GenomeNet

Database: Pfam
Entry: PGP_phosphatase
LinkDB: PGP_phosphatase
Original site: PGP_phosphatase 
#=GF ID   PGP_phosphatase
#=GF AC   PF09419.10
#=GF DE   Mitochondrial PGP phosphatase
#=GF PI   DUF2010;
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Wood V;0000-0001-6330-7526
#=GF SE   Pfam-B_22310 (release 21.0)
#=GF GA   20.40 20.40;
#=GF TC   20.40 20.40;
#=GF NC   20.30 20.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   20485265
#=GF RT   A mitochondrial phosphatase required for cardiolipin
#=GF RT   biosynthesis: the PGP phosphatase Gep4.
#=GF RA   Osman C, Haag M, Wieland FT, Brugger B, Langer T;
#=GF RL   EMBO J. 2010;29:1976-1987
#=GF DR   INTERPRO; IPR027706;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a family of proteins that acts as a mitochondrial
#=GF CC   phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique
#=GF CC   dimeric phosphoglycerolipid predominantly present in
#=GF CC   mitochondrial membranes. The inverted phosphatase motif includes
#=GF CC   the highly conserved DKD triad [1].
#=GF SQ   1039
#=GS A0A084RNN2_STACH/5-180      AC A0A084RNN2.1
#=GS A0A0M8MTE6_9BASI/3-168      AC A0A0M8MTE6.1
#=GS E7KDF1_YEASA/3-166          AC E7KDF1.1
#=GS A0A1S3VL58_VIGRR/146-301    AC A0A1S3VL58.1
#=GS C1HBT3_PARBA/9-229          AC C1HBT3.1
#=GS Q24UV8_DESHY/2-141          AC Q24UV8.1
#=GS A0A0K8J997_9FIRM/2-82       AC A0A0K8J997.1
#=GS I1HSG5_BRADI/59-221         AC I1HSG5.1
#=GS A0A1U8AX89_NELNU/144-316    AC A0A1U8AX89.1
#=GS A0A0L9VEE5_PHAAN/192-352    AC A0A0L9VEE5.1
#=GS A0A074VFC8_9PEZI/3-179      AC A0A074VFC8.1
#=GS W9A7R2_9BACI/2-141          AC W9A7R2.1
#=GS A0A194XNW6_9HELO/8-187      AC A0A194XNW6.1
#=GS F6DUE4_DESRL/11-151         AC F6DUE4.1
#=GS A7F211_SCLS1/72-246         AC A7F211.1
#=GS A0A1E3QWB3_9ASCO/6-173      AC A0A1E3QWB3.1
#=GS A0A1H3FIX4_9FIRM/1-141      AC A0A1H3FIX4.1
#=GS A0A1X2IVL0_9FUNG/7-167      AC A0A1X2IVL0.1
#=GS A0A117S989_9FIRM/3-141      AC A0A117S989.1
#=GS A0A1B7TCL8_9ASCO/1-164      AC A0A1B7TCL8.1
#=GS A0A031ILA6_9BACL/2-82       AC A0A031ILA6.1
#=GS A0A0U1QQZ7_9BACL/1-141      AC A0A0U1QQZ7.1
#=GS A0A0E0FUE3_ORYNI/59-214     AC A0A0E0FUE3.1
#=GS A0A0L0MJ13_9MOLU/1-142      AC A0A0L0MJ13.1
#=GS A0A1S4A9P9_TOBAC/130-268    AC A0A1S4A9P9.1
#=GS A0A166ACF6_DAUCA/121-173    AC A0A166ACF6.1
#=GS A0A0A1MK26_9FUNG/81-151     AC A0A0A1MK26.1
#=GS A0A2C5XUI2_9HYPO/1-154      AC A0A2C5XUI2.1
#=GS A0A075LL25_9BACI/2-141      AC A0A075LL25.1
#=GS Q6YQS2_ONYPE/2-147          AC Q6YQS2.1
#=GS V7CMI9_PHAVU/146-307        AC V7CMI9.1
#=GS A0A265NCZ0_9BACI/1-141      AC A0A265NCZ0.1
#=GS A0A2K3DU55_CHLRE/60-219     AC A0A2K3DU55.1
#=GS A0A1U7MK96_9FIRM/2-139      AC A0A1U7MK96.1
#=GS G8JN97_ERECY/7-170          AC G8JN97.1
#=GS A0A0A2U329_9FIRM/2-81       AC A0A0A2U329.1
#=GS A0A0A8E689_9GAMM/7-163      AC A0A0A8E689.1
#=GS J4GW90_9APHY/5-170          AC J4GW90.1
#=GS A0A1J5GI95_9BACT/2-141      AC A0A1J5GI95.1
#=GS R7LME0_9CLOT/1-139          AC R7LME0.1
#=GS A0A0F7ZN54_9HYPO/6-181      AC A0A0F7ZN54.1
#=GS A0A0W0GDD8_9AGAR/5-168      AC A0A0W0GDD8.1
#=GS A0A0H2S6X8_9HOMO/5-171      AC A0A0H2S6X8.1
#=GS C1G4Y4_PARBD/9-229          AC C1G4Y4.1
#=GS A0A1Y1WMT6_9FUNG/53-127     AC A0A1Y1WMT6.1
#=GS A0A0D7B4A0_9AGAR/6-169      AC A0A0D7B4A0.1
#=GS K1VRW5_TRIAC/7-142          AC K1VRW5.1
#=GS A0A1E5R272_9ASCO/3-171      AC A0A1E5R272.1
#=GS A0A074LWD7_9BACL/1-138      AC A0A074LWD7.1
#=GS A0A2G9GSS6_9LAMI/125-286    AC A0A2G9GSS6.1
#=GS A0A015JZV5_9GLOM/6-168      AC A0A015JZV5.1
#=GS A0A1J8PL31_9HOMO/5-72       AC A0A1J8PL31.1
#=GS A0A1E5R8W4_9ASCO/4-182      AC A0A1E5R8W4.1
#=GS W7IG98_9PEZI/6-176          AC W7IG98.1
#=GS A0A1X7IAL5_9BACL/32-177     AC A0A1X7IAL5.1
#=GS A0A1E3BQE0_9EURO/6-200      AC A0A1E3BQE0.1
#=GS A0A098VTI0_9MICR/13-176     AC A0A098VTI0.1
#=GS B5YLW3_THAPS/1-115          AC B5YLW3.1
#=GS A0A0F9XF40_TRIHA/5-180      AC A0A0F9XF40.1
#=GS W9XEF2_9EURO/9-190          AC W9XEF2.1
#=GS A0A135LG93_PENPA/9-204      AC A0A135LG93.1
#=GS A0A1S4A9U8_TOBAC/130-260    AC A0A1S4A9U8.1
#=GS V2XDK8_MONRO/5-168          AC V2XDK8.1
#=GS A0A161X2V7_9PEZI/56-231     AC A0A161X2V7.1
#=GS E4ZYV0_LEPMJ/52-231         AC E4ZYV0.1
#=GS A0A1L9VYT3_ASPGL/6-200      AC A0A1L9VYT3.1
#=GS A0A1G4IVB5_9SACH/3-166      AC A0A1G4IVB5.1
#=GS A0A094CEI8_9PEZI/9-186      AC A0A094CEI8.1
#=GS A0A137PIM6_CONC2/7-165      AC A0A137PIM6.1
#=GS A0A1Q8Q7U8_9BACI/1-139      AC A0A1Q8Q7U8.1
#=GS A0A251SNM8_HELAN/131-292    AC A0A251SNM8.1
#=GS A0A087SRK5_AUXPR/12-170     AC A0A087SRK5.1
#=GS A0A177UV12_9BASI/5-147      AC A0A177UV12.1
#=GS W8GFV2_9MOLU/19-167         AC W8GFV2.1
#=GS D5GHB7_TUBMM/6-172          AC D5GHB7.1
#=GS A0A0L0SDZ8_ALLMA/7-167      AC A0A0L0SDZ8.1
#=GS A0A067KQ13_JATCU/135-296    AC A0A067KQ13.1
#=GS B6QI78_TALMQ/9-221          AC B6QI78.1
#=GS A0A1B3SKT7_9MOLU/7-149      AC A0A1B3SKT7.1
#=GS J6EKF2_SACK1/3-166          AC J6EKF2.1
#=GS K4CGD1_SOLLC/130-291        AC K4CGD1.1
#=GS A0A0L9VE80_PHAAN/146-307    AC A0A0L9VE80.1
#=GS A0A0A2VDL3_BEABA/5-104      AC A0A0A2VDL3.1
#=GS A0A2A9PH80_9HYPO/5-180      AC A0A2A9PH80.1
#=GS U6E1Q6_9MOLU/2-147          AC U6E1Q6.1
#=GS R9P4M7_PSEHS/4-160          AC R9P4M7.1
#=GS A0A099P588_PICKU/6-171      AC A0A099P588.1
#=GS A0A074RMJ8_9HOMO/5-166      AC A0A074RMJ8.1
#=GS A0A1G9CM51_9CLOT/1-138      AC A0A1G9CM51.1
#=GS A0A2B7Y7Y0_9EURO/9-229      AC A0A2B7Y7Y0.1
#=GS D0N062_PHYIT/6-167          AC D0N062.1
#=GS A0A2H3J0L8_WOLCO/5-167      AC A0A2H3J0L8.1
#=GS R8NX37_BACCE/1-139          AC R8NX37.1
#=GS A0A1B7NYF6_9EURO/9-229      AC A0A1B7NYF6.1
#=GS A0A0N0NI87_9EURO/86-163     AC A0A0N0NI87.1
#=GS S7ZEB5_PENO1/9-203          AC S7ZEB5.1
#=GS A0A088TQ05_9BACT/1-146      AC A0A088TQ05.1
#=GS A0A0C4DVK1_MAGP6/5-181      AC A0A0C4DVK1.1
#=GS A0A0L0SDM2_ALLMA/5-158      AC A0A0L0SDM2.1
#=GS A0A017SUA4_9EURO/6-203      AC A0A017SUA4.1
#=GS A0A1E3KXC8_9BACL/2-138      AC A0A1E3KXC8.1
#=GS A0A094JS00_9BACL/1-139      AC A0A094JS00.1
#=GS A0A0W7VT20_9HYPO/5-180      AC A0A0W7VT20.1
#=GS R5MV58_9MOLU/1-138          AC R5MV58.1
#=GS A0A1S3VEW0_VIGRR/192-352    AC A0A1S3VEW0.1
#=GS A0A2G2WS67_CAPBA/82-153     AC A0A2G2WS67.1
#=GS A0A059LS67_9CHLO/14-173     AC A0A059LS67.1
#=GS A0A140DY83_9FIRM/5-146      AC A0A140DY83.1
#=GS A0A1G8JWK3_9BACI/3-140      AC A0A1G8JWK3.1
#=GS A0A1S3BN52_CUCME/142-303    AC A0A1S3BN52.1
#=GS A0A1Z5SMJ1_HORWE/3-179      AC A0A1Z5SMJ1.1
#=GS A0A1B9IDX8_9TREE/8-143      AC A0A1B9IDX8.1
#=GS A0A1E3NZR8_WICAO/3-171      AC A0A1E3NZR8.1
#=GS A0A074WPQ9_9PEZI/3-179      AC A0A074WPQ9.1
#=GS A0A1G3WTY4_9BACT/1-141      AC A0A1G3WTY4.1
#=GS K3XKU8_SETIT/64-226         AC K3XKU8.1
#=GS F2I5U8_AERUA/2-141          AC F2I5U8.1
#=GS B0D8J8_LACBS/5-171          AC B0D8J8.1
#=GS A0A2G9GJI7_9LAMI/69-193     AC A0A2G9GJI7.1
#=GS A0A1T2XEQ8_9BACL/2-138      AC A0A1T2XEQ8.1
#=GS A0A0U1KVC5_9FIRM/2-140      AC A0A0U1KVC5.1
#=GS V7BJA1_PHAVU/146-307        AC V7BJA1.1
#=GS M4BR00_HYAAE/1-139          AC M4BR00.1
#=GS G2TNH6_BACCO/2-141          AC G2TNH6.1
#=GS R5V4E4_9FIRM/1-139          AC R5V4E4.1
#=GS A0A1E5RZ45_HANUV/4-182      AC A0A1E5RZ45.1
#=GS C9RC25_AMMDK/2-138          AC C9RC25.1
#=GS A0A1F7ADU1_9BACT/5-129      AC A0A1F7ADU1.1
#=GS A0A259UKV0_9FIRM/2-140      AC A0A259UKV0.1
#=GS A0A0J7BET2_COCIT/8-213      AC A0A0J7BET2.1
#=GS A0A0C3Q6P9_9HOMO/5-135      AC A0A0C3Q6P9.1
#=GS R6H7V3_9FIRM/2-139          AC R6H7V3.1
#=GS A0A0N0NI87_9EURO/12-91      AC A0A0N0NI87.1
#=GS A0A0J0XLB0_9TREE/6-136      AC A0A0J0XLB0.1
#=GS H1BKF0_9FIRM/2-141          AC H1BKF0.1
#=GS A3LV06_PICST/4-171          AC A3LV06.1
#=GS A0A1V2MDP7_9FIRM/2-140      AC A0A1V2MDP7.1
#=GS A0A1H9YR76_9CLOT/1-138      AC A0A1H9YR76.1
#=GS A0A0C3NTS1_PHLGI/5-173      AC A0A0C3NTS1.1
#=GS A3DDR0_CLOTH/2-139          AC A3DDR0.1
#=GS A0A1Y2EIC0_9PEZI/6-179      AC A0A1Y2EIC0.1
#=GS I1JWJ8_SOYBN/147-308        AC I1JWJ8.1
#=GS H6BNM6_EXODN/9-190          AC H6BNM6.1
#=GS A0A2H3EQZ2_9HELO/5-178      AC A0A2H3EQZ2.1
#=GS A0A1V6P8V7_9EURO/9-206      AC A0A1V6P8V7.1
#=GS A0A2G2YT66_CAPAN/146-307    AC A0A2G2YT66.1
#=GS D8QA39_SCHCM/5-173          AC D8QA39.1
#=GS A0A1Y2AAK8_9PLEO/3-180      AC A0A1Y2AAK8.1
#=GS E7LVD9_YEASV/3-166          AC E7LVD9.1
#=GS A0A179UW02_BLAGS/9-229      AC A0A179UW02.1
#=GS A0A1E7FEZ9_9STRA/1-127      AC A0A1E7FEZ9.1
#=GS L0PFI1_PNEJ8/3-181          AC L0PFI1.1
#=GS Q9LXR9_ARATH/139-300        AC Q9LXR9.1
#=GS A0A1B8EI73_9PEZI/9-186      AC A0A1B8EI73.1
#=GS H5XSG5_9FIRM/3-141          AC H5XSG5.1
#=GS A0A0E0JPS9_ORYPU/72-180     AC A0A0E0JPS9.1
#=GS A0A0D3CUP4_BRAOL/127-288    AC A0A0D3CUP4.1
#=GS A0A1I9LQR3_ARATH/139-300    AC A0A1I9LQR3.1
#=GS A0A0C2SB97_AMAMU/5-166      AC A0A0C2SB97.1
#=GS A9UZC4_MONBE/137-295        AC A9UZC4.1
#=GS B1I3D3_DESAP/2-138          AC B1I3D3.1
#=GS A0A094G5M4_9PEZI/9-186      AC A0A094G5M4.1
#=GS A0A1W5D424_9LECA/17-193     AC A0A1W5D424.1
#=GS A0A1S6IUK5_9FIRM/2-139      AC A0A1S6IUK5.1
#=GS A0A222EP59_9MOLU/4-148      AC A0A222EP59.1
#=GS A0A1E5VEK9_9POAL/69-156     AC A0A1E5VEK9.1
#=GS W6MJY2_9ASCO/3-172          AC W6MJY2.1
#=GS A0A101V9L1_9FIRM/2-137      AC A0A101V9L1.1
#=GS A0A0Q9JEL4_9BACL/2-75       AC A0A0Q9JEL4.1
#=GS R5VG41_9FIRM/1-138          AC R5VG41.1
#=GS E1ZPN0_CHLVA/23-186         AC E1ZPN0.1
#=GS W6ZIV6_COCMI/3-177          AC W6ZIV6.1
#=GS A0A1S8VWU3_9FUNG/7-167      AC A0A1S8VWU3.1
#=GS A0A0B1PAS8_UNCNE/6-187      AC A0A0B1PAS8.1
#=GS A0A286UQI9_9HOMO/5-172      AC A0A286UQI9.1
#=GS A0A1D6RT66_WHEAT/61-222     AC A0A1D6RT66.1
#=GS A0A0A2JB15_PENEN/9-209      AC A0A0A2JB15.1
#=GS E6R1X9_CRYGW/6-156          AC E6R1X9.1
#=GS R7GK70_9CLOT/2-148          AC R7GK70.1
#=GS A0A0L0SPA8_ALLMA/16-176     AC A0A0L0SPA8.1
#=GS K1Y5I5_MARBU/5-178          AC K1Y5I5.1
#=GS A0A166E138_9HOMO/5-171      AC A0A166E138.1
#=GS A0A0D1E4C6_USTMA/4-160      AC A0A0D1E4C6.1
#=GS I1BVU8_RHIO9/58-128         AC I1BVU8.1
#=GS E7QFM5_YEASZ/3-166          AC E7QFM5.1
#=GS A0A1J6KKD1_NICAT/130-291    AC A0A1J6KKD1.1
#=GS A0A1H3NH82_9CLOT/1-139      AC A0A1H3NH82.1
#=GS A0A0M2U2D8_9FIRM/2-83       AC A0A0M2U2D8.1
#=GS A0A1J7IRC4_9PEZI/7-182      AC A0A1J7IRC4.1
#=GS I2AWS4_FRANT/6-162          AC I2AWS4.1
#=GS A0A1Y3QQX3_9FIRM/2-140      AC A0A1Y3QQX3.1
#=GS G0SG55_CHATD/7-56           AC G0SG55.1
#=GS A6QVA5_AJECN/9-230          AC A6QVA5.1
#=GS A0A0T6AS69_9BACT/4-91       AC A0A0T6AS69.1
#=GS A0A0E0N3L5_ORYRU/59-214     AC A0A0E0N3L5.1
#=GS A0A2A1ZQI6_9BACT/1-147      AC A0A2A1ZQI6.1
#=GS F0Y6R2_AURAN/387-550        AC F0Y6R2.1
#=GS A0A0U5C967_9EURO/8-210      AC A0A0U5C967.1
#=GS A0A067P7Z7_9HOMO/5-175      AC A0A067P7Z7.1
#=GS A0A0D9NMY4_METAN/5-180      AC A0A0D9NMY4.1
#=GS B7FPS6_PHATC/7-165          AC B7FPS6.1
#=GS A0A2G3CY28_CAPCH/33-199     AC A0A2G3CY28.1
#=GS B8I7B8_CLOCE/2-140          AC B8I7B8.1
#=GS A0A1Q4R168_9CYAN/1-146      AC A0A1Q4R168.1
#=GS A0A1E4THY8_9ASCO/3-163      AC A0A1E4THY8.1
#=GS A0A0B0N0K8_GOSAR/143-304    AC A0A0B0N0K8.1
#=GS A0A1L9PAK8_ASPVE/8-218      AC A0A1L9PAK8.1
#=GS A0A0D2XV26_FUSO4/6-181      AC A0A0D2XV26.1
#=GS I0Z068_COCSC/8-168          AC I0Z068.1
#=GS A0A0U1LL38_TALIS/6-210      AC A0A0U1LL38.1
#=GS A0A1L4BPX2_9GAMM/2-163      AC A0A1L4BPX2.1
#=GS A7TKY2_VANPO/3-166          AC A7TKY2.1
#=GS A0A251T1X7_HELAN/134-295    AC A0A251T1X7.1
#=GS Q6CMZ0_KLULA/7-170          AC Q6CMZ0.1
#=GS A0A0S4PHB8_9BACT/7-150      AC A0A0S4PHB8.1
#=GS A0A225X429_9STRA/6-166      AC A0A225X429.1
#=GS A0A223D6W4_9BACL/2-140      AC A0A223D6W4.1
#=GS S9VWI0_SCHCR/5-179          AC S9VWI0.1
#=GS C9SFM9_VERA1/6-181          AC C9SFM9.1
#=GS K2RQK5_MACPH/3-178          AC K2RQK5.1
#=GS A0A1L7WWJ7_9HELO/8-187      AC A0A1L7WWJ7.1
#=GS A0A0D9V6R0_9ORYZ/68-176     AC A0A0D9V6R0.1
#=GS A0A164TJH4_9HOMO/5-172      AC A0A164TJH4.1
#=GS A0A133Y7K7_9FIRM/24-165     AC A0A133Y7K7.1
#=GS A0A0C7N700_9SACH/3-166      AC A0A0C7N700.1
#=GS A0A072P260_9EURO/8-190      AC A0A072P260.1
#=GS A0A0H5C0W5_CYBJA/49-213     AC A0A0H5C0W5.1
#=GS F5L8P8_9BACI/2-139          AC F5L8P8.1
#=GS R6YTL2_9CLOT/1-138          AC R6YTL2.1
#=GS A0A0K2DTD2_PISSA/11-160     AC A0A0K2DTD2.1
#=GS A0A1F6Q393_9BACT/3-87       AC A0A1F6Q393.1
#=GS Q5NI47_FRATT/24-163         AC Q5NI47.1
#=GS D8M8F8_BLAHO/38-185         AC D8M8F8.1
#=GS J9IM14_9SPIT/18-187         AC J9IM14.1
#=GS A0A1B6Q6J9_SORBI/68-240     AC A0A1B6Q6J9.1
#=GS A0A200R8C6_9MAGN/16-177     AC A0A200R8C6.1
#=GS E3QFU9_COLGM/5-180          AC E3QFU9.1
#=GS A0A180GCB1_PUCT1/6-154      AC A0A180GCB1.1
#=GS A0A177VIL7_9BASI/646-803    AC A0A177VIL7.1
#=GS A0A0L0DPV4_THETB/2-144      AC A0A0L0DPV4.1
#=GS A0A0J8R1P8_COCIT/8-144      AC A0A0J8R1P8.1
#=GS W6QHI0_PENRF/9-200          AC W6QHI0.1
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A0A1M2VVJ9_TRAPU/3-72                  ......................................................................................................................................rwyv---.----.--.-.-.-.-----------.........-.....-.-.---..-----.........................................---------..--------....-...------.---..-.....-..--.....-.-..-..--.--........................--.--.--..------...-.-..-.-...-...--..-...--......-..-..Q...............A..E..SVS...H...HLS.............S.P.V.L.R...HT.........................................SL.K.Ps......yAC...I...K...S..I..RA..YF.......A......S..I..PR.................P..V......K...........D...E.........E.LIFVGD.....RLLTDVVMANR..M..S..-----------rra...........................................................
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A0A1S2YAN5_CICAR/145-306               .........................................................................................................................................l-EGiVCST.MV.I.L.K.DPKLAVPHISV.........P.....D.I.RYI..DWAA-.........................................-LRRKGFKG..VVFDKDNT....I...TAPYSL.TPW..P.....L..LE.....S.A..L..EC.CK........................SE.FG.P-..DIAVFS...N.S..A.G...L...RE.yD...HD......G..S..K...............A..R..NLE...K...TLG.............I.K.V.I.R...HR.........................................VK.K.P.......gGT...A...E...E..V..EK..HF.......G......C..E..--.................-..-......-...........S...S.........Q.LIMVGD.....RPFTDIVYGNR..N..G..-FLTILTEP--ls............................................................
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B9S317_RICCO/147-308                   ........................................................................................................................................ve--GiIASV.SV.F.V.K.EQHLTLPHVSV.........R.....D.I.RYI..DWAE-.........................................-LHQRGFKG..VVFDKDNT....I...TVPYTL.TLC..G.....Y..LQ.....S.S..I..EQ.CK........................SV.FG.N-..DLAVFS...N.S..A.G...L...YE.yD...HD......G..S..K...............A..R..ALE...K...AIG.............I.K.V.I.R...HR.........................................VK.K.P.......aGT...A...E...E..I..EK..HF.......G......C..K..--.................-..-......-...........S...S.........Q.LVMVGD.....RPFTDVVYGNR..N..G..-FFTILTE---pls...........................................................
C1E9A6_MICCC/1-148                     .........................................................................................................................................r---.----.--.-.-.-.--DLAVPHLEC.........R.....D.I.NGV..DFVA-.........................................-LKDAGFKA..VVFDKDNT....L...TRPYEK.KVA..A.....D..VA.....A.A..L..ET.CV........................RA.FG.ID..NVAVLS...N.S..A.G...L...AQ.fD...PE......G..K..V...............A..D..EME...R...ALG.............I.S.F.L.R...HS.........................................SK.K.P.......aGN...C...D...A..L..VR..KF.......G......C..D..--.................-..-......-...........A...N.........E.MIFVGD.....RYLTDVVYGNR..H..G..MFTVR------vepf..........................................................
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A0A1S4A9P8_TOBAC/130-218               ........................................................................................................................................ve--G.IACF.TG.I.LyK.NKNLAIPNVFV.........P.....D.I.RYI..DWAE-.........................................-LKKRGFEG..VVFDKDNT....I...TVPYSL.NLW..S.....P..LA.....S.S..I..GQ.CK........................SL.FG.D-..NIAVFS...N.S..A.G...V...K-..-...--......-..-..-...............-..-..---...-...---.............-.-.-.-.-...--.........................................--.-.-........--...-...-...-..-..--..--.......-......-..-..--.................-..-......-...........-...-.........-.------.....-----------..-..-..-----------k.............................................................
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A0A1C3YKG4_GIBZE/6-181                 ..........................................................................................................................................LSA.SLNI.TR.L.I.F.KPSLCLPHHTV.........S.....T.F.NDL..PIPLEkg....................................lqqDGRKVEIKA..VVLDKDDC....F...AYPDSI.EVY..E.....S..YK.....T.H..F..EK.LR........................LA.YP.GR..KLLVVS...N.T..A.G...A...TS.wD...KN......L..K..L...............A..A..EVE...K...NTG.............V.M.V.L.S...HS.........................................VK.K.P........GC...G...Q...E..I..ME..YF.......K......K..H..PEt...............gV..T......N...........P...G.........H.VAFVGD.....RLTTDMMLANM..T..G..GWGFWVKDGV-i.............................................................
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A0A0D9YG31_9ORYZ/59-214                ......................................................................................................................................agva---.--AV.AA.V.AaS.EPRLALPHVSV.........Q.....D.I.RWL..DWGE-.........................................-LRRAGFRG..VVFDKDNT....L...TAPYAP.GLW..P.....P..LA.....A.A..F..DQ.CR........................AA.FP.PG..SLAVYS...N.S..A.G...L...KQ.yD...PD......G..L..E...............A..T..AIE...A...V--.............-.-.-.-.I...QG.........................................VH.K.P.......gGE...A...K...E..I..ES..YF.......G......C..S..--.................-..-......-...........A...S.........N.LVLVGD.....RYFTDVVYGNR..N..G..-FLTVLTEP--ln............................................................
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A0A067F482_CITSI/144-285               ....................................................................................................................................vegivs---.--ST.VV.F.A.K.DRHLALPHVTV.........P.....D.I.RYI..DWAE-.........................................-LQRRGFKG..VVFDKDNT....L...TAPYSL.TLW..G.....P..LS.....S.S..I..EQ.CK........................SV.FG.H-..DIAVFS...N.S..A.G...L...YE.yD...ND......A..S..K...............A..R..KLE...G...KIG.............I.K.V.I.R...HR.........................................VK.K.P.......aGT...A...E...E..I..EK..HF.......G......C..Q..--.................-..-......-...........S...S.........Q.LIMV--.....-----------..-..-..-----------dmcri.........................................................
M1WBX8_CLAP2/5-180                     ..........................................................................................................................................LSA.SLHA.TR.L.L.F.KPSICLPHYTV.........S.....T.F.NEL..PIPLDkg....................................laqLGHRSDIRA..VVLDKDDC....F...AYPDAK.EVY..G.....P..YQ.....K.H..F..DD.LK........................RA.YP.GR..KLLVVS...N.T..S.G...A...TT.wD...RD......L..K..Q...............A..A..LVE...K...STG.............I.H.V.L.S...HS.........................................VK.K.P........GC...G...A...Q..I..MA..YF.......E......E..H..PEs...............gV..T......D...........P...S.........H.VAVVGD.....RLTTDMMLANM..M..G..GWGFWIKDGV-v.............................................................
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G3Y9M0_ASPNA/8-192                     ..........................................................................................................................................LRAfNLAV.TT.L.L.K.TPSQFLPHLTI.........P.....T.I.THL..PENLGpei...................................lpsASKPPTIRA..LVLDKDNT....L...CHPKTT.SFP..S.....E..IL.....S.K..L..HA.LRts...................ptsPF.TK.DN..SILIVS...N.R..A.G...S...HP..R...YD......A..E..V...............R..E..LEK...E...L-Ge..........lqI.P.V.F.R...LPe......................................gsEK.K.P........FC...G...K...E..V..LE..WF.......R......E..R..GV.................V..S......R...........A...D.........E.IAVVGD.....RLGTDVLMAVQ..M..G..SWSVWCRDGVT..............................................................
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R6P6A8_9CLOT/1-138                     ........................................................................................................................................mf---.----.--.-.-.-.----IYPNEYF.........N.....K.V.EEI..TIEF-.........................................-LKKNKIKA..LILDVDNT....L...I-NYEK.RLP..E.....K..VA.....K.W..A..RE.LK........................GQ.GI.--..KLYILS...N.T..N.-...-...--..-...-Q......E..E..K...............V..K..RVA...N...ALE.............I.P.-.Y.E...YF.........................................AK.K.Pl......kSG...F...L...K..V..QK..SL.......N......-..-..--.................-..E......K...........P...E.........N.IGVVGD.....QIFTDIIGGNR..C..K..MF-TI------lvdpie........................................................
A0A168E3M7_9HYPO/5-180                 ..........................................................................................................................................LSA.SLNV.TK.L.L.F.NPGLCLPHCTV.........L.....T.F.NDL..PIPLDkg....................................lqrAGHKSDIRA..VVLDKDDC....F...AYPDTK.EVY..E.....P..YK.....K.H..F..EE.LR........................RA.YP.GR..KLLIVS...N.T..S.G...A...TS.wD...RD......L..R..Q...............A..L..QVE...Q...RTG.............V.H.V.L.P...HA.........................................VK.K.P........GC...A...A...E..I..MT..YF.......R......R..H..PEt...............gV..T......D...........A...S.........Q.IAVVGD.....RLTTDMMLANM..M..G..GWGVWIRDGV-m.............................................................
A0A1I0G6C1_9BACI/2-141                 ........................................................................................................................................lk---.----.--.-.-.-.---KFLPNEHV.........K.....T.V.FEI..TPEK-.........................................-LKEKGIQG..IITDLDNT....L...VAWDQK.DAT..D.....E..II.....E.-..W..FK.LM........................KD.HG.I-..QVTVMS...N.N..-.-...-...--..-...-N......E..E..R...............V..R..HFS...I...PLN.............V.P.-.F.V...YK.........................................AR.K.P........LS...K...A...-..-..--..FK.......K......A..Q..KE................mN..L......N...........R...D.........Q.IVVVGD.....QILTDVLGGNS..S..H..-----------fytilvvpvvq...................................................
A0A1Y2FSG2_9ASCO/4-190                 ...................................................................................................................................saislgl---.----.-S.C.L.F.NPSQLRPSLVL.........Q.....C.F.SQI..PQDIPaalash............................aivddcaKRRFSDIRA..LVLDKDNC....F...AEPHSL.QVH..A.....S..CQ.....S.R..F..SL.LK........................EQ.YP.GA..RLLIVS...N.T..T.G...C...LP..S...KRsgvngpS..N..D...............L..S..QLQ...E...NLG............gP.H.V.L.V...HE.........................................QR.K.P........GC...G...D...E..V..MA..YL.......R......E..H..AQ.................V..T......H...........P...S.........Q.VCVVGD.....RLFTDILMANR..M..G..AHSIWLQRGV-l.............................................................
A0A067T6R8_GALM3/5-167                 ......................................................................................................................................vpgi---.-LVP.FQ.L.L.L.YPRLVIPALVV.........N.....D.I.RQV..DFLA-.........................................-LKRAGYRG..AVFDKDNC....L...TLPHRD.TLV..P.....E..LQ.....E.S..W..KS.CR........................ET.FG.EG..NVLIVS...N.S..A.G...T...YL..D...AG......G..I..Q...............S..E..SVA...Y...HLG.............V.P.V.L.S...HK.........................................SL.K.Pa......ySC...I...T...A..I..RT..YF.......S......S..L..RF.................P..I......H...........D...H.........Q.LIVVGD.....RVFTDIVLGNR..M..-..-----------rmqanrh.......................................................
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E0I340_9BACL/2-139                     ........................................................................................................................................fe---.----.--.-.-.-.---RLLPNLRL.........N.....S.V.YDL..DIEA-.........................................-LARQGIKG..IITDLDNT....L...VGAKEP.LAT..P.....R..LV.....E.W..L..NK.LR........................ER.GF.K-..-VVIVS...N.N..-.-...-...--..-...-N......E..T..R...............V..S..RFA...N...PLG.............I.P.-.Y.I...HA.........................................AR.K.P........AN...R...-...A..F..HR..AF.......-......-..E..LL.................A..L......S...........P...E.........Q.VVIMGD.....QMLTDVLGGNR..L..G..VYTIL------vppi..........................................................
A0A084QDV2_STAC4/5-180                 ..........................................................................................................................................LSA.SLNI.TK.L.V.F.KPSLCLPHHTV.........S.....T.F.NDL..PIPLDkg....................................lkkEGRDVRIKA..VILDKDDC....F...AIPDTS.EVY..K.....P..YK.....E.K..F..EA.LK........................AA.YP.GR..RLLVVS...N.T..A.G...A...TS.wD...RT......L..Q..L...............A..G..ELE...K...NTG.............V.H.V.L.Q...HS.........................................VK.K.P........GC...G...S...E..I..ME..YF.......R......K..H..PEt...............gV..T......D...........P...A.........Q.VAIVGD.....RLTTDMMLANM..M..G..GWGFWVKDGV-v.............................................................
A0A0S7DUA1_9EURO/9-208                 ..........................................................................................................................................LRGfNHAV.QT.L.L.R.NPSQFLPHLTI.........P.....T.F.THL..PENLGphlhrqpps.......................avnpgekpaATKSPTIRA..LVLDKDNT....L...CPPKTT.TFP..P.....Q..II.....D.K..L..SA.LRnspt...............spfnqST.AP.D-..SILIVS...N.R..A.G...S...HP..R...FD......A..E..V...............R..E..IEE...R...LSSl...........rI.P.V.F.R...LPe......................................gsEK.K.P........FC...G...K...E..V..VD..WF.......R......E..R..GV.................V..T......R...........A...D.........E.IAVVGD.....RLGTDVLMAAM..M..G..SWSVWCRDGV-y.............................................................
R7GFR9_9CLOT/1-138                     .......................................................................................................................................mnl---.----.--.-.-.-.-----YPNLLL.........N.....K.V.EEI..TLDI-.........................................-LKKNKINA..LILDVDNT....L...I-DYKK.NLS..N.....N..VV.....E.W..A..KN.LK........................AN.GI.--..KLYILS...N.T..N.-...-...--..-...-H......E..E..K...............V..K..NVA...N...KLQ.............I.S.Y.I.N...F-.........................................AK.K.Pf......kKC...F...L...K..V..QS..IL.......K......E..E..--.................-..-......-...........P...S.........N.IAVVGD.....QIFTDIIGGNR..C..N..MFTIL------vepid.........................................................
S3CRP5_GLAL2/6-180                     ..........................................................................................................................................ISA.TLSL.FR.L.V.T.KPSLCLPQATV.........S.....T.F.NDL..PIPLNka....................................fekEYKSVDIRA..VVLDKDNC....F...AWPKEN.VVA..K.....E..NE.....E.K..F..AL.LK........................EA.YP.AN..RILVAS...N.T..A.G...S...SS..D...PT......L..S..L...............A..E..TLT...K...NTN.............L.P.V.L.T...HR.........................................LK.K.P........SC...G...P...E..I..MS..YF.......K......N..H..PEt...............gV..T......H...........P...S.........H.IVVIGD.....RLTTDVMLANT..M..G..AYSIFISDGV-m.............................................................
A0A2C5ZWL1_9HYPO/5-180                 ..........................................................................................................................................ISA.SLNA.SR.L.L.F.RPSLCLPHYTV.........P.....T.F.NDL..PIPLDrd....................................iqkDGRKADIKA..VVLDKDDC....F...AYPDTN.EVH..E.....P..YR.....Q.H..F..EA.LK........................RA.YP.GR..RLLVVS...N.T..A.G...A...TG.wD...KQ......L..K..Q...............A..A..QLE...K...STG.............V.F.V.L.A...HS.........................................AK.K.P........GC...G...S...E..V..MA..YF.......K......Q..H..PEt...............gV..T......H...........P...S.........H.VAVVGD.....RLMTDVMLANM..M..G..SWGFWIRDGV-v.............................................................
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A0A166RP85_9HOMO/5-179                 ....................................................................................................................................ipgllv---.---P.FH.L.L.V.NPRLVIPHIIV.........N.....D.I.RQV..DFRA-.........................................-LKRAGYKG..AVFDKDNC....I...TLPQQD.RLV..P.....E..LQ.....D.S..W..RE.CR........................EV.FG.EG..NVLIVS...N.S..A.G...T...PS..D...AG......G..I..Q...............A..E..SVS...H...HLK.............V.P.V.L.Q...HA.........................................SL.K.Ps......yAC...I...K...G..I..RA..YFaslpgnkA......E..S..KE.................S..S......R...........PprdS.........E.LVIIGD.....RIFTDVLLANR..M..R..SSSS-------qsrl..........................................................
A0A061ACF7_9MOLU/1-81                  ......................................................................................................................................maly---.----.--.-.-.-.--KKIIPEIYV.........D.....S.V.KDI..PYKS-.........................................-LKVQGIKA..LLFDLDNT....L...IDYEQT.KLD..T.....D..TS.....N.F..L..IE.LE........................KD.FL.V-..--IIIS...N.S..-.-...-...--..-...--......-..-..-...............-..-..---...-...---.............-.-.-.-.-...--.........................................--.-.-........--...-...-...-..-..--..--.......-......-..-..--.................-..-......-...........-...-.........-.------.....-----------..-..-..-----------yekrvygavg....................................................
K5Y0B3_AGABU/5-164                     ....................................................................................................................................ipgllv---.---P.FQ.L.L.I.HPRIVIPNVII.........K.....D.I.RHL..DFAA-.........................................-LRKAGYRG..AIFDKDNC....L...TVPYED.TLV..P.....E..LE.....S.A..W..TE.CH........................KT.FG.KG..NVIIVS...N.S..A.G...T...HT..D...PG......G..I..Q...............S..E..SVS...H...HLQ.............V.P.V.L.Y...HK.........................................SF.K.Ps......ySC...I...K...S..I..RS..YF.......S......T..L..PR.................P..I......S...........D...D.........E.LIIIGD.....RIFTDIVLSNR..M..-..-----------rftn..........................................................
R7NI49_9MOLU/1-137                     ........................................................................................................................................mq---.----.--.-.-.-.---NFIPDMYQ.........K.....S.I.YDI..DYKK-.........................................-LKEKGIKC..LLFDLDNT....L...VPVNID.IPT..K.....K..VK.....E.L..F..MT.LE........................QD.FK.--..-VIIIS...N.S..-.G...-...--..-...--......K..K..R...............L..I..PFK...E...GLN.............V.D.V.S.A...-S.........................................SH.K.P........FK...K...Ky.lK..I..MK..IY.......K......F..-..--.................-..-......K...........Y...H.........E.IAAIGD.....QLLTDIYGANR..V..G..ITSILIN----qi............................................................
Q84VV0_ARATH/134-295                   ..........................................................................................................................................IEGiVSSV.SV.V.V.K.DRQFVLPHVSV.........K.....D.L.RYI..DWEV-.........................................-LKRKGFKG..VVFDKDNT....L...TAPYSL.AIW..P.....P..LR.....P.S..I..ER.CK........................AV.FG.H-..DIAVFS...N.S..A.G...L...TE.yD...HD......D..S..K...............A..K..ALE...A...EIG.............I.R.V.L.R...HR.........................................VK.K.P.......aGT...A...E...E..V..EK..HF.......G......C..T..--.................-..-......-...........S...S.........E.LIMVGD.....RPFTDIVYGNR..N..G..-FLTVLTEP--ls............................................................
A0A1L0BW07_9ASCO/6-173                 .........................................................................................................................................a-SA.TLNA.SR.L.I.Y.NPTLCLPHVTV.........K.....S.F.DNL..PIPLR........................................iPGHTTEIKG..VVLDKDNC....F...AKDHDD.KVW..P.....A..YA.....E.V..W..KK.LQ........................DA.YP.KE..RLLIVS...N.S..A.G...T...ND..D...AD......Y..A..Q...............A..I..KLE...T...DTG.............V.T.V.L.R...HP.........................................TK.K.P........GC...H...E...E..I..MA..YF.......S......E..Q..-G.................I..S......K...........P...S.........E.IAVVGD.....RLFTDMLMANM..M..G..AWGIWLSEGVE..............................................................
V9ER00_PHYPR/5-156                     ...............................................................................................................................knccdcvyscs---.----.--.-.-.-.--------LCY.........S.....D.V.TEV..PFQT-.........................................-LRDRGFRG..VIFDKDNT....L...TVPHKL.EIA..P.....H..LA.....P.S..L..EE.CR........................RV.FG.DS..GVVIFS...N.S..A.G...S...TD..D...KD......G..V..E...............A..K..KIE...E...ELQ.............V.A.V.L.R...HN.........................................QK.K.P........GG...I...T...F..V..KK..HF.......G......E..V..--.................-..-......D...........P...Q.........T.LVVIGD.....RYSTDVLFGNL..N..G..LL-T-------irteqft.......................................................
A0A0D2D6Z2_9EURO/8-184                 ....................................................................................................................................palrls---.---L.AY.A.L.H.DPSALLPHRTI.........P.....T.L.LWL..PLPVGp.......................................sLPTKPTIRA..IVLDKDNT....L...CPPETA.KMH..Q.....A..YL.....N.K..I..EK.IKqs...................tefSQ.NA.-H..SILIVS...N.T..A.G...S...SS..A...PE......H..E.aE...............A..K..QLE...L...ELG.............L.P.V.L.R...QHp.......................................dRK.K.P........LC...G...P...D..I..LK..FF.......R......D..H..GV.................T..D......D...........P...R.........E.IVVVGD.....RLATDVLVAHQ..L..G..SWSVWCKEG--wr............................................................
#=GC seq_cons                          ......................................................................................................................................................h.h.h.p.phhlPphhl.........s.....s.l.ppl..shsh...........................................h+ptsl+u..lVhDKDNs....l...shPpss.plh..s.....t..ht.....p.t..h..cp.h+........................ps.as.t...pllIVS...N.o..A.G...........c....s......t..p..p...............u..p..tlp...p...thu.............l.s.V.l.t...Hp.........................................sK.K.P........ss...t...p...c..l..hp..aF.......t......p..p...............................t...........s...p.........p.lslVGD.....RlhTDllhuNh..h..G...ashhh.....h.............................................................
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