GenomeNet

Database: Pfam
Entry: Peptidase_C47
LinkDB: Peptidase_C47
Original site: Peptidase_C47 
#=GF ID   Peptidase_C47
#=GF AC   PF05543.13
#=GF DE   Staphopain peptidase C47
#=GF AU   Studholme DJ;0000-0002-3010-6637
#=GF SE   Merops
#=GF GA   22.60 22.60;
#=GF TC   23.10 26.60;
#=GF NC   22.40 22.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11767947
#=GF RT   Molecular cloning and biochemical characterisation of proteases
#=GF RT   from Staphylococcus epidermidis. 
#=GF RA   Dubin G, Chmiel D, Mak P, Rakwalska M, Rzychon M, Dubin A; 
#=GF RL   Biol Chem 2001;382:1575-1582.
#=GF RN   [2]
#=GF RM   11447146
#=GF RT   Decreased amounts of cell wall-associated protein A and
#=GF RT   fibronectin-binding proteins in Staphylococcus aureus sarA
#=GF RT   mutants due to up-regulation of extracellular proteases. 
#=GF RA   Karlsson A, Saravia-Otten P, Tegmark K, Morfeldt E, Arvidson S; 
#=GF RL   Infect Immun 2001;69:4742-4748.
#=GF RN   [3]
#=GF RM   12437090
#=GF RT   Extracellular proteases of Staphylococcus spp. 
#=GF RA   Dubin G; 
#=GF RL   Biol Chem 2002;383:1075-1086.
#=GF DR   INTERPRO; IPR008750;
#=GF DR   MEROPS; C47;
#=GF DR   SCOP; 1cv8; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Staphopains are one of four major families of  proteinases
#=GF CC   secreted by  the Gram-positive Staphylococcus aureus. These
#=GF CC   staphylococcal cysteine proteases are secreted as preproenzymes
#=GF CC   that are proteolytically cleaved to generate the mature enzyme.
#=GF SQ   25
#=GS L7WYB6_STAWS/214-388      AC L7WYB6.1
#=GS L7WTA7_STAWS/222-396      AC L7WTA7.1
#=GS R2T597_9ENTE/215-389      AC R2T597.1
#=GS A0A1E5GQW8_9ENTE/153-330  AC A0A1E5GQW8.1
#=GS A0A1E5GVY8_9ENTE/215-380  AC A0A1E5GVY8.1
#=GS C2BHS4_9FIRM/221-383      AC C2BHS4.1
#=GS A0A239UAF6_9STAP/214-388  AC A0A239UAF6.1
#=GS A0A200J0H3_9ENTE/115-287  AC A0A200J0H3.1
#=GS A0A1V1YYN9_9ACTN/214-388  AC A0A1V1YYN9.1
#=GS U7PBZ6_STASI/215-388      AC U7PBZ6.1
#=GS SSPB_STAA8/220-393        AC Q2FZL3.1
#=GS A0A290PYK8_9LACT/489-673  AC A0A290PYK8.1
#=GS ECPA_STAEQ/221-395        AC Q5HKF6.1
#=GS A0A1I5YYE7_9FIRM/214-382  AC A0A1I5YYE7.1
#=GS SSPP_STAA8/215-388        AC Q2G2R8.1
#=GS A0A0A8HUT9_STAHY/215-388  AC A0A0A8HUT9.1
#=GS A0A1R4J9T9_9SPHI/181-361  AC A0A1R4J9T9.1
#=GS A0A1I5IKN3_9FIRM/200-369  AC A0A1I5IKN3.1
#=GS A0A0U2LXD1_9ENTE/182-350  AC A0A0U2LXD1.1
#=GS A0A1M4X7Y6_9FIRM/201-369  AC A0A1M4X7Y6.1
#=GS A0A1E5L0S6_9ENTE/196-373  AC A0A1E5L0S6.1
#=GS A0A200J963_9ENTE/220-396  AC A0A200J963.1
#=GS A0A200IZE2_9ENTE/198-366  AC A0A200IZE2.1
#=GS A0A1R4JA38_9SPHI/23-139   AC A0A1R4JA38.1
#=GS A0A1V1Z0L3_9ACTN/222-396  AC A0A1V1Z0L3.1
L7WYB6_STAWS/214-388                 ...........nq-QPQYVNTLKNMQIRETQG.QNGWCAGYTMAFLLN..A.TYNTGH..YNAEMIMRALHPNLSGQAFQ.F.....T.G.....LTPQEMMRYGQSQ.GRNVNYLNRMPQ...F.NEVD.RLTKQNKGIA..LISSSV.EPRNGIHAGHAMAVAGN..A.....V.L....NN...NQ..RVIL....IWNPWDN...GLT.TQSADS..NVIP.V.SDG.THFRWNASIYGY..........................
L7WTA7_STAWS/222-396                 ...........dn-QVQYENTLKNFKIREQQF.DNSWCAGFSMAALLN..A.TKNTDK..YNAHDIMRTLYPNVSEEELP.Q.....F.S.....TNPHQMIKYGNSQ.GRDIQHQSGMPS...Y.NQID.QLTKDNKGAM..ILAHSVeNNPNDPHLGHAMAVVGN..A.....K.I....-N...NE..DKLI....FWNPWDT...DLS.IQDADS..NLLH.L.SFN.RDYTWDDTMIGY..........................
R2T597_9ENTE/215-389                 nysmidlkiyenq-------------LQVNGG.KNEWCMGYALSAIAN..T.KRSSFY..LKAETVMRHFFPKATGQSFYmN.....G.G.....INMQQAMDYSKSKlGMNPYYVNRPLT...LaENRN.ELNKGN-PVF..VFAKVE.YDTNAKYAYHALVLHGW..V.....N.P....DK...GL..NVYY....IWNPWYP...HT-.------..----.-.---.------------ncidggvksptlpfpggkftwehslr
A0A1E5GQW8_9ENTE/153-330             ......staknya--------MINWRINETQG.DVPWCAAFVTAAILS..N.KVDARA..TRAVDIVSYSFPKLTPKQRE.Q.....N.G.....VSPNQILAYANYR.KTYPKLVESTVN...H.SVIE.SNLRKGNALY..IGGIG-.YGSQTSKSRHAFALYGW..V.....D.N....ENpsgGKpyRVYY....VWNPWWN...YPM.TVQGNTlpMTIP.V.-PG.GGYTWYRTIYN-f.........................
A0A1E5GVY8_9ENTE/215-380             ......lnkfgtr---------INWKISEIQK.GNDWCMAYATTMILI..N.KNDART..TKVSDIVKW------GKKGK.N.....N.G.....FTPEEIIKYAKTR.GVYPKLLERPTT...W.SE--.SLTQFRKSNA..LLGLWK.SQVNTFHAIDLLGTYSE..N.....Y.M....GK...QM..NGYI....IWNPWNN...YTE.IIDASP..KQIKyI.ANSkRTYTWIGTIT--nw........................
C2BHS4_9FIRM/221-383                 ......ssskyid-----------LDLAETQE.DQSWCSAFAGAQILR..Q.RGK-GK..IYANNIMRYFYPNVSYDDLK.K.....K.S.....ISHNQLIKYANNK.KSYPSKSTGTLS...L.DSVK.KQIDSNKSIY..LSCDGT.G--TYKKANHALVLRGY..N.....T.R....NN...TY..---S....VWNPWDD...SYV.SMSISS..KSIS.V.-NG.GKFIWSSTIYGW..........................
A0A239UAF6_9STAP/214-388             ...........va--TKYVNTLPHFQIRETQG.NNGWCAGFTMAALLN..A.TKNTNQ..YRAQDIMRTIHPGLSGQRFQ.F.....T.G.....LTPDEMIQYGRSQ.GKNPRLYNGMPS...F.EMVD.QYTSKNQGIA..ILSQRLeASPNGLHGRHAMAVVGN..A.....V.L....AN...GQ..KVIV....FWNPWDR...DVS.LQPADS..DIIP.V.SDG.SHFKWFSAIPGY..........................
A0A200J0H3_9ENTE/115-287             .....eidsnilp-----------WTVYETQT.DKPWCQYYTYAAVIN..N.QAGKEI..TSAKKIIDGTYPQATDEQKE.D.....T.SwiisnSVNESMNYVNKTF.DKDLKRTPGLLS...F.DKVK.AEIDNHRPVI.tNLKSDTtEAHSIVQMGY-TAVQGN..P.....S.L....--...-K..PFYH....YWNPWWE...DTF.VVSSNS..PYIF.L.G-E.DKYEWYYTMYN-f.........................
A0A1V1YYN9_9ACTN/214-388             ...........nq-QPQYVNTLKNMQIRETQG.QNGWCAGYTMAFLLN..A.TYNTGH..YNAEMIMRALHPNLSGQAFQ.F.....T.G.....LTPQEMMRYGQSQ.GRNVNYLNRMPQ...F.NEVD.RLTKQNKGIA..LISSSV.EPRNGIHAGHAMAVAGN..A.....V.L....NN...NQ..RVIL....IWNPWDN...GLT.TQSADS..NVIP.V.SDG.THFRWNASIYGY..........................
U7PBZ6_STASI/215-388                 ...........va--TKYVNLLPNFQIREQQG.NNGWCAGYTMAALLN..A.TKNTSQ..YRAQDVMHQIHPGLSGQAFQ.F.....T.G.....LTADEMIQYGRAQ.GKNTSYYNGMPS...F.NMVD.QYTKDNKGIA..ILGKQI.EATQGMHAGHAMAVVGN..A.....V.T....AD...NQ..QVIV....FWNPWDR...DYS.LQPADS..NVIP.V.SNG.DHYHWYGSVVGF..........................
SSPB_STAA8/220-393                   .............DQVQYENTLKNFKIREQQF.DNSWCAGFSMAALLN..A.TKNTDT..YNAHDIMRTLYPEVSEQDLP.N.....C.A.....TFPNQMIEYGKSQ.GRDIHYQEGVPS...Y.EQVD.QLTKDNVGIM..ILAQSVsQNPNDPHLGHALAVVGN..A.....K.I....-N...DQ..EKLI....YWNPWDT...ELS.IQDADS..SLLH.L.SFN.RDYNWYGSMIGY..........................
A0A290PYK8_9LACT/489-673             ........ektgt-----FNSNNNFYIRETQG.SEPWCAAYVNAAAIN..TlGKATDTpiTTAKTIMQADCPDLSDEELS.K.....TqG.....STIENFVNIINSKyNMGVTVEDRALS...F.DEVK.KEIDDGLIIEmdVYDANAeTYEEKLKTEHAVAIVGY..V.....T.P....RD...GD..KSKVpyyeIWNPWWP...STF.YIPANA..ETFN.L.G-G.VNYKWGRSWY--nw........................
ECPA_STAEQ/221-395                   ..........emy--AEYVNQLKNFRIRETQG.YNSWCAGYTMSALLN..A.TYNTNR..YNAESVMRYLHPNLRGHDFQ.F.....T.G.....LTSNEMLRFGRSQ.GRNTQYLNRMTS...Y.NEVD.QLTTNNQGIA..VLGKRV.ESSDGIHAGHAMAVAGN..A.....K.V....NN...GQ..KVIL....IWNPWDN...GLM.TQDAHS..NIIP.V.SNG.DHYEWYASIYGY..........................
A0A1I5YYE7_9FIRM/214-382             ..tvnntlprfky---------LNTTIRETQS.SYPWCAAYVTAFIVN..F.RTGRTD..IRAIDVVKFAHPNSN--NIY.Q.....E.S.....VSREQCIAFAKKY.GLNPYEPSSNIS...Y.STAK.HQIAAEKPVY..MGCDEI.--SGDKKGRHALALRGY..N.....-.-....-E...QT..GVFS....VWNPWYN...YYE.TMPIDT..RIYT.A.TNG.SRWEWKRSII--dw........................
SSPP_STAA8/215-388                   ............y-NEQYINKLENFKIRETQG.NNGWCAGYTMSELLN..A.TYNTNK..YHAEAVMRFLHPNLQGQRFQ.F.....T.G.....LTPREMIYFGQTQ.GRSPQLLNRMTT...Y.NEVD.NLTKNNKGIA..VLGSRV.ESRNGMHAGHAMAVVGN..A.....K.L....DN...GQ..EVII....IWNPWDN...GFM.TQDAKN..NVIP.V.SNG.DHYRWYSSIYGY..........................
A0A0A8HUT9_STAHY/215-388             ............y-QNMYVNKLKNFKIREQQG.NNGWCAGYTMAALLN..A.TYNTDK..YFAEGVMRYLHPDLFGKEFQ.F.....T.G.....LRPEEMIKYGRDQ.GRDPKLVNRMTS...Y.DEVN.NLTNQNKGIA..VLGRQI.ELRNGLHAGHAMAVVGN..A.....K.L....EN...GK..EVIL....IWNPWDR...DFM.TQDAQS..RVIP.V.SNG.DHYNWSASIYGY..........................
A0A1R4J9T9_9SPHI/181-361             ........vpeyn-----RNIIPNWMITETQG.LEPWCAFYTLSTMIN..S.IEGKAI..TNAKTLIKKAFRTASEAELV.DgkyitS.K.....PFAHTVQTMQKEY.GYTLDIKNSRLT...P.AEVQ.TQIDKKAPVY..VHLDNV.TQNYNPAKSHGVTVIGYiiA.....K.N....NT...LD..SYYY....FWNPWWQ...KVM.LTNQKD..MSNW.K.LND.NVYSWKY-----sginf.....................
A0A1I5IKN3_9FIRM/200-369             ...psykflqigw--------------DETQG.NLPWCMAYVTASIMRykT.GKSLST..ISARKVMEWAYPNLTKAELE.A.....T.A.....LSTSKADEYANTY.DIDPTYTASRRT...Y.AQVA.SDIIADSPLA..FICDNV.NT--GAKKSHAFVCRGY..N.....D.-....NS...GN..SFYS....IWNPWYS...EFErIYTSDN..TYVN.S.AGT.AKYLWSATMYGW..........................
A0A0U2LXD1_9ENTE/182-350             .....tvdqtgtk---------INWNVTETQKsDEQWCSAYAAAMILN..N.KNDARP..TTAKQMAQFAGK------NK.N.....Q.A.....LSAQNVIEYANSR.GVYPYYVNRPMN...W.QEV-.-LTQVRKSNA..IWGAWEgFGGNYQGKWHALDIIGT..Y.....K.VpgwgGG...EQ..RAYF....VWNPWYT...YPE.LCNSDN..NTYY.L.---.------------vgssfvwrysvtn.............
A0A1M4X7Y6_9FIRM/201-369             ....sykflqigw--------------DETQG.DLPWCMAYVTASIMRykT.GKSLST..ISARKVMEWAYPNLTKAELE.A.....T.A.....LSTSKADEYANTY.NIDPTYTASRRT...Y.AQVA.SDIKADSPLA..FICDNV.NT--GAKKSHAFVCRGY..N.....D.-....NS...GN..PFYS....IWNPWYS...EFErIFTSDN..TYVN.S.AGT.AKYLWSATMYGW..........................
A0A1E5L0S6_9ENTE/196-373             .....alvefdtn--------ILPWNVYETQG.NQPWCQSFTMAAAIN..H.QAGKQV..TSASDIIHKSHPKATEAQLM.D.....S.N.....WIVKQSL-FDIIN.YVNKTYNYSLKF...E.NDIL.PFTMIKNEII..NKAPVItDLKSTTTAGHSIALIGY..TapksgD.I....NS...YP..PYYF....YWNPWWE...DTF.IVSSKS..QYMT.L.GS-.TNYEWYRSIYNY..........................
A0A200J963_9ENTE/220-396             .......taknya--------MINWKINETQG.DVPWCAAFVTAAILS..N.KVDARA..TRAVDIVNYSYPKLTAKQRE.Q.....N.G.....VSPQQILAYANYR.KTYPKIVESTVS...H.SVIEsNLRKGN-AL-..YLGGIG.YGSQTSKSRHAFALYGW..V.....D.N....ENpsgGKpyRVYY....VWNPWWN...YPM.TVQGNT..LPIT.IpVPG.GGYTWYRTIYN-f.........................
A0A200IZE2_9ENTE/198-366             .....eidsnilp-----------WTVYETQT.DKPWCQYYTYAAVIN..N.QAGKEI..TSAKKIIDGTYPQATDEQKE.D.....T.SwiisnSVNESMNYVNKTF.DKDLKRTPGLLS...F.DKVK.AEIDNHRPVI.tNLKSDTtEAHSIVQMGY-TAVQGN..P.....S.L....--...-K..PFYH....YWNPWWE...DTF.VVSSNS..PYIF.L.G-E.DKYEWY------yt........................
A0A1R4JA38_9SPHI/23-139              .......aapemk-------SLANFETNDQ-H.YDLQGIEHSFAKVLN..F.KTNRKD..ITAKTILKFVYPKKTDKEFN.N.....A.S.....VSIKDCIRYATSI.GVNMEWLDATKNelnF.NQV-.----------..------.-----------------..-.....-.-....--...--..----....-------...---.------..----.-.---.------------kseldkdhpvllcykpnktdwme...
A0A1V1Z0L3_9ACTN/222-396             ...........dn-QVQYENTLKNFKIREQQF.DNSWCAGFSMAALLN..A.TKNTDK..YKAYDIMRTLYPDVSEEELP.Q.....Y.S.....TNPQQMIKYGNSQ.GRDIQHQSGMPS...Y.NQVD.QLTKENKGAM..ILAHSVeNNPNDPHLGHAMAVVGN..A.....K.I....-N...NE..DKLI....FWNPWDT...DLS.IQDADS..NLLH.L.SFN.RDYTWDDTMIGY..........................
#=GC seq_cons                        ...........ht........h.NapIpETQG.sssWCAuYohAulLN..s.ptsssp..hpAcsIM+hhaPslospphp.p.....s.u.....lospphlpYupop.Gpssphhsuhho...a.spVc.phpcsspulh..llupsl.pspssh+suHAhAlhG...s.....p.h....ts...sp..phhh....lWNPW.s...ph..h.suco..phls.l.uss.scYpW.tohhs...........................
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