#=GF ID   PTP2
#=GF AC   PF17022.9
#=GF DE   Polar tube protein 2 from Microsporidia
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   c_2006 - Hirt RP, Nakjang S
#=GF GA   27.00 27.00;
#=GF TC   31.10 61.60;
#=GF NC   22.30 19.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   24259309
#=GF RT   Reduction and expansion in microsporidian genome evolution: new
#=GF RT   insights from comparative genomics.
#=GF RA   Nakjang S, Williams TA, Heinz E, Watson AK, Foster PG, Sendra
#=GF RA   KM, Heaps SE, Hirt RP, Martin Embley T;
#=GF RL   Genome Biol Evol. 2013;5:2285-2303.
#=GF RN   [2]
#=GF RM   11159998
#=GF RT   Microsporidian invasion apparatus: identification of a novel
#=GF RT   polar tube protein and evidence for clustering of ptp1 and ptp2
#=GF RT   genes in three Encephalitozoon species.
#=GF RA   Delbac F, Peuvel I, Metenier G, Peyretaillade E, Vivares CP;
#=GF RL   Infect Immun. 2001;69:1016-1024.
#=GF DR   INTERPRO; IPR031507;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   PTP2 is a family of microsporidial polar-tube protein 2
#=GF CC   sequences. Humans can be infected with the unicellular eukaryote
#=GF CC   Microsporidia which are obligate intracellular parasites that
#=GF CC   produce resistant spores. To initiate entry into a new host cell
#=GF CC   a unique motile process is formed by a sudden extrusion of the
#=GF CC   polar tube protein from the spore [1,2]. There are a series of
#=GF CC   conserved cysteine residues.
#=GF SQ   25
#=GS L2GWZ2_VAVCU/88-284       AC L2GWZ2.1
#=GS J9DH24_EDHAE/92-292       AC J9DH24.1
#=GS A0A1Y1S7A9_9MICR/66-255   AC A0A1Y1S7A9.1
#=GS A0A059EWU7_9MICR/91-296   AC A0A059EWU7.1
#=GS L2GKU9_VITCO/65-285       AC L2GKU9.1
#=GS A0A1W0E7X7_9MICR/57-262   AC A0A1W0E7X7.1
#=GS A0A4Q9LNW7_9MICR/65-260   AC A0A4Q9LNW7.1
#=GS A0A0R0M995_9MICR/58-265   AC A0A0R0M995.1
#=GS I3EDR8_NEMP3/43-248       AC I3EDR8.1
#=GS A0A437AM83_9MICR/134-329  AC A0A437AM83.1
#=GS A0A1X0QEF9_9MICR/75-302   AC A0A1X0QEF9.1
#=GS S7WAT6_SPRLO/105-306      AC S7WAT6.1
#=GS A0A0B2UKF5_9MICR/38-248   AC A0A0B2UKF5.1
#=GS A0A0F9ZD19_9MICR/58-263   AC A0A0F9ZD19.1
#=GS T0LCE9_9MICR/41-246       AC T0LCE9.1
#=GS A9CRQ8_ENTBH/70-274       AC A9CRQ8.1
#=GS C4VAC9_NOSCE/58-263       AC C4VAC9.1
#=GS A0A059EQ21_9MICR/1-102    AC A0A059EQ21.1
#=GS R0KY97_NOSB1/54-259       AC R0KY97.1
#=GS A0A177EDG8_9MICR/59-256   AC A0A177EDG8.1
#=GS H8ZCV3_NEMS1/42-244       AC H8ZCV3.1
#=GS PTP2_ENCCU/44-250         AC Q8SRT0.1
#=GS R0MC83_NOSB1/54-132       AC R0MC83.1
#=GS L7JVD6_TRAHO/88-284       AC L7JVD6.1
#=GS A0A4Q9KYG2_9MICR/65-260   AC A0A4Q9KYG2.1
L2GWZ2_VAVCU/88-284                  ....................C.DNRGVDGN---------.....WNLINKQLQEECVKQKKE...KKERAEQLAKELT----------...QPTQDDC.KIRISKESMVCHARKVMNNVIKDAYYTIKLF.GNVVEIIV..KNQPV.FMGVTERFKY..NAKRLKKQAS.NAFKNSPTATFKFNRLGGLLSQTGEVPQPK..KNNPCAACLEMLKEKTN..SVEGQ..ANNC.-GGCD..SMLDITT.I.HNGQFRIQNKDENTTDSK.................
J9DH24_EDHAE/92-292                  ....................CeNNKGIDGN---------.....MQQLKEEQKQKCIEEAQK...KRELIENLVNNNI----------...-SQQKDC.VVKASKKTMICHTKKVISDMINTPYYVLQNN.GNVFTLEI..DNEKV.AMAVKEGIKY..CYEELEKPQ-.HAELAKPNQSVKFNKLGQVLSKEGLPPKSAamEKNPCANCLSMLNNKAK.rSVEGV..PDEC.ERTCEdgQLSGLED.L.TNSTFFTKSN--KK----gdina............
A0A1Y1S7A9_9MICR/66-255              .............epdpiel-.-----------------.....---------ANCVAEKKK...RLVKVASNVEQLIRTEMSK----...-PMPKTC.VQKLDQRSKNCYTKAALDDWLRNAKYNMNVF.SNVAEISN..ADGIVlLMLVYEEPRY..TVILPEKLC-.KSFFKRPGYSVKVNSAGDLVAAEGKPNEKPksKALNCRPCSDFMQ----..TTEGK..YADC.DNTCD..PMYSLLS.TrDSFSTKNLNEKAKK----pva..............
A0A059EWU7_9MICR/91-296              ..........aneflsgnpeC.NQQAVEGN---------.....WKVINEKIKQECRNKVNE...RKAKAEQIAKFIT----------...KPTPDKC.VKKLNPNALVCQALTVMNTIIKQPRFKIDLYgSNVVEIKK..DGSPI.LLGVAESLNY..NVTKMKRKR-.YNPLKNPTARLEFNELGSLLKQEGEIPKPK..KLDPCGSCLEKLSKKA-..QVEGE..KDMC.-GGCD..ALMELNS.L.KRGSFNNLQTENKKPE--vt...............
L2GKU9_VITCO/65-285                  ................cgar-.DNRLSEGVYIPQADPVT.....EHLERIQKQQQCLVAKAK...TQKAIEDTMKRVIKETTKQATNDfqkNLEKKNC.VNKLDRSNHECFVKDVLKDFYTAIVWKVAVH.DNVAQLWY..HDKLV.IMIIFETIDY..IVKPEEQEC-.FTFFPTSNVAAEENALGHVVNVIGKPATPKsaTQGECRPCTDFLKK---..TVEGT..ASKC.TNNCD..PSNILFS.G.SNFKTKKRNTSTVAPSE-a................
A0A1W0E7X7_9MICR/57-262              ..............cqqsli-.-----EKN--VQVDGAQ.....-QKVDPSEFTACVEAKKK...KLFQLSKSINSLIKNEMSK----...-PIQKPC.VVKLNQATKNCYTKAALKEWLKGSKYSLDVF.KNVVEIWNteKEKLI.AMIVHETPKY..ELILPPKVC-.KSFFKRPSYKMDVNRAGDMINSQGKPNEKK.dIAKDCRPCSDFAN----..TTEGA..FAEC.KNTCD..PMSMIVN.V.SDSIH-------------tvhrpttlpsgk.....
A0A4Q9LNW7_9MICR/65-260              ....................C.DPRGVEGN---------.....WQLVSQKLKQECIAKSQE...RSDRAIKLAKQLT----------...QPKPQDC.TVRISKGSMACHARKVLKDVITSPYYTLNMY.GNVVEVMV..GDEVV.MMAVAENVYY..DITHKSHER-.PRALKRPTASLEFNQLGGLLSQKGELPKPK..KEDPCAACLEYLSKQTT..AIEGQ..SENC.-GGCD..SMMEITS.V.RSDSFRNVTKPNGQ----ssst.............
A0A0R0M995_9MICR/58-265              pgtmagqmqqnacsgqsvea-.----------------N.....LAQVNQSLANKCIAEKKE...KRLQLAEAAKTLL----------...-NEKDVC.VQKVSPQAMNCHVKAEVRKIIAEPFYTLKKY.GNVAEVFE..QGQPI.MLTITENFGY..IAEAKDQKKT.SPFNKSDQVSFKYNRLGGLLSQSGELPQPK..KDNPCSACLEAMTKKAE..SVDGQ..TENC.-GGCD..SSYSPAS.V.QVGQFKMQSSDKKGSDD-s................
I3EDR8_NEMP3/43-248                  ....................C.APGFLKGTSILGSMGVNgmggvANGIRINAPTLCVKQAPE...PTEVLK--MSPILKKLAQQQAVQailNLQDSECkIGKVNPKTQACFLFKTIRAKAQAPVTAITTT.GNALFLKN..KDKVS.TMIVIEKFGE..LTPQKKKPITlEQLVGRPISSTTFNEFDDILKREGNPVSRT..KKNKCAACLKDLKENIS.lGGDME..CDIC.S----..-------.-.------------------dsismpldfs.......
A0A437AM83_9MICR/134-329             .................cgk-.--SSVEGN---------.....WKAINNKIKEECIAKVQE...RKNKAEEIAKLLT----------...KPDTKSC.VKKLNPNSLVCQAKNVMENIIKAPKYKINLYgDNVVVVKK..EGQPI.LMGIAENIHY.dVTKINKKYI-.-SALRKPTAQLEFNELGSLLKQEGEIPKPK..KLDPCGSCLEFLSKKSQ..-TEGE..KDDC.-GGCD..SFMELTN.V.KNASFKNLNGNGN-----gngsn............
A0A1X0QEF9_9MICR/75-302              ckklastgtsvegvtvgysp-.-----------------.....-AAFDQGHYNDCIAQRTK...DTKEMLKKLVKSFEQIVRDSNTP...KPMTKSC.TYKLDFASLECYQQNKMNEIMTAKEWKLIVV.ENVIQLWY..KNTLA.AMAIMENIRY..EILDFLEKC-.ASSFRTKTNSVTFNKFGEAMTSEGAIRSSK..NPNNCVPCSEYYNKRDKrvSVDGH..YSNC.SASCD..MMSKF--.V.AYNTFPEQRKIT------knrllvknkkekkantd
S7WAT6_SPRLO/105-306                 ....................C.AGLTIEGK---------.....AAELKQEQVKQCFLQKQE...KKKTAQAIANKIIET--------...PKQNKEC.IVKYDAKAGACNAEKVMGNIIGEPYYRLKVHgGNVVVLNI..KGRDV.LMAVVETISY..RVKPKEKEAQ.SCFKDNAGAEYTFNVLGNLLEKRGELPKPVqkEDDDCTECIQKLAKKAI..AIEGK..LTAC.-GGCD..NSSTLVG.M.TKGNFKTDNKSKKNDDD-s................
A0A0B2UKF5_9MICR/38-248              .qqgtimqgsrrgsqcailg-.-----------------.....------EGVSDCAKELQK...KQEEKERNAQIAASIQYHQTMN-...EKAENKC.IKPTLNGSDVCAEQEFLKQAATNGKYTISTK.DNVVMLKE..NDLVI.GLAVHDRMTT..VPVKEKAREPdPLTGKKETREVKLNQFGQVVGLSGPPSKP-..-KDDCV-CPNKTGKSGK.vTFEMA..TRSC.ADACA..SKNIMYDaM.VQNNSSEDEADTSK----psee.............
A0A0F9ZD19_9MICR/58-263              ....................C.TTEFINGKKIINNNINK.....---------EECQRRAYE...KGQQQQHAAINAAVQAMKMVAKL...PPKKQEC.IRTVSNASQECLKNKIKKRSQTKPRYIVASN.SNKTVIFD..GKKIV.FIGLRTQSHY..TLRHNKGRP-.FKVVTDYPFVVVFNEYGEAIASKTPIS---..KKKPYCICPGINDAISQ.pTREGL..LSDCiKQECS..GNGIITN.I.LSNATVDVSNDGEGAKS-s................
T0LCE9_9MICR/41-246                  ....................C.QIRYINGKRICPENTKS.....--------PEECMQEAQM...KAERRKQELANVAMEAVKAAAKR...PEKPEEC.IKTVDPKEQQCLVKKLQEKAKKKPKYVVSNN.SNEVRIFN..GNDLI.FIAMRIQSHY..-AKHEPKKAI.PSTVKNYDNAIMFNEAGDVVATKTKKNKP-..---KPQDCICPTPSEPP.vTKEGL..LSECfKPTCK..TAGILSE.I.VSNSTVTNVKDDQKDDK-d................
A9CRQ8_ENTBH/70-274                  ...................q-.NNQTIEGRPLVTFDPVE.....--------IQKCIAEKKE...KLSKIATSIKQLISKEMSKPSSS...SSSSKPC.VTKLDQKSKACYTKTALQQWIKDPRFSVDVH.NNEAEIWE..GDTLL.MMIVHESPKY..VIMKPPKIC-.RTFFKKPNYKMDINRAGDMITSEGKPNQKK.pQELNCKPCSDFLN----..TTEGK..FANC.DNSCS..PINILTS.V.KDTITEENSKVIDKKLT-k................
C4VAC9_NOSCE/58-263                  ....................C.TTEFINGKKIINNNINK.....---------EECQRRAYE...KGQQQQHAAINAAVQAMKMVAKL...PPKKQEC.IRTVSNASQECLKNKIKKRSQTKPRYIVASN.SNKTVIFD..GKKIV.FIGLRTQSHY..TLRHNKGRP-.FKVVTDYPFVVVFNEYGEAIASKTPIS---..KKKPYCICPGINDAISQ.pTREGL..LSDCiKQECS..GNGIITN.I.LSNATVDVSNDGEGAKS-s................
A0A059EQ21_9MICR/1-102               ...................g-.-----------------.....------------------...-----------------------...-------.-------------------------------.--------..-----.---VAESLNY..NVTKMKRKR-.YNPLKNPTARLEFNELGSLLKQEGEIPKPK..RLDPCGSCLEKLSKKA-..QVEGE..KDMC.-GGCD..ALMELNS.L.KRGSFNNLQTENKKPE--vt...............
R0KY97_NOSB1/54-259                  ....................C.NIQYINGKKIIPANNNN.....--------PAECQRDLIE...RAKMRQAQAIETAARAVQTIEHI...-KQEPKC.VKSVDLRETQCIKTKLLNELKNEPEYTVTGE.ENKVNVFK..KGKKI.MLAANIQHHF..-IKVEKPPSEqFQIVKKAKEAYVFNAIGEVLSTKQT-----..RKRPAPQCICPGKSTPQ..TAEGTplINECkQAECK..NYDLFVN.I.LSNTTVSEPGPEEKKAKK.................
A0A177EDG8_9MICR/59-256              ...............agslg-.------GMSIGGAGGIR.....-GNFNFNTPSVCIKPLQQphqTPEAVEAARNPAFRKAANLIAMRslsSLQNADCnQNAVNVKSQVCWLLKHFSKKSAEPQVVIGST.KNALTVMN..KDQPD.ALLVVEVLGK..PTPQKKDDPAtQDLVKKFTRKTVINSYDDILKKDKDPK--K..KNADCAKCLESLKTNI-..SSDSE..CD-C.----Q..N------.-.------------------nlsfsmgdf........
H8ZCV3_NEMS1/42-244                  ....................C.SSQFMKGTNVLGSMGINgmggiGNAFQVGMPSICLREGKD...DPNQVK--MHPLVKKLTRMKAVDsllNLDDTNCtIGKVSSKSQICHLFKLIKRKTNTPEKAVSII.ANTVSLED..TKGVS.AMFLYEPFGI..LDKKKKKKRTiAEIIGPANSNTTLNEFDDILKRNGGRAAR-..KRSKCEECLKSLKNDLA..TTDLE..CDPC.-----..-------.-.------------------getinipfgm.......
PTP2_ENCCU/44-250                    ....................C.TSKKLEGAEIMRRNMIE.....-----------CQKRSSE...ATKAMIERANEKAVESFNKEVSKgpsQKDGGQC.IEKAVQGTDRCILAGIIDKAVNKRKYRISDV.ENSTSLYR..GDKLI.ALIVNVDYGLqpITKPKKKKSKiMANLPQPKREMYFNQIGQLVGARGTFPQE-..NKEDCKPCEGPKK----..TVETT..SEKC.NLGCElkGTSAL--.I.SKAIQKKEVKDTKEGEK-s................
R0MC83_NOSB1/54-132                  ....................C.NIQYINGKKIIPANNNN.....--------PAECQRDLIE...RAKMRQAQAIETAARAVQTIEHI...-KQEPKC.VKSVDLRETQCIKTKLLNELK----------.--------..-----.----------..----------.------------------------------..-----------------..-----..----.-----..-------.-.------------------k................
L7JVD6_TRAHO/88-284                  ....................C.DPRGVDGN---------.....WNLINKQLQEECIKQKRE...KKERAEQLAKELT----------...QPSQDDC.KIRISKESMVCHARKVMNNVIKDAYYTIKLF.GNVVEIIV..KNQPV.FMGVTERFRY..NAKRLKKQAP.NAFKNSPTATFKFNRLGGLLSQTGEVPQPK..KNNPCAACLEMLKEKTN..SVEGQ..ANNC.-GGCD..SMLDITT.I.HNGQFRIQNKEENTTDSK.................
A0A4Q9KYG2_9MICR/65-260              ....................C.DPRGVEGN---------.....WQLVSQKLKQECIAKSQE...RNDRAVKLAKQLT----------...QPKPQDC.TVRISKGSMACHARKVLKDVITSPYYTLNMY.GNVVEVMV..GDEVV.MMAVAENVYY..DITHKSHER-.PRALKRPTASLEFNQLGGLLSQKGELPKPK..KEDPCAACLEYLSKQTT..AIEGQ..SENC.-GGCD..SMMEITS.V.RSDSFRNVTKPNGQ----ssst.............
#=GC seq_cons                        ....................C.s.phlpGp...............t..p.t..pcClpctpE...+tcphpphspplh.p.hp..........pppcC.lt+lstpottChtpclhpchhppPhYslssh.sNslplhp..psphl.hhsVtEshpY...spppc+cp...shhcpsstshpFNchGsllspcGchsp.t..+pssCssClchhspps...osEGp..hspC..ssC-..sh..lss.l.pssphhp.sp.tpt....s................
//