#=GF ID PI_PP_I
#=GF AC PF18363.2
#=GF DE Phosphoinositide phosphatase insertion domain
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF03527
#=GF GA 28.50 28.50;
#=GF TC 30.40 34.80;
#=GF NC 27.30 26.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 23843460
#=GF RT Identification and structural characterization of a Legionella
#=GF RT phosphoinositide phosphatase.
#=GF RA Toulabi L, Wu X, Cheng Y, Mao Y;
#=GF RL J Biol Chem. 2013;288:24518-24527.
#=GF DR INTERPRO; IPR040769;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain is found in the effector protein SidP present in
#=GF CC Legionella longbeachae. SidP functions as a
#=GF CC Phosphoinositide-3-phosphatase specifically hydrolyzing
#=GF CC Phosphoinositide(3)P, referred to as PI(3)P, and PI(3,5)P2. The
#=GF CC domain is inserted into the N-terminal portion of the catalytic
#=GF CC domain and is referred to as the appendage or insertion (I)
#=GF CC domain [1].
#=GF SQ 24
#=GS A0A0W0VLD5_9GAMM/193-296 AC A0A0W0VLD5.1
#=GS G9ELQ2_9GAMM/183-278 AC G9ELQ2.1
#=GS A0A378HXK6_9GAMM/196-296 AC A0A378HXK6.1
#=GS A0A0W0ZU25_9GAMM/187-280 AC A0A0W0ZU25.1
#=GS A0A098FZK5_9GAMM/190-283 AC A0A098FZK5.1
#=GS A0A0W0SUY5_9GAMM/210-312 AC A0A0W0SUY5.1
#=GS A0A0W0VCA5_9GAMM/340-421 AC A0A0W0VCA5.1
#=GS A0A3S0W1G1_9GAMM/189-287 AC A0A3S0W1G1.1
#=GS A0A222P5Z4_9GAMM/211-311 AC A0A222P5Z4.1
#=GS A0A0W0WH40_9GAMM/187-285 AC A0A0W0WH40.1
#=GS A0A378JG11_9GAMM/192-292 AC A0A378JG11.1
#=GS A0A0W0WP31_9GAMM/196-295 AC A0A0W0WP31.1
#=GS A0A098GC21_TATMI/192-293 AC A0A098GC21.1
#=GS A0A0W0VCA5_9GAMM/215-317 AC A0A0W0VCA5.1
#=GS A0A0W0XN98_9GAMM/192-288 AC A0A0W0XN98.1
#=GS Q5ZZ81_LEGPH/192-285 AC Q5ZZ81.1
#=GS D3HMN4_LEGLN/189-282 AC D3HMN4.1
#=GS D3HMN4_LEGLN/189-282 DR PDB; 4JZA B; 189-282;
#=GS D3HMN4_LEGLN/189-282 DR PDB; 4JZA A; 189-282;
#=GS A0A0W0U8A7_9GAMM/216-311 AC A0A0W0U8A7.1
#=GS A0A0W0YZG1_LEGSP/191-287 AC A0A0W0YZG1.1
#=GS A0A078KW91_9GAMM/229-327 AC A0A078KW91.1
#=GS A0A0W1AJJ5_9GAMM/192-277 AC A0A0W1AJJ5.1
#=GS A0A0W0Z0R7_9GAMM/192-285 AC A0A0W0Z0R7.1
#=GS A0A0W1A5M3_9GAMM/193-290 AC A0A0W1A5M3.1
#=GS A0A0W0XL45_9GAMM/190-288 AC A0A0W0XL45.1
A0A0W0VLD5_9GAMM/193-296 ...............PPGWFRKL....PSVWQLYLHScipayllaAESNADVLNKIKMNLNDFDL.QWSKI.......K......hDHGL..EL.EGDLISISK.NE--FPQWFTGLKKEHQQLLKIFC.ESGYS..VPKIDGSF-s.............
G9ELQ2_9GAMM/183-278 ...............TPFWFRELakpkAHFMQAYFCN........FNAESIN---VSDDLALFLA.AWKDI.......K.......SKAL..KI.SNDLNSIAN.CS-TLPAWFDKLPLHHQEMMRVLA.-AEKS..VDEVDEKL-m.............
A0A378HXK6_9GAMM/196-296 ...............TPEWFREL....SPISQIYIHA........SEVQPSTINALKSNLTILEA.AWKYV.......Ka.....nMEPA..PL.LKDLESIAE.DKIPVPSWFSQLSNGQQRVFRELA.SRAVKegIDCIDS---qft...........
A0A0W0ZU25_9GAMM/187-280 ...............TPPWFYTL....NEHQQAYFCN........LDRKIESPTEVVHDFNDFLF.NWDSI.......K.......KKAI..SL.TTDLQQIAA.GSSPLPLWFNQLSPHLREMMRILA.-A--D..PYTVDKKL-d.............
A0A098FZK5_9GAMM/190-283 ...............TPSWFRTL....EEHQQAYLCN........LQLDNVNPATVMHDLNDFLK.VWNSI.......K.......DESL..SL.LTELKQIAT.NALPLPAWFNKLSVSHQEMIKVLA.-K--K..PEEIDSKL-l.............
A0A0W0SUY5_9GAMM/210-312 ...............TPKWFRAL....SPLMQTYLHScip.eyvmGESREAILSKLKFSLNQFTI.KWHEI.......K......lQQGM..QL.STELSGIAN.DK--FPTWYTALPPHEQRLVKLFC.DSQLT..AEKITSQLS..............
A0A0W0VCA5_9GAMM/340-421 fnqltvlelpgslsf--------....----------........--------------LNGFIG.EWNKL.......K......lEQGA..AL.DHDLKQIAQmGHAKIPIWLKSLDPQHQLVLRILA.ETKLM..TA-------smsldvs.......
A0A3S0W1G1_9GAMM/189-287 ...............TPAWFVNL....KPEEQAYLCN........LGMESVTPEALIEDLQALLD.NLTLI.......K......rGRSH..SIwTSDLDKISV.GEIPLPNWYSELSKAKQEMIKILA.GK---..---------sgaineaittfk..
A0A222P5Z4_9GAMM/211-311 ...............TPAWFRDL....SSLMQIYLHScip.eyvvIESNEKTLEKLKFSLNQFML.KWDEI.......K.......PQH-..HL.TNDLEAIRN.NK--FPTWFTSLPRHDQQLLKLFC.DARLS..VHEIDSQL-i.............
A0A0W0WH40_9GAMM/187-285 .........apetph----IRDL....EEYQQVYFLY........LDKSLNTGEAIKIDFNTFYL.KWLEL.......I.......KEPE..LL.SQQLKMITQ.EGMN-VSWFSELSLSQQHMLCTLA.DKPID..---------eisrilkkfd....
A0A378JG11_9GAMM/192-292 ...............TPEWFRQL....PPILQILVHV........SESKPLNKESLKKDLEALET.LWKFV.......Rn.....nMEQA..NL.LQDLEIISE.DKLPKPSWFSRLSLGHQKIFSELA.SKVLK..---------eglnnienqlv...
A0A0W0WP31_9GAMM/196-295 ...............TPQWFRQL....PSEQQIYFHS........IKNLDISIRDLKFQLNNFQLtTWPAIkalyeakK.......THSA..VF.QQSLKSIRD.NV-RLPAWFTALSFEQQRFLKQLI.TA--K..S--------eelgsn........
A0A098GC21_TATMI/192-293 ...............TPDWFRRL....PSDQQLYFHS........IDNQDV-AVGLKFQLNKFKLtAWPAI.......KalyeakrQHSV..VF.QQSLQAIKE.DK-NLPSWYTSLALEQQRFVKEMV.SA-VD..LREL-----astkt.........
A0A0W0VCA5_9GAMM/215-317 ..............i-PHWFRSL....SPWMQIYLHSfip.seliSKDDLKTLTGLKRNLNSLTL.QWSSI.......K......lEQGA..NL.HHDLENIAQ.GK--IPLWMKSLNPEHQQLLKLMA.DAGLS..EAGISD---eia...........
A0A0W0XN98_9GAMM/192-288 ...............TPDWFRAL....PVQQQVYLHG........LQPTPTKLEMLKGSVNDFTI.LWNDI.......K.......KDK-..NI.DNELLKIKN.QSEVVPSWFSSLTSARREFITAVL.RSSSN..P--------sadisqaln.....
Q5ZZ81_LEGPH/192-285 ...............TPAWFKNL....PPYQQAYYCN........LNLSSVDPKKALQHFNTFFG.NWGDI.......A.......KRSL..NL.TTELNQIHT.NSPPYPSWFNELSPAQQAMIRVLS.-A--T..PHEIKSSLK..............
D3HMN4_LEGLN/189-282 ...............TPGWLRDL....EEYQHAYFCN........LDQGVTSYLEVIRDFNNFLL.NWASI.......K.......KIAL..SL.NSDLQQIVS.GSPPLPSWFNGLSVHQREMMRILA.-A--D..PTSLDKKL-t.............
#=GR D3HMN4_LEGLN/189-282 SS ...............--HHHHCS....-HHHHHHHHC........--TT--SHHHHHHHHHHHHH.HHHHH.......H.......HH-S..SH.HHHHHHHHC.T-SS--HHHHTS-HHHHHHHHHHT.-T--S..CCCHHHHH-H.............
A0A0W0U8A7_9GAMM/216-311 ...............TPDWFRRL....PLYQQAYFHG........SNTHVNSIENLALDLNKLLV.IWLKL.......K.......TTS-..SL.QEELRNIAA.GETNLPAWFRDLPANQQNLIRNLV.SPTVT..VSEVTNNLR..............
A0A0W0YZG1_LEGSP/191-287 ...............TPSWFRQS....GVVEQLYFYH........TPAYCNNSGVLRKHYEAVNF.AWMKA.......K......aERSL..II.EADLQAIRD.NR-DLPKWFTGMAPESQKFFKSWL.-----..---------lfaetqedinkgla
A0A078KW91_9GAMM/229-327 ...............TPQWFRDL....TSYQQLFFLT........IEKEEISLANLKFDTNNLIL.SWQGI.......K.......ETNSqvTL.EQDLQAIAT.GAEPLPRWFTQLSVVHRNTIRALV.SPNIS..LSKFEVRMK..............
A0A0W1AJJ5_9GAMM/192-277 ...............TPVWFRSL....QEFQKEYFVN........LEISPPNVASITSDIYKFIR.LWDEL.......K.......STSR..DI.ILELRDIDN.--------LSQFSKAQKAVLNVLA.-A--E..PWCIDANL-i.............
A0A0W0Z0R7_9GAMM/192-285 ...............TPAWFRHL....SEYQQAYFCN........LDMKKLDATTVMQDFNSFMS.VWEST.......Q.......KNSL..SL.ASDLNKIKT.HAAPYPNWFNSLNVAQQAMVRVLS.-E--D..PASFDSHL-r.............
A0A0W1A5M3_9GAMM/193-290 ...............TPQWFREL...kQEYQQVYFSN........LKIHPISPKTIRQDLNQLLL.KWKTA.......K.......TTSL..NL.LEDLNRIKN.NKTPLPLWFETFSPGQKELFRFLA.TACSS..AKEIDTEI-d.............
A0A0W0XL45_9GAMM/190-288 ..............l-PKWLDSL....PYYQQIFFLT........SPEECQTATQLNSENNAIIA.WWRKA.......T......eAKPL..SN.ADYLAIVDG.SVKKQPKWFQGIPENRRQVIRVLLiSEGNS..FERVE----grlh..........
#=GC SS_cons ...............--HHHHCS....-HHHHHHHHC........--TT--SHHHHHHHHHHHHH.HHHHH.......H.......HH-S..SH.HHHHHHHHC.T-SS--HHHHTS-HHHHHHHHHHT.-T--S..CCCHHHHH-H.............
#=GC seq_cons ...............TPtWFRpL....s.hpQhYhps........hctpshshpplptclNsFhh.tWppl.......K.......ppuh..sL.pp-LppIss.sp.slPsWFspLs.ppQphl+hLs.ps..s..stplp....t.............
//
