#=GF ID   Peptidase_C47
#=GF AC   PF05543.17
#=GF DE   Staphopain peptidase C47
#=GF AU   Studholme DJ;0000-0002-3010-6637
#=GF SE   Merops
#=GF GA   22.60 22.60;
#=GF TC   22.90 22.70;
#=GF NC   22.40 22.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0125
#=GF RN   [1]
#=GF RM   11767947
#=GF RT   Molecular cloning and biochemical characterisation of proteases
#=GF RT   from Staphylococcus epidermidis. 
#=GF RA   Dubin G, Chmiel D, Mak P, Rakwalska M, Rzychon M, Dubin A; 
#=GF RL   Biol Chem 2001;382:1575-1582.
#=GF RN   [2]
#=GF RM   11447146
#=GF RT   Decreased amounts of cell wall-associated protein A and
#=GF RT   fibronectin-binding proteins in Staphylococcus aureus sarA
#=GF RT   mutants due to up-regulation of extracellular proteases. 
#=GF RA   Karlsson A, Saravia-Otten P, Tegmark K, Morfeldt E, Arvidson S; 
#=GF RL   Infect Immun 2001;69:4742-4748.
#=GF RN   [3]
#=GF RM   12437090
#=GF RT   Extracellular proteases of Staphylococcus spp. 
#=GF RA   Dubin G; 
#=GF RL   Biol Chem 2002;383:1075-1086.
#=GF DR   INTERPRO; IPR008750;
#=GF DR   MEROPS; C47;
#=GF DR   SCOP; 1cv8; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Staphopains are one of four major families of  proteinases
#=GF CC   secreted by  the Gram-positive Staphylococcus aureus. These
#=GF CC   staphylococcal cysteine proteases are secreted as preproenzymes
#=GF CC   that are proteolytically cleaved to generate the mature enzyme.
#=GF SQ   15
#=GS A0A4Z1C3R0_9RHOB/91-259   AC A0A4Z1C3R0.1
#=GS A0A1I5YYE7_9FIRM/214-382  AC A0A1I5YYE7.1
#=GS A0A8J8M8A5_9FIRM/201-364  AC A0A8J8M8A5.1
#=GS A0A1E5GT34_9ENTE/185-362  AC A0A1E5GT34.1
#=GS A0A143PC52_9STAP/220-393  AC A0A143PC52.1
#=GS C2BHS4_9FIRM/221-383      AC C2BHS4.1
#=GS SSPB_STAA8/220-393        AC Q2FZL3.1
#=GS A0A1E5L0S6_9ENTE/196-373  AC A0A1E5L0S6.1
#=GS A0A380GY49_9STAP/1-146    AC A0A380GY49.1
#=GS SSPP_STAA8/215-388        AC Q2G2R8.1
#=GS A0A1I5IKN3_9FIRM/200-369  AC A0A1I5IKN3.1
#=GS ECPA_STAEQ/221-395        AC Q5HKF6.1
#=GS A0A1M4X7Y6_9FIRM/201-369  AC A0A1M4X7Y6.1
#=GS A0A7X1Z9E2_9LACT/628-805  AC A0A7X1Z9E2.1
#=GS W1W5U6_9STAP/221-395      AC W1W5U6.1
A0A4Z1C3R0_9RHOB/91-259              ...sgdnfimi----------DWRIAETQTSLPWCAAYVEAAILC..NKI...D..V.RATSARAIMCYIYPNLTEKQLENAKLN.QNQVI....KY.ANY.CGVYPQKVSRTLTLSEVQ--TQLRKGNA..IYMGTA.GYGNYS..NSRHALALFGWV.....N.Q..-GDY.....QTYY.VWNPWYN...YPT.VISANA--------------------gpvtipvpgggftwdntitn
A0A1I5YYE7_9FIRM/214-382             tvnntlprfky---------LNTTIRETQSSYPWCAAYVTAFIVN..FRT...G..R.TDIRAIDVVKFAHPNSN--NIYQESVS.REQCI....AF.AKK.YGLNPYEPSSNISYSTAKHQIAAEKPVY..MGCDEI.--SGDK..KGRHALALRGYN.....-.-..-EQT.....GVFS.VWNPWYN...YYE.TMPIDTRIYTATNGSRWEWKRSII--dw..................
A0A8J8M8A5_9FIRM/201-364             .dsvssnnlsl------------DLAETQGQQSWCSAFAGAAIIR..YKT...H..T.NVF-AKDIMKYYHPNSE--KLEDEYIT.NYQLI....RY.AQR.KGLYPRRRSYTLSLSSVVSQIDNSQPMY..IGCQGR.GDYE--..GARHALVLRGYD.....K.T..NNTY.....---S.IWNPWYK...YYE.TMPMDTKVYTVDPSASFKWDTTIYD-w...................
A0A1E5GT34_9ENTE/185-362             ........asv---EFETNILPWPVYETQTDQPWCQEFTMASVIN..YQV...G..K.QVTSASDIIHKSYPRATESQLMDINWV.TKQSLnditNYvNKA.YNYSIKFEGNKLPFSMIKNEIANNAPVI..T-----.DLNSST..TYGHSIVLMGYT.....A.P..KNGDitsylPYYF.YWNPWWE...DTF.IVSSNSKYMTLGQ-TKYEWYRTLYN-f...................
A0A143PC52_9STAP/220-393             .........va--TKYVNTLPHFQIRETQGNNGWCAGFTMAALLN..ATK...N..T.NQYRAQDIMRTIHPGLSGQRFQFTGLT.PDEMI....QY.GRS.QGKNPTYYNSMPSYDMVDQYTSDNKGIA..ILSERV.ESTNGL..HGRHAMAVVGNA.....V.L..ANNQ.....KVIV.FWNPWDS...DVS.LQPVDSNIIPVSDGSHFRWFASIPGY....................
C2BHS4_9FIRM/221-383                 ....ssskyid-----------LDLAETQEDQSWCSAFAGAQILR..QRG...K..-.GKIYANNIMRYFYPNVSYDDLKKKSIS.HNQLI....KY.ANN.KKSYPSKSTGTLSLDSVKKQIDSNKSIY..LSCDGT.G--TYK..KANHALVLRGYN.....T.R..NNTY.....---S.VWNPWDD...SYV.SMSISSKSISV-NGGKFIWSSTIYGW....................
SSPB_STAA8/220-393                   ...........DQVQYENTLKNFKIREQQFDNSWCAGFSMAALLN..ATK...N..T.DTYNAHDIMRTLYPEVSEQDLPNCATF.PNQMI....EY.GKS.QGRDIHYQEGVPSYEQVDQLTKDNVGIM..ILAQSVsQNPNDP..HLGHALAVVGNA.....K.I..-NDQ.....EKLI.YWNPWDT...ELS.IQDADSSLLHLSFNRDYNWYGSMIGY....................
A0A1E5L0S6_9ENTE/196-373             ...alvefdtn--------ILPWNVYETQGNQPWCQSFTMAAAIN..HQA...G..K.QVTSASDIIHKSHPKATEAQLMDSNWI.VKQSL....-F.DII.NYVNKTYNYSLKFENDILPFTMIKNEII..NKAPVItDLKSTT..TAGHSIALIGYTapksgD.I..NSYP.....PYYF.YWNPWWE...DTF.IVSSKSQYMTLGS-TNYEWYRSIYNY....................
A0A380GY49_9STAP/1-146               ...........----------------------------MSAFLN..ATY...N..T.NRYNAEAVMRYLHPNLHGHDFQFTGLT.SGEMI....HF.CKT.QGRNPQYLNRMTSYNEVDQLTTNNQGTA..VLGKRV.ESSDGM..HAGHAMAVAGSA.....K.I..NNGQ.....EVIL.IWNHWDH...GFM.TQDAQNNIIPVSNGDHYEWYASIYGY....................
SSPP_STAA8/215-388                   ..........y-NEQYINKLENFKIRETQGNNGWCAGYTMSELLN..ATY...N..T.NKYHAEAVMRFLHPNLQGQRFQFTGLT.PREMI....YF.GQT.QGRSPQLLNRMTTYNEVDNLTKNNKGIA..VLGSRV.ESRNGM..HAGHAMAVVGNA.....K.L..DNGQ.....EVII.IWNPWDN...GFM.TQDAKNNVIPVSNGDHYRWYSSIYGY....................
A0A1I5IKN3_9FIRM/200-369             .psykflqigw--------------DETQGNLPWCMAYVTASIMRykTGK...S..L.STISARKVMEWAYPNLTKAELEATALS.TSKAD....EY.ANT.YDIDPTYTASRRTYAQVASDIIADSPLA..FICDNV.NT--GA..KKSHAFVCRGYN.....D.-..NSGN.....SFYS.IWNPWYS...EFErIYTSDNTYVNSAGTAKYLWSATMYGW....................
ECPA_STAEQ/221-395                   ........emy--AEYVNQLKNFRIRETQGYNSWCAGYTMSALLN..ATY...N..T.NRYNAESVMRYLHPNLRGHDFQFTGLT.SNEML....RF.GRS.QGRNTQYLNRMTSYNEVDQLTTNNQGIA..VLGKRV.ESSDGI..HAGHAMAVAGNA.....K.V..NNGQ.....KVIL.IWNPWDN...GLM.TQDAHSNIIPVSNGDHYEWYASIYGY....................
A0A1M4X7Y6_9FIRM/201-369             ..sykflqigw--------------DETQGDLPWCMAYVTASIMRykTGK...S..L.STISARKVMEWAYPNLTKAELEATALS.TSKAD....EY.ANT.YNIDPTYTASRRTYAQVASDIKADSPLA..FICDNV.NT--GA..KKSHAFVCRGYN.....D.-..NSGN.....PFYS.IWNPWYS...EFErIFTSDNTYVNSAGTAKYLWSATMYGW....................
A0A7X1Z9E2_9LACT/628-805             .....ksnanf------KTISSFSVREVQGQEPWCAEYDAAAIIN..SLNkisNesTnNVVTAKDLMASYLPGKTEEQLKKMGGQdIKSSL....TV.LKNkYQVAADVIDRKLTFGEVKQQIDNGQPIEmdVFDKDN.DAPRGTenNSGHAILIVGYVipkdgD.I..STHA.....PYYE.IWNPWWG...KTF.YVSSSASIIN----------------lcg.................
W1W5U6_9STAP/221-395                 ........emy--AEYVNQLKNFRIRETQGYNSWCAGYTMSALLN..ATY...N..T.NRYNAESVMRYLHPNLRGHDFQFTGLT.SNEML....RF.GRS.QGRNTQYLNRMTSYNEVDQLTTNNQGIA..VLGKRV.ESSDGI..HAGHAMAVAGNA.....K.V..NNGQ.....KVIL.IWNPWDN...GLM.TQDAHSNIIPVSNGDHYEWYASIYGY....................
#=GC seq_cons                        .........hh..........saplcETQGspsWCuuashAAllN..spt...s..s.sshsAcclM+ahaPNlotpcLptsulo.ssphl....ca.ups.pGhsPpahsphhoYspVcp.hssspslt..lhscpl.psssuh..+uuHAhAlhGas.....c.h..sNsp.....thhh.lWNPW.s...thh.hhsucosllslusss+YcWhuoIYGa....................
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