GenomeNet

Database: Pfam
Entry: PF18809
LinkDB: PF18809
Original site: PF18809 
#=GF ID   PBECR1
#=GF AC   PF18809.3
#=GF DE   phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Iyer LM
#=GF GA   27.60 27.60;
#=GF TC   28.00 27.80;
#=GF NC   26.50 26.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0688
#=GF RN   [1]
#=GF RM   28559295
#=GF RT   Polyvalent Proteins, a Pervasive Theme in the Intergenomic
#=GF RT   Biological Conflicts of Bacteriophages and Conjugative Elements.
#=GF RA   Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;
#=GF RL   J Bacteriol. 2017; [Epub ahead of print]
#=GF DR   INTERPRO; IPR041092;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   A predicted endoRNase of the Barnase-EndoU-ColicinE5/D-RelE like
#=GF CC   nuclease fold found in polyvalent proteins of phages and
#=GF CC   conjugative elements. The predicted active site contains a
#=GF CC   conserved histidine and threonine residues [1].
#=GF SQ   102
#=GS H5VD09_HELBI/64-171         AC H5VD09.1
#=GS F4GI46_SPHCD/1177-1264      AC F4GI46.1
#=GS R5IJ41_9BACT/2451-2536      AC R5IJ41.1
#=GS C8PBL3_9LACO/31-133         AC C8PBL3.1
#=GS R6AAX6_9BACT/5487-5585      AC R6AAX6.1
#=GS A0A268TAT0_9HELI/1550-1632  AC A0A268TAT0.1
#=GS A0A285M8H9_9RHIZ/344-434    AC A0A285M8H9.1
#=GS A0A3D8HL62_9HELI/594-687    AC A0A3D8HL62.1
#=GS I7GTU7_9HELI/427-521        AC I7GTU7.1
#=GS H5VDY6_HELBI/1-82           AC H5VDY6.1
#=GS A0A4R1KXL8_9PAST/905-1014   AC A0A4R1KXL8.1
#=GS T1CYV3_9HELI/137-244        AC T1CYV3.1
#=GS A0A268TAT0_9HELI/249-335    AC A0A268TAT0.1
#=GS A0A1T0CD61_9GAMM/1534-1643  AC A0A1T0CD61.1
#=GS V8CKN9_9HELI/2129-2241      AC V8CKN9.1
#=GS A0A3D8HK68_9HELI/74-168     AC A0A3D8HK68.1
#=GS A0A268TAT0_9HELI/1025-1117  AC A0A268TAT0.1
#=GS A0A1T0CEJ0_9GAMM/558-667    AC A0A1T0CEJ0.1
#=GS A0A2M9P9Q3_9RHOB/3-89       AC A0A2M9P9Q3.1
#=GS A0A128EG14_9PROT/701-798    AC A0A128EG14.1
#=GS A0A1I5JYX0_9RHIZ/352-442    AC A0A1I5JYX0.1
#=GS A0A268TAT0_9HELI/1729-1820  AC A0A268TAT0.1
#=GS C8PFM4_9PROT/308-353        AC C8PFM4.1
#=GS A0A2W6MUX0_9HELI/1993-2090  AC A0A2W6MUX0.1
#=GS A0A377PTN5_9HELI/1482-1578  AC A0A377PTN5.1
#=GS A0A329ZK83_9HELI/21-112     AC A0A329ZK83.1
#=GS A0A329ZLR2_9HELI/21-131     AC A0A329ZLR2.1
#=GS A0A4R2PKI5_9SPHN/632-730    AC A0A4R2PKI5.1
#=GS A0A2P2E1H6_9LEPT/12-81      AC A0A2P2E1H6.1
#=GS A0A1I5MUW3_9RHIZ/345-435    AC A0A1I5MUW3.1
#=GS A0A3D8HK17_9HELI/38-144     AC A0A3D8HK17.1
#=GS V2RHE7_9BACT/4-100          AC V2RHE7.1
#=GS A0A329ZLH2_9HELI/1-60       AC A0A329ZLH2.1
#=GS A0A2N5XTW7_9RHIZ/348-439    AC A0A2N5XTW7.1
#=GS A0A268TAT0_9HELI/2324-2419  AC A0A268TAT0.1
#=GS A0A1S5RFJ7_9CAUD/124-234    AC A0A1S5RFJ7.1
#=GS F8KPC8_HELBC/840-950        AC F8KPC8.1
#=GS F8KPC8_HELBC/664-758        AC F8KPC8.1
#=GS F8KPC8_HELBC/1146-1267      AC F8KPC8.1
#=GS A0A0B6RLQ4_BURPL/46-154     AC A0A0B6RLQ4.1
#=GS F2NT52_TRES6/26-130         AC F2NT52.1
#=GS F8KQN1_HELBC/238-328        AC F8KQN1.1
#=GS U5N8C9_9BURK/92-183         AC U5N8C9.1
#=GS O34410_HELPY/822-926        AC O34410.1
#=GS A0A2T5ITA8_9LACT/60-164     AC A0A2T5ITA8.1
#=GS A0A068YTK5_9BURK/79-185     AC A0A068YTK5.1
#=GS A0A0M2RGV4_9PROT/166-260    AC A0A0M2RGV4.1
#=GS A0A3R6F3B8_9BACT/1088-1178  AC A0A3R6F3B8.1
#=GS E7G4N4_9HELI/1-100          AC E7G4N4.1
#=GS A0A1S5RF23_9CAUD/1622-1726  AC A0A1S5RF23.1
#=GS A0A3D8HMP7_9HELI/189-284    AC A0A3D8HMP7.1
#=GS A0A268TBU3_9HELI/39-129     AC A0A268TBU3.1
#=GS A0A4R2N7R4_9BURK/1698-1806  AC A0A4R2N7R4.1
#=GS T1D0F0_9HELI/36-128         AC T1D0F0.1
#=GS A0A1S5RGE7_9CAUD/1608-1719  AC A0A1S5RGE7.1
#=GS A0A2S5AK18_9PAST/664-774    AC A0A2S5AK18.1
#=GS H5VDH4_HELBI/404-496        AC H5VDH4.1
#=GS A0A377PSD9_9HELI/1730-1831  AC A0A377PSD9.1
#=GS A0A5M6ICD2_9PROT/1789-1879  AC A0A5M6ICD2.1
#=GS A0A3D8HKN7_9HELI/1445-1540  AC A0A3D8HKN7.1
#=GS A0A1V3TVA0_9PAST/598-708    AC A0A1V3TVA0.1
#=GS A0A3N0V610_9PROT/2027-2125  AC A0A3N0V610.1
#=GS A0A1B8J8C8_9HELI/172-271    AC A0A1B8J8C8.1
#=GS A0A3D8HJX2_9HELI/38-130     AC A0A3D8HJX2.1
#=GS A0A4U8U564_9HELI/985-1075   AC A0A4U8U564.1
#=GS A0A084INL0_SALHC/1283-1395  AC A0A084INL0.1
#=GS A0A4U8UAP2_9HELI/22-123     AC A0A4U8UAP2.1
#=GS A0A5C1E782_9RHOO/1174-1271  AC A0A5C1E782.1
#=GS H5VCR0_HELBI/129-240        AC H5VCR0.1
#=GS A0A0U1L3A3_9FIRM/2760-2863  AC A0A0U1L3A3.1
#=GS A0A426K2U4_9FLAO/1202-1302  AC A0A426K2U4.1
#=GS A0A3D8HKJ7_9HELI/263-362    AC A0A3D8HKJ7.1
#=GS A0A329ZK91_9HELI/1-60       AC A0A329ZK91.1
#=GS A0A1B8J876_9HELI/106-202    AC A0A1B8J876.1
#=GS R7BYY7_9BURK/188-302        AC R7BYY7.1
#=GS A0A1S5RG15_9CAUD/930-1037   AC A0A1S5RG15.1
#=GS A0A4U8U7Q6_9HELI/531-585    AC A0A4U8U7Q6.1
#=GS V8CKN9_9HELI/1061-1162      AC V8CKN9.1
#=GS A0A4V6YSL7_9HELI/85-183     AC A0A4V6YSL7.1
#=GS A0A2W6MUX0_9HELI/1284-1383  AC A0A2W6MUX0.1
#=GS Q775D4_BPBPP/642-732        AC Q775D4.1
#=GS A0A329ZL52_9HELI/290-352    AC A0A329ZL52.1
#=GS A0A2M8RXZ8_9PAST/780-890    AC A0A2M8RXZ8.1
#=GS A0A329ZN80_9HELI/21-107     AC A0A329ZN80.1
#=GS A0A377PSD9_9HELI/2154-2245  AC A0A377PSD9.1
#=GS A0A1S5RG62_9CAUD/953-1060   AC A0A1S5RG62.1
#=GS A0A268TWB6_9HELI/206-315    AC A0A268TWB6.1
#=GS F8KRJ3_HELBC/162-254        AC F8KRJ3.1
#=GS A0A2N3I809_9BACT/637-736    AC A0A2N3I809.1
#=GS H5VCV2_HELBI/565-677        AC H5VCV2.1
#=GS A0A4U8UAP2_9HELI/387-496    AC A0A4U8UAP2.1
#=GS A0A268TAT0_9HELI/417-504    AC A0A268TAT0.1
#=GS A0A1S5RFE0_9CAUD/940-1047   AC A0A1S5RFE0.1
#=GS H5VC03_HELBI/2-117          AC H5VC03.1
#=GS A0A1H2PQZ3_9BURK/701-792    AC A0A1H2PQZ3.1
#=GS A0A4U8U7Q6_9HELI/503-537    AC A0A4U8U7Q6.1
#=GS A0A268TZF4_9HELI/296-402    AC A0A268TZF4.1
#=GS A0A2W6MUX0_9HELI/1647-1751  AC A0A2W6MUX0.1
#=GS A0A3D8HKN7_9HELI/1800-1897  AC A0A3D8HKN7.1
#=GS A0A5Q0BHF7_9GAMM/33-124     AC A0A5Q0BHF7.1
#=GS A0A268TAT0_9HELI/709-794    AC A0A268TAT0.1
#=GS A0A1L3ZV74_9SPHN/540-630    AC A0A1L3ZV74.1
H5VD09_HELBI/64-171                    .................AFYREDL......GYIDLVWGN.........-VGVGK..TKGIGLSKILDKHAD..DFKGFVg......nTPE.EKVASGIKKIIDQ.GE-LK..EV.D...GVKTIYLNH....KENIFKVGLSQGWDH....E....GNN...HWVITAYKVRT--ps.............
F4GI46_SPHCD/1177-1264                 .................AMYKEGI......GDIDFVYGK.........----PG..ETGYGLAHIQEKHP-..------........---.-NILPRLVELIET.GVVSA..PS.K...DRRNILLLE....----ARAAIRLDWNG....E....KKN...-WLVTAYYY----dnhl...........
R5IJ41_9BACT/2451-2536                 .................ALHHKDV......GDISLVWGN.........------..-EKAGLQKIIKKHP-..------........---.-EVLGNIQDIIDG.MHIVQ..TS.E...N--RIKLES....-D-SHFAVISRDWKG....E....AHT...PWLLTAYEKKEN-s..............
C8PBL3_9LACO/31-133                    kfneedvvmitktkkkr-------......----LVWLE.........----KG..NETKGLKHIIDGHEK..DFKNKF.......gVSK.ENIPSAIKDIFEN.GTEIS..SK.RknnGLEQVYLYK....--GEYIVI-------....-....---...-------------tgvgtngfivsvypg
R6AAX6_9BACT/5487-5585                 ................v-FHRKDI......GDIDMVWGD.........------..-DGGGLCHILNKHI-..NDKDFP........T-V.KDLVSRIEDIVNN.GKV--..DF.S...NGDKMVLKK....--DGYVVTIRRNVREk.giK...iADK...NWVLTAYNKDA--pa.............
A0A268TAT0_9HELI/1550-1632             .................AFYKEGL......GDIDLVWGD.........------..-EKMGLSHILSKHP-..------........---.-EVVDKIPEIIND.GK---..VD.R...GTNRIFLNT....DDSRIAIAL--DYKG....K....-DK...KWIITAYNKD---yl.............
A0A285M8H9_9RHIZ/344-434               ..............ald---HPEI......GDIDVIWGS.........-YDPKT..RKGSGLKKVFEKHP-..------........---.-EVVDNLPAIIRQ.AEVYT..Q-.-...SQNRIRLTD....GDHNIVVRLD--YDG....Q....AK-...TWLMTAFEKRKD-r..............
A0A3D8HL62_9HELI/594-687               .................AYERKDL......GDIDLVWGE.........-YNKET..QKGFGLSKILAKHP-..------........---.EITAEILTDIINN.GVIKR..QE.N...EAIQILRDN....----YKVVLKSNWKG....E...pTKN...KWIVTSYETK---gek............
I7GTU7_9HELI/427-521                   .................AFYRKEL......GDIDLVWGD.........------..-SNFGLKHILDKHGS..EF----........---.KDIAKELDEIIQN.GEVVK..NS.D...RATLQYTKE....NGEIFKVGLKGNWKG....E...pTQN...KWIITAYKDERE-m..............
H5VDY6_HELBI/1-82                      .................-------......---------.........------..-----MSKILEKHID..DFKGFEg......aNAL.EKLGNGIEAIIRN.GE-VL..KT.H...NGYNILYRG....----YKVGLNEGWNEggvkK....GSN...RWVVTAYDNSKS-l..............
A0A4R1KXL8_9PAST/905-1014              .................AMFRQGV......GWIDFIWGTvg.....riRPNGKS..KGAKGVSHIINKRMQ..ADNMSR........EQVeNFLTQELPSVINN.GDITE..HR.V...EEQSENIRI....EHNGNVVHLVK---E....Q....GKN...AWLLTAFESH---svn............
T1CYV3_9HELI/137-244                   .................AFYRDDLakstgtGEIDLVWGD.........------..-EKIGLKKIIEKHLS..DFADFKg......dTAQ.DKLANALGEIIAN.GK-IV..EN.A...GVNTIIYKI....GNDEFRVGLSKGFNG....A....GDN...QWIITAYQRSRQ-a..............
A0A268TAT0_9HELI/249-335               .................AFYKEGL......GDIDLVWGD.........------..-EKMGLSHILSKHP-..------........---.-EVVDKIPEIIND.GAVVV..RK.H...DATQINKDG....----YKVVLKSNLYG....E...pTDN...HWVITAYEDTR--gr.............
A0A1T0CD61_9GAMM/1534-1643             .................AMYRNDI......GWVDFVWGStg.....tiKANGKT..KGAMGISHIIEARMR..KDDMSY........DEVvEMLENKVVQAIAS.GSTSQ..VY.E...RGTARSIFI....EYSGYRVTLIK---R....E....GSN...SWLMNAFE-----ifdek..........
V8CKN9_9HELI/2129-2241                 .................AFYREEL......GEIDVVWGE.........ITDPEK..HKGYGLAHIVDKRKA..EFMQQSlseaqaeaKAI.DFTKNEIANIIEN.GKITN..KP.N...EATKIETPE....----YKLILKQNWKG....E...pLKN...KWLVTAYIKNEK-g..............
A0A3D8HK68_9HELI/74-168                .................AYERKDL......GDIDLVWGE.........-YNKET..QKGFGLSKILAKHP-..------........---.EITPELLDEIVSN.GK-LV..SE.N...NINTIIYEA....-DKTYRVGLSKGWDG....K....GNN...EWIITAYEVEKS-q..............
A0A268TAT0_9HELI/1025-1117             .................AFYKEGL......GDIDLVWGE.........VSNPSK..HTGYGLAHILDKHP-..------........---.DFDIGLIPEIVEK.GN-II..NR.H...NGYNIESEK....----YIVGINKGFDG....K....GDN...HWIVSAFDSKKP-t..............
A0A1T0CEJ0_9GAMM/558-667               .................AMYRNDI......GWIDFVWGDtg.....iiKTNGKT..KGAKGISHIIEARMR..KDKMSY........ADVvKMLTQDVMNIIAK.GSVIR..EI.T...RETTQRLTI....THANIIIHLIK---N....A....GSN...AWLLSGYEDNQM-v..............
A0A2M9P9Q3_9RHOB/3-89                  ...............ep-------......--ISLVWGE.........KGDGRR..GSGAGLAKIADRHP-..------........---.-EVLADLQGMLSAaTQVVS..RT.D...N--RIRLES....--DGYYFVVSRDFKG....A....PHR...PWLLTAFGKEKQ-g..............
A0A128EG14_9PROT/701-798               .................AFSKENL......GDIDLVWGE.........ITDAKT..HKGFGLAHIIDKHP-..------........---.EITPKIFNDIINK.GKLST..KW.D...GGYNIEFDG....----YIVGINKGWNKn.gkK...vANN...NWVVTAFDNTKD-r..............
A0A1I5JYX0_9RHIZ/352-442               ...............ai--SHPEI......GPIDVIWGD.........-YDPKS..QKGLGLKKIVEKHP-..------........---.-EVVNDLPGIVRS.ASIIT..KT.G...NR--IRLAS....DN--RMVVVRLDFDG....E....AK-...TWLMTAFEKKD--rh.............
A0A268TAT0_9HELI/1729-1820             .................AFYHPDI......GDITLVWGK.........-EGSAK..SDGFGLAKIVKFHP-..------........---.-EVVDKLDGIINN.GRFIL..DE.K...QRPNIVSDN....----SIVGLRNDWKG....E....KTP...YWVISSYSKKD--st.............
C8PFM4_9PROT/308-353                   .................AFYRKDL......GDVDIIWGE........aKQNAKG.gWDGYGLAKIEKKHPE..------........---.-------------.-----..--.-...---------....---------------....-....---...-------------isaqile........
A0A2W6MUX0_9HELI/1993-2090             .................AFYKEGL......GDIDLVWGD.........------..-SKMGLSHILERREE..DFIKQGfsk.eeaeAKV.LELIKEIPQILEN.STIYK..QT.P...QKIELITPR....--HTLVLGL------....-....---...-------------rddrkfiitelidkr
A0A377PTN5_9HELI/1482-1578             .................AFYRDEL......GDIDLVWGK.........VTNAEK..NKGYGLAHIIDKHP-..------........---.NLDLKLMADIVEK.GE-IK..ET.F...SGANIYYDD....----YILGINKGWGE....NgviyGDN...KWIVTAFNKGE--nh.............
A0A329ZK83_9HELI/21-112                .................AFYKEGL......GDIDLVWGN.........------..-EKMGLRHILERRSS..QWGE--........EKA.LKFVNDLDSIIQD.SKVKS..--.G...HNNTIELIT....PKHTIIVA-N-----....R....NDR...TFVISGFRDS---snkn...........
A0A329ZLR2_9HELI/21-131                .................AFYKEGL......GDIDLVWGKa.......eKDSKGQ..IKGYGLSKIIEKHYNngEFLAFG........EGE.KGLMNGLSEIIEK.GK-VI..SE.N...GVNTIWYKK....GNEYYKVGLSQGFEK....Q....GNN...NWIVTAYEAERE-k..............
A0A4R2PKI5_9SPHN/632-730               .........lhhealda-------......-PIDLPWGQ.........AGDPARdyRGGFGLAHILAKHP-..------........-EM.EAHLARLPEMIAD.MAVWR..HE.P...LRERLELED....--ARHRAVIALSWHG....K....-DA...RWLVTAFEKRT--pa.............
A0A2P2E1H6_9LEPT/12-81                 ...............iv--TRDDI......GGIDFPYGK.........----DG..KWGFGLANIIESRKN..EKNSKYn.....teGDF.LVLFQKLAKTLES.GEL--..--.-...---------....---------------....-....---...-------------hevkiiqig......
A0A1I5MUW3_9RHIZ/345-435               ...............al--DHPDL......GDIDVFWGD.........-YDLKT..DTGAGLKKIFEKHP-..------........---.-EVYDDLPEIIRS.LEVVS..KS.D...NRAILKSDK....----YKAVIRFDYDG....K....-EK...TWLLSAYEPT---ddw............
A0A3D8HK17_9HELI/38-144                .................AYEKDGL......-DLALVWGE.........-YNPQT..KQGIGLSKIYAKHLD..DFKAFVg......dTPE.EKLANGMSEIVEN.GR-LI..NV.N...GVESIVLNK....NGLSFRLGLSKGWNN....Q....GEN...RWIITAYKSIK--es.............
V2RHE7_9BACT/4-100                     .................AFHRDDI......GDIDLVWGN.........------..-KHYGLKHIEKQRN-..---KKG........QDF.NKLMEEITDVIEH.GKIID..DEwD...ENMKVIVDE....---TKKILIKLTWDD....E...kVENknrNWLFNGYF-----kye............
A0A329ZLH2_9HELI/1-60                  .............kyhp-------......---------.........------..---------------..------........---.-EVVSEIPQIIQE.GKILK..DD.K...GRLNIEYGN....----NIIELRNNWQG....E...eTEN...QWIITSYTKK---r..............
A0A2N5XTW7_9RHIZ/348-439               ..............ald---HPEF......GDIDVVWGE.........-YDPTT..QKGYGLKKIAEKHP-..------........---.-EVLDSLPDIIRN.SKVFS..LN.E...NRVRLLHGE....-NHVSVVGL--NWMG....E....-EK...VWLLTSFEDIK--gr.............
A0A268TAT0_9HELI/2324-2419             .................AFYKEGL......GDIDLVWGE.........VSNPSK..HTGYGLAHILDKHP-..------........---.DFDIGLIPEIVEK.GK-VV..EN.A...GVKSIKFNN....-GKSYRIGLSKGWLD....K....GDN...HWVITAYEDTR--lp.............
A0A1S5RFJ7_9CAUD/124-234               .................AAYREDL......GGIDFVWGT.........-PKTKE..SVGYGLAHVLERREQ..QALSDGlse.aeakEYA.LNIVKSIPEVLEK.GS--K..GT.D...SLGRVFVDY....GN--KRVGLNNTWNN....K...dLEN...HWVISSYEL----rdtt...........
F8KPC8_HELBC/840-950                   .................AFTRPDL......GDIDLVWGKq.......kGLKGGK..VVDIGLSRIHRKL-K..DFADFPgt...fanKKE.IKAANALTTIIQQ.GI-HL..EE.E...GLNTLWLKS....GPNYHGLSL--VLRN....A....QRR...AWIVTDHIKT---ptp............
F8KPC8_HELBC/664-758                   .................AFYRKDLge..ngGYIDLVWGE.........-SGTGK..SDGWGLSKIAKYHP-..------........---.-EVLDKLEELVQT.LPIVK..ET.P...NRYQLENAN....----YKASIRKDFEG....V....ARN...-WVLTAFEKKES-i..............
F8KPC8_HELBC/1146-1267                 .................AFYREDLge..sgGYIDLVWGAsatdlkglkDSNGKP..LKPYGLSKILEKHLD..DFKGFEg......aNAL.EKLGNGIEEIIRN.GE-VL..KT.H...NGYNILYRG....----YKVGLNEGWNEggvkK....GSN...RWVVTAYDNSKS-l..............
A0A0B6RLQ4_BURPL/46-154                .................AMYREGL......GWVDFVWGTegr...wppDARGRR..KGEKGISHVLEARPR..KDGMTAgq....alATL.HRMVRTIAEGAET.GR--F..SV.K...SVERIIVGR....--DGTEVHLIK---R....P....GSN...AWALTVFIE----qd.............
F2NT52_TRES6/26-130                    ...........iiknpv------L......GDVVFANGTl.......gNLEKKN..TGGFGIKHIIDGRYR..KDGLDE........KEI.SALLYLIKDTVET.----V..IP.D...DISKNRLNI....RKNSIFVGVSKQWLG....S....D-E...NWVITGFAEND--en.............
F8KQN1_HELBC/238-328                   .................AFFREDL......GYIDLVWGD.........------..-SKKGLAHILERRTQ..QYGEQQ........A--.LEFIHNLPRILQE.AKFWR..EI.E...DKIELVTPT....--D--MIVLGK----....R....DNN...KFVLTSFKDKRS-k..............
U5N8C9_9BURK/92-183                    .................ALYHPEV......GDIDLVWGR.........-AGTSR..SDGSGLSKLLKWHP-..------........---.-EVLNDLQGFISS.LTIRQ..RD.K...KVVQLWDGR....-SRRAAVKLTY---D....E....KQK...HWLLTAFEKD---gsg............
O34410_HELPY/822-926                   .................AFHKEGL......GDIDLVYGN.........------..-SKYGLEHIFNRRES..DAIDKGmsk.eeakKYA.LKIINNIPNIISN.GKLSK..DN.L...GRLSIEFEN....----QRVGLNDSWKG....E...tLNN...RWVITSYEIDK--sr.............
A0A2T5ITA8_9LACT/60-164                .................AMYRHDL......GWIDFVWGDvg....kppTASGKR..KGANGIAHILEARQR..KDGLTA........MQA.RALILKLVEVIAK.GKVIR..TN.I...VKGHENKVI....SYASYEATLVK----....D....NKN...EWLLSGWE-----v..............
A0A068YTK5_9BURK/79-185                .................AMFRNGL......GWVDFVWGSeg.....vtKASGKT..KGAMGLSHILEARQR..KDGMRE........AEV.THLLGRIVRTIAQ.GTEVR..RA.Q...AGNIERVVL....AHQGVEAVLTR---R....A....GSN...AWLLSGWK-----iws............
A0A0M2RGV4_9PROT/166-260               ...............kv--FREDL......GEISIDFGD.........------..-SKAGLQHIIKQRTE..KDGING........E--.AFVRERLPKILAK.GKLTR..FD.G...DFGERRATI....ETKNELVRLSL-MRY....D....KKE...TWLITAFEK----w..............
A0A3R6F3B8_9BACT/1088-1178             .................ALHHRDV......GDIDLVWGK.........-TGTGK..SNGFGLSKLAKYHP-..------........---.-EVLDNLQMLIDD.MEIVD..RN.D...NRINLESKT....----HKAAVRLEWDG....Y....KKN...-WLLTAFEKEKP-t..............
E7G4N4_9HELI/1-100                     .................-------......----MVWGE........iRDQSGK..LKGHGLAKIIEKHLD..DFKGFEg......nSAL.EKLGRGLEEIVEN.GKVVT..DQ.A...GIKTIILKK....DNQEFRVGLTQGWKH....E....GDN...YWIVTAYKR----ypke...........
A0A1S5RF23_9CAUD/1622-1726             .................AFYKEGL......GDIDLVWGN.........------..-SKYGLEHIFSRRES..DAIDKGlsk.eeakKYA.LEIINNIPNIISN.GKLSK..DN.L...GRLSIEFKN....----QKVGLNDSWKG....E...tLNN...RWVITSYEIDK--sr.............
A0A3D8HMP7_9HELI/189-284               .................AYERKEL......GDIDLVWGNv.......wKDEKGE..AQGFGLSKILAKHP-..------........---.EITPELLAEIIEK.GI-VE..NA.N...GRHSIVLDN....----FRVGLKSNWKG....T...pTKN...KWIITAYEVEN--pn.............
A0A268TBU3_9HELI/39-129                .................AFCRDDI......GDIDLVWGN.........------..-ENFGLCHILKQRTK..QFGEE-........-KA.LKFISHLEENIKH.GVMIK..AR.H...DRIGIITNK....----TTIILEQ----....C....QEN...HFVLTAYLDRKN-e..............
A0A4R2N7R4_9BURK/1698-1806             .................AMFRNGL......GWVDFVWGDeg.....riKPSGKT..KGAMGLSHILEARQR..KDGMSE........QEAiDALSQM-VNTIAS.GRELE..RS.A...YANTVALKL....ERDGYRVGLVK---R....P....GSN...AWVVTAFELNQM-q..............
T1D0F0_9HELI/36-128                    .................AYEKQGL......GDIDLVWGN.........------..-KDFGLEHIIAKHEG..DF----........---.KDLSQELSEIIAK.GE-VK..QD.N...NVLSIIYHK....DGETYRLGLSKGFRG....E....GEN...KWIITAYKVDKS-p..............
A0A1S5RGE7_9CAUD/1608-1719             .................AFYKEGL......GDIDLVWGT.........-PKTKE..SNGYGLAHILERRIS..NEMKKGlse.teakEYA.LNIVKSIPEVLEK.GT--K..GT.D...SLGRVFVDY....--DNKRVGLNNEWKK....E...kLEN...HWVISSYE-----lydtek.........
A0A2S5AK18_9PAST/664-774               .................AMYNHNL.....dGWVDFEWGDvg.....qiKPSGKT..KGAMGIAHIIESRIR..KDGMDY.......gQVS.QMLTHRVVETLAK.GQVSQ..IY.K...NGNVQSVFI....DYNGNRATLIK---R....Q....GSN...SWLMNAFEMK---ptd............
H5VDH4_HELBI/404-496                   .................AFYREDL......GYIDLVWGVnatdlkglrGANGKP..IKPYGLSKILEKHAS..DFESFK.......gADIqEKLAKGITKIIEK.GY-VP..EN.A...GIYTIRFKN....QDGSF----------....-....---...-------------re.............
A0A377PSD9_9HELI/1730-1831             .................AFYKEGL......GDIDLVWGN.........------..-KNIGLQKILEKHIN..DFKSFVg......dSAE.QKLINGIDEIVQN.GK-VV..SN.A...GVNTIIHNK....DNREYRVGLSKGFHS....N....GEN...NWVITAYKREN--ph.............
A0A5M6ICD2_9PROT/1789-1879             .................ALYHPEI......GDIDLVWGL.........-EGTGA..SNGYGLAKLARWHP-..------........---.-EVLDDLQSILSD.MR--V..EQ.R...GGNRVRLAS....--ERYRAVVRLQWDN....Q....AKN...-WLLTAFEKRR--sg.............
A0A3D8HKN7_9HELI/1445-1540             .................AYERKDL......GDIDLVWGE.........-YNKET..QKGFGLSKILAKHP-..------........---.EITAEILEEIVKN.GK-LL..DE.N...SIKTIIYNT....DNKIYRLGLSKGWKG....K....GEN...EWILTAYEVEKS-q..............
A0A1V3TVA0_9PAST/598-708               ................a-MFNHNL.....nGWVDFEWGDkg.....rrLPNGKT..KGAMGISHIIDKRMA..VDGMTE........QDVtRFLIEDVTDTIAK.GQVSR..EN.V...FGKTRTVEL....VHNGNEVRVTK---K....E....GNN...AWIVTGFKQNQP-m..............
A0A3N0V610_9PROT/2027-2125             .................AMYHNEL......GWIDFVWGD.........------..-NLKGVQHIIKQRTI..KDGLTV........DQVyQLLTERIVDAVAT.GNLVR..VR.E...FQVSRQVVL....EKNGYEAVLVR---N....K....GSN...GWVLSGWKVKT--pg.............
A0A1B8J8C8_9HELI/172-271               .................AFYKEDL......GDIDLVWGD.........------..-SAIGLKKIIEKHLD..DFKIWG........EGQ.EGLIKGINEIIES.GK-LI..DE.N...GIKTIWHKK....GDDYYLVGLSKGFNG....K....GKN...LWVITSYHKTNP-s..............
A0A3D8HJX2_9HELI/38-130                .................AFYKENL......GDIDLVWGN.........------..-EKFGLQHILEQRTK..QWGE--........QKA.LNFIDELPSIINQ.AKFFR..EY.E...GKVEFITDK....ET---LV-----FAK....R....NDR...HFVLTALID----krnkkr.........
A0A4U8U564_9HELI/985-1075              .................AMHKKGV......GDIDFIWGD.........------..-SEKGLQHILERRTQ..QYGE--........EKA.LKFVKDLPRMIDE.AVVFE..--.N...LKHKIILKT....PK--ATIVLGK----....R....ENN...QFVLSGFYDRKN-k..............
A0A084INL0_SALHC/1283-1395             .................AMYQPDL......GWVDFEYGDeg....grvTKKGNR..RGAKGISHILEARQR..KDGMSL.......dDAT.HFLTETIPNTIAR.GAVTR..RA.Sp.gQQRMQRATV....SWDGNEVNLVK---N....P....GSN...AWLLTGYKRT---pda............
A0A4U8UAP2_9HELI/22-123                .................AFYRKEL......GDIDLVWGN.........------..-DKIGLQKIVEKHLK..DFADFAg......nNPY.EKMSNAINEIIQN.GK-LL..TE.N...GVNTIWYKN....GDDYYLVGISKGFNK....K....GDN...NWVITSYKKTK--gr.............
A0A5C1E782_9RHOO/1174-1271             .................AMFRNGL......GWVDFVWGD.........------..-EKKGIAHIIARRIA..ADHMTR........SDVeRMLTESVVETIAR.GSELR..RN.E...FGGAVRLVL....THNQNEAILIR---K....P....GSN...AWMLTSFNV----kpg............
H5VCR0_HELBI/129-240                   .................AFYREDL......GHIDLVWGK........vKDKGSK..AEGWGLSKILEKHID..DFKGFEg......nTPL.EKLGDALDKIIRE.GQVLK..QE.G...GRMGVVCRI....GDKTFRLGLKKNWKG....N...pTHN...HWIITAYHDSEK-p..............
A0A0U1L3A3_9FIRM/2760-2863             .................AMYRPEV......GGVSFYWGT.........PGKGKK.fKSGSGVSHIIAKRN-..-FEG--........KNG.EDIARKLVEVIAH.GKVGE..VY.Gp.pKWERVNVSH....DGHTAVLSL---YKD....G....NLQ...TWLLTGWENNKE-g..............
A0A426K2U4_9FLAO/1202-1302             .................ALFREDI......GYIDIIWGE.........-NDPIT..NKGFGLKHIIEKHGN..EIKELG........F--.-KVENFIPIIVLF.GNYNQ..SK.K...NKNRIELTG....--DTFKIVISKKAFG....K....DK-...NFVLTAFD-----lrpsk..........
A0A3D8HKJ7_9HELI/263-362               ................g-FYKENL......GDIDLVWGN.........------..-ESIGLQKIVEKHLD..DFKIWG........EGQ.EGLIKGLNEIVES.GK-IE..TN.A...GVHTIILNK....DGAEYRVGLSKGWLG....K....GEN...LWVITAYERK---pha............
A0A329ZK91_9HELI/1-60                  .............kyhp-------......---------.........------..---------------..------........---.-EVVSEIPQIIQE.GKILK..DD.K...GRLNIEYGN....----SIIGLRNNWQG....E...eTEN...QWIVTSYTKK---r..............
A0A1B8J876_9HELI/106-202               .................AYERKEL......GDIDLVWGKv.......wRDEKGE..IQGYGLSKILDKHP-..------........---.EITPEILADIINN.GTLKR..QK.N...EAIQILKDD....----YKVVLKSNWKG....E...pTKN...KWIVTSYEAK---gek............
R7BYY7_9BURK/188-302                   .................AMFRQGL......GWVDFEYGSegs...eriKGNGMR..KGAVGILHIMEARYR..KDGYNE........KQI.GDLLDDVVYAIAD.GRETS..RQ.N..rEGENLKVTVenfrNGKTTRVALTK---T....P....SSD...AWVVTGFHV----dgl............
A0A1S5RG15_9CAUD/930-1037              .................AAYRDDL......GGIDFVWGK.........----DG..KDGYGLAHILEKREK..QYARLGlna.eqikERT.DELVKSIPEVIEN.GTLFK..DD.L...GRVSVGLND....----VKVGLTNQWFG....N...dLKN...HLIVTSYEKD---gkv............
A0A4U8U7Q6_9HELI/531-585               .................-------......---------.........------..---------------..------........---.------LAKIIQD.GE-VV..KT.H...NGYNITLGD....----YKVGLNIGWNEn.giK...iGEN...KWVVTAFDNSK--lq.............
V8CKN9_9HELI/1061-1162                 .................AFYREEL......GEIDVVWGD.........------..-EKIGLQKIVEKHLN..DFEKFDg......nNPF.EKLTNAINEIVES.GK-LI..SE.N...GVDTLWHKK....GDEYYLVGISKGFKG....Q....GEN...NWIITSYKKTKG-k..............
A0A4V6YSL7_9HELI/85-183                .................AFHRKEL......GDIDLVWGN.........------..-DKIGLQKIVEKHLK..DFAGNN........A-Y.EKMSNAMNEIIQN.GK-LL..TE.N...GVNTLWYKN....GNEYYLVGISKGFNK....K....GDN...NWVIASYKKTKG-k..............
A0A2W6MUX0_9HELI/1284-1383             .................AFYKEGL......GDIDLVWGD.........------..-SKMGLAHILEKHSK..DFKAFG........EGE.SGITKGISEIVEN.GK-VV..SD.K...GVNTIIYTQ....GENTYRIGISKGYFD....K....GEN...NWIITGYKVDKK-s..............
Q775D4_BPBPP/642-732                   ................a-LHHPDI......GDIDLVWGE.........-EGTRR..SDGYGLAKLAKWHP-..------........---.-EVLDDLQGILSA.MKVTS..RT.E...NRVNLESAD....----HRAGVRLTWDD....Q....AK-...HWLLTAFQKK---ggv............
A0A329ZL52_9HELI/290-352               .................AFHKEGL......GDIDLVWGK.........-AGSGR..SDEYGLAKIMKYHP-..------........---.-EVVSEIPQIIQE.GKILK..DD.K...GRLNIEY--....---------------....-....---...-------------g..............
A0A2M8RXZ8_9PAST/780-890               .................AMFRDGV......GWIDFIWGTeg.....tvKASGKT..KGGKGISHIIEARMR..KDNLSY.......dEAV.AFLTEEVPNIIAN.GRIER..DY.Ev.sGTRAIAI-I....RNDGSEVHLIK---K....G....NDN...AWLLTGFKPKE--sq.............
A0A329ZN80_9HELI/21-107                .................AFYKEGL......GDIDLVWGN.........------..-EKMGLRHILEKHSK..EF----........---.KDIASEINEIMEK.GI-ID..TH.I...ENNKIAIKT....NRHTLILGNKK----....-....-DN...KFIITAYRDSRN-k..............
A0A377PSD9_9HELI/2154-2245             .................AFYKEGL......GDIDLVWGD.........------..-SKMGLQHIIERRSQ..QW-GEE........KAL.RFIKEDLPQIVEN.SKLYK..QD.N...NKIELITDK....--DILI--LGR----....K....DNN...KFIVTSFKDRRS-k..............
A0A1S5RG62_9CAUD/953-1060              ................a-AFRDDL......GGIDFVWGK.........----DG..KDGYGLAHILEKREK..QYTRLGlnt.eqikERT.DELLKSIPEVIEN.GALFK..DD.L...GRVSVELNN....----IRVGLKNTWDN....N...nLNN...HFVVTSYERDEK-v..............
A0A268TWB6_9HELI/206-315               ................l-WHREDI......GDIDLPYGK.........VINPDK..HTGYGLAHILDKHEG..EFARFG........EGE.TGVINGLNKVIKE.GIVVDvdTQ.R...GLKDIWLKD....GEDYFKVRLRKSFDN....K....ETN...HWVATAFHHV---ndn............
F8KRJ3_HELBC/162-254                   .................AFYREDL......GYIDLVWGVnatdlkglrGANGKP..IKPYGLSKILEKHAS..DFESFK.......gADIqEKLAKGITKIIER.GY-VL..EN.A...GIYTIRFKN....QDGSF----------....-....---...-------------re.............
A0A2N3I809_9BACT/637-736               .................ALYRDDI......GYVSIVWGE.........--NNEK..NEGYGLKHIIEKHGA..DIEALG........F--.-AIEDFIPIVFAF.GTFNS..DK.S...IDGKIVLDS....--ESFRIIIQTNFFG....-....VKK...KWLLSAFDLKKK-m..............
H5VCV2_HELBI/565-677                   .................AFYREDLge..sgGYIDLVWGH........vKDKGSK..AEGWGLSKILEKHID..DFKGFEg......nTPL.EKLGNGINEIVQN.GEIVK..RQ.Gr.aEAYNIEYNG....----FVVGVNKGYNK....Q....GDN...YWVVTAFDKKKP-i..............
A0A4U8UAP2_9HELI/387-496               .................AFHRKEL......GDIDLVWGQ........vEGKGKE..AKGYGLAKIIEKHLNagDFKAFG........EGE.AGLINAMSEIIDK.GK-VI..TQ.N...GVDSIVLHK....NGEEYRIGISKGWDN....V....GEN...KWIITSYKNNK--yk.............
A0A268TAT0_9HELI/417-504               .................AFYKEGL......GDIDLVWGD.........------..-EKMGLSHILSKHP-..------........---.-EVVDKIPEIIQN.GE-AV..EN.A...GVKSIKFNN....-GKSYRIGLSKGWNN....K....GDN...HWVITAYEDTKS-p..............
A0A1S5RFE0_9CAUD/940-1047              ................a-AFRDDL......GGIDFVWGK.........----DG..KDGYGLAHILEKREK..QYTRLGlnt.eqikERT.DELLKSIPEVIEN.GALLK..DD.L...GRVRVELNN....----IRVGLKNTWDN....N...nLNN...HFVVTSYERDEK-v..............
H5VC03_HELBI/2-117                     .............gesg-------......GYIDLVWGAsatdlkglkGANGKP..LKPYGLSKILEKHAS..DFEGFKg......vNAL.EKLGNGIETIIKN.GNLVN..DQ.A...GVKTFILKD....NGREFRVGISQGWEH....E....GKN...YWIITAYENKKT-p..............
A0A1H2PQZ3_9BURK/701-792               ...............al--FHPEV......GDIDLVWGT.........-PPQGK..RPGTGLAKIVVKHP-..------........---.-EVLDDLQGLLSR.LKKDK..AN.S...GLNRVRLSD....ENGQAV--VSLDWKG....K....PK-...KWLLTAYEKE---ga.............
A0A4U8U7Q6_9HELI/503-537               .................AFHRKEL......GDIDLVWGE........vKGKGKN..AKGYGLAKIIQ----..------........---.-------------.-----..--.-...---------....---------------....-....---...-------------d..............
A0A268TZF4_9HELI/296-402               ................l-WHREDI......GDIDLPYGK.........VINPDK..HTGYGLAHILDKHEG..EFARFG........SGE.EGVINGLSEIIEK.GT-VI..NN.K...NVNTIWLKK....DDEYYLVGLSKGWKG....E....GDN...EWVVSSYKKTSE-i..............
A0A2W6MUX0_9HELI/1647-1751             .................AFYKEGL......GDIDLVWGD.........------..-SKMGLSHILERREE..DFIKQGfsk.eeaeAKA.REFIKNIPEIIEK.GEAII..KK.N...EAVKIETDN....----YKLVLKQNWKG....E...pTTN...KWLVTGYFKKEK-e..............
A0A3D8HKN7_9HELI/1800-1897             .................AFYKENL......GDIDLVWGE.........VTDSAK..HTGFGLAHAIDKHG-..------........---.EEVALKIPEIIEN.GK-VS..KT.H...NGYNIVWND....----YIVGVNKGFKDksgdY...iGTN...HWVVTAFEDTQ--gk.............
A0A5Q0BHF7_9GAMM/33-124                .................ALYHPEI......GDIDLVWGK.........TTDDAR..SKGTGIAKILRWHP-..------........---.-EVLRDLQGFISS.LH-VH..QR.H...-GKKIHLTG...nAGERAAVQVD--Y-D....Q....RNG...HWLLTAYIK----gya............
A0A268TAT0_9HELI/709-794               .................AFYKEGL......GDIDLVWGD.........------..-KRGGLSHILDKHG-..------........---.KDTALKIDDVIET.GQIFR..DK.H...NRLGILKDN....----QIVGIHEKYKG....D....-DR...QWIVTSYELK---dpk............
A0A1L3ZV74_9SPHN/540-630               ...............al--SHPEI......GPIDLVWGE.........-AGTNK..SDGFGLAKLTKFHP-..------........---.-EVVENLPEIIAG.M--TV..QS.E...SANRIRLES....PTHEAAVRL--DWDN....-....QQK...TWLLTAYEKGK--ra.............
#=GC seq_cons                          .................Aha+csL......GcIDLVWGc.............tt...puhGLu+Il-+H.t..t.................tplhpplscIIpp.Gp.hp..pp.p...sthplhhpp......t.htlsLpptats....p....spN...pWllTuacpp...t..............
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