VKEGEVSFVSDDDSVYNAKFVKWS-s........
Q9I2H0_PSEAE/1-123                  .............................MKN.--AMALTLAGLLAA..P.SLGFAAAPDAVMVFARQGDKGSVSVGDKHFRTQAFKVRLVNAAKSEISLK..N..SCLVAQSAAGQSFRLDTVDEELTADTLKPGASVEGDAIFASEDDAVYGASLVRLSD.........
#=GR Q9I2H0_PSEAE/1-123       SS    .............................XXX.--XXXXXXXXXXXX..X.XXXXXXXXSSEEEEEEEEEEEEEEETTEEEEEEEEEEEEEE-SSS-EE-T..T..-EEEEEETTS-EEEEEEE-GGGG-SEE-TT-EEEEEEEEEESSSGGGGEEEEEEES.........
A0A0F5FHI2_9RHIZ/1-119              ...........................ma---.------ALAAFTTL..A.VATPALANDDIAIIATERANGSMALGDTIAYSKSFDIALTNTVDEPVALE..D..LCLVAVTAEGDTFVLDTVDESLTTGMIEPGAALNGIAVFSSDSITVHTASAVRA--gsd......
A0A0Q4MHG1_9GAMM/1-123              .............................MKS.LFIACTMLFSAACG..A.A--VANAPANLLVYAQAKSEGSMWAGSKSAFTKTFNVSIVNLTDQDIDLA..T..LCLRAYATDTQSFGVDTADELLTKGWLKKGSTVSGVVDFSSGKRDVYQAGMVKV--fh.......
A0A1Y3FXR1_9PROT/1-124              ..........................mkf---.--SAYIIAASLLLG..SvTSAYANAYDSISVYAIEKSHGSIATGSNTAYVKTYNITISNLSDTEADLS..K..ICLKAYSAENKELRLDTVDANLVTGFLKKGQPATGTAIFASHDDIISKPVIVKLSD.........
C4K5R4_HAMD5/1-123                  .............................MRKkIFIASILLAGCCLT..A.A---AKTVDKIIVFSTEKSKGALSIGRQQTYTKTFDIALSNNSQQDIELS..T..SCLKAFDSNGKEFKLDTVDEKLIPNKLKKGELVKGIAMFVSDDASVYGANIVRLVK.........
Q2NPZ4_SODGM/1-56                   .............................---.--------------..-.--------------------------------------------------..-..MCLKAYNGHGKSFKLDTIDDTLTTEKLAPKKTLKGIAVFSSNDESVYDASMVKLSD.........
A0A3D8TTF0_9LIST/31-139             ..........................htq---.------------AI..S.AKTKAIVANGLKIKVKKQEVNQKAEGKKQQQLYTFSIEAENVSATNKGIG..A..IDFVLKLKNGKEIKVDP-SMAAFGDELKKGKSITGTASFAVNSN------------etvsklvyk
A0A366DXJ7_9RHIZ/4-127              .......................iksifl---.--TLYLVAVSGGAY..A.AAPDQNVQP--MVISSVREHSTTVYGDKIEYNITFDVAISNLGKKPLDLS..K..GCFEAVMPDNSTRSLSMIDEELTEGLLKVGDNRKSFVEFSASDNSIYKAVAVKY--qt.......
A0A0N1KIM1_9GAMM/1-126              .............................MKK.TLGTLCLLYLSCSG..Q.ATTLNVEKNSLSVETFSSKNGTLVINGQALYERKLAITVVNRGESKVELTgfS..GCYKAFDKQGKRYVARTTQLDL-LGSIEKNAAKWGEISIVGKDDSVYKAIFVEWS-s........
S3J1Z3_9ENTR/1-123                  .............................MKVlTLVSSLALASFCFS..A.V---AATPENIAVYATHKSTGSMSVGGKSAYTNTFEVMVANVSDKDIDLS..K..VCLKAISPDHKEFKLDTVDEALAKGQLKAGKMAKGIAVFASEDAKVNDALLITL--sg.......
W1JCY7_9GAMM/1-123                  .............................MKVsTLVASVALAGFCFT..A.H---ASALDNVAVYSTEKSNGSISVGGKNAYTKSFEVAVANLSDKDIDLS..K..LCLKAYSPDKKEFSLDTVDEDLNQGTLKAGKSVKGIAVFASENDVVHKAALIKISD.........
A0A0H5LS11_YERIN/1-123              .............................MKVfTIVASLAVAGFSVA..A.N---AVTPSNVAVYATEQSQGSISIGDKNAYTKTFEVALAMLSGEPIDLS..K..LCLKAYSPANEAFKLDTVDEVLSSGHLKVGKIAKGIAVFASDNDNILKAALVKIS-g........
A0A0J9BH82_9GAMM/1-122              ........................mkrnq---.-----LALFFTAIL..S.FSAVAAKTDSIAVIATQQEIGSISTGAKQVFTKRFEVTLANLSDKAINLR..N..LCLTALSPDDKRFKLDTVDDALLSGQLPAQGNHKGLAIFSADDASVYQAVIVKISD.........
D8MW40_ERWBE/1-120                  .............................MKK.ILMLALLMVGVPAY..A.NQLFQPGP----IYATNEDVGSMTDHNKAQYMVSYRISIFNPLDSAATLS..K..GCFVLFNRAGKEIVARGVELNL-QQEFAPGESKTGTVYFFSDNEAIYTLPFVKWIE.........
A0A2X3GN76_9LIST/29-140             ...................tdtkatetak---.--------------..-.AETKDTVVDGLKIKVKKQEVDEKVSDKKKQQLYTFTISGENMSSTNKGLG..A..VDFVLKTKDGKEIEVDP-SMAMFGDEIKPGKTLEGKASFAVDEKQ-----------tatklly..
#=GC SS_cons                        .............................XXX.--XXXXXXXXXXXX..X.XXXXXXXXSSEEEEEEEEEEEEEEETTEEEEEEEEEEEEEE-SSS-EE-T..T..-EEEEEETTS-EEEEEEE-GGGG-SEE-TT-EEEEEEEEEESSSGGGGEEEEEEES.........
#=GC seq_cons                       ...................................h..lhhhuhshh..u.s...AssssslhVhAopcspGohohGspstYs+oFcVslsNlucpsl-Lo..p..hCh+AhsscsKcFplDTlD-sLssGpLKsGpslcGhAlFuSsccsVapAshVKho..........
//
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