GenomeNet

Database: Pfam
Entry: PF18340
LinkDB: PF18340
Original site: PF18340 
#=GF ID   TraI_2B
#=GF AC   PF18340.3
#=GF DE   DNA relaxase TraI 2B/2B-like domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00933
#=GF GA   26.70 26.70;
#=GF TC   26.80 27.10;
#=GF NC   26.40 26.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   28457609
#=GF RT   Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of
#=GF RT   DNA Unwinding during Bacterial Conjugation.
#=GF RA   Ilangovan A, Kay CWM, Roier S, El Mkami H, Salvadori E, Zechner
#=GF RA   EL, Zanetti G, Waksman G;
#=GF RL   Cell. 2017;169:708-721.
#=GF DR   INTERPRO; IPR040668;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the 2B and 2B-like sub-domain found in TraI
#=GF CC   (EC:5.99.1.2) a relaxase of F-family plasmids. It contains four
#=GF CC   domains; a trans-esterase domain that executes the nicking and
#=GF CC   covalent attachment of the T-strand to the relaxase, a vestigial
#=GF CC   helicase domain (carrying the 2B/2B-like sub-domain) that
#=GF CC   operates as an ssDNA-binding domain, an active 5' to 3' helicase
#=GF CC   domain, and a C-terminal domain that functions as a recruitment
#=GF CC   platform for relaxosome components.  The 2B sub-domains in TraI
#=GF CC   are formed by residues 625-773 in the vestigial helicase domain
#=GF CC   and residues 1255-1397 in the active helicase domain. The
#=GF CC   2B/2B-like sub-domain interacts with ssDNA where it contributes
#=GF CC   to the surface area where ssDNA bind. In other words the
#=GF CC   ssDNA-binding site is located in a groove between the 2B and
#=GF CC   2B-like parts of the sub-domain. The sub-domain parts appear to
#=GF CC   act as clamps holding the ssDNA in place, resulting in the ssDNA
#=GF CC   being completely surrounded by protein. In previous studies, the
#=GF CC   2B/2B-like sub-domain of the TraI vestigial helicase domain has
#=GF CC   been identified as translocation signal A (TSA) since it
#=GF CC   contains sequences essential for the recruitment of TraI to the
#=GF CC   T4S system. Thus, the 2B/2B-like sub-domain plays two major
#=GF CC   roles in relaxase function: (1) interacting with the DNA and
#=GF CC   possibly promoting high processivity and (2) mediating
#=GF CC   recruitment of the relaxosome to the T4S system [1].
#=GF SQ   92
#=GS G2H226_9ENTR/44-123         AC G2H226.1
#=GS A0A1X1EMA2_PANCY/745-823    AC A0A1X1EMA2.1
#=GS R9VVE6_9ENTR/764-841        AC R9VVE6.1
#=GS B2VB36_ERWT9/699-777        AC B2VB36.1
#=GS A0A1B6Z6T7_9SPHN/713-800    AC A0A1B6Z6T7.1
#=GS A0A0X8R4V4_9SPHN/719-806    AC A0A0X8R4V4.1
#=GS A0A1E7YZ50_9GAMM/631-710    AC A0A1E7YZ50.1
#=GS H3RL88_PANSE/628-707        AC H3RL88.1
#=GS A0A2A2GVE1_9GAMM/620-697    AC A0A2A2GVE1.1
#=GS A0A437J3F2_9SPHN/719-806    AC A0A437J3F2.1
#=GS A0A0A3ZC26_9GAMM/647-725    AC A0A0A3ZC26.1
#=GS A0A3A1P310_9SPHN/713-800    AC A0A3A1P310.1
#=GS A0A371BIP3_9SPHN/719-806    AC A0A371BIP3.1
#=GS A0A547PA62_9SPHN/407-494    AC A0A547PA62.1
#=GS A0A2A8HWX1_9SPHN/716-803    AC A0A2A8HWX1.1
#=GS A6TIJ2_KLEP7/635-714        AC A6TIJ2.1
#=GS A0A0A3ZQF9_9GAMM/628-707    AC A0A0A3ZQF9.1
#=GS A0A0J8VKS9_9ENTR/718-796    AC A0A0J8VKS9.1
#=GS A0A2N8ZHL7_9VIBR/566-647    AC A0A2N8ZHL7.1
#=GS A0A4R6FU11_9SPHN/719-806    AC A0A4R6FU11.1
#=GS A0A0S6WWK5_9SPHN/624-711    AC A0A0S6WWK5.1
#=GS G6EF33_9SPHN/719-806        AC G6EF33.1
#=GS A0A1W6BB97_9GAMM/630-708    AC A0A1W6BB97.1
#=GS A0A378BVT2_KLEPR/635-714    AC A0A378BVT2.1
#=GS A0A0P7AAK1_9SPHN/713-800    AC A0A0P7AAK1.1
#=GS A0A1E5D171_9VIBR/665-746    AC A0A1E5D171.1
#=GS A0A4P7L5G2_9GAMM/402-479    AC A0A4P7L5G2.1
#=GS A0A514EZI0_9ENTR/484-563    AC A0A514EZI0.1
#=GS W1DQC2_KLEPN/635-714        AC W1DQC2.1
#=GS J2X2D7_KLEPN/239-316        AC J2X2D7.1
#=GS A0A0H4VIP9_9SPHN/717-804    AC A0A0H4VIP9.1
#=GS A0A6I4SY12_9SPHN/713-800    AC A0A6I4SY12.1
#=GS A0A077ZHS7_TRITR/640-719    AC A0A077ZHS7.1
#=GS A0A6I4TIR0_9SPHN/713-800    AC A0A6I4TIR0.1
#=GS A0A074MB68_ERYLO/717-804    AC A0A074MB68.1
#=GS A4WGU6_ENT38/706-784        AC A4WGU6.1
#=GS A0A0H2USH5_SHIFL/43-122     AC A0A0H2USH5.1
#=GS A0A1X1EKI6_PANCY/624-702    AC A0A1X1EKI6.1
#=GS D0Z532_PHODD/691-768        AC D0Z532.1
#=GS A0A0N9V0A9_SPHMC/713-800    AC A0A0N9V0A9.1
#=GS Q93GL4_SALTY/632-711        AC Q93GL4.1
#=GS A0A420EJ79_9SPHN/716-803    AC A0A420EJ79.1
#=GS A0A0B1ZRZ7_9SPHN/716-803    AC A0A0B1ZRZ7.1
#=GS D0Z5E1_PHODD/696-773        AC D0Z5E1.1
#=GS A0A1W7MDA7_9SPHN/717-799    AC A0A1W7MDA7.1
#=GS D4EA24_SEROD/638-717        AC D4EA24.1
#=GS A0A653CIM2_CALMS/308-387    AC A0A653CIM2.1
#=GS A0A0N1LQ56_9SPHN/717-803    AC A0A0N1LQ56.1
#=GS N1MRK4_9SPHN/712-799        AC N1MRK4.1
#=GS A0A220W2X9_9SPHN/717-804    AC A0A220W2X9.1
#=GS A0A0H4VDC5_9SPHN/716-803    AC A0A0H4VDC5.1
#=GS A0A1I5B9V4_9ENTR/637-716    AC A0A1I5B9V4.1
#=GS F1Z8T8_9SPHN/721-807        AC F1Z8T8.1
#=GS A0A1Y3ASG8_EURMA/1419-1498  AC A0A1Y3ASG8.1
#=GS A0A653CKY7_CALMS/635-696    AC A0A653CKY7.1
#=GS A0A377YWM1_KLEPO/633-712    AC A0A377YWM1.1
#=GS A0A6I4L7H6_9ENTR/635-714    AC A0A6I4L7H6.1
#=GS A5P8J2_9SPHN/716-803        AC A5P8J2.1
#=GS F6ILS9_9SPHN/719-806        AC F6ILS9.1
#=GS A0A0H3H1C0_KLEPH/634-713    AC A0A0H3H1C0.1
#=GS A0A1W1Y3B4_9SPHN/104-191    AC A0A1W1Y3B4.1
#=GS J2WZJ0_KLEPN/633-712        AC J2WZJ0.1
#=GS A0A0H4VAQ8_9SPHN/713-800    AC A0A0H4VAQ8.1
#=GS A0A0J8YDH0_9GAMM/674-752    AC A0A0J8YDH0.1
#=GS A0A085FZ02_9ENTR/672-750    AC A0A085FZ02.1
#=GS A0A074MVV8_ERYLO/716-803    AC A0A074MVV8.1
#=GS W1EDJ1_KLEPN/221-300        AC W1EDJ1.1
#=GS A0A2A2GY37_9GAMM/120-169    AC A0A2A2GY37.1
#=GS A0A2V1H7J9_9GAMM/636-715    AC A0A2V1H7J9.1
#=GS A0A0N1BJB2_9SPHN/717-804    AC A0A0N1BJB2.1
#=GS A0A2G8ED26_9GAMM/646-724    AC A0A2G8ED26.1
#=GS A0A5E7Y224_9SPHN/716-803    AC A0A5E7Y224.1
#=GS Q326X3_SHIDS/488-567        AC Q326X3.1
#=GS A0A0M4MX44_9SPHN/717-804    AC A0A0M4MX44.1
#=GS A0A2N1D318_9ALTE/1274-1357  AC A0A2N1D318.1
#=GS Q6LWB7_PHOPR/680-764        AC Q6LWB7.1
#=GS A0A2A2HM84_9GAMM/618-695    AC A0A2A2HM84.1
#=GS A0A239KWJ6_9SPHN/713-800    AC A0A239KWJ6.1
#=GS A0A2N8ZIA6_9VIBR/667-748    AC A0A2N8ZIA6.1
#=GS Q2N5K9_ERYLH/593-680        AC Q2N5K9.1
#=GS A0A2A2GQZ3_9GAMM/628-707    AC A0A2A2GQZ3.1
#=GS A0A2A2SIJ9_9SPHN/720-807    AC A0A2A2SIJ9.1
#=GS G6E714_9SPHN/719-806        AC G6E714.1
#=GS G6EDU4_9SPHN/716-803        AC G6EDU4.1
#=GS A0A0A3ZAC6_9GAMM/649-727    AC A0A0A3ZAC6.1
#=GS A0A2A7U851_EDWTA/632-711    AC A0A2A7U851.1
#=GS A0A0M4MED4_9SPHN/713-800    AC A0A0M4MED4.1
#=GS A0A2N8ZHP8_9VIBR/253-334    AC A0A2N8ZHP8.1
#=GS D0Z588_PHODD/696-773        AC D0Z588.1
#=GS A0A2N8ZNI7_9VIBR/667-748    AC A0A2N8ZNI7.1
#=GS A0A4P7L7M4_9GAMM/628-707    AC A0A4P7L7M4.1
#=GS A0A3N5DJ29_9SPHN/716-803    AC A0A3N5DJ29.1
G2H226_9ENTR/44-123                    ....VLQPVWLDSKSRHQRENYRAGMMM.EQWDN...eKKAMHR.....YQIDKVIDNSNT.LR.LISETGQVRAEKINKLD.S.....SWSLFAQKQIAV.................
A0A1X1EMA2_PANCY/745-823               ....ARTPVFITAKERKLPASYRPGMVL.EDRSD....RQEIRH.....YMIDRVHDDTRM.LS.LIDGDGVLSRVKLSTLT.A.....DWRLFTREQLSI.................
R9VVE6_9ENTR/764-841                   ....ARTPVWLDSKTRRMSGSYRAGQVL.EDRTE....-RETRH.....YVIDRVHEDTRV.LS.LIDGDGVLVRMKIADLT.A.....DWRLYQREQLHI.................
B2VB36_ERWT9/699-777                   ....ARNEVFMTIAEKKKVASWRTGYVI.EDRTE....-RKPQV.....YTVGSIAEETKS.LI.LYNDKGERSTVKASAMGrK.....DVRVFESTMIEV.................
A0A1B6Z6T7_9SPHN/713-800               ....TLSRINLTREELRYISAYSPGMIL.EMAQVnrsqKLHKGQ.....YTVKSMNESRKE.IW.LTDWKGRKHRLRPTQLR.ShgnddKVALYEKKDL--ti...............
A0A0X8R4V4_9SPHN/719-806               ....VLSRVNLTREEMRYARSYAAGMVL.EVDRRqrgqGLQRGR.....YEVIATDPSRER.VM.LQNERGKRFEFRPGQMR.PqgeqdPLRLFEVRPLE-i................
A0A1E7YZ50_9GAMM/631-710               ....TLEPVWLDSRHQQVRDHYREGMVM.ERWNA...eARSRER.....FVIDRVTGRNNS.LT.LRNAQGETRVTRLSELN.S.....SWSLYRTGTLQV.................
H3RL88_PANSE/628-707                   ....TLVPQWLDSKNRRQLDTYREGMVL.EQRAP...dSRVSQR.....YTVDRVSAETRS.LI.LVGEDGQRQGLKLGQVD.S.....SWSLYRPQTVD-i................
A0A2A2GVE1_9GAMM/620-697               ....TKKSIFLDAANRNQRNTYNIGMIL.ERTTE....-NERQQ.....YQIKSISKQSNK.LL.LQDRFGNTSALSINKID.S.....HYRLFKVQEMEL.................
A0A437J3F2_9SPHN/719-806               ....VLSRINLTREEMRYARSYAAGMVL.EVDRRqrgqGLQKGR.....YEVVEIDPTRER.VM.LQNERGKRFEFRPGQMR.PqgdqdPLRLFEVRPLE-i................
A0A0A3ZC26_9GAMM/647-725               ....VREPVWLDAASRNDRTKYREDMVL.EHHTG....QGEHAD.....FTITGVSERHNL.LT.LSDEKGQTQGLKISDID.S.....HWRLFSEKKLEL.................
A0A3A1P310_9SPHN/713-800               ...v-LDRANLTREELRYLAAYKPGMVL.EVAKLeralGLKRGE.....YTVRKVDDRKVS.VE.LEDRQGKLHQLKPSRIG.RmgkddNLALFDRRKLE-i................
A0A371BIP3_9SPHN/719-806               ....TLSRVNVTREELRYAKSYAPGMLV.EVARR....QRTQ-GlhegrYRVASVDAGQGS.IT.LENQRGKQFVFRPGQLR.PqgeqdPLRLFEPKPL--dl...............
A0A547PA62_9SPHN/407-494               ....VLSRVNTTREELRYARNYQPGMVL.EVASR....-QSRHRlgrgsHEIAAVDTEKGV.VT.LRDERGHLRRFVPARLS.AkgndqTLQLFEQKDL--dl...............
A0A2A8HWX1_9SPHN/716-803               ..ih--SRVNVTHEELRYLRTYQRGMVL.NFRSR....-DSTQKlskgdYTVKTIDQARKQ.LV.LEDRKGRLRNFNPARLRpGad.dsRLSLFDRKSIS-i................
A6TIJ2_KLEP7/635-714                   ....ALTPVWLDSKSRGVRDYYREGMVM.ERWDP...eNRTHDR.....FVIDRVTASSNM.LT.LKDRDGVRLDLKVSAVD.S.....QWTLFRAETLPV.................
A0A0A3ZQF9_9GAMM/628-707               ...m-LVPQWLDSKNRRQLDTYREGMVL.EQRAP...dSRAPQR.....YTIDRVSAETRT.LM.LVGEDGQRQGMKLSQVD.S.....SWSLYRSQSVD-i................
A0A0J8VKS9_9ENTR/718-796               ....ARTPVWLDSKTRRQPGSYRAGQVL.EDRSD....AREVKH.....YVIDRVHDDTRM.LS.LVDGDGVLSRHKISSLT.A.....DWRLYNSEQLNI.................
A0A2N8ZHL7_9VIBR/566-647               ...t-QTPHSLSKAQQPLVQHYKPGMTL.THWEK....-NKPQS.....FVIASIDKESNT.MTaLSKRDGQSHRFDPSSRAfKn...mKMQINKPQSLN-i................
A0A4R6FU11_9SPHN/719-806               ....VLSRVNLTREEMRYARSYATGMVL.EVDRRqrgqGLQKGR.....YEVVETDPTRER.VM.LQNERGKRFEFRPGQMR.PqgeqdPLRLFEVRPLE-i................
A0A0S6WWK5_9SPHN/624-711               ...v-HSRVNVTHEELRYLRTYQPGMVL.NFRSR....-DSTQElskgdYTVKTIDQARKQ.LV.LEDRKGRLRKFNPARLRpGav.dsRLSLFDRKSLS-i................
G6EF33_9SPHN/719-806                   ....VLSRVNLTREEMRYSRSYAAGMVL.EVDRRqrgqGLQKGR.....YDVVETDPTRER.VM.LQNERGKRFEFRPSQMR.PqgeqdPLRLFEVRPLE-i................
A0A1W6BB97_9GAMM/630-708               ....VRVPVWLDATNRNDRSVYRAGMVL.EQHEG....QGQKSV.....FTITGVSERHNL.LT.VSDEKGQKHGISISSID.S.....HYRLFREKKLEL.................
A0A378BVT2_KLEPR/635-714               ....ALTPVWLDSKSRGVRDYYREGMVM.ERWDP...eTRTHDR.....FVIDRVTASSNM.LT.LKDREGDRLDLKVSAVD.S.....QWTLFRADTLPV.................
A0A0P7AAK1_9SPHN/713-800               ....VLDRVNLTREELRYFDAYKPGMVL.EVAKLeralGLKRGE.....YAVRKVDDRKNT.VE.LEDKQGRLHKLMPSRIG.RtgkddNLSLFDRRNLEI.................
A0A1E5D171_9VIBR/665-746               ...t-QVPHYLSKAQQPLVQHYKPGMVL.THWDK....-GKPQS.....FVIASTDKESNTmIA.LSKKDGETIHFDPSSRAfKa...mTMQISKPQ----glni.............
A0A4P7L5G2_9GAMM/402-479               ....TRKSVFLDASNSNNRNTYQVGNQL.EKING....-EQKKT.....FLIKDIDKKTNT.LV.LLNSDGCYTQLPINKIS.N.....HYQLYKTETLEL.................
A0A514EZI0_9ENTR/484-563               ....ALTPVWLDSKSRGVRDYYREGMVM.ERWDP...eARKHDR.....FVIDRVTASSNM.LT.LRDKEGERLDMKVSAVD.S.....QWTLFRADKLTV.................
W1DQC2_KLEPN/635-714                   ....ALTPVWLDSKSRGVRDYYREGMVM.ERWDP...eNRTHDR.....FVIDRVTASSNM.LT.LKDRDGVRLDLKVSAVD.S.....QWTLFRAETLPV.................
J2X2D7_KLEPN/239-316                   ....TLSPVWLDGANRNLRSTYQTGMVL.ERYEG....KELKET.....LKITGINDNHNT.LR.VVNEHGETQGLRLNAID.S.....QYRLYTGMTI--s................
A0A0H4VIP9_9SPHN/717-804               ....VLSRVNATREELRYARNYAPGMVL.EVASR....-QSRHRlgrgsHEIAAVDTEKGV.VT.LRDERGHLRRFVPARLS.A.....------------kgsdqilqlfekkdldl
A0A6I4SY12_9SPHN/713-800               ....VLDRVNVTREELRHMSAYRTGRVL.EVLRR....-EKALNlrpglYRIRGWERKGRQ.VL.LEDKDGKQARLDPSRIKvTed.rdNLALLEPRKLE-v................
A0A077ZHS7_TRITR/640-719               ....ALSPVWLDSRSRYLRDMYRPGMVM.EQWNP...eTRSHDR.....YVTERVTAQSHS.LT.LRNAQGETQVVRISSLD.S.....SWSLFRPEKMPV.................
A0A6I4TIR0_9SPHN/713-800               ....VLDRVNFTREELRYLAAYRPGMVL.EVAKAeralGLKPGE.....YAVRGIDEAKGV.VR.LRDDRGCQHAFRPGRMR.KtgkddNLALLERRKL--ev...............
A0A074MB68_ERYLO/717-804               ....VLTRVNATREELRYARNYAPGMVL.EVASR....-QSRHGlgrgsHEVAAIDTEKGV.VT.LRDERGHLRRFVPARLS.AkgsdqTLQLFEKKDL--dl...............
A4WGU6_ENT38/706-784                   ....ARQPVWLDTKTRRMSGSYRPGMVL.EDRSD....KKERHS.....YVIDRVHEDTRM.LS.LIDGDGVLTRMKISEVT.A.....DWRLYNRETLSV.................
A0A0H2USH5_SHIFL/43-122                ....ALSPVWLDSRSRYLRDMYRPGMVM.EQWNP...eTRSHDR.....YVTERVTAQSHS.LT.LRNAQGETQVVRISSLD.S.....SWSLFRPEKMPV.................
A0A1X1EKI6_PANCY/624-702               ....ARIPVWLDVSNRNDRRSYREGMVL.EHIQR....NGLIDS.....FTVTGISEKLNL.LT.LSDDKGQVHGLKIRDVD.S.....GWRLFREKKLQI.................
D0Z532_PHODD/691-768                   ....TLNPVFMSPEQQRSIKSYQKGMVI.SQVND....-GKVER.....YTVEKVNSRAQT.LQ.LLDGDNNRSYVNVKENT.T.....PYFVSQPAKIEV.................
A0A0N9V0A9_SPHMC/713-800               ...v-LDRANLTREELRYLAAYRPGMVL.EVAKLeralGLKRGD.....YLVRKVDDRKGI.VE.LEDKHGRLSKLNPSRIG.HagkddNLALFDRRHLE-v................
Q93GL4_SALTY/632-711                   ....ALSPVWLDSRNRYLRDMYREGMVM.EQWNP...eKRSHDR.....YVIDRVTAQSHS.LT.LRDAQGETQMVRISALD.S.....SWSLFRPEKMPV.................
A0A420EJ79_9SPHN/716-803               ...v-HSRVNVTPEELRYLRTYQPGMVL.NFRSR....-DSTQKlsmgdYTVKTIDHARKQ.LV.LEDRKGRLRKFNPARLRpGad.dsRLSLFERKSLS-i................
A0A0B1ZRZ7_9SPHN/716-803               ...v-HSRVNVTHEELRYLRTYQPGMVL.NFRSR....-DSTQKlskgdYTVKTIDEARRQ.LV.LEDSKGRLRKFNPARLRpGad.dsRLSLFERKPLS-i................
D0Z5E1_PHODD/696-773                   ....TLNPVFMSPEQQRSIKSYQKGMVI.SQVND....-GKVQQ.....YTVEKVNSRAQT.LQ.LLDSDNNRSYLNVKESS.T.....PYFVSQPDKIEV.................
A0A1W7MDA7_9SPHN/717-799               ....VLSRVNGTREELRQTATYEPGMVL.ELTTR....-QTRQHlgkgrYDIVQVDAGKGQ.VT.LRDAHGRSHTFTPSRLG.-.....------------ttgdnqaiqlher....
D4EA24_SEROD/638-717                   ....TLTPVWLDSKNRGAIDTYREGMVM.ERWDA...dSKQRER.....FVIDRVGAQTRN.LV.LRSAAGEKQTLAVRELD.K.....DWSLFRPGIIAV.................
A0A653CIM2_CALMS/308-387               ....TLEPVWLDSRHQQVRDHYREGMVM.ERWNA...eARSRER.....FVIDRVTGRNNS.LT.LRNAQGETRVTRLSELN.S.....SWSLYRTGTLQV.................
A0A0N1LQ56_9SPHN/717-803               ....VLSRVNATREELRQVRTYAPGMVL.EVTAR....-QSRQNlakgrYDVLKVDPANGT.VE.LRDAKGHRQTFLPSRIA.A.....------------rgdnealqlherkalt.
N1MRK4_9SPHN/712-799                   ....VLSRVNATREELRYVSAYRPGMVL.DVRSP....-DKHQRlprgeYKVDRIDEKTRE.VF.LVDGKGKARTLRPSRIR.SgakddRLALFEEKRLS-i................
A0A220W2X9_9SPHN/717-804               ..tf--SRVNSTREELRYIHSYKPGMMI.ELKAP....-DRSQRlgkgqYDVVSVDERAKQ.LV.LKDRGGRERSFQVSKLR.AnasedQIALYEKKQLD-i................
A0A0H4VDC5_9SPHN/716-803               ...v-HSRVNATREELRYIGTYRAGMVL.NVRSR....-DSSQKlskgdYTVKSIDHAKKR.VV.LEDRKGRQYKFSPSRLRpGas.ddRFSLFELKSLDV.................
A0A1I5B9V4_9ENTR/637-716               ....TLSPVWLDSKNRKSRDTYREGMVM.ERWNA...dEKNMER.....WRIDRVGAETSV.LR.LVNEAGEQQHQKISQID.A.....SWSLFKSRTLEV.................
F1Z8T8_9SPHN/721-807                   ...r-LESVNLTREEMRYASHYRSGQVL.EVIGRdrpaGLERGT.....YDVVGVSAK-GV.VS.LRDAEGKRVRFRPDRLDpTdk.rdHLALFERETLR-l................
A0A1Y3ASG8_EURMA/1419-1498             ....TLTPVWLDSKNRGAIDTYREGMVM.ERWDA...dSKQRER.....FVIDRVGAQTRN.LV.LRSVAGEKQTLAVRELD.K.....DWSLFRPGTVAV.................
A0A653CKY7_CALMS/635-696               ..pg--------------------GMVM.ERWNA...eARSRER.....FVIDRVTGRNNS.LT.LRNAQGETRVTRLSELN.S.....SWSLYRTGTLQV.................
A0A377YWM1_KLEPO/633-712               ....ALSPVWLDSRSRYLRDMYRPGMVM.EQWNP...eTRSHDR.....YVIDRVTAQSHS.LT.LRDAQGETQVVRISSLD.S.....SWSLFRPEKMPV.................
A0A6I4L7H6_9ENTR/635-714               ....ALTPVWLDSKSRGVRDYYREGMVM.ERWDP...eNRTHDR.....FVIDRVTASSNM.LT.LKDRDGVRLDLKVSAVD.S.....QWTLFRADTLPV.................
A5P8J2_9SPHN/716-803                   ...v-HSRVNVTNEELRYLRTYQPGMVL.NFRSR....-DSTQKlskgdYTVKTIDHARKQ.LV.LEDRKGRLRKFNPARLRpGav.esRLSLFERKSLSI.................
F6ILS9_9SPHN/719-806                   ....VLSRVNLTREEMRYSRSYAAGMVL.EVDRRqrgqGLQKGR.....YEVIETDPTRER.VM.LQNERGKRFEFRPGQMR.PqgdqdPLRLFEVRPLE-i................
A0A0H3H1C0_KLEPH/634-713               ....ALTPVWLDSKSRGVRDYYREGMVM.ERWDP...eTRTHDR.....FVIDRVTASSNM.LT.LKDREGDRLDLKVSAVD.S.....QWTLFRADTLPV.................
A0A1W1Y3B4_9SPHN/104-191               ....VLSRINTTQEELRHAATYQPGMVV.EVERD....-KRAQGlsrgmYTVVGVDARRER.VE.LENERGKRFEFRPDKLRpQge.hdALRLYERKELS-l................
J2WZJ0_KLEPN/633-712                   ....ALSPVWLDSRSRYLRDMYRPGMVM.EQWNP...eTRSHDR.....YVIDRVTAQSHS.LT.LRDAQGETQVVRISSLD.S.....SWSLFRPEKMPV.................
A0A0H4VAQ8_9SPHN/713-800               vldl----ANLTREELRYLAAYKPGMVL.EVAKLeralGLKRGE.....YAVRKVDDRKEI.VE.LEDRQGRLHKLKPSRIG.RtgkddNLALFDRRELEV.................
A0A0J8YDH0_9GAMM/674-752               ...s-RTPVFLDTKTRRLAGSYRPGMVL.EDRSG....KNETRH.....YTVDRVHPDTRM.LS.LVDGDGVLSRVKLSGLT.G.....DWRAFTTENISV.................
A0A085FZ02_9ENTR/672-750               ....ARQPVWLDSKTRRMPGSYRAGMVL.EDRSD....AKERQS.....YVIDRVHEDTRV.LS.LIDGDGVLTRMKISDVT.P.....DWRLFNRETLNV.................
A0A074MVV8_ERYLO/716-803               ...v-HSRVNATREELRYPGTYRAGMVL.NVRSR....-DSSQKlskgdYTVQSIDHARKR.VM.LEDRKGRKHTFSPSRLRpSgs.edRFSLFERKSLR-l................
W1EDJ1_KLEPN/221-300                   ....ALTPVWLDSKSRGVRDYYREGMVM.ERWDP...eNRTHDR.....FVIDRVTASSNM.LT.LKDREGGRLDLKVSAVD.S.....QWTLFRADTLPV.................
A0A2A2GY37_9GAMM/120-169               ....TKKSIFLDAANHNQRNTYNIGMIL.ERNTE....-NERQQ.....YQITRISKQK--.--.-----------------.-.....------------accliv...........
A0A2V1H7J9_9GAMM/636-715               ....VLTPVWLDSKSRSSRENYREGMVM.ERYDS...eAKKRER.....FVIDRVTHRSHS.LT.LVDQEGKAEVIRLSQLD.S.....SWSLYQSTIMPV.................
A0A0N1BJB2_9SPHN/717-804               ....VLSRVNTTREELRHVGTYEPGMVL.ELTAR....-QTRQHlgkgrYDIVQVDAGKGQ.VT.LRDAHGRSHTFTPSRLG.A.....------------tgdnqavqlherksltl
A0A2G8ED26_9GAMM/646-724               ....VREPVWIDAATRNDRSKYREGMVL.EHHTG....RGLMED.....FTITGVSEKHNL.LT.LSDAKGHTQGLKISDID.S.....HYRLYREKKLEL.................
A0A5E7Y224_9SPHN/716-803               ....VLSRVNATREELRHLHVYQPGMVL.DLRSR....-DSTQKlskghYTVNTVDHARKR.IV.LEDKKGRLRTFTPARLRpGad.gdRLSLFERRQLA-l................
Q326X3_SHIDS/488-567                   ....ALSPVWLDSRSRYLRDMYRPGMVM.EQWNP...eTRSHDR.....YVTERVTAQSHS.LT.LRNAQGETQVVRISSLD.S.....SWSLFRPEKMPV.................
A0A0M4MX44_9SPHN/717-804               ....VLSRVNATREELRYARNYQPGMVL.EVASR....-QSRHDlgrgsHEVAAVDTEKGV.VT.LRDERGHLRRFVPAKLS.SkgsdqTLQLFEKKDL--dl...............
A0A2N1D318_9ALTE/1274-1357             ....TLTPVFLSPQQKQVASEYKVGQIIlFNRNGekngFTRQES.....YVVEKVDSQSNN.II.LRSPSGT-HTVSVHELHtN.....GFSVAAVTK---tei..............
Q6LWB7_PHOPR/680-764                   ....TLNPVFLSDAQREVVSHYKKGMVL.SEWQKv.hgRNTKQD.....FTVTAINRKNNL.LT.LKDSKGKTQDINPNTRE.Ak..arQFSISRSDSIEI.................
A0A2A2HM84_9GAMM/618-695               ....TRKSVFLDASNRNNRNTYQVGNQL.EKING....-EQKEA.....FLIKDIDKKSNT.LV.LSNADGRYTLLPINKIS.N.....HYQLYKTEPLEL.................
A0A239KWJ6_9SPHN/713-800               ..vh--SRMNVTHEELRYLRTYQPGMVL.NFRSR....-DSTQKlskgdYTVKTIDHARKQ.LV.LEDRKGRVRKFNPARLRpGav.esRLSLFERKSLSI.................
A0A2N8ZIA6_9VIBR/667-748               ...t-QTPHSLSKAQQPLVQHYKPGMTL.THWEK....-NKPQS.....FVIASIDKESNT.MTaLSKRDGQSHRFDPSSRAfKn...mKMQINKPQSLN-i................
Q2N5K9_ERYLH/593-680                   ...v-HSRVNATREELRYMGTYSAGMVL.NVRSR....-DSSQKlskgdYTVKSIDHTRKR.VM.LEDRKGRKHTFSPTRLRpGgs.ddRFSLFERKS---frl..............
A0A2A2GQZ3_9GAMM/628-707               ....TLKPQWLTAKSRTSRDSYREGWVM.ECWDS...eKKSKER.....FIIDRVTAVSNT.LT.LINQHGEQRLEKISQLN.S.....NWSLYQPVKIAI.................
A0A2A2SIJ9_9SPHN/720-807               ....VLDRVSLTNEELRYVQSYQPGQVV.EIAQA....-QRGQRlprakATVERVDGKRGT.VT.LRLSGGRERTFRPAKLR.ArdgetPIQLYERKELEL.................
G6E714_9SPHN/719-806                   ....VLSRVNLTREEMRYSRSYAAGMVL.EVDRRqrgqGLQKGR.....YEVVETDPTREH.VM.LQNERGKRFEFRPGQMR.PqgeqdPLRLFEVRPLE-i................
G6EDU4_9SPHN/716-803                   ...a-HSRVNVTHEELRYLRTYQSGMVL.NFRSR....-DSTQKlskgdYTVKTIDQARKQ.LV.LEDRKGRVRKFNPARLRpGad.dsRLSLFERKSLS-i................
A0A0A3ZAC6_9GAMM/649-727               ....VREPVWLDAASRNDRTKYREGMVL.EHHTG....EGEQAD.....FTITGVSERHNL.LT.LSDEKGQTQGLKISDID.S.....HYRLFSEKKLEL.................
A0A2A7U851_EDWTA/632-711               ....ALEPVWLDSKNRLSRDTYRVGMVM.ERWDA...eSKTATR.....YVIDRVTARSHT.LT.LRDEQGATQTLRLSSLD.S.....RWSLYQPQTLAV.................
A0A0M4MED4_9SPHN/713-800               ...v-HSRVNVTHEELRYLRTYQPGMVL.NFRSR....-DSTQKlskgdYTVKTIDHARKQ.LV.LEDRKGRVHKFNPARLRpGav.esRLSLFERKSLSI.................
A0A2N8ZHP8_9VIBR/253-334               ...t-QTPHSLSKAQQPLVQHYKPGMTL.THWEK....-NKPQS.....FVIASIDKESNT.MTaLSKRDGQSHRFDPSSRAfKk...mKMQINKPQSLN-i................
D0Z588_PHODD/696-773                   ....TLNPVFMSPEQQRSIKSYQKGMVI.SQVND....-GKVQQ.....YTVEKVNSRAQT.LQ.LLDSDNNRSYLNVKESS.T.....PYFVSQPDKIEV.................
A0A2N8ZNI7_9VIBR/667-748               ...t-QTPHSLSKAQQPLVQHYKPGMTL.THWEK....-NKPQS.....FVIASIDKESNT.MTaLSKRDGQSHRFDPSSRAfKk...mKMQINKPQSLN-i................
A0A4P7L7M4_9GAMM/628-707               ....TLKPQWLTAKSRISRDSYREGWVM.EYWDS...eKKSKER.....FIIDRVTAVSNT.LT.LINQHGEQRLEKITQLN.S.....HWSLYQPAKIAI.................
A0A3N5DJ29_9SPHN/716-803               ...v-HSRVNVTHEELRYLRTYQPGMVL.NFRSR....-DSTQKlskgdYTVKTIDHARKQ.LV.LEDRKGGLRKFNPARLRpGad.dsRLSLFERKPLS-i................
#=GC seq_cons                          ....sLo.V.LspcphphhssYcsGMVL.Ehhst.....pppp+.....YslcpVstpppp.Ls.LpDpcGcppphcsuplc.u.....phpLactcpLp..................
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