GenomeNet

Database: Pfam
Entry: PTPLA
LinkDB: PTPLA
Original site: PTPLA 
#=GF ID   PTPLA
#=GF AC   PF04387.16
#=GF DE   Protein tyrosine phosphatase-like protein, PTPLA
#=GF AU   Mifsud W;0000-0002-9805-6461
#=GF SE   Pfam-B_1525 (release 7.3)
#=GF GA   21.20 21.20;
#=GF TC   21.30 21.30;
#=GF NC   20.80 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Protein_tyrosine_phosphatase
#=GF RN   [1]
#=GF RM   10644438
#=GF RT   Molecular cloning, chromosomal mapping, and developmental
#=GF RT   expression of a novel protein tyrosine phosphatase-like gene. 
#=GF RA   Uwanogho DA, Hardcastle Z, Balogh P, Mirza G, Thornburg KL,
#=GF RA   Ragoussis J, Sharpe PT; 
#=GF RL   Genomics 1999;62:406-416.
#=GF RN   [2]
#=GF RM   11054553
#=GF RT   Human protein tyrosine phosphatase-like gene: expression
#=GF RT   profile, genomic structure, and mutation analysis in families
#=GF RT   with ARVD. 
#=GF RA   Li D, Gonzalez O, Bachinski LL, Roberts R; 
#=GF RL   Gene 2000;256:237-243.
#=GF DR   INTERPRO; IPR007482;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family includes the mammalian protein tyrosine
#=GF CC   phosphatase-like protein, PTPLA. A significant variation of
#=GF CC   PTPLA from other protein tyrosine phosphatases is the presence
#=GF CC   of proline instead of catalytic arginine at the active site. It
#=GF CC   is thought that PTPLA proteins have a role in the development,
#=GF CC   differentiation, and maintenance of a number of tissue types
#=GF CC   [1].
#=GF SQ   3450
#=GS D7SKL3_VITVI/52-201         AC D7SKL3.1
#=GS F1P9L8_CANLF/64-223         AC F1P9L8.3
#=GS A0A0E0HQP6_ORYNI/1-158      AC A0A0E0HQP6.1
#=GS A0A446P7G3_TRITD/51-216     AC A0A446P7G3.1
#=GS A0A2B4T136_STYPI/328-489    AC A0A2B4T136.1
#=GS A0A401NHR0_SCYTO/78-239     AC A0A401NHR0.1
#=GS A0A137QUE1_9AGAR/108-266    AC A0A137QUE1.1
#=GS R4GIV6_CHICK/77-238         AC R4GIV6.1
#=GS A0A0L0D1Y2_THETB/36-189     AC A0A0L0D1Y2.1
#=GS J4GDZ6_9APHY/388-561        AC J4GDZ6.1
#=GS A0A3Q0EMB3_VIGRR/3-118      AC A0A3Q0EMB3.1
#=GS A0A093IZD4_DRYPU/47-208     AC A0A093IZD4.1
#=GS A0A2K6TCU7_SAIBB/140-301    AC A0A2K6TCU7.1
#=GS A0A6G0URE0_9BILA/714-875    AC A0A6G0URE0.1
#=GS A0A2K5LH28_CERAT/195-356    AC A0A2K5LH28.1
#=GS A0A3S3QAC7_9MAGN/49-208     AC A0A3S3QAC7.1
#=GS F7D3J3_ORNAN/93-254         AC F7D3J3.2
#=GS A0A446WNI9_TRITD/56-218     AC A0A446WNI9.1
#=GS A0A453DZ82_AEGTS/1-49       AC A0A453DZ82.1
#=GS A0A2K5JNP0_COLAP/233-394    AC A0A2K5JNP0.1
#=GS A0A0S7DPW4_9EURO/48-195     AC A0A0S7DPW4.1
#=GS H2M1B1_ORYLA/73-217         AC H2M1B1.2
#=GS A0A395S7M0_9HYPO/66-214     AC A0A395S7M0.1
#=GS A0A0E0MRE0_ORYRU/132-205    AC A0A0E0MRE0.1
#=GS A0A0E0HQQ0_ORYNI/2-90       AC A0A0E0HQQ0.1
#=GS A0A0K9R0N7_SPIOL/52-210     AC A0A0K9R0N7.1
#=GS A0A485KQR1_9STRA/54-214     AC A0A485KQR1.1
#=GS A0A226PNE8_COLVI/43-200     AC A0A226PNE8.1
#=GS A0A6G0HKK9_LARCR/73-234     AC A0A6G0HKK9.1
#=GS F0ZV62_DICPU/29-191         AC F0ZV62.1
#=GS A0A383YT91_BALAS/195-356    AC A0A383YT91.1
#=GS A0A3P7LH21_DIBLA/17-80      AC A0A3P7LH21.1
#=GS A0A0F9XM22_TRIHA/65-219     AC A0A0F9XM22.1
#=GS A0A2A9N9T8_9AGAR/67-219     AC A0A2A9N9T8.1
#=GS A0A453GW82_AEGTS/1-72       AC A0A453GW82.1
#=GS D3ZHG0_RAT/85-246           AC D3ZHG0.3
#=GS A0A1E4RTD6_9ASCO/63-216     AC A0A1E4RTD6.1
#=GS A0A1J8Q1F2_9AGAM/48-201     AC A0A1J8Q1F2.1
#=GS A0A091R0F1_9GRUI/1-121      AC A0A091R0F1.1
#=GS A0A671UL36_SPAAU/147-307    AC A0A671UL36.1
#=GS A0A068Y7P9_ECHMU/47-209     AC A0A068Y7P9.1
#=GS A0A1G4BBF0_9PEZI/67-215     AC A0A1G4BBF0.1
#=GS A0A074YEJ8_AURSE/67-217     AC A0A074YEJ8.1
#=GS J9P6B7_CANLF/80-241         AC J9P6B7.1
#=GS A0A6I8PHZ0_ORNAN/87-248     AC A0A6I8PHZ0.1
#=GS A0A287G688_HORVV/89-248     AC A0A287G688.1
#=GS A0A0D3EJM4_9ORYZ/272-315    AC A0A0D3EJM4.1
#=GS A0A1G4J0W8_9SACH/53-206     AC A0A1G4J0W8.1
#=GS A0A168L7N9_MUCCL/36-185     AC A0A168L7N9.1
#=GS A0A3Q1EPD8_9TELE/190-351    AC A0A3Q1EPD8.1
#=GS A0A368F0X7_ANCCA/48-153     AC A0A368F0X7.1
#=GS A0A402EUJ5_9SAUR/38-199     AC A0A402EUJ5.1
#=GS A0A397UD29_9GLOM/58-206     AC A0A397UD29.1
#=GS A0A0B0NMU6_GOSAR/52-211     AC A0A0B0NMU6.1
#=GS A0A4P1R0S9_LUPAN/11-179     AC A0A4P1R0S9.1
#=GS A0A0A0APL5_CHAVO/33-194     AC A0A0A0APL5.1
#=GS A0A2K6JS20_RHIBE/65-224     AC A0A2K6JS20.1
#=GS A0A0L7K1S0_9NEOP/27-115     AC A0A0L7K1S0.1
#=GS G5AV91_HETGA/66-208         AC G5AV91.1
#=GS A0A0E0MRD6_ORYRU/110-219    AC A0A0E0MRD6.1
#=GS A0A507BVQ5_9FUNG/63-213     AC A0A507BVQ5.1
#=GS A8N6T0_COPC7/117-280        AC A8N6T0.1
#=GS A0A2I3GAQ0_NOMLE/65-224     AC A0A2I3GAQ0.1
#=GS A0A2G9RZE0_LITCT/50-147     AC A0A2G9RZE0.1
#=GS A0A2S4L1Y8_9HYPO/62-210     AC A0A2S4L1Y8.1
#=GS A0A6I8ULI2_DROPS/197-359    AC A0A6I8ULI2.1
#=GS Q0U5J4_PHANO/49-198         AC Q0U5J4.2
#=GS A0A1Y2D6G3_9PEZI/55-208     AC A0A1Y2D6G3.1
#=GS A0A452RNQ5_URSAM/28-166     AC A0A452RNQ5.1
#=GS A0A2K6CZB8_MACNE/195-356    AC A0A2K6CZB8.1
#=GS A0A091NPY6_9PASS/33-192     AC A0A091NPY6.1
#=GS G2X2V7_VERDV/63-211         AC G2X2V7.1
#=GS A0A453GXA7_AEGTS/100-186    AC A0A453GXA7.1
#=GS H2R8B8_PANTR/197-358        AC H2R8B8.2
#=GS A0A2Y9N9A6_DELLE/65-224     AC A0A2Y9N9A6.1
#=GS A0A2H3H5P2_FUSOX/23-171     AC A0A2H3H5P2.1
#=GS A0A1R3HRH0_9ROSI/21-90      AC A0A1R3HRH0.1
#=GS A0A4S2L2P9_OPIFE/54-214     AC A0A4S2L2P9.1
#=GS A0A1Q3E9Y7_LENED/127-199    AC A0A1Q3E9Y7.1
#=GS A0A0D2XP61_FUSO4/58-208     AC A0A0D2XP61.1
#=GS A0A4S4N2R6_9APHY/122-270    AC A0A4S4N2R6.1
#=GS N4U2G8_FUSC1/58-208         AC N4U2G8.1
#=GS A0A0D9NUP8_METAN/62-210     AC A0A0D9NUP8.1
#=GS A0A314L9Q7_NICAT/39-225     AC A0A314L9Q7.1
#=GS K3XAL3_GLOUD/63-223         AC K3XAL3.1
#=GS A0A663E0F8_AQUCH/78-239     AC A0A663E0F8.1
#=GS A0A4Q4WBJ3_9PEZI/66-216     AC A0A4Q4WBJ3.1
#=GS B8ADB1_ORYSI/59-221         AC B8ADB1.1
#=GS A0A2K5PPP1_CEBCA/65-224     AC A0A2K5PPP1.1
#=GS A0A1L9PAQ2_ASPVE/72-230     AC A0A1L9PAQ2.1
#=GS A0A1Z5JA56_FISSO/377-505    AC A0A1Z5JA56.1
#=GS A0A668AF70_9TELE/71-232     AC A0A668AF70.1
#=GS L8H6I1_ACACA/74-221         AC L8H6I1.1
#=GS A0A2R9AV26_PANPA/61-217     AC A0A2R9AV26.1
#=GS W5JQ23_ANODA/58-219         AC W5JQ23.1
#=GS A0A0V1CCW4_TRIBR/491-657    AC A0A0V1CCW4.1
#=GS A0A250X301_9CHLO/53-228     AC A0A250X301.1
#=GS A0A1X2IM91_9FUNG/67-216     AC A0A1X2IM91.1
#=GS A0A317WRG0_9EURO/77-267     AC A0A317WRG0.1
#=GS A0A565CK41_9BRAS/42-194     AC A0A565CK41.1
#=GS A0A1A5ZY16_9TREE/321-515    AC A0A1A5ZY16.1
#=GS A0A453DZK9_AEGTS/1-103      AC A0A453DZK9.1
#=GS A0A139HW51_9PEZI/523-673    AC A0A139HW51.1
#=GS HACD2_BOVIN/85-246          AC Q2KIP8.2
#=GS A0A3Q0IR25_DIACI/17-176     AC A0A3Q0IR25.1
#=GS A5DKV8_PICGU/62-213         AC A5DKV8.1
#=GS A0A2K5KKE6_CERAT/65-224     AC A0A2K5KKE6.1
#=GS H0ZFU3_TAEGU/259-420        AC H0ZFU3.2
#=GS A0A3P9AVM2_9CICH/73-234     AC A0A3P9AVM2.1
#=GS V2XB91_MONRO/49-197         AC V2XB91.1
#=GS A0A0N4YZ31_NIPBR/55-117     AC A0A0N4YZ31.1
#=GS F4P199_BATDJ/62-211         AC F4P199.1
#=GS D6WKW4_TRICA/65-226         AC D6WKW4.1
#=GS A0A4S4KL35_9AGAM/325-455    AC A0A4S4KL35.1
#=GS A0A1E4T2P7_9ASCO/84-209     AC A0A1E4T2P7.1
#=GS A0A5C6NUA1_9TELE/233-323    AC A0A5C6NUA1.1
#=GS A0A3Q2VKR6_HAPBU/190-351    AC A0A3Q2VKR6.1
#=GS A0A194PJW8_PAPXU/65-226     AC A0A194PJW8.1
#=GS A0A452G630_CAPHI/119-280    AC A0A452G630.1
#=GS A0A5G2QHW1_PIG/140-301      AC A0A5G2QHW1.1
#=GS A0A0C3AQ10_9AGAM/45-198     AC A0A0C3AQ10.1
#=GS F1PL37_CANLF/122-283        AC F1PL37.3
#=GS A0A2K6PGF9_RHIRO/3-153      AC A0A2K6PGF9.1
#=GS L0AVB2_THEEQ/70-227         AC L0AVB2.1
#=GS A0A091PXD2_LEPDC/33-194     AC A0A091PXD2.1
#=GS A0A5N4EJD7_CAMDR/2-134      AC A0A5N4EJD7.1
#=GS A0A1B6Q1T2_SORBI/67-182     AC A0A1B6Q1T2.1
#=GS A0A446P7I7_TRITD/39-201     AC A0A446P7I7.1
#=GS M2W6W9_GALSU/51-212         AC M2W6W9.1
#=GS A0A094LJ82_PODCR/152-306    AC A0A094LJ82.1
#=GS A0A091MKS1_9PASS/1-137      AC A0A091MKS1.1
#=GS A0A1E4TJ78_9ASCO/45-198     AC A0A1E4TJ78.1
#=GS A8BKZ7_GIAIC/43-196         AC A8BKZ7.1
#=GS A0A074RPG6_9AGAM/101-252    AC A0A074RPG6.1
#=GS A0A3M7MA38_9PLEO/159-311    AC A0A3M7MA38.1
#=GS A0A3Q2VEQ3_HAPBU/75-236     AC A0A3Q2VEQ3.1
#=GS A0A4S2MAZ7_OPIFE/219-380    AC A0A4S2MAZ7.1
#=GS A0A2G7FYQ0_9EURO/1-141      AC A0A2G7FYQ0.1
#=GS A0A401L109_ASPAW/50-211     AC A0A401L109.1
#=GS A0A565CX29_9BRAS/85-237     AC A0A565CX29.1
#=GS A0A2A9MDU8_9APIC/96-179     AC A0A2A9MDU8.1
#=GS A0A087XA43_POEFO/54-201     AC A0A087XA43.2
#=GS A0A0E0MRD5_ORYRU/75-224     AC A0A0E0MRD5.1
#=GS A0A1V6YK90_PENNA/69-227     AC A0A1V6YK90.1
#=GS A0A5M9JG65_MONFR/68-217     AC A0A5M9JG65.1
#=GS B6AGC6_CRYMR/52-233         AC B6AGC6.1
#=GS A0A1E4TNB7_PACTA/57-201     AC A0A1E4TNB7.1
#=GS A0A671E0H8_RHIFE/194-347    AC A0A671E0H8.1
#=GS A0A1V4JDF5_PATFA/195-356    AC A0A1V4JDF5.1
#=GS H0EM41_GLAL7/1-147          AC H0EM41.1
#=GS M3WA17_FELCA/195-356        AC M3WA17.1
#=GS A0A2I3GB44_NOMLE/140-301    AC A0A2I3GB44.1
#=GS B8ADA8_ORYSI/46-159         AC B8ADA8.1
#=GS D3Z8V6_RAT/65-224           AC D3Z8V6.1
#=GS V4SBU1_9ROSI/55-213         AC V4SBU1.1
#=GS A0A2K5BWS9_AOTNA/63-216     AC A0A2K5BWS9.1
#=GS A0A672U917_STRHB/195-356    AC A0A672U917.1
#=GS A0A0C9XF89_9AGAR/113-271    AC A0A0C9XF89.1
#=GS A0A091LDG3_9GRUI/1-121      AC A0A091LDG3.1
#=GS A0A3Q7W894_URSAR/85-246     AC A0A3Q7W894.1
#=GS A0A316Z1M2_9BASI/109-262    AC A0A316Z1M2.1
#=GS A0A0E0JE34_ORYPU/2-155      AC A0A0E0JE34.1
#=GS A0A059LP53_9CHLO/51-227     AC A0A059LP53.1
#=GS A0A2H3D836_ARMGA/112-270    AC A0A2H3D836.1
#=GS A0A512UBA2_9ASCO/59-212     AC A0A512UBA2.1
#=GS A0A0E0HQP7_ORYNI/53-214     AC A0A0E0HQP7.1
#=GS A0A1E4SKS7_9ASCO/81-205     AC A0A1E4SKS7.1
#=GS A0A2Y9EMA0_PHYMC/195-356    AC A0A2Y9EMA0.1
#=GS A0A507F328_9FUNG/56-135     AC A0A507F328.1
#=GS A0A0R4IDB5_DANRE/198-359    AC A0A0R4IDB5.2
#=GS A0A1L8FQX1_XENLA/57-218     AC A0A1L8FQX1.1
#=GS A0A4X2M7V5_VOMUR/79-240     AC A0A4X2M7V5.1
#=GS A0A5D2VNV0_GOSMU/52-211     AC A0A5D2VNV0.1
#=GS A0A5N3X676_MUNRE/74-233     AC A0A5N3X676.1
#=GS A0A6I8U926_AEDAE/58-219     AC A0A6I8U926.1
#=GS A0A1V6T899_9EURO/69-227     AC A0A1V6T899.1
#=GS A0A445A215_ARAHY/50-126     AC A0A445A215.1
#=GS A0A2K6FQF3_PROCO/46-206     AC A0A2K6FQF3.1
#=GS A0A093IVW3_FULGA/48-209     AC A0A093IVW3.1
#=GS A0A0D0BCP0_9AGAM/111-264    AC A0A0D0BCP0.1
#=GS H2AMH8_KAZAF/53-206         AC H2AMH8.1
#=GS S7RUU0_GLOTA/135-305        AC S7RUU0.1
#=GS F2UE60_SALR5/63-231         AC F2UE60.1
#=GS A0A1L9S0K9_ASPWE/61-217     AC A0A1L9S0K9.1
#=GS C5KJL4_PERM5/48-76          AC C5KJL4.1
#=GS A0A0G4KCT3_9PEZI/63-211     AC A0A0G4KCT3.1
#=GS A0A5N6ZIY2_9EURO/65-229     AC A0A5N6ZIY2.1
#=GS A0A5N6DGR3_ASPPA/54-202     AC A0A5N6DGR3.1
#=GS A0A2H9TGB7_9FUNG/86-233     AC A0A2H9TGB7.1
#=GS M0S8G0_MUSAM/52-211         AC M0S8G0.1
#=GS A6QVA2_AJECN/3-108          AC A6QVA2.1
#=GS U7PYE4_SPOS1/65-228         AC U7PYE4.1
#=GS A0A0D9Y3A8_9ORYZ/75-230     AC A0A0D9Y3A8.1
#=GS A0A166ZP02_METRR/158-306    AC A0A166ZP02.1
#=GS A0A060VQ05_ONCMY/58-219     AC A0A060VQ05.1
#=GS A0A6I8NXW9_ORNAN/77-238     AC A0A6I8NXW9.1
#=GS A0A2K0WUW1_GIBNY/1-146      AC A0A2K0WUW1.1
#=GS A0A395M4G7_9HYPO/66-214     AC A0A395M4G7.1
#=GS A0A2H2I3H0_CAEJA/50-212     AC A0A2H2I3H0.1
#=GS F9G388_FUSOF/58-197         AC F9G388.1
#=GS B8AZ03_ORYSI/52-211         AC B8AZ03.1
#=GS A0A2V0PGR2_9CHLO/49-228     AC A0A2V0PGR2.1
#=GS A0A1S7HKK6_9SACH/63-216     AC A0A1S7HKK6.1
#=GS A0A2R8M6D3_CALJA/85-241     AC A0A2R8M6D3.1
#=GS G0S6W8_CHATD/54-203         AC G0S6W8.1
#=GS A0A2I3TGB5_PANTR/119-275    AC A0A2I3TGB5.1
#=GS S7PZ05_MYOBR/98-257         AC S7PZ05.1
#=GS A0A4W4GAG1_ELEEL/25-172     AC A0A4W4GAG1.1
#=GS A0A0N5D787_THECL/52-199     AC A0A0N5D787.1
#=GS E3QNI7_COLGM/62-211         AC E3QNI7.1
#=GS W4G190_9STRA/63-170         AC W4G190.1
#=GS A0A3P7E7S9_WUCBA/244-329    AC A0A3P7E7S9.1
#=GS A0A1Y1IJQ7_KLENI/52-209     AC A0A1Y1IJQ7.1
#=GS A0A3B0JZE8_DROGU/178-260    AC A0A3B0JZE8.1
#=GS A0A446WNP6_TRITD/1-33       AC A0A446WNP6.1
#=GS C1E6J6_MICCC/51-210         AC C1E6J6.1
#=GS A0A4S2MFA3_OPIFE/226-387    AC A0A4S2MFA3.1
#=GS A0A3Q2HZS3_HORSE/65-224     AC A0A3Q2HZS3.1
#=GS A0A493ST49_ANAPP/1-135      AC A0A493ST49.1
#=GS A0A395HTL6_ASPHC/53-206     AC A0A395HTL6.1
#=GS S9VJG2_9TRYP/1-115          AC S9VJG2.1
#=GS A0A195CYE2_9HYME/63-228     AC A0A195CYE2.1
#=GS A0A2R8MF79_CALJA/85-246     AC A0A2R8MF79.2
#=GS A0A087VKA7_BALRE/48-209     AC A0A087VKA7.1
#=GS A0A3Q2CFV2_CYPVA/191-329    AC A0A3Q2CFV2.1
#=GS E3RHA3_PYRTT/65-214         AC E3RHA3.1
#=GS J9IQG9_9SPIT/84-249         AC J9IQG9.1
#=GS A0A078AS75_STYLE/44-203     AC A0A078AS75.1
#=GS S0DQL0_GIBF5/58-208         AC S0DQL0.1
#=GS A0A439DIB7_9PEZI/60-154     AC A0A439DIB7.1
#=GS A0A2V3ITC7_9FLOR/47-209     AC A0A2V3ITC7.1
#=GS A0A3Q1HFZ3_ANATE/73-234     AC A0A3Q1HFZ3.1
#=GS A0A673VWJ5_SALTR/191-340    AC A0A673VWJ5.1
#=GS Q7QFV7_ANOGA/58-219         AC Q7QFV7.4
#=GS A0A1S3IVN0_LINUN/60-221     AC A0A1S3IVN0.1
#=GS A0A0E9N8W3_SAICN/151-300    AC A0A0E9N8W3.1
#=GS K7FC07_PELSI/1-135          AC K7FC07.1
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