GenomeNet

Database: Pfam
Entry: PF17256
LinkDB: PF17256
Original site: PF17256 
#=GF ID   ANAPC16
#=GF AC   PF17256.3
#=GF DE   Anaphase-promoting complex, subunit 16
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD392219
#=GF GA   25.00 25.00;
#=GF TC   25.20 26.50;
#=GF NC   24.90 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Anaphase-promoting_complex
#=GF RN   [1]
#=GF RM   27418942
#=GF RT   Insights into APC/C: from cellular function to diseases and
#=GF RT   therapeutics.
#=GF RA   Zhou Z, He M, Shah AA, Wan Y;
#=GF RL   Cell Div. 2016;11:9.
#=GF RN   [2]
#=GF RM   25490258
#=GF RT   Structure of an APC3-APC16 complex: insights into assembly of
#=GF RT   the anaphase-promoting complex/cyclosome.
#=GF RA   Yamaguchi M, Yu S, Qiao R, Weissmann F, Miller DJ, VanderLinden
#=GF RA   R, Brown NG, Frye JJ, Peters JM, Schulman BA;
#=GF RL   J Mol Biol. 2015;427:1748-1764.
#=GF RN   [3]
#=GF RM   20392738
#=GF RT   APC16 is a conserved subunit of the anaphase-promoting
#=GF RT   complex/cyclosome.
#=GF RA   Kops GJ, van der Voet M, Manak MS, van Osch MH, Naini SM, Brear
#=GF RA   A, McLeod IX, Hentschel DM, Yates JR 3rd, van den Heuvel S, Shah
#=GF RA   JV;
#=GF RL   J Cell Sci. 2010;123:1623-1633.
#=GF DR   INTERPRO; IPR029641;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The Anaphase-promoting complex/cyclosome (APC/C) is a 1.5
#=GF CC   megaDaltons assembly ubiquitin ligase complex comprising 19
#=GF CC   subunits. This multifunctional ubiquitin-protein ligase targets
#=GF CC   different substrates for ubiquitylation and therefore regulates
#=GF CC   a variety of cellular processes such as cell division,
#=GF CC   differentiation, genome stability, energy metabolism, cell
#=GF CC   death, autophagy as well as carcinogenesis [1]. The APC/C
#=GF CC   complex contains two sub-complexes,the Platform and the Arc
#=GF CC   Lamp. The Arc Lamp, which mediates transient association with
#=GF CC   regulators and ubiquitination substrates, contains the small
#=GF CC   subunits APC16, CDC26, APC13, and tetratricopeptide repeat (TPR)
#=GF CC   proteins [2]. APC16 is a conserved subunit of the APC/C. APC16
#=GF CC   was found in association with tandem-affinity-purified mitotic
#=GF CC   checkpoint complex protein complexes. APC16 is a bona fide
#=GF CC   subunit of human APC/C. It is present in APC/C complexes
#=GF CC   throughout the cell cycle. The phenotype of APC16-depleted cells
#=GF CC   copies depletion of other APC/C subunits, and APC16 is important
#=GF CC   for APC/C activity towards mitotic substrates. APC16 sequence
#=GF CC   homologues can be identified in metazoans, but not fungi, by
#=GF CC   four conserved primary sequence stretches [3].
#=GF SQ   225
#=GS A0A2K6DXS4_MACNE/27-106   AC A0A2K6DXS4.1
#=GS A0A1A6GSS6_NEOLE/27-106   AC A0A1A6GSS6.1
#=GS G5C2I3_HETGA/27-106       AC G5C2I3.1
#=GS A0A2K5Z222_MANLE/27-106   AC A0A2K5Z222.1
#=GS A0A384CHG0_URSMA/47-81    AC A0A384CHG0.1
#=GS A0A384CHG0_URSMA/27-48    AC A0A384CHG0.1
#=GS A0A452HDL1_9SAUR/27-104   AC A0A452HDL1.1
#=GS A0A3Q7WF36_URSAR/27-48    AC A0A3Q7WF36.1
#=GS APC16_PONAB/27-106        AC Q5REH8.1
#=GS A0A493SVG7_ANAPP/216-288  AC A0A493SVG7.1
#=GS A0A087XGD9_POEFO/58-137   AC A0A087XGD9.1
#=GS A0A3B3DF54_ORYME/54-133   AC A0A3B3DF54.1
#=GS A0A2K6M9Y8_RHIBE/47-81    AC A0A2K6M9Y8.1
#=GS A0A099ZKE7_TINGU/25-70    AC A0A099ZKE7.1
#=GS A0A093GSG6_STRCA/27-106   AC A0A093GSG6.1
#=GS A0A2I2U7L2_FELCA/47-81    AC A0A2I2U7L2.1
#=GS A0A093GGK7_DRYPU/27-106   AC A0A093GGK7.1
#=GS M3XIP8_LATCH/27-106       AC M3XIP8.1
#=GS A0A3Q7WF36_URSAR/47-81    AC A0A3Q7WF36.1
#=GS A0A3B4DMM0_PYGNA/27-77    AC A0A3B4DMM0.1
#=GS A0A2K6TBP6_SAIBB/27-106   AC A0A2K6TBP6.1
#=GS A0A2U9CQ01_SCOMX/27-106   AC A0A2U9CQ01.1
#=GS A0A093Q4N5_9PASS/27-104   AC A0A093Q4N5.1
#=GS A0A2U3V4Z7_TURTR/27-106   AC A0A2U3V4Z7.1
#=GS A0A2Y9EM97_PHYMC/92-171   AC A0A2Y9EM97.1
#=GS A0A2U3ZTP9_ODORO/27-48    AC A0A2U3ZTP9.1
#=GS H2LZC6_ORYLA/47-81        AC H2LZC6.2
#=GS A0A287CUY2_ICTTR/1-28     AC A0A287CUY2.1
#=GS A0A2U3XIE3_LEPWE/47-81    AC A0A2U3XIE3.1
#=GS A0A2K6TBP4_SAIBB/47-81    AC A0A2K6TBP4.1
#=GS A0A1U7S9K6_ALLSI/51-130   AC A0A1U7S9K6.1
#=GS M7BAQ6_CHEMY/27-106       AC M7BAQ6.1
#=GS F6W110_HORSE/38-117       AC F6W110.2
#=GS A0A3Q7SGD8_VULVU/27-48    AC A0A3Q7SGD8.1
#=GS A0A2K5LGG0_CERAT/27-106   AC A0A2K5LGG0.1
#=GS A0A226N8A7_CALSU/51-130   AC A0A226N8A7.1
#=GS G3NCP7_GASAC/27-106       AC G3NCP7.1
#=GS D3ZDN9_RAT/46-125         AC D3ZDN9.2
#=GS A0A2K5Z227_MANLE/27-48    AC A0A2K5Z227.1
#=GS E1BVD8_CHICK/51-130       AC E1BVD8.2
#=GS A0A2I3LKW3_PAPAN/47-81    AC A0A2I3LKW3.1
#=GS F6TCS8_MACMU/27-106       AC F6TCS8.1
#=GS A0A3B5KBG3_TAKRU/47-81    AC A0A3B5KBG3.1
#=GS A0A2K5X5W4_MACFA/27-106   AC A0A2K5X5W4.1
#=GS A0A0D9R872_CHLSB/27-106   AC A0A0D9R872.1
#=GS A0A1S3HZW9_LINUN/7-85     AC A0A1S3HZW9.1
#=GS A0A2K6M9Y8_RHIBE/27-48    AC A0A2K6M9Y8.1
#=GS U3CQN2_CALJA/47-81        AC U3CQN2.1
#=GS A0A226P512_COLVI/51-130   AC A0A226P512.1
#=GS A0A3P9A1C9_ESOLU/27-106   AC A0A3P9A1C9.1
#=GS A0A2U9CMS1_SCOMX/38-117   AC A0A2U9CMS1.1
#=GS A0A3P8TTE1_AMPPE/27-87    AC A0A3P8TTE1.1
#=GS A0A0Q3PIR3_AMAAE/51-130   AC A0A0Q3PIR3.1
#=GS A0A2K5LGG4_CERAT/47-81    AC A0A2K5LGG4.1
#=GS A0A2K6EW43_PROCO/47-81    AC A0A2K6EW43.1
#=GS U3KDX8_FICAL/27-106       AC U3KDX8.1
#=GS A0A452QZ62_URSAM/42-121   AC A0A452QZ62.1
#=GS A0A3B4V7P2_SERDU/27-106   AC A0A3B4V7P2.1
#=GS A0A3Q1GKN0_9TELE/27-48    AC A0A3Q1GKN0.1
#=GS H2R7P6_PANTR/27-106       AC H2R7P6.1
#=GS A0A3Q3ATS5_KRYMA/27-106   AC A0A3Q3ATS5.1
#=GS A0A2R9BRU7_PANPA/27-48    AC A0A2R9BRU7.1
#=GS A0A3B3V2L1_9TELE/27-106   AC A0A3B3V2L1.1
#=GS A0A2U3ZTP9_ODORO/47-81    AC A0A2U3ZTP9.1
#=GS M3XY98_MUSPF/27-106       AC M3XY98.1
#=GS A0A091W7B8_OPIHO/27-106   AC A0A091W7B8.1
#=GS A0A452QZF8_URSAM/27-106   AC A0A452QZF8.1
#=GS A0A286XSZ5_CAVPO/35-114   AC A0A286XSZ5.1
#=GS A0A2U9CPS2_SCOMX/65-144   AC A0A2U9CPS2.1
#=GS A0A3B4YT94_SERLL/27-106   AC A0A3B4YT94.1
#=GS A0A091ERH0_CORBR/27-106   AC A0A091ERH0.1
#=GS A0A2K6M9Z0_RHIBE/27-106   AC A0A2K6M9Z0.1
#=GS I3KGM1_ORENI/27-106       AC I3KGM1.1
#=GS A0A091I5T5_CALAN/27-106   AC A0A091I5T5.1
#=GS A0A2K6QII2_RHIRO/47-81    AC A0A2K6QII2.1
#=GS B5G162_TAEGU/27-106       AC B5G162.1
#=GS A0A2K6QIG4_RHIRO/27-106   AC A0A2K6QIG4.1
#=GS G1S323_NOMLE/27-48        AC G1S323.2
#=GS A0A1D5R1P1_MACMU/27-48    AC A0A1D5R1P1.1
#=GS A0A4D9EXD0_9SAUR/27-106   AC A0A4D9EXD0.1
#=GS A0A1L8FF05_XENLA/59-138   AC A0A1L8FF05.1
#=GS A0A3Q3ML58_9TELE/27-106   AC A0A3Q3ML58.1
#=GS A0A2Y9G2U7_TRIMA/27-106   AC A0A2Y9G2U7.1
#=GS A0A2K5X5X3_MACFA/47-81    AC A0A2K5X5X3.1
#=GS G3W0E5_SARHA/27-106       AC G3W0E5.1
#=GS A0A3B1JLP4_ASTMX/27-48    AC A0A3B1JLP4.1
#=GS A0A498LMY8_LABRO/27-48    AC A0A498LMY8.1
#=GS A0A2I3M4N1_PAPAN/27-106   AC A0A2I3M4N1.1
#=GS A0A3Q1GKN0_9TELE/47-81    AC A0A3Q1GKN0.1
#=GS A0A3B5AIG5_9TELE/48-127   AC A0A3B5AIG5.1
#=GS A0A218UDK8_9PASE/27-106   AC A0A218UDK8.1
#=GS A0A2I2U7L2_FELCA/27-48    AC A0A2I2U7L2.1
#=GS A0A3B3Y2G4_9TELE/27-106   AC A0A3B3Y2G4.1
#=GS A0A3Q4MS37_NEOBR/27-106   AC A0A3Q4MS37.1
#=GS A0A2I3S1N7_PANTR/27-48    AC A0A2I3S1N7.1
#=GS A0A2K5X5X3_MACFA/27-48    AC A0A2K5X5X3.1
#=GS A0A452HDI3_9SAUR/138-217  AC A0A452HDI3.1
#=GS A0A2K5S282_CEBCA/84-148   AC A0A2K5S282.1
#=GS A0A1D5R1P1_MACMU/47-81    AC A0A1D5R1P1.1
#=GS G3I1Z2_CRIGR/27-106       AC G3I1Z2.1
#=GS Q4RE77_TETNG/27-106       AC Q4RE77.1
#=GS A0A3P8NRE8_ASTCA/27-48    AC A0A3P8NRE8.1
#=GS A0A3B5KBG3_TAKRU/27-48    AC A0A3B5KBG3.1
#=GS A0A2K6EW43_PROCO/27-48    AC A0A2K6EW43.1
#=GS A0A2K5HN44_COLAP/27-48    AC A0A2K5HN44.1
#=GS A0A3Q7SGD8_VULVU/47-81    AC A0A3Q7SGD8.1
#=GS A0A2R9BSH4_PANPA/27-106   AC A0A2R9BSH4.1
#=GS A0A3B4H1U3_9CICH/27-106   AC A0A3B4H1U3.1
#=GS A0A3P8TS68_AMPPE/27-106   AC A0A3P8TS68.1
#=GS A0A087WUN5_HUMAN/27-48    AC A0A087WUN5.1
#=GS W5PB31_SHEEP/27-106       AC W5PB31.1
#=GS A0A3P8NRE8_ASTCA/47-81    AC A0A3P8NRE8.1
#=GS G1TCB4_RABIT/27-106       AC G1TCB4.1
#=GS I3LX58_ICTTR/39-118       AC I3LX58.2
#=GS A0A3B3ZJA0_9GOBI/27-106   AC A0A3B3ZJA0.1
#=GS A0A3P9MZF3_POERE/27-106   AC A0A3P9MZF3.1
#=GS A0A498LMY8_LABRO/47-81    AC A0A498LMY8.1
#=GS A0A3Q1AXH7_AMPOC/27-106   AC A0A3Q1AXH7.1
#=GS A0A2K5HN44_COLAP/47-81    AC A0A2K5HN44.1
#=GS A0A3B4BUS1_PYGNA/27-106   AC A0A3B4BUS1.1
#=GS H2LZC6_ORYLA/27-48        AC H2LZC6.2
#=GS A0A0A0A576_CHAVO/27-106   AC A0A0A0A576.1
#=GS A0A2U3XIA1_LEPWE/27-106   AC A0A2U3XIA1.1
#=GS A0A402EIQ2_9SAUR/118-197  AC A0A402EIQ2.1
#=GS A0A2B4SXC2_STYPI/10-89    AC A0A2B4SXC2.1
#=GS F6S1D6_MONDO/27-105       AC F6S1D6.2
#=GS APC16_XENTR/27-107        AC Q6DJQ9.1
#=GS A0A2Y9PU89_DELLE/26-105   AC A0A2Y9PU89.1
#=GS A0A1L8FJU3_XENLA/59-138   AC A0A1L8FJU3.1
#=GS R0JCY2_ANAPL/27-106       AC R0JCY2.1
#=GS F6X634_CALJA/27-106       AC F6X634.1
#=GS A0A401QFG8_SCYTO/44-123   AC A0A401QFG8.1
#=GS A0A1V4KK04_PATFA/27-106   AC A0A1V4KK04.1
#=GS A0A060Y8J4_ONCMY/1-62     AC A0A060Y8J4.1
#=GS A0A3L8S5W6_CHLGU/27-106   AC A0A3L8S5W6.1
#=GS A0A287DA35_ICTTR/27-106   AC A0A287DA35.1
#=GS A0A3B3S0G3_9TELE/27-106   AC A0A3B3S0G3.1
#=GS A0A3Q7XCF4_URSAR/27-106   AC A0A3Q7XCF4.1
#=GS APC16_MOUSE/27-106        AC Q9CPV2.1
#=GS F6ZFL8_ORNAN/27-106       AC F6ZFL8.1
#=GS A0A401T330_CHIPU/22-101   AC A0A401T330.1
#=GS A0A087WUN5_HUMAN/47-81    AC A0A087WUN5.1
#=GS A0A493T3V5_ANAPP/216-290  AC A0A493T3V5.1
#=GS A0A452EUZ6_CAPHI/27-106   AC A0A452EUZ6.1
#=GS A0A2K6TBP4_SAIBB/27-48    AC A0A2K6TBP4.1
#=GS W5MDA4_LEPOC/35-114       AC W5MDA4.1
#=GS A0A3Q3WKK0_MOLML/27-106   AC A0A3Q3WKK0.1
#=GS A0A383YY24_BALAS/27-106   AC A0A383YY24.1
#=GS A0A2K5C8C3_AOTNA/27-106   AC A0A2K5C8C3.1
#=GS A0A493T1L1_ANAPP/216-288  AC A0A493T1L1.1
#=GS A0A2K6QII2_RHIRO/27-48    AC A0A2K6QII2.1
#=GS A0A2U9CMQ0_SCOMX/32-111   AC A0A2U9CMQ0.1
#=GS A0A2I3FYA7_NOMLE/27-106   AC A0A2I3FYA7.1
#=GS A0A384CH90_URSMA/27-106   AC A0A384CH90.1
#=GS Q561X1_DANRE/27-106       AC Q561X1.1
#=GS A0A493TR21_ANAPP/41-103   AC A0A493TR21.1
#=GS A0A1U7UEK6_TARSY/27-106   AC A0A1U7UEK6.1
#=GS A0A3Q2W5U7_HAPBU/27-106   AC A0A3Q2W5U7.1
#=GS A0A3Q1H5D4_ANATE/27-106   AC A0A3Q1H5D4.1
#=GS A0A087XGE4_POEFO/27-106   AC A0A087XGE4.1
#=GS A0A3Q0H3S1_ALLSI/51-130   AC A0A3Q0H3S1.1
#=GS A0A091E2P1_FUKDA/1-59     AC A0A091E2P1.1
#=GS H0WXZ2_OTOGA/27-106       AC H0WXZ2.1
#=GS A0A2K5C899_AOTNA/47-81    AC A0A2K5C899.1
#=GS A0A2I4B3X0_9TELE/27-106   AC A0A2I4B3X0.1
#=GS A0A3Q2FI18_CYPVA/27-106   AC A0A3Q2FI18.1
#=GS A0A2K5HN64_COLAP/27-106   AC A0A2K5HN64.1
#=GS A0A1S3QPM5_SALSA/27-106   AC A0A1S3QPM5.1
#=GS A0A287BSR1_PIG/27-106     AC A0A287BSR1.1
#=GS A0A091V3Y4_NIPNI/27-106   AC A0A091V3Y4.1
#=GS A0A286Y0U6_CAVPO/27-48    AC A0A286Y0U6.1
#=GS L5KCY7_PTEAL/27-106       AC L5KCY7.1
#=GS A0A087QMW0_APTFO/27-106   AC A0A087QMW0.1
#=GS A0A2K5LGG4_CERAT/27-48    AC A0A2K5LGG4.1
#=GS A0A452HDL0_9SAUR/138-215  AC A0A452HDL0.1
#=GS G1N1E6_MELGA/27-106       AC G1N1E6.1
#=GS G1S323_NOMLE/47-81        AC G1S323.2
#=GS K7GI92_PELSI/27-107       AC K7GI92.1
#=GS E2RKJ5_CANLF/27-106       AC E2RKJ5.1
#=GS A0A151NZV1_ALLMI/27-106   AC A0A151NZV1.1
#=GS H0XY95_OTOGA/27-106       AC H0XY95.1
#=GS A0A3P8WGM5_CYNSE/27-106   AC A0A3P8WGM5.1
#=GS A0A3P9AUJ3_9CICH/27-106   AC A0A3P9AUJ3.1
#=GS A0A2D0SB50_ICTPU/28-107   AC A0A2D0SB50.1
#=GS G1P4W6_MYOLU/27-106       AC G1P4W6.1
#=GS A0A2Y9JBR2_ENHLU/27-106   AC A0A2Y9JBR2.1
#=GS M4AKL2_XIPMA/27-106       AC M4AKL2.1
#=GS A0A2Y9T3K2_PHYMC/27-106   AC A0A2Y9T3K2.1
#=GS A0A2I3S1N7_PANTR/47-81    AC A0A2I3S1N7.1
#=GS A0A2K5Z227_MANLE/47-81    AC A0A2K5Z227.1
#=GS D2HZB3_AILME/27-106       AC D2HZB3.1
#=GS A0A2I3LKW3_PAPAN/27-48    AC A0A2I3LKW3.1
#=GS A0A091K2I6_EGRGA/27-106   AC A0A091K2I6.1
#=GS S4R2B6_MOUSE/46-125       AC S4R2B6.1
#=GS A0A1S3ARX3_ERIEU/27-106   AC A0A1S3ARX3.1
#=GS APC16_BOVIN/27-106        AC Q58DR0.1
#=GS A0A2U3WUQ9_ODORO/27-106   AC A0A2U3WUQ9.1
#=GS G1K970_ANOCA/27-107       AC G1K970.1
#=GS A0A3B1JLP4_ASTMX/47-81    AC A0A3B1JLP4.1
#=GS A0A3Q3FR21_9LABR/27-106   AC A0A3Q3FR21.1
#=GS A0A1S3FYX2_DIPOR/27-79    AC A0A1S3FYX2.1
#=GS A0A2U3XIE3_LEPWE/27-48    AC A0A2U3XIE3.1
#=GS A0A091GEL0_9AVES/27-106   AC A0A091GEL0.1
#=GS A0A3Q0CRG2_MESAU/27-106   AC A0A3Q0CRG2.1
#=GS A0A493TX67_ANAPP/216-291  AC A0A493TX67.1
#=GS A0A2K6DXT1_MACNE/47-81    AC A0A2K6DXT1.1
#=GS A0A2R9BRU7_PANPA/47-81    AC A0A2R9BRU7.1
#=GS U3IJP2_ANAPP/216-287      AC U3IJP2.2
#=GS A0A340WZH6_LIPVE/27-106   AC A0A340WZH6.1
#=GS A0A2K6EVZ7_PROCO/27-106   AC A0A2K6EVZ7.1
#=GS A0A2K6DXT1_MACNE/27-48    AC A0A2K6DXT1.1
#=GS A0A286Y0U6_CAVPO/47-81    AC A0A286Y0U6.1
#=GS A0A3Q0TC00_AMPCI/27-48    AC A0A3Q0TC00.1
#=GS S4R1V1_MOUSE/1-28         AC S4R1V1.1
#=GS A0A2I2UKW1_FELCA/27-106   AC A0A2I2UKW1.1
#=GS A0A3Q0TC00_AMPCI/47-81    AC A0A3Q0TC00.1
#=GS H3BDB4_LATCH/27-115       AC H3BDB4.1
#=GS A0A3Q7SGD0_VULVU/27-106   AC A0A3Q7SGD0.1
#=GS U3CQN2_CALJA/27-48        AC U3CQN2.1
#=GS A0A2K5C899_AOTNA/27-48    AC A0A2K5C899.1
#=GS A0A091E452_FUKDA/27-106   AC A0A091E452.1
#=GS G3QX71_GORGO/27-87        AC G3QX71.2
#=GS A0A2Y9EM97_PHYMC/27-73    AC A0A2Y9EM97.1
#=GS G3TNL9_LOXAF/27-106       AC G3TNL9.1
#=GS APC16_HUMAN/27-106        AC Q96DE5.1
#=GS APC16_HUMAN/27-106        DR PDB; 4RG6 S; 74-106;
#=GS APC16_HUMAN/27-106        DR PDB; 5G05 E; 52-106;
#=GS APC16_HUMAN/27-106        DR PDB; 4RG9 S; 74-106;
#=GS APC16_HUMAN/27-106        DR PDB; 5G04 E; 52-106;
#=GS APC16_HUMAN/27-106        DR PDB; 6Q6H H; 51-106;
#=GS APC16_HUMAN/27-106        DR PDB; 5LCW E; 52-106;
#=GS APC16_HUMAN/27-106        DR PDB; 5A31 E; 52-106;
#=GS APC16_HUMAN/27-106        DR PDB; 4UI9 E; 52-106;
#=GS APC16_HUMAN/27-106        DR PDB; 6Q6G H; 51-106;
A0A2K6DXS4_MACNE/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A1A6GSS6_NEOLE/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
G5C2I3_HETGA/27-106                  ......DLAPPRKALFNYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K5Z222_MANLE/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A384CHG0_URSMA/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A384CHG0_URSMA/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A452HDL1_9SAUR/27-104              ......ELAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRTKA--------nahwls.................
A0A3Q7WF36_URSAR/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
APC16_PONAB/27-106                   ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A493SVG7_ANAPP/216-288             ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRA----------rlg....................
A0A087XGD9_POEFO/58-137              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKQ.DQQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3B3DF54_ORYME/54-133              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2K6M9Y8_RHIBE/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A099ZKE7_TINGU/25-70               ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.----------------------------------.......................
A0A093GSG6_STRCA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWKKKPIEQLLGFT.......................
A0A2I2U7L2_FELCA/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A093GGK7_DRYPU/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
M3XIP8_LATCH/27-106                  ......DLVPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVACTLKQVKQ.CQQVARMDKLSSLVEELEADEWRYKPIEQLLGF-a......................
A0A3Q7WF36_URSAR/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3B4DMM0_PYGNA/27-77               ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.G---------------------------------frss...................
A0A2K6TBP6_SAIBB/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2U9CQ01_SCOMX/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A093Q4N5_9PASS/27-104              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSFQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRDKPKKEPLG--.......................
A0A2U3V4Z7_TURTR/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2Y9EM97_PHYMC/92-171              ......DLAPPRKDLFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2U3ZTP9_ODORO/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
H2LZC6_ORYLA/47-81                   .....e---------------------.........-------------------------.DQQVSRMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A287CUY2_ICTTR/1-28                ......---------------------.........-------------------------.------MEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2U3XIE3_LEPWE/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K6TBP4_SAIBB/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A1U7S9K6_ALLSI/51-130              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
M7BAQ6_CHEMY/27-106                  ......ELAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
F6W110_HORSE/38-117                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3Q7SGD8_VULVU/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A2K5LGG0_CERAT/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A226N8A7_CALSU/51-130              ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
G3NCP7_GASAC/27-106                  ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
D3ZDN9_RAT/46-125                    ......DLAPPRKALFTYPKGAGEILE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K5Z227_MANLE/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
E1BVD8_CHICK/51-130                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2I3LKW3_PAPAN/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
F6TCS8_MACMU/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3B5KBG3_TAKRU/47-81               .....e---------------------.........-------------------------.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2K5X5W4_MACFA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A0D9R872_CHLSB/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A1S3HZW9_LINUN/7-85                ..qdni-----RKALFRSPAVDQAQSS.........DITDTLMSKLQIEQDVETSVRILHK.EQHEQTLKQLRQKLKDLTKDDWRYQPVNQLIGL-e......................
A0A2K6M9Y8_RHIBE/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
U3CQN2_CALJA/47-81                   .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A226P512_COLVI/51-130              ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A3P9A1C9_ESOLU/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2U9CMS1_SCOMX/38-117              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3P8TTE1_AMPPE/27-87               ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.GKSVTAYAK-------------------------cvcfgg.................
A0A0Q3PIR3_AMAAE/51-130              ......DLTPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2K5LGG4_CERAT/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K6EW43_PROCO/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
U3KDX8_FICAL/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSFQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A452QZ62_URSAM/42-121              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3B4V7P2_SERDU/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3Q1GKN0_9TELE/27-48               ......ELIPPRKVLYTYPKGAGEMME.........D------------------------.----------------------------------.......................
H2R7P6_PANTR/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3Q3ATS5_KRYMA/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKQ.DHQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2R9BRU7_PANPA/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A3B3V2L1_9TELE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKQ.DQQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2U3ZTP9_ODORO/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
M3XY98_MUSPF/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A091W7B8_OPIHO/27-106              ......DLTPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A452QZF8_URSAM/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A286XSZ5_CAVPO/35-114              ......DLAPPRKALFNYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2U9CPS2_SCOMX/65-144              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3B4YT94_SERLL/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A091ERH0_CORBR/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSFQVASTLKQVKH.DQQVTRMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2K6M9Z0_RHIBE/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
I3KGM1_ORENI/27-106                  ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A091I5T5_CALAN/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVTRMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2K6QII2_RHIRO/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
B5G162_TAEGU/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSFQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2K6QIG4_RHIRO/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
G1S323_NOMLE/27-48                   ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A1D5R1P1_MACMU/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A4D9EXD0_9SAUR/27-106              ......ELAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A1L8FF05_XENLA/59-138              ......DLAPPRKALFTCPKAAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVSRMEKLAGLVEELEADEWRYTPIEQLLGFT.......................
A0A3Q3ML58_9TELE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2Y9G2U7_TRIMA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K5X5X3_MACFA/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
G3W0E5_SARHA/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A3B1JLP4_ASTMX/27-48               ......ELIPPRKVLYTYPKGAGEMME.........D------------------------.----------------------------------.......................
A0A498LMY8_LABRO/27-48               ......ELIPPRKVLYTYPKGAGEMME.........D------------------------.----------------------------------.......................
A0A2I3M4N1_PAPAN/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3Q1GKN0_9TELE/47-81               .....e---------------------.........-------------------------.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3B5AIG5_9TELE/48-127              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A218UDK8_9PASE/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSFQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2I2U7L2_FELCA/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A3B3Y2G4_9TELE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKQ.DQQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3Q4MS37_NEOBR/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2I3S1N7_PANTR/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A2K5X5X3_MACFA/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A452HDI3_9SAUR/138-217             ......ELAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2K5S282_CEBCA/84-148              flgtql---------------------.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A1D5R1P1_MACMU/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
G3I1Z2_CRIGR/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
Q4RE77_TETNG/27-106                  ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3P8NRE8_ASTCA/27-48               ......ELIPPRKVLYTYPKGAGEMME.........D------------------------.----------------------------------.......................
A0A3B5KBG3_TAKRU/27-48               ......ELIPPRKVLYTYPKGAGEMME.........D------------------------.----------------------------------.......................
A0A2K6EW43_PROCO/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A2K5HN44_COLAP/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A3Q7SGD8_VULVU/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2R9BSH4_PANPA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3B4H1U3_9CICH/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3P8TS68_AMPPE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A087WUN5_HUMAN/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
W5PB31_SHEEP/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3P8NRE8_ASTCA/47-81               .....e---------------------.........-------------------------.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
G1TCB4_RABIT/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
I3LX58_ICTTR/39-118                  ......DLAPPRKTLFTYPKGAGEVLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3B3ZJA0_9GOBI/27-106              ......DLTPPRKVLFTYPKGSGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3P9MZF3_POERE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKQ.DQQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A498LMY8_LABRO/47-81               .....e---------------------.........-------------------------.DQQVSRMERLAGLVEQLEADEWKYKPIEQLLGFT.......................
A0A3Q1AXH7_AMPOC/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2K5HN44_COLAP/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3B4BUS1_PYGNA/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWKYKPIEQLLGFT.......................
H2LZC6_ORYLA/27-48                   ......ELIPPRKVLYTYPKGAGEMME.........D------------------------.----------------------------------.......................
A0A0A0A576_CHAVO/27-106              ......DMASPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2U3XIA1_LEPWE/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A402EIQ2_9SAUR/118-197             ......DLATPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2B4SXC2_STYPI/10-89               .....q-LKETRKALFRTPDQDDNSKA........pEALEALLNRIQVDIEVDSNLQSLRK.EIHEQALTKLRQELTQIGQDEWMYKPIDQIIGF-.......................
F6S1D6_MONDO/27-105                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRL----------lmspyfqlp..............
APC16_XENTR/27-107                   ......DLAPPRKALFTCPKAAGEMLE........aDGSERFLCESVFSYQVASTLKQVKH.DQQVSRMEKLAGLVEELEADEWRYTPIEQLLGFT.......................
A0A2Y9PU89_DELLE/26-105              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A1L8FJU3_XENLA/59-138              ......DLAPPRKALFTCPKAAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVSRMEKLAGLVEELEADEWRYTPIEQLLGFT.......................
R0JCY2_ANAPL/27-106                  ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
F6X634_CALJA/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A401QFG8_SCYTO/44-123              ......ELTPPRKVLFTSPKGASELLE.........DVTERFLCEAVFSYQVAHTLRQVKR.EQQCSRMEKLASLVEELEADEWCHKPIEQLLGFT.......................
A0A1V4KK04_PATFA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A060Y8J4_ONCMY/1-62                ...mns---------------------.........YGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3L8S5W6_CHLGU/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSFQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A287DA35_ICTTR/27-106              ......DLAPPRKTLFTYPKGAGEVLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3B3S0G3_9TELE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3Q7XCF4_URSAR/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
APC16_MOUSE/27-106                   ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
F6ZFL8_ORNAN/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A401T330_CHIPU/22-101              ......ELTPPRKVLFTSPKGAGELLE.........DATERFLCEAVFSYQVAHTLRQVKR.EQQCSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A087WUN5_HUMAN/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A493T3V5_ANAPP/216-290             ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRV----------lqeps..................
A0A452EUZ6_CAPHI/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K6TBP4_SAIBB/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
W5MDA4_LEPOC/35-114                  ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLSSLVEDLEADEWRYKPIEQLLGFT.......................
A0A3Q3WKK0_MOLML/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A383YY24_BALAS/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2K5C8C3_AOTNA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A493T1L1_ANAPP/216-288             ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWS-----------sats...................
A0A2K6QII2_RHIRO/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A2U9CMQ0_SCOMX/32-111              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2I3FYA7_NOMLE/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A384CH90_URSMA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
Q561X1_DANRE/27-106                  ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMERLAGLVEQLEADEWKYKPIEQLLGFT.......................
A0A493TR21_ANAPP/41-103              ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.EPDSAD----------------------------qaslpdldlll............
A0A1U7UEK6_TARSY/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3Q2W5U7_HAPBU/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3Q1H5D4_ANATE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A087XGE4_POEFO/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKQ.DQQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3Q0H3S1_ALLSI/51-130              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A091E2P1_FUKDA/1-59                ......---------------------.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
H0WXZ2_OTOGA/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K5C899_AOTNA/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2I4B3X0_9TELE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........GNLESPLCLHVFSYQVASTLKQVKQ.DQQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3Q2FI18_CYPVA/27-106              ......DLIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKQ.DQQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2K5HN64_COLAP/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A1S3QPM5_SALSA/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A287BSR1_PIG/27-106                ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLASLVEELEADEWRFKPIEQLLGFT.......................
A0A091V3Y4_NIPNI/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A286Y0U6_CAVPO/27-48               ......DLAPPRKALFNYPKGAGEMLE.........D------------------------.----------------------------------.......................
L5KCY7_PTEAL/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A087QMW0_APTFO/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A2K5LGG4_CERAT/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A452HDL0_9SAUR/138-215             ......ELAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRTKA--------nahwls.................
G1N1E6_MELGA/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
G1S323_NOMLE/47-81                   .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
K7GI92_PELSI/27-107                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKHvDQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
E2RKJ5_CANLF/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A151NZV1_ALLMI/27-106              ......DLAPPRKALFTYPKAAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
H0XY95_OTOGA/27-106                  ......DLAPPGKALFTDPKGAGEMLE.........EGSEGFLCESVFSYQVAATLKQVKH.DQQVARMEKLAGLVEELEANQWRFKPIQQLLGFT.......................
A0A3P8WGM5_CYNSE/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A3P9AUJ3_9CICH/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2D0SB50_ICTPU/28-107              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWKYKPIEQLLGFT.......................
G1P4W6_MYOLU/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2Y9JBR2_ENHLU/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
M4AKL2_XIPMA/27-106                  ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKQ.DQQASRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A2Y9T3K2_PHYMC/27-106              ......DLAPPRKDLFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADXWQFKPIQQLLGFT.......................
A0A2I3S1N7_PANTR/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K5Z227_MANLE/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
D2HZB3_AILME/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2I3LKW3_PAPAN/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A091K2I6_EGRGA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
S4R2B6_MOUSE/46-125                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A1S3ARX3_ERIEU/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
APC16_BOVIN/27-106                   ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2U3WUQ9_ODORO/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
G1K970_ANOCA/27-107                  ......DLATPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKHaDQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A3B1JLP4_ASTMX/47-81               .....e---------------------.........-------------------------.DQQVSRMEKLASLVEELEADEWKYKPIEQLLGFT.......................
A0A3Q3FR21_9LABR/27-106              ......ELIPPRKVLYTYPKGAGEMME.........DGSDRFLCESVFSYQVASTLKQVKH.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
A0A1S3FYX2_DIPOR/27-79               ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.GK--------------------------------hkvws..................
A0A2U3XIE3_LEPWE/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A091GEL0_9AVES/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRYKPIEQLLGFT.......................
A0A3Q0CRG2_MESAU/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A493TX67_ANAPP/216-291             ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.EPDSADQ---------------------------aslpdldlllhdpedevlcaqll
A0A2K6DXT1_MACNE/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2R9BRU7_PANPA/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
U3IJP2_ANAPP/216-287                 ......DLAPPRKALFSYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWS-----------leg....................
A0A340WZH6_LIPVE/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K6EVZ7_PROCO/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2K6DXT1_MACNE/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A286Y0U6_CAVPO/47-81               .....e---------------------.........-------------------------.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3Q0TC00_AMPCI/27-48               ......ELIPPRKVLYTYPKGAGEMME.........D------------------------.----------------------------------.......................
S4R1V1_MOUSE/1-28                    ......---------------------.........-------------------------.------MEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A2I2UKW1_FELCA/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
A0A3Q0TC00_AMPCI/47-81               .....e---------------------.........-------------------------.DQQVSRMEKLASLVEELEADEWRYKPIEQLLGFT.......................
H3BDB4_LATCH/27-115                  ......DLVPPRKALFTYPKGAGEMLEglqrcawptDGSERFLCESVFSYQVACTLKQVKQ.CQQVARMDKLSSLVEELEADEWRYKPIEQLLGF-a......................
A0A3Q7SGD0_VULVU/27-106              ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
U3CQN2_CALJA/27-48                   ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A2K5C899_AOTNA/27-48               ......DLAPPRKALFTYPKGAGEMLE.........D------------------------.----------------------------------.......................
A0A091E452_FUKDA/27-106              ......DLAPPRKALFNYPKRAGEMLK.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
G3QX71_GORGO/27-87                   ......ELAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.GKHM------------------------------svayltvrinl............
A0A2Y9EM97_PHYMC/27-73               ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLN----.----------------------------------sssss..................
G3TNL9_LOXAF/27-106                  ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
APC16_HUMAN/27-106                   ......DLAPPRKALFTYPKGAGEMLE.........DGSERFLCESVFSYQVASTLKQVKH.DQQVARMEKLAGLVEELEADEWRFKPIEQLLGFT.......................
#=GR APC16_HUMAN/27-106        SS    ......XXXXXXXXXXXXXXXXXXXXX.........XXX-CHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHHHTGGGS--HHHHTTS-.......................
#=GC SS_cons                         ......XXXXXXXXXXXXXXXXXXXXX.........XXX-CHHHHHHHHHHHHHHHHHHHH.HHHHHHHHHHHHHHHHHHHTGGGS--HHHHTTS-.......................
#=GC seq_cons                        ......-LsPPRKALFTYPKGAGEMLE.........DGS-RFLCESVFSYQVASTLKQVKH.DQQVuRMEKLAGLVEELEADEWRaKPIEQLLGFT.......................
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