GenomeNet

Database: Pfam
Entry: PMAIP1
LinkDB: PMAIP1
Original site: PMAIP1 
#=GF ID   PMAIP1
#=GF AC   PF15150.7
#=GF DE   Phorbol-12-myristate-13-acetate-induced
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Hetherington K;
#=GF SE   Jackhmmer:Q13794
#=GF GA   27.00 27.00;
#=GF TC   27.70 27.60;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Phorbol-12-myristate-13-acetate-induced_protein_1
#=GF RN   [1]
#=GF RM   9704409
#=GF RT   Bcl-2-family proteins: the role of the BH3 domain in apoptosis.
#=GF RA   Kelekar A, Thompson CB;
#=GF RL   Trends Cell Biol. 1998;8:324-330.
#=GF RN   [2]
#=GF RM   10816098
#=GF RT   Role of the BH3 (Bcl-2 homology 3) domain in the regulation of
#=GF RT   apoptosis and Bcl-2-related proteins.
#=GF RA   Lutz RJ;
#=GF RL   Biochem Soc Trans. 2000;28:51-56.
#=GF DR   INTERPRO; IPR024140;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family carries a BH3 domain between residues 23 and 40.
#=GF SQ   67
#=GS Q0GKC8_DANRE/2-40         AC Q0GKC8.1
#=GS W5P738_SHEEP/1-54         AC W5P738.1
#=GS A0A3Q0G499_ALLSI/2-52     AC A0A3Q0G499.1
#=GS A0A1D5PAR2_CHICK/2-54     AC A0A1D5PAR2.1
#=GS A0A0D9S003_CHLSB/1-54     AC A0A0D9S003.1
#=GS APR_MOUSE/50-103          AC Q9JM54.1
#=GS APR_MOUSE/50-103          DR PDB; 2JM6 A; 68-93;
#=GS APR_MOUSE/50-103          DR PDB; 2NLA B; 73-93;
#=GS A0A287AZR7_PIG/17-72      AC A0A287AZR7.1
#=GS A0A2R9AKD2_PANPA/1-45     AC A0A2R9AKD2.1
#=GS A0A2K5NJZ2_CERAT/1-54     AC A0A2K5NJZ2.1
#=GS A0A3L8S875_CHLGU/2-54     AC A0A3L8S875.1
#=GS APR_HUMAN/1-54            AC Q13794.1
#=GS APR_HUMAN/1-54            DR PDB; 3MQP B; 19-43;
#=GS A0A096MPU8_PAPAN/1-54     AC A0A096MPU8.1
#=GS G1P8F9_MYOLU/1-54         AC G1P8F9.1
#=GS A0A2K5QQC6_CEBCA/1-54     AC A0A2K5QQC6.1
#=GS A0A2Y9P485_DELLE/1-54     AC A0A2Y9P485.1
#=GS A0A2K5JY52_COLAP/1-54     AC A0A2K5JY52.1
#=GS A0A2Y9K8Q6_ENHLU/1-54     AC A0A2Y9K8Q6.1
#=GS F7GW45_CALJA/1-54         AC F7GW45.1
#=GS A0A337SUX1_FELCA/1-54     AC A0A337SUX1.1
#=GS A0A452EST2_CAPHI/1-54     AC A0A452EST2.1
#=GS A0A452J430_9SAUR/1-54     AC A0A452J430.1
#=GS A0A384AXV6_BALAS/18-74    AC A0A384AXV6.1
#=GS A0A3Q1NFP6_BOVIN/1-54     AC A0A3Q1NFP6.1
#=GS A0A494BAU0_MOUSE/1-51     AC A0A494BAU0.1
#=GS H2NWG2_PONAB/1-54         AC H2NWG2.1
#=GS A0A2I2YVQ5_GORGO/1-54     AC A0A2I2YVQ5.1
#=GS A0A3Q2I0H2_HORSE/1-54     AC A0A3Q2I0H2.1
#=GS A0A2K5ZWJ0_MANLE/1-54     AC A0A2K5ZWJ0.1
#=GS A0A2R9AKC9_PANPA/1-54     AC A0A2R9AKC9.1
#=GS A0A091DM97_FUKDA/69-122   AC A0A091DM97.1
#=GS A0A494BAM9_MOUSE/1-54     AC A0A494BAM9.1
#=GS A0A2K6BV43_MACNE/1-54     AC A0A2K6BV43.1
#=GS A0A2K6KJF1_RHIBE/1-54     AC A0A2K6KJF1.1
#=GS APR_MOUSE/1-37            AC Q9JM54.1
#=GS APR_MOUSE/1-37            DR PDB; 2ROD B; 17-37;
#=GS G1LIZ7_AILME/1-54         AC G1LIZ7.1
#=GS A0A2U4BHN4_TURTR/1-54     AC A0A2U4BHN4.1
#=GS A0A2I3SX38_PANTR/1-45     AC A0A2I3SX38.1
#=GS A0A2U3XJD5_LEPWE/1-54     AC A0A2U3XJD5.1
#=GS A0A1A6G1R1_NEOLE/36-90    AC A0A1A6G1R1.1
#=GS A0A384D9A6_URSMA/155-192  AC A0A384D9A6.1
#=GS A0A2K6EM90_PROCO/1-54     AC A0A2K6EM90.1
#=GS A0A2K5VQ00_MACFA/1-54     AC A0A2K5VQ00.1
#=GS A0A1U7QLK6_MESAU/50-105   AC A0A1U7QLK6.1
#=GS A0A2Y9TJ73_PHYMC/1-54     AC A0A2Y9TJ73.1
#=GS A0A2I3HX97_NOMLE/1-53     AC A0A2I3HX97.1
#=GS A0A3Q7WCP9_URSAR/1-54     AC A0A3Q7WCP9.1
#=GS F1SMU1_PIG/66-121         AC F1SMU1.2
#=GS A0A2Y9DQZ0_TRIMA/1-54     AC A0A2Y9DQZ0.1
#=GS A0A2U3X489_ODORO/1-54     AC A0A2U3X489.1
#=GS A0A493SWX7_ANAPP/1-51     AC A0A493SWX7.1
#=GS A0A286XF37_CAVPO/49-102   AC A0A286XF37.1
#=GS G3QRM2_GORGO/1-46         AC G3QRM2.1
#=GS APR_CANLF/1-54            AC Q1PCT2.1
#=GS APR_RAT/50-105            AC Q5U777.1
#=GS H2QEL9_PANTR/1-54         AC H2QEL9.2
#=GS G3T0P7_LOXAF/1-58         AC G3T0P7.1
#=GS A0A2K6NC45_RHIRO/1-54     AC A0A2K6NC45.1
#=GS A0A452STA4_URSAM/1-54     AC A0A452STA4.1
#=GS A0A2K6S6C4_SAIBB/1-54     AC A0A2K6S6C4.1
#=GS APR_RAT/1-37              AC Q5U777.1
#=GS A0A286XF37_CAVPO/1-37     AC A0A286XF37.1
#=GS A0A3Q7SBM7_VULVU/1-54     AC A0A3Q7SBM7.1
#=GS A0A2K5CFK7_AOTNA/1-54     AC A0A2K5CFK7.1
#=GS A0A1S3A469_ERIEU/1-54     AC A0A1S3A469.1
#=GS A0A091DM97_FUKDA/26-56    AC A0A091DM97.1
#=GS L5KJZ0_PTEAL/1-54         AC L5KJZ0.1
#=GS A0A2U3Y1B4_LEPWE/1-38     AC A0A2U3Y1B4.1
Q0GKC8_DANRE/2-40                    ...akkeq-------.--..-...-------..--TAV....VECAQQLRNIGDLLNWKYKLLELIVTL-----qkiq....................
W5P738_SHEEP/1-54                    ........MPGRRAR.RS..A...QPSPTRV..PADPE....VECAIQLRRIGDKLNFRQKLVNLIAKLLRSGT........................
A0A3Q0G499_ALLSI/2-52                ........MPGRTCR.KA..A...---PQST..EREAV....RECALQLRRIGDQCHLHQKILSLIAKLFRPGT........................
A0A1D5PAR2_CHICK/2-54                ........MPGRTIR.K-..-...-PAPPAA..PAERDa..vAECALELRRIGDKADLQQKVLNLITKLFCPK-t.......................
A0A0D9S003_CHLSB/1-54                ........MPGKKAR.KN..A...QPSPTRA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
APR_MOUSE/50-103                     ........MPGKSQKsRM..R...SPSPTRV..PADLK....DECA-QLRRIGDKVNLRQKLLNLISKLFNLVT........................
#=GR APR_MOUSE/50-103          SS    ........XXXXXXXXXX..X...XXXXXXX..XTTHH....HHCH-HHHHHHHHHHHHHHCCHXXXXXXXXXX........................
A0A287AZR7_PIG/17-72                 ........MPHRSSN.KN..T...QTNPLRLalPPLPA....VKCRIGLRRVGTKLAIRQQITNFIIFFFFLG-p.......................
A0A2R9AKD2_PANPA/1-45                ........MPGKKAR.KN..A...QPSPARA..PAGP-....--------------------------------agtardqagfgigmqlrftrgkkl
A0A2K5NJZ2_CERAT/1-54                ........MPGKKAR.KN..A...QPSPMRA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
A0A3L8S875_CHLGU/2-54                ........MPGRTLR.KT..A...PP---AA..PAGREa..aVECALELTRIGDRWDLRQRLLNLLTKLFCPGT........................
APR_HUMAN/1-54                       ........MPGKKAR.KN..A...QPSPARA..PAELE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
#=GR APR_HUMAN/1-54            SS    ........XXXXXXX.XX..X...XXXXXXX..X--HH....HHHHHHHHHHHHHHHHHH---XXXXXXXXXXX........................
A0A096MPU8_PAPAN/1-54                ........MPGKKAR.KN..A...QPSPTRA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
G1P8F9_MYOLU/1-54                    ........MPGKKAR.KN..A...QPSPTRA..PAEAE....IECALQLRRIGDKLSFLQKLLNLMYKLFGSGT........................
A0A2K5QQC6_CEBCA/1-54                ........MPGKKAR.KS..A...QPSPAPA..PADLE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
A0A2Y9P485_DELLE/1-54                ........MPGRRVR.KS..A...QQSPTRA..PADPE....VECAIQFRRIGDKLNFRQKLLNLISKLFRSGT........................
A0A2K5JY52_COLAP/1-54                ........MPGKKAR.KN..A...QPSPARA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
A0A2Y9K8Q6_ENHLU/1-54                ........MPGKKAR.KS..A...QPSPARA..PADPE....MECAIQLRKFGDKLNFRQKFLNLLSKLFRSGT........................
F7GW45_CALJA/1-54                    ........MPGKKAR.KS..A...QPSPARA..PADLE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
A0A337SUX1_FELCA/1-54                ........MPGKRTR.KS..A...QPSPARA..PAEPE....VECAMQLRRFGDKLNFRQKLMNLISKLFRSGT........................
A0A452EST2_CAPHI/1-54                ........MPGRRAR.RS..A...QPSPTRV..PADPE....VECAIQLRRIGDKLNFRQKLVNLIAKLLRSGT........................
A0A452J430_9SAUR/1-54                ........MPGKTLR.KG..A...QQNPALP..AQEAV....TQCSLQLRKIGDICNLQQKILNVITKLFCPGT........................
A0A384AXV6_BALAS/18-74               ..gprrak---RSKR.NS..R...KLGTALI..PKDPE....VECAIQFRRIGDKLNFRQKLLNLISKLFRSGT........................
A0A3Q1NFP6_BOVIN/1-54                ........MPGRRAR.KS..A...QPSPTRV..PADPE....VECAIQLRRIGDKLNFRQKLVNLISKLLRSGT........................
A0A494BAU0_MOUSE/1-51                ........MPGRKAR.RN..A...PVNPTR-..-ADLK....DECA-QLRRIGDKVNLRQKLLNLISKLFNLVT........................
H2NWG2_PONAB/1-54                    ........MPGKKAR.KN..A...QPSPARA..PAELE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
A0A2I2YVQ5_GORGO/1-54                ........MPGKKAR.KN..A...QPSPARA..PAELE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
A0A3Q2I0H2_HORSE/1-54                ........MPTRKAR.KS..G...QPSPTRA..PAELE....AECAIQIRRIGDKLNFRQKLLNLIAKLFRSGT........................
A0A2K5ZWJ0_MANLE/1-54                ........MPGKKAR.KN..A...QPSPTRA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
A0A2R9AKC9_PANPA/1-54                ........MPGKKAR.KN..A...QPSPARA..PAELE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
A0A091DM97_FUKDA/69-122              ........MPGKKAR.KN..S...QQGPPRA..QAELE....VECAAQFRRIGDKLNFRQKLMNLISKLFSLIT........................
A0A494BAM9_MOUSE/1-54                ........MPGKSQKsRM..R...SPSPTRV..PADLK....DECA-QLRRIGDKVNLRQKLLNLISKLFNLVT........................
A0A2K6BV43_MACNE/1-54                ........MPGKKAR.KN..A...QPSPTRA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
A0A2K6KJF1_RHIBE/1-54                ........MPGKKAR.KN..A...QPSPARA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
APR_MOUSE/1-37                       ........MPGRKAR.RN..A...PVNPTRA..--ELP....PEFAAQLRKIGDKV------------------yct.....................
#=GR APR_MOUSE/1-37            SS    ........XXXXXXX.XX..X...XXXXXX-..-----....THHHHHHHHHHHHH------------------HHH.....................
G1LIZ7_AILME/1-54                    ........MPGKKAR.KS..A...QASPART..RGQPE....VECAIQLRRFGDKLNFRQKLLNLISKLFRSGT........................
A0A2U4BHN4_TURTR/1-54                ........MPGRRAR.KS..A...QQSPTRA..PADPE....VECAIQFRRIGDKLNFRQKLLNLISKLFCSGT........................
A0A2I3SX38_PANTR/1-45                ........MPGKKAR.KN..A...QPSPARA..PAGP-....--------------------------------agtardqagfgigmqlrftrgkkl
A0A2U3XJD5_LEPWE/1-54                ........MPGRKAR.RS..V...QPSPARA..PAETE....VECAIQLRRFGDKLNFRQKLLNLISKLFRSGT........................
A0A1A6G1R1_NEOLE/36-90               ........MPGKKAR.KSvpR...NPSPTRE..PEDLE....DECV-QLRRIGDKLNLRQKLLNFISKLFSLVT........................
A0A384D9A6_URSMA/155-192             ......sf-------.--..-...-------..-SEPE....VECAIQLRRFGDKLNFRQKLLNLISKLFRSGT........................
A0A2K6EM90_PROCO/1-54                ........MPVKKAR.KN..A...QPSPTRT..RAEIE....EECALQLRRLGDKLHFQQKLLNLIAKLFRSGT........................
A0A2K5VQ00_MACFA/1-54                ........MPGKKAR.KN..A...QPSPTRA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
A0A1U7QLK6_MESAU/50-105              ........MPGKKAR.KSvtR...IPSPTRV..PTDVE....DECVHQLRRIGDKQNLRQKLLNFISKLFSLVT........................
A0A2Y9TJ73_PHYMC/1-54                ........MPGRRAR.KS..A...QQSPTRA..PADPE....VECAIQFRRIGDKLNFRQKLLNLISKLFRSGT........................
A0A2I3HX97_NOMLE/1-53                .......k-PG-RAR.RN..A...QPSPAPA..PAELE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
A0A3Q7WCP9_URSAR/1-54                ........MPGKKAR.KS..A...QASPART..PAEPE....VECAIQLRRFGDKLNFRQKLLNLISKLFRSGT........................
F1SMU1_PIG/66-121                    ........MPGRRSR.RN..T...QTNPTRValPPDPE....VECAIQFRRIGDKLNFRQKLLNLIAKLFRLGT........................
A0A2Y9DQZ0_TRIMA/1-54                ........MPGKKAR.KI..S...QPSPTRA..LAEHE....VECAVQLRKIGDKLNFRQKLLNVISKLFCSGT........................
A0A2U3X489_ODORO/1-54                ........MPGRKAR.RS..V...QPSPALA..LAETE....VECAIQLRRFGDKLNFRQKLLNLISKLFRSGT........................
A0A493SWX7_ANAPP/1-51                ........MPCRTLR.KP..A...QPSAER-..--QAV....AECALELRRIGDKADFRQRILNLITKLFCPK-t.......................
A0A286XF37_CAVPO/49-102              ........MAGKKAR.KS..S...EPDPARA..RAELE....VECAAQLRRIGDKLNFQQKLMYLISKLISLVT........................
G3QRM2_GORGO/1-46                    ........MPGKKAR.KN..A...QPSPARA..PAGPA....--------------------------------gtardqagfgiemqlrftrgkkll
APR_CANLF/1-54                       ........MPGRKAR.KS..A...QPGPTRA..PEELE....VECAIQLRKFGDKLNFRQKLLNLLSKLFRSGT........................
APR_RAT/50-105                       ........MPGKKSR.KS..TmrrSPSPTRV..PADLK....DECD-QLRRIGDKVNLRQKLLNFISKLFNLIT........................
H2QEL9_PANTR/1-54                    ........MPGKKAR.KN..A...QPSPARA..PAELE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
G3T0P7_LOXAF/1-58                    ........MPGKKAR.KS..A...QPGPAGT..PAGTQqrdvVECAIQLRRIGDKINFRQKLLNVICKLFCSGT........................
A0A2K6NC45_RHIRO/1-54                ........MPGKKAR.KN..A...QPSPARA..QAELE....VECATQLRRFGDKLNFRQKLLNLIAKLFCSGT........................
A0A452STA4_URSAM/1-54                ........MPGKKAR.KS..A...QASPART..PAEPE....VECAIQLRRFGDKLNFRQKLLNLISKLFRSGT........................
A0A2K6S6C4_SAIBB/1-54                ........MPGKKAR.KS..A...QPSPARA..PADLE....VECAIQLRRFGDKLNFRQKLLNLISKLFCSGT........................
APR_RAT/1-37                         ........MPGRKAR.RN..A...PLNPTRA..--ELP....PEFAAQLRKIGDKV------------------yct.....................
A0A286XF37_CAVPO/1-37                ........MPGKVC-.KS..A...QPNSTR-..-AELE....VECAAQLRRVGDTLN-----------------slg.....................
A0A3Q7SBM7_VULVU/1-54                ........MPGRKAR.KG..A...QPGPTRA..PGELE....VECAIQLRKFGDKLNFRQKLLNLLSKLFRSGT........................
A0A2K5CFK7_AOTNA/1-54                ........MPGKKAR.KS..A...QPSPSRA..PADLE....VECATQLRRFGDKLNFRQKLLNLISKLFCSGT........................
A0A1S3A469_ERIEU/1-54                ........MPGKKAR.KN..A...QPLPPRV..VTEPE....VECAIQLRKIGDKLDFRQKILNLLAKFFRSGT........................
A0A091DM97_FUKDA/26-56               alfgpiyl-------.--..-...------V..PNKLE....VKCAAQLRRIGDKLN-----------------pl......................
L5KJZ0_PTEAL/1-54                    ........MPGKKAR.KN..A...QPSPPRA..PAELE....VECAIQFRRIGDKLNLRQKLLNLISKLFHSGT........................
A0A2U3Y1B4_LEPWE/1-38                ......mf-------.--..-...-------..-AKTE....VECAIQLRRFGDKLNFRQKLLNLISKLFRSGT........................
#=GC SS_cons                         ........XXXXXXX.XX..X...XXXXXX-..-TTHH....HHHHHHHHHHHHHHHHHHHCCH----------HHH.....................
#=GC seq_cons                        ........MPGKKAR.Ks..A...QPSPsRA..PA-hE....VECAhQLRRhGDKLNFRQKLLNLIuKLFpSGT........................
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