#=GF ID   DUF5373
#=GF AC   PF17343.4
#=GF DE   Family of unknown function (DUF5373)
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD035609
#=GF GA   28.70 28.70;
#=GF TC   35.20 32.00;
#=GF NC   27.10 26.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR035321;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of unknown function is found in Caenorhabditis.
#=GF CC   Members of this family are predicted to contain 4 trans-membrane
#=GF CC   regions.
#=GF SQ   26
#=GS YLH9_CAEEL/3-177        AC P34363.1
#=GS YLH0_CAEEL/1-179        AC P34364.2
#=GS E3LSC5_CAERE/9-135      AC E3LSC5.1
#=GS A0A2G5UHA3_9PELO/4-165  AC A0A2G5UHA3.1
#=GS A0A2H2J2B9_CAEJA/1-50   AC A0A2H2J2B9.1
#=GS A0A2H2I2L9_CAEJA/1-105  AC A0A2H2I2L9.1
#=GS B6IHL7_CAEBR/1-177      AC B6IHL7.1
#=GS G0MK62_CAEBE/4-179      AC G0MK62.1
#=GS G0MK60_CAEBE/1-154      AC G0MK60.1
#=GS G0MK59_CAEBE/1-184      AC G0MK59.1
#=GS A8XA93_CAEBR/1-186      AC A8XA93.1
#=GS E3LSC9_CAERE/1-175      AC E3LSC9.1
#=GS A0A2G5UIA9_9PELO/1-186  AC A0A2G5UIA9.1
#=GS A0A2G5UHD3_9PELO/3-156  AC A0A2G5UHD3.1
#=GS A0A2G5UHL6_9PELO/5-174  AC A0A2G5UHL6.1
#=GS A0A2G5UHY7_9PELO/5-183  AC A0A2G5UHY7.1
#=GS E3LSC4_CAERE/1-179      AC E3LSC4.1
#=GS A0A2G5UHB9_9PELO/1-177  AC A0A2G5UHB9.1
#=GS A8XA96_CAEBR/1-151      AC A8XA96.1
#=GS G0MK63_CAEBE/1-184      AC G0MK63.1
#=GS YLH6_CAEEL/11-169       AC P34360.1
#=GS E3LSC6_CAERE/5-188      AC E3LSC6.1
#=GS A0A2G5UHB1_9PELO/1-151  AC A0A2G5UHB1.1
#=GS A0A2G5UH99_9PELO/1-165  AC A0A2G5UH99.1
#=GS YLH7_CAEEL/1-153        AC P34361.1
#=GS E3LSC8_CAERE/1-104      AC E3LSC8.1
YLH9_CAEEL/3-177                   ..........nnysidl-------------KQGPSLLYVIPI..KPVVLAVQLGAILFQFK.SIYD....FE....YNFVGdLVF....RTFVIFLSLTSFTAFLFNQKILMKAHLVMAIFLLA...GPIACLQYLVFDFYRAE....FHGDnn..lkwDHTSSFENYL.IF...ILVILLAVAL...GSYTWLCHLL.IEGLDE.KN----.--------------------------apkrrpqckicsnhyvvpenekl........
YLH0_CAEEL/1-179                   .................MSKFYDPSQPEQSYDSPKLFGIIPI..KFIVSFLQLVSIVSQIL.WLY-....SE....NDKIY.LVL....LSVGIVLNVFTVVVFIKEHKLLMRAHYYSALIFTV...VPFI-YAVYTFISFIEL....FFGD.......-KDITFNQCS.PF...AYAFIFLCIY...IFYLAMCRVL.IKASEF.QPDDMP.DLDTTQGLFHYNRDAYDGGERAKLMY...............................
E3LSC5_CAERE/9-135                 .............lakk--------------KGPMFFGVLPM..KSVILFMQFLAIFYQTYqFQDC...fGC....FLSTV.YLI....RIILIAVSFIGFIGYLLDRKTVMKVHLWTTIFVLA...IPVAIIQIGVFLY----....----.......----------.--...----------...----------.------.------.--------------------------ctflyicwtissehvisledvlqksasemsl
A0A2G5UHA3_9PELO/4-165             .......isrppklmtw------------------------I..GAIVYSVQALFLIFQF-.WEYV...nKKydpnQSHMQ.MIIelirRIVMIFISGIVFVGFVTEEKVIMKIHILFMTSLLA...IPIT-TLFATVFSFFKS....LEGG.......A-MLINNDGA.KC...INIEGVMCN-...LLYITFCYIL.LADIKYgHPGVLP.Y-------------------------tskvhgssqdsek..................
A0A2H2J2B9_CAEJA/1-50              ................x-------------------------..-----------------.----....--....-----.---....-----------------------------------...-----------------....----.......----------.--...---------L...LFYIWMCYKL.VKAVKR.KTVHLP.EFDTTQGLYQFNRDAYDGVETVTLNY...............................
A0A2H2I2L9_CAEJA/1-105             ..........mqvhfca-------------------------..-----------------.----....--....-----.---....--------------------------ILFALVMTL...FGFGITGALYLYTLIKS....K--D.......GRFGDDGELN.RL...IANFIILVSL...LFYIWMCYKL.VKAVKR.KTVHLP.EFDTTQGLYQFNRDAYDGVETVTLNY...............................
B6IHL7_CAEBR/1-177                 .................MAHFYEP-RDSRLSKAPLCCCCIPI..KFIVLLVQVLALVFQI-.WLLC...aEK....TSNVM.LFV....KVLLAVYTAFTFGVFLIEHKSLMNFHCFLGVICLL...APFA-HVALEYFASAKK....LFLH.......YDYSPKTDV-.-F...VIVGIIMLVV...LVYLTMCRAL.VNELN-.KQNQLPsYVAATQPSFNTEYMP-ELTEKTKLIH...............................
G0MK62_CAEBE/4-179                 ................k-PKFQDLKQSQAIKEEPKFVAFLDNadKVFVLVLQAVLLGHLIYqYVVD....EV....YASKE.WIS....SSIAIGFLAIIFIAFLFEKKSIIVAYSYSLALMAA...IPIGRIELLAADILKKL....FNPDap..vldGPNAMWNASI.II...MWNLIILLAL...GLYLSVCFAV.IDNIDL.KKK---.--------------------------kksmtlphtvqnvil................
G0MK60_CAEBE/1-154                 .................MSKFYET-HFSRSLDSPLLCGCFPI..KPIVLAAQLLMTIFFIH.DLVGt..aSS....ADTVS.IMG....KVFMIIFLVSSFVAFLADYEVLMRLHHLVSCVVAL...IHIA-WFFMELFSFIKK....VASE.......-TPINSSDVK.VL...LVPIGYSFVF...VLYIWMCQQL.IMVLG-.------.--------------------------rkyilp.........................
G0MK59_CAEBE/1-184                 .................MPSYYNPHHPN-VYESPKICCCIPI..KLIVLAIQAAALVFQVY.QICCgierSP....SDKGA.LFL....QFLAALYTGFTFVVFLINHRCLMCTHFCFGICLMM...IPLGFFVYYSFFVVLPG....VLGL.......IDRVGANDIE.QF...FAAGFCILVL...FSYIVMCKVL.IDSLNH.SP-LLP.EH------------------------iinqntqqpghiggghsegsqliy.......
A8XA93_CAEBR/1-186                 .................MVKFYDPSQPEQYLSSPKLFGVLPI..KLIVISMQILYMLLQIV.WLTA...sGV....TSKVS.ILL....VIASVILTAFTVAVFVVENKSLMQAHIWVASLFLF...FPLAVFVLMIAQFFFDI....KFLAt....ffGEGIYTHPIT.SL...TVAAVFLCAY...IAYLFLCHKL.VEAKDQ.QPDDFP.ELDTTQGLFHYNRDAYDGSERVNLIY...............................
E3LSC9_CAERE/1-175                 .................MPRFYDA---SSYSEPPKVC-CIPV..KLVVLFMQIAALILPIA.SICF...aRN....QESHL.LFG....QVLWAIYFGLSFVAFLVEHKGFMVLHCFFGIACWLgacVVIGLEYFKIRVFSDKP....IFNG.......--QFFSNSI-.LL...VGTGILLFVA...LFYIIMCSAL.VRSLGR.-EPVLP.DYNTAM---QQPTCPVDTSEHTKLIY...............................
A0A2G5UIA9_9PELO/1-186             .................MAKFYDPSQPEQYLSSPKLFGVLPI..KLIVISMQILYMLLQIV.WLTA...sDV....TSKVS.ILL....VIASVILTAFTVAVFVVENKSLMQAHIWAASLFLF...VPLAVFVLIIAQFFFDI....KFLAt....flGEGIYTHPIT.SV...VVAAVFLCAY...IAYLFLCHKL.VEAKDQ.QPDDFP.ELDTTQGLFHYNRDAYDGSERVNLIY...............................
A0A2G5UHD3_9PELO/3-156             ...............wt-------------------------..KSFVFSVQAVFLFLQI-.WALAh..fDF....EKNTQ.LIP....RLIMLIVSAIVFIGFLIEQKIIMTVHILFMASFLA...WPIFLLQATILSLFKSLegkaAFIN.......TEGPSTGSMVeTS...VTLFLFSLLN...LVYIACCYNLlVDIKHG.HPEVLP.YNSK----------------------vhgssqasek.....................
A0A2G5UHL6_9PELO/5-174             tkfshpqksekksnmsw------------------------T..KSFVFSVQAVFLFLQI-.WALAh..fDF....EKNTQ.LIP....RLIMLIVSAIVFIGFLIEQKIIMTVHILFMASFLA...WPIFLLQATILSLFKSLegkaAFIN.......TEGPSTGSMVeTS...VTLFLFSLLN...LVYIACCYNLlVDIKHG.HPEVLP.YNSK----------------------vhgssqasek.....................
A0A2G5UHY7_9PELO/5-183             ..tkfshpqkvekesnm----------------------SDI..KAFVFAVQATFFIYQI-.WKLA...hFD...yEKHIQ.LIP....RLTMLFLSAVVIIGFLKKQKIIMTVHIWFMASLMA...WPIFMLHAVVFMFFQSL....EDGDlfinsggDTGINMTGYM.YLklaTAVFIFFLVTlgnLVYIALCYIL.LDDIKYgHPEVLP.YTSMMHGSYQ----------------dsekl..........................
E3LSC4_CAERE/1-179                 .................MPKFYDPNQPEQYLKAPTLFGLFPI..KKVVTVMQIIWLSLQIA.FLSF....VD....LAPLL.ILA....NIVSIVFCAFVIAVFIVENKILMRAHYWSALVFII...VVIGVLLFGTTSILLNV....SAGN.......---FELKSLW.YL...IGGLIFFCAL...VIYASLCRKL.IRALDQ.QPDNLP.DLDTTQGLFHFNRDACDGSERVNLIY...............................
A0A2G5UHB9_9PELO/1-177             .................MAHFYEP-RDSRLSKAPLCCCCIPI..KFIVLLVQVLALVFQI-.WLLC...aEK....TSSGM.LFV....KVLLAVYTAFTFGVFLIEHKSLMNFHCFLGVICLL...APFA-HVALEYFAHINK....FFLH.......RDYSPKTDV-.-F...VIVGLIMLVV...LVYLTMCRAL.VNELN-.KQNQLPsYVAATQPSFNAEYMP-ELTEKTKLIH...............................
A8XA96_CAEBR/1-151                 .................MSNFYER-RVLHSMESPMLCDFIPV..KLVVLVVQIATLLITVG.VISR...nVS....LSSES.AMF....EIFVVVFLVASVVSFLADYELFMHIHYWVVCVLII...VPLY-YWGQSIVNLYNH....IFNN.......---SESPAVF.SF...ATSTFILCSY...IFYIWSCRQL.IISLG-.------.--------------------------rkyvlp.........................
G0MK63_CAEBE/1-184                 .................MVKFYDPNQPEQFLEVPKLCGVFPI..KVLVLAMQFIVMLFQIA.CLCV....FD....SSKTI.IFF....QITSIVLNAFTFAAFIVENKILIRTHYYAAAIFTI...VPIGFVLFSIILMFDVI....FFGNr.....lLTASPFESTF.YL...IAGILVLCAY...IFYITMCRRL.IKAFDR.QPEDLP.ELDTTQGLFTFNRDAYDGAERVKLIY...............................
YLH6_CAEEL/11-169                  .......ekskatisfw-------------------------..KFIAMFIQALFLIGLVEdLCYY...hMF....YSRQY.FFL....EILVTIHTGFSFIVFLIEHKPLIMLHVGYMTLLTI...IPIA-YMVMQGVEFGIL....IFDD.......YHILVFRDFH.KF...GCSIMFSLYY...IGYIVVCFLF.IEALEK.KP-VLP.QVYSI---------------------kpklvaavnpsnn..................
E3LSC6_CAERE/5-188                 ....tkfndsksapnvv-----------QKKKEPMLLG-LSV..KHLILLYHVVFFLVQIDsFIHI....KD....KKFND.IVW....GIITVICISGSFYGILTENKKYIKFHYWYCIFVSA...IPVAFLQLLSVGIIHRL....VTGEe....gfLSGEIMCALK.AF...GYVLGFVMIF...FLYIWMCYKL.HKHLAN.HSMVLPySAKDVHVIYNPNYDAN----------hhsins.........................
A0A2G5UHB1_9PELO/1-151             .................MSNFYER-RVLHSMESPMLCDLIPV..KLVVLVVQIATLLITIG.VLSR...sVS....LSSES.AMF....EIFVVVFLVASVVSFLADYELFMHIHYWVACVLIL...VPLY-YWGQSIVNLYNH....IFNN.......---SESPAVF.SF...ATSTFILCAY...IFYLWACRQL.IISLG-.------.--------------------------rkyvlp.........................
A0A2G5UH99_9PELO/1-165             ..............msd------------------------I..KAFVFAVQATFFIYQI-.WKLA...hFD...yEKHIQ.LIP....RLTMLFLSAVVIIGFLKKQKIIMTVHIWFMASLMA...WPIFMLHAVVFMFFQSL....EDGDlfinsggDTGINMTGYM.YLklaTAVFIFFLVTlgnLVYIALCYIL.LDDIKYgHPEVLP.YTSMMHGSYQ----------------dsekl..........................
YLH7_CAEEL/1-153                   ...........mthfet--------RPLCSLNSPLLCGFFPI..KLAVLLVQLIAIVIQFC.MLYY...nGN....QEEIV.FVA....MVLLLVFTISSFVAFLGEYGTMMAIHYYVSCILLI...WPAVVF-IMKLISLCNK....LFIE.......-ENATSRDAK.DF...MKITAILFAV...IFYIWMCLQL.IRVA--.------.--------------------------ksrlilpr.......................
E3LSC8_CAERE/1-104                 .................MSNFYQT-RVIHSVESPMFFDRFPI..KLLVIVVQVVTLLLNIG.YMSQ....PS....LERGV.FIF....EMCINLFLVASIVAFLADYELLMHIHYWAVCVGTI...IPLIFW-----------....----.......----------.--...----------...----------.------.------.--------------------------glavkdlf.......................
#=GC seq_cons                      ...............................psPhhhshhPl..KhlVlslQhlhllhQI..hlht.....s....tpph..lhh....plhhllhsuhohluFLh-pKhlMphHhahsshhhh...hPlshhhhhhhhhhhph....hhhs........p...hsshh..h...hsshhhhhsh...lhYlhhChtL.lcslp..ps..hP..........................................................
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