#=GF ID PTCRA
#=GF AC PF15028.7
#=GF DE Pre-T-cell antigen receptor
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Jackhmmer:Q6ISU1
#=GF GA 23.10 23.10;
#=GF TC 23.10 23.40;
#=GF NC 23.00 23.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 20944746
#=GF RT The structural basis for autonomous dimerization of the
#=GF RT pre-T-cell antigen receptor.
#=GF RA Pang SS, Berry R, Chen Z, Kjer-Nielsen L, Perugini MA, King GF,
#=GF RA Wang C, Chew SH, La Gruta NL, Williams NK, Beddoe T, Tiganis T,
#=GF RA Cowieson NP, Godfrey DI, Purcell AW, Wilce MC, McCluskey J,
#=GF RA Rossjohn J;
#=GF RL Nature. 2010;467:844-848.
#=GF RN [2]
#=GF RM 8618853
#=GF RT Cloning and comparative analysis of the human pre-T-cell
#=GF RT receptor alpha-chain gene.
#=GF RA Del Porto P, Bruno L, Mattei MG, von Boehmer H, Saint-Ruf C;
#=GF RL Proc Natl Acad Sci U S A. 1995;92:12105-12109.
#=GF DR INTERPRO; IPR027834;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The pre-T-cell antigen receptor (pre-TCR), expressed by immature
#=GF CC thymocytes, has a pivotal role in early T-cell development,
#=GF CC including TCR beta-selection, survival and proliferation of
#=GF CC CD4(-)CD8(-) double-negative thymocytes, and subsequent
#=GF CC alpha/beta T-cell lineage differentiation [1]. This protein
#=GF CC contains an immunoglobulin domain [1].
#=GF SQ 88
#=GS A0A2Y9SNH0_PHYMC/20-146 AC A0A2Y9SNH0.1
#=GS W5P264_SHEEP/20-146 AC W5P264.1
#=GS A0A287DDP6_ICTTR/26-146 AC A0A287DDP6.1
#=GS A0A452E5K8_CAPHI/27-153 AC A0A452E5K8.1
#=GS A0A2I3HI10_NOMLE/21-145 AC A0A2I3HI10.1
#=GS PTCRA_HUMAN/20-146 AC Q6ISU1.1
#=GS PTCRA_HUMAN/20-146 DR PDB; 3OF6 E; 7-110;
#=GS PTCRA_HUMAN/20-146 DR PDB; 3OF6 D; 7-110;
#=GS PTCRA_HUMAN/20-146 DR PDB; 3OF6 F; 8-110;
#=GS G3T2C6_LOXAF/20-146 AC G3T2C6.1
#=GS F6RHN4_HORSE/10-136 AC F6RHN4.2
#=GS M7BF28_CHEMY/1-109 AC M7BF28.1
#=GS A0A2I3G3P5_NOMLE/20-146 AC A0A2I3G3P5.1
#=GS A0A1S3GXF0_DIPOR/1-107 AC A0A1S3GXF0.1
#=GS A0A3M0K8U3_HIRRU/19-139 AC A0A3M0K8U3.1
#=GS A0A3Q0CUG0_MESAU/25-150 AC A0A3Q0CUG0.1
#=GS G3WD29_SARHA/20-147 AC G3WD29.1
#=GS A0A1U7UEP7_TARSY/20-146 AC A0A1U7UEP7.2
#=GS G1M299_AILME/20-142 AC G1M299.1
#=GS A0A340XA45_LIPVE/65-191 AC A0A340XA45.1
#=GS A0A2I2UHX5_FELCA/16-117 AC A0A2I2UHX5.2
#=GS A0A2U3WHI1_ODORO/40-166 AC A0A2U3WHI1.1
#=GS A0A2I2ZK87_GORGO/25-121 AC A0A2I2ZK87.1
#=GS J9P5L9_CANLF/21-147 AC J9P5L9.1
#=GS A0A0B4J2J2_PIG/40-166 AC A0A0B4J2J2.2
#=GS A0A2K6C6V6_MACNE/20-146 AC A0A2K6C6V6.1
#=GS H2PJ31_PONAB/20-146 AC H2PJ31.1
#=GS A0A0G2JV15_RAT/27-154 AC A0A0G2JV15.1
#=GS A0A3Q7RM86_VULVU/32-158 AC A0A3Q7RM86.1
#=GS A0A2K5XA65_MANLE/20-146 AC A0A2K5XA65.1
#=GS M3WBY1_FELCA/20-146 AC M3WBY1.3
#=GS G3QGA0_GORGO/20-145 AC G3QGA0.2
#=GS A0A1S3AM14_ERIEU/34-160 AC A0A1S3AM14.1
#=GS G1SKJ2_RABIT/20-146 AC G1SKJ2.2
#=GS A0A0R4J0F4_MOUSE/27-153 AC A0A0R4J0F4.1
#=GS A0A4D9DWY8_9SAUR/29-151 AC A0A4D9DWY8.1
#=GS A0A087WTE9_HUMAN/20-145 AC A0A087WTE9.1
#=GS M3YPD2_MUSPF/40-165 AC M3YPD2.1
#=GS A0A2R9BWZ0_PANPA/20-146 AC A0A2R9BWZ0.1
#=GS A0A1D5RKW3_MACMU/20-146 AC A0A1D5RKW3.1
#=GS A0A2K6NNJ1_RHIRO/25-121 AC A0A2K6NNJ1.1
#=GS A0A2K5QTM0_CEBCA/20-146 AC A0A2K5QTM0.1
#=GS L9KT05_TUPCH/20-138 AC L9KT05.1
#=GS A0A2I0LVB7_COLLI/1-106 AC A0A2I0LVB7.1
#=GS A0A0D9RGF7_CHLSB/20-146 AC A0A0D9RGF7.1
#=GS A0A452GJR9_9SAUR/19-143 AC A0A452GJR9.1
#=GS A0A2I3TJX0_PANTR/20-145 AC A0A2I3TJX0.1
#=GS A0A2Y9JF72_ENHLU/41-167 AC A0A2Y9JF72.1
#=GS A0A384C6V8_URSMA/40-162 AC A0A384C6V8.1
#=GS A0A2K5D5J3_AOTNA/20-139 AC A0A2K5D5J3.1
#=GS G1M296_AILME/31-157 AC G1M296.1
#=GS A0A2Y9DR80_TRIMA/20-146 AC A0A2Y9DR80.1
#=GS A0A2K5JQ63_COLAP/25-121 AC A0A2K5JQ63.1
#=GS A0A2K5NIX7_CERAT/25-121 AC A0A2K5NIX7.1
#=GS A0A2K6JRJ1_RHIBE/20-146 AC A0A2K6JRJ1.1
#=GS A0A096NI70_PAPAN/25-121 AC A0A096NI70.2
#=GS A0A4D9DCS3_9SAUR/23-146 AC A0A4D9DCS3.1
#=GS A0A2K6NNJ7_RHIRO/20-146 AC A0A2K6NNJ7.1
#=GS A0A2U4CIA9_TURTR/46-172 AC A0A2U4CIA9.1
#=GS PTCRA_BOVIN/31-157 AC Q0VCS0.1
#=GS A0A2K5NIX2_CERAT/20-146 AC A0A2K5NIX2.1
#=GS A0A2K5UWL8_MACFA/20-146 AC A0A2K5UWL8.1
#=GS K7F365_PELSI/23-145 AC K7F365.1
#=GS A0A493TJN1_ANAPP/16-132 AC A0A493TJN1.1
#=GS H0VKD6_CAVPO/20-143 AC H0VKD6.2
#=GS PTCRA_RAT/20-147 AC P0C6B3.1
#=GS A0A1L1S0M8_CHICK/17-139 AC A0A1L1S0M8.2
#=GS F7IFG0_CALJA/20-146 AC F7IFG0.2
#=GS A0A2Y9NR73_DELLE/31-157 AC A0A2Y9NR73.1
#=GS A0A2I3FSX3_NOMLE/26-121 AC A0A2I3FSX3.1
#=GS A0A2K5JQ45_COLAP/20-146 AC A0A2K5JQ45.1
#=GS A0A384BDV1_BALAS/31-157 AC A0A384BDV1.1
#=GS H2QT10_PANTR/25-121 AC H2QT10.2
#=GS A0A3Q0HB49_ALLSI/1-108 AC A0A3Q0HB49.1
#=GS A0A2K6JRL4_RHIBE/25-121 AC A0A2K6JRL4.1
#=GS A0A3Q7WNQ4_URSAR/20-146 AC A0A3Q7WNQ4.1
#=GS A0A2K6TB51_SAIBB/20-146 AC A0A2K6TB51.1
#=GS PTCRA_MOUSE/20-146 AC P0C6B2.1
#=GS A0A2R9BWZ6_PANPA/25-121 AC A0A2R9BWZ6.1
#=GS A0A3Q1M476_BOVIN/27-153 AC A0A3Q1M476.1
#=GS A0A2K6FZR9_PROCO/6-98 AC A0A2K6FZR9.1
#=GS A0A1A6FXY0_NEOLE/121-239 AC A0A1A6FXY0.1
#=GS H0X7H2_OTOGA/20-144 AC H0X7H2.1
#=GS J9NUS8_CANLF/21-147 AC J9NUS8.1
#=GS G1U7X8_RABIT/20-147 AC G1U7X8.2
#=GS G3WD30_SARHA/20-147 AC G3WD30.1
#=GS A0A2K6FZU1_PROCO/1-122 AC A0A2K6FZU1.1
#=GS A0A2U3XZG3_LEPWE/40-166 AC A0A2U3XZG3.1
#=GS A0A3L8SSA7_CHLGU/1-106 AC A0A3L8SSA7.1
#=GS A0A2K6FZT8_PROCO/1-124 AC A0A2K6FZT8.1
#=GS A0A2I3N8H8_PAPAN/20-146 AC A0A2I3N8H8.1
A0A2Y9SNH0_PHYMC/20-146 ...................GVGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.A.ADGT.WTSLAQLSLPSEDLAAWETLVCHTGPG.TGDHSQSTQPLQLSG..ETSSASTCLWEPLRGTRG-q...................................................
W5P264_SHEEP/20-146 ...................GVGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGFESPIWFSAGNGSSLDAFTYGPSP.A.EDGT.WTRLAQLSLHSEELAAWDTLVCHTGPG.AGDHSQSTQPLQLSG..AASSARTCLWEPLRGTRA-l...................................................
A0A287DDP6_ICTTR/26-146 ...................GVSGTPFPSLARPVTLMVDGKQQTLVICLVLDVTPPGLDSPIWFSGGNGSVLDAFTYSLSP.E.ADGT.WTSLAQLSLPSEELAAWEPLVCHTGPG.PGGQSQSTQPLQLSG..S------------------lppplcagagtl........................................
A0A452E5K8_CAPHI/27-153 ...................GVGSTPFPSLAPPITLLVDGKQQTLVICLVLDVAPPGFESPIWFSAGNGSSLDAFTYGPSP.A.EDGT.WTRLAQLSLHSEELAAWDTLVCHTGPG.AGDHSQSTQPLQLSG..ATSSARTCLWEPLRGTRA-l...................................................
A0A2I3HI10_NOMLE/21-145 ...................GVGGTLFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGFDNPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTRPG.AEGHSRSTQPLQLSG..EASTARTCPREPLS-----ape.................................................
PTCRA_HUMAN/20-146 ...................GVGGTPFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPMHLSG..EASTARTCPQEPLRGTP--gg..................................................
#=GR PTCRA_HUMAN/20-146 SS ...................XXXX--B--BEEEEEEESSSSEEEEEEEEEEEE-SSSS----EEEESSS-EE--EE---EE.E.TTSC.EEEEEEEEEETTCGGGS-SBEEEE--T.TSSS-EE---B---X..XXXXXXXXXXXXXXXXX--XX..................................................
G3T2C6_LOXAF/20-146 ...................GVGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVASPGLDSPIWFSAGNGSSLDAFTYSPSP.A.GDGT.WTSLAQLSLPSEELAAWEPLVCHTGPG.AEGSSWSTQPLQLSG..EASSARTCLWEPFWGMPAQ....................................................
F6RHN4_HORSE/10-136 ...................GVRGTPFPSLAPPITLLVDGKQQTLVVCLVLDAAPPGLESSIWFSAGNGSELDAFTYGPSL.A.EDGT.WTSLAQLSLPSEELAAWETLVCHTGPG.AGDHSRSTQPLQLSG..EASSARICLREPLRGTRG-q...................................................
M7BF28_CHEMY/1-109 ..................m----------------VVNGERKTLVVCVVNDLSQDM-ADAIWFSNQNGSALDSFTYGVSR.E.EDGT.FSTVSHLSVHTAELESWESLACHVRQN.RTAQVWSARSLLISE..DHV-EEPC-----------ldedrsvcky..........................................
A0A2I3G3P5_NOMLE/20-146 ...................GVGGTLFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGFDNPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTRPG.AEGHSRSTQPLQLSG..EASTARTCPREPLSGTPS-g...................................................
A0A1S3GXF0_DIPOR/1-107 ...................GLGVTPFPSLAPPITLQVNGEQRTLVICLVLDAAPAGLDSAVWFSAGNGSVLDAFTYGPSP.A.ADGT.WSSLAQLSVSSEKLAAWEPLVCHTRPA.PGGQSLRTQPLKLS-..-------------------....................................................
A0A3M0K8U3_HIRRU/19-139 ..................g-RAAVPLPTLTQPLSMVLAGQRRQLVVCVVSDLG-PGPGHAVWISGGNGSILQSFAYGASQ.E.DGGT.VCSV---SLLSSDPPHERELACHVGANrTSAPTHSSSPIRITG..T------------------tllpppvpalataaq.....................................
A0A3Q0CUG0_MESAU/25-150 .................pt---GIPFPSLAPPITLRVDGRRQTLVVCLVLNAAPPGLHSPIWFSAGNGSALDAFTYGPSP.A.PDGT.WTSLAQLSLPSEELEAWESVVCHTRPG.AGGQSRSTLPLQLSE..ETSTARTCFQEHLRGT---lgq.................................................
G3WD29_SARHA/20-147 ...................GMCTAPFPSMAPPLTQVVDGQQKTLVICLVLDISPSFADGSIWFSSGNGTTLDAFTYGPSP.A.GDGT.WSSLAQLSLPAEELASWEPLVCHTGPG.WQPQGPSTRPLQLSGmeKGSSSMACLT---------valrskmg............................................
A0A1U7UEP7_TARSY/20-146 ...................GVGSTPFPSLAPPITLLMDGKQQTLVVCLVLDAAPPGLDSSTWFSAGNGSVLDSFTYSPSP.A.MDGT.WTGLAQLSLPAEELAAWESLVCHTRPG.AGSHSRSTQPLQLSG..EASTARTCPQELLRGTP--gq..................................................
G1M299_AILME/20-142 ...................GVGGTPVPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSADNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPE.AGGRSQRTRPLQLSG..EASSARTCLWERLRG----....................................................
A0A340XA45_LIPVE/65-191 ...................GVGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEDLAAWETLVCHTGPG.TGDHSQSTQPLQLSG..EASSARTCLWEPLRGTRG-q...................................................
A0A2I2UHX5_FELCA/16-117 ..........alpidlisf----------------------------------PSSPASPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPG.ASDHSQSTRPLQLSG..ETSSARTCLWEPLRGTRG-q...................................................
A0A2U3WHI1_ODORO/40-166 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLQSPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSDQLAAWENLVCHTGPE.AGDRSQSTRPLQLSG..EVSSARTCLWEHLRGVRG-q...................................................
A0A2I2ZK87_GORGO/25-121 .............psspea------------------------------------ATTGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPVQLSG..EASTARTCPREPLRGTP--gg..................................................
J9P5L9_CANLF/21-147 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPE.AGDQSQSTQPLQLSG..TFSRPLTAHQSLSAGT---rgq.................................................
A0A0B4J2J2_PIG/40-166 ...................GVGSTPFPSLAPPITLLVEGKQQTLVVCLVLDVAPPGLESTIWFSAGNGSFLDAFTYGPSP.A.ADGS.WTSVAQLSVPSEELAAWETLVCHTGPG.PGNPSQSTQPLQLSG..KPSSARTCLREPLRGTRG-q...................................................
A0A2K6C6V6_MACNE/20-146 ...................GVGGTPFPSLAPPITLLADGKQQMVVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWETLVCHTGPG.AEGHSRSTQPLQLSG..EDSTARTCPWEPLRGMP--gg..................................................
H2PJ31_PONAB/20-146 ...................GVGGTPFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSTLDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRNTQPLQLSG..EASTARTCPREPLRGTP--gg..................................................
A0A0G2JV15_RAT/27-154 ...................GIAGTPFPSLAPPVTLLVDGRRHTLVVCLVLDAAPPGLDSLVWFSGGNGSALDAFTYGPSP.A.PDGT.WTSLGQLSLSSEELEAWEPLVCHTRPA.AGGLNRSTHPLQLSG.eEASTDRTCPQETLRGTQRQ....................................................
A0A3Q7RM86_VULVU/32-158 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPE.AGDQSQSTQPLQLSG..GASSARTCLWERLTGTRG-q...................................................
A0A2K5XA65_MANLE/20-146 ...................GVGGTPFPSLAPPITLLADGKQQMVVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTEPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
M3WBY1_FELCA/20-146 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPG.ASDHSQSTRPLQLSG..ETSSARTCLWEPLRGE---slt.................................................
G3QGA0_GORGO/20-145 ...................GVGGTPFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPVQLSG..EASTARTCPREPLRG----gcg.................................................
A0A1S3AM14_ERIEU/34-160 ...................GINGTPFPSLAPPITQFVDGKQQTLVVCLVLDAAPLGIDSAVWFSAGNGSALDTFTYGPSP.A.EDGT.WTSLAQLSLPQEELAAWETLVCHTGPG.AGNQSRSTQPLQLAG..RASSSRTCLWEPLIGMR--gl..................................................
G1SKJ2_RABIT/20-146 ...................GVGHTPFPSLAPPITLLVDGRRQTLVVCMVLDVAPPDPASPIWFSAGNGSAVDAFTYGPSL.A.MDGT.WTSVAQLSLPSEELASWEPLVCHTGPR.TGGRSRSTQPLQLSG..EASPARRCPQEPPRGMAAQ....................................................
A0A0R4J0F4_MOUSE/27-153 ...................GIAGTPFPSLAPPITLLVDGRQHMLVVCLVLDAAPPGLDNPVWFSAGNGSALDAFTYGPSL.A.PDGT.WTSLAQLSLPSEELEAWEPLVCHTRPG.AGGQNRSTHPLQLSG..ESSTARSCFPEPLGGTQRQ....................................................
A0A4D9DWY8_9SAUR/29-151 .................st---AVPFPTLAPPLTMVVNGERKTLVVCVVNDLSQDTAD-AIWFSNENGSALDSFTYGVSR.E.EDGT.FSTVSHLSVHTAELESWESLACHVRQN.RTAQVWSARSLLISE..DHVK-EPCL----------dedqsalpv...........................................
A0A087WTE9_HUMAN/20-145 ...................GVGGTPFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPMHLSG..EASTARTCPQEPLRG----gcg.................................................
M3YPD2_MUSPF/40-165 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLNVAPPGFGGPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPE.AGNRSQSTQPLQLSG..GDGAGAPVDAPCP------shtlw...............................................
A0A2R9BWZ0_PANPA/20-146 ...................GVGGIPFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPVQLSG..EASTARTCPQEPLRGTP--gg..................................................
A0A1D5RKW3_MACMU/20-146 ...................GVGGTPFPSLAPPITLLADGKQQMVVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A2K6NNJ1_RHIRO/25-121 .............psspea------------------------------------ATAGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A2K5QTM0_CEBCA/20-146 ...................GVSGTPFPSLAPPITLLVDGKQKMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.MDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.TEGHSRSTQPLQLSG..EASTARTCPQEPLRGMP--gr..................................................
L9KT05_TUPCH/20-138 ...................GLGSMPFPSLAPPITLLVDGKPQTLVICLVFDVAPHGFDSPIWFSAGNGSALDAFTYGPSS.A.MDGT.WTRLAQLSLPSEELTAWEPLVCHTGPR.AGGHSQSTQPLQLSG..TQGQA--------------lwlgal..............................................
A0A2I0LVB7_COLLI/1-106 ..................m----------------VVAGQLRQLVVCVVRDLAPSSS-HAVWISDGNGSALQSFAYGTSQ.E.DGGT.VC---TISLLPDEPLAEGNLACHVGPN.RTSPAHSSSPIHIMG..NEEAAELCPSS--------vavcky..............................................
A0A0D9RGF7_CHLSB/20-146 ...................GVGGTPFPSLAPPITLLADGKQQMVVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A452GJR9_9SAUR/19-143 ...................GSTAAPFPTLAPPLTMVVNGERKTLVVCVVNDLSQDTAD-AIWFSNENGSALDSFTYGVSR.E.EDGT.FSTVSHLSIHTAELESWESLACHVRQN.RTAQVWSARSLLISG..RYQAKRI------------snttdpisfls.........................................
A0A2I3TJX0_PANTR/20-145 ...................GVGGIPFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPVQLSG..EASTARTCPQEPLRG----gcg.................................................
A0A2Y9JF72_ENHLU/41-167 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGFGGPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPE.AGDRSQSTRPLQLSG..EASSARTCLWEHLRGTRG-q...................................................
A0A384C6V8_URSMA/40-162 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSADNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPK.AGDRSQSTRPLQLSG..EASSARTCLWERLR-----d...................................................
A0A2K5D5J3_AOTNA/20-139 ...................GVGGTPFPSLAPPITLLVDGKQKMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.MDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.TEGHSRSTQPLQLSG..MPG----------------ralrlgalr...........................................
G1M296_AILME/31-157 ...................GVGGTPVPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSADNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPE.AGGRSQRTRPLQLSG..EASSARTCLWERLRAL---kml.................................................
A0A2Y9DR80_TRIMA/20-146 ...................GVGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.ADGT.WTSLAQLSLPSEELAAWEPLVCHTGPG.AEGSSWSTQPLQLSG..EASSARTCLWETFRGVP--gq..................................................
A0A2K5JQ63_COLAP/25-121 .............psspea------------------------------------ATAGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A2K5NIX7_CERAT/25-121 .............psspea------------------------------------ATAGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTEPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A2K6JRJ1_RHIBE/20-146 ...................GVGGTPFPSLAPPIRLLADGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A096NI70_PAPAN/25-121 .............psspea------------------------------------ATAGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTEPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A4D9DCS3_9SAUR/23-146 .................st---AVPFPTLAPPLTMVVNGERKTLVVCVVNDLSQDTAD-AIWFSNENGSALDSFTYGVSR.E.EDGT.FSTVSHLSVHTAELESWESLACHVRQN.RTAQVWSARSLLISG..RYQAKRI------------snttdpisfls.........................................
A0A2K6NNJ7_RHIRO/20-146 ...................GVGGTPFPSLAPPIRLLADGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A2U4CIA9_TURTR/46-172 ...................GVGSTPFPSLAPPITLLVDGKQQTLVVCLVFDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.A.ADGT.WTSLAQLSLPSEDLAAWETLVCHTGPG.TGDHSQSTQPLQLSG..EASSARTCLWEPLRGTRG-q...................................................
PTCRA_BOVIN/31-157 ...................GMGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGFESPIWFSAGNGSSLDAFTYGPSP.A.EDGT.WTRLAQLSLYSEELAAWDTLVCHTGPG.AGDHGQSTQPLQLSG..DASSARTCLWEPLRGTRA-l...................................................
A0A2K5NIX2_CERAT/20-146 ...................GVGGTPFPSLAPPITLLADGKQQMVVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTEPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A2K5UWL8_MACFA/20-146 ...................GVGGTPFPSLAPPITLLADGKQQMVVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEALVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
K7F365_PELSI/23-145 .................sa---AVPFPTLAPPLTMVVNGERKTLVVCVVSDLSQD-TANAIWFSNENGSVLDSFTYGVSR.E.EDGT.FSTVSHLSVNTTDLESWESLACHVRQN.RTTQVWSARSLPISE..DH-LEEPC-----------ldedqsaqpd..........................................
A0A493TJN1_ANAPP/16-132 ................ass---GASVPTLAPPLTMVVDGQRRQLVVCVVSDV-PPGSGDAVWISSGNGSALQSFTYGASP.E.DGGT.VCAV---SILPESPPQGGLLACHVGPN.STAPARSSSPVPVTG..RVS----------------plpgsvgtgl..........................................
H0VKD6_CAVPO/20-143 ...................GAVTAAFPSLAPPVTLLVAGQRRTLVVCLVLDVAAPGPDSPVWFSAGNGSALDAFTYGPAP.G.TDGT.WTALAQLSLPAEDSAAWESLVCHAEPG.PGSPRRSTQPLRLAG..-----GVLPAPSCAGYQA-qgl.................................................
PTCRA_RAT/20-147 ...................GIAGTPFPSLAPPVTLLVDGRRHTLVVCLVLDAAPPGLDSLVWFSGGNGSALDAFTYGPSP.A.PDGT.WTSLGQLSLSSEELEAWEPLVCHTRPA.AGGLNRSTHPLQLSG.eEASTDRTCPQETLRGTQRQ....................................................
A0A1L1S0M8_CHICK/17-139 .................gg--AADPLPTLAPPLTMMVSGQWRRLVVCVVSEL-PASSGHAVWISSGNGSALQSFAYGASQ.E.EGGT.VCAVSIL---PDSPMEQELLACHVGPN.SSAPAHSSSPIAVAG..SDEEAELCPSTPAE-----praca...............................................
F7IFG0_CALJA/20-146 ...................GVGGTPFPSLAPPITLLVDGKQKMVVVCLVLDAAPSGLDSPIWFSAGNGSALDAFTYGPSP.A.MDGT.WTSLAHLSLPSEELAFWEPLVCHTGPG.TEGHSRSTQPLQLSG..EASTARTCPQEPLRGMP--gr..................................................
A0A2Y9NR73_DELLE/31-157 ...................GVGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.A.ADGT.WTSLAQLSLPSEDLAAWETLVCHTGPG.TGDHSQSTQPLQLSG..EVASARTCLWEPLRGTRG-q...................................................
A0A2I3FSX3_NOMLE/26-121 .............ssleaa-------------------------------------TTGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTRPG.AEGHSRSTQPLQLSG..EASTARTCPREPLSGTPS-g...................................................
A0A2K5JQ45_COLAP/20-146 ...................GVGGTPFPSLAPPITLLADGKQQMVVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A384BDV1_BALAS/31-157 ...................GVGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPDLESPIWFSAENGSSLDAFTYGPSP.A.ADGT.WTSLAQLSLPSEDLAAWETLVCHTGPG.TGGQSQSTQPLQLSG..EASSARTCLWEPLRGTRG-q...................................................
H2QT10_PANTR/25-121 .............psspea------------------------------------ATTGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPVQLSG..EASTARTCPQEPLRGTP--gg..................................................
A0A3Q0HB49_ALLSI/1-108 ..................m----------------VVNGERKTLVMCMVDDL-PEGTADAIWFSNENGSALDSFTYGFSQ.A.EDGT.FSAVSHLSVLTTELESWASVACHVQLN.KTTRVWSATLLPVSE..E-IMGETCP----------dedegalh............................................
A0A2K6JRL4_RHIBE/25-121 .............psspea------------------------------------ATAGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
A0A3Q7WNQ4_URSAR/20-146 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSADNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPE.AGDRSQSTRPLQLSG..EASSARTCLWERLRGLR--gq..................................................
A0A2K6TB51_SAIBB/20-146 ...................GVGGTPFPSLAPPITLLVDGKQKMMVVCLVLDVAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.MDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.TEGHSRSTQPLQLSG..EVSTARTCPQEPLRGMP--gr..................................................
PTCRA_MOUSE/20-146 ...................GIAGTPFPSLAPPITLLVDGRQHMLVVCLVLDAAPPGLDNPVWFSAGNGSALDAFTYGPSL.A.PDGT.WTSLAQLSLPSEELEAWEPLVCHTRPG.AGGQNRSTHPLQLSG..ESSTARSCFPEPLGGTQRQ....................................................
A0A2R9BWZ6_PANPA/25-121 .............psspea------------------------------------ATTGPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTNLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTQPVQLSG..EASTARTCPQEPLRGTP--gg..................................................
A0A3Q1M476_BOVIN/27-153 ...................GMGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGFESPIWFSAGNGSSLDAFTYGPSP.A.EDGT.WTRLAQLSLYSEELAAWDTLVCHTGPG.AGDHGQSTQPLQLSG..DASSARTCLWEPLRGTRA-l...................................................
A0A2K6FZR9_PROCO/6-98 ............sspevtt-------------------------------------LLSPIWFSAGNGSALDAFNYGPSP.A.TDGT.WTSLAQLSLPSEELAAWEPLVCHTGPG.--RHSRSTQPLQLSG..EDGP---------------lsgghsslsgara.......................................
A0A1A6FXY0_NEOLE/121-239 ...................GIAAIPFPSLAPPXTLLVDGRQQMLVVCLVLDAAPPGLDSPIWFSAGNGSALDAFTYGPSP.A.PDGT.WTSLAQLSLPSEELEAWESLVCHARPG.AGGQSRSTLPLQLSG..T------------------lgqflrlsvl..........................................
H0X7H2_OTOGA/20-144 ...................GVGSTPFPSLAPPITLLVDGKQQMLVVCLVLDVAPTGLDSPIWFSAGNGSALDAFTYGPSP.A.MDGT.WTRLAQLSLPSEELTAWEPLVCHTGPG.--RHSRSTQPLQLSG..EASTARTCPQESLSGMP--gq..................................................
J9NUS8_CANLF/21-147 ...................GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSEELAAWENLVCHTGPE.AGDQSQSTQPLQLSG..GASSARTCLWERVTGTRG-q...................................................
G1U7X8_RABIT/20-147 ...................GVGHTPFPSLAPPITLLVDGRRQTLVVCMVLDVAPPDPASPIWFSAGNGSAVDAFTYGPSL.A.MDGT.WTSVAQLSLPSEELASWEPLVCHTGPR.TGGRSRSTQPLQLSG.sEASPARRCPQEPPRGMAAQ....................................................
G3WD30_SARHA/20-147 ...................GMCTAPFPSMAPPLTQVVDGQQKTLVICLVLDISPSFADGSIWFSSGNGTTLDAFTYGPSP.A.GDGT.WSSLAQLSLPAEELASWEPLVCHTGPG.WQPQGPSTRPLQLSV.sQASLTFLFLPPGPYGLS--qt..................................................
A0A2K6FZU1_PROCO/1-122 ...................-VGSTPFPSLAPPITLLVDGKQQMLVVCLVLDVAPPGLHSPIWFSAGNGSALDAFNYGPSP.A.TDGT.WTSLAQLSLPSEELAAWEPLVCHTGPG.--RHSRSTQPLQLSG..EDGP---------------lsgghsslsgara.......................................
A0A2U3XZG3_LEPWE/40-166 ..................g-GGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLESPIWFSAGNGSSLDAFTYGPSP.E.ADGT.WTSLAQLSLPSDQLAAWENLVCHTGPE.AGDRSQSTRPLQLSG..EASSARTCLWERLRGMRG-q...................................................
A0A3L8SSA7_CHLGU/1-106 ..................m----------------VLAGQHRQLVVCVVSNLAPSS-GHAVWISGGNGSILQSFAYGASR.E.DGGT.VCSV---SLLSSDPPRERELACHVGAN.RTSPSHSSSPIRITG..M------------------mtllppplpalasaaq....................................
A0A2K6FZT8_PROCO/1-124 ...................-VGSTPFPSLAPPITLLVDGKQQMLVVCLVLDVAPPGLHSPIWFSAGNGSALDAFNYGPSP.A.TDGT.WTSLAQLSLPSEELAAWEPLVCHTGPG.--RHSRSTQPLQLSG..EASTARTCPKKPLRGDP--sl..................................................
A0A2I3N8H8_PAPAN/20-146 ...................GVGGTPFPSLAPPITLLADGKQQMVVVCLVLDVAPPGFDSPIWFSAGNGSALDAFTYGPSP.A.TDGT.WTSLAHLSLPSEELASWEPLVCHTGPG.AEGHSRSTEPLQLSG..EASTARTCPWEPLRGMP--gg..................................................
#=GC SS_cons ...................XXXX--B--BEEEEEEESSSSEEEEEEEEEEEE-SSSS----EEEESSS-EE--EE---EE.E.TTSC.EEEEEEEEEETTCGGGS-SBEEEE--T.TSSS-EE---B---X..XXXXXXXXXXXXXXXXX--XX..................................................
#=GC seq_cons ...................GlGuTPFPSLAPPITLLVDGKQQhLVVCLVLDVAPPGh-SPIWFSAGNGSALDAFTYGPSP.A.sDGT.WTSLApLSLPSEELAuWEsLVCHTGPG.Atu+SpSTQPLQLSG..EASoARTC..EsLRGh...t...................................................
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