GenomeNet

Database: Pfam
Entry: Peptidase_M16_M
LinkDB: Peptidase_M16_M
Original site: Peptidase_M16_M 
#=GF ID   Peptidase_M16_M
#=GF AC   PF16187.7
#=GF DE   Middle or third domain of peptidase_M16
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Phmmer:P14735
#=GF GA   29.70 29.70;
#=GF TC   29.70 30.00;
#=GF NC   29.60 29.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0094
#=GF RN   [1]
#=GF RM   22049080
#=GF RT   Anion activation site of insulin-degrading enzyme.
#=GF RA   Noinaj N, Song ES, Bhasin S, Alper BJ, Schmidt WK, Hersh LB,
#=GF RA   Rodgers DW;
#=GF RL   J Biol Chem. 2012;287:48-57.
#=GF DR   INTERPRO; IPR032632;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Peptidase_M16_M is the third domain of peptidase_M16 in
#=GF CC   eukaryotes of the insulin-degrading-enzyme type.
#=GF CC   Insulin-degrading enzymes - insulysin - are zinc
#=GF CC   metallopeptidases that metabolise several bioactive peptides,
#=GF CC   including insulin and the amyloid-beta-peptide.  The tertiary
#=GF CC   structure of insulin-degrading enzymes resembles a clamshell
#=GF CC   composed of four structurally similar domains arranged to
#=GF CC   enclose a large central chamber. Substrates must enter the
#=GF CC   chamber, and it is likely that a hinge-like conformational
#=GF CC   change allows substrate binding and product release.
#=GF CC   Triphosphates are found to dock between the inner surfaces of
#=GF CC   the non-catalytic domains three and four [1].
#=GF SQ   4697
#=GS A0A195EJM5_9HYME/328-610    AC A0A195EJM5.1
#=GS A0A087VPQ5_BALRE/455-736    AC A0A087VPQ5.1
#=GS A0A1S3XFX6_TOBAC/6-286      AC A0A1S3XFX6.1
#=GS A0A2W1C0Q8_HELAM/313-411    AC A0A2W1C0Q8.1
#=GS A0A287HRN8_HORVV/312-592    AC A0A287HRN8.1
#=GS A0A3Q3AY03_KRYMA/383-664    AC A0A3Q3AY03.1
#=GS A0A6G1BDV3_CROCR/530-811    AC A0A6G1BDV3.1
#=GS A0A197K6S4_9FUNG/394-682    AC A0A197K6S4.1
#=GS A0A2T7P880_POMCA/380-661    AC A0A2T7P880.1
#=GS A0A4X2LSV5_VOMUR/617-898    AC A0A4X2LSV5.1
#=GS A0A0C3AAT8_9AGAM/445-739    AC A0A0C3AAT8.1
#=GS A0A4U5P056_STECR/365-533    AC A0A4U5P056.1
#=GS S9V1D8_9TRYP/272-514        AC S9V1D8.1
#=GS A0A136IK86_9PEZI/437-726    AC A0A136IK86.1
#=GS A0A1B7NA18_9AGAM/450-743    AC A0A1B7NA18.1
#=GS A0A379CAZ4_9PAST/417-695    AC A0A379CAZ4.1
#=GS A0A3B3I7A3_ORYLA/418-699    AC A0A3B3I7A3.1
#=GS A0A452RSE2_URSAM/297-563    AC A0A452RSE2.1
#=GS A0A078FB24_BRANA/585-680    AC A0A078FB24.1
#=GS A0A4W4EI08_ELEEL/381-662    AC A0A4W4EI08.1
#=GS A0A1G4JF66_9SACH/412-693    AC A0A1G4JF66.1
#=GS A0A430QUW6_SCHBO/415-687    AC A0A430QUW6.1
#=GS A0A1V4KIZ3_PATFA/427-708    AC A0A1V4KIZ3.1
#=GS A0A195FCQ6_9HYME/186-465    AC A0A195FCQ6.1
#=GS A0A558NKV7_9GAMM/395-670    AC A0A558NKV7.1
#=GS A0A6A5FB16_PERFL/569-721    AC A0A6A5FB16.1
#=GS A0A401GSE9_9APHY/412-701    AC A0A401GSE9.1
#=GS A0A1E7ETQ4_9STRA/429-750    AC A0A1E7ETQ4.1
#=GS A0A673XX35_SALTR/486-765    AC A0A673XX35.1
#=GS A0A673XA03_SALTR/395-673    AC A0A673XA03.1
#=GS A0A096MQL8_PAPAN/553-834    AC A0A096MQL8.2
#=GS A0A1D2VHV6_9ASCO/398-692    AC A0A1D2VHV6.1
#=GS A0A1V8M0S4_9GAMM/372-650    AC A0A1V8M0S4.1
#=GS Q6A598_CAEEL/660-744        AC Q6A598.1
#=GS A0A199UY94_ANACO/235-304    AC A0A199UY94.1
#=GS A0A240C988_SERFI/401-679    AC A0A240C988.1
#=GS A0A319CDP7_9EURO/493-781    AC A0A319CDP7.1
#=GS A0A3S2NGT0_CHISP/153-436    AC A0A3S2NGT0.1
#=GS D7THW8_VITVI/376-656        AC D7THW8.1
#=GS A0A3N9TYM8_9GAMM/420-690    AC A0A3N9TYM8.1
#=GS A0A109FL14_9BASI/398-682    AC A0A109FL14.1
#=GS A0A6Q2ZM34_ESOLU/513-794    AC A0A6Q2ZM34.1
#=GS A0A024GF41_9STRA/412-720    AC A0A024GF41.1
#=GS J9JW94_ACYPI/387-669        AC J9JW94.2
#=GS K5W524_PHACS/418-710        AC K5W524.1
#=GS A0A072U1Q0_MEDTR/378-658    AC A0A072U1Q0.1
#=GS A0A4W6D3C9_LATCA/501-796    AC A0A4W6D3C9.1
#=GS A0A0H5DQM8_9BACT/394-619    AC A0A0H5DQM8.1
#=GS A0A6A6KMZ9_HEVBR/313-405    AC A0A6A6KMZ9.1
#=GS A0A212CF23_CEREH/106-236    AC A0A212CF23.1
#=GS Q2SCD7_HAHCH/406-683        AC Q2SCD7.1
#=GS A0A1V0KP97_9GAMM/366-651    AC A0A1V0KP97.1
#=GS A0A3P7EJU6_HYDTA/1-191      AC A0A3P7EJU6.1
#=GS A0A0V0S2P6_9BILA/1129-1417  AC A0A0V0S2P6.1
#=GS B8KWW9_9GAMM/397-675        AC B8KWW9.1
#=GS A0A446M461_TRITD/398-678    AC A0A446M461.1
#=GS A0A1V2L4W8_CYBFA/377-658    AC A0A1V2L4W8.1
#=GS H2TVA3_TAKRU/454-735        AC H2TVA3.3
#=GS A0A3S3RT48_9ACAR/253-368    AC A0A3S3RT48.1
#=GS H0Y5G9_HUMAN/8-120          AC H0Y5G9.1
#=GS W7Q057_9GAMM/417-688        AC W7Q057.1
#=GS L5K6N1_PTEAL/581-862        AC L5K6N1.1
#=GS B3MXJ3_DROAN/449-737        AC B3MXJ3.1
#=GS A0A2G5CJE1_AQUCA/278-500    AC A0A2G5CJE1.1
#=GS A0A022PT65_ERYGU/380-660    AC A0A022PT65.1
#=GS A0A2G9UK12_TELCI/256-437    AC A0A2G9UK12.1
#=GS A0A672HCK9_SALFA/389-670    AC A0A672HCK9.1
#=GS A0A267G8U5_9PLAT/408-702    AC A0A267G8U5.1
#=GS B4NPT6_DROWI/505-792        AC B4NPT6.2
#=GS W7I5F2_9PEZI/388-686        AC W7I5F2.1
#=GS A0A066X9T5_COLSU/400-689    AC A0A066X9T5.1
#=GS A0A1V9X876_9ACAR/312-589    AC A0A1V9X876.1
#=GS A0A1B7UJG9_9GAMM/371-648    AC A0A1B7UJG9.1
#=GS A0A668AB41_9TELE/486-767    AC A0A668AB41.1
#=GS G8YT08_PICSO/429-762        AC G8YT08.1
#=GS A0A0F4PA78_9VIBR/366-643    AC A0A0F4PA78.1
#=GS D8PV33_SCHCM/442-737        AC D8PV33.1
#=GS A0A0P7VSF1_SCLFO/545-668    AC A0A0P7VSF1.1
#=GS E1V982_HALED/405-675        AC E1V982.1
#=GS A0A2I1G399_9GLOM/396-678    AC A0A2I1G399.1
#=GS PTRA_ECO57/400-678          AC Q8X6M8.1
#=GS A0A158NKU8_ATTCE/526-809    AC A0A158NKU8.1
#=GS R0H214_9BRAS/310-590        AC R0H214.1
#=GS A0A0W0G928_9AGAR/452-761    AC A0A0W0G928.1
#=GS A0A090UVH7_PSEVU/400-677    AC A0A090UVH7.1
#=GS A0A1B9GTI2_9TREE/397-683    AC A0A1B9GTI2.1
#=GS A0A5N6LDT3_9ASTR/405-625    AC A0A5N6LDT3.1
#=GS A0A195CAJ5_9HYME/393-673    AC A0A195CAJ5.1
#=GS A0A4W5L6C6_9TELE/388-666    AC A0A4W5L6C6.1
#=GS A0A151WZ94_9HYME/717-1002   AC A0A151WZ94.1
#=GS A0A151M4D9_ALLMI/495-776    AC A0A151M4D9.1
#=GS A0A545TDB1_9GAMM/399-676    AC A0A545TDB1.1
#=GS A0A158P677_ANGCA/372-576    AC A0A158P677.1
#=GS A0A453B9D9_AEGTS/1-223      AC A0A453B9D9.1
#=GS A0A0D3DTY7_BRAOL/390-670    AC A0A0D3DTY7.1
#=GS F6SD02_ORNAN/418-699        AC F6SD02.2
#=GS A0A669D8E4_ORENI/377-658    AC A0A669D8E4.1
#=GS A0A4W2CM19_BOBOX/422-703    AC A0A4W2CM19.1
#=GS A0A0E0C8H6_9ORYZ/725-1005   AC A0A0E0C8H6.1
#=GS A0A0E0LME8_ORYPU/1388-1667  AC A0A0E0LME8.1
#=GS S9VIA8_9TRYP/484-726        AC S9VIA8.1
#=GS A0A1R3IK87_COCAP/449-734    AC A0A1R3IK87.1
#=GS A0A1B7P7P5_9EURO/535-824    AC A0A1B7P7P5.1
#=GS A0A5N5GPK2_9ROSA/447-733    AC A0A5N5GPK2.1
#=GS A0A3N6QL15_BRACR/343-506    AC A0A3N6QL15.1
#=GS A0A1X7TYM8_AMPQE/468-771    AC A0A1X7TYM8.1
#=GS A0A0D1ZIG7_EXOME/453-741    AC A0A0D1ZIG7.1
#=GS A0A0J5LJ10_PLUGE/401-678    AC A0A0J5LJ10.1
#=GS A0A319EC57_ASPSB/494-782    AC A0A319EC57.1
#=GS A0A1U7S5R3_ALLSI/430-711    AC A0A1U7S5R3.1
#=GS A0A2C9V778_MANES/377-659    AC A0A2C9V778.1
#=GS A0A0G4F4E5_VITBC/477-850    AC A0A0G4F4E5.1
#=GS A0A2G7EM28_9EURO/416-704    AC A0A2G7EM28.1
#=GS A0A4V6A034_STECR/1-106      AC A0A4V6A034.1
#=GS M2UWW9_COCH5/411-698        AC M2UWW9.1
#=GS D8LK42_ECTSI/501-750        AC D8LK42.1
#=GS A0A4W2DXP1_BOBOX/744-874    AC A0A4W2DXP1.1
#=GS A0A673TIN3_SURSU/381-662    AC A0A673TIN3.1
#=GS V4SCI2_9ROSI/378-692        AC V4SCI2.1
#=GS A0A2K0WD32_GIBNY/411-701    AC A0A2K0WD32.1
#=GS A0A061EW04_THECC/36-316     AC A0A061EW04.1
#=GS A0A1L8GMF3_XENLA/498-779    AC A0A1L8GMF3.1
#=GS A0A0D3GSL0_9ORYZ/2346-2626  AC A0A0D3GSL0.1
#=GS A0A1A6G409_NEOLE/592-763    AC A0A1A6G409.1
#=GS A0A3S4R4R0_9ACAR/445-729    AC A0A3S4R4R0.1
#=GS A0A2N0G542_9GAMM/410-679    AC A0A2N0G542.1
#=GS E3RFZ3_PYRTT/412-699        AC E3RFZ3.1
#=GS A0A183MVN5_9TREM/353-414    AC A0A183MVN5.1
#=GS A0A667ZQK4_9TELE/381-662    AC A0A667ZQK4.1
#=GS A0A4W6D344_LATCA/454-749    AC A0A4W6D344.1
#=GS A0A428NLG1_9HYPO/410-507    AC A0A428NLG1.1
#=GS A0A372QF54_9GLOM/388-669    AC A0A372QF54.1
#=GS A0A445CEL8_ARAHY/68-127     AC A0A445CEL8.1
#=GS V4LQL6_EUTSA/383-663        AC V4LQL6.1
#=GS A0A2Y9ETR1_PHYMC/422-703    AC A0A2Y9ETR1.1
#=GS A0A367JJF8_RHIAZ/1-113      AC A0A367JJF8.1
#=GS A0A3P9C1K3_9CICH/381-662    AC A0A3P9C1K3.1
#=GS A0A0B8Q3J9_9VIBR/1-221      AC A0A0B8Q3J9.1
#=GS A0A4R0R7D9_9APHY/420-720    AC A0A4R0R7D9.1
#=GS B6JXW8_SCHJY/382-665        AC B6JXW8.1
#=GS A0A2K1L6U5_PHYPA/336-619    AC A0A2K1L6U5.1
#=GS A0A3P7BC50_HYMDI/6-118      AC A0A3P7BC50.1
#=GS A0A672JET8_SALFA/419-530    AC A0A672JET8.1
#=GS A0A0G4G7B4_VITBC/116-425    AC A0A0G4G7B4.1
#=GS A0A1B6QNE7_SORBI/452-738    AC A0A1B6QNE7.1
#=GS A0A3B0JZ57_DROGU/437-718    AC A0A3B0JZ57.1
#=GS O16249_CAEEL/660-744        AC O16249.1
#=GS A0A5E4G8R2_PRUDU/379-659    AC A0A5E4G8R2.1
#=GS A0A0E0QA39_ORYRU/456-736    AC A0A0E0QA39.1
#=GS A0A267FZA2_9PLAT/386-669    AC A0A267FZA2.1
#=GS A0A6A4G0G2_9STRA/431-716    AC A0A6A4G0G2.1
#=GS A0A5N5FYM2_9ROSA/382-662    AC A0A5N5FYM2.1
#=GS A0A672ZLN9_9TELE/328-608    AC A0A672ZLN9.1
#=GS A0A152A6E7_9MYCE/370-661    AC A0A152A6E7.1
#=GS A0A669D404_ORENI/319-600    AC A0A669D404.1
#=GS A0A198GCN4_9GAMM/401-679    AC A0A198GCN4.1
#=GS A0A367IWJ3_RHIST/1-97       AC A0A367IWJ3.1
#=GS A0A1Y6KSD1_9GAMM/366-645    AC A0A1Y6KSD1.1
#=GS A0A2I3GX60_NOMLE/372-653    AC A0A2I3GX60.1
#=GS A0A3Q0KQL3_SCHMA/423-710    AC A0A3Q0KQL3.1
#=GS A0A4W6E837_LATCA/500-781    AC A0A4W6E837.1
#=GS A0A195CEX7_9HYME/406-692    AC A0A195CEX7.1
#=GS A0A2X0M595_9BASI/572-857    AC A0A2X0M595.1
#=GS A0A0L9VCA9_PHAAN/601-874    AC A0A0L9VCA9.1
#=GS A0A1D6IH66_MAIZE/169-449    AC A0A1D6IH66.1
#=GS A0A4U5NWU3_STECR/421-676    AC A0A4U5NWU3.1
#=GS A0A164VFJ5_9CRUS/467-747    AC A0A164VFJ5.1
#=GS A0A1Z5J5M3_FISSO/460-763    AC A0A1Z5J5M3.1
#=GS A0A2P8ZMQ7_BLAGE/352-596    AC A0A2P8ZMQ7.1
#=GS A0A195F2Z7_9HYME/920-1197   AC A0A195F2Z7.1
#=GS A0A446NRJ9_TRITD/329-609    AC A0A446NRJ9.1
#=GS A0A453I5E0_AEGTS/1-218      AC A0A453I5E0.1
#=GS M2Y7D5_GALSU/397-692        AC M2Y7D5.1
#=GS A0A0M0J4F1_9EUKA/451-590    AC A0A0M0J4F1.1
#=GS A0A3N9TJ34_9VIBR/366-646    AC A0A3N9TJ34.1
#=GS A0A2K6C4R1_MACNE/422-703    AC A0A2K6C4R1.1
#=GS G9MMZ0_HYPVG/412-701        AC G9MMZ0.1
#=GS A0A3P9ADW7_ESOLU/381-663    AC A0A3P9ADW7.2
#=GS A0A2I3HN39_NOMLE/226-507    AC A0A2I3HN39.1
#=GS A0A195BIH3_9HYME/1239-1525  AC A0A195BIH3.1
#=GS A0A1X2GJS3_9FUNG/395-680    AC A0A1X2GJS3.1
#=GS U3CZU9_CALJA/553-834        AC U3CZU9.1
#=GS A0A1Y2A711_9PLEO/798-987    AC A0A1Y2A711.1
#=GS A0A2I4BBY7_9TELE/313-594    AC A0A2I4BBY7.1
#=GS A0A3Q7TMG3_URSAR/422-703    AC A0A3Q7TMG3.1
#=GS A0A1V9YCN4_9STRA/435-725    AC A0A1V9YCN4.1
#=GS A0A6H5GSB2_9HEMI/488-771    AC A0A6H5GSB2.1
#=GS G0MXI6_CAEBE/442-657        AC G0MXI6.1
#=GS A0A443SAP7_9ACAR/373-650    AC A0A443SAP7.1
#=GS A0A0G4PNQ7_PENCA/483-771    AC A0A0G4PNQ7.1
#=GS M1V9J9_CYAM1/447-759        AC M1V9J9.1
#=GS A0A2I0TBG2_LIMLA/172-246    AC A0A2I0TBG2.1
#=GS A0A2Y9D960_TRIMA/422-703    AC A0A2Y9D960.1
#=GS G4QKD7_GLANF/370-641        AC G4QKD7.1
#=GS A0A6A2WZ64_HIBSY/37-113     AC A0A6A2WZ64.1
#=GS A0A1R1MF37_9GAMM/390-667    AC A0A1R1MF37.1
#=GS A0A0E0C8H5_9ORYZ/744-1024   AC A0A0E0C8H5.1
#=GS B9RX17_RICCO/470-634        AC B9RX17.1
#=GS A0A5P1R9V5_9GAMM/395-675    AC A0A5P1R9V5.1
#=GS A0A4Q4UU96_9PEZI/399-688    AC A0A4Q4UU96.1
#=GS A0A0S2K692_9GAMM/425-704    AC A0A0S2K692.1
#=GS A0A093IPV8_FULGA/1-95       AC A0A093IPV8.1
#=GS A0A1U7ZU83_NELNU/342-622    AC A0A1U7ZU83.1
#=GS H2UTN2_TAKRU/464-745        AC H2UTN2.3
#=GS A0A4S2KSY9_9HYME/2-131      AC A0A4S2KSY9.1
#=GS A0A3N0Z9N2_ANAGA/486-767    AC A0A3N0Z9N2.1
#=GS Q4WE74_ASPFU/459-747        AC Q4WE74.1
#=GS A0A2G5TJI4_9PELO/658-741    AC A0A2G5TJI4.1
#=GS A0A4S2MQS9_9PEZI/387-681    AC A0A4S2MQS9.1
#=GS A0A0D2WPQ3_CAPO3/342-623    AC A0A0D2WPQ3.1
#=GS A0A1A6KPA3_9VIBR/371-649    AC A0A1A6KPA3.1
#=GS A0A668AI56_9TELE/506-787    AC A0A668AI56.1
#=GS A0A0J7JVJ9_LASNI/2-133      AC A0A0J7JVJ9.1
#=GS A0A1T4S0R6_9GAMM/401-675    AC A0A1T4S0R6.1
#=GS A0A5B8SNJ3_9GAMM/433-704    AC A0A5B8SNJ3.1
#=GS F6UVG9_CALJA/422-703        AC F6UVG9.2
#=GS A0A2G5TJI4_9PELO/442-656    AC A0A2G5TJI4.1
#=GS A0A1S2ZBM3_ERIEU/406-540    AC A0A1S2ZBM3.1
#=GS A0A4Y7QDH7_9AGAM/456-741    AC A0A4Y7QDH7.1
#=GS W9HH22_FUSOX/409-699        AC W9HH22.1
#=GS A0A1W9F681_9GAMM/69-193     AC A0A1W9F681.1
#=GS A0A6G1DMD3_9ORYZ/246-532    AC A0A6G1DMD3.1
#=GS A0A3Q2D5W2_CYPVA/478-759    AC A0A3Q2D5W2.1
#=GS A0A6G0YXE3_APHCR/162-444    AC A0A6G0YXE3.1
#=GS A0A6Q2YNW3_ESOLU/398-679    AC A0A6Q2YNW3.1
#=GS A0A2C9V7C0_MANES/373-653    AC A0A2C9V7C0.1
#=GS A0A5J4NZU5_9TREM/2-299      AC A0A5J4NZU5.1
#=GS A0A6I8SN21_XENTR/459-740    AC A0A6I8SN21.1
#=GS A0A3N4ISW3_ASCIM/390-665    AC A0A3N4ISW3.1
#=GS A0A2B7YJ62_9EURO/431-720    AC A0A2B7YJ62.1
#=GS I7MIE6_TETTS/378-670        AC I7MIE6.1
#=GS A0A452RSA9_URSAM/253-519    AC A0A452RSA9.1
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#=GS A0A328CY66_9ASTE/445-730    AC A0A328CY66.1
#=GS A0A1V6TBY4_9EURO/492-780    AC A0A1V6TBY4.1
#=GS A0A1V4JXZ3_PATFA/558-839    AC A0A1V4JXZ3.1
#=GS A0A4W5RE46_9TELE/451-732    AC A0A4W5RE46.1
#=GS A0A1D6PAV4_MAIZE/154-440    AC A0A1D6PAV4.1
#=GS A0A151JBR1_9HYME/378-650    AC A0A151JBR1.1
#=GS A0A340YGP4_LIPVE/422-703    AC A0A340YGP4.1
#=GS A0A493TI10_ANAPP/560-841    AC A0A493TI10.1
#=GS A0A162T0M6_9CRUS/543-831    AC A0A162T0M6.1
#=GS A0A2T0FFE0_9ASCO/377-659    AC A0A2T0FFE0.1
#=GS A0A0N4YDS1_NIPBR/419-551    AC A0A0N4YDS1.1
#=GS A0A428RHN6_9HYPO/355-540    AC A0A428RHN6.1
#=GS A0A367KWU6_RHIST/388-671    AC A0A367KWU6.1
#=GS A0A0Q3RAA6_BRADI/66-346     AC A0A0Q3RAA6.2
#=GS A0A2I0I7T8_PUNGR/11-216     AC A0A2I0I7T8.1
#=GS A0A5E4AQH0_MARMO/633-914    AC A0A5E4AQH0.1
#=GS A0A267DXA1_9PLAT/458-597    AC A0A267DXA1.1
#=GS K2KMW9_9GAMM/377-659        AC K2KMW9.1
#=GS U3AMS4_9VIBR/366-644        AC U3AMS4.1
#=GS A0A367L6W2_9HYPO/407-696    AC A0A367L6W2.1
#=GS A0A376B182_9ASCO/394-678    AC A0A376B182.1
#=GS A0A4W5JV87_9TELE/365-518    AC A0A4W5JV87.1
#=GS K3XE64_SETIT/383-663        AC K3XE64.1
#=GS A0A4U6W1P8_SETVI/397-677    AC A0A4U6W1P8.1
#=GS A0A0L7KYZ9_9NEOP/28-165     AC A0A0L7KYZ9.1
#=GS A0A4U6X5R6_9PEZI/417-706    AC A0A4U6X5R6.1
#=GS H0UUS1_CAVPO/422-703        AC H0UUS1.1
#=GS A0A662X6I0_9STRA/455-755    AC A0A662X6I0.1
#=GS A0A4S2KXE9_9HYME/530-819    AC A0A4S2KXE9.1
#=GS A0A195EYW9_9HYME/356-641    AC A0A195EYW9.1
#=GS A0A4S2LUW5_OPIFE/388-671    AC A0A4S2LUW5.1
#=GS A0A132A6Q4_SARSC/433-535    AC A0A132A6Q4.1
#=GS A0A0V0S2K8_9BILA/1123-1411  AC A0A0V0S2K8.1
#=GS A0A060XYZ3_ONCMY/418-699    AC A0A060XYZ3.1
#=GS A0A3P8FJY6_9TREM/95-290     AC A0A3P8FJY6.1
#=GS R0IGY5_SETT2/411-698        AC R0IGY5.1
#=GS A0A1E5RPN8_HANUV/487-785    AC A0A1E5RPN8.1
#=GS A0A068YEE4_ECHMU/406-704    AC A0A068YEE4.1
#=GS A0A1Y2J565_PYCCO/484-782    AC A0A1Y2J565.1
#=GS F8L395_SIMNZ/397-682        AC F8L395.1
#=GS A0A195CD21_9HYME/249-533    AC A0A195CD21.1
#=GS A0A0R3TPA5_RODNA/431-729    AC A0A0R3TPA5.2
#=GS A0A367YPZ9_9ASCO/386-665    AC A0A367YPZ9.1
#=GS G4UNQ9_NEUT9/406-695        AC G4UNQ9.1
#=GS A0A2H3G6I4_FUSOX/396-686    AC A0A2H3G6I4.1
#=GS A0A226ELP8_FOLCA/385-672    AC A0A226ELP8.1
#=GS A0A166N6H4_9EURO/410-699    AC A0A166N6H4.1
#=GS A0A194XHE0_9HELO/401-690    AC A0A194XHE0.1
#=GS A0A059LFX4_9CHLO/8-322      AC A0A059LFX4.1
#=GS W0LA31_9GAMM/401-679        AC W0LA31.1
#=GS A0A446M440_TRITD/398-586    AC A0A446M440.1
#=GS A0A2G5BCJ7_COERN/379-664    AC A0A2G5BCJ7.1
#=GS G1S219_NOMLE/612-893        AC G1S219.2
#=GS A0A5A7PSI8_STRAF/467-785    AC A0A5A7PSI8.1
#=GS A0A2Y9NAW8_DELLE/562-843    AC A0A2Y9NAW8.1
#=GS A0A392MHK9_9FABA/1-160      AC A0A392MHK9.1
#=GS A0A3B0J910_DROGU/501-788    AC A0A3B0J910.1
#=GS B8B7I7_ORYSI/401-680        AC B8B7I7.1
#=GS A0A392M5P9_9FABA/203-244    AC A0A392M5P9.1
#=GS A0A448QWZ8_ACTEU/1-142      AC A0A448QWZ8.1
#=GS A0A665VEZ4_ECHNA/381-662    AC A0A665VEZ4.1
#=GS A0A445LB71_GLYSO/304-584    AC A0A445LB71.1
#=GS A0A662Z1C1_ACIRT/354-635    AC A0A662Z1C1.1
#=GS A0A195CCM9_9HYME/316-602    AC A0A195CCM9.1
#=GS M2LIT2_BAUPA/418-707        AC M2LIT2.1
#=GS S4RDH1_PETMA/303-588        AC S4RDH1.1
#=GS E3LUF3_CAERE/499-717        AC E3LUF3.1
#=GS A0A0B2V2M9_TOXCA/440-724    AC A0A0B2V2M9.1
#=GS A0A5B7YIV2_9ALTE/343-621    AC A0A5B7YIV2.1
#=GS A0A2G5TJN0_9PELO/442-726    AC A0A2G5TJN0.1
#=GS A0A0D1E264_USTMA/485-773    AC A0A0D1E264.1
#=GS T1J428_STRMM/458-740        AC T1J428.1
#=GS A0A1D6N9W4_MAIZE/221-448    AC A0A1D6N9W4.1
#=GS F3LG55_9GAMM/402-684        AC F3LG55.1
#=GS A0A287LRH5_HORVV/375-655    AC A0A287LRH5.1
#=GS A0A195DNI2_9HYME/410-691    AC A0A195DNI2.1
#=GS A0A6A4JW28_APOLU/510-794    AC A0A6A4JW28.1
#=GS A0A397J799_9GLOM/400-682    AC A0A397J799.1
#=GS M1W4R8_CLAP2/407-696        AC M1W4R8.1
#=GS A0A0S3RXS8_PHAAN/377-657    AC A0A0S3RXS8.1
#=GS V4S750_9ROSI/378-657        AC V4S750.1
#=GS A0A5N6V812_9EURO/495-783    AC A0A5N6V812.1
#=GS A0A2G5B8S4_COERN/1-241      AC A0A2G5B8S4.1
#=GS A0A446NRK4_TRITD/377-583    AC A0A446NRK4.1
#=GS A0A2P6QKQ9_ROSCH/447-731    AC A0A2P6QKQ9.1
#=GS A0A395ITD8_9HELO/255-326    AC A0A395ITD8.1
#=GS A0A3P9P0Q3_POERE/546-827    AC A0A3P9P0Q3.1
#=GS A0A1R2AMJ6_9CILI/361-626    AC A0A1R2AMJ6.1
#=GS T1KL19_TETUR/428-705        AC T1KL19.1
#=GS G0R2H5_ICHMG/330-621        AC G0R2H5.1
#=GS K5W849_PHACS/450-742        AC K5W849.1
#=GS M9LQY1_PSEA3/501-789        AC M9LQY1.1
#=GS A0A2T2N0J8_CORCC/411-700    AC A0A2T2N0J8.1
#=GS B7G514_PHATC/403-716        AC B7G514.1
#=GS A0A452RRR7_URSAM/285-551    AC A0A452RRR7.1
#=GS A0A1Y2EN99_9FUNG/377-658    AC A0A1Y2EN99.1
#=GS A0A4Q9XM02_9ALTE/394-669    AC A0A4Q9XM02.1
#=GS A0A3B5KB28_TAKRU/454-735    AC A0A3B5KB28.2
#=GS U6M5F5_EIMMA/312-538        AC U6M5F5.1
#=GS M1CLN2_SOLTU/382-572        AC M1CLN2.1
#=GS O16249_CAEEL/444-658        AC O16249.1
#=GS A0A669ELD7_ORENI/398-679    AC A0A669ELD7.1
#=GS A0A1E5UJ43_9POAL/1-206      AC A0A1E5UJ43.1
#=GS A0A0D2MB40_GOSRA/378-658    AC A0A0D2MB40.1
#=GS A0A2N5Y002_9GAMM/365-644    AC A0A2N5Y002.1
#=GS A0A2K6NKM2_RHIRO/422-703    AC A0A2K6NKM2.1
#=GS A0A078FB24_BRANA/437-589    AC A0A078FB24.1
#=GS A0A6G1DMI6_9ORYZ/312-598    AC A0A6G1DMI6.1
#=GS A0A0V1BTV2_TRISP/1293-1581  AC A0A0V1BTV2.1
#=GS M2RIB5_CERS8/446-744        AC M2RIB5.1
#=GS A0A1U9NGA9_9GAMM/396-679    AC A0A1U9NGA9.1
#=GS A0A1X6ML12_9APHY/430-722    AC A0A1X6ML12.1
#=GS G3R5E6_GORGO/422-703        AC G3R5E6.1
#=GS A0A2J6KRK2_LACSA/446-728    AC A0A2J6KRK2.1
#=GS IDE_HUMAN/422-703           AC P14735.4
#=GS IDE_HUMAN/422-703           DR PDB; 3E4A B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BYZ A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4PES B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2JG4 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4RAL A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4RE9 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4DWK B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3E4Z A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3N57 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2WC0 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6B70 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3E4Z B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6B3Q B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4PF7 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4IFH B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6B70 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5CJO A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BFC B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4DTT B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5WOB H; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6B7Z A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4GS8 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6EDS A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3N56 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4NXO A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4PF7 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3HGZ A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6B7Y A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5UOE E; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BF6 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BF8 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4DTT A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BYZ B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BF6 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3QZ2 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6B7Y B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2WK3 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4NXO B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3H44 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4PF9 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BF7 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2JBU B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BF7 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6B3Q A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2WBY B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BF9 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G56 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G49 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4PES A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4DWK A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G56 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5WOB G; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3CWW B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5WOB F; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4IOF B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3H44 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4RAL B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6EDS B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5WOB C; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BF8 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G49 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BF9 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4QIA A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6BFC A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3HGZ B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5UOE B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4GSC A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5WOB B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4IOF A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G47 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4RE9 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4LTE A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3E4A A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5WOB D; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2JBU A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G48 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2JG4 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G47 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5WOB E; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4QIA B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4IFH A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G54 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5UOE C; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3QZ2 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5UOE D; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3N57 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5WOB A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4GS8 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4PFC A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 5UOE A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4PF9 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2WK3 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3CWW A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3OFI A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3E50 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3N56 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2WBY A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G54 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4LTE B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6MQ3 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2YPU B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4GSF B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4GSC B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4GSF A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3OFI B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4M1C B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4PFC B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2YPU A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6MQ3 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2WC0 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 6B7Z B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 3E50 A; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 2G48 B; 422-703;
#=GS IDE_HUMAN/422-703           DR PDB; 4M1C A; 422-703;
#=GS G3SXF1_LOXAF/391-672        AC G3SXF1.1
#=GS A0A1C3EEI9_9GAMM/343-622    AC A0A1C3EEI9.1
#=GS A0A6I8VZE9_DROPS/391-677    AC A0A6I8VZE9.1
#=GS A0A446S453_TRITD/299-585    AC A0A446S453.1
#=GS A0A3Q2ICM4_HORSE/615-896    AC A0A3Q2ICM4.1
#=GS A0A1U8KWZ1_GOSHI/169-449    AC A0A1U8KWZ1.1
#=GS A8XQA4_CAEBR/306-589        AC A8XQA4.2
#=GS A0A3Q0H3N1_ALLSI/402-683    AC A0A3Q0H3N1.1
#=GS F1P6U4_CANLF/512-675        AC F1P6U4.3
#=GS A0A2K5RTD3_CEBCA/381-662    AC A0A2K5RTD3.1
#=GS A0A5C3LBE4_9AGAR/440-734    AC A0A5C3LBE4.1
#=GS A0A2H5QMK0_CITUN/249-486    AC A0A2H5QMK0.1
#=GS T1MRX1_TRIUA/389-597        AC T1MRX1.1
#=GS A0A060VUJ4_ONCMY/381-662    AC A0A060VUJ4.1
#=GS A0A195AVN4_9HYME/424-700    AC A0A195AVN4.1
#=GS A0A0C3BJB3_9AGAM/391-695    AC A0A0C3BJB3.1
#=GS A0A2P6SBX9_ROSCH/1-95       AC A0A2P6SBX9.1
#=GS A0A3B0K5F3_DROGU/435-722    AC A0A3B0K5F3.1
#=GS IDE_BOVIN/422-703           AC Q24K02.1
#=GS A0A1X1EXL7_PANCY/401-679    AC A0A1X1EXL7.1
#=GS A0A2G5T8C8_9PELO/1-132      AC A0A2G5T8C8.1
#=GS A0A2K1QNQ2_9PEZI/399-688    AC A0A2K1QNQ2.1
#=GS G3UU84_MELGA/1-117          AC G3UU84.1
#=GS A0A1Y0FZC5_9GAMM/408-686    AC A0A1Y0FZC5.1
#=GS A0A5C6PG24_9TELE/381-590    AC A0A5C6PG24.1
#=GS A0A498HZA4_MALDO/534-631    AC A0A498HZA4.1
#=GS A0A2T7NP95_POMCA/399-676    AC A0A2T7NP95.1
#=GS A0A1Y1XZS5_9FUNG/405-544    AC A0A1Y1XZS5.1
#=GS A0A166GJK8_9AGAM/442-739    AC A0A166GJK8.1
#=GS A0A673BM86_9TELE/417-698    AC A0A673BM86.1
#=GS A0A4W3IYV7_CALMI/379-660    AC A0A4W3IYV7.1
#=GS A0A6I8VYS5_DROPS/391-677    AC A0A6I8VYS5.1
#=GS A0A432ZJP6_9GAMM/420-699    AC A0A432ZJP6.1
#=GS A0A1S3CNH0_CUCME/439-725    AC A0A1S3CNH0.1
#=GS A0A452RRX0_URSAM/306-572    AC A0A452RRX0.1
#=GS A0A1X7SKU0_AMPQE/2-96       AC A0A1X7SKU0.1
#=GS A0A182YDY2_ANOST/510-795    AC A0A182YDY2.1
#=GS A0A3P8UG95_CYNSE/484-705    AC A0A3P8UG95.1
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