#=GF ID PRAP
#=GF AC PF15314.7
#=GF DE Proline-rich acidic protein 1, pregnancy-specific uterine
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Jackhmmer:Q96NZ9
#=GF GA 27.00 27.00;
#=GF TC 27.40 27.10;
#=GF NC 26.40 26.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 14583459
#=GF RT The proline-rich acidic protein is epigenetically regulated and
#=GF RT inhibits growth of cancer cell lines.
#=GF RA Zhang J, Wong H, Ramanan S, Cheong D, Leong A, Hooi SC;
#=GF RL Cancer Res. 2003;63:6658-6665.
#=GF RN [2]
#=GF RM 21540836
#=GF RT Recognition and suppression of transfected plasmids by protein
#=GF RT ZNF511-PRAP1, a potential molecular barrier to transgene
#=GF RT expression.
#=GF RA Qiu GH, Leung CH, Yun T, Xie X, Laban M, Hooi SC;
#=GF RL Mol Ther. 2011;19:1478-1486.
#=GF DR INTERPRO; IPR027922;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC PRAP, or proline-rich acidic protein 1, is a family of
#=GF CC eukaryotic proteins. PRAP is abundantly expressed in the
#=GF CC epithelial cells of the human liver, kidney, gastrointestinal
#=GF CC tract, and cervix. It is significantly down-regulated in
#=GF CC hepatocellular carcinoma and right colon adenocarcinoma compared
#=GF CC with the respective adjacent normal tissues. In the mouse it is
#=GF CC expressed in the epithelial cells of the mouse and rat
#=GF CC gastrointestinal tracts, and pregnant mouse uterus. This article
#=GF CC describes the isolation, distribution, and functional
#=GF CC characterization of the human homologue. PRAP was abundantly
#=GF CC expressed in the epithelial cells of the human liver, kidney,
#=GF CC gastrointestinal tract, and cervix. PRAP plays an important role
#=GF CC in maintaining normal growth suppression [1].
#=GF SQ 84
#=GS A0A2K6G772_PROCO/109-153 AC A0A2K6G772.1
#=GS A0A2K6KPF0_RHIBE/108-152 AC A0A2K6KPF0.1
#=GS A0A2U3VJH3_ODORO/101-148 AC A0A2U3VJH3.1
#=GS A0A1A6H2T1_NEOLE/88-132 AC A0A1A6H2T1.1
#=GS A0A340WY93_LIPVE/352-396 AC A0A340WY93.1
#=GS PRAP1_HUMAN/105-149 AC Q96NZ9.2
#=GS A0A093Q3L2_9PASS/8-51 AC A0A093Q3L2.1
#=GS G3W9F2_SARHA/178-221 AC G3W9F2.1
#=GS I3LXS0_ICTTR/95-139 AC I3LXS0.2
#=GS A0A2K5QYJ7_CEBCA/100-144 AC A0A2K5QYJ7.1
#=GS F7HIM7_MACMU/104-148 AC F7HIM7.2
#=GS A0A2D0QRF8_ICTPU/197-239 AC A0A2D0QRF8.1
#=GS A0A2K5BUJ4_AOTNA/108-152 AC A0A2K5BUJ4.1
#=GS H0WGU5_OTOGA/274-317 AC H0WGU5.1
#=GS PRAP1_RAT/100-144 AC Q9ES75.1
#=GS A0A2R9CJX9_PANPA/105-149 AC A0A2R9CJX9.1
#=GS A0A151MSU4_ALLMI/95-137 AC A0A151MSU4.1
#=GS F1SAB9_PIG/93-137 AC F1SAB9.3
#=GS PRAP1_MOUSE/96-144 AC Q80XD8.1
#=GS A0A1D5QMZ7_MACMU/261-305 AC A0A1D5QMZ7.1
#=GS A0A3M0KF85_HIRRU/358-398 AC A0A3M0KF85.1
#=GS A0A091W9H8_OPIHO/8-51 AC A0A091W9H8.1
#=GS A0A2K5KYR2_CERAT/106-150 AC A0A2K5KYR2.1
#=GS G3IAN5_CRIGR/99-143 AC G3IAN5.1
#=GS A0A4D9E597_9SAUR/67-110 AC A0A4D9E597.1
#=GS A0A2K6PWQ0_RHIRO/108-152 AC A0A2K6PWQ0.1
#=GS A0A091EQD7_CORBR/8-51 AC A0A091EQD7.1
#=GS A0A3M0KF85_HIRRU/323-364 AC A0A3M0KF85.1
#=GS G1L959_AILME/96-143 AC G1L959.1
#=GS F7DMF8_CALJA/100-144 AC F7DMF8.2
#=GS H7BY64_HUMAN/272-316 AC H7BY64.2
#=GS A0A226M9Z5_CALSU/75-121 AC A0A226M9Z5.1
#=GS A0A3Q0CSG9_MESAU/101-145 AC A0A3Q0CSG9.1
#=GS H0Z2I3_TAEGU/2-24 AC H0Z2I3.1
#=GS F6UTH7_HORSE/151-195 AC F6UTH7.2
#=GS A0A452RMT4_URSAM/80-127 AC A0A452RMT4.1
#=GS A0A2K6DLG7_MACNE/107-151 AC A0A2K6DLG7.1
#=GS A0A2Y9N493_DELLE/98-142 AC A0A2Y9N493.1
#=GS A0A099ZWP2_CHAVO/11-54 AC A0A099ZWP2.1
#=GS A0A087QU00_APTFO/8-51 AC A0A087QU00.1
#=GS A0A455AJX0_PHYMC/98-142 AC A0A455AJX0.1
#=GS G5AVA8_HETGA/93-137 AC G5AVA8.1
#=GS A0A0D9R2T8_CHLSB/106-150 AC A0A0D9R2T8.1
#=GS F7D505_CALJA/108-152 AC F7D505.2
#=GS A0A383ZE90_BALAS/98-142 AC A0A383ZE90.1
#=GS A0A2U3YR58_LEPWE/149-196 AC A0A2U3YR58.1
#=GS H2R0J4_PANTR/82-126 AC H2R0J4.2
#=GS A0A384BP20_URSMA/61-108 AC A0A384BP20.1
#=GS A0A3Q7TZ40_VULVU/97-141 AC A0A3Q7TZ40.1
#=GS A0A093K4Z4_STRCA/10-53 AC A0A093K4Z4.1
#=GS A0A091JTH0_EGRGA/8-51 AC A0A091JTH0.1
#=GS A0A3Q7W6P2_URSAR/101-148 AC A0A3Q7W6P2.1
#=GS U3KEX7_FICAL/1-21 AC U3KEX7.1
#=GS A0A2K6U582_SAIBB/109-153 AC A0A2K6U582.1
#=GS A0A091J622_CALAN/5-48 AC A0A091J622.1
#=GS A0A091G6S7_9AVES/10-53 AC A0A091G6S7.1
#=GS A0A2K5U5J3_MACFA/107-151 AC A0A2K5U5J3.1
#=GS A0A1D5QCU1_MACMU/102-146 AC A0A1D5QCU1.1
#=GS A0A091V4M3_NIPNI/8-51 AC A0A091V4M3.1
#=GS A0A384BP22_URSMA/99-146 AC A0A384BP22.1
#=GS A0A0Q3X2H0_AMAAE/273-316 AC A0A0Q3X2H0.1
#=GS U3KEX7_FICAL/12-55 AC U3KEX7.1
#=GS A0A2Y9FZJ5_TRIMA/131-175 AC A0A2Y9FZJ5.1
#=GS A0A096NSY9_PAPAN/106-150 AC A0A096NSY9.2
#=GS A0A3Q7TMC3_VULVU/99-143 AC A0A3Q7TMC3.1
#=GS H0Z2I3_TAEGU/15-58 AC H0Z2I3.1
#=GS G1QNY4_NOMLE/106-150 AC G1QNY4.2
#=GS E1BA00_BOVIN/96-140 AC E1BA00.1
#=GS G3QPV9_GORGO/104-148 AC G3QPV9.2
#=GS A0A1U7SX13_TARSY/100-144 AC A0A1U7SX13.1
#=GS A0A2K5QYI1_CEBCA/108-152 AC A0A2K5QYI1.1
#=GS R0LRC2_ANAPL/99-144 AC R0LRC2.1
#=GS A0A2K5BUJ2_AOTNA/100-144 AC A0A2K5BUJ2.1
#=GS A0A091E1K8_FUKDA/59-103 AC A0A091E1K8.1
#=GS A0A2K5HKW2_COLAP/99-143 AC A0A2K5HKW2.1
#=GS A0A093GGS6_DRYPU/1-48 AC A0A093GGS6.1
#=GS L9L1P4_TUPCH/250-294 AC L9L1P4.1
#=GS A0A401T4U4_CHIPU/45-88 AC A0A401T4U4.1
#=GS A0A2K6AH27_MANLE/102-146 AC A0A2K6AH27.1
#=GS H0WDU3_CAVPO/98-142 AC H0WDU3.2
#=GS M7BL41_CHEMY/95-138 AC M7BL41.1
#=GS A0A2K6U576_SAIBB/105-149 AC A0A2K6U576.1
#=GS J9P257_CANLF/100-144 AC J9P257.1
#=GS A0A2Y9MYD7_DELLE/101-145 AC A0A2Y9MYD7.1
A0A2K6G772_PROCO/109-153 .....PEPDLDDLYHPPT...VEDQGGE...GPLLWVLPPHQVLQGPEEDQDHVHH
A0A2K6KPF0_RHIBE/108-152 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVTPSRQVLRGPEEDQDHIYH
A0A2U3VJH3_ODORO/101-148 .....PEPDRDDLYHPPPeeaQEVQDEA...GLWSWALSLPQVLQGPEEDRDHIYH
A0A1A6H2T1_NEOLE/88-132 .....PELDLDSIYHPMY...EEVQDEE...IPQPWPMMYRQVLQGPEEDLDHISH
A0A340WY93_LIPVE/352-396 .....PEPDYDSLHHSWP...EEAQGEA...RPWARVLPPQQVLQGPEEDRDHIYH
PRAP1_HUMAN/105-149 .....PEPDHDSLYHPPP...EEDQGEE...RPRLWVMPNHQVLLGPEEDQDHIYH
A0A093Q3L2_9PASS/8-51 .....PEEDRDHLYHPQD...-DARKVD...VREPPRMLSLQVQNGPEEDRDHLYH
G3W9F2_SARHA/178-221 .....PEEDRDYFYHPRS...VEDDIEE...SKMLK-VSHYAVLQGPEEERDKAFH
I3LXS0_ICTTR/95-139 .....PELDLDSLYHPPV...EEVQGKE...RPWSPVLLPRQVLEGPEEDLDHIYH
A0A2K5QYJ7_CEBCA/100-144 .....PEPDYDGLYHPPP...EEDQGEE...EPQLWVMPNRQVLRGPEKDQDHIYH
F7HIM7_MACMU/104-148 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVMPNRQVLRGPEEDQDHMYH
A0A2D0QRF8_ICTPU/197-239 .....PEEDKDGLYHGDF...-TGQVFQ...VPIMENL-PKKVYMEPEEDRDHLFH
A0A2K5BUJ4_AOTNA/108-152 .....PEPDYDGLYHPPP...EEDRGEE...EPQLWVMPNRQVLQGPEEDQGHIYH
H0WGU5_OTOGA/274-317 .....PEPDHDSLYHSLT...-EDQGGT...RPWLRALPSHQVLRGPEEDRDHIYH
PRAP1_RAT/100-144 .....PELDLDSIYHPMS...EDVQNEE...VPQSRPILYRQVLHGPEEDLDHISH
A0A2R9CJX9_PANPA/105-149 .....PEPDHDSLYHPPP...EEDRGEE...RPRLWVMPNHQVLLGPEEDRDHIYH
A0A151MSU4_ALLMI/95-137 .....-EEDRDHIYHAHN...-EAEGGK...VPIEEMILLPDMVNGLEEDRDHLYH
F1SAB9_PIG/93-137 .....PEPDRDHLYHSWP...QEAQEEA...RPWARALPPRQVLQGPEEDRDHIYH
PRAP1_MOUSE/96-144 .plqgPELDLDSIDHPMS...DDVQDEE...VPQSRPILYRQVLQGPEEDLDHLAH
A0A1D5QMZ7_MACMU/261-305 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVMPNRQVLRGPEEDQDHMYH
A0A3M0KF85_HIRRU/358-398 .....---DRDHLYHPQD...-DAREAD...TYKPPRMLSLEVQNGPEEDRDHIYH
A0A091W9H8_OPIHO/8-51 .....PEEDRDHLHHPQD...-DTREAD...ARRPPWTLSREVQNGPEEDRDHLHH
A0A2K5KYR2_CERAT/106-150 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVMPNRQVLRGPEEDQDHIYH
G3IAN5_CRIGR/99-143 .....PELDLDSIHHPMY...EEVQDEE...VPQMRPMLIRQVLQGPEEDLDHISH
A0A4D9E597_9SAUR/67-110 .....PEEDRDHIYHPPD...-AALEEE...GPVQIAALYAEAFSSPEEDRDHLYH
A0A2K6PWQ0_RHIRO/108-152 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVTPNRQVLRGPEEDQDHIYH
A0A091EQD7_CORBR/8-51 .....PKEDRDHLHHPQD...-DTREAN...ARVPFWMLSLEVQNGPEEDRDHLYH
A0A3M0KF85_HIRRU/323-364 .....PEEDRDH--HPQD...-DAKEAN...ARVPLWMLAPKVQNGPEEDRDHLYH
G1L959_AILME/96-143 .....PEPDRDDLYHPPPgegEEAQEEA...GLWSRALSPPRGLQGPEEDRDHIYH
F7DMF8_CALJA/100-144 .....PEPDYDGLYHPSP...EEDQGAE...EPQLWVVPNRQVLQGPEKDQDHIYH
H7BY64_HUMAN/272-316 .....PEPDHDSLYHPPP...EEDQGEE...RPRLWVMPNHQVLLGPEEDQDHIYH
A0A226M9Z5_CALSU/75-121 ....l-EQDRDHLYHPAA...-EAEVETdtlRHRERLVLSAEVETGPEVDRDHLHH
A0A3Q0CSG9_MESAU/101-145 .....PELDLDSIYHPKY...EEVQDEE...VPLMRPMLYRQVLQGPEEDLDHIFH
H0Z2I3_TAEGU/2-24 plfpp-------------...-------...-------LPRTVQNGPEEDRDHLYH
F6UTH7_HORSE/151-195 .....PEPDYDSLYHPPP...EEAQEEA...GPRSQVLLSRQVLRGPEEDRDHIYH
A0A452RMT4_URSAM/80-127 .....PEPDRDDLYHPPPgeaEEAQEEA...GLWSWALSPPQGLQGPEEDRDHIYH
A0A2K6DLG7_MACNE/107-151 .....PEPDHDSLHHPPP...EEDQGEE...GPQLWVMPNRQVLRGPEEDQDHMYH
A0A2Y9N493_DELLE/98-142 .....PEPDHDSLHHNWP...EEAQGEA...RPWARVLPPQQVLQGPEEDRDHIYH
A0A099ZWP2_CHAVO/11-54 .....PEEDHNHLHHPED...-NAREAN...VRRPPWMLSLQVQSGPEEDRDHLHH
A0A087QU00_APTFO/8-51 .....PEEDRDHLHHPQD...-EAREAD...ARGPPRTLSLEVQSSPEEDRDHLHH
A0A455AJX0_PHYMC/98-142 .....PEPDHDSLYHNWP...EEAQGEA...RPWAQVLPPQQVLQGPEEDRDHIYH
G5AVA8_HETGA/93-137 .....PETDHDSLYHPES...EEIQVEE...EPFSWAVLSRQVLQGPEEDLDHIYH
A0A0D9R2T8_CHLSB/106-150 .....PEPDHDSLHHPPP...EEDQGEE...GPQLWVMPNRQVLRGPEEDQDHIYH
F7D505_CALJA/108-152 .....PEPDYDGLYHPSP...EEDQGAE...EPQLWVVPNRQVLQGPEKDQDHIYH
A0A383ZE90_BALAS/98-142 .....PEPDHDSLYHNWP...EEAQGEA...RPWAQVLPPQQVLQGPEEDRDHIYH
A0A2U3YR58_LEPWE/149-196 .....PEPDRDDLYHPPPeeaQEVQDEA...GLWSWALSLPQVLQGPEEDRDHIYH
H2R0J4_PANTR/82-126 .....PEPDHDSLYHPPP...EEDRGEE...RPRLWVMPNHQVLLGPEEDRDHIYH
A0A384BP20_URSMA/61-108 .....PEPDRDDLYHPPPgeaEEAQEEA...GLWSWALSPPQGLQGPEEDRDHIYH
A0A3Q7TZ40_VULVU/97-141 .....PEPDRDSLYHPPP...EEAQGPA...RLWPWVLPPQQVLQGPEEDRDHIYH
A0A093K4Z4_STRCA/10-53 .....PEEDRDHLHHPED...-NAVEDA...AHVQRPALFHNVQSGPEEDRDHIYH
A0A091JTH0_EGRGA/8-51 .....PEEDRDHLHHPQD...-DVGEAD...ASRPPWKLSLEVQNGPEEDRDHLHH
A0A3Q7W6P2_URSAR/101-148 .....PEPDRDDLYHPPPgeaEEAQEEA...GLWSWALSPPQGLQGPEEDRDHIYH
U3KEX7_FICAL/1-21 ....f-------------...-------...-----WMLALEVQNGPEEDRDHLYH
A0A2K6U582_SAIBB/109-153 .....PEPDYDGLYHPPP...EEDQGEE...EPQLWVMPNRQVLQGPEKDQDHIYH
A0A091J622_CALAN/5-48 .....PEEDRDHLYHPQD...-DGMEAG...VHGPRWMLSLEVQSSPEEDRDHVYH
A0A091G6S7_9AVES/10-53 .....PEEDRDNLHHPED...-DAKEVD...AHRALWRLVPKVQNSLEEDRDHFHH
A0A2K5U5J3_MACFA/107-151 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVMPNRQVLRGPEEDQDHMYH
A0A1D5QCU1_MACMU/102-146 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVMPNRQVLRGPEEDQDHMYH
A0A091V4M3_NIPNI/8-51 .....PEEDRDHLHHPQD...-DAREAD...ARGPPQMLSLEVQSGPEEDRDHLHH
A0A384BP22_URSMA/99-146 .....PEPDRDDLYHPPPgeaEEAQEEA...GLWSWALSPPQGLQGPEEDRDHIYH
A0A0Q3X2H0_AMAAE/273-316 .....PEQDRDHLYHSKD...-DATEAD...AQGPPLMLSLQVQNGPEEDHDHLHH
U3KEX7_FICAL/12-55 .....PEEDRDHLYHPQG...-DAREAN...APVPFWMLALEVQNGPEEDRDHLYH
A0A2Y9FZJ5_TRIMA/131-175 .....PEEDLDSLYHPPP...EEDQGVE...GPWAQALPSLQVLLGPEEDRDHIYH
A0A096NSY9_PAPAN/106-150 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVMPNRQVLRGPEEDQDHIYH
A0A3Q7TMC3_VULVU/99-143 .....PEPDRDSLYHPPP...EEAQGPA...RLWPWVLPPQQVLQGPEEDRDHIYH
H0Z2I3_TAEGU/15-58 .....PEEDRDHLYHPQD...-DAREAD...APVPFWMLAPEVQNGPEEDLDYIHH
G1QNY4_NOMLE/106-150 .....PKPDHDSLYHPPP...EEDQGKE...RPQLWVMPNRQLLLGPEEDQDHIYH
E1BA00_BOVIN/96-140 .....PEPDWDSLFHDGP...EEVLEEA...RPWARVLPPRQVLHGPEEDRDHIYH
G3QPV9_GORGO/104-148 .....PEPDHDSLYHPPP...EEDQGKE...RPRLWVMPNHRVLLGPEEDEDHIYH
A0A1U7SX13_TARSY/100-144 .....PEPDRDDLYHPPP...EEDQDEE...RPWLWAMPPRRVLRGPEEDRDHIYH
A0A2K5QYI1_CEBCA/108-152 .....PEPDYDGLYHPPP...EEDQGEE...EPQLWVMPNRQVLRGPEKDQDHIYH
R0LRC2_ANAPL/99-144 .....PEEDRDYLYHSAV..eAEAEEPA...DLGKPLVLSMEVQNGPEKDRDHLYH
A0A2K5BUJ2_AOTNA/100-144 .....PEPDYDGLYHPPP...EEDRGEE...EPQLWVMPNRQVLQGPEEDQGHIYH
A0A091E1K8_FUKDA/59-103 .....PEPDCDSLYHPAS...EEIQVKE...EPFSWAMLSRQVLQGPEEDLDHIYH
A0A2K5HKW2_COLAP/99-143 .....PEPDHDSLHHPLP...EEDQGEE...GPRLWVMPNRQVLRGPEEDQDHIYH
A0A093GGS6_DRYPU/1-48 .vqsgPEEDLDHLYHPQD...-DAREAD...ARRPPQRLQPKVRSGPEEDLDHLYH
L9L1P4_TUPCH/250-294 .....PEPDHDHLYHPLP...EEAQGEE...RHWLWAMLFHQVLQGPEKDQDHIYH
A0A401T4U4_CHIPU/45-88 .....PEEDRDMIYHSLP...DNLHHNL...QP-EMVVLRETPMNEPEEDRDMIHH
A0A2K6AH27_MANLE/102-146 .....PEPDHDSLHHPPP...EEDQGEE...GPRLWVMPNRQVLRGPEEDQDHIYH
H0WDU3_CAVPO/98-142 .....PEPDLDSLYHPAS...QEIQVKE...EPLLRAMLSRQVLRGPEKDLDHIYH
M7BL41_CHEMY/95-138 .....PEEDQDQIYHPPD...-AALEEE...GPMQTVAPYAEAISGPEEDRDHLYH
A0A2K6U576_SAIBB/105-149 .....PEPDYDGLYHPPP...EEDQGEE...EPQLWVMPNRQVLQGPEKDQDHIYH
J9P257_CANLF/100-144 .....PEPDRDSLYHPLP...EEAQGPA...RLWPWVLPPQQVLQGPEEDRDHIYH
A0A2Y9MYD7_DELLE/101-145 .....PEPDHDSLHHNWP...EEAQGEA...RPWARVLPPQQVLQGPEEDRDHIYH
#=GC seq_cons .....PEsD+DsLYHP.s...EEsQsc-...tPh.hsh.spQVLpGPEEDpDHIYH
//
