GenomeNet

Database: Pfam
Entry: Phlebovirus_NSM
LinkDB: Phlebovirus_NSM
Original site: Phlebovirus_NSM 
#=GF ID   Phlebovirus_NSM
#=GF AC   PF07246.12
#=GF DE   Phlebovirus nonstructural protein NS-M
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_17508 (release 10.0)
#=GF GA   27.20 27.20;
#=GF TC   27.80 32.60;
#=GF NC   26.70 27.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR009879;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Phlebovirus nonstructural NS-M
#=GF CC   proteins which represent the N-terminal region of the M
#=GF CC   polyprotein precursor. The function of this family is unknown.
#=GF SQ   21
#=GS A0A1S5SHT8_9VIRU/9-248  AC A0A1S5SHT8.1
#=GS I1T369_9VIRU/1-255      AC I1T369.1
#=GS GP_RVFVZ/89-143         AC P21401.1
#=GS U5XM01_9VIRU/5-224      AC U5XM01.1
#=GS A2T086_RVFV/1-96        AC A2T086.1
#=GS A0A0C5ARY4_9VIRU/1-290  AC A0A0C5ARY4.1
#=GS GP_RVFVZ/1-96           AC P21401.1
#=GS F4ZCL5_9VIRU/2-274      AC F4ZCL5.1
#=GS F2W3Q1_9VIRU/1-278      AC F2W3Q1.1
#=GS I1T324_9VIRU/1-265      AC I1T324.1
#=GS I1ST83_9VIRU/4-260      AC I1ST83.1
#=GS A2T086_RVFV/89-143      AC A2T086.1
#=GS F4ZCK0_9VIRU/3-275      AC F4ZCK0.1
#=GS A0A0S1MT04_PTPV/2-270   AC A0A0S1MT04.1
#=GS A0A1S5SHW2_9VIRU/1-201  AC A0A1S5SHW2.1
#=GS A0A1S5SHU1_9VIRU/3-312  AC A0A1S5SHU1.1
#=GS A0A159D7V5_9VIRU/2-307  AC A0A159D7V5.1
#=GS A0A1S5SHW8_9VIRU/8-291  AC A0A1S5SHW8.1
#=GS I1T341_9VIRU/1-255      AC I1T341.1
#=GS F2W3Q9_9VIRU/1-272      AC F2W3Q9.1
#=GS A0A0U4HUK5_9VIRU/2-291  AC A0A0U4HUK5.1
A0A1S5SHT8_9VIRU/9-248             ............lkafa------VLlTQSVIAEGLFMLKSFKPLS.SAQVCFSSRTPLDGIGVYWIS.EMDK---LVNPTKLCSLG.GSPP.SLMTKTSAFMATRAV.ILSEEPS..ELVCE.S.EDRSEGI.SLSNNGEEE...DLG..PA..IINCR...TR..E.KQ.....EDI..........R..VR...VS..A--..L.........EE.N....D.I----.....---.KRIIEM..TTEYPAT.......................ESPRK..IL..RT..EIRKMET.....SK..EELNDE.....................IA.KlTARH..EAL...VNALRET.MTDRD-..-RE.NNRLLSe........kVEME...NEKREIEH------------------------------kikslnnllesekltvk.....................................................................................................
I1T369_9VIRU/1-255                 .........miylpill--------.-LLRLTAASFVLESTRPKGhSSKVCLSNTSSSKILERYW--.DNLE-QGMPNGPRMCSIG.SGES.HLTSGANIKKLIRDV.RDSPTAL..NVSCVvA.NQPEHSI.SIAFLEIPD..dFIK..PT..SIDCV...TG..E.SI.....REV..........G..TL...DE..A--..-.........--.-....-.-----.....---.------..-------.......................-----..--..--..-------.....--..------.....................--.-.----..---...-------.------..---.------..........----...--------------------------------------asppdfhkpviiemdedtdflpprvlpasndirpvtldtrhghitrdeekialqlevdtlrdqlgverrqiaelnsimqntanmadsereqnqktisekhrqihdqtrqihelereim
GP_RVFVZ/89-143                    ..............itc--------.-------------------.---------------------.------------------.----.---------------.-------..-----.-.-------.---------...---..--..-----...--..-.--.....---..........-..--...--..---..-.........--.-....-.-----.....---.------..HGKDPED.......................-----..--..--..KISLIKG.....PP..HKKRVG.....................IV.R.CERR..RDA...KQIGRKT.MAGIA-..---.------..........----...--------------------------------------mtvlpala..............................................................................................................
U5XM01_9VIRU/5-224                 .......flftalfgia--------.------ACMFKLETESQRY.TNQICFSSSTPVKDMIRYWDS.EIRR---VPGTDYQCRFN.TDPF.ARTTSQGSRELLVSI.TSRTAEN..KYECL.S.QFNDSRI.EFSSDGYSE...EFE..PA..AMMCD...EEkvD.FL.....IQP..........V..VD...QG..APA..V.........DL.EselaK.LKQQA....kDDM.NTLISE..HNKAIQE.......................-----..--..--..-------.....--..------.....................--.-.----..---...-------.------..---.------..........----...--------------------------------------lnnlrsadvrklrevetllrlaekgilsgnttqlrlrqevsslrsqindvnqll................................................................
A2T086_RVFV/1-96                   .................MYVLLTIL.-ISVLVCEAV-IRVSLSST.REETCFGDSTNPEMIEGAW--.DSLREEEMPE-ELSCS--.----.--------ISGIREV.KTSSQEL..Y----.-.--RALKA.IIAADGLNN...IT-..--..-----...--..-.--.....---..........-..--...--..---..-.........--.-....-.-----.....---.------..-------.......................-----..--..--..-------.....--..------.....................--.-.----..---...-------.------..---.------..........----...--------------------------------------chgkdp................................................................................................................
A0A0C5ARY4_9VIRU/1-290             .............myql---IVLIL.QRIVLAESKVSLTITSPDY.SSLSCFNSAVSAKFVQRKWAT.EVSK---MGDFDQFCYYN.NDIP.KRSTGENSQGIMTFV.VLSDVPY..TFSCV.S.EDRSKLA.IVHNDGVPS...DGE..PA..YIDCE...KG..S.MIhllssSDP..........D..VP...KS..NPA..Le.......eEH.E....L.LKERF.....DDL.QLKFND..NVRRLEA.......................--ENQ..DL..KV..RLDQLHSsreslKL..QKSEQEgnlt............qlnaiIHdL.TKKV..RDG...ENAVLNL.LSEARR..DKE.ALIQLEedt...drrlEEND...RLIASLKARAHNIIRAPTTVKPLITTAI----------avtllssallv...........................................................................................................
GP_RVFVZ/1-96                      .................MYVLLTIL.-TSVLVCEAI-IRVSLSST.REETCFGDSTNPEMIEGAW--.DSLREEEMPE-ELSCS--.----.--------ISGIREV.KTSSQEL..Y----.-.--RALKA.IIAADGLNN...IT-..--..-----...--..-.--.....---..........-..--...--..---..-.........--.-....-.-----.....---.------..-------.......................-----..--..--..-------.....--..------.....................--.-.----..---...-------.------..---.------..........----...--------------------------------------chgkdp................................................................................................................
F4ZCL5_9VIRU/2-274                 .......kiiqyfcyis--------.----FVVSRLVLHYSTPTY.SNKICFSSGSPEPIVTDYW--.-MEVMESFPPGHQKCELG.DGQF.SAVVLDDMPKFIKAM.TTSDQAL..RLTCI.G.QNDSYIS.ELTTDGD-V...IPG..EFhsEVDCK...NG..A.II.....KEL..........S.rVN...VA..PAG..V.........HA.R....D.LLLES.....AET.DAILKQ..RDQLIAElrek...............lrdsKVRED..AA..MQ..RNKVNTE.....LLseTKDRAD.....................--.K.LQRR..ADE...LILHLES.E-RVEGkiSRN.RSKWLE..........HELK...DAKEDISRLRLDIGRTTTRK------------------pkglisltttmipllllmtse.................................................................................................
F2W3Q1_9VIRU/1-278                 ...............mk---ILHLL.TNIMYALGAYIITGWSMEG.TTRVCLSNESPLEGIVYYWET.ERKRRGMESSSNLDCRVG.EGEL.KRISNKTLIRLIEEV.QLSTYEL..KVSCE.K.SSNDTGL.SIDFNGLDD..tEPG..HH..IVDCE...KM..R.YV.....SDL..........G..VT...VG..DGL..Aw......dsRYnE....S.YKQELl..rkDE-.------..KLREFENelshlkltg....iddkneimslIRENQ..ML..QH..RISNLTG.....SN..ENKNNS.....................--.-.----..--L...RILKNEL.MQAESH..RDNlEREILN..........HKDR...HAKLEGDFIKLKSSMF-SVQVVTTVLPLLSLVGTSL--aatpim................................................................................................................
I1T324_9VIRU/1-265                 .............myie---IVSVM.LLASTVYCAYILTASRPKG.TTKICLSNLTPYNSLTSYW--.NNLN-SDLENGDRQCSVG.TSGM.SYTTNSTIMSLIREV.QISQAHI..TLTCK.PlEAEDEKI.SMRFDGLAD..dFHY..PS..VLNCE...--..-.-N.....SSL..........S..LG...PI..PNI..V........pDM.G....DlIREDA.....NDK.IGFLRD..RLASMEEr.....................lVSETK..LLeaER..EIRNQEL.....ND..HSERYHf...................nDV.R.LKAH..E--...-DDIKDK.DDKISE..QKH.IIAMLS..........KNIT...ILHDKLNKMSINPRAEMKVIPTVVSVALLSSSLTSA--al....................................................................................................................
I1ST83_9VIRU/4-260                 ..............yqi--IYLIVL.TS--GVSSLVRLSSRKSSY.LGKICFSAETPAEGVMVYWLS.EVSK---MSPGAMDCSKA.GGDY.RKMDRKEMSSYMTDVvESAASGLddSFSCL.G.NNEGIEI.VSDQIRTED...--R..PM..VVNCD...TG..N.FQ.....EEV..........R..VI...GI..AGRppVr......mpEK.T....P.VMEDP....vEEN.GAASRL..SEIQKEVell................rldqANKQK..QL..NE..AIEKMKK.....LK..ESHGLE.....................V-.-.DKRE..DEL...DRLIGEK.KRLEGD..LNK.ERSLSTr.......leNELS...ILKNEIFRREN---------------------------narkieeea.............................................................................................................
A2T086_RVFV/89-143                 ..............itc--------.-------------------.---------------------.------------------.----.---------------.-------..-----.-.-------.---------...---..--..-----...--..-.--.....---..........-..--...--..---..-.........--.-....-.-----.....---.------..HGKDPED.......................-----..--..--..KISLIKG.....PP..HKKRVG.....................IV.R.CERR..RDA...KQIGRET.MAGIA-..---.------..........----...--------------------------------------mtvlpala..............................................................................................................
F4ZCK0_9VIRU/3-275                 ..............nyn------IL.FLLSIVAARLVLHYSTPHL.NNKICFSSGTPELHITNYWME.AMEK---FPVDNKKCELG.DGVF.SSVTLDDMPPFIKAM.TTSDEAL..RFTCI.G.SNDSYIA.ELTTDGDV-...IPGesHS..IIDCK...TG..E.TEv..vlSPV..........N..VA...PA..GLK..Vqd.....lvDH.D....R.EVDAV....lLQR.DQLIEE.lRTRLRDS.......................KIREE..SA..KE..KSKQLTE.....EL..DTMKKD.....................ID.K.FKGR..TDElilHLESERL.ESRIS-..-RN.KSRWLE..........HELK...DAKEDVIRLQN---------------------------dmlrepkkkssserttkaslktvllytttmi.......................................................................................
A0A0S1MT04_PTPV/2-270              .................IFTILNVL.TRAMLVMSMYSLTTWDSTS.RNDMCFSNDSPLEGLVYYWET.HSKKHDYKKQESQRCRVG.DSDK.KMITNVTIISLISEI.QKSISEL..SLSCG.N.DDNSTGQ.VLTFNGLED..tIRG..DY..IVDCV...TG..L.YQ.....SDI..........G..VG...VG..LGR..Th.......hGH.Q....Q.MKNKAv..viDEK.ERMISL.lETQQSEN.......................DIKMQ..VL..MS..EIEQLKN.....QL..SKKRNE.....................--.R.GQEK..RDA...EKVMSDL.MARNSD..LRK.HNDILT..........AEIS...QMKNKNTIQRNKNTVSTTVVPAILSVALLSSSVAPIIA......................................................................................................................
A0A1S5SHW2_9VIRU/1-201             ..............mky----FIVL.TILGLVDATFKLATMTPNR.KQEVCIDSGATLNQMQSIW--.DDLN-NSLATGTRSCTLE.EGTF.SFVNERDYKTLLQAV.FSSDVPL..KLDCV.L.KDD-YKQ.QISFETDGDlipKEH..PS..IVNCK...TR..A.YI.....SDI..........R..PR...VE..HPE..E.........RT.E....K.VAASG.....HSK.RGMTDD..E-RALEE.......................ELRAL..LT..KK..EIYIMNL.....QE..EKNK--.....................--.-.----..---...-------.------..---.------..........----...--------------------------------------wrllgeyedvkeklts......................................................................................................
A0A1S5SHU1_9VIRU/3-312             .............yfki-----IILtSLAGLSESLIKVGSIHSGG.SSKVCLSNRTPAETVLSYWES.QFSQ---LPQGQYLCQVG.SERK.EEMDSRKIRRLVKEV.GESITAI..FFQCQyK.ENEGYGI.NVMFDGIDN..tGEG..TY..IADCD...DG..RkKI.....SDVrltplisrsqG..TGddeVT..EPD..I.........SR.N....R.VRGDLr..alQEKvNRMHAE..HAKQTLEnev.................lkeEMRKEglLS..SS..RIQQLQE.....RL..DEAIDDie................drkLE.R.DKAI..EDH...KRTLNEAvQLRIE-..-IN.HLHKLI..........EVEG...NLKKEM--------------------------------qreleekhkqminlknaisassqgkglgsfvtmaipiittisllgsasa.....................................................................
A0A159D7V5_9VIRU/2-307             ............ieifl--IVLVVA.SAMLLALADVRLDSISSGK.EESICFSQNTKVLWIESYWGY.EMAK---MPGFDLYCRYNdDGDY.KFMTNEKARQQIPLV.SGAPDSM..RFSCG.D.KNGEFSV.TLTNDGRNN...MME..GA..LIKCG...TK..E.FI.....KSL..........P..DS...VS..VPT..TeasvsivngTW.E....K.ELEKA.....ENA.RKQGAR..---LHEEvk..................aslEGKLS..AL..KH..ELEKKEN.....DL..ERTKSEl..................esVRmS.IGRK..MEA...EDKLQDA.QYIIEQ..LRE.KVASLTsrvansetdrEDLL...RAKNEMKELRRQVKSME---------------------detneirrafmqrpettksppliattmlallstatia.................................................................................
A0A1S5SHW8_9VIRU/8-291             ffvsfalssyiltnlrp--------.-----------------GG.SSKVCLSNTTSDKTLIEYWERlESPS-GEHINRTRSCRLG.DAPY.SFSTSRNIRNLIKEV.QKSPSEM..TLECN.M.NEEGTETiSLRFDALSGs.dHIQ..PS..SIDCD...TG..E.VI.....APV..........R..ST...YRavEKK..I........pDQ.D....S.STPAAavmtvPAV.DLEYER..KIK----.......................DLEVQ..LA..NV..KIELLSE.....RE..QVESIKanlqnqvglsdnairsaddiiRK.K.NEEI..RSL...QLSTRNL.DHEINK..LKN.SHGRLE..........EDLReerRAKHEMNRSLQ-ASFMTTVIPVVTTIALLSDV------alaa..................................................................................................................
I1T341_9VIRU/1-255                 ...........mfvgif-----ILLvTIVTESESLYKIQTSSERG.KTEICLSNDVPTETLAYYWGL.SVDE-----SLRLDCSIGsPDNY.KATSTKEIKNMIRLV.QDSVSKL..KFSCK.N.DDMGFTS.SMAFDGLAN..tDSG..TL..IVSCKdgsTS..G.FV.....RVI..........G..AP...EN..KAV..It......alES.D....K.RDEGA.....---.AERISE..LMQQIDSlrgelkn........tlsnqdglRESEQ..RA..VK..ELEDLKE.....EL..KMKENL.....................--.K.SEDL..AEY...TKKIESQ.EALISK..LER.EIS---..........-DLK...KVRGDLRALSQKHKD-----------------------slq...................................................................................................................
F2W3Q9_9VIRU/1-272                 ...............mk---ILAFF.ANIMVAYAAYSISNWGLDG.SETVCLSNESPLEGLVHYWEN.GIKK-RKMDRKIKNCKIG.SEPL.KTMDNRTVMSIIEQV.QLSITNL..RLTCA.S.ESGLEGV.YVDFNGLDD..tEAG..RN..IVDCE...NF..K.II.....SEL..........GidIG...DG..YSW..V........aQY.N....GsYAKEI.....REK.DEIIKKlrEGQENADilmrdd..........kneilslIRENQ..ML..QH..RISNLTG.....VV..YNFNNSlral.............endlAL.R.EQEH..RKV...RAE----.------..---.------..........----...--------------------------------------aeknhvrkgsqekgshsdfiklksvltsalvattvlpmvtass...........................................................................
A0A0U4HUK5_9VIRU/2-291             ...........ivttfl------FL.QCLVLVELRVSLTISSPEY.SSQNCFNSAVDPKFLQRKWAT.EASK---MGDFDYQCSYD.-TDTpVSSTKENAQGLLTFT.VLSQYPS..QFSCV.D.ETRKMRI.SIQNNGEKE...DGE..AA..YLDCE...KN..T.LI.....HLI..........S..TA...EP..FPD..Hklda.elaqEH.E....N.LKRRF.....---.---KDL..QTKFSSDrerlteenerlkselsslhttreLLKDQ..KA..MQdrNLTMLNA.....VI..HNLNKR.....................VK.E.GESAlsEAL...NQARRDK.EALIFL..EED.TDKKLE..........NNES...IIKSLQEELRKVSLPRIPLLPAVTTIATISLLSSSLV-v.....................................................................................................................
#=GC seq_cons                      ..............hhh......lh....hhs.uhh.lps.pspt.psclChSssos.chl.tYW...c.tc...hsshshpCphs.ss.h.phhsppshhphlptV.ptSsptl..phsCh.s.pspshth.plshsGhss.....t..s...hlsCc...pt..t.h......ppl..........s..ss....t...s...h.........ph.p....p.hhtth......t..t..hp...php..pp.........................c.p...h...p..clp.hpt.........pptp.p........................p..pth..tth...p..htph.....t.....p..........................h...................................stt...................................................................................................................
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