#=GF ID PI_PP_I
#=GF AC PF18363.6
#=GF DE Phosphoinositide phosphatase insertion domain
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF03527
#=GF GA 28.50 28.50;
#=GF TC 29.00 33.00;
#=GF NC 27.70 23.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 81514348 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 23843460
#=GF RT Identification and structural characterization of a Legionella
#=GF RT phosphoinositide phosphatase.
#=GF RA Toulabi L, Wu X, Cheng Y, Mao Y;
#=GF RL J Biol Chem. 2013;288:24518-24527.
#=GF DR INTERPRO; IPR040769;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in the effector protein SidP present in
#=GF CC Legionella longbeachae. SidP functions as a
#=GF CC Phosphoinositide-3-phosphatase specifically hydrolyzing
#=GF CC Phosphoinositide(3)P, referred to as PI(3)P, and PI(3,5)P2. The
#=GF CC domain is inserted into the N-terminal portion of the catalytic
#=GF CC domain and is referred to as the appendage or insertion (I)
#=GF CC domain [1].
#=GF SQ 24
#=GS A0A0W0U8A7_9GAMM/216-311 AC A0A0W0U8A7.1
#=GS A0A0W0Z0R7_9GAMM/192-285 AC A0A0W0Z0R7.1
#=GS A0A098GC21_LEGMI/192-291 AC A0A098GC21.1
#=GS A0A0W0XN98_9GAMM/192-288 AC A0A0W0XN98.1
#=GS A0A0W1A5M3_9GAMM/193-290 AC A0A0W1A5M3.1
#=GS A0A0W0ZU25_9GAMM/187-280 AC A0A0W0ZU25.1
#=GS A0A0W0SUY5_9GAMM/210-312 AC A0A0W0SUY5.1
#=GS A0A0W0VCA5_9GAMM/339-419 AC A0A0W0VCA5.1
#=GS A0A0W0XL45_9GAMM/190-288 AC A0A0W0XL45.1
#=GS A0A098FZK5_9GAMM/190-283 AC A0A098FZK5.1
#=GS A0A0W1AJJ5_9GAMM/192-277 AC A0A0W1AJJ5.1
#=GS A0A0W0VLD5_9GAMM/192-296 AC A0A0W0VLD5.1
#=GS D3HMN4_LEGLN/189-282 AC D3HMN4.1
#=GS D3HMN4_LEGLN/189-282 DR PDB; 4JZA A; 189-282;
#=GS D3HMN4_LEGLN/189-282 DR PDB; 4JZA B; 189-282;
#=GS Q5ZZ81_LEGPH/192-285 AC Q5ZZ81.1
#=GS A0A0W0WH40_9GAMM/189-282 AC A0A0W0WH40.1
#=GS G9ELQ2_9GAMM/183-278 AC G9ELQ2.1
#=GS A0A078KW91_9GAMM/229-327 AC A0A078KW91.1
#=GS A0A0W0WP31_9GAMM/196-296 AC A0A0W0WP31.1
#=GS A0A222P5Z4_9GAMM/211-311 AC A0A222P5Z4.1
#=GS A0A0W0VCA5_9GAMM/215-317 AC A0A0W0VCA5.1
#=GS A0A378HXK6_9GAMM/196-296 AC A0A378HXK6.1
#=GS A0A6F8SZM7_9GAMM/193-286 AC A0A6F8SZM7.1
#=GS A0A3S0W1G1_9GAMM/189-287 AC A0A3S0W1G1.1
#=GS A0A0W0YZG1_LEGSP/191-287 AC A0A0W0YZG1.1
A0A0W0U8A7_9GAMM/216-311 ................TPDWFRRL....PLYQQAYFHG........SNTHVNSIENLALDLNKL.LVIWLKLK.......TTS-..SL.QEELRNIAA.GETNLPAWFRDLPANQQNLIRNLV...SptvTVSEVTNNL-r.............
A0A0W0Z0R7_9GAMM/192-285 ................TPAWFRHL....SEYQQAYFCN........LDMKKLDATTVMQDFNSF.MSVWESTQ.......KNSL..SL.ASDLNKIKT.HAAPYPNWFNSLNVAQQAMVRVLS...E...DPASFDSHLR..............
A0A098GC21_LEGMI/192-291 ................TPDWFRRL....PSDQQLYFHS........IDNQDVA-VGLKFQLNKFkLTAWPAIKalyeakrQHSV..VF.QQSLQAIKE.DK-NLPSWYTSLALEQQRFVKEMV...Sa.vD---------lrelast.......
A0A0W0XN98_9GAMM/192-288 ................TPDWFRAL....PVQQQVYLHG........LQPTPTKLEMLKGSVNDF.TILWNDIK.......KDK-..NI.DNELLKIKN.QSEVVPSWFSSLTSARREFITAVL...R...----------sssnpsadisqaln
A0A0W1A5M3_9GAMM/193-290 ................TPQWFREL...kQEYQQVYFSN........LKIHPISPKTIRQDLNQL.LLKWKTAK.......TTSL..NL.LEDLNRIKN.NKTPLPLWFETFSPGQKELFRFLA..tAc.sSAKEIDTEI-d.............
A0A0W0ZU25_9GAMM/187-280 ................TPPWFYTL....NEHQQAYFCN........LDRKIESPTEVVHDFNDF.LFNWDSIK.......KKAI..SL.TTDLQQIAA.GSSPLPLWFNQLSPHLREMMRILA...A...DPYTVDKKLD..............
A0A0W0SUY5_9GAMM/210-312 ................TPKWFRAL....SPLMQTYLHScip.eyvmGESREAILSKLKFSLNQF.TIKWHEIK......lQQGM..QL.STELSGIAN.DK--FPTWYTALPPHEQRLVKLFC..dSq.lTAEKITSQL-s.............
A0A0W0VCA5_9GAMM/339-419 hfnqltvlelpgslsf--------....----------........--------------LNGF.IGEWNKLK......lEQGA..AL.DHDLKQIAQmGHAKIPIWLKSLDPQHQLVLRILA...E..tKLM-------tasmsld.......
A0A0W0XL45_9GAMM/190-288 ...............l-PKWLDSL....PYYQQIFFLT........SPEECQTATQLNSENNAI.IAWWRKAT......eAKPL..SN.ADYLAIVDG.SVKKQPKWFQGIPENRRQVIRVLL..iS...EGN-------sfervegrlh....
A0A098FZK5_9GAMM/190-283 ................TPSWFRTL....EEHQQAYLCN........LQLDNVNPATVMHDLNDF.LKVWNSIK.......DESL..SL.LTELKQIAT.NALPLPAWFNKLSVSHQEMIKVLA...K...KPEEIDSKL-l.............
A0A0W1AJJ5_9GAMM/192-277 ................TPVWFRSL....QEFQKEYFVN........LEISPPNVASITSDIYKF.IRLWDELK.......STSR..DI.ILELRDIDN.--------LSQFSKAQKAVLNVLA...A...EPWCIDANL-i.............
A0A0W0VLD5_9GAMM/192-296 ...............tPPGWFRKL....PSVWQLYLHScipayllaAESNADVLNKIKMNLNDF.DLQWSKIK......hDHGL..EL.EGDLISISK.NE--FPQWFTGLKKEHQQLLKIFC...EsgySVPKIDGSF-s.............
D3HMN4_LEGLN/189-282 ................TPGWLRDL....EEYQHAYFCN........LDQGVTSYLEVIRDFNNF.LLNWASIK.......KIAL..SL.NSDLQQIVS.GSPPLPSWFNGLSVHQREMMRILA...A...DPTSLDKKL-t.............
#=GR D3HMN4_LEGLN/189-282 SS ................--HHHHCS....-HHHHHHHHC........--TT--SHHHHHHHHHHH.HHHHHHHH.......HH-S..SH.HHHHHHHHC.T-SS--HHHHTS-HHHHHHHHHHT...T...SCCCHHHHH-H.............
Q5ZZ81_LEGPH/192-285 ................TPAWFKNL....PPYQQAYYCN........LNLSSVDPKKALQHFNTF.FGNWGDIA.......KRSL..NL.TTELNQIHT.NSPPYPSWFNELSPAQQAMIRVLS...A...TPHEIKSSLK..............
A0A0W0WH40_9GAMM/189-282 ............etph----IRDL....EEYQQVYFLY........LDKSLNTGEAIKIDFNTF.YLKWLELI.......KEPE..LL.SQQLKMITQ.EGMN-VSWFSELSLSQQHMLCTLA..dK...PIDEIS----rilk..........
G9ELQ2_9GAMM/183-278 ................TPFWFRELakpkAHFMQAYFCN........FNAESIN---VSDDLALF.LAAWKDIK.......SKAL..KI.SNDLNSIAN.CS-TLPAWFDKLPLHHQEMMRVLA...Ae.kSVDEVDEKL-m.............
A0A078KW91_9GAMM/229-327 ................TPQWFRDL....TSYQQLFFLT........IEKEEISLANLKFDTNNL.ILSWQGIK.......ETNSqvTL.EQDLQAIAT.GAEPLPRWFTQLSVVHRNTIRALV...SpniSLSKFEVRM-k.............
A0A0W0WP31_9GAMM/196-296 ................TPQWFRQL....PSEQQIYFHS........IKNLDISIRDLKFQLNNFqLTTWPAIKalyeakkTHSA..VF.QQSLKSIRD.NV-RLPAWFTALSFEQQRFLKQLI..tA...KSEEL-----gsnt..........
A0A222P5Z4_9GAMM/211-311 ................TPAWFRDL....SSLMQIYLHScip.eyvvIESNEKTLEKLKFSLNQF.MLKWDEIK.......PQH-..HL.TNDLEAIRN.NK--FPTWFTSLPRHDQQLLKLFC..dAr.lSVHEIDSQL-i.............
A0A0W0VCA5_9GAMM/215-317 ...............i-PHWFRSL....SPWMQIYLHSfip.seliSKDDLKTLTGLKRNLNSL.TLQWSSIK......lEQGA..NL.HHDLENIAQ.GK--IPLWMKSLNPEHQQLLKLMA..dA...----------glseagisdeia..
A0A378HXK6_9GAMM/196-296 ................TPEWFREL....SPISQIYIHA........SEVQPSTINALKSNLTIL.EAAWKYVK.......ANMEpaPL.LKDLESIAE.DKIPVPSWFSQLSNGQQRVFRELA...S..rAVK-------egidcidsqft...
A0A6F8SZM7_9GAMM/193-286 ................TPSWFRRL....PEYQQAYFCN........LKLDVFSPKEVAQELNQF.ILAWGDIK.......GKSL..TL.ATDLKQIQT.DTPPFPNWFNQLSVQLKEMVRVLA...L...KPESIKHNL-a.............
A0A3S0W1G1_9GAMM/189-287 ................TPAWFVNL....KPEEQAYLCN........LGMESVTPEALIEDLQAL.LDNLTLIK......rGRSH..SIwTSDLDKISV.GEIPLPNWYSELSKAKQEMIKILA...G...KSGAIN----eaittfk.......
A0A0W0YZG1_LEGSP/191-287 ................TPSWFRQS....GVVEQLYFYH........TPAYCNNSGVLRKHYEAV.NFAWMKAK......aERSL..II.EADLQAIRD.NR-DLPKWFTGMAPESQKFFKSWLlfaE...TQEDIN----kgla..........
#=GC SS_cons ................--HHHHCS....-HHHHHHHHC........--TT--SHHHHHHHHHHH.HHHHHHHH.......HH-S..SH.HHHHHHHHC.T-SS--HHHHTS-HHHHHHHHHHT...T...SCCCHHHHH-H.............
#=GC seq_cons ................TPtWFRpL....s.hQQhYaps........lc.pshs.pplptclNsF.hhtWppIK.......ppuh..sL.pp-LppIss.sp.slPsWFspLssppQphl+lLs...u...sspplp....t.............
//
