#=GF ID   PI-TkoII_IV
#=GF AC   PF18714.5
#=GF DE   DNA polymerase II intein Domain IV
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF08478
#=GF GA   25.00 25.00;
#=GF TC   30.30 40.40;
#=GF NC   24.40 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   16493661
#=GF RT   Crystal structure of intein homing endonuclease II encoded in
#=GF RT   DNA polymerase gene from hyperthermophilic archaeon Thermococcus
#=GF RT   kodakaraensis strain KOD1.
#=GF RA   Matsumura H, Takahashi H, Inoue T, Yamamoto T, Hashimoto H,
#=GF RA   Nishioka M, Fujiwara S, Takagi M, Imanaka T, Kai Y;
#=GF RL   Proteins. 2006;63:711-715.
#=GF RN   [2]
#=GF RM   21914805
#=GF RT   Structural and mutational studies of a hyperthermophilic intein
#=GF RT   from DNA polymerase II of Pyrococcus abyssi.
#=GF RA   Du Z, Liu J, Albracht CD, Hsu A, Chen W, Marieni MD, Colelli KM,
#=GF RA   Williams JE, Reitter JN, Mills KV, Wang C;
#=GF RL   J Biol Chem. 2011;286:38638-38648.
#=GF DR   INTERPRO; IPR041005;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain can be found in the hyperthermophilic archaeon
#=GF CC   Thermococcus kodakaraensis Pol-2 intein. It is suggested to be a
#=GF CC   potential DNA binding domain [1, 2].
#=GF SQ   3
#=GS DPOL_METJA/1006-1154  AC Q58295.2
#=GS DPOL_THEKO/975-1123   AC P77933.3
#=GS C6A2Y2_THESM/618-767  AC C6A2Y2.1
DPOL_METJA/1006-1154             KKLTCVDKEVVINIPKRLINADEEEIKDLVITK--HKDKAFFVKLKKTLEDIENNK--LKVIFDDCILYLKELGLIdyniikKINKVDIKILDEEKFKAYKKYFDTVIEHGNF--KKGRCNIQYIKIKDYIANIPDKEFEDCEIGAYSG-------kinall
DPOL_THEKO/975-1123              RRLELPERNHVLNLVELLLGTPEEETLDIVMTIPVKGKKNFFKGMLRTLRWIFGEE-KRPRTARRYLRHLEDLGYV......RLKKIGYEVLDWDSLKNYRRLYEALVENVRYNGNKREYLVEFNSIRDAVGIMPLKELKEWKIGTLNGFRMSPLI......
C6A2Y2_THESM/618-767             KKVKLNEKEVTINIPELILRLPDEATADIVMTIPVKGRKNFFKGMLRTLRWIFGEESKRIRTFNRYLFHLEKLGFV......KLLPRGYEVTDWEGLKIYKQLYEKLVESLRYNGNKREYLVMFNDIKDVISSFPQKELEEWKIGTLNGFRMDCIL......
#=GC seq_cons                    KKLcLsEKEVVINIPELLLssPEEETtDIVMTIPVKG+KNFFKGMLRTLRWIFGEE.KRhRTFcRYLhHLE-LGaV......KLpKlGYEVLDWEuLKsYK+LYEsLVEslRYNGNKREYLVpFNcIKDsIushPpKELEEWKIGTLNGFRMssll......
//