GenomeNet

Database: Pfam
Entry: PF18834
LinkDB: PF18834
Original site: PF18834 
#=GF ID   LPD22
#=GF AC   PF18834.3
#=GF DE   Large polyvalent protein associated domain 22
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF SE   Iyer LM
#=GF GA   28.60 28.60;
#=GF TC   28.60 34.20;
#=GF NC   25.90 28.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   28559295
#=GF RT   Polyvalent Proteins, a Pervasive Theme in the Intergenomic
#=GF RT   Biological Conflicts of Bacteriophages and Conjugative Elements.
#=GF RA   Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;
#=GF RL   J Bacteriol. 2017; [Epub ahead of print]
#=GF DR   INTERPRO; IPR040738;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a predicted enzymatic alpha-helical domain with highly
#=GF CC   conserved aspartate residues [1]. The domain is found in
#=GF CC   polyvalent proteins of phage and prophage genes and is often the
#=GF CC   immediate neighbour of a lysozyme gene [1].
#=GF SQ   42
#=GS A0A1L3ZVI6_9SPHN/19-117  AC A0A1L3ZVI6.1
#=GS H8FP78_PHAMO/35-133      AC H8FP78.1
#=GS A0A1Y4GNW3_9BACT/40-145  AC A0A1Y4GNW3.1
#=GS A0A368WH57_9BURK/19-114  AC A0A368WH57.1
#=GS A0A0U1KXI5_9FIRM/19-119  AC A0A0U1KXI5.1
#=GS A0A1B7XA28_9DELT/57-156  AC A0A1B7XA28.1
#=GS A0A650ETA3_9CAUD/24-124  AC A0A650ETA3.1
#=GS A0A679K5N5_9CAUD/19-115  AC A0A679K5N5.1
#=GS A0A4Y5NY71_9CAUD/23-121  AC A0A4Y5NY71.1
#=GS A0A1G8AP24_9RHOO/26-123  AC A0A1G8AP24.1
#=GS A0A4S4AWA1_9RHOO/40-136  AC A0A4S4AWA1.1
#=GS A0A2S8BAM0_9SPHN/31-127  AC A0A2S8BAM0.1
#=GS A0A1H4HT81_9BURK/50-148  AC A0A1H4HT81.1
#=GS A0A073ITB4_9BACT/38-142  AC A0A073ITB4.1
#=GS A0A1B7XAY0_9DELT/33-132  AC A0A1B7XAY0.1
#=GS T0H2D0_9SPHN/34-130      AC T0H2D0.1
#=GS A0A4P2VSA8_9CAUD/38-133  AC A0A4P2VSA8.1
#=GS K7ZRM7_9CAUD/19-115      AC K7ZRM7.1
#=GS A0A381E9H3_9GAMM/11-106  AC A0A381E9H3.1
#=GS A0A3A5LCD5_9RHIZ/19-123  AC A0A3A5LCD5.1
#=GS N6X718_9ALTE/42-139      AC N6X718.1
#=GS Q6LJT0_PHOPR/42-141      AC Q6LJT0.1
#=GS A0A196MP94_9SPHN/33-129  AC A0A196MP94.1
#=GS Q775D4_BPBPP/40-139      AC Q775D4.1
#=GS A0A377R1N8_9NEIS/18-113  AC A0A377R1N8.1
#=GS A0A679KGH5_9CAUD/19-115  AC A0A679KGH5.1
#=GS A0A6I5YUW6_9SPHN/27-122  AC A0A6I5YUW6.1
#=GS V7FHU5_9RHIZ/19-123      AC V7FHU5.1
#=GS A0A1B7X8P5_9DELT/31-130  AC A0A1B7X8P5.1
#=GS A0A5C5UCP2_9GAMM/19-115  AC A0A5C5UCP2.1
#=GS A0A0A0EVV4_9GAMM/21-116  AC A0A0A0EVV4.1
#=GS A0A1C9VHP3_9BURK/35-132  AC A0A1C9VHP3.1
#=GS C1D7V1_LARHH/17-116      AC C1D7V1.1
#=GS A0A502C2R0_9SPHN/20-118  AC A0A502C2R0.1
#=GS A0A0R3Q2Z1_9BILA/1-93    AC A0A0R3Q2Z1.1
#=GS K4NZ44_9CAUD/42-139      AC K4NZ44.1
#=GS A0A0M4CXX7_SPHS1/38-136  AC A0A0M4CXX7.1
#=GS A0A243PEU0_9SPHN/28-125  AC A0A243PEU0.1
#=GS A0A106BIY4_THIDE/34-130  AC A0A106BIY4.1
#=GS A0A1N6KP96_9BURK/42-140  AC A0A1N6KP96.1
#=GS B6WT73_9DELT/17-111      AC B6WT73.1
#=GS A0A0B8ZJZ7_9SPHN/48-146  AC A0A0B8ZJZ7.1
A0A1L3ZVI6_9SPHN/19-117             .....d-ARAASMAV-VGINPDSDADLQRKAQSLG.......IPIESARRDP....QGFEQRVr...eTNTDWD..EMA..RTRP..ITTR..LM.GSASKAAIAQD..DVAN..MAELERKFGSIRAQRQ--pe.......
H8FP78_PHAMO/35-133                 ..arlg----SNLIAAADTNPDAHAKAMEIGRQIG.......APADAIAANL....GEGERMA.....KLQKMR..EAL..GSAP..KLAE..FLtSDPDMAKLSSD..DFSA..LTRLEGSMTAAASFG---rgv......
A0A1Y4GNW3_9BACT/40-145             ..dele----RSYERYVTENPDEAAARAWNAERVG.......VPLWVQERSDkyanEAKKRLAll.ekGTPDWK..KLA..DASP..VTAS..FM.TGDGVMASAHD..DVQG..LADIEDVTHSLSYLRL--ny.......
A0A368WH57_9BURK/19-114             .rgvkt-----ALSEAYGTNPNIEAELQRVSKTTG.......VPLSTARNMP....NEAKRNAy...vNGINAF..ELA..KNYP..IFAR..FI.TNENNARVAHD..DVDN..LTALEKAVREL-------pde......
A0A0U1KXI5_9FIRM/19-119             ....np--LGQVMQVAKNLPQDQAAKILKYSLASG.......DAPILVANNL....HAYETDI....vDQIDWD..NVL..QQSP..KTYE..FL.NNPLHMAAVRDqqNVAT..LSNLENSWLSWHDLKEG-g........
A0A1B7XA28_9DELT/57-156             ......RSAAPMLEYAVTRNPDTVADAQKIAKRTG.......MDADFVEQNY....DQLSAQD.....RAERQQ..RLM..ETMD..AGGTmyFM.RDPVNAGMAHD..DLEN..LIRIEQESNPFRALGKT-a........
A0A650ETA3_9CAUD/24-124             ..tqlk----ANVSEAVKIDPVQHSEITNLSKESG.......VPEFAVKSNP....KKVKQQLd...lSKVDLD..GMV..QRSP..NTSK..FLaADMNNAVIAQE..DVFGglLEGIEETFRGLGR-----sig......
A0A679K5N5_9CAUD/19-115             .....r-ARAAGVTA-PQVDPDAMGRAMRLADQRG.......LPPGVVADNL....PEYDQQQ.....QQDALG..DAA..SASP..VLAR..WL.GDPNHSALSKD..DTGV..LAGLGRQFNSGL------lsaket...
A0A4Y5NY71_9CAUD/23-121             ..klkd-----SLLYGVQQQPDMQARMRRYARDLN.......VPLPAALEDH....QYVGQVG.....AVQDLDpnGMV..LGSP..KTAT..WL.AEPDNAAVAHD..DVPI..LQQVENGVRHLGQLGKA-s........
A0A1G8AP24_9RHOO/26-123             kalreq------YRA-TSITPDDAAKVIDISARTG.......IPKPVVVRNQ....SEAAKLA.....AEPDWD..GLQ..VTAP..VTVR..ELaANTKLFDLAHD..DTDN..LSELERTMNRRSEGQ---igg......
A0A4S4AWA1_9RHOO/40-136             ...rav---QSTLDRALKIAPQRAATVQQLAERTG.......LPADLVERNF....EDIERRD.....RVREVQ..RLA..ASSP..ILAR..QL.FDPQFAALAHQ..DVEQ..LGIAERIARQL-------aggale...
A0A2S8BAM0_9SPHN/31-127             ...ves----TAISLLNAPPPDTVADAARLAQRFG.......INAMQVAGNL....EEFKRRQ.....RIEDLT..STA..LSIS..GFGS..WA.QNPQNAAIAAD..DTEN..VGVLGSIWQGIKNVGS--sa.......
A0A1H4HT81_9BURK/50-148             .....q-TAQSNIALAVGANPDYEAEMQRLAQQTG.......TPVDSVKAFP....DVVKQKAt...vNSIDFQ..NLA..KQFP..TTAA..FY.QSQNNAKIAHD..DVGG..LQSVEQATTNLGPA----snv......
A0A073ITB4_9BACT/38-142             ...kle---EVYTKY-AAEDPEAHARRVWTAEAVG.......VPQWIQERDEm.yaKEAERRLalltkGMPDWR..GLS..EKYP..LTAR..FF.EDEDVMASAND..DVEA..LAAKEGEARRAGAVAKA-l........
A0A1B7XAY0_9DELT/33-132             ......RSAAPMLEYAVTRNPDTVADAQKIAKRTG.......MDADFVEQNY....DQLSAQD.....RAERQQ..RLM..ETMD..AGGTmyFM.RDPVNAGMAHD..DLEN..LIRIEQESNPFRALGKT-a........
T0H2D0_9SPHN/34-130                 ..rdde----LAYRI-KVARPDEEARARALAEPRG.......LAPSAVASNL....PAFEAEA.....RAAKAK..NVM..SQYP..AIGR..WS.AKPGNAAIAAD..DYDN..LSLFGKAFYGLKNFGKT-l........
A0A4P2VSA8_9CAUD/38-133             ..ndfm----STLEVVGEVNPDQFAKATAVSKYSG.......IPAEVLHKQQ....DQMEKLL.....KNNRYA..AVF..DSFP..KTAA..AL.SNGQTAALAQD..DIDN..LTRIEYA-----------kqitkfenq
K7ZRM7_9CAUD/19-115                 ......RARAAGITA-PQVEPDAMGRAMRLADQRG.......LPPGVVADNL....PEYDQQQ.....QLDALG..DAA..SASP..ALAR..WL.GDPNHTALSKD..DTGV..LAGLGRQFNSGL------lsaket...
A0A381E9H3_9GAMM/11-106             ....aa--RRLRLLDALHLNPDKRAEDRTIGMATG.......TPIGLVDDN-....--TRRQY.....RVNQLD..AQM..QGLA..VLPA..AVrKSETFATLAQD..DLET..LASLEKVTKARQRRAN--ai.......
A0A3A5LCD5_9RHIZ/19-123             .....v-GAAQVVLGSVNEKPDQVAGDVNLANEFGkatgnpvPPLPMVREYR....NVFQQKI.....EEQKNK..TIL..STSP..RLTD..WL.RSPDNAALARD..DLQN..LSWFEGFGRGATNTLSR-s........
N6X718_9ALTE/42-139                 ...vla----RSVNQAVTEQPDDLAYIRRLSEDTG.......LSPYIVRENR....DDIERRV.....KQREMG..AQI..EGFS..QPGK.eWL.SRPDNLGVAQD..DLPA..LRALDDAIANRDWYAQD-s........
Q6LJT0_PHOPR/42-141                 .....f-QLSTSMKYGREADPERAGRVFRQQLKTG.......LPSELIERNL....DDIEKQS.....AEKDFD..PVAfrNKSP..LLSG..WL.QKPENAKVSHD..DLEN..LSTMEWLFRAPVEAYQD-g........
A0A196MP94_9SPHN/33-129             .....r-DEEMAFRI-KVAKPDEAARAGAIAKARG.......LPAAVVESNL....PAFEMEA.....RAARAK..AAA..QDYP..AIGR..WS.AKGNNAAVAAD..DYDN..LSLLGKAFYGLKNVGKT-v........
Q775D4_BPBPP/40-139                 .....q-AARAGFVLASDTDPDAYAEAQRVARRAN.......LPIETVLNQP....KEAKRQDt...iGAIDFD..TLG..KTSP..ATAA..LL.ADVEKAKIAHD..NVDN..MTGIESVLSSLGTAVKY-l........
A0A377R1N8_9NEIS/18-113             rslian------AEAGAGVSPDEAAKRRQTAQRLG.......VPVQAVNDAP....VSAVLQE.....QFDKVW..RDT..QGLG..TLRG..KM.TQPDFYNLAKD..DTPQ..LGTIGELANSAA------rgff.....
A0A679KGH5_9CAUD/19-115             .....r-ARAAGVTA-PQVDPDAMGRAMRLADQRG.......LPPGVVADNL....PEYDQQQ.....QQDALG..DAA..SASP..VLAR..WL.GDPNHSALSKD..DTGV..LAGLGRQFNSGL------lsaket...
A0A6I5YUW6_9SPHN/27-122             ..niqr------TEMARLPDPDRAARTSAVARQYG.......VTPTQADADL....DDWEKRR.....RIDGAL..ATH..DAYP..AIGR..WA.GQGNNAAIAAD..DYDN..LGLFGKAFYTLKG-----vgssl....
V7FHU5_9RHIZ/19-123                 .....v-GAAQVVLGSVNEKPDEIAGDLNLANEFGkatgnpvPPLPMVREYR....NVFQQKI.....EEQKNK..TIL..SSKP..RLTE..WL.RSPDNAALARD..DLQN..LSWFEGFGRGVTNTLSR-s........
A0A1B7X8P5_9DELT/31-130             ......RSAAPMLEYAVTRNPDTVADAQKIAKRTG.......MDADFVEQNY....DQLSAQD.....RAERQQ..RLM..ETMD..AGGTmyFM.RDPVNAGMAHD..DLEN..LIRIEQESNPFRALGKT-a........
A0A5C5UCP2_9GAMM/19-115             .....q-QTATVIAATEGQTSQATAEVIDLSQRTG.......APVGAVRADP....EGARQHV.....ERQQLD..TLA..AASP..TVSA..WVtGDPDRYALARD..DVPL..LGRFAAP-----------lpdwrqlls
A0A0A0EVV4_9GAMM/21-116             .....r-AREAAITS-PAIAPDDMAKAQRLGAAHG.......IGPQAVADDL....KHYDELD.....QVDRME..RFA..TSTP..GASR..WL.-TPERAALVRD..DVDT..LERLGRALPSKGATMRA-t........
A0A1C9VHP3_9BURK/35-132             .....r-AVRGSLTATAQTTPERAAQLNYLAQVSG.......MPRAVVETDE....GSAKAVA.....QLREIW..DAS..ADSP..VLRA..KL.ANPQFTELAKD..DVGV..LSQIERGVQATTRYIM--ga.......
C1D7V1_LARHH/17-116                 ....dq--LAGSLRDALQVNPDDYAKTVRLAKAAG.......VEVEAVPLYA....DVAQEAQy...lEGIGFR..SLW..KDSP..KTAE..FL.SDARNARLAHD..DVAN..LSVLEKLARSAGAGLT--aa.......
A0A502C2R0_9SPHN/20-118             ...dpt---RQSLVQTSHLNPDREVENRAIADQLG.......LPGQFIRDNE....AEARRIK.....AQRDAA..ATA..ASIRgtKTAS..FL.ADTSKAAIAHD..DVGV..LAKIGHWF----------genwancrl
A0A0R3Q2Z1_9BILA/1-93               ..msvg----------LGANPDMEAELRKVARRTG.......VPVDTARAYP....EELKRQAa...mGQMDFD..SLA..QQFP..RTAG..FL.SGTENAKVAHD..DVEN..MGLIETMINSFQR-----gipa.....
K4NZ44_9CAUD/42-139                 ....qd--FVHSMETVSNISPDAYAKATAVSRYSG.......VPAKVLHDNA....DRMNQLL.....RGNQYA..GIY..TNYR..KTAN..AL.RDGNLAAVSQD..DLDQ..LVRIEGAASDTRFNQQS-t........
A0A0M4CXX7_SPHS1/38-136             ......RDRQTRLDLLLSASPDTVGRATTIAKEIG.......VPPMHVEDRL....AEAEKGR.....HVRRFM..SVA..ERYP..AIGK..WAvTQPRGAAAASD..DWDS..LSLLGKTWRSTREVATG-i........
A0A243PEU0_9SPHN/28-125             .....a-AARRSIIMHNAASPDAAARANVLSRENG.......LPPTIVEQHL....PAFEIAR.....RSERAN..ALM..AKHP..AIGR..WS.SDPRNIAAAAD..DYDN..LGKLGAAFASRIARDK--rd.......
A0A106BIY4_THIDE/34-130             ...avr----AGATLALDSNPDEIARQKRIAQSLG.......VPLAAVEADP....EFATREQ.....RVRSIE..QAT..ANSP..ALRQ..KF.SDADFAKLAAD..NVDN..LSGIEQLLRSAKRGFT--ag.......
A0A1N6KP96_9BURK/42-140             ....qa--AQGVAVANSEQSADAAGRAAGIAKQIG.......APQAAVETDL....PRYEAQA.....KAQNNA..QIL..SQSP..RLAD..WVaNNPDSARVAQD..DFDG..MSQLEGLTSAQSAQAL--ta.......
B6WT73_9DELT/17-111                 ....ir--AALEVADADGVTAQRVASARATALQLG.......LPDSVVEADL....QYAQREA.....QARRIE..---..QNSP..FALW..AA.RSKERAALARD..DTDG..LAGVFSTAKAFGEIRQY-e........
A0A0B8ZJZ7_9SPHN/48-146             ....rg--RMLGATLRASPAPDQAAQANRIARARG.......LPAAVVDPKL....QVLQIAD.....QATNFL..NMT..RLFP..HIGS..WAeANPRDAAAAAD..DTKA..LGMLGHAFSERDLSR---gys......
#=GC seq_cons                       .....t...ttslphssshsPDphAcspplAcptG.......lPsssVcssh....sphcppt.....ptpchp..shh..ps.P..thup..ah.sssspAulApD..Dlss..LutlEpthpuhtthh...s........
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